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Clinical pipeline report, company report or official report of Octapharma.
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FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761269.
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4253).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7746).
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ClinicalTrials.gov (NCT02371369) PLX3397 Phase 3 Study for Pigmented Villonodular Synovitis (PVNS) or Giant Cell Tumor of the Tendon Sheath (GCT-TS). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00950430) Imaging of Brain Amyloid Plaques in the Aging Population. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03116126) Randomised Clinical Trial of Noradrenergic Add-on Therapy With Extended-Release Guanfacine in Alzheimer's Disease. U.S.National Institutes of Health.
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Neurotrophic and neuroprotective actions of (-)- and (+)-phenserine, candidate drugs for Alzheimer's disease. PLoS One. 2013;8(1):e54887.
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ClinicalTrials.gov (NCT05531526) A Phase 3 Double-blind, Randomized, Placebo-controlled, Multi-center Trial to Evaluate the Efficacy and Safety of AR1001 Over 52 Weeks in Participants With Early Alzheimer's Disease (Polaris-AD). U.S.National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031727)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027191)
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6930).
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ClinicalTrials.gov (NCT04229927) A Multicenter, Randomized, Double-blind, Active-controlled, Phase III Clinical Trial to Evaluate the Efficacy and Safety of BPDO-1603 in Patients With Moderate-to-severe Alzheimer's Disease. U.S.National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014948)
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ClinicalTrials.gov (NCT05108922) A Phase 3, Open-Label, Parallel-Group, 2-Arm Study to Investigate Amyloid Plaque Clearance With Donanemab Compared With Aducanumab-avwa in Participants With Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT02004392) Study of the Safety and Clinical Effects of 2 Doses of EVP-6124 in Subjects With Alzheimer's Disease Who Complete Study EVP-6124-024 or EVP-6124-025. U.S. National Institutes of Health.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6933).
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ClinicalTrials.gov (NCT01245530) An Efficacy and Safety Study of INM-176 for the Treatment of Patients With Alzheimer Type Dementia. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00528112) Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034429)
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ClinicalTrials.gov (NCT01960010) A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye. U.S. National Institutes of Health.
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40 |
ClinicalTrials.gov (NCT04669028) A Phase 3, Double Blind, Randomized, Placebo Controlled, Parallel Group, Multicenter Study of NE3107 in Subjects Who Have Mild to Moderate Probable Alzheimer's Disease. U.S.National Institutes of Health.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8325).
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42 |
ClinicalTrials.gov (NCT05463731) Assessment of Safety, Tolerability, and Efficacy Measured by Amyloid Reduction of LY3372993 in Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Clinical pipeline report, company report or official report of SEIKAGAKU.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6932).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
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47 |
ClinicalTrials.gov (NCT00262821) Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer. U.S. National Institutes of Health.
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48 |
ClinicalTrials.gov (NCT00314912) Open-Label Extension of the Phase III Study With Tramiprosate (3APS) in Patients With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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49 |
ClinicalTrials.gov (NCT01689246) Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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50 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601)
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ClinicalTrials.gov (NCT03823404) GAIN Trial: A Randomized, Double-Blind, Placebo-Controlled Study of COR388 in Subjects With Alzheimer's Disease. U.S.National Institutes of Health.
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52 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7789).
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53 |
ClinicalTrials.gov (NCT02565511) A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease.
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54 |
ClinicalTrials.gov (NCT02565511) A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease (Generation S1). U.S. National Institutes of Health.
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55 |
ClinicalTrials.gov (NCT05269394) A Phase II/III Multicenter Randomized, Double-Blind, Placebo-Controlled Platform Trial of Potential Disease Modifying Therapies Utilizing Biomarker, Cognitive, and Clinical Endpoints in Dominantly Inherited Alzheimer's Disease. U.S.National Institutes of Health.
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56 |
ClinicalTrials.gov (NCT04886063) Open-Label Extension of Studies ATH-1017-AD-0201 and ATH-1017-AD-0202 in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
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57 |
ClinicalTrials.gov (NCT03090516) Clinical Study on Improving the Cognitive Function of Patients With Mild to Moderate Alzheimer's Disease by Using Ginkgo Biloba Dispersible Tablets. U.S.National Institutes of Health.
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58 |
ClinicalTrials.gov (NCT02719327) Impact of Icosapent Ethyl on Alzheimers Disease Biomarkers in Preclinical Adults. U.S.National Institutes of Health.
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59 |
ClinicalTrials.gov (NCT02569398) An Efficacy and Safety Study of JNJ-54861911 in Participants Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia.
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60 |
ClinicalTrials.gov (NCT01554956) Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients. U.S. National Institutes of Health.
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61 |
ClinicalTrials.gov (NCT02205840) A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.. U.S. National Institutes of Health.
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62 |
ClinicalTrials.gov (NCT02579252) 24 Months Safety and Efficacy Study of AADvac1 in Patients With Mild Alzheimer's Disease (ADAMANT). U.S. National Institutes of Health.
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63 |
ClinicalTrials.gov (NCT03712787) An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD). U.S. National Institutes of Health.
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64 |
ClinicalTrials.gov (NCT05291234) A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of ABBV-916 in Subjects With Early Alzheimer's Disease. U.S.National Institutes of Health.
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65 |
ClinicalTrials.gov (NCT01655680) A Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia. U.S. National Institutes of Health.
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66 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6927).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7357).
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68 |
ClinicalTrials.gov (NCT03461276) A Multi-center, Randomized, Double-blind, Placebo-controlled, 24 Months Study in Patients With Amnestic Mild Cognitive Impairment or Very Mild Alzheimer's Disease to Investigate the Safety, Tolerability and Immune Response of Repeated Subcutaneous Injections of ABvac40. U.S.National Institutes of Health.
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69 |
ClinicalTrials.gov (NCT03790982) A Randomized, Double Blind, Placebo Controlled, Parallel-Group 52-week Multicenter Phase II Study to Investigate the Safety, Efficacy and Pharmacokinetics of AD-35 Tablet in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
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70 |
Clinical pipeline report, company report or official report of Affiris.
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71 |
ClinicalTrials.gov (NCT04592874) A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease. U.S.National Institutes of Health.
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72 |
ClinicalTrials.gov (NCT00021723) Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease. U.S. National Institutes of Health.
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73 |
ClinicalTrials.gov (NCT03806478) Safety, Tolerability and Efficacy Assessment of Intranasal Nanoparticles of APH-1105, A Novel Alpha Secretase Modulator For Mild to Moderate Cognitive Impairment Due to Alzheimer's Disease(AD). U.S.National Institutes of Health.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7371).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030006)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031585)
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77 |
ClinicalTrials.gov (NCT01012375) Study to Investigate the Efficacy and Tolerability of AZD1446 in Adult ADHD Patients.. U.S. National Institutes of Health.
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78 |
ClinicalTrials.gov (NCT01548287) A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment. U.S. National Institutes of Health.
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79 |
ClinicalTrials.gov (NCT00991419) To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden. U.S. National Institutes of Health.
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80 |
ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
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81 |
ClinicalTrials.gov (NCT02292238) Benfotiamine in Alzheimer's Disease: A Pilot Study. U.S.National Institutes of Health.
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82 |
ClinicalTrials.gov (NCT04867616) A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer's Disease (AD), Followed by an Open-Label Extension Period. U.S.National Institutes of Health.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6489).
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84 |
ClinicalTrials.gov (NCT03817684) Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects. U.S. National Institutes of Health.
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85 |
ClinicalTrials.gov (NCT03560245) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Assessing the Safety, Tolerability and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease Subjects Not Receiving Memantine Treatment. U.S.National Institutes of Health.
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86 |
ClinicalTrials.gov (NCT00876863) Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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87 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7339).
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88 |
ClinicalTrials.gov (NCT00621270) Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant Anxiety. U.S. National Institutes of Health.
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89 |
ClinicalTrials.gov (NCT02185053) A Phase II Study of CPC-201 to Treat Alzheimer's Disease Type Dementia. U.S. National Institutes of Health.
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90 |
ClinicalTrials.gov (NCT04735536) Pilot Clinical Study of CT1812 in Mild to Moderate Alzheimer's Disease Using EEG. U.S. National Institutes of Health.
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91 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842).
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92 |
ClinicalTrials.gov (NCT04798989) A Phase 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CY6463 When Administered to Participants With Alzheimer's Disease and Vascular Pathology. U.S.National Institutes of Health.
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93 |
ClinicalTrials.gov (NCT00154635) Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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94 |
ClinicalTrials.gov (NCT03055741) A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase IIb, Clinical Study to Evaluate the Safety and Efficacy of DHP1401 in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil(DRAMA). U.S.National Institutes of Health.
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95 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030024)
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96 |
ClinicalTrials.gov (NCT01661673) Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease. U.S. National Institutes of Health.
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97 |
ClinicalTrials.gov (NCT00087724) A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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98 |
Clinical pipeline report, company report or official report of Forum pharmaceuticals.
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99 |
ClinicalTrials.gov (NCT01221246) Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours. U.S. National Institutes of Health.
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100 |
ClinicalTrials.gov (NCT01772199) Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
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101 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027328)
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102 |
ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health.
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103 |
Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
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104 |
ClinicalTrials.gov (NCT03363269) A Multi-center, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Evaluate the Efficacy and Safety of ID1201 for Dose-finding in Mild Alzheimer's Disease. U.S.National Institutes of Health.
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105 |
Inhibition of I B phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45.
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106 |
ClinicalTrials.gov (NCT04619420) A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease. U.S.National Institutes of Health.
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Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6475).
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109 |
ClinicalTrials.gov (NCT03367403) A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ). U.S. National Institutes of Health.
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110 |
ClinicalTrials.gov (NCT05063539) Assessment of Safety, Tolerability, and Efficacy of LY3372689 in Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
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111 |
Amarantus BioScience Licenses LymPro Alzheimer's Disease Diagnostic Blood Test
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112 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033430)
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113 |
ClinicalTrials.gov (NCT00843518) Treatment for Aggression and Agitation in Patients With Alzheimer's Disease. U.S. National Institutes of Health.
|
114 |
Clinical pipeline report, company report or official report of Meta-IQ Aps.
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115 |
Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52.
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116 |
ClinicalTrials.gov (NCT05602727) A Phase 2a/2b Randomized, Placebo-Controlled Clinical Study To Evaluate The Safety And Efficacy Of MK-1942 As Adjunctive Therapy In Participants With Mild To Moderate Alzheimer's Disease Dementia. U.S.National Institutes of Health.
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117 |
ClinicalTrials.gov (NCT01852110) Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012). U.S. National Institutes of Health.
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118 |
ClinicalTrials.gov (NCT03038035) The Alzheimer's Disease THErapy With NEuroaid (ATHENE) Study : Assessing the Safety and Efficacy of Neuroaid II (MLC901) in Patients With Mild to Moderate Alzheimer's Disease Stable on Cholinesterase Inhibitors or Memantine: A Randomized, Double Blind, Placebo Controlled Trial. U.S.National Institutes of Health.
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119 |
ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health.
|
120 |
ClinicalTrials.gov (NCT05194163) A Phase 2a Study of MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
|
121 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006456)
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122 |
ClinicalTrials.gov (NCT00001933) Nefiracetam in the Treatment of Alzheimer's Disease. U.S. National Institutes of Health.
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123 |
ClinicalTrials.gov (NCT01928420) A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
|
124 |
Clinical pipeline report, company report or official report of Neuraly
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125 |
ClinicalTrials.gov (NCT02035553) A Study of the Safety and Efficacy of Pimavanserin in Patients With Alzheimer's Disease Psychosis. U.S. National Institutes of Health.
|
126 |
ClinicalTrials.gov (NCT02471196) Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease.
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127 |
ClinicalTrials.gov (NCT03867253) A Multicentre,Randomised, Double-blind, Placebo-controlled, 3-arm, 24-week Parallel-group Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ORY-2001 in Patients With Mild-moderate Alzheimer's Disease. U.S.National Institutes of Health.
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128 |
ClinicalTrials.gov (NCT01590888) Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease. U.S. National Institutes of Health.
|
129 |
ClinicalTrials.gov (NCT01712074) Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil. U.S. National Institutes of Health.
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130 |
ClinicalTrials.gov (NCT00930059) A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease. U.S. National Institutes of Health.
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131 |
ClinicalTrials.gov (NCT01821118) Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy. U.S. National Institutes of Health.
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132 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021864)
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133 |
ClinicalTrials.gov (NCT04388254) Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients (PTI-125). U.S. National Institutes of Health.
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134 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021506)
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135 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026046)
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136 |
ClinicalTrials.gov (NCT03289143) A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease. U.S. National Institutes of Health.
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137 |
ClinicalTrials.gov (NCT03462121) A 6-Month, Double-Blind, Phase 2 Study and 6-Month Open- Label Extension Evaluating the Safety, Tolerability, and Clinical Benefit of RPh201 in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease. U.S.National Institutes of Health.
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138 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032202)
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139 |
ClinicalTrials.gov (NCT04602624) An Open-Label Evaluation of the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT00621010) Safety Study of CTS21166 to Treat Alzheimer Disease. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT01560884) Study to Assess the Safety and the Phosphate Binding Capacity of Renazorb. U.S. National Institutes of Health.
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281 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024230)
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282 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009546)
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283 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028783)
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284 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030748)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012921)
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286 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028311)
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287 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033289)
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288 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017461)
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289 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024936)
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290 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025887)
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2011 Pipeline of Anavex.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013391)
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ClinicalTrials.gov (NCT03431844) Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac Operation. U.S. National Institutes of Health.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021196)
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Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
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Clinical trials with pegylated liposomal Doxorubicin in the treatment of ovarian cancer. J Drug Deliv. 2013;2013:898146.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007119)
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In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40.
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Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology. Life Sci. 1993;52(5-6):497-503.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003560)
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PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106.
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Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019997)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004498)
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315 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
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316 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006757)
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317 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001957)
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004819)
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4210).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003218)
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322 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692)
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323 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006922)
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324 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007171)
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Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of rhesus monkey. Neurochem Int. 1990;17(2):325-9.
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Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52.
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329 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005356)
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330 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005353)
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331 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017252)
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A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000634)
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334 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007561)
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335 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001729)
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336 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029796)
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337 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 350).
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Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004137)
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339 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000565)
|
340 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005755)
|
341 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000552)
|
342 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4347).
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The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7337).
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Novel -secretase enzyme modulators directly target presenilin protein. J Biol Chem. 2011 Oct 28;286(43):37181-6
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5015).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).
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URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
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Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.ACS Omega. 2019 Oct 2;4(16):16943-16955. doi: 10.1021/acsomega.9b02307. eCollection 2019 Oct 15.
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Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease.Neurobiol Dis. 2020 Feb;134:104644. doi: 10.1016/j.nbd.2019.104644. Epub 2019 Oct 24.
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Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.Clin Epigenetics. 2019 Mar 21;11(1):52. doi: 10.1186/s13148-019-0636-y.
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Serum Adiponectin is Related to Dementia.J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):779-783. doi: 10.1093/gerona/glz102.
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Significant enhanced expressions of aquaporin-1, -4 and -9 in the brains of various prion diseases.Prion. 2019 Jan;13(1):173-184. doi: 10.1080/19336896.2019.1660487.
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Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.Neurobiol Dis. 2019 May;125:176-189. doi: 10.1016/j.nbd.2019.02.003. Epub 2019 Feb 6.
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C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta.ASN Neuro. 2017 Feb;9(1):1759091416687871. doi: 10.1177/1759091416687871.
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Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.Front Pharmacol. 2019 Oct 28;10:1282. doi: 10.3389/fphar.2019.01282. eCollection 2019.
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Alteration in memory cognition due to activation of caveolin-1 and oxidative damage in a model of dementia of Alzheimer's type.Indian J Pharmacol. 2019 May-Jun;51(3):173-180. doi: 10.4103/ijp.IJP_81_17.
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Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline.Neurobiol Aging. 2019 Apr;76:125-132. doi: 10.1016/j.neurobiolaging.2018.12.019. Epub 2019 Jan 7.
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Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies.J Neurol Neurosurg Psychiatry. 2019 May;90(5):590-598. doi: 10.1136/jnnp-2018-319148. Epub 2019 Jan 10.
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Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.Curr Drug Targets. 2017;18(10):1179-1190. doi: 10.2174/1389450116666151001111826.
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Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice.PLoS One. 2017 Jul 27;12(7):e0181367. doi: 10.1371/journal.pone.0181367. eCollection 2017.
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Phosphorylated NF-B subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy.Neurosci Lett. 2019 Jun 21;704:229-235. doi: 10.1016/j.neulet.2019.03.036. Epub 2019 Apr 1.
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Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.J Neurosci. 2020 Jan 29;40(5):1133-1144. doi: 10.1523/JNEUROSCI.1333-19.2019. Epub 2019 Dec 10.
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Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer's Disease.Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):302-307. doi: 10.1177/1533317519848237. Epub 2019 May 7.
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Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene. JCI Insight. 2020 Feb 27;5(4):e135119. doi: 10.1172/jci.insight.135119.
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The effect of early growth response 1 on levels of Amyloid- 40 peptide in U87MG cells.J Cell Biochem. 2019 Mar;120(3):3514-3519. doi: 10.1002/jcb.27627. Epub 2018 Dec 12.
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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.
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Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5.Peptides. 2019 Aug;118:170102. doi: 10.1016/j.peptides.2019.170102. Epub 2019 Jun 11.
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VEGF receptor-1 modulates amyloid 1-42 oligomer-induced senescence in brain endothelial cells.FASEB J. 2019 Mar;33(3):4626-4637. doi: 10.1096/fj.201802003R. Epub 2018 Dec 21.
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Neurofilament Proteins as Prognostic Biomarkers in Neurological Disorders.Curr Pharm Des. 2020;25(43):4560-4569. doi: 10.2174/1381612825666191210154535.
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Fighting the Cause of Alzheimer's and GNE Myopathy.Front Neurosci. 2018 Oct 15;12:669. doi: 10.3389/fnins.2018.00669. eCollection 2018.
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Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer's Disease.Curr Alzheimer Res. 2019;16(10):871-894. doi: 10.2174/1570159X17666190409144558.
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Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer's Disease Treated with the Acetyl Amyloid- Peptide, A(25-35).Med Sci Monit. 2018 May 1;24:2693-2699. doi: 10.12659/MSM.906933.
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Structure, regulation and related diseases of the actin-binding protein gelsolin.Expert Rev Mol Med. 2019 Jan 30;20:e7. doi: 10.1017/erm.2018.7.
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Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.Nat Genet. 2019 Mar;51(3):404-413. doi: 10.1038/s41588-018-0311-9. Epub 2019 Jan 7.
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HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.J Steroid Biochem Mol Biol. 2018 Sep;182:21-26. doi: 10.1016/j.jsbmb.2018.04.007. Epub 2018 Apr 17.
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Risk of Late-Onset Alzheimer's Disease by Plasma Cholesterol: Rational In Silico Drug Investigation of Pyrrole-Based HMG-CoA Reductase Inhibitors.Assay Drug Dev Technol. 2017 Oct/Nov;15(7):342-351. doi: 10.1089/adt.2017.804. Epub 2017 Oct 27.
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No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.Neurosci Lett. 2011 Feb 4;489(2):119-21. doi: 10.1016/j.neulet.2010.11.078. Epub 2010 Dec 5.
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Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer's Disease.J Mol Neurosci. 2019 Apr;67(4):495-503. doi: 10.1007/s12031-018-1249-1. Epub 2019 Jan 4.
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Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of A Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model.Mol Neurobiol. 2020 Mar;57(3):1473-1483. doi: 10.1007/s12035-019-01827-y. Epub 2019 Nov 23.
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Overexpression of the Insulin-Like Growth Factor II Receptor Increases -Amyloid Production and Affects Cell Viability.Mol Cell Biol. 2015 Jul;35(14):2368-84. doi: 10.1128/MCB.01338-14. Epub 2015 May 4.
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Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.Neurology. 2018 Jan 23;90(4):e291-e297. doi: 10.1212/WNL.0000000000004854. Epub 2017 Dec 27.
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Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.Exp Gerontol. 2019 Jul 1;121:91-98. doi: 10.1016/j.exger.2019.04.003. Epub 2019 Apr 11.
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Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease.J Geriatr Psychiatry Neurol. 2019 Jul;32(4):211-220. doi: 10.1177/0891988719841728. Epub 2019 Apr 24.
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Critical Roles of IL-33/ST2 Pathway in Neurological Disorders.Mediators Inflamm. 2018 Feb 4;2018:5346413. doi: 10.1155/2018/5346413. eCollection 2018.
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Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis.J Cell Sci. 2020 Jan 10;133(5):jcs238030. doi: 10.1242/jcs.238030.
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Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET.Transl Neurodegener. 2019 Aug 27;8:25. doi: 10.1186/s40035-019-0168-6. eCollection 2019.
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Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.Exp Neurol. 2020 Feb;324:113115. doi: 10.1016/j.expneurol.2019.113115. Epub 2019 Nov 14.
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Deep brain stimulation of the nucleus basalis of Meynert attenuates early EEG components associated with defective sensory gating in patients with Alzheimer disease - a two-case study.Eur J Neurosci. 2020 Mar;51(5):1201-1209. doi: 10.1111/ejn.13749. Epub 2017 Nov 22.
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Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.J Alzheimers Dis. 2020;73(1):135-145. doi: 10.3233/JAD-190991.
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Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes.Front Neurosci. 2019 Mar 13;13:220. doi: 10.3389/fnins.2019.00220. eCollection 2019.
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The Role of Neuronal NLRP1 Inflammasome in Alzheimer's Disease: Bringing Neurons into the Neuroinflammation Game.Mol Neurobiol. 2019 Nov;56(11):7741-7753. doi: 10.1007/s12035-019-1638-7. Epub 2019 May 20.
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Drug likeness, targets, molecular docking and ADMET studies for some indolizine derivatives.Pharmazie. 2018 Nov 1;73(11):635-642. doi: 10.1691/ph.2018.8061.
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Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing.J Pharmacol Sci. 2018 Jun;137(2):146-153. doi: 10.1016/j.jphs.2018.05.004. Epub 2018 May 29.
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-Hydroxybutyrate Ameliorates A-Induced Downregulation of TrkA Expression by Inhibiting HDAC1/3 in SH-SY5Y Cells.Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317519883496. doi: 10.1177/1533317519883496. Epub 2019 Oct 24.
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Computational prediction of changes in brain metabolic fluxes during Parkinson's disease from mRNA expression.PLoS One. 2018 Sep 12;13(9):e0203687. doi: 10.1371/journal.pone.0203687. eCollection 2018.
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Association of lectin-like oxidized low density lipoprotein receptor 1 (OLR1) polymorphisms with late-onset Alzheimer disease in Han Chinese.Ann Transl Med. 2018 May;6(10):172. doi: 10.21037/atm.2018.04.31.
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The P2X7 receptor: a new therapeutic target in Alzheimer's disease.Expert Opin Ther Targets. 2019 Mar;23(3):165-176. doi: 10.1080/14728222.2019.1575811.
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Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease.Mol Neurobiol. 2010 Jun;41(2-3):73-86. doi: 10.1007/s12035-010-8107-7. Epub 2010 Mar 2.
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Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease.Neurobiol Dis. 2019 Jan;121:138-147. doi: 10.1016/j.nbd.2018.09.020. Epub 2018 Sep 26.
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Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target.Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):40-49. doi: 10.1111/bcpt.13094. Epub 2018 Aug 14.
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Physicochemical, Stress Degradation Evaluation and Pharmacokinetic Study of AZGH102, a New Synthesized COX2 Inhibitors after I.V. and Oral Administration in Male and Female Rats.Iran J Pharm Res. 2017 Spring;16(2):442-450.
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Development of Predictive Models for Identifying Potential S100A9 Inhibitors Based on Machine Learning Methods.Front Chem. 2019 Nov 25;7:779. doi: 10.3389/fchem.2019.00779. eCollection 2019.
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GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.Mol Neurobiol. 2020 Feb;57(2):798-805. doi: 10.1007/s12035-019-01743-1. Epub 2019 Aug 31.
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Lymphoblast-derived integration-free iPSC line AD-TREM2-1 from a 67year-old Alzheimer's disease patient expressing the TREM2 p.R47H variant.Stem Cell Res. 2018 May;29:60-63. doi: 10.1016/j.scr.2018.03.011. Epub 2018 Mar 20.
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Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment.Hum Mol Genet. 2017 Apr 15;26(8):1472-1482. doi: 10.1093/hmg/ddx051.
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Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer's patients.PLoS One. 2019 Sep 23;14(9):e0222921. doi: 10.1371/journal.pone.0222921. eCollection 2019.
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The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease.Brain Pathol. 2019 Jul;29(4):530-543. doi: 10.1111/bpa.12691. Epub 2019 Jan 28.
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Down-Regulation of Mir-107 Worsen Spatial Memory by Suppressing SYK Expression and Inactivating NF-B Signaling Pathway.Curr Alzheimer Res. 2019;16(2):135-145. doi: 10.2174/1567205016666181212154347.
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Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy.Hum Mol Genet. 2018 Aug 15;27(16):2874-2892. doi: 10.1093/hmg/ddy201.
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Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice.Iran J Basic Med Sci. 2017 Oct;20(10):1159-1165. doi: 10.22038/IJBMS.2017.9366.
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Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.Genet Mol Res. 2015 Aug 10;14(3):9361-9. doi: 10.4238/2015.August.10.17.
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Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer's disease and mild cognitive impairment patients.J Proteomics. 2018 Apr 30;178:73-81. doi: 10.1016/j.jprot.2017.12.018. Epub 2017 Dec 24.
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Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial.J Alzheimers Dis. 2019;72(4):1209-1216. doi: 10.3233/JAD-190757.
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Regulation of RAGE splicing by hnRNP A1 and Tra2-1 and its potential role in AD pathogenesis.J Neurochem. 2015 Apr;133(2):187-98. doi: 10.1111/jnc.13069. Epub 2015 Mar 2.
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No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases.Neurobiol Dis. 2006 May;22(2):323-33. doi: 10.1016/j.nbd.2005.11.010. Epub 2006 Jan 9.
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KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.Curr Neuropharmacol. 2018;16(5):618-626. doi: 10.2174/1570159X15666170630164226.
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Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer.Biochem Biophys Res Commun. 2019 Jan 22;508(4):1133-1138. doi: 10.1016/j.bbrc.2018.12.060. Epub 2018 Dec 13.
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A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer's Disease Risk by Modulating Both Amyloid- Pathology and Neuronal Degeneration.Front Neurosci. 2019 Jul 17;13:742. doi: 10.3389/fnins.2019.00742. eCollection 2019.
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Review: Vascular dementia: clinicopathologic and genetic considerations.Neuropathol Appl Neurobiol. 2018 Apr;44(3):247-266. doi: 10.1111/nan.12472. Epub 2018 Mar 1.
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Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3162-3167. doi: 10.1073/pnas.1706100115. Epub 2018 Mar 6.
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Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.Neurosci Lett. 2005 May 13;379(3):149-51. doi: 10.1016/j.neulet.2004.12.056. Epub 2005 Jan 25.
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Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation.Front Aging Neurosci. 2019 Jan 25;10:432. doi: 10.3389/fnagi.2018.00432. eCollection 2018.
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In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.Cell Mol Life Sci. 2018 Sep;75(17):3251-3267. doi: 10.1007/s00018-018-2791-2. Epub 2018 Mar 8.
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Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230. doi: 10.1016/j.bbamcr.2016.11.003. Epub 2016 Nov 3.
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Caenorhabditis elegans hub genes that respond to amyloid beta are homologs of genes involved in human Alzheimer's disease.PLoS One. 2019 Jul 10;14(7):e0219486. doi: 10.1371/journal.pone.0219486. eCollection 2019.
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Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.Transl Psychiatry. 2019 Jan 31;9(1):55. doi: 10.1038/s41398-019-0394-9.
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CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.Biochem Biophys Res Commun. 2017 Aug 26;490(3):876-881. doi: 10.1016/j.bbrc.2017.06.134. Epub 2017 Jun 21.
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Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample.Int J Geriatr Psychiatry. 2016 Dec;31(12):1337-1344. doi: 10.1002/gps.4440. Epub 2016 Feb 14.
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Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons.Genomics. 2018 Mar;110(2):98-111. doi: 10.1016/j.ygeno.2017.09.001. Epub 2017 Sep 11.
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Glial Draper Rescues A Toxicity in a Drosophila Model of Alzheimer's Disease.J Neurosci. 2017 Dec 6;37(49):11881-11893. doi: 10.1523/JNEUROSCI.0862-17.2017. Epub 2017 Nov 6.
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Genetics of Alzheimer's disease.Adv Genet. 2014;87:245-94. doi: 10.1016/B978-0-12-800149-3.00005-6.
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