Details of the Drug

General Information of Drug (ID: DM2POGY)

Drug Name

AMG 509

Indication

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Phase 1	[1]
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Drug Type

Antibody

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metalloreductase STEAP1 (STEAP1)	TT9E64S	STEA1_HUMAN	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

ICD Disease Classification

02 Neoplasm

Disease Class

ICD-11: 2C82 Prostate cancer

The Studied Tissue

Prostate

The Studied Disease

Prostate cancer [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Metalloreductase STEAP1 (STEAP1)	DTT	STEAP1	1.46E-02	0.78	1.22

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT04221542) Study of AMG 509 in Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Amgen.