Details of the Drug

General Information of Drug (ID: DM2UP6Z)

Drug Name

ARO-AAT

Indication

Disease Entry	ICD 11	Status	REF
Alopecia	ED70	Phase 2	[1]
Alpha-1 antitrypsin deficiency	5C5A	Phase 1	[2]
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Drug Type

Small interfering RNA

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SERPINA1 messenger RNA (SERPINA1 mRNA)	TT2L4TV	A1AT_HUMAN	Not Available	[3]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT03946449) Study of ARO-AAT in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD). U.S. National Institutes of Health.
2	ClinicalTrials.gov (NCT03362242) Study of ARO-AAT in Normal Adult Volunteers. U.S. National Institutes of Health.
3	Clinical pipeline report, company report or official report of Arrowhead Pharmaceuticals.