Details of the Drug

General Information of Drug (ID: DM3I5NU)

Drug Name

TPI 287

Synonyms

FDTAUJJRHBRHIJ-BBGIBMRQSA-N; 849213-15-6; SCHEMBL19374618; Hexanoic acid, 3-(((1,1-dimethylethoxy)carbonyl)amino)-2-hydroxy-5-methyl-, (1S,2S,4S,7S,7aR,10aS,11aR,13aS,13bR,13cS)-7,13a-bis(acetyloxy)-1-(benzoyloxy)-9-ethenyl-1,3,4,7,7a,10a,11,11a,13,13a,13b,13c-dodecahydro-2-hydroxy-5,13c,14,14-tetramethyl-2,6-methano-2H-cyclodec(de)oxeto(3,2-g)(1,3)benzodioxin-4-yl ester, (2R,3S)-

Indication

Disease Entry	ICD 11	Status	REF
Glioma	2A00.0	Phase 2	[1]
Recurrent glioblastoma	2A00.00	Phase 2	[2]
Alzheimer disease	8A20	Phase 1	[3]
Brain metastases	2D50	Phase 1	[2]
Progressive supranuclear palsy	8A00.10	Phase 1	[1]
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Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C46H63NO15
Canonical SMILES: CC1=C2C(C3C4(C(CC5C(C4C(C(C2(C)C)(CC1OC(=O)C(C(CC(C)C)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO5)OC(=O)C)OC(O3)C=C)C)OC(=O)C
InChI: 1S/C46H63NO15/c1-13-32-58-30-20-31-45(22-55-31,61-26(6)49)36-38(60-39(51)27-17-15-14-16-18-27)46(54)21-29(57-40(52)34(50)28(19-23(2)3)47-41(53)62-42(7,8)9)24(4)33(43(46,10)11)35(56-25(5)48)37(59-32)44(30,36)12/h13-18,23,28-32,34-38,50,54H,1,19-22H2,2-12H3,(H,47,53)/t28-,29-,30-,31+,32?,34+,35-,36-,37-,38-,44+,45-,46?/m0/s1
InChIKey: FDTAUJJRHBRHIJ-BBGIBMRQSA-N

Cross-matching ID

PubChem CID: 118797983
CAS Number: 849213-15-6
TTD ID: D07IOT

Repurposed Drugs (RPD)

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)