Details of the Drug

General Information of Drug (ID: DM25K86)

• Drug Name: 3-Benzoyl-N-hydroxy-benzamide
• Synonyms: CHEMBL175908; 3-Benzoyl-N-hydroxy-benzamide; 3-Benzoylbenzohydroximic acid; SCHEMBL14880296; ZINC28108876

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 241.24
  Logarithm of the Partition Coefficient (xlogp); 1.6
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C14H11NO3
  IUPAC Name: 3-benzoyl-N-hydroxybenzamide
  Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=CC(=CC=C2)C(=O)NO
  InChI: InChI=1S/C14H11NO3/c16-13(10-5-2-1-3-6-10)11-7-4-8-12(9-11)14(17)15-18/h1-9,18H,(H,15,17)
  InChIKey: LAZDNRBVPKMJSY-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 44386957
  TTD ID: D05RIE

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

References

• [1] Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. J Med Chem. 1990 Mar;33(3):992-8.