General Information of Disease (ID: DISF8S70)

Disease Name Alzheimer disease
Synonyms Alzheimer disease, familial; Alzheimer dementia; AD; Alzheimers dementia; Alzheimer's disease; presenile and senile dementia; Alzheimer's dementia; Alzheimers disease; Alzheimer disease
Disease Class 8A20: Alzheimer disease
Definition A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
Disease Hierarchy
DISY2IPA: Tauopathy
DISXL1WY: Dementia
DISF8S70: Alzheimer disease
ICD Code
ICD-11
ICD-11: 8A20
ICD-10
ICD-10: G30, G30.9
ICD-9
ICD-9: 331
Expand ICD-11
'8A20
Expand ICD-10
'G30; 'G30.9
Expand ICD-9
331
Disease Identifiers
MONDO ID
MONDO_0004975
MESH ID
D000544
UMLS CUI
C0002395
MedGen ID
1853
HPO ID
HP:0002511
Orphanet ID
238616
SNOMED CT ID
26929004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 24 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Aducanumab DM51JW4 Approved NA [1]
Colostrinin DMN110U Approved NA [2]
Dihydroergotoxine DM5D6WZ Approved Small molecular drug [3]
Donepezil DMIYG7Z Approved Small molecular drug [4]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Approved Small molecular drug [5]
Ergoloid mesylate DMORPBA Approved Small molecular drug [6]
F18-florbetaben DMY5WFL Approved NA [7]
F18-flutemetamol DMT30LD Approved NA [8]
Galantamine DMEO794 Approved Small molecular drug [9]
GV-971 DMTMA5W Approved in China NA [10]
Huperzine A DMMAWLU Approved Small molecular drug [2]
Immune globulin DMX2OMJ Approved NA [11]
Lecanemab DMW03YD Approved Antibody [12]
Lemborexant DM3DGSG Approved NA [13]
Memantine DMD9WSC Approved Small molecular drug [14]
Nirogacestat DMUP5Z0 Approved Small molecular drug [15]
Pexidartinib DMS2J0Z Approved NA [16]
Propentofylline propionate DM6JQ2I Approved Small molecular drug [2]
Rivastigmine DMG629M Approved Small molecular drug [17]
Rosiglitazone XR DMT45MU Approved Small molecular drug [18]
Tacrine DM51FY6 Approved Small molecular drug [19]
Thiazolidinedione DMC1NBW Approved Small molecular drug [20]
18F-AV-1451 DM0GMH4 Phase 4 NA [21]
Guanfacine DMPN5IH Phase 4 NA [22]
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⏷ Show the Full List of 24 Drug(s)
This Disease is Treated as An Indication in 300 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
(-)-Phenserine DMNCY1I Phase 3 Small molecular drug [23]
AC-1204 DM3J99W Phase 3 Small molecular drug [13]
acelarin DMY96O3 Phase 3 Small molecular drug [24]
ALZT-OP1 DMG5BTD Phase 3 NA [13]
AMG 386 DMQJXL4 Phase 3 Small molecular drug [25]
AR1001 DMLV939 Phase 3 Small molecule [26]
ARC029 DMYNJHI Phase 3 Small molecular drug [27]
AV 133 DM0EQ9X Phase 3 NA [28]
AVP-786 DMV1SOR Phase 3 NA [29]
AXS-05 DM6WZG8 Phase 3 Small molecular drug [29]
Bapineuzumab DMHQ5GK Phase 3 Antibody [30]
BPDO-1603 DMJ82Y4 Phase 3 NA [31]
Crenezumab DM7QI29 Phase 3 Monoclonal antibody [13]
Davunetide DMD7K9X Phase 3 NA [32]
Donanemab DMPGLIO Phase 3 Monoclonal antibody [33]
E-2609 DMTNUJ8 Phase 3 NA [13]
Eltoprazine DMW6C81 Phase 3 Small molecular drug [13]
EVP-6124 DMLQO7F Phase 3 Small molecular drug [34]
Gantenerumab DMWX90U Phase 3 Monoclonal antibody [35]
INM-176 DMLG96Z Phase 3 NA [36]
Lanabecestat DMFJLB6 Phase 3 NA [13]
LCS 16 DMV5EYE Phase 3 NA [37]
LMT-X DMOFIBM Phase 3 NA [38]
MIM-D3 DMZHN5B Phase 3 Small molecular drug [39]
NE3107 DMEZNJI Phase 3 Small molecule [40]
NI-101 DMJ2KIE Phase 3 Antibody [41]
PF-4494700 DMJ7IKW Phase 3 Small molecular drug [13]
Remternetug DMPSMEU Phase 3 Antibody [42]
SB-742457 DM6L4ZT Phase 3 Small molecular drug [43]
SI-657 DM0QGFL Phase 3 Small molecular drug [44]
Solanezumab DM0HIU5 Phase 3 Monoclonal antibody [45]
Tamibarotene DM3G74J Phase 3 Small molecular drug [46]
Tirapazamine DMBFE4K Phase 3 Small molecular drug [47]
Tramiprosate DM7BSRH Phase 3 Small molecular drug [48]
TRx0237 DM0QNF4 Phase 3 Small molecular drug [49]
verubecestat DM4CGH5 Phase 3 Small molecular drug [43]
Xaliproden DM1JCW8 Phase 3 Small molecular drug [50]
AMG520 DMBFOAZ Phase 2/3 NA [43]
Atuzaginstat DM5T6BM Phase 2/3 Small molecule [51]
AZD3293 DMJQHXD Phase 2/3 Small molecular drug [52]
CAD-106 DM31VZT Phase 2/3 Vaccine [53]
CAD106 DMVJKNU Phase 2/3 Vaccine [54]
E2814 DMZ3Q59 Phase 2/3 Monoclonal antibody [55]
Fosgonimeton DMXMAJA Phase 2/3 Small molecule [56]
Ginkgo biloba DMJZBXX Phase 2/3 NA [57]
Icosapent ethyl DMKI68F Phase 2/3 Small molecule [58]
JNJ-54861911 DMGPJ5U Phase 2/3 NA [59]
Plasminogen DM0EFQS Phase 2/3 NA [60]
SI-614 DMJ3D6B Phase 2/3 NA [61]
AADvac-1 DMDLWW9 Phase 2 Vaccine [62]
ABBV-8E12 DMHLIQU Phase 2 NA [63]
ABBV-916 DMGSCJC Phase 2 Monoclonal antibody [64]
ABT-126 DM2OS51 Phase 2 NA [65]
ABT-288 DM7X54F Phase 2 Small molecular drug [66]
ABT-384 DM7XW5Y Phase 2 Small molecular drug [67]
ABvac40 DMWJE7B Phase 2 Vaccine [68]
AD-35 DMVDQO6 Phase 2 Small molecule [69]
AD02 vaccine DMZYQNL Phase 2 NA [70]
AL002 DMOY8VA Phase 2 Monoclonal antibody [71]
ALZ-801 DM7ZQAT Phase 2 NA [13]
AN-1792 DM3JNXS Phase 2 Small molecular drug [72]
APH-1105 DMT2IWF Phase 2 NA [73]
AQW-051 DMD2RFO Phase 2 Small molecular drug [74]
AUS-131 DMUXO3Z Phase 2 NA [13]
AVN 101 DMJFLBC Phase 2 NA [75]
AVN 322 DMK2LGM Phase 2 NA [76]
AZD-1446 DM7B1AR Phase 2 Small molecular drug [77]
AZD-5213 DMOZ04X Phase 2 NA [78]
AZD4694 DM6S9JP Phase 2 Small molecular drug [79]
Basmisanil DMQ8J0U Phase 2 NA [80]
Benfotiamine DMJHC2Y Phase 2 Small molecule [81]
Bepranemab DMRQIJO Phase 2 Monoclonal antibody [82]
BI-409306 DMJFDS0 Phase 2 NA [13]
BIIB092 DM263RP Phase 2 NA [13]
BMS-708163 DM51LTG Phase 2 Small molecular drug [83]
BPN14770 DMWVPO0 Phase 2 NA [84]
Bryostatin-1 DM1JOXY Phase 2 Small molecule [85]
CERE-110 DMNW5I9 Phase 2 NA [86]
CHF-5074 DMTE071 Phase 2 Small molecular drug [87]
Coluracetam DMI2GSK Phase 2 Small molecular drug [88]
CPC-201 DM10RQH Phase 2 NA [89]
CSTC1 DMM0D1Q Phase 2 NA [13]
CT1812 DMBRKZ7 Phase 2 NA [90]
CX-717 DMM65W1 Phase 2 Small molecular drug [91]
CY6463 DM84AVQ Phase 2 Small molecule [92]
DCB-AD1 DMBD9MQ Phase 2 NA [93]
DHP1401 DMH8HF9 Phase 2 NA [94]
DM-99 DM1HG3U Phase 2 NA [95]
E2027 DMK8SY6 Phase 2 Small molecular drug [13]
EVP-0962 DM0AO5W Phase 2 NA [96]
EVT302 DM73XNG Phase 2 NA [13]
FK-962 DMV0MZ3 Phase 2 Small molecular drug [97]
FRM-0962 DM9ORUW Phase 2 NA [98]
GM-602 DM8R4YU Phase 2 NA [99]
GSK239512 DMBJMZC Phase 2 Small molecular drug [100]
GSK933776A DMX27Q1 Phase 2 NA [101]
HF-0220 DMI4C90 Phase 2 NA [102]
HSRx-888 DM3S3AS Phase 2 NA [13]
ICA-17043 DMRFY7I Phase 2 Small molecular drug [103]
ID1201 DM3LHAX Phase 2 NA [104]
IMD-1041 DMU1MR9 Phase 2 NA [105]
JNJ-63733657 DMMKWGJ Phase 2 Monoclonal antibody [106]
JOT106 DMY56TP Phase 2 NA [43]
KPAX002 DMDT5WM Phase 2 NA [43]
Ladostigil DMJSY3Q Phase 2 Small molecular drug [107]
LY2886721 DMV14LM Phase 2 Small molecular drug [108]
LY3002813 DM2T6CY Phase 2 NA [109]
LY3202626 DM7IFNB Phase 2 NA [13]
LY3372689 DMA2M7V Phase 2 Small molecule [110]
LymPro DM9XV3C Phase 2 NA [111]
Mesenchymal stem cell therapy DMW7QYT Phase 2 NA [13]
Methanesulfonyl fluoride DMS7FRI Phase 2 Small molecular drug [112]
Mibampator DME5CSV Phase 2 Small molecular drug [113]
MIQ-001 DM6QADB Phase 2 NA [114]
Mitoglitazone DMIRPSA Phase 2 Small molecular drug [13]
MK-0752 DMLTAES Phase 2 Small molecular drug [115]
MK-1942 DMLD8DF Phase 2 Small molecule [116]
MK-7622 DM1Q18V Phase 2 Small molecular drug [117]
MLC901 DM67LGP Phase 2 NA [118]
MP-101 DMYCITZ Phase 2 NA [119]
MW150 DMBRVXB Phase 2 Small molecule [120]
Myo-inositol DMQKSGI Phase 2 Small molecular drug [29]
NDD-094 DMULYI3 Phase 2 NA [121]
Nefiracetam DMCMIYZ Phase 2 Small molecular drug [122]
Neu-P11 DMIQDFW Phase 2 Small molecular drug [13]
NIC5-15 DMG7XOC Phase 2 Small molecular drug [123]
NLY01 DMI9OMV Phase 2 Small molecule [124]
NP001 DMVB5E1 Phase 2 Small molecular drug [13]
Nuedexta DM9DO9B Phase 2 NA [13]
Nuplazid DMOJA5G Phase 2 Small molecular drug [125]
Oleoyl-estrone DM0RA8F Phase 2 Small molecular drug [13]
ORM-12741 DM8ARQW Phase 2 Small molecular drug [126]
ORY-2001 DMYM0UY Phase 2 Small molecule [127]
PBT-2 DMKWGS1 Phase 2 Small molecular drug [128]
PF-05212377 DMPVQYR Phase 2 NA [129]
PF-4447943 DM81D4I Phase 2 Small molecular drug [130]
Ponezumab DMIAZ13 Phase 2 Antibody [131]
PRX-3140 DMEVXS1 Phase 2 NA [132]
PTI-125 DMV17HK Phase 2 Small molecular drug [133]
R-phenserine DM4L5VJ Phase 2 NA [134]
RG1577 DMT1ZX0 Phase 2 NA [135]
RG6100 DMEFD0B Phase 2 NA [136]
RP5063 DMKUE8O Phase 2 NA [29]
RPh201 DM09NZU Phase 2 NA [137]
S-38093 DMD8XOY Phase 2 NA [138]
SAGE-718 DM9RC7D Phase 2 Small molecular drug [139]
SAM-531 DMHVJZ6 Phase 2 Small molecular drug [140]
SAR-110894 DMCLEXM Phase 2 NA [141]
Semorinemab DMA17VD Phase 2 Monoclonal antibody [142]
ST-101 DMVUXLC Phase 2 Small molecular drug [143]
SUVN-502 DMQD753 Phase 2 Small molecular drug [13]
SYN-120 DMPW0UL Phase 2 NA [144]
T-817MA DMD72F4 Phase 2 Small molecular drug [145]
T3D-959 DMR3245 Phase 2 NA [146]
Tau-binding PET tracer DM9QFW2 Phase 2 Small molecular drug [147]
TB006 DMKN524 Phase 2 Monoclonal antibody [148]
TD-8954 DM3C9NV Phase 2 Small molecular drug [149]
Tideglusib DME4LA1 Phase 2 Small molecular drug [150]
TPI 287 DM3I5NU Phase 2 NA [43]
TPI-287 DMC5TV6 Phase 2 Small molecular drug [151]
Trontinemab DMNCLHJ Phase 2 Antibody [152]
TTP-448 DMR37X8 Phase 2 NA [153]
UB-311 DM4NXWE Phase 2 NA [154]
UE-2343 DMIERPK Phase 2 NA [13]
Vafidemstat DM64ZGY Phase 2 Small molecule [127]
Vanutide cridificar DMU2K8A Phase 2 NA [155]
VI-1121 DMDI3B4 Phase 2 NA [156]
VX-745 DMJAEG6 Phase 2 Small molecular drug [13]
ACI-24 DM5YDSU Phase 1/2 Vaccine [157]
AL 001 DMSNCPD Phase 1/2 NA [158]
APH-0703 DMVD56K Phase 1/2 NA [159]
AstroStem DMAS46G Phase 1/2 NA [13]
BIIB080 DM6QH3U Phase 1/2 NA [13]
BIL010t DMV1EA9 Phase 1/2 NA [103]
EB-101 DMH2NKD Phase 1/2 Vaccine [160]
GB301 DMIPDDL Phase 1/2 Cell therapy [161]
IONIS-MAPTRx DM7H7KH Phase 1/2 NA [43]
LM11A-31 DM095HQ Phase 1/2 Small molecular drug [162]
LX1001 DMXEJZO Phase 1/2 Gene therapy [163]
MIB-626 DM6RTN3 Phase 1/2 NA [164]
MK-2461 DM21WBH Phase 1/2 Small molecular drug [165]
RVX-208 DM1LO8K Phase 1/2 Small molecular drug [166]
VAC20121 DMOH36A Phase 1/2 Vaccine [167]
VGH-AD1 DM4DPYS Phase 1/2 NA [168]
VLP norovirus bivalent vaccine DMGL85U Phase 1/2 NA [169]
Xanamem DM580GT Phase 1/2 Small molecule [170]
11C-6-Me-BTA-1 DMICUPT Phase 1 NA [171]
11C-AZD-2184 DMYVDXW Phase 1 NA [172]
123I-MNI-168 DM2GR7E Phase 1 NA [173]
123I-MNI-330 DMMBGH3 Phase 1 NA [174]
18F-FEDAA-1106 DMZ5YMX Phase 1 NA [175]
AAB-003/PF-05236812 DM92RQT Phase 1 NA [176]
AAD-2004 DMG4RK0 Phase 1 Small molecular drug [177]
AAV-hTERT DMV1J21 Phase 1 Gene therapy [178]
ABT-354 DMWN7D3 Phase 1 NA [179]
ABT-957 DMB9N4J Phase 1 NA [180]
ACI-35 DMIP79L Phase 1 NA [181]
ACU193 DM5BISI Phase 1 Antibody [182]
AD03 vaccine DMA20WE Phase 1 Vaccine [183]
AD101 DMJFNKZ Phase 1 Small molecule [184]
Affitope AD-01 DM0I8RZ Phase 1 Vaccine [185]
AL003 DMF6W5K Phase 1 Monoclonal antibody [186]
Aleplasinin DMYTIP4 Phase 1 Small molecular drug [187]
ALN-APP DME8BPN Phase 1 RNA interference [188]
ANAVEX 2-73 DM67OU4 Phase 1 NA [13]
Anti-N3pG-Abeta antibody DMRWI7E Phase 1 Antibody [189]
ANVS301 DMHT1AS Phase 1 NA [190]
APH-1104 DMVQI2A Phase 1 NA [191]
APNmAb005 DMDVRPZ Phase 1 Monoclonal antibody [192]
ARC031 DMFUEYP Phase 1 NA [193]
ASN51 DMZWOYL Phase 1 NA [194]
ASP-0777 DM8DBT6 Phase 1 NA [195]
ASP3662 DMQLLVL Phase 1 NA [196]
AV-965 DMVL87N Phase 1 NA [197]
AVN-322 DMNIVFJ Phase 1 Small molecular drug [198]
AZD-3839 DM72FOD Phase 1 Small molecular drug [199]
AZD2184 DMVDBS7 Phase 1 NA [200]
AZD2995 DMDVNVI Phase 1 NA [200]
BAY-1006578 DMEUW6I Phase 1 NA [201]
BCI-632 DMZYCWT Phase 1 Small molecular drug [202]
BCI-838 DMRXDN3 Phase 1 NA [203]
Begacestat DMUR49N Phase 1 Small molecular drug [204]
BEY2153 DMCB2Z0 Phase 1 NA [205]
BIIB076 DMOTBB4 Phase 1 NA [13]
BIIB113 DM7U1AC Phase 1 Small molecule [206]
BMS-241027 DM6GB6B Phase 1 NA [207]
BMS-932481 DMTJLJH Phase 1 NA [153]
BMS-984923 DMFNDUL Phase 1 Small molecule [208]
COR-388 DM0MFDA Phase 1 NA [13]
COR588 DMPGTC8 Phase 1 Small molecule [209]
CPC-212 DM3J1T9 Phase 1 NA [13]
CPC-250 DMDQG4Y Phase 1 NA [13]
CTS-21166 DM68I93 Phase 1 NA [210]
DNL104 DMOSCQ9 Phase 1 Small molecular drug [211]
DNL747 DMNSC0O Phase 1 Small molecular drug [212]
DNL919 DMDFQLZ Phase 1 Antibody [213]
DSP-8658 DM2PYE0 Phase 1 NA [214]
DWP-09031 DM4XZY9 Phase 1 NA [215]
E-2212 DMQDKYV Phase 1 NA [216]
E2012 DMNEVKA Phase 1 Small molecular drug [217]
E2511 DM5GE7H Phase 1 NA [218]
Exebryl-1 DM5U0K9 Phase 1 NA [219]
FGLL DMY61GX Phase 1 NA [220]
GC021109 DMQBEYV Phase 1 NA [13]
GRF6019 DMVYEBN Phase 1 NA [13]
GSI-136 DMSR5HD Phase 1 Small molecular drug [221]
GSK2647544 DM3KARJ Phase 1 NA [222]
GSK2981710 DM7DBFF Phase 1 NA [223]
HPP-854 DMSLDHG Phase 1 NA [224]
IGCAD1 DMB3PVV Phase 1 NA [225]
J147 DMMWX7N Phase 1 Small molecule [226]
JES-9501 DMYR3IE Phase 1 NA [227]
Lu AF20513 DM40FFG Phase 1 NA [13]
Lu AF87908 DMFSPAT Phase 1 Monoclonal antibody [228]
LY-2811376 DM8LGWR Phase 1 Small molecular drug [229]
LY3303560 DMG6HLE Phase 1 NA [43]
LY3372993 DMACGI7 Phase 1 Monoclonal antibody [230]
MCD-386 DMFIS4D Phase 1 NA [231]
MEDI1814 DM078GU Phase 1 NA [13]
MEDI1841 DMLQOD3 Phase 1 NA [232]
MER5101 DMZ2D7H Phase 1 Vaccine [13]
MK-3328 DMW2O5D Phase 1 Small molecular drug [233]
MK-4334 DMQEQ33 Phase 1 NA [234]
NDX-1017 DM6NF5F Phase 1 NA [13]
NGP 555 DMTVQH2 Phase 1 NA [43]
NNI-362 DMPCV65 Phase 1 Small molecule [235]
NPT088 DM157TU Phase 1 NA [13]
NsG-0202 DM1ITDN Phase 1 NA [236]
NTRX-07 DMF8AHP Phase 1 NA [237]
Palomid-529 DM428Y3 Phase 1 NA [238]
PF-04995274 DMZ8QRI Phase 1 Small molecular drug [239]
PF-05251749 DMXLJJ6 Phase 1 NA [43]
PF-06648671 DM056JD Phase 1 Small molecular drug [240]
PF-06751979 DMEOF7Q Phase 1 NA [43]
Posiphen R-phenserine DMCU54M Phase 1 NA [241]
Protexia DME1Y9W Phase 1 NA [242]
Protollin DMBUU86 Phase 1 Vaccine [243]
PRX-005 DMAL2OW Phase 1 Antibody [244]
PTI-80 DM0A6N9 Phase 1 NA [245]
PU-AD DMKSU35 Phase 1 NA [13]
REM0046127 DMO4AJZ Phase 1 Small molecule [246]
RG6289 DMGLW0N Phase 1 NA [247]
RG7129 DMTWSM2 Phase 1 NA [248]
RVT-104 DM1INL2 Phase 1 NA [13]
SAR228810 DMTFAGU Phase 1 Antibody [249]
SGC-1061 DMLZY28 Phase 1 NA [250]
SHR-1707 DMCESPF Phase 1 Monoclonal antibody [251]
SOR-C13 DMBKL6O Phase 1 NA [103]
SPI-014 DM5IPUS Phase 1 NA [252]
SUVN-D4010 DM6ZOD2 Phase 1 NA [13]
TAK-071 DMKUT08 Phase 1 NA [13]
TAu mAb DMCZA4S Phase 1 NA [13]
TT-301 DM4QV8Y Phase 1 NA [253]
TTP-4000 DMCG01R Phase 1 NA [254]
V950 vaccine DMBJOKG Phase 1 NA [255]
XEL 001HP DM828IK Phase 1 NA [256]
alpha-ketothiazole analogue 36 DMN2I3P Clinical trial Small molecular drug [257]
bimatoprost (free acid form) DM531SA Clinical trial Small molecular drug [258]
JNJ-479655 DMDU6GN Clinical trial Small molecular drug [259]
methyl 5-[(4-tert-butylbenzoyl)amino]-2H-1,2,4-triazole-3-carboxylate DMW15TC Clinical trial Small molecular drug [260]
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⏷ Show the Full List of 300 Drug(s)
This Disease is Treated as An Indication in 9 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
PMID27998201-Compound-2 DMMAE3C Patented Small molecular drug [261]
PMID27998201-Compound-22 DMS9QA7 Patented Small molecular drug [261]
PMID28350212-Compound-18 DMH8GC6 Patented Small molecular drug [262]
PMID28350212-Compound-19 DMI4US6 Patented Small molecular drug [262]
PMID28350212-Compound-20 DMM5G7S Patented Small molecular drug [262]
PMID29334795-Compound-22 DM8N10A Patented Small molecular drug [263]
Schiff base compound 1 DMQD6IL Patented Small molecular drug [264]
Schiff base compound 2 DMWD20L Patented Small molecular drug [264]
Thiadiazolyl carboxamide derivative 1 DMX93AI Patented Small molecular drug [265]
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⏷ Show the Full List of 9 Drug(s)
This Disease is Treated as An Indication in 66 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
PF-1913539 DMXEU14 Discontinued in Phase 3 Small molecular drug [266]
Zanapezil DMTCP8H Discontinued in Phase 3 Small molecular drug [267]
ABT-418 DMNP72I Discontinued in Phase 2 Small molecular drug [268]
Affitope AD-02 DMSF5VK Discontinued in Phase 2 Vaccine [269]
AVN 397 DMFCOZL Discontinued in Phase 2 NA [270]
AZD0328 DM4B7CM Discontinued in Phase 2 Small molecular drug [271]
DPC-543 DMSZHNB Discontinued in Phase 2 NA [272]
IPENOXAZONE DM4WJDK Discontinued in Phase 2 Small molecular drug [273]
Ispronicline DMKY2UE Discontinued in Phase 2 Small molecular drug [274]
NGD-97-1 DMBF46A Discontinued in Phase 2 NA [275]
S-18986 DMA01BV Discontinued in Phase 2 Small molecular drug [276]
SIB-1553A DM7XC0U Discontinued in Phase 2 Small molecular drug [277]
Talsaclidine fumarate DM2KH9Y Discontinued in Phase 2 Small molecular drug [278]
AZD-1080 DMIM9N1 Discontinued in Phase 1 Small molecular drug [279]
C-9138 DML1OY7 Discontinued in Phase 1 NA [280]
EVT-301 DMCZ8SF Discontinued in Phase 1 NA [281]
GR-253035 DMWY2F6 Discontinued in Phase 1 NA [282]
NP-61 DMXI5YW Discontinued in Phase 1 NA [283]
PF-05236812 DM68PYA Discontinued in Phase 1 NA [284]
SL-25.1188 DMP0DLW Discontinued in Phase 1 NA [285]
TAK-065 DMWY2RH Discontinued in Phase 1 NA [286]
TRx-0037 DMMKSST Discontinued in Phase 1 NA [287]
VP-025 DM0HZBU Discontinued in Phase 1 NA [288]
A-72055 DM7FI3S Terminated NA [300]
ABS-301 DMCW5DJ Terminated NA [301]
Alvameline DMLN0Y5 Terminated Small molecular drug [302]
AZD-2858 DMRCI96 Terminated Small molecular drug [303]
BIBN-140 DM019Y7 Terminated Small molecular drug [304]
BIBN-99 DMZTPCX Terminated Small molecular drug [305]
Bifemelane DMU73F0 Terminated Small molecular drug [306]
BU-4514N DMJDMTK Terminated Small molecular drug [307]
CEP-427 DMTI10C Terminated NA [308]
CEP-431 DMDH0AM Terminated NA [309]
CI-1002 DMJ2P1Q Terminated NA [310]
DNP-004089 DMXR3V1 Terminated NA [311]
EHT-1864 DMYAMP5 Terminated Small molecular drug [312]
F-14413 DMGH3QD Terminated NA [313]
F-3796 DMXB8SE Terminated NA [314]
FR-121196 DMNRUGA Terminated Small molecular drug [315]
FR-152558 DMOEYX2 Terminated NA [316]
GT-2016 DM42XHS Terminated Small molecular drug [317]
GT-4001 DMYNZB7 Terminated NA [318]
GYKI-52466 DM3YG5P Terminated Small molecular drug [319]
IDRA-21 DMG1FQW Terminated Small molecular drug [320]
L-698544 DMLRBN1 Terminated Small molecular drug [321]
MDL-28170 DMYK31O Terminated Small molecular drug [322]
MF-8615 DM47WS2 Terminated NA [323]
MF268 DMHV5OD Terminated Small molecular drug [324]
Milacemide DMJTR0U Terminated Small molecular drug [325]
Nerve growth factor DMHYQ8K Terminated NA [326]
NNC-90-0270 DM1SXG9 Terminated NA [327]
NP-7557 DM4B1VF Terminated NA [328]
NS-377 DM2MU98 Terminated NA [329]
NS-649 DMXKMRV Terminated NA [330]
R-1315 DMIBCZ5 Terminated NA [331]
Ro-46-5934 DMU9JAH Terminated NA [332]
RS 86 DMKQV9A Terminated Small molecular drug [333]
RS-66252 DMT5DH0 Terminated NA [334]
RU-33965 DMSWFMQ Terminated Small molecular drug [335]
SAN-61 DMGUA9Y Terminated NA [336]
Sch-57790 DMGCYPE Terminated Small molecular drug [337]
Sibopirdine DMGZDOA Terminated Small molecular drug [338]
Tenilsetam DMNEF2N Terminated Small molecular drug [339]
Z-4105 DM2F6T0 Terminated Small molecular drug [340]
ZK-91296 DMJYIVA Terminated Small molecular drug [341]
ZK-93426 DMMDQ5T Terminated Small molecular drug [342]
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⏷ Show the Full List of 66 Drug(s)
This Disease is Treated as An Indication in 15 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AAB-002 DMC7EQT Phase 0 NA [289]
ACC-002 DMTYPNN Phase 0 NA [290]
INP102 DMPIWDL Phase 0 NA [13]
ANAVEX 1-41 DM1MQON Preclinical NA [291]
CDD-0199-J DM842EE Preclinical NA [292]
CX-1501 DMKZCBE Preclinical NA [293]
humanin DMUAPNF Preclinical Small molecular drug [294]
Pepticlere DMA5T3J Preclinical NA [295]
SCH-1359113 DMLG682 Preclinical Small molecular drug [296]
SD1002 DMLAF6C Preclinical Small molecular drug [297]
SD1003 DM29BW1 Preclinical Small molecular drug [297]
SPH-1285 DMMA2ZW Preclinical NA [298]
TPT-43 DM06BUL Preclinical NA [299]
VER-155008 DMIQAY4 Preclinical Small molecular drug [297]
Z-Phe-Ala-diazomethylketone DMX23CZ Preclinical Small molecular drug [297]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 Drug(s)
This Disease is Treated as An Indication in 72 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
11A1 DMFVP6K Investigative Antibody [160]
123I-DRM-106 DMW172Q Investigative Small molecular drug [160]
A-887755 DM8IWUE Investigative NA [160]
Abloid DMKN10X Investigative NA [160]
AC-4402 DMDAM9P Investigative Small molecular drug [343]
ACI-518 DM1O13Z Investigative NA [343]
ACI-636 DMPLNTM Investigative NA [160]
ACU-0101979 DM7ZWRN Investigative Vaccine [160]
AD-0802 DM23QND Investigative Vaccine [160]
ADepVac DM9KPHE Investigative NA [343]
AIKb2 DM6Z14C Investigative NA [343]
ANA-5 DM3DPSO Investigative NA [160]
Anticalin DMQJ3ZL Investigative NA [160]
ARC-069 DMSM1PV Investigative NA [160]
ARN-2966 DMBE0H8 Investigative Small molecular drug [344]
AZ-AAV9 DMPWF71 Investigative NA [343]
AZD-6319 DMD4YO9 Investigative NA [345]
AZP-2006 DMZFEKB Investigative NA [343]
BAN-2203 DMX6KTO Investigative NA [160]
CBNU-06 DMC3H8P Investigative NA [343]
CDD-0235-J DMEG8TG Investigative NA [343]
CDD-190 DML6489 Investigative NA [343]
COG-248 DM0E4YT Investigative NA [343]
CWF-0804 DMB8BHX Investigative NA [343]
Cystatin C DMHLLCB Investigative NA [343]
DBT-1339 DM09YI7 Investigative NA [160]
DWJ-209 DMNWGWI Investigative NA [343]
EDN-OL1 DMHCGIS Investigative NA [160]
ELND-007 DM5G1SF Investigative Small molecular drug [346]
ESN-XX DMKLQ1N Investigative NA [343]
ETN-001 DMCND90 Investigative NA [343]
EVP-4473 DMHMFKE Investigative NA [345]
F-18 T808 DM0BZWR Investigative NA [343]
Gamma-secretase modulators DMG7UPR Investigative Small molecular drug [347]
Ginkgo biloba extract DMKIDQO Investigative NA [343]
GRL-11097 DMYQIQY Investigative NA [343]
GT 1061 DMR4I8K Investigative NA [343]
Haw-AD-14 DMDGSHS Investigative NA [343]
HL-026 DM8BM5M Investigative NA [343]
IMD-4482 DMSD7YJ Investigative NA [343]
KD-501 DMIHJSE Investigative NA [343]
KD-901 DMB8LZ5 Investigative NA [343]
KMS-88009 DM2K81B Investigative NA [160]
KNX-Monoclonal204 DMNWXCA Investigative Antibody [160]
Leptin DM5LY1H Investigative NA [348]
LNK-3186 DM0MQ96 Investigative NA [343]
LNK-3248 DME7DX6 Investigative NA [343]
Memex DMMKAOE Investigative NA [343]
Mimovax DM7DT20 Investigative Vaccine [160]
Molecule 22 DM9K6Q4 Investigative NA [343]
NAChR alpha 7 APLs DMO5UJZ Investigative NA [343]
NAChR APLs DMKRFPW Investigative NA [343]
NGN-9079 DMNF845 Investigative NA [343]
NNI-AD DM6RZPM Investigative NA [343]
NP-103 DMPEDJG Investigative NA [343]
NP-17 DMY3NLW Investigative NA [343]
NXD-9062 DMOYQJY Investigative NA [343]
PD-2015 DM32UIG Investigative NA [343]
PN-403 DMX1LT7 Investigative NA [343]
PNB-04 DM4JRGT Investigative NA [343]
RAP-310 DMP2DMB Investigative NA [349]
RECALL-VAX DM1XFE9 Investigative Vaccine [160]
ReN-004 DMC8DY5 Investigative NA [343]
SEL-103 DMW97WY Investigative NA [343]
SEN-1500 DMKB2IJ Investigative NA [160]
SP-08 DM2TRIZ Investigative NA [160]
SPI-017 DMOOQ85 Investigative NA [343]
SX-AZD1 DM1KH2W Investigative NA [343]
TKP-1001 DMDBUXR Investigative NA [160]
Turmeric extracts DM3QE8P Investigative NA [160]
UC-1011 DMCRFT5 Investigative NA [350]
VK-11 DM7FQD0 Investigative NA [160]
------------------------------------------------------------------------------------
⏷ Show the Full List of 72 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 854 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ACAT1 TTK3C21 Limited Biomarker [351]
AGTR1 TT8DBY3 Limited Biomarker [352]
ANK1 TTKFPMH Limited Posttranslational Modification [353]
ANPEP TTPHMWB Limited Biomarker [354]
AQP1 TTSF1KH Limited Biomarker [355]
BLVRA TTJBPN3 Limited Posttranslational Modification [356]
C5AR1 TTHXFA1 Limited Biomarker [357]
CASR TTBUYHA Limited Biomarker [358]
CAV1 TTXUBN2 Limited Biomarker [359]
CCL11 TTCF05Y Limited Altered Expression [360]
CD40LG TTIJP3Q Limited Altered Expression [361]
CHRNA7 TTLA931 Limited Genetic Variation [362]
CRHR1 TT7EFHR Limited Biomarker [363]
CSNK1D TTH30UI Limited Biomarker [364]
CX3CR1 TT2T98G Limited Biomarker [365]
CYP3A4 TTWP7HQ Limited Genetic Variation [366]
ECE2 TT5U914 Limited Autosomal dominant [367]
EGR1 TTE8LGD Limited Altered Expression [368]
FKBP4 TTHY0FT Limited Biomarker [369]
FKBP5 TT0J5KQ Limited Biomarker [370]
FLT1 TT1VAUK Limited Altered Expression [371]
FUS TTKGYZ9 Limited Biomarker [372]
GLO1 TTV9A7R Limited Biomarker [373]
GNE TT4DP5S Limited Genetic Variation [374]
GPRC6A TTI1PRE Limited Biomarker [375]
GRIN2A TTKJEMQ Limited Altered Expression [376]
GSN TTUH7OM Limited Biomarker [377]
HLA-DRB1 TTUXSTW Limited Genetic Variation [378]
HMGA1 TTBA219 Limited Genetic Variation [379]
HMGCR TTPADOQ Limited Biomarker [380]
HNMT TT2B6EV Limited Genetic Variation [381]
IFNB1 TT4TZ8J Limited Biomarker [382]
IGF1 TTT6LOU Limited Altered Expression [383]
IGF2R TTPNE41 Limited Biomarker [384]
IGFBP3 TTZHNQA Limited Biomarker [385]
IL13 TT0GVCH Limited Altered Expression [386]
IL1RN TT6GSR3 Limited Biomarker [387]
IL33 TT5MD4P Limited Biomarker [388]
INPP5D TTTP2Z1 Limited Biomarker [389]
KLK6 TTLPF4X Limited Biomarker [390]
KLK8 TTH5MRS Limited Biomarker [391]
LPAR3 TTE2YJR Limited Biomarker [375]
LRP2 TTPH1AJ Limited Biomarker [392]
MAOB TTGP7BY Limited Genetic Variation [393]
MARK2 TTAJ45Y Limited Genetic Variation [394]
MRGPRX1 TTIX6PK Limited Biomarker [375]
NLRP1 TTQX29T Limited Biomarker [395]
NR1I2 TT7LCTF Limited Biomarker [396]
NRG1 TTEH395 Limited Altered Expression [397]
NTRK1 TTTDVOJ Limited Biomarker [398]
OGDH TTH8T6I Limited Altered Expression [399]
OLR1 TTKSND3 Limited Genetic Variation [400]
OXER1 TT7WBSV Limited Biomarker [375]
P2RX7 TT473XN Limited Biomarker [401]
PLA2G2A TTO8QRU Limited Biomarker [402]
PPID TTNAFOU Limited Biomarker [403]
PPIF TTRFQTB Limited Biomarker [403]
PREP TTNGKET Limited Biomarker [404]
PTGS1 TT8NGED Limited Biomarker [405]
S100A9 TT0TMQG Limited Biomarker [406]
SLC2A4 TTP6MT5 Limited Altered Expression [407]
SOX2 TTCNOT6 Limited Genetic Variation [408]
SOX5 TTXHSZK Limited Genetic Variation [409]
SP1 TTZEP6S Limited Biomarker [410]
SREBF2 TTRQ4AP Limited Biomarker [411]
SYK TT2HUPM Limited Biomarker [412]
TKT TT04R7I Limited Biomarker [413]
TRPV1 TTMI6F5 Limited Altered Expression [414]
VCAM1 TTHCEF6 Limited Biomarker [415]
VDAC1 TTAMKGB Limited Altered Expression [416]
ASRGL1 TT4WT91 Disputed Biomarker [417]
ADAM17 TT6AZXG moderate Genetic Variation [418]
CDA TTQ12RK moderate Biomarker [419]
CHRNB2 TT5KPZR moderate Biomarker [420]
CSF1R TT7MRDV moderate Biomarker [421]
DNM1 TTE3JW9 moderate Altered Expression [422]
ERN1 TTKIAT3 moderate Altered Expression [423]
HSF1 TTN6STZ moderate Altered Expression [424]
LGR5 TTTSGRH moderate Biomarker [425]
PTGES TTYLQ8V moderate Biomarker [426]
SLC6A3 TTVBI8W moderate Biomarker [427]
STAR TTEI40H moderate Biomarker [428]
VCP TTHNLSB moderate Genetic Variation [429]
AAK1 TT0Z32T Strong Altered Expression [430]
ABCA4 TTLB52K Strong Genetic Variation [431]
ABCB1 TT3OT40 Strong Biomarker [432]
ABCB11 TTUXCAF Strong Genetic Variation [433]
ABCC4 TTUEAFL Strong Altered Expression [434]
ABCC9 TTEF5MJ Strong Genetic Variation [435]
ABCG1 TTMWDGU Strong Biomarker [436]
ABCG2 TTIMJ02 Strong Biomarker [437]
ACE2 TTUI5H7 Strong Biomarker [438]
ACKR1 TTKY2NS Strong Biomarker [439]
ACKR3 TTRQJTC Strong Biomarker [440]
ACO2 TTMTF2P Strong Altered Expression [441]
ACTG1 TTGAZF9 Strong Biomarker [361]
ACVRL1 TTGYPTC Strong Biomarker [442]
ADAM30 TTAJDQY Strong Biomarker [443]
ADAM9 TTTYQNS Strong Biomarker [444]
ADAMTS1 TTS2TEI Strong Biomarker [445]
ADAMTS13 TTUREBK Strong Altered Expression [446]
ADAMTS4 TTYG6BU Strong Biomarker [447]
ADCY2 TTBQ9IM Strong Altered Expression [448]
ADCYAP1 TTW4LYC Strong Biomarker [449]
ADM TTV14YH Strong Altered Expression [450]
ADORA1 TTK25J1 Strong Biomarker [451]
ADORA2A TTM2AOE Strong Biomarker [452]
ADRA1A TTNGILX Strong Biomarker [440]
ADRA2A TTWG9A4 Strong Biomarker [453]
ADRA2B TTWM4TY Strong Biomarker [440]
ADRB1 TTR6W5O Strong Biomarker [454]
ADRB2 TTG8ZWP Strong Biomarker [455]
AGTR2 TTQVOEI Strong Biomarker [456]
AHSG TTKF4WV Strong Biomarker [457]
AIMP2 TTXWHGF Strong Biomarker [458]
ALAD TTJHKYD Strong Altered Expression [459]
ALAS1 TTG1FXO Strong Altered Expression [460]
ALOX12 TT12ABZ Strong Biomarker [461]
ALOX15 TTN9T81 Strong Altered Expression [462]
ALOX5AP TTDMBF5 Strong Genetic Variation [463]
ALPI TTHYMUV Strong Genetic Variation [464]
AMD1 TTBFROQ Strong Biomarker [465]
ANG TTURHFP Strong Biomarker [466]
ANGPT1 TTWNQ1T Strong Altered Expression [438]
ANXA1 TTUCK4B Strong Biomarker [467]
ANXA5 TT2Z83I Strong Genetic Variation [468]
AOC3 TT7HC21 Strong Biomarker [469]
APC2 TTSMK36 Strong Biomarker [470]
APCS TTB7VAT Strong Biomarker [471]
APEH TTYWEDQ Strong Biomarker [472]
APEX1 TTHGL48 Strong Genetic Variation [473]
APLN TT87D3J Strong Altered Expression [474]
APOA1 TT5S8DR Strong Biomarker [475]
APOA2 TTGQA9W Strong Biomarker [476]
APOA4 TTNC3WS Strong Biomarker [477]
APOC3 TTXOZQ1 Strong Biomarker [478]
AQP9 TTQEI32 Strong Biomarker [479]
ARG1 TT7ZQEV Strong Biomarker [480]
ARG2 TTV1AG6 Strong Genetic Variation [481]
ARRB1 TTMVD4A Strong Biomarker [482]
ARRB2 TT8SO2I Strong Biomarker [482]
ARSA TTYQANR Strong Genetic Variation [483]
ASIC2 TTVMWLP Strong Biomarker [484]
ASPA TT6TLZP Strong Biomarker [485]
ATF4 TTQCKWT Strong Altered Expression [486]
ATIC TT9NVXQ Strong Altered Expression [487]
ATP4A TTF1QVM Strong Biomarker [488]
ATXN3 TT6A17J Strong Biomarker [489]
AVPR2 TTK8R02 Strong Biomarker [490]
BACH1 TT2ME4S Strong Biomarker [491]
BAK1 TTFM7V0 Strong Altered Expression [492]
BAX TTQ57WJ Strong Therapeutic [493]
BCKDK TT7WD2Q Strong Genetic Variation [494]
BCL2 TTFOUV4 Strong Altered Expression [495]
BCL2A1 TTGT9C7 Strong Genetic Variation [496]
BCL2L2 TTQ79W8 Strong Therapeutic [497]
BDKRB2 TTGY8IW Strong Altered Expression [498]
BECN1 TT5M7LN Strong Biomarker [499]
BGN TT0JPVF Strong Biomarker [500]
BMP1 TT0L58T Strong Biomarker [501]
BMP4 TTD3BSX Strong Biomarker [502]
BMP6 TT07RIB Strong Biomarker [503]
BRCA2 TTUARD6 Strong Genetic Variation [504]
BRD3 TTHE657 Strong Biomarker [505]
BRS3 TTKYEPM Strong Biomarker [440]
BRSK1 TTV6WMQ Strong Genetic Variation [506]
BRSK2 TTHZN4X Strong Genetic Variation [506]
BSG TT5UJWD Strong Altered Expression [507]
C1QBP TTWTD7F Strong Biomarker [508]
C3 TTJGY7A Strong Biomarker [509]
C3AR1 TTI6B3F Strong Genetic Variation [510]
C5 TTKANGO Strong Biomarker [511]
C9orf72 TTA4SHR Strong Biomarker [512]
CA2 TTANPDJ Strong Biomarker [513]
CACNA1C TTZIFHC Strong Altered Expression [514]
CACNA1G TT729IR Strong Genetic Variation [515]
CAD TT2YT1K Strong Biomarker [516]
CALCA TTVSFJW Strong Biomarker [517]
CALCR TTLWS2O Strong Biomarker [518]
CAMKK2 TTV298Y Strong Biomarker [519]
CAMP TTULOB6 Strong Biomarker [520]
CAPN1 TT1WBIJ Strong Biomarker [521]
CAPN2 TTG5QB7 Strong Biomarker [522]
CASP1 TTCQIBE Strong Biomarker [523]
CASP2 TT12VNG Strong Biomarker [524]
CASP4 TT6KIOT Strong Altered Expression [525]
CASP7 TTM7Y45 Strong Biomarker [526]
CASP8 TT6SZNG Strong Biomarker [527]
CASP9 TTB6T7O Strong Therapeutic [528]
CCKAR TTCG0AL Strong Biomarker [529]
CCL21 TTLZK1U Strong Biomarker [530]
CCL3 TT8I4WB Strong Biomarker [531]
CCL5 TT9DWLC Strong Altered Expression [532]
CCNE2 TTLDRGX Strong Altered Expression [533]
CCR2 TTFZYTO Strong Biomarker [534]
CCR3 TTD3XFU Strong Biomarker [535]
CD200 TT0BE68 Strong Biomarker [536]
CD209 TTBXIM9 Strong Biomarker [537]
CD320 TT0KV32 Strong Genetic Variation [538]
CD36 TTPJMCU Strong Genetic Variation [539]
CD38 TTPURFN Strong Biomarker [540]
CD40 TT1ERKL Strong Biomarker [541]
CD46 TTMS7DF Strong Biomarker [542]
CD47 TT28S46 Strong Genetic Variation [464]
CD55 TT5Z9WY Strong Genetic Variation [543]
CD59 TTBGTEJ Strong Altered Expression [544]
CD69 TTPQE9F Strong Biomarker [540]
CD74 TTCMYP9 Strong Biomarker [508]
CD80 TT89Z17 Strong Biomarker [537]
CDC25B TTR0SWN Strong Biomarker [545]
CDC25C TTESBNC Strong Biomarker [546]
CDH2 TT1WS0T Strong Altered Expression [547]
CDK1 TTH6V3D Strong Altered Expression [548]
CDK18 TTUMFAR Strong Biomarker [549]
CDK5 TTL4Q97 Strong Biomarker [550]
CDK9 TT1LVF2 Strong Altered Expression [551]
CEBPB TTUI35N Strong Altered Expression [552]
CES1 TTMF541 Strong Biomarker [553]
CFB TTA0P7K Strong Genetic Variation [554]
CFD TT8D13I Strong Biomarker [555]
CFI TT6ATLX Strong Biomarker [556]
CFLAR TTJZQYH Strong Biomarker [557]
CGA TTFC29G Strong Biomarker [558]
CGB3 TTUH273 Strong Biomarker [558]
CHEK1 TTTU902 Strong Biomarker [559]
CHIT1 TTDYX6T Strong Biomarker [560]
CHN2 TT39YVO Strong Genetic Variation [561]
CHRM1 TTZ9SOR Strong Biomarker [562]
CHRM2 TTYEG6Q Strong Genetic Variation [563]
CHRM3 TTQ13Z5 Strong Biomarker [564]
CHRNA2 TTF4E0J Strong Genetic Variation [378]
CHRNA4 TT4H1MQ Strong Biomarker [565]
CIT TT3BKTU Strong Biomarker [566]
CLCF1 TTI6V13 Strong Altered Expression [567]
CLCN3 TT8XNZ7 Strong Biomarker [568]
CLK1 TTE6YDG Strong Biomarker [569]
CLK2 TT85TPS Strong Biomarker [570]
CLN3 TTORF9W Strong Genetic Variation [571]
CNP TT71P0H Strong Genetic Variation [572]
CNR1 TT6OEDT Strong Biomarker [573]
CNR2 TTMSFAW Strong Altered Expression [574]
CNTF TTGEM5Q Strong Altered Expression [575]
CNTFR TTT2F9E Strong Biomarker [575]
CNTN1 TTPR8FK Strong Biomarker [468]
CNTN2 TT2Z1WB Strong Biomarker [576]
COASY TT4YO0Z Strong Biomarker [577]
COPS5 TTSTNJR Strong Biomarker [578]
CPB1 TT4UJX5 Strong Biomarker [579]
CPE TTXPWO6 Strong Genetic Variation [580]
CPN1 TT8V2KD Strong Genetic Variation [581]
CPS1 TT42M75 Strong Genetic Variation [582]
CREB1 TTH4AN3 Strong Altered Expression [583]
CRHBP TT3PKZE Strong Biomarker [584]
CRK TTFEUYR Strong Biomarker [458]
CRTC1 TT4GO0F Strong Altered Expression [585]
CRYAB TT7RUHB Strong Altered Expression [586]
CRYZ TTP6UO8 Strong Genetic Variation [587]
CS TTZA6B3 Strong Biomarker [588]
CSE1L TTTRULD Strong Biomarker [589]
CSF1 TT0IQER Strong Altered Expression [590]
CSF2RB TTPYS82 Strong Biomarker [591]
CSF3R TTC70AJ Strong Biomarker [592]
CSNK1E TTA8PLI Strong Biomarker [593]
CSNK1G2 TT0UZJ9 Strong Biomarker [594]
CSNK1G3 TT34L5N Strong Biomarker [594]
CSNK2A1 TTER6YH Strong Altered Expression [595]
CSPG4 TT7MYXI Strong Biomarker [596]
CTCFL TTY0RZT Strong Genetic Variation [597]
CTF1 TTXGTZU Strong Biomarker [598]
CTNS TT1W2ZS Strong Biomarker [543]
CTSB TTF2LRI Strong Altered Expression [599]
CTSK TTDZN01 Strong Biomarker [600]
CTSS TTUMQVO Strong Biomarker [601]
CX3CL1 TT1OFBQ Strong Biomarker [365]
CXCL11 TTWG0RE Strong Biomarker [602]
CXCL2 TTZF0K2 Strong Biomarker [603]
CXCR1 TTMWT8Z Strong Biomarker [535]
CXCR2 TT30C9G Strong Biomarker [604]
CXCR6 TT2BVUA Strong Biomarker [440]
CYBB TT5T8MR Strong Biomarker [605]
CYP11A1 TTSYVO6 Strong Genetic Variation [606]
CYP17A1 TTRA5BZ Strong Genetic Variation [607]
CYP19A1 TTSZLWK Strong Biomarker [608]
CYP1A2 TTS1DTU Strong Biomarker [609]
CYP26A1 TTD7Q0R Strong Genetic Variation [610]
CYP2B6 TTMH124 Strong Genetic Variation [611]
CYP2C9 TTR40YJ Strong Genetic Variation [366]
CYP2J2 TTNE1C7 Strong Genetic Variation [612]
DAO TT7Y3EJ Strong Biomarker [613]
DDIT4 TTVEOY6 Strong Altered Expression [614]
DDR1 TTI1FPZ Strong Biomarker [615]
DEFB4A TTIVY12 Strong Genetic Variation [616]
DEK TT1NMGV Strong Biomarker [617]
DEPTOR TTLYP6D Strong Altered Expression [618]
DGKZ TTSBBXL Strong Genetic Variation [619]
DIO1 TTU3X26 Strong Genetic Variation [620]
DKK1 TTE3RAC Strong Biomarker [621]
DKK2 TTST5KX Strong Genetic Variation [622]
DLG4 TT9PB26 Strong Biomarker [623]
DLL1 TT9CFQD Strong Altered Expression [624]
DNAJB1 TTPXAWS Strong Biomarker [625]
DNASE1 TTYWGOJ Strong Altered Expression [626]
DNM2 TTVRA5G Strong Genetic Variation [627]
DNMT3B TT6VZ78 Strong Biomarker [628]
DPP4 TTDIGC1 Strong Biomarker [629]
DRD1 TTZFYLI Strong Biomarker [630]
DRD3 TT4C8EA Strong Genetic Variation [610]
DRD4 TTE0A2F Strong Posttranslational Modification [631]
DTL TT8396I Strong Biomarker [632]
DUSP1 TTG8HIM Strong Biomarker [633]
DYRK1A TTSBVFO Strong Biomarker [634]
DYSF TTA7MXQ Strong Genetic Variation [635]
EEF2K TT1QFLA Strong Biomarker [636]
EHMT1 TTOFXD7 Strong Biomarker [637]
EHMT2 TTS6RZT Strong Altered Expression [638]
EIF2AK2 TTXEZJ4 Strong Biomarker [639]
EIF2AK3 TT79U1M Strong Biomarker [640]
EIF2AK4 TT9U4EP Strong Biomarker [641]
EIF4E TTZGCP6 Strong Biomarker [642]
ELANE TTPLTSQ Strong Altered Expression [643]
ENPEP TT9PBIL Strong Biomarker [644]
ENPP2 TTSCIM2 Strong Biomarker [645]
EPHA4 TTG84D3 Strong Biomarker [646]
EPHA8 TTHZ2LW Strong Biomarker [647]
EPHB2 TTKPV6O Strong Biomarker [648]
EPHX2 TT7WVHI Strong Genetic Variation [494]
EPOR TTAUX24 Strong Altered Expression [649]
ERBB4 TTWALCO Strong Biomarker [650]
ESRRA TTPNQAC Strong Biomarker [651]
F11 TTDM4ZU Strong Biomarker [652]
F11R TT3C8EG Strong Biomarker [653]
F12 TTRJSMV Strong Biomarker [654]
F13A1 TTXI2RA Strong Biomarker [655]
F13B TTAXGIP Strong Biomarker [656]
F2 TT6L509 Strong Genetic Variation [657]
F2R TTL935N Strong Biomarker [658]
F2RL1 TTQR74A Strong Biomarker [659]
F2RL2 TTVSEBF Strong Biomarker [660]
F2RL3 TTD0652 Strong Altered Expression [661]
FABP3 TT3TGLR Strong Altered Expression [662]
FABP5 TTNT2S6 Strong Altered Expression [663]
FAF1 TTSKL3G Strong Altered Expression [664]
FAT1 TTGUJYV Strong Biomarker [665]
FCGR1A TTZK4I3 Strong Biomarker [534]
FCGR3A TTIFOC0 Strong Biomarker [534]
FDPS TTIKWV4 Strong Genetic Variation [666]
FES TTLBY21 Strong Biomarker [667]
FFAR1 TTB8FUC Strong Biomarker [668]
FGF10 TTNPEFX Strong Genetic Variation [561]
FGF14 TTKJX1V Strong Altered Expression [669]
FGF21 TTQ916P Strong Biomarker [670]
FGFR4 TT1KX2S Strong Biomarker [647]
FKBP1A TTMW94E Strong Biomarker [671]
FLT4 TTDCBX5 Strong Biomarker [672]
FOLH1 TT9G4N0 Strong Biomarker [673]
FOLR1 TTVC37M Strong Altered Expression [674]
FOLR2 TTT54CI Strong Altered Expression [674]
FOXQ1 TTEJZOL Strong Altered Expression [675]
FPR2 TTOJ1NF Strong Biomarker [543]
FSHR TTZFDBT Strong Genetic Variation [676]
FTH1 TT975ZT Strong Biomarker [677]
FTO TTFW3BT Strong Biomarker [678]
FYN TT2B9KF Strong Biomarker [679]
G3BP1 TTG0R8Z Strong Genetic Variation [561]
GABRA2 TTBMV1G Strong Genetic Variation [561]
GABRG3 TTEX6LM Strong Genetic Variation [515]
GAD1 TTKGEP3 Strong Altered Expression [680]
GAD2 TT7UY6K Strong Biomarker [681]
GAL TTXZAJ5 Strong Biomarker [682]
GALNS TTT9YPO Strong Biomarker [683]
GART TTEXB9Z Strong Altered Expression [684]
GAS6 TT69QD2 Strong Biomarker [685]
GBA TT1B5PU Strong Genetic Variation [686]
GCG TT6Y4PN Strong Biomarker [637]
GDNF TTF23ML Strong Altered Expression [687]
GGT1 TTZVT7O Strong Genetic Variation [688]
GHR TTHJWYD Strong Biomarker [689]
GHSR TTWDC17 Strong Biomarker [690]
GIP TT40HS5 Strong Biomarker [691]
GJB6 TTAU8SJ Strong Biomarker [692]
GLB1 TTNGJPH Strong Biomarker [693]
GLP1R TTVIMDE Strong Biomarker [637]
GLUL TTURQ2G Strong Genetic Variation [582]
GNAI1 TTL1HWR Strong Altered Expression [448]
GPBAR1 TTSDVTR Strong Altered Expression [694]
GPER1 TTDSB34 Strong Altered Expression [695]
GPI TT19JIZ Strong Genetic Variation [696]
GPNMB TT7315J Strong Biomarker [697]
GPR17 TTMPART Strong Biomarker [698]
GPR20 TT26C7Z Strong Genetic Variation [699]
GPR3 TTHZVSK Strong Altered Expression [700]
GPR39 TTTPCNU Strong Biomarker [701]
GPR6 TTSDWS5 Strong Biomarker [702]
GPX1 TTYAHBP Strong Genetic Variation [703]
GRB2 TTEYRJ9 Strong Biomarker [704]
GRIA1 TTVPQTF Strong Biomarker [705]
GRIA2 TTWM461 Strong Biomarker [706]
GRIA4 TTPJR0G Strong Biomarker [707]
GRIK4 TTQV6BO Strong Biomarker [708]
GRIN1 TTLD29N Strong Biomarker [709]
GRM1 TTVBPDM Strong Biomarker [710]
GRM2 TTXJ47W Strong Altered Expression [711]
GRM3 TT8A9EF Strong Altered Expression [712]
GRM5 TTHS256 Strong Biomarker [713]
GSK3A TTQWAU1 Strong Biomarker [714]
GSR TTEP6RV Strong Altered Expression [715]
GUSB TTHS7CM Strong Altered Expression [716]
GZMB TTKEPHX Strong Altered Expression [530]
HAMP TTRV5YJ Strong Biomarker [717]
HCAR1 TTVK4ZO Strong Biomarker [718]
HCAR2 TTWNV8U Strong Biomarker [718]
HCK TT42OGM Strong Biomarker [719]
HCN1 TTNB6UQ Strong Biomarker [720]
HCRT TTU5HJP Strong Altered Expression [721]
HCRTR2 TT9N02I Strong Genetic Variation [722]
HDAC1 TT6R7JZ Strong Altered Expression [723]
HDAC3 TT4YWTO Strong Biomarker [724]
HDAC4 TTTQGH8 Strong Biomarker [724]
HDAC6 TT5ZKDI Strong Biomarker [725]
HDAC9 TT8M4E1 Strong Biomarker [726]
HDC TTV9GOF Strong Altered Expression [727]
HHAT TT1VNCG Strong Biomarker [728]
HMBS TTT0HW3 Strong Altered Expression [729]
HMGB2 TTA78JQ Strong Biomarker [730]
HMGCS2 TTS0EZJ Strong Biomarker [731]
HNRNPA1 TTPJ9XK Strong Genetic Variation [732]
HNRNPA2B1 TT8UPW6 Strong Biomarker [733]
HPGDS TTCYE56 Strong Genetic Variation [734]
HPSE TTR7GJO Strong Biomarker [735]
HRC TTR4FKD Strong Genetic Variation [736]
HRH3 TT9JNIC Strong Biomarker [737]
HSD11B1 TTN7BL9 Strong Biomarker [738]
HSD17B1 TTIWB6L Strong Biomarker [739]
HSD17B13 TTDJYZR Strong Biomarker [740]
HSD17B4 TTL1WGS Strong Biomarker [741]
HSP90AA1 TT78R5H Strong Biomarker [742]
HSP90AB1 TTH5YN2 Strong Altered Expression [743]
HSPA5 TTW26OG Strong Altered Expression [744]
HSPA8 TTMQL3K Strong Biomarker [745]
HSPB1 TT9AZWY Strong Biomarker [746]
HSPB8 TTY0OJN Strong Biomarker [747]
HSPD1 TT9HL5R Strong Biomarker [748]
HTR1A TTSQIFT Strong Altered Expression [749]
HTR1B TTK8CXU Strong Altered Expression [750]
HTR2C TTWJBZ5 Strong Biomarker [751]
HTR4 TT07C3Y Strong Biomarker [752]
HTR7 TTO9X1H Strong Biomarker [753]
HTT TTIWZ0O Strong Biomarker [754]
IAPP TTHN8EM Strong Biomarker [755]
IDO1 TTZJYKH Strong Biomarker [756]
IFNAR1 TTSYFMA Strong Biomarker [757]
IFNL3 TTRF4Q2 Strong Genetic Variation [758]
IGF1R TTQFBMY Strong Altered Expression [383]
IGF2 TTE8WGO Strong Biomarker [759]
IGFBP1 TTCJTWF Strong Altered Expression [760]
IGFBP2 TTU4QSN Strong Altered Expression [761]
IGFBP5 TTDWEA8 Strong Biomarker [762]
IGFBP7 TTUQ01B Strong Biomarker [763]
IKBKB TTJ3E9X Strong Biomarker [764]
IL12A TTRTK6Y Strong Biomarker [467]
IL16 TTW4R0B Strong Altered Expression [534]
IL17A TTG0MT6 Strong Biomarker [765]
IL19 TT87RWS Strong Genetic Variation [766]
IL1R1 TTWOTEA Strong Genetic Variation [767]
IL1RAP TTWS50K Strong Biomarker [768]
IL1RL1 TT4GZA4 Strong Biomarker [769]
IL23A TTC1GLB Strong Biomarker [765]
IL2RB TT9721Y Strong Altered Expression [770]
IL31 TT1RJXK Strong Altered Expression [771]
IL31RA TT9HPX0 Strong Altered Expression [772]
IL4 TTLGTKB Strong Biomarker [773]
IL4R TTDWHC3 Strong Biomarker [534]
IL5 TTPREZD Strong Altered Expression [534]
IL9 TT0JTFD Strong Biomarker [774]
ILK TT7ALZG Strong Biomarker [775]
INS TTZOPHG Strong Biomarker [543]
INSR TTCBFJO Strong Biomarker [776]
IRAK1 TTXAJWN Strong Biomarker [777]
IRAK4 TTILUKB Strong Genetic Variation [778]
IRF3 TTYR7OH Strong Altered Expression [779]
IRF8 TTHUBNK Strong Biomarker [780]
IRS1 TTAJSQ0 Strong Posttranslational Modification [781]
IRS2 TTF95B8 Strong Biomarker [781]
ITGAL TT48WR6 Strong Biomarker [782]
ITGAV TTT1R2L Strong Biomarker [783]
ITGB3 TTJA1ZO Strong Genetic Variation [784]
ITPR1 TT5HWAT Strong Biomarker [785]
ITPR2 TTK9OV3 Strong Altered Expression [786]
JAG2 TTOJY1B Strong Biomarker [787]
JUN TTS7IR5 Strong Biomarker [788]
KCNB1 TT5OEKU Strong Biomarker [789]
KCNC4 TTODZF1 Strong Altered Expression [790]
KCNMA1 TTE87WJ Strong Biomarker [791]
KCNN2 TT2T5M0 Strong Genetic Variation [561]
KDM1B TT8VP2T Strong Genetic Variation [561]
KDM4A TTZHPB8 Strong Biomarker [792]
KIF11 TTBGTCW Strong Genetic Variation [793]
KIF5A TTCJPAH Strong Altered Expression [794]
KIR2DL2 TTU0P73 Strong Altered Expression [795]
KLK3 TTS78AZ Strong Biomarker [796]
KLK4 TT4319X Strong Biomarker [797]
KLK7 TTE6GTB Strong Biomarker [798]
KLKB1 TTN0PCX Strong Biomarker [799]
KLRC1 TTC4IMS Strong Biomarker [530]
KMO TTIY56R Strong Biomarker [800]
KNG1 TTDJ4MY Strong Biomarker [801]
L1CAM TTC9D3K Strong Biomarker [653]
LAMP1 TTC214J Strong Biomarker [802]
LANCL1 TTZW8NS Strong Biomarker [803]
LBP TTVQJLY Strong Altered Expression [804]
LCAT TTGZ91P Strong Biomarker [805]
LCK TT860QF Strong Biomarker [806]
LCT TTA0OSE Strong Genetic Variation [807]
LGMN TTPTWV5 Strong Altered Expression [808]
LHCGR TT2O4W9 Strong Biomarker [809]
LIF TTGZ5WN Strong Biomarker [810]
LIFR TTID542 Strong Altered Expression [811]
LILRB1 TTC0QRJ Strong Altered Expression [812]
LILRB2 TTHC6XU Strong Biomarker [813]
LIN28A TTO50LN Strong Genetic Variation [408]
LINGO1 TTZYQ80 Strong Biomarker [814]
LIPA TTS8T1M Strong Biomarker [815]
LIPG TTHSZXO Strong Genetic Variation [816]
LNPEP TTY2KP7 Strong Biomarker [817]
LPA TTU9LGY Strong Biomarker [818]
LPAR2 TTB7Y8I Strong Biomarker [440]
LRP6 TTSXOWE Strong Genetic Variation [819]
LTB TTHQ6US Strong Biomarker [508]
LTC4S TTW7OTG Strong Biomarker [820]
LTF TTSZDQU Strong Biomarker [821]
LYN TT1RWNJ Strong Altered Expression [822]
LYZ TTAOZBW Strong Altered Expression [823]
MAG TT9XFON Strong Biomarker [824]
MANF TT56RYE Strong Biomarker [825]
MAOA TT3WG5C Strong Genetic Variation [826]
MAP2K2 TT8H9GB Strong Biomarker [827]
MAP3K10 TT9FN4J Strong Biomarker [828]
MAP3K5 TTOQCD8 Strong Biomarker [829]
MAPK10 TT056SO Strong Biomarker [830]
MAPK14 TTQBR95 Strong Biomarker [458]
MAPK7 TTU6FSC Strong Biomarker [831]
MAPK8 TT0K6EO Strong Biomarker [668]
MAPK9 TT3IVG2 Strong Biomarker [832]
MAPKAP1 TTWDKCL Strong Biomarker [833]
MAPKAPK2 TTMUG9D Strong Biomarker [834]
MAPKAPK5 TT3UJ7Z Strong Biomarker [835]
MARCKS TTHRM39 Strong Biomarker [836]
MARK3 TT3DCYJ Strong Biomarker [837]
MAS1 TTOISYB Strong Biomarker [838]
MAT2A TTSMPXQ Strong Altered Expression [839]
MAZ TT059DA Strong Biomarker [840]
MBOAT4 TTSYOWR Strong Biomarker [841]
MBP TT2RY5P Strong Biomarker [842]
MBTPS1 TTNSM2I Strong Altered Expression [843]
MC1R TT0MV2T Strong Genetic Variation [844]
MCOLN1 TT9XBVO Strong Biomarker [845]
MELTF TT8OBT3 Strong Biomarker [846]
METAP2 TTZL0OI Strong Biomarker [357]
MFGE8 TT1GLAJ Strong Biomarker [847]
MGAM TTXWASR Strong Biomarker [848]
MGLL TTZ963I Strong Biomarker [849]
MMP14 TTJ4QE7 Strong Biomarker [850]
MMP8 TTGA1IV Strong Biomarker [851]
MOBP TTYUK4F Strong Genetic Variation [515]
MOG TTQAFX5 Strong Genetic Variation [852]
MPO TTVCZPI Strong Biomarker [853]
MSH2 TTCAWRT Strong Genetic Variation [561]
MSI1 TTSM4BA Strong Altered Expression [854]
MSI2 TTTXQF6 Strong Altered Expression [854]
MSR1 TT2TDH9 Strong Altered Expression [387]
MSRB1 TT1QUZV Strong Altered Expression [855]
MSTN TTM8I2X Strong Biomarker [856]
MTNR1A TT0WAIE Strong Biomarker [857]
MTNR1B TT32JK8 Strong Altered Expression [858]
MUTYH TTNB0ZK Strong Biomarker [859]
MYD88 TTB6Q2O Strong Biomarker [860]
NAAA TTMN4HY Strong Altered Expression [861]
NACC1 TT4AQ5F Strong Biomarker [862]
NCF1 TTZ4JC3 Strong Genetic Variation [863]
NCL TTK1V5Q Strong Biomarker [864]
NEDD4 TT1QU6G Strong Altered Expression [865]
NEDD9 TT1UREA Strong Genetic Variation [866]
NES TTHZ752 Strong Biomarker [867]
NFKB2 TTKLNRV Strong Biomarker [868]
NLRP3 TT4EN8X Strong Altered Expression [869]
NOTCH3 TTVX7IA Strong Biomarker [870]
NOTCH4 TTXDIK2 Strong Genetic Variation [871]
NPEPPS TT371QC Strong Biomarker [872]
NPM1 TTHBS98 Strong Biomarker [864]
NQO2 TTJLP0R Strong Altered Expression [873]
NR1H3 TTECBXN Strong Genetic Variation [874]
NR3C1 TTOZRK6 Strong Biomarker [370]
NR4A3 TTJQB49 Strong Genetic Variation [875]
NRN1 TTS05MJ Strong Altered Expression [876]
NTF4 TTIM2WO Strong Biomarker [877]
NTN1 TT0AH4L Strong Biomarker [878]
OAT TTTSCQ2 Strong Altered Expression [879]
ODC1 TTUMGNO Strong Biomarker [880]
OPRD1 TT27RFC Strong Genetic Variation [881]
OPRK1 TTQW87Y Strong Biomarker [882]
OSCAR TT71Q5Y Strong Genetic Variation [883]
OSM TTIVXSE Strong Altered Expression [884]
OTC TT5KIO9 Strong Biomarker [885]
P2RX1 TTJW7B3 Strong Genetic Variation [886]
P2RX3 TT2THBD Strong Genetic Variation [886]
P2RX4 TT1NLOA Strong Genetic Variation [886]
P2RY1 TTA93TL Strong Biomarker [887]
P2RY2 TTOZHQC Strong Biomarker [888]
P2RY4 TT24DGP Strong Altered Expression [889]
P2RY6 TTNVSKA Strong Altered Expression [889]
PADI4 TTQHAXM Strong Genetic Variation [890]
PAK1 TTFN95D Strong Genetic Variation [891]
PAWR TT3I4WV Strong Altered Expression [661]
PCSK1 TTED9LZ Strong Biomarker [892]
PCSK9 TTNIZ2B Strong Genetic Variation [893]
PCYT1B TTUAIKM Strong Biomarker [894]
PDCD1LG2 TTW14O3 Strong Genetic Variation [561]
PDE10A TTJW4LU Strong Biomarker [895]
PDE2A TTJGW1Z Strong Biomarker [896]
PDE4D TTSKMI8 Strong Biomarker [897]
PDE5A TTJ0IQB Strong Genetic Variation [898]
PDE7A TT1BC3A Strong Biomarker [899]
PDE7B TTWIEY9 Strong Genetic Variation [515]
PDE9A TTZOEBC Strong Biomarker [900]
PDF TT9SL3Q Strong Biomarker [901]
PDGFB TTQA6SX Strong Genetic Variation [902]
PDGFRB TTI7421 Strong Biomarker [903]
PDK1 TTCZOF2 Strong Biomarker [904]
PEBP1 TT1BGU8 Strong Biomarker [905]
PEMT TT735V2 Strong Genetic Variation [906]
PFKFB3 TTTHMQJ Strong Biomarker [907]
PGD TTZ3IFB Strong Biomarker [908]
PGRMC1 TTY3LAZ Strong Biomarker [909]
PHB TT6U071 Strong Biomarker [904]
PI4KA TTCUS9F Strong Biomarker [910]
PIKFYVE TTA4M1N Strong Biomarker [911]
PKM TT4LOT8 Strong Biomarker [912]
PLA2G1B TT9V5JH Strong Biomarker [913]
PLAU TTGY7WI Strong Genetic Variation [914]
PLAUR TTNOSTX Strong Altered Expression [915]
PLD1 TT3T17P Strong Biomarker [916]
PLD2 TTRLMKF Strong Biomarker [917]
PLK2 TT976FS Strong Biomarker [918]
PLTP TTZF6SN Strong Biomarker [919]
PMEL TT8MK59 Strong Biomarker [868]
PNMT TT0NZIC Strong Altered Expression [920]
PNP TTMCF1Y Strong Biomarker [921]
POLB TTA0XPV Strong Biomarker [922]
POR TTOQ9GZ Strong Biomarker [923]
PPARA TTJ584C Strong Biomarker [924]
PPARGC1B TTKSQ3W Strong Altered Expression [925]
PPIA TTL2ADK Strong Altered Expression [926]
PPIB TT6ZFQ4 Strong Biomarker [927]
PPME1 TTXQ54R Strong Biomarker [928]
PPP1CA TTFLH0E Strong Biomarker [929]
PPP2CA TTHTKNY Strong Biomarker [930]
PPP3CA TTA4LDE Strong Genetic Variation [931]
PPT1 TTSQC14 Strong Biomarker [932]
PPY TTIB95A Strong Biomarker [933]
PRDX4 TTPBL9I Strong Biomarker [934]
PRKACA TT5U49F Strong Altered Expression [935]
PRKCA TTFJ8Q1 Strong Genetic Variation [619]
PRKCB TTYPXQF Strong Biomarker [936]
PRKCD TT7A1BO Strong Biomarker [937]
PRKCE TT57MT2 Strong Altered Expression [938]
PRMT5 TTR1D7X Strong Biomarker [939]
PROC TTZUXYS Strong Biomarker [940]
PSCA TT9T4AV Strong Biomarker [941]
PSIP1 TTH9LDP Strong Altered Expression [770]
PSMB6 TT8EPLT Strong Biomarker [942]
PSMB9 TTOUSTQ Strong Biomarker [943]
PTBP1 TTWMX0U Strong Biomarker [763]
PTGDR TTNVEIR Strong Altered Expression [944]
PTGER1 TTG1QMU Strong Biomarker [945]
PTGER2 TT1ZAVI Strong Biomarker [946]
PTGER3 TTPNGDE Strong Biomarker [947]
PTGES2 TTWU04I Strong Altered Expression [948]
PTK2B TTTEFBV Strong Biomarker [949]
PTN TTA9EJK Strong Biomarker [950]
PTPN1 TTELIN2 Strong Biomarker [951]
PTPN13 TT405FP Strong Biomarker [952]
PYY TTVFJLX Strong Biomarker [953]
RAB7A TTF6WAQ Strong Biomarker [954]
RAC1 TT2M9CG Strong Biomarker [955]
RACK1 TTJ10AL Strong Altered Expression [956]
RASA1 TTPNZ1F Strong Biomarker [957]
REG3A TTL4H8N Strong Biomarker [958]
RENBP TTZCG0Q Strong Biomarker [959]
RGS2 TTKB7T3 Strong Altered Expression [960]
RGS4 TTGTKX9 Strong Biomarker [961]
RGS6 TTJ96M8 Strong Biomarker [957]
RHD TTLCKI8 Strong Genetic Variation [962]
RHO TTH0KSX Strong Biomarker [963]
RIPK1 TTVJHX8 Strong Posttranslational Modification [211]
RNMT TTG45HY Strong Biomarker [964]
ROCK1 TTZN7RP Strong Biomarker [965]
ROCK2 TTGWKQJ Strong Biomarker [965]
RORA TT1TYN7 Strong Biomarker [736]
ROS1 TTSZ6Y3 Strong Biomarker [966]
RPL15 TTQRVC9 Strong Altered Expression [788]
RPS6KB1 TTG0U4H Strong Biomarker [967]
RPS6KB2 TTMVQXO Strong Genetic Variation [968]
RTN4 TT7GXMU Strong Biomarker [969]
RTN4R TTVRZUO Strong Biomarker [970]
RXRA TT6PEUO Strong Biomarker [436]
S100A12 TTQ4ESF Strong Biomarker [971]
S100A6 TT716MY Strong Altered Expression [972]
S100B TTQ0V86 Strong Biomarker [973]
SAA1 TTY0DN9 Strong Biomarker [974]
SCARB1 TTRE324 Strong Genetic Variation [816]
SCD TT6RIOV Strong Biomarker [975]
SCG3 TTY5R9H Strong Biomarker [976]
SCN1A TTANOZH Strong Biomarker [862]
SDC2 TT5H2F0 Strong Genetic Variation [977]
SEMA3A TTVKD3S Strong Biomarker [978]
SEMA4D TT5UT28 Strong Biomarker [978]
SERPINA1 TTA7UJC Strong Biomarker [979]
SERPINC1 TT4QPUL Strong Biomarker [980]
SERPINF1 TTR59S1 Strong Altered Expression [981]
SERPING1 TTVQ6R9 Strong Biomarker [982]
SETD7 TTJ0FSU Strong Genetic Variation [561]
SGCA TTS9Q5V Strong Biomarker [983]
SGCG TTSMT9W Strong Biomarker [984]
SGK1 TTTV8EJ Strong Biomarker [985]
SGO1 TTBPKGD Strong Genetic Variation [986]
SGSH TTPJ2SH Strong Biomarker [987]
SIGMAR1 TT5TPI6 Strong Biomarker [988]
SIRT2 TTLKF5M Strong Biomarker [989]
SIRT5 TTH0IOD Strong Altered Expression [990]
SIRT6 TTUXYWF Strong Biomarker [991]
SLC10A2 TTPI1M5 Strong Biomarker [992]
SLC16A3 TTG6VD5 Strong Biomarker [993]
SLC18A3 TTV8KWS Strong Biomarker [994]
SLC19A3 TT9BTWM Strong Genetic Variation [995]
SLC1A1 TTG2A6F Strong Biomarker [996]
SLC1A2 TT2F078 Strong Biomarker [997]
SLC1A3 TT8WRDA Strong Biomarker [998]
SLC22A2 TT0XOJN Strong Biomarker [999]
SLC22A8 TTTQR47 Strong Biomarker [999]
SLC25A4 TTU5A6Q Strong Biomarker [1000]
SLC29A1 TTLXAKE Strong Biomarker [1001]
SLC29A4 TTTR957 Strong Altered Expression [1002]
SLC2A12 TTZO36H Strong Altered Expression [407]
SLC33A1 TTL69WB Strong Biomarker [1003]
SLC40A1 TT6Y1PG Strong Genetic Variation [1004]
SLC44A4 TT0NYDG Strong Biomarker [1005]
SLC47A1 TTMHCGA Strong Altered Expression [1002]
SLC52A2 TT6TKEN Strong Biomarker [658]
SLC5A2 TTF8JAT Strong Biomarker [1006]
SLC6A1 TTPRKM0 Strong Altered Expression [1007]
SLC6A12 TTQBMPI Strong Altered Expression [1007]
SLC6A15 TT4LRUE Strong Biomarker [879]
SLC6A2 TTAWNKZ Strong Altered Expression [1008]
SLC7A11 TTBZMIO Strong Biomarker [1009]
SLC7A5 TTPH2JB Strong Altered Expression [1010]
SLC8A1 TTCF82X Strong Genetic Variation [1011]
SLIT2 TTDWK85 Strong Altered Expression [1012]
SMAD1 TT9GR53 Strong Altered Expression [1013]
SMPD1 TTJTM88 Strong Biomarker [1014]
SMPD2 TTE5VI6 Strong Biomarker [1015]
SNAP25 TTYQWA0 Strong Genetic Variation [1016]
SNCG TT5TQNZ Strong Altered Expression [1017]
SORT1 TTRX9AV Strong Biomarker [1018]
SPHK1 TTOHFIY Strong Biomarker [1019]
SPHK2 TTCN0M9 Strong Biomarker [1020]
SQLE TTE14XG Strong Biomarker [1021]
SRPK2 TTCZEJ9 Strong Altered Expression [1022]
SRR TTZFUY6 Strong Altered Expression [1023]
SST TTWF7UG Strong Biomarker [1024]
SSTR2 TTZ6T9E Strong Biomarker [1025]
SSTR3 TTJX3UE Strong Genetic Variation [1026]
SSTR4 TTAE1BR Strong Biomarker [440]
ST14 TTPRO7W Strong Altered Expression [1027]
STAB1 TTJFEOC Strong Biomarker [1028]
STC1 TTDLUER Strong Biomarker [1029]
STK16 TTFGN19 Strong Biomarker [1030]
STK32B TT4D2GZ Strong Genetic Variation [515]
STMN1 TT7W5OT Strong Altered Expression [1031]
STS TTHM0R1 Strong Biomarker [1032]
SYVN1 TT8XKYM Strong Biomarker [1033]
TACR2 TTYO0A3 Strong Biomarker [1034]
TBK1 TTMP03S Strong Genetic Variation [1035]
TBX21 TTNF9PH Strong Genetic Variation [1036]
TCF3 TTULOD8 Strong Altered Expression [770]
TCF7L2 TT80QAL Strong Genetic Variation [816]
TCIRG1 TTVRN05 Strong Altered Expression [1037]
TDO2 TTXNCBV Strong Altered Expression [1038]
TDP1 TT64IHJ Strong Genetic Variation [1039]
TDP2 TTYF26D Strong Genetic Variation [1039]
TERF1 TT1Y6J2 Strong Biomarker [1040]
TERF2 TT5XSLT Strong Biomarker [1040]
TF TT8WXAV Strong Genetic Variation [1041]
TFF1 TTNOJIZ Strong Genetic Variation [1042]
TFRC TT8MG4S Strong Biomarker [1043]
TGFB2 TTI0KH6 Strong Biomarker [1044]
TGFB3 TTWOMY8 Strong Biomarker [1045]
TGFBR1 TTP4520 Strong Altered Expression [1046]
TGM1 TT7A949 Strong Biomarker [656]
TGM2 TT2F4OL Strong Altered Expression [1047]
TLR2 TTY7ZHS Strong Biomarker [1048]
TLR5 TTCXP8J Strong Altered Expression [685]
TLR6 TTWRI8V Strong Biomarker [1049]
TLR9 TTSHG0T Strong Biomarker [530]
TMEM97 TT9NXW4 Strong Biomarker [1050]
TMPRSS6 TTL9KE7 Strong Altered Expression [858]
TNFRSF1A TTG043C Strong Biomarker [1051]
TNFRSF1B TT63WSF Strong Biomarker [1052]
TNFRSF21 TT8UA0T Strong Biomarker [1053]
TNK1 TTWS7I3 Strong Genetic Variation [1054]
TNNI3 TTNLDK6 Strong Biomarker [1055]
TP53BP1 TTX4UE9 Strong Biomarker [1056]
TPH1 TTZSJHV Strong Genetic Variation [1057]
TPH2 TT3KLDP Strong Biomarker [1058]
TPP1 TTOVYPT Strong Biomarker [1059]
TPT1 TT3PTB6 Strong Biomarker [1060]
TPX2 TT0PHL4 Strong Biomarker [868]
TREM1 TTHZQP0 Strong Biomarker [1061]
TRH TT2Z39D Strong Biomarker [801]
TRIM27 TTTO3QN Strong Biomarker [543]
TRPA1 TTELV3W Strong Altered Expression [1062]
TRPC1 TTA76X0 Strong Altered Expression [1063]
TRPM1 TTTDAI9 Strong Genetic Variation [561]
TRPM2 TTEBMN7 Strong Biomarker [1064]
TRPM7 TTFPVZO Strong Biomarker [1065]
TSG101 TTHU7JA Strong Biomarker [1066]
TSPAN7 TTMT6VE Strong Biomarker [1067]
TTBK1 TTYFAM9 Strong Altered Expression [1068]
TXN TTZJ5U9 Strong Biomarker [1069]
TXNIP TTTLDZK Strong Biomarker [1070]
TXNRD1 TTR7UJ3 Strong Biomarker [1071]
TYR TTULVH8 Strong Genetic Variation [1072]
TYRO3 TTIEMFN Strong Biomarker [685]
TYRP1 TTFRV98 Strong Genetic Variation [1073]
UBC TTBP3XA Strong Altered Expression [788]
UBE3A TTUZX6V Strong Biomarker [1074]
UGCG TTPHEX3 Strong Biomarker [1075]
USP10 TT5IH09 Strong Biomarker [1076]
USP13 TTVJIO2 Strong Altered Expression [1077]
USP14 TTVSYP9 Strong Biomarker [1078]
USP2 TTUEQ1W Strong Posttranslational Modification [1079]
UTRN TTNO1VA Strong Biomarker [1080]
VDR TTK59TV Strong Genetic Variation [1081]
WAS TTE8T73 Strong Biomarker [1082]
WEE1 TTJFOAL Strong Genetic Variation [1083]
WNK1 TTJ9UMX Strong Biomarker [1084]
YES1 TT0SQ8J Strong Altered Expression [723]
ZAP70 TTUMHT8 Strong Biomarker [1085]
ZNF217 TTY3BRA Strong Biomarker [1086]
ZNF224 TT1CDXL Strong Genetic Variation [1087]
COL18A1 TT63DI9 Definitive Genetic Variation [561]
GDF2 TTAP4T1 Definitive Biomarker [1088]
NR4A2 TT9HKN3 Definitive Altered Expression [1089]
NTF3 TTZHKV9 Definitive Biomarker [1090]
PLA2G7 TTDNFMT Definitive Biomarker [1091]
------------------------------------------------------------------------------------
⏷ Show the Full List of 854 DTT(s)
This Disease Is Related to 34 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC30A4 DT280XI Limited Biomarker [1092]
SLC32A1 DTXQYLR Limited Biomarker [1093]
SLC30A6 DTKPRIL moderate Biomarker [1094]
ABCA2 DTJ4NEG Strong Genetic Variation [1095]
ABCA8 DT9NXMV Strong Genetic Variation [561]
ABCD1 DTKM9DZ Strong Biomarker [1096]
ATP12A DT5NLZA Strong Biomarker [488]
ATP7A DT0LT17 Strong Genetic Variation [1097]
SLC11A1 DT650XW Strong Biomarker [1098]
SLC16A7 DTLT3UG Strong Biomarker [1099]
SLC18A1 DTM953D Strong Genetic Variation [1100]
SLC22A17 DTXI9E6 Strong Biomarker [1101]
SLC22A5 DT3HUVD Strong Biomarker [1002]
SLC24A2 DTKRWE8 Strong Altered Expression [1102]
SLC24A3 DTO18LP Strong Biomarker [1103]
SLC25A20 DTQOUM4 Strong Biomarker [1104]
SLC25A27 DT0HW5C Strong Altered Expression [1105]
SLC25A37 DTLBGTZ Strong Biomarker [1106]
SLC25A38 DTV8SWX Strong Biomarker [1107]
SLC26A7 DTOTME4 Strong Altered Expression [1108]
SLC2A14 DT18YD9 Strong Genetic Variation [1109]
SLC2A3 DT9SQ3L Strong Genetic Variation [1110]
SLC2A8 DT2I7BM Strong Biomarker [1111]
SLC30A1 DT1BO38 Strong Altered Expression [1112]
SLC30A10 DTYBI73 Strong Biomarker [1113]
SLC31A1 DTP8L4F Strong Biomarker [1114]
SLC35A1 DTVZIRG Strong Biomarker [1115]
SLC35A2 DT0567K Strong Genetic Variation [1116]
SLC38A10 DT2LGOY Strong Biomarker [1117]
SLC4A8 DTW40Z7 Strong Genetic Variation [515]
SLC7A9 DTP7AEQ Strong Biomarker [1118]
SLC8A3 DTYFRQT Strong Genetic Variation [995]
SLC9A6 DTN0JXW Strong Altered Expression [1119]
SLC24A4 DTQWF14 Definitive Genetic Variation [378]
------------------------------------------------------------------------------------
⏷ Show the Full List of 34 DTP(s)
This Disease Is Related to 58 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
HSD17B7 DEDMWFX Limited Biomarker [740]
NAT10 DEZV4AP Disputed Biomarker [417]
CYP27A1 DEBS639 moderate Altered Expression [1120]
ACP3 DEDW5H6 Strong Altered Expression [1121]
ACSS2 DEE76VW Strong Biomarker [1122]
ADH1B DEEN9RD Strong Altered Expression [1123]
ADH6 DE017IC Strong Altered Expression [1124]
AKR1A1 DED2FW3 Strong Biomarker [1125]
AKR1C2 DEOY5ZM Strong Biomarker [739]
ALDH1A2 DEKN1H4 Strong Genetic Variation [816]
AOC2 DE8DP90 Strong Biomarker [469]
APRT DE2MV1R Strong Biomarker [1126]
CES2 DETHCPD Strong Biomarker [1127]
COLGALT2 DE8RIZD Strong Genetic Variation [433]
CRMP1 DE0EUXB Strong Biomarker [1080]
CYP7B1 DE36TMY Strong Biomarker [1128]
CYP8B1 DETL4WB Strong Genetic Variation [1129]
DDAH1 DEY0TQC Strong Altered Expression [1130]
DDO DE8PQ7T Strong Altered Expression [1131]
FAAH DEUM1EX Strong Biomarker [1132]
GLS DE3E0VT Strong Altered Expression [1133]
GNPDA2 DEPJGQB Strong Biomarker [1134]
GPT DER5HFI Strong Altered Expression [1135]
GSTZ1 DEQPEMB Strong Biomarker [1136]
HAGH DE05IKP Strong Biomarker [1137]
HK1 DEDMAGE Strong Biomarker [1138]
HSD17B10 DEGSPC9 Strong Altered Expression [1139]
MARS1 DE0K52I Strong Genetic Variation [1140]
MAT1A DEQ6NC9 Strong Altered Expression [1141]
MMEL1 DEYCUQ2 Strong Biomarker [1142]
MSRA DEU2ZBY Strong Altered Expression [1143]
MSRB2 DEMQOF7 Strong Biomarker [1144]
MT2A DEFKGT7 Strong Altered Expression [858]
MTRR DE6NIY9 Strong Genetic Variation [1145]
NAT1 DE7OAB3 Strong Genetic Variation [1146]
NAT2 DER7TA0 Strong Genetic Variation [1147]
NAT8 DEA742Z Strong Biomarker [1148]
NMNAT1 DE4D159 Strong Biomarker [1149]
NMNAT2 DE2HB58 Strong Altered Expression [1150]
PARK7 DEPOVCH Strong Biomarker [1151]
PCK1 DEPLH5Z Strong Genetic Variation [1152]
PCYT1A DEQYXD4 Strong Genetic Variation [1153]
PER1 DE9HF0I Strong Genetic Variation [1154]
PGPEP1 DEVDR46 Strong Biomarker [500]
PMM2 DEBRX3L Strong Biomarker [1155]
PON3 DETXQZ1 Strong Genetic Variation [1156]
PSAT1 DEBS17P Strong Biomarker [872]
PTGDS DER3H9C Strong Biomarker [1157]
SI DE5EO4Y Strong Biomarker [848]
SMOX DEOH5V3 Strong Biomarker [1158]
SULT2A1 DE0P6LK Strong Biomarker [1085]
TGM6 DEUWCVD Strong Genetic Variation [515]
THOP1 DE95LJC Strong Biomarker [1159]
UBASH3B DE10BJ5 Strong Biomarker [1160]
WARS1 DEPVE0M Strong Biomarker [1161]
WARS2 DEPTKBQ Strong Biomarker [1161]
XPNPEP1 DE8E6X9 Strong Biomarker [1162]
FXN DEXVHDB Definitive Genetic Variation [1163]
------------------------------------------------------------------------------------
⏷ Show the Full List of 58 DME(s)
This Disease Is Related to 1411 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ALDH1L1 OT15HOJX Limited Biomarker [1164]
APLP1 OTD176ZS Limited Biomarker [1165]
ATF6 OTAFHAVI Limited Altered Expression [423]
BRAP OTB7BAFQ Limited Biomarker [1166]
C1D OTI9PMN1 Limited Altered Expression [1167]
CALB2 OTSNMCG9 Limited Biomarker [1168]
CDC42 OT5QBC5M Limited Biomarker [1169]
CH25H OT9S2BSW Limited Genetic Variation [1170]
COL25A1 OT7M23Z9 Limited Altered Expression [1171]
COLQ OT4BHUGQ Limited Genetic Variation [1172]
DNAH8 OTGES2OU Limited Biomarker [1173]
ECE2 OTZLNQVL Limited Autosomal dominant [367]
ESCO1 OTZ9P12A Limited Biomarker [1174]
FOXO3 OTHXQG4P Limited Altered Expression [1175]
FZD4 OTGLZIE0 Limited Biomarker [375]
GPR151 OT7EACU6 Limited Biomarker [375]
HLA-DRB5 OTUX5TWM Limited Genetic Variation [1176]
HSPA1A OTKGIE76 Limited Biomarker [625]
IMPA1 OTBUVW1Z Limited Biomarker [1166]
IQCK OT4QNL67 Limited Biomarker [445]
LGR6 OTPZ1PWR Limited Biomarker [375]
MAP1A OTHO8K43 Limited Biomarker [1177]
MARK1 OTP7KL47 Limited Biomarker [1178]
MEFV OTRJ6S6K Limited Biomarker [1179]
MEOX2 OTKZCJCB Limited Genetic Variation [1180]
MRGPRX3 OTRKCCDS Limited Biomarker [375]
MRGPRX4 OTOBHZVA Limited Biomarker [375]
MS4A4A OTWV82RP Limited Genetic Variation [378]
MYO5C OTKLOCWZ Limited Biomarker [1181]
NCSTN OT5QBTA4 Limited Biomarker [1182]
NECTIN2 OTIE0W6O Limited Genetic Variation [816]
NFIA OTDHQ9CG Limited Biomarker [1174]
NFIB OTX94PD0 Limited Biomarker [1174]
NFIC OTLMCUIB Limited Genetic Variation [1183]
NFIX OT1DPZAE Limited Biomarker [1174]
NLRP12 OTGR132Z Limited Biomarker [1184]
OGDHL OT1AZK6R Limited Biomarker [1185]
OLIG2 OTMCN6D3 Limited Biomarker [1186]
PAEP OTQA0NV4 Limited Biomarker [1187]
PDIK1L OTISF4KG Limited Biomarker [1188]
PHF1 OTW2PSIR Limited Biomarker [1189]
PHYHD1 OTTKHTAC Limited Biomarker [1181]
PLA2G6 OT5FL0WU Limited Biomarker [1190]
PLB1 OTZ6TTYV Limited Biomarker [913]
POTEF OTV3WXYE Limited Altered Expression [422]
PRRT2 OTCJUBDO Limited Biomarker [936]
PRUNE2 OTGW2974 Limited Biomarker [1191]
RAB5A OTFR2KM4 Limited Biomarker [1192]
RELN OTLKMW1O Limited Altered Expression [1193]
S100A1 OT1F2G4J Limited Biomarker [1194]
SCARB2 OTN929M8 Limited Altered Expression [1195]
SCFD1 OTN4T7JI Limited Genetic Variation [1196]
SET OTGYYQJO Limited Biomarker [1197]
SGSM3 OTIB1P8A Limited Biomarker [1198]
SORCS1 OTP8PAKU Limited Biomarker [1199]
SUMO1 OTJFD4P5 Limited Biomarker [1200]
TFCP2 OTA246TE Limited Biomarker [1201]
TMED10 OTUXSHH7 Limited Altered Expression [1202]
TMEM230 OTAFALFV Limited Biomarker [1203]
TPI1 OT14KP4B Limited Biomarker [1204]
ATRNL1 OTY5JUX2 Disputed Biomarker [417]
CCL27 OTUZYC61 Disputed Biomarker [417]
PDLIM3 OTVXQC81 Disputed Biomarker [417]
TAX1BP1 OTGJMGJ9 Disputed Genetic Variation [417]
ADAMTS3 OT2U6VF5 moderate Biomarker [1205]
ALPP OTZU4G9W moderate Biomarker [417]
APLP2 OTTFE53M moderate Biomarker [1206]
ASAH1 OT1DNGXL moderate Altered Expression [428]
CASS4 OTGPIPUS moderate Genetic Variation [378]
CELF1 OT6JQ5RS moderate Genetic Variation [1207]
MARK4 OT6Z2TGV moderate Genetic Variation [378]
MFN2 OTPYN8A3 moderate Altered Expression [1208]
MS4A6A OTK4BXQS moderate Genetic Variation [378]
PCDH11X OTLICG18 moderate Genetic Variation [1209]
PRDX6 OTS8KC8A moderate Altered Expression [1210]
SCRN1 OTELM5C2 moderate Biomarker [1211]
SIL1 OTDI85I5 moderate Biomarker [1212]
SLPI OTUNFUU8 moderate Biomarker [417]
SNCB OTELSEK6 moderate Genetic Variation [1213]
SNPH OTL6XBFA moderate Biomarker [1214]
SRA1 OTYOGMTG moderate Altered Expression [1215]
SYNJ1 OTTE02XC moderate Biomarker [1216]
A1CF OTJBKFA1 Strong Biomarker [485]
AATF OT1QOKLD Strong Biomarker [1217]
ABCG4 OT2XJIOG Strong Altered Expression [1218]
ACADVL OT50L4XB Strong Altered Expression [1219]
ACAP1 OTPFQ2QC Strong Biomarker [1220]
ACCS OTHIHI9D Strong Biomarker [1122]
ACKR2 OTWYY14H Strong Genetic Variation [1129]
ACMSD OTPSXPSF Strong Genetic Variation [1221]
ACO1 OT2VUR7L Strong Biomarker [1222]
ACOT7 OT7C68YV Strong Biomarker [361]
ACOT8 OTHY684G Strong Altered Expression [1223]
ACSL6 OT0TT8P8 Strong Genetic Variation [1224]
ACTB OT1MCP2F Strong Altered Expression [422]
ACTBL2 OTD6B81U Strong Biomarker [361]
ACTG2 OTRDWUO0 Strong Biomarker [361]
ADAM12 OTZKOTDB Strong Genetic Variation [1225]
ADAM19 OTH88TXU Strong Biomarker [1226]
ADAMTS10 OTNJ9VSU Strong Biomarker [1227]
ADAMTS2 OTTK22NO Strong Biomarker [1228]
ADAP1 OTM4CHU1 Strong Biomarker [1229]
ADARB1 OTGKSZEV Strong Altered Expression [1230]
ADCY10 OTYSTB0R Strong Biomarker [718]
ADD3 OTDRSHAZ Strong Biomarker [1231]
ADI1 OT8IOD03 Strong Biomarker [1232]
ADIPOR1 OT65ZFZN Strong Biomarker [1233]
ADNP OTEGICWR Strong Genetic Variation [1234]
ADRM1 OTOU4EY6 Strong Biomarker [797]
AEBP1 OTBI1RZ6 Strong Altered Expression [876]
AFF1 OTT2C78E Strong Genetic Variation [515]
AGAP2 OTEYO9TM Strong Biomarker [1235]
AGBL1 OT8NQLH0 Strong Genetic Variation [561]
AGFG2 OTXQZHCR Strong Genetic Variation [494]
AGO1 OTD3R434 Strong Biomarker [1236]
AGPS OTFBFPV4 Strong Genetic Variation [1237]
AGRN OTWJENAZ Strong Altered Expression [1238]
AHCYL1 OTX8L3M5 Strong Genetic Variation [561]
AHI1 OT8K2YWY Strong Biomarker [1239]
AHNAK OT6KH1WG Strong Genetic Variation [561]
AHSA1 OTC7AFHT Strong Biomarker [458]
AIM2 OT86QUI8 Strong Biomarker [1240]
AIMP1 OTTA5C3U Strong Biomarker [1241]
AIRE OTA7G1Y1 Strong Biomarker [1242]
AKAP5 OTE2AGPC Strong Biomarker [1013]
AKAP9 OT7Z2YRP Strong Genetic Variation [1243]
ALDH7A1 OTV57BZD Strong Biomarker [1244]
ALPK2 OTWZZDQ9 Strong Genetic Variation [378]
ALS2 OT8BAM04 Strong Biomarker [1245]
AMFR OTQRX7LC Strong Biomarker [1246]
AMIGO1 OT2EPDFC Strong Genetic Variation [1247]
AMIGO2 OTPAIT1O Strong Genetic Variation [1248]
AMPH OTWPGWZX Strong Genetic Variation [1249]
ANGPT4 OT881M3K Strong Biomarker [644]
ANK3 OTJ3IRBP Strong Biomarker [1250]
ANKK1 OT0OM1O0 Strong Genetic Variation [1251]
ANKRD31 OTBDW2F2 Strong Genetic Variation [1252]
ANKRD55 OT62KZII Strong Genetic Variation [515]
ANKS1B OT26DGM9 Strong Altered Expression [1253]
ANO3 OTM34U6Q Strong Genetic Variation [433]
ANO4 OT8E2PMA Strong Genetic Variation [515]
ANP32A OTRHPFO2 Strong Biomarker [1254]
ANTXR1 OT5W1GPC Strong Genetic Variation [1255]
ANXA6 OT9KIQ0Y Strong Biomarker [1160]
AP2A2 OTD1UGUN Strong Genetic Variation [1256]
AP4M1 OT2BG2Z3 Strong Genetic Variation [494]
APBA1 OTUH9JPD Strong Biomarker [1257]
APBA2 OTXD8ID1 Strong Biomarker [713]
APBA3 OTAAATXF Strong Biomarker [1258]
APBB2 OT1VD51B Strong Biomarker [1259]
APBB3 OTNUTR0N Strong Genetic Variation [1260]
APCDD1 OTV9AD0L Strong Biomarker [1261]
APH1A OT97F1TU Strong Biomarker [1262]
APMAP OT1P2GJA Strong Biomarker [1263]
APOA5 OTEVKLVA Strong Genetic Variation [1170]
APOC1 OTA58CED Strong Genetic Variation [1170]
APOC4 OTE8ZUXY Strong Genetic Variation [494]
APOD OTT77XW8 Strong Biomarker [1264]
APOF OT12S5QS Strong Genetic Variation [1265]
APOM OTI3FQQC Strong Biomarker [1265]
APPL1 OT8VR95S Strong Biomarker [1266]
AQP4 OTA9MYD5 Strong Biomarker [1267]
ARAP2 OTBXYFRH Strong Genetic Variation [433]
ARAP3 OTUWZTH7 Strong Biomarker [1268]
ARC OTN2QQPG Strong Biomarker [1269]
ARHGAP20 OTG1STV8 Strong Genetic Variation [515]
ARHGEF15 OTGHDJFP Strong Altered Expression [1270]
ARHGEF2 OTBQTFRT Strong Altered Expression [1271]
ARHGEF5 OTUVGFT9 Strong Altered Expression [1272]
ARHGEF7 OT9BPJCL Strong Biomarker [1273]
ARID4B OTYLPILE Strong Biomarker [1274]
ARL17B OTXZD3DG Strong Genetic Variation [1252]
ARMCX5-GPRASP2 OT2N7NQR Strong Biomarker [1275]
ARMH1 OTTJC0D6 Strong Biomarker [803]
ARMS2 OTUXHJ9H Strong Genetic Variation [1276]
ARPP19 OTZS3IT6 Strong Biomarker [1277]
ARTN OTWIWGL6 Strong Biomarker [1278]
ARVCF OT78DKOU Strong Genetic Variation [561]
ASCC1 OTH4VAP9 Strong Biomarker [1273]
ASCC2 OT3B204T Strong Biomarker [868]
ASL OTI2NGQR Strong Biomarker [1279]
ASPM OTKXQMNA Strong Biomarker [485]
ASTN2 OTF0W2FJ Strong Genetic Variation [1280]
ATCAY OTSIAM08 Strong Biomarker [1281]
ATF2 OTNIZPEA Strong Altered Expression [1282]
ATF7IP OTU6ZA7F Strong Biomarker [1283]
ATG12 OTJRO09Y Strong Biomarker [1284]
ATG4B OTQ4RNRM Strong Biomarker [1202]
ATG4C OTD9HN3X Strong Genetic Variation [1285]
ATG5 OT4T5SMS Strong Biomarker [1284]
ATP2B4 OTMWFDAC Strong Biomarker [1286]
ATP5F1A OT3FZDLX Strong Biomarker [1287]
ATP5F1B OTLFZUQK Strong Altered Expression [1288]
ATP5MC1 OTOLSYOI Strong Altered Expression [1289]
ATP5MC2 OTA5F480 Strong Altered Expression [1289]
ATP5PD OTAJDLE2 Strong Genetic Variation [1290]
ATP5PF OTDAE8FP Strong Altered Expression [1289]
ATP5PO OTU3MCTN Strong Biomarker [403]
ATP6V0D1 OT9GU2NW Strong Biomarker [1291]
ATP6V0E1 OTZZIUYY Strong Altered Expression [513]
ATP6V1B2 OTNX2V4Z Strong Biomarker [1292]
ATP6V1E1 OT76J5R9 Strong Altered Expression [513]
ATP6V1H OTX17GQ9 Strong Genetic Variation [1293]
ATXN1 OTQF0HNR Strong Biomarker [754]
ATXN7L1 OT5EZO0M Strong Genetic Variation [1294]
AZI2 OT61Q7Q8 Strong Altered Expression [1223]
AZIN2 OT8OB7CG Strong Biomarker [1295]
AZU1 OTHXU264 Strong Genetic Variation [1296]
B3GALT4 OTLKSMQE Strong Biomarker [1297]
B3GAT1 OTXFP98E Strong Altered Expression [1298]
BAG1 OTRQNIA4 Strong Biomarker [1299]
BAG2 OTI6LD27 Strong Biomarker [1299]
BAG3 OTVXYUDQ Strong Biomarker [1300]
BAG5 OT0J97C6 Strong Altered Expression [1301]
BARHL1 OTIUTWBD Strong Biomarker [1090]
BARHL2 OTASKG2P Strong Biomarker [1302]
BCAM OTHZOPSD Strong Genetic Variation [378]
BCAN OTPVY3ZR Strong Biomarker [1303]
BCAP31 OTKSACR4 Strong Biomarker [1304]
BCAR1 OTKT2C2N Strong Biomarker [589]
BCAS3 OTDVAX6B Strong Genetic Variation [515]
BCL2L11 OTNQQWFJ Strong Altered Expression [1305]
BCS1L OT5PY5CY Strong Biomarker [1306]
BHLHE23 OTLSVD17 Strong Biomarker [1307]
BHLHE40 OTITX14U Strong Genetic Variation [1308]
BIN2 OT4S45WJ Strong Biomarker [1309]
BLM OTEJOAJX Strong Biomarker [1310]
BLNK OTSSPF6F Strong Genetic Variation [1311]
BLOC1S3 OTNRFFLW Strong Genetic Variation [378]
BMPER OTBYON4H Strong Genetic Variation [1312]
BMS1 OTEGQ8ZO Strong Biomarker [1313]
BNC1 OTGJ5WUF Strong Biomarker [484]
BNIP3 OT4SO7J4 Strong Genetic Variation [1314]
BPTF OTD1RZAD Strong Biomarker [840]
BRI3 OT1RWIH7 Strong Biomarker [1315]
BTNL2 OTTTEMZA Strong Genetic Variation [1316]
BZW2 OTBT0A1B Strong Genetic Variation [515]
C10orf71 OT5NXMLV Strong Genetic Variation [561]
C1orf52 OT8RQW3W Strong Altered Expression [1317]
C1QA OT6XKVVA Strong Altered Expression [1318]
C1QL1 OTNQ0G3E Strong Biomarker [1319]
C1R OTA0ZNIU Strong Biomarker [1320]
C2 OTHMF4YM Strong Biomarker [1321]
C20orf203 OT3D1FOY Strong Altered Expression [1322]
C9 OT7I5FDX Strong Biomarker [1323]
CACUL1 OT6P1ZVP Strong Altered Expression [1324]
CACYBP OTJMZD2T Strong Biomarker [1134]
CALB1 OTM7IXDG Strong Genetic Variation [1325]
CALCOCO2 OTRGX0OV Strong Biomarker [1326]
CALM2 OTNYA92F Strong Biomarker [1327]
CALML5 OTOFJLFA Strong Biomarker [1328]
CAMK1D OTU24HAU Strong Biomarker [1329]
CAMK2A OTJGX19T Strong Genetic Variation [1330]
CAMK4 OT47RDGV Strong Biomarker [1331]
CAMKMT OTLJBRUW Strong Biomarker [1332]
CAPG OTJ86KI6 Strong Biomarker [1333]
CARD8 OTXXZYWU Strong Genetic Variation [1334]
CASP12 OTY2W6FG Strong Therapeutic [1335]
CAST OTBXZZGF Strong Biomarker [1336]
CASZ1 OTWJ2OR8 Strong Biomarker [1115]
CBFA2T2 OTNOIB23 Strong Biomarker [1337]
CBLC OT3RKZI9 Strong Genetic Variation [378]
CBLIF OTNE20WU Strong Altered Expression [1338]
CBLN4 OTO7QW6Y Strong Biomarker [1339]
CBX5 OT8VYY84 Strong Genetic Variation [1340]
CCDC134 OT70OQQV Strong Genetic Variation [1341]
CCDC83 OTF1ETS6 Strong Genetic Variation [1342]
CCDC89 OT864TCD Strong Genetic Variation [561]
CCHCR1 OT22C116 Strong Genetic Variation [1343]
CCL1 OT23NON8 Strong Biomarker [1344]
CCL19 OTQ2UJMH Strong Biomarker [530]
CCL26 OT2B7HR9 Strong Biomarker [1345]
CCL4 OT6B8P25 Strong Biomarker [1346]
CCL4L2 OTDBSXOU Strong Altered Expression [1347]
CCL8 OTCTWYN8 Strong Genetic Variation [1348]
CCNC OTMVK4K4 Strong Biomarker [1349]
CCRL2 OT5PX0RX Strong Genetic Variation [1129]
CCS OTXHT3QO Strong Biomarker [1136]
CCT2 OTW1VV4E Strong Altered Expression [422]
CD177 OTS79FNF Strong Altered Expression [1347]
CD200R1 OT65Q9M6 Strong Genetic Variation [722]
CD226 OT4UG0KB Strong Altered Expression [1350]
CD2AP OTC76KQM Strong Biomarker [1351]
CD5L OTPY4WQR Strong Genetic Variation [1352]
CD63 OT2UGZA9 Strong Biomarker [1353]
CD68 OTOYEY3J Strong Biomarker [480]
CD81 OTQFXNAZ Strong Genetic Variation [1354]
CD8A OTDWQJXK Strong Biomarker [1355]
CDC42SE2 OT8SG9I1 Strong Genetic Variation [1224]
CDCA5 OTZLCQ5U Strong Biomarker [467]
CDH13 OTD2CYM5 Strong Altered Expression [1356]
CDK5R2 OTNUTLPU Strong Biomarker [1291]
CDK5RAP2 OTRKEVTY Strong Genetic Variation [1357]
CDKAL1 OTA0SGNE Strong Genetic Variation [561]
CDKN2D OT2TTZPZ Strong Biomarker [1060]
CDNF OT1TP2T8 Strong Biomarker [1358]
CDR2 OTD3ZJST Strong Genetic Variation [1359]
CDSN OTQW4HV6 Strong Biomarker [1360]
CEACAM19 OTMECF5R Strong Genetic Variation [494]
CEACAM20 OTHP9H9O Strong Genetic Variation [378]
CEBPD OTNBIPMY Strong Altered Expression [1361]
CEBPZ OT11BATG Strong Biomarker [1362]
CELF2 OTLJJ4VT Strong Genetic Variation [1363]
CENPK OTKPUF8K Strong Biomarker [508]
CENPV OTPQ0KT9 Strong Biomarker [1364]
CERT1 OTNUCNHX Strong Biomarker [1365]
CETN1 OTGQ8JOZ Strong Biomarker [1366]
CFAP410 OTJ94J99 Strong Altered Expression [1367]
CFAP97 OT0RSQO4 Strong Biomarker [1368]
CFC1 OT5DHGI8 Strong Biomarker [1369]
CFDP1 OTXY7J96 Strong Altered Expression [1370]
CFL1 OTT6D5MH Strong Biomarker [1371]
CHAF1B OTOMK4KH Strong Altered Expression [1367]
CHCHD10 OTCDHAM6 Strong Genetic Variation [1372]
CHD1 OT9R9G0H Strong Biomarker [410]
CHGA OTXYX5JH Strong Biomarker [1373]
CHGB OT7SAQT2 Strong Biomarker [1374]
CHL1 OT6E6E8P Strong Biomarker [1375]
CHMP2B OTZA7RJB Strong Biomarker [1376]
CHRDL1 OTGMWVVA Strong Biomarker [1158]
CHRNA3 OTCZQY1U Strong Genetic Variation [1377]
CIB1 OT4BVCRU Strong Altered Expression [1378]
CINP OTZ31XOT Strong Biomarker [1379]
CIP2A OTVS2GXA Strong Biomarker [1380]
CISD2 OTVS7S2H Strong Biomarker [1381]
CISD3 OT0MM1MW Strong Biomarker [1382]
CISH OT8T5NYL Strong Altered Expression [1383]
CKB OTUCKOTT Strong Biomarker [1384]
CLASRP OT7B1H28 Strong Genetic Variation [378]
CLC OTYMYR85 Strong Biomarker [1385]
CLDN1 OT27KV99 Strong Biomarker [1386]
CLDN17 OTQCEYBY Strong Biomarker [1387]
CLDN5 OTUX60YO Strong Biomarker [1388]
CLDN8 OT7IIWXG Strong Altered Expression [1367]
CLEC16A OTLGV5SV Strong Genetic Variation [1209]
CLEC1B OTO38TRG Strong Altered Expression [1389]
CLEC7A OTRTBH27 Strong Biomarker [1390]
CLMN OT7U5J3T Strong Genetic Variation [515]
CLN5 OTY265P6 Strong Genetic Variation [571]
CLPTM1 OT14QP7N Strong Genetic Variation [378]
CLSTN3 OTPUFK4C Strong Altered Expression [1391]
CLUH OTCDYPZV Strong Biomarker [1392]
CNTNAP2 OT48T2ZP Strong Genetic Variation [378]
COG5 OTZEG7K0 Strong Genetic Variation [1393]
COIL OTP4I4DL Strong Biomarker [1394]
COL12A1 OTHLTV53 Strong Genetic Variation [561]
COL17A1 OTID5AH2 Strong Biomarker [1395]
COL3A1 OTT1EMLM Strong Biomarker [1396]
COL4A4 OT9G0MCT Strong Genetic Variation [561]
COQ2 OTDAKEY4 Strong Biomarker [1397]
CORO1A OTVAZOHC Strong Biomarker [1371]
COTL1 OT6YCNLF Strong Biomarker [1398]
COX1 OTG3O9BN Strong Biomarker [405]
COX10 OTCYIS0L Strong Genetic Variation [1399]
COX15 OTUIYHIW Strong Genetic Variation [1400]
COX3 OTNNGBYJ Strong Genetic Variation [588]
COX6B1 OTNKXYQI Strong Genetic Variation [1399]
CP OTM8JE4Y Strong Biomarker [1401]
CPLX1 OT7UIGTP Strong Altered Expression [1402]
CPLX2 OTU5QWFH Strong Altered Expression [1402]
CPO OTOIG8C9 Strong Biomarker [1403]
CPT1A OTI862QH Strong Altered Expression [1404]
CPVL OTOJL31C Strong Biomarker [1405]
CR1L OTX3KR7U Strong Genetic Variation [494]
CRADD OT02TZ4S Strong Genetic Variation [515]
CREB3 OT9617UO Strong Biomarker [1406]
CREB3L1 OT2JHIHM Strong Genetic Variation [1407]
CRISPLD2 OTVSFHTL Strong Biomarker [1408]
CRYL1 OT0SJSJM Strong Biomarker [1409]
CSMD1 OTIVDSC4 Strong Genetic Variation [1410]
CSN2 OT22C0PD Strong Biomarker [1411]
CST7 OTQWZUVQ Strong Altered Expression [1412]
CTBP1 OTVYH2DH Strong Biomarker [1413]
CTBS OT135K92 Strong Biomarker [894]
CTCF OT8ZB70U Strong Genetic Variation [1414]
CTDSP2 OTT2BOJG Strong Altered Expression [1415]
CTNNA2 OTJ8G92T Strong Genetic Variation [515]
CTNNA3 OT9Z0P1E Strong Genetic Variation [1416]
CTNNBL1 OT6KLHPA Strong Biomarker [1417]
CTNND1 OTUMPSHR Strong Biomarker [589]
CTNND2 OTYKE30Y Strong Genetic Variation [1418]
CTRL OTB6NA5O Strong Biomarker [1419]
CTSZ OTSCX2LL Strong Altered Expression [1420]
CTTN OTJRG4ES Strong Altered Expression [1421]
CTXN3 OT534FDX Strong Biomarker [1422]
CUL4A OTTBV70J Strong Biomarker [1423]
CUX1 OTU1LCNJ Strong Altered Expression [770]
CYCS OTBFALJD Strong Genetic Variation [515]
CYLD OT37FKH0 Strong Biomarker [543]
CYP2D7 OTYJTL3S Strong Genetic Variation [1424]
CYTB OTAHB98A Strong Altered Expression [422]
CYTH4 OTOR82ID Strong Genetic Variation [1425]
DAB1 OTPL9MA3 Strong Posttranslational Modification [1426]
DAPK1 OTNCNUCO Strong Biomarker [1427]
DAPK2 OTWODUQG Strong Biomarker [1080]
DAXX OTX6O7PL Strong Genetic Variation [1428]
DBI OT884QY9 Strong Genetic Variation [1429]
DBN1 OTZVKG8A Strong Biomarker [1430]
DCAF7 OT3W5DYL Strong Genetic Variation [561]
DCDC2 OTSUFH1H Strong Biomarker [1431]
DCX OTISR7K3 Strong Altered Expression [1432]
DDIT3 OTI8YKKE Strong Biomarker [1433]
DDX25 OTF36NBP Strong Genetic Variation [561]
DDX39A OT0Z6E1K Strong Biomarker [1118]
DDX39B OTEVCFVU Strong Biomarker [1118]
DECR1 OTCDIR6X Strong Biomarker [1434]
DEFA1 OT5N1B9B Strong Altered Expression [616]
DEFB104A OTLQZR6K Strong Genetic Variation [616]
DEGS1 OT4WXPKW Strong Biomarker [1435]
DENR OTXP9HOY Strong Biomarker [1080]
DGKQ OT8OEPYT Strong Genetic Variation [1221]
DHRS11 OTU3J0ZL Strong Biomarker [740]
DHX40 OTOL02QN Strong Genetic Variation [890]
DIAPH1 OTZBYPLH Strong Biomarker [1436]
DIO2 OTGPNSLH Strong Genetic Variation [1437]
DISC1 OT43AW4H Strong Altered Expression [1438]
DLD OT378CU9 Strong Biomarker [1439]
DLG1 OTCRZYWT Strong Biomarker [1440]
DLG2 OTQ3BD8U Strong Posttranslational Modification [1441]
DLG3 OTH591WK Strong Biomarker [1442]
DLX5 OTEEFBEU Strong Genetic Variation [561]
DMRT1 OT5PU9U1 Strong Altered Expression [1443]
DMXL1 OTWVL31L Strong Genetic Variation [515]
DNA2 OT4DJFFU Strong Biomarker [1444]
DNAJA3 OT61924T Strong Biomarker [1445]
DNAJC27 OTJRPCUR Strong Genetic Variation [1446]
DNAJC5 OTCZDXAL Strong Altered Expression [1447]
DNM1L OTXK1Q1G Strong Biomarker [1080]
DNTT OTFSEF12 Strong Genetic Variation [1448]
DOCK2 OTZTS3PA Strong Biomarker [1449]
DOCK8 OTNQLL21 Strong Biomarker [1450]
DPEP2 OTIKZDTG Strong Biomarker [820]
DPPA2 OT8Y55RY Strong Genetic Variation [1451]
DPYSL3 OTINJV20 Strong Altered Expression [1452]
DPYSL5 OT6F9T6F Strong Biomarker [706]
DROSHA OTCE68KZ Strong Genetic Variation [1453]
DSC1 OTNII6GZ Strong Genetic Variation [1454]
DSC3 OTYG47F8 Strong Biomarker [1455]
DSCAML1 OT7QURQT Strong Genetic Variation [433]
DSG1 OT11HC3A Strong Biomarker [1456]
DSG2 OTJPB2TO Strong Genetic Variation [378]
DSPP OT1TYNDN Strong Genetic Variation [1457]
DST OTHZBM4X Strong Biomarker [1458]
DUSP22 OTEZ3U85 Strong Posttranslational Modification [1459]
DUSP6 OT4H6RKW Strong Posttranslational Modification [1235]
DVL1 OTD67RF1 Strong Biomarker [1460]
DYM OTQ670WI Strong Biomarker [1461]
EBF3 OTB0IWLW Strong Biomarker [1462]
EBNA1BP2 OTBRVMZH Strong Biomarker [803]
ECD OT3L3PCU Strong Genetic Variation [1463]
ECHDC3 OTKU2RMC Strong Genetic Variation [1464]
ECSCR OT9L72MD Strong Altered Expression [1465]
ECSIT OTJX1YC7 Strong Biomarker [1466]
EDAR OT3W2UQS Strong Biomarker [1467]
EDEM2 OTQXYD65 Strong Genetic Variation [1468]
EEF1A1 OT00THXS Strong Biomarker [1469]
EEF2 OTZ7SZ39 Strong Biomarker [1470]
EFHD2 OTM9VMN3 Strong Biomarker [1471]
EFNA5 OTOH4DRR Strong Biomarker [1472]
EGR2 OTAVQ78J Strong Biomarker [1473]
EID1 OT3OI5H4 Strong Altered Expression [1474]
EIF1 OTB4GZ0V Strong Altered Expression [1475]
EIF2S1 OTM0GDTP Strong Altered Expression [1476]
EIF2S2 OTXF0B09 Strong Biomarker [1477]
EIF2S3 OTARRES9 Strong Biomarker [1477]
EIF3E OTI0WG98 Strong Genetic Variation [1478]
EIF4A1 OTMTBX6N Strong Biomarker [1479]
EIF4A2 OT08H03R Strong Biomarker [1479]
EIF4G2 OTEO98CR Strong Altered Expression [1370]
EIF5 OT79PQUN Strong Biomarker [1480]
ELAVL2 OT6EJ8MQ Strong Biomarker [1481]
ELAVL4 OT3YH6J6 Strong Biomarker [1482]
ELK1 OTH9MXD6 Strong Biomarker [1483]
ELMO1 OTY2ORXK Strong Genetic Variation [515]
ELOC OT0XHHWP Strong Biomarker [961]
EMP1 OTSZHUHQ Strong Genetic Variation [1484]
ENDOU OTB7OF7Y Strong Genetic Variation [1485]
ENO1 OTB1KWJS Strong Biomarker [1486]
EOMES OTB9VQFA Strong Genetic Variation [1083]
EPC2 OTTG0W9R Strong Biomarker [1341]
EPDR1 OT5JW5RB Strong Genetic Variation [378]
EPG5 OT3P5HQD Strong Genetic Variation [1487]
EVA1A OTCY3Q2M Strong Genetic Variation [1488]
EXOC3L4 OTFD17IL Strong Biomarker [1489]
EXOC4 OT5EWXAN Strong Genetic Variation [515]
EXOSC6 OTAC10N6 Strong Genetic Variation [1485]
EYA4 OTINGR3Z Strong Genetic Variation [561]
FABP6 OTIRQWLW Strong Biomarker [1490]
FABP7 OTRE2H4G Strong Biomarker [1491]
FAM181A OTBQCMNL Strong Genetic Variation [561]
FAM20C OTW5YZ7X Strong Biomarker [1492]
FAM3C OTBR6U9G Strong Biomarker [1493]
FAM72A OTBZYSR3 Strong Biomarker [1494]
FAM72B OT6AOG64 Strong Biomarker [1494]
FANCD2 OTVEB5LF Strong Genetic Variation [504]
FANCG OT7MC8TZ Strong Altered Expression [1495]
FARP1 OTL1EBTM Strong Genetic Variation [561]
FBXL2 OT5EZ7PD Strong Altered Expression [1496]
FBXL7 OTNUK1DJ Strong Genetic Variation [1497]
FBXO2 OTF3677S Strong Altered Expression [1498]
FBXO7 OTGTN8TJ Strong Biomarker [1499]
FCGR3B OTSLSPZG Strong Biomarker [534]
FCN2 OTTHJBKZ Strong Biomarker [467]
FERMT2 OTZNPWWX Strong Biomarker [1500]
FGF13 OTHNNVSG Strong Biomarker [1501]
FGF9 OT2SKDGM Strong Biomarker [1502]
FHL2 OT0OAYWT Strong Biomarker [1503]
FHL5 OT6C00Z1 Strong Biomarker [361]
FIS1 OT2HL10J Strong Biomarker [1504]
FKBPL OTR9ND6K Strong Biomarker [1505]
FLG OTE9QDV6 Strong Genetic Variation [1506]
FLVCR1 OT9XCFOC Strong Biomarker [1507]
FMN2 OTUY7BSV Strong Biomarker [1508]
FMR1 OTWEV0T5 Strong Genetic Variation [1509]
FNDC5 OT5CSK9X Strong Biomarker [1510]
FNIP1 OTB1CC41 Strong Genetic Variation [1224]
FOCAD OT83QOSI Strong Genetic Variation [1511]
FOSB OTW6C05J Strong Biomarker [1512]
FOXA1 OTEBY0TD Strong Altered Expression [1513]
FOXA2 OTJOCVOY Strong Altered Expression [1513]
FRK OTEKV1SC Strong Genetic Variation [1514]
FRMD4A OTJDTIK2 Strong Biomarker [1515]
FRMD6 OTY6X9V5 Strong Biomarker [1516]
FTMT OTIUX6XG Strong Biomarker [1517]
FXYD1 OTNKT6GP Strong Biomarker [1518]
FXYD6 OTHOQXGF Strong Biomarker [1519]
FZD3 OTIWDN78 Strong Altered Expression [1520]
FZD5 OTXFFY56 Strong Altered Expression [1521]
GAB1 OTQKE6V4 Strong Biomarker [1522]
GABBR1 OTU5A52J Strong Genetic Variation [1523]
GABPA OT9YB2SA Strong Altered Expression [1524]
GADD45A OTDRV63V Strong Altered Expression [1525]
GADD45GIP1 OT4IZ4TP Strong Altered Expression [1526]
GADL1 OTJM4A0R Strong Biomarker [1295]
GAL3ST1 OTSFFZRD Strong Biomarker [1115]
GAPDHS OT7YUSA5 Strong Biomarker [420]
GAPT OT6C2WXX Strong Biomarker [1527]
GAS7 OT0M5TNY Strong Biomarker [1528]
GBF1 OTY1KEHY Strong Biomarker [1529]
GCA OTAJ7ZHG Strong Genetic Variation [1530]
GCHFR OTEOT8GI Strong Biomarker [467]
GDE1 OTU6FSBF Strong Altered Expression [1531]
GDF11 OTOSNMND Strong Biomarker [1532]
GDF7 OTNZY74B Strong Biomarker [1533]
GEMIN7 OTWA67L6 Strong Genetic Variation [378]
GFER OTVK43OK Strong Biomarker [987]
GFRA1 OT3WBVYB Strong Altered Expression [1534]
GGACT OTGPZHR9 Strong Genetic Variation [561]
GKN1 OT7ZYFQ9 Strong Biomarker [1535]
GLIS1 OTBDNB26 Strong Biomarker [1536]
GLS2 OT08MSHL Strong Biomarker [1537]
GLYAT OT3WWYXD Strong Altered Expression [1007]
GMFB OTR1JN1D Strong Biomarker [1538]
GMNC OTMORU7G Strong Genetic Variation [1539]
GMPR OTERWHYM Strong Posttranslational Modification [1540]
GNA12 OT3IRZH3 Strong Biomarker [1541]
GNB3 OTA6HYBA Strong Genetic Variation [1542]
GNPAT OTF6LWPO Strong Altered Expression [1543]
GOLGA2 OT5S9KYM Strong Biomarker [1544]
GOLGA4 OTCMEHNJ Strong Biomarker [1545]
GOLGA6A OTHU9MRX Strong Biomarker [1546]
GOLIM4 OTB5NV8A Strong Genetic Variation [433]
GOLPH3 OTDLGYM3 Strong Biomarker [1547]
GORASP1 OTQS91S7 Strong Biomarker [1084]
GPAA1 OTWVRR35 Strong Genetic Variation [1103]
GPC1 OTQKRSSV Strong Altered Expression [1238]
GPC6 OTNJBESF Strong Genetic Variation [515]
GPHN OTAKK1SV Strong Genetic Variation [1548]
GPM6A OT8G13EG Strong Biomarker [1549]
GPR141 OTJ8WSSW Strong Genetic Variation [378]
GPR37L1 OTOV08EV Strong Posttranslational Modification [1235]
GPR42 OTEB0ROY Strong Biomarker [440]
GPR50 OT0EJBM4 Strong Posttranslational Modification [1550]
GPRC5B OTF3S5E3 Strong Genetic Variation [1446]
GPX4 OTRAFFX2 Strong Genetic Variation [703]
GRAMD4 OT1HXEPM Strong Biomarker [1551]
GRAP2 OTS5NIZ3 Strong Biomarker [458]
GREM2 OTE91EWT Strong Genetic Variation [1552]
GRHL3 OT1V4ZEH Strong Altered Expression [1553]
GRIN3A OTQS9GYY Strong Biomarker [1554]
GRIP1 OT958HK1 Strong Altered Expression [1555]
GSAP OT33HG7E Strong Biomarker [1556]
GSKIP OTEYSV5M Strong Biomarker [1557]
GSTM3 OTLA2WJT Strong Genetic Variation [793]
GSTT2B OTCMRDLE Strong Genetic Variation [1558]
GTDC1 OT8OBXKK Strong Biomarker [1559]
GULP1 OT1WMVDH Strong Biomarker [1560]
GYPC OTOEDR7O Strong Biomarker [1561]
H2BC12 OTQ8V0KG Strong Biomarker [468]
H4C1 OTB71W46 Strong Biomarker [603]
HAP1 OT6SG0JQ Strong Genetic Variation [1562]
HARS1 OTHOEOTS Strong Genetic Variation [1563]
HAS1 OTJIAG1W Strong Altered Expression [1564]
HAS3 OTPM8IL8 Strong Altered Expression [1564]
HBG2 OT4J48JJ Strong Genetic Variation [1565]
HCLS1 OTX7WGYN Strong Altered Expression [770]
HCN3 OTMO1ZYQ Strong Altered Expression [1566]
HDLBP OTKDEEYX Strong Genetic Variation [1296]
HEBP1 OTR9MPDX Strong Genetic Variation [1296]
HECTD2 OTDIBGQV Strong Biomarker [1567]
HECW1 OT1PVAZA Strong Genetic Variation [515]
HECW2 OTP2IN12 Strong Biomarker [1285]
HERC2 OTNQYKOB Strong Genetic Variation [561]
HEY2 OTU4J3ZI Strong Altered Expression [1568]
HGS OTCYYCAC Strong Genetic Variation [1563]
HHEX OTLIUVYX Strong Biomarker [1569]
HHIP OT77RQYS Strong Biomarker [958]
HIP1 OT7AKCFQ Strong Biomarker [1285]
HLA-DRA OT7KZMP2 Strong Altered Expression [1570]
HLA-DRB4 OTNXIHQU Strong Genetic Variation [1571]
HNRNPC OT47AK4C Strong Altered Expression [1572]
HNRNPDL OTB3BFCV Strong Altered Expression [1572]
HNRNPK OTNPRM8U Strong Biomarker [1573]
HOMER1 OTWFD3SI Strong Biomarker [1574]
HOMER2 OT4JGKJF Strong Genetic Variation [1083]
HOOK1 OTTTKV7V Strong Altered Expression [1575]
HOOK2 OTPO4NQV Strong Biomarker [1575]
HOOK3 OT0OE8SX Strong Biomarker [1575]
HP1BP3 OTTJ5LX2 Strong Biomarker [1576]
HPCA OTERUPP6 Strong Altered Expression [1577]
HPS1 OTKS5I7T Strong Genetic Variation [1578]
HPSE2 OTGEPP8V Strong Altered Expression [1579]
HS3ST1 OT5DVN9P Strong Altered Expression [1580]
HSD17B6 OTSB55D2 Strong Biomarker [1071]
HSPA14 OTZCA5LK Strong Biomarker [748]
HSPA2 OTSDET7B Strong Biomarker [1581]
HSPA4 OT5HR0AR Strong Biomarker [1582]
HSPB2 OTS01646 Strong Biomarker [746]
HSPB6 OTFPLGZI Strong Altered Expression [1583]
HSPH1 OTVRR73T Strong Altered Expression [1584]
HTRA2 OTC7616F Strong Biomarker [1585]
HYI OTFPNOTN Strong Genetic Variation [561]
HYLS1 OT3SW5UC Strong Biomarker [1586]
HYOU1 OTBGBSOV Strong Altered Expression [1587]
IARS1 OT9WXH5N Strong Biomarker [1588]
IFIT3 OTPGHZB9 Strong Altered Expression [1272]
IFITM3 OT2QP8D3 Strong Biomarker [1589]
IFT43 OTKWYQ5C Strong Altered Expression [1590]
IGSF23 OTORIW79 Strong Genetic Variation [378]
IL27RA OTSQBAKI Strong Biomarker [1591]
IL6ST OT1N9C70 Strong Biomarker [1592]
IL9R OTILCLXA Strong Altered Expression [1593]
IMMT OTBDSLE7 Strong Biomarker [1594]
INAVA OTGXNB86 Strong Biomarker [639]
ING1 OTEZBRKW Strong Biomarker [508]
INPP5K OTQFLQKA Strong Altered Expression [1595]
INPPL1 OTCDAVBQ Strong Biomarker [1268]
INS-IGF2 OTZR74BO Strong Biomarker [1596]
INSIG1 OTZF5X1D Strong Genetic Variation [561]
INSRR OT3F75WA Strong Biomarker [1597]
IPO9 OT1DGLQE Strong Biomarker [1598]
IQCJ OTOC5U9H Strong Biomarker [1599]
IREB2 OT747D24 Strong Genetic Variation [1600]
IRF2 OTAZRUW3 Strong Genetic Variation [433]
IRF6 OTKJ44EV Strong Biomarker [1601]
IRF7 OTC1A2PQ Strong Genetic Variation [1602]
IRS4 OTTOL40K Strong Genetic Variation [1603]
ITGAX OTOGIMHE Strong Biomarker [1604]
ITGBL1 OTJDHE17 Strong Biomarker [403]
ITIH4 OT460OO1 Strong Biomarker [1605]
ITPKB OTSVVPAV Strong Altered Expression [1606]
ITSN1 OT8YF3S5 Strong Biomarker [1607]
ITSN2 OT8S0OO8 Strong Genetic Variation [561]
JAM2 OTHVJJRJ Strong Genetic Variation [1083]
KALRN OT8WRCBH Strong Biomarker [1608]
KAT8 OT5LPQTR Strong Genetic Variation [378]
KAZN OTPM7BYM Strong Genetic Variation [433]
KCNE3 OTKWKR91 Strong Biomarker [1609]
KCNH4 OTHJ8WTU Strong Biomarker [1483]
KCNH8 OT3I5FLB Strong Biomarker [1483]
KCNIP3 OTCQPEM4 Strong Biomarker [1610]
KCNJ13 OTG1CNND Strong Biomarker [1611]
KCNMB2 OTBXUQGK Strong Genetic Variation [435]
KCTD2 OT8TGV8R Strong Genetic Variation [1290]
KHDRBS2 OTEKL45T Strong Genetic Variation [1612]
KHSRP OTDHZARB Strong Altered Expression [770]
KIAA0319 OTN42Y77 Strong Altered Expression [1613]
KIAA1217 OTRMK3PU Strong Biomarker [1614]
KIDINS220 OTLBH2MA Strong Biomarker [1615]
KIF17 OTHASX9G Strong Biomarker [1616]
KIF1B OTI1XQTO Strong Altered Expression [1617]
KIF21B OTFXFIU3 Strong Altered Expression [1617]
KIF6 OTDH3MR4 Strong Genetic Variation [1618]
KLC1 OTSTTTW7 Strong Altered Expression [1619]
KLF2 OTIP1UFX Strong Biomarker [1620]
KLF8 OTUC5CDB Strong Altered Expression [1621]
KLHDC8B OTKP6LCR Strong Biomarker [1158]
KLHL20 OTC0SFS9 Strong Biomarker [1622]
KLK10 OTD573EL Strong Altered Expression [390]
KPRP OTRJF3OY Strong Altered Expression [1623]
KRBOX1 OT4463UB Strong Genetic Variation [1129]
KRIT1 OT58AP1I Strong Biomarker [1332]
KRT14 OTUVZ1DW Strong Biomarker [1624]
KRT18 OTVLQFIP Strong Biomarker [1625]
L3MBTL2 OTKX1XIX Strong Altered Expression [879]
L3MBTL4 OTERBGKR Strong Genetic Variation [561]
LAMA1 OTQZMP86 Strong Genetic Variation [561]
LAMC1 OTIG527N Strong Altered Expression [1626]
LAMC3 OTKNAYJO Strong Genetic Variation [995]
LARS1 OT4557NF Strong Genetic Variation [561]
LAYN OT9A9Q1X Strong Biomarker [1433]
LBH OT87AT1X Strong Biomarker [1627]
LBR OT1HG3HG Strong Biomarker [1628]
LCMT1 OTRJQ16X Strong Genetic Variation [928]
LGALS4 OTKQCG0H Strong Altered Expression [792]
LGALS9 OT7MF91K Strong Genetic Variation [1490]
LHX2 OTK61NP8 Strong Biomarker [1629]
LIG1 OTEEQS43 Strong Genetic Variation [1630]
LIG3 OT48SKET Strong Altered Expression [1631]
LIMS1 OT729S0T Strong Biomarker [1632]
LIN28B OTVWP0FN Strong Biomarker [759]
LMF2 OT0XBGEM Strong Biomarker [1633]
LMNB1 OT100T3P Strong Biomarker [693]
LMO4 OT5NDCT9 Strong Altered Expression [1634]
LMTK2 OT93MVIC Strong Biomarker [1635]
LRAT OTB7CJKY Strong Genetic Variation [1209]
LRIG3 OT6TKZTU Strong Biomarker [1636]
LRP10 OT8490HT Strong Biomarker [1637]
LRP1B OT4YZG2N Strong Biomarker [1638]
LRPPRC OTXSK5LP Strong Biomarker [1592]
LRRC15 OTX7JL8H Strong Biomarker [1639]
LRRC4 OT7XJ70N Strong Altered Expression [1317]
LRRTM3 OTCS7EM6 Strong Biomarker [1640]
LRSAM1 OTOKWR6C Strong Biomarker [1641]
LSM2 OTHL77NY Strong Biomarker [1642]
LSR OTR8Y32X Strong Biomarker [1643]
LTBP2 OTS88GSD Strong Genetic Variation [1209]
LUZP2 OTGGOSPW Strong Genetic Variation [1644]
LYNX1 OTK4103B Strong Biomarker [1645]
LYZL4 OTO605LY Strong Altered Expression [823]
MACF1 OTVIHD77 Strong Biomarker [1646]
MADD OTUFYVGG Strong Genetic Variation [816]
MAFF OT9B7MX0 Strong Biomarker [1647]
MAGEC3 OT0KDWZN Strong Biomarker [718]
MAGEE1 OTOQQO2X Strong Biomarker [718]
MAGT1 OTQSAV5C Strong Genetic Variation [464]
MAK16 OTD546E5 Strong Biomarker [763]
MAP1B OTVXW089 Strong Altered Expression [1648]
MAP1LC3A OTPMGIU4 Strong Biomarker [1649]
MAP1LC3B OTUYHB84 Strong Altered Expression [1650]
MAP2 OT6UYT3X Strong Altered Expression [762]
MAP2K3 OTI2OREX Strong Biomarker [1651]
MAP2K4 OTZPZX11 Strong Biomarker [835]
MAP3K12 OT5HODDD Strong Biomarker [1652]
MAPK8IP3 OT0X8ACY Strong Biomarker [1653]
MASP1 OTWWCNZP Strong Biomarker [1654]
MCCC1 OTLOHEQE Strong Genetic Variation [1221]
MCF2L OTEURA8N Strong Biomarker [392]
MCM2 OTGGORIQ Strong Biomarker [1655]
MCU OTQZAYWQ Strong Biomarker [1656]
MDH1 OTJEO4E8 Strong Altered Expression [422]
MDH2 OT7364GY Strong Altered Expression [422]
MED12 OTQZ4D2X Strong Biomarker [1657]
MED12L OTT0HR5M Strong Genetic Variation [1410]
MED23 OTKZQT0R Strong Genetic Variation [758]
MEF2A OTV2SF6E Strong Altered Expression [1658]
MEF2C OTZGF1Y5 Strong Biomarker [1659]
MEF2D OT7CEIG0 Strong Altered Expression [1660]
MFAP1 OTZN4FT3 Strong Biomarker [1126]
MFF OTEVIXOM Strong Biomarker [1208]
MFSD2A OTVG1VG0 Strong Altered Expression [1661]
MGAT3 OTXI5X4T Strong Biomarker [1662]
MICAL2 OT04OQQJ Strong Genetic Variation [561]
MICB OTS2DVDW Strong Biomarker [1433]
MID1 OTWN1PGU Strong Biomarker [1663]
MILR1 OT0O30C7 Strong Biomarker [1664]
MINDY4 OTBZ2SZB Strong Biomarker [1665]
MLKL OTDSLC81 Strong Biomarker [1666]
MLLT3 OTXH4DDG Strong Genetic Variation [1667]
MMP24 OTF8T3JM Strong Genetic Variation [1668]
MMUT OTBBBV70 Strong Biomarker [1310]
MNAT1 OTXLOYCB Strong Biomarker [467]
MOAP1 OTVF3LUG Strong Biomarker [1654]
MOGAT3 OTPGLUBS Strong Altered Expression [1669]
MOV10 OT0KAY9G Strong Biomarker [1670]
MPG OTAHW80B Strong Altered Expression [1631]
MPHOSPH6 OT6E2S48 Strong Biomarker [1671]
MPI OTBH6ZK1 Strong Biomarker [1155]
MPST OTCDPH5D Strong Biomarker [828]
MPZ OTAR2YXH Strong Biomarker [1672]
MPZL1 OTJSUUHR Strong Genetic Variation [1294]
MRE11 OTGU8TZM Strong Biomarker [1673]
MS4A2 OTMCAS2D Strong Biomarker [1674]
MS4A3 OT0CEJOO Strong Biomarker [1675]
MSC OTBRPZL5 Strong Biomarker [1676]
MSRB3 OT4UZXMN Strong Biomarker [1677]
MSTO1 OT37XCNP Strong Biomarker [828]
MT3 OTVCZ7HI Strong Biomarker [1678]
MTCH2 OTV3E4GU Strong Biomarker [1679]
MTERF4 OT50CTOJ Strong Biomarker [1680]
MTHFD1 OTMKHVWC Strong Genetic Variation [1681]
MTUS1 OTBPALMU Strong Altered Expression [433]
MX1 OT6X8G5T Strong Genetic Variation [1682]
MYCL OT1MFQ5U Strong Genetic Variation [408]
MYH6 OT3YNCH1 Strong Biomarker [1683]
MYH9 OT94Z706 Strong Altered Expression [1684]
MYLIP OTL0PFGV Strong Biomarker [1685]
MYO16 OTMS3D8W Strong Genetic Variation [1686]
MYO6 OTJQYRC7 Strong Biomarker [1683]
MYOCD OTSJNHTH Strong Altered Expression [1687]
MZB1 OT071TET Strong Altered Expression [1688]
MZF1 OTMVZCPW Strong Genetic Variation [1689]
NAA25 OTS3QVF1 Strong Altered Expression [1223]
NACA OTLP1KR3 Strong Biomarker [1690]
NAE1 OTMC6F3Y Strong Genetic Variation [1691]
NANOG OTUEY1FM Strong Genetic Variation [408]
NANOS3 OTGX9IQU Strong Altered Expression [1692]
NANS OTMQ2FUH Strong Biomarker [1693]
NAP1L1 OTI7WBZV Strong Altered Expression [1223]
NAPSA OT6F8IAL Strong Altered Expression [1223]
NARS2 OTL5X535 Strong Altered Expression [1694]
NAV2 OTGAOL01 Strong Genetic Variation [1695]
NAV3 OT97M1TR Strong Altered Expression [1696]
NBEAL1 OTLJ11N3 Strong Biomarker [1697]
NBEAL2 OTMCAXWR Strong Biomarker [1698]
NCALD OTJZ8UEL Strong Altered Expression [1699]
NCAM2 OT8LBJN8 Strong Biomarker [1700]
NCAPD2 OT8VGE2O Strong Biomarker [1701]
NCAPH2 OTSASNX6 Strong Biomarker [1633]
NCKAP1 OTEZQXXJ Strong Altered Expression [1223]
NCOA6 OTOMIGTV Strong Genetic Variation [1702]
NCS1 OT6JHAWM Strong Genetic Variation [515]
ND1 OTCLGIXV Strong Genetic Variation [1703]
ND2 OTG9OHOX Strong Genetic Variation [1704]
ND4 OT4RQVAA Strong Altered Expression [1705]
NDE1 OT2N8Q17 Strong Biomarker [1706]
NDFIP1 OTIORSWF Strong Biomarker [1707]
NDP OTGDJ4US Strong Altered Expression [1708]
NDRG2 OT5L6KD7 Strong Biomarker [942]
NDUFA12 OTCD6I5M Strong Genetic Variation [1709]
NDUFA5 OTR848KZ Strong Biomarker [1519]
NDUFA6 OTEOIIOL Strong Biomarker [1710]
NDUFA9 OTMKQJJ8 Strong Biomarker [1711]
NDUFAF6 OTRJMIGT Strong Genetic Variation [1252]
NDUFB8 OTW4A4Q0 Strong Altered Expression [1712]
NECAB3 OTRASC9G Strong Altered Expression [1713]
NEFH OTMSCW5I Strong Posttranslational Modification [1714]
NEFM OT8VCBNF Strong Biomarker [1715]
NETO1 OTXP9A63 Strong Genetic Variation [1285]
NEU1 OTH9BY8Y Strong Biomarker [1716]
NEUROD1 OTZQ7QJ2 Strong Altered Expression [867]
NEUROD6 OTLFL6K8 Strong Genetic Variation [1717]
NEUROG2 OTAEMIGT Strong Biomarker [1718]
NFASC OTBDUXZT Strong Biomarker [1373]
NFATC2 OTK5T6HZ Strong Biomarker [1719]
NFATC3 OTYOORME Strong Altered Expression [1720]
NFATC4 OTTDCUAO Strong Biomarker [1721]
NFE2L1 OT1QHOS2 Strong Biomarker [1722]
NGB OTW0SIUY Strong Altered Expression [1723]
NHLRC2 OTY4HPWB Strong Biomarker [1724]
NINJ2 OTUG1AOV Strong Genetic Variation [1725]
NIT2 OTC1RAH3 Strong Genetic Variation [1410]
NKAIN2 OTI4H30Z Strong Genetic Variation [515]
NLGN1 OTGHRRFQ Strong Posttranslational Modification [1726]
NLN OTFRITPU Strong Biomarker [1300]
NLRC4 OTAIA3NA Strong Biomarker [523]
NME2 OTCYGLHV Strong Altered Expression [1727]
NME8 OT4RULP5 Strong Genetic Variation [1571]
NOC2L OTNT7R33 Strong Biomarker [1728]
NOC3L OTYOR3PV Strong Biomarker [1729]
NOCT OTVSYP2D Strong Biomarker [543]
NOG OTGRHHPG Strong Biomarker [1730]
NOL3 OT1K0L0D Strong Biomarker [1731]
NOLC1 OTKDZU0D Strong Biomarker [1732]
NOP53 OTA2YKO6 Strong Altered Expression [1272]
NPC1 OTRIPICX Strong Altered Expression [1020]
NPC2 OTE9UEJC Strong Biomarker [1733]
NPHP1 OTZHCFFQ Strong Genetic Variation [1552]
NPL OTA7P0TO Strong Genetic Variation [1734]
NPM3 OTIAM1A3 Strong Altered Expression [1480]
NPPA OTMQNTNX Strong Biomarker [1735]
NPS OTEG25A2 Strong Biomarker [1736]
NPTN OTAQKSAU Strong Biomarker [1350]
NPTX1 OTKVHCV0 Strong Biomarker [1737]
NR2C2 OTDZWVOJ Strong Altered Expression [1738]
NR2F6 OTNVO2B6 Strong Biomarker [1739]
NRBF2 OTXSUYCD Strong Biomarker [1740]
NRCAM OT80HHQ2 Strong Altered Expression [1741]
NRDC OTWBBCXO Strong Biomarker [1229]
NRF1 OTOXWNV8 Strong Biomarker [1742]
NRG3 OTIFZ5CT Strong Genetic Variation [1743]
NRIP1 OTIZOJQV Strong Altered Expression [1744]
NRXN1 OTJN1JQA Strong Biomarker [1373]
NRXN3 OTJ0I7HJ Strong Biomarker [1745]
NT5C3A OT67KZJA Strong Genetic Variation [1746]
NTN4 OTDRRMP3 Strong Genetic Variation [995]
NTS OTPGDNQS Strong Altered Expression [1747]
NUBP1 OTE8RAKZ Strong Biomarker [577]
NUBPL OTQMCSXT Strong Biomarker [1748]
NUCKS1 OTL4VJC5 Strong Genetic Variation [1221]
NUDT1 OTZSES3W Strong Altered Expression [1749]
NUDT11 OTFDXJA1 Strong Genetic Variation [1750]
NUFIP2 OTZBZ224 Strong Biomarker [1572]
NUMB OTMB586Q Strong Biomarker [1751]
NUP153 OTCAS0AR Strong Altered Expression [1752]
NUP160 OTUKVV3I Strong Altered Expression [1753]
NUP98 OTNT12G2 Strong Altered Expression [1230]
NXF1 OTEFHXG6 Strong Genetic Variation [1754]
OAS3 OT6E5FYS Strong Biomarker [868]
OCA2 OTDWIGBF Strong Genetic Variation [1755]
OCIAD2 OTSWB4SZ Strong Altered Expression [1756]
OCLN OTSUTVWL Strong Biomarker [1757]
OCM OTQRML29 Strong Biomarker [1758]
ODF1 OTTSURLA Strong Biomarker [1759]
OGA OT7ZBWT1 Strong Biomarker [1760]
OGT OT1Z1ZXE Strong Biomarker [1761]
OLFM1 OTOYPEWW Strong Biomarker [1762]
OMA1 OT0JRVY7 Strong Biomarker [1763]
OMP OT7JH0DY Strong Altered Expression [1764]
OPN1LW OTFNUZ7O Strong Biomarker [1765]
OPN1MW OTPJ7LX4 Strong Biomarker [1766]
OPN4 OT1LZ7TS Strong Biomarker [1767]
OPTN OT2UXWH9 Strong Biomarker [372]
OR2AG1 OTEITRP4 Strong Genetic Variation [1768]
OR8J1 OTWWGQW0 Strong Altered Expression [1769]
ORM1 OTZKSBRE Strong Biomarker [1770]
ORM2 OTRJGZP8 Strong Biomarker [1771]
OSBPL6 OT0NCUUA Strong Genetic Variation [561]
OSTN OTL4A57N Strong Genetic Variation [1539]
OTOF OTXQMJY8 Strong Genetic Variation [561]
OTUB1 OT8WWM9O Strong Biomarker [1772]
OXA1L OTS0BFRD Strong Genetic Variation [1773]
OXT OT48M72Z Strong Altered Expression [1774]
P2RX2 OT0LF34A Strong Genetic Variation [886]
P2RX5 OTLBR20R Strong Genetic Variation [886]
P2RX6 OT1FNTXA Strong Genetic Variation [886]
P4HB OTTYNYPF Strong Biomarker [1775]
PABPC4 OTICKKBQ Strong Biomarker [1162]
PABPN1 OT3MC5SE Strong Biomarker [1776]
PADI1 OT13WAQX Strong Biomarker [1777]
PADI2 OTT40K94 Strong Biomarker [1778]
PAFAH1B2 OTRDWN2V Strong Genetic Variation [732]
PAG1 OTFOJUIQ Strong Biomarker [1765]
PAGR1 OTXR5PQ8 Strong Biomarker [683]
PAK3 OT80M3BV Strong Altered Expression [1779]
PALM2AKAP2 OTI618VF Strong Genetic Variation [1780]
PANK2 OTFBW889 Strong Biomarker [987]
PARD3 OTH5BPLO Strong Biomarker [660]
PARN OTTG4PE3 Strong Altered Expression [1781]
PARVB OT9OGVWX Strong Genetic Variation [515]
PAXIP1 OTRHTKG3 Strong Genetic Variation [1782]
PC OT6O0V51 Strong Biomarker [1783]
PCBP4 OTDLL4NB Strong Biomarker [1765]
PCLAF OTMVIOUU Strong Biomarker [1784]
PCP4 OTM1XXYX Strong Biomarker [1785]
PCSK1N OT7ZRW2F Strong Biomarker [1786]
PDC OT1UUVYY Strong Biomarker [1787]
PDCD4 OTZ6NXUX Strong Biomarker [1788]
PDCL3 OTD3WGV1 Strong Biomarker [561]
PDE8B OT4217NK Strong Biomarker [1789]
PDIA2 OTC2WMXS Strong Biomarker [1777]
PDIA6 OT8YBR17 Strong Altered Expression [1790]
PDP1 OT82RTMT Strong Biomarker [1791]
PDSS2 OTEOQBMX Strong Biomarker [1792]
PDYN OTEJ6430 Strong Biomarker [1793]
PDZD2 OTPPVRGY Strong Genetic Variation [1794]
PELI1 OTMLBCLC Strong Biomarker [1795]
PENK OT8P3HMP Strong Altered Expression [1796]
PER2 OTU2B1DJ Strong Genetic Variation [1154]
PFDN5 OTTKPTUP Strong Altered Expression [1797]
PGP OT6QQ7OR Strong Biomarker [1798]
PHB2 OTCAX3AW Strong Altered Expression [904]
PHF13 OT89FV4A Strong Biomarker [1799]
PHF14 OTZT3GV1 Strong Genetic Variation [561]
PHF6 OT8DXI40 Strong Biomarker [1800]
PICK1 OT8QE6EU Strong Biomarker [1801]
PIEZO1 OTBG1FU4 Strong Altered Expression [1802]
PIK3C3 OTLUM9L7 Strong Biomarker [1649]
PIK3R2 OTZSUQK5 Strong Biomarker [1417]
PIK3R3 OTXGJ8N1 Strong Biomarker [448]
PILRA OTBE0PLF Strong Genetic Variation [378]
PIN4 OT403QC1 Strong Biomarker [1803]
PINK1 OT50NR57 Strong Biomarker [1804]
PITX2 OTWMXAOY Strong Biomarker [1805]
PIWIL1 OT7CRGZ3 Strong Genetic Variation [1616]
PIWIL4 OTDA9MY0 Strong Genetic Variation [1616]
PKP4 OTQHOF8L Strong Biomarker [1806]
PLA2G15 OT6VJTPA Strong Biomarker [1122]
PLA2G3 OT3K7TMY Strong Biomarker [1807]
PLAAT1 OTM3M6P4 Strong Genetic Variation [1808]
PLAG1 OTT9AJQY Strong Biomarker [872]
PLCG2 OTGVC9MY Strong Genetic Variation [1809]
PLCL1 OTJL2C79 Strong Genetic Variation [1810]
PLD4 OT5I74II Strong Biomarker [1811]
PLEK OTB73XXA Strong Biomarker [1266]
PLEKHG5 OTL0S21W Strong Genetic Variation [1812]
PLEKHM2 OT4ZYV73 Strong Altered Expression [1595]
PLIN2 OTRXJ9UN Strong Genetic Variation [799]
PLP1 OT8CM9CX Strong Biomarker [1813]
PLPP4 OTH5EXZC Strong Genetic Variation [515]
PLXNA2 OTNNBJMQ Strong Biomarker [1814]
PLXNA3 OTMZIBVG Strong Biomarker [1815]
PLXNA4 OT5XKB3Q Strong Biomarker [1816]
PLXNB1 OTCA7JIT Strong Biomarker [1817]
PM20D1 OTXXNQ5K Strong Biomarker [597]
PNO1 OT010GIS Strong Biomarker [763]
PNPLA2 OTR3ERMR Strong Biomarker [981]
PNPLA7 OT5VSJX2 Strong Genetic Variation [561]
POLD1 OTWO4UCJ Strong Biomarker [1818]
POLDIP2 OT8SZSJ6 Strong Biomarker [458]
POLE3 OTOELRF6 Strong Biomarker [1494]
POTEM OT7L2HGH Strong Biomarker [361]
POU2F1 OTK7ELJ0 Strong Biomarker [1819]
POU2F3 OTIOOJWD Strong Biomarker [1820]
POU3F4 OTKF5AF7 Strong Altered Expression [1821]
POU5F1 OTDHHN7O Strong Genetic Variation [408]
PPARGC1A OTHCDQ22 Strong Biomarker [1822]
PPFIA1 OTYYFA9C Strong Biomarker [1823]
PPIC OTY5Q42N Strong Biomarker [1803]
PPIG OTZ8BTTM Strong Genetic Variation [1824]
PPIL1 OTS5S837 Strong Biomarker [1505]
PPL OTTM4WDO Strong Biomarker [1825]
PPP1CB OTYFTYFR Strong Altered Expression [1826]
PPP1R15A OTYG179K Strong Biomarker [1790]
PPP1R1A OTGTAGCV Strong Biomarker [1827]
PPP1R1B OTSIJMQ9 Strong Biomarker [1828]
PPP1R37 OTQQ3E4X Strong Genetic Variation [494]
PPP1R3B OTVCRXEZ Strong Genetic Variation [1342]
PPP1R42 OTN1HRBN Strong Genetic Variation [561]
PPP1R9B OTDCTHTT Strong Biomarker [1829]
PPP2R1A OTYA3GB4 Strong Genetic Variation [1830]
PPP2R2B OTSFVC82 Strong Genetic Variation [1831]
PPP2R5E OT8GPFT5 Strong Altered Expression [1832]
PPP3R1 OTGQNFJQ Strong Biomarker [1833]
PPP4R3A OTXTCULM Strong Biomarker [1834]
PQBP1 OTXCBEAH Strong Biomarker [1835]
PRB1 OTV0SYMD Strong Genetic Variation [1836]
PRDM6 OTKY12D9 Strong Biomarker [1795]
PRDX1 OTZ3BEC4 Strong Biomarker [1837]
PRDX3 OTLB2WEU Strong Altered Expression [1838]
PRG2 OT0BCPQG Strong Biomarker [1839]
PRIMA1 OT9ITT3P Strong Biomarker [1840]
PRKAA1 OT7TNF0L Strong Biomarker [1841]
PRKAA2 OTU1KZPV Strong Biomarker [1841]
PRKAB1 OT1OG4QZ Strong Biomarker [1841]
PRKACB OT6RMDCE Strong Genetic Variation [968]
PRKAR1B OT777OHS Strong Genetic Variation [1842]
PRKN OTJBN41W Strong Biomarker [1843]
PRKRA OTUTVZZU Strong Biomarker [1844]
PRLH OTJBP360 Strong Posttranslational Modification [1845]
PRM3 OT6574BF Strong Genetic Variation [1846]
PRND OTH4EEMI Strong Genetic Variation [1847]
PROK2 OT70IFEZ Strong Biomarker [1848]
PROM2 OTT8IVS7 Strong Posttranslational Modification [1849]
PROS1 OTXQWNOI Strong Biomarker [1850]
PRPF19 OTQ1STV3 Strong Biomarker [1851]
PRPF6 OT3U0ABN Strong Biomarker [1000]
PRRC2C OTBX3MXM Strong Genetic Variation [515]
PRRX1 OTTZK5G8 Strong Biomarker [1852]
PRRX2 OT8UR4AU Strong Biomarker [1853]
PRSS21 OT8ZYC7G Strong Genetic Variation [1854]
PRSS3 OTN3S5YB Strong Biomarker [1855]
PRX OT34Z10B Strong Biomarker [1856]
PSD OTUZIXUZ Strong Biomarker [1857]
PSMB2 OTX0UG5W Strong Biomarker [1858]
PSMD2 OT6HZHN7 Strong Altered Expression [1370]
PSMD3 OT585WY8 Strong Biomarker [1858]
PSMD7 OT7PZZ4K Strong Biomarker [803]
PTBP2 OTF4S7NE Strong Biomarker [1859]
PTCD1 OT7U0C5Y Strong Genetic Variation [1860]
PTCD2 OTXQ59IZ Strong Biomarker [1861]
PTCRA OTQTO5QZ Strong Biomarker [652]
PTDSS1 OTXLIBD7 Strong Biomarker [1360]
PTF1A OT7SWA57 Strong Biomarker [1862]
PTGES3 OTPPQWI0 Strong Biomarker [1060]
PTPA OTRGFOI7 Strong Altered Expression [1441]
PTPN4 OT6SXU5Y Strong Biomarker [1863]
PTPN5 OT2H1KDK Strong Altered Expression [1864]
PTPRG OT9N2WOF Strong Genetic Variation [561]
PURA OT975ELW Strong Biomarker [1865]
PVALB OTZW1WVQ Strong Biomarker [1866]
PVR OT3N91T7 Strong Genetic Variation [816]
PYCARD OT67RON3 Strong Biomarker [1032]
QRFP OTX5FZDJ Strong Biomarker [1867]
QRFPR OT31N14I Strong Biomarker [1867]
QRICH1 OTPVAX04 Strong Biomarker [1551]
RAB10 OT8ZN26V Strong Biomarker [1868]
RAB11A OTC4FW0J Strong Biomarker [1869]
RAB11B OT6GI23M Strong Biomarker [1869]
RAB21 OTH3WGLG Strong Biomarker [1870]
RAB27A OT9SQRWY Strong Altered Expression [1871]
RAB27B OTPF9D0K Strong Biomarker [1872]
RAB29 OTDZT6LP Strong Genetic Variation [1221]
RAB31 OTMLXQZ0 Strong Biomarker [1873]
RAB38 OTU0NZU0 Strong Genetic Variation [1316]
RAB3A OT2GIUO5 Strong Biomarker [1874]
RAB3D OTGKRR3C Strong Genetic Variation [561]
RAB3GAP1 OT4DQ8F2 Strong Biomarker [1732]
RAB4A OT7BL9WW Strong Biomarker [1875]
RAB6A OTLS86J5 Strong Biomarker [1876]
RAB7B OT60A0E9 Strong Biomarker [802]
RABEP1 OTQROTGT Strong Biomarker [1877]
RABEPK OTCZSREH Strong Biomarker [803]
RABGEF1 OTWC3Z3R Strong Biomarker [1878]
RAC2 OTAOHFNH Strong Biomarker [1879]
RAD23B OT0PGOG3 Strong Biomarker [1880]
RAD52 OT0OTDHI Strong Altered Expression [1881]
RAMP2 OTGQXLH5 Strong Biomarker [1882]
RAN OT2TER5M Strong Altered Expression [1883]
RANBP9 OTM8COM5 Strong Biomarker [1598]
RAP1A OT5RH6TI Strong Biomarker [1878]
RAPGEF6 OTR1QQA3 Strong Genetic Variation [1224]
RARRES2 OT1BJE8K Strong Biomarker [1884]
RASGRF1 OTNWJ7EN Strong Biomarker [1192]
RBBP6 OTTVG4HU Strong Biomarker [1844]
RBFOX1 OTFPKEL7 Strong Biomarker [1885]
RBL2 OTBQSOE6 Strong Biomarker [1732]
RBM3 OTAJ7R31 Strong Biomarker [1886]
RBM45 OTWTHD77 Strong Genetic Variation [1887]
RBM8A OT5SR6G0 Strong Altered Expression [961]
RBMS3 OTFSC9MR Strong Biomarker [763]
RCAN1 OT1MVXC7 Strong Biomarker [1888]
RCBTB1 OTAYELI8 Strong Biomarker [1546]
RCOR1 OTREADPC Strong Altered Expression [1889]
REEP5 OTZU4TJI Strong Altered Expression [944]
RELB OTU3QYEF Strong Genetic Variation [378]
REM1 OTUXL0HC Strong Genetic Variation [1890]
RER1 OTTBAUBP Strong Biomarker [1891]
RETN OTW5Z1NH Strong Genetic Variation [1892]
RFC1 OT3L5PK3 Strong Genetic Variation [1893]
RGCC OTYJMLWM Strong Biomarker [1894]
RGN OTD04KB1 Strong Altered Expression [1895]
RHBDD1 OTL5J132 Strong Biomarker [1668]
RHBDL3 OTZ7Y93J Strong Biomarker [1896]
RIN3 OT5Z6F8O Strong Genetic Variation [1351]
RMDN1 OTE1NB6U Strong Biomarker [1897]
RMDN2 OTK5WSFI Strong Biomarker [1897]
RMDN3 OTKO7AUM Strong Biomarker [1897]
RNASE1 OTKZ7CO9 Strong Biomarker [955]
RNF112 OT0Q9OUQ Strong Biomarker [1898]
RNF146 OTE4CO7E Strong Altered Expression [1899]
RNF19A OTKWCV80 Strong Biomarker [458]
RNF213 OT4OVE9O Strong Biomarker [468]
RNFT2 OTGIY43B Strong Genetic Variation [961]
ROM1 OTE7H0YV Strong Biomarker [1900]
ROPN1L OTRWZJ68 Strong Biomarker [485]
RPA1 OT76POLP Strong Biomarker [1631]
RPL13 OTFKNTD6 Strong Biomarker [1901]
RPL29 OTUFIBJL Strong Biomarker [958]
RPS21 OT6P58W6 Strong Biomarker [1902]
RPS23 OTAJMUPF Strong Altered Expression [1903]
RPS3A OTUEP7CL Strong Genetic Variation [1904]
RPS6 OTT4D1LN Strong Biomarker [1905]
RRAS OTBBF28C Strong Biomarker [1060]
RREB1 OT62460U Strong Genetic Variation [1906]
RSPO4 OTFX5N3G Strong Genetic Variation [433]
RTL1 OTOT33IM Strong Biomarker [1907]
RTN3 OTGZ51QF Strong Biomarker [1304]
RYR2 OT0PF19E Strong Biomarker [1908]
RYR3 OT4EHIP4 Strong Genetic Variation [1909]
S100A10 OTI71243 Strong Genetic Variation [1485]
SAA2 OTYAVJWG Strong Altered Expression [1910]
SAMD4A OT4MKCC8 Strong Biomarker [1911]
SAMD9 OTDG48P0 Strong Genetic Variation [1912]
SAP30L OTI15CY4 Strong Genetic Variation [515]
SAR1B OT0JZOMY Strong Genetic Variation [1913]
SARDH OTQ49Q27 Strong Biomarker [396]
SART3 OTC1AM7S Strong Biomarker [868]
SBNO1 OTNX3RL0 Strong Biomarker [1914]
SBNO2 OT1C6J3K Strong Biomarker [1914]
SBSN OT89RKJH Strong Biomarker [1915]
SCD5 OTSSUQ3Z Strong Biomarker [1916]
SCG2 OTXWUQQL Strong Biomarker [1373]
SCGN OTGD7SKH Strong Biomarker [1134]
SCIMP OT9BF7RC Strong Genetic Variation [1252]
SCP2 OTPAFCPQ Strong Altered Expression [1415]
SDC3 OT1P0LJM Strong Altered Expression [1917]
SDCBP2 OT1AT2OL Strong Altered Expression [1918]
SDF4 OTQ7WFYW Strong Biomarker [1366]
SDS OT5WTJ2M Strong Genetic Variation [1919]
SEL1L OTC0FB7T Strong Genetic Variation [1920]
SELENOM OTJ7PORS Strong Genetic Variation [1921]
SELENOP OT02B8IR Strong Biomarker [1922]
SELENOS OTUEWIU9 Strong Altered Expression [1923]
SEMA5A OTUOIOJV Strong Genetic Variation [1924]
SEMA6A OTDQ7QAW Strong Biomarker [1925]
SEPTIN1 OT4GVSU3 Strong Biomarker [1926]
SEPTIN2 OT3G33TM Strong Biomarker [1926]
SEPTIN8 OTSZLI64 Strong Altered Expression [1927]
SERPINB1 OT5RDUFO Strong Genetic Variation [1536]
SERPINB6 OT7G55IK Strong Biomarker [1928]
SERPINE2 OTYF5340 Strong Altered Expression [1929]
SERPINF2 OTZGAF8B Strong Genetic Variation [1930]
SERPINI1 OTUJHIJW Strong Biomarker [1931]
SESN3 OTJRY1Y5 Strong Biomarker [1932]
SETMAR OTE2MIMZ Strong Biomarker [1907]
SETX OTG3JNOQ Strong Genetic Variation [1933]
SEZ6 OTCD8K5D Strong Biomarker [1934]
SEZ6L2 OTUIKN2I Strong Biomarker [1030]
SFPQ OTLCIAPJ Strong Biomarker [763]
SFTPA1 OT87XL1U Strong Biomarker [1935]
SFTPC OTIZJD09 Strong Biomarker [1936]
SGK3 OTQ6QO99 Strong Genetic Variation [561]
SGMS1 OTZQE7PW Strong Biomarker [1937]
SGMS2 OT3NHO99 Strong Altered Expression [1937]
SH2B1 OTJZO2CI Strong Biomarker [1938]
SH2D3C OTAGXO0N Strong Biomarker [1939]
SH2D4B OTM0KLPH Strong Genetic Variation [1224]
SH3GL2 OTOE443G Strong Biomarker [1388]
SH3GLB1 OTAZ5OP8 Strong Biomarker [1208]
SH3PXD2A OTYRQJIH Strong Genetic Variation [1225]
SH3RF1 OT7MYGYO Strong Genetic Variation [561]
SHANK1 OTK8PV0S Strong Biomarker [1940]
SHANK2 OTSQTPFQ Strong Genetic Variation [1941]
SHBG OTPWU5IW Strong Genetic Variation [1343]
SIDT2 OTU2L002 Strong Altered Expression [1942]
SIGLEC7 OTNDLURR Strong Altered Expression [770]
SIM2 OT0QWHK4 Strong Biomarker [1943]
SIMC1 OT3GKXGI Strong Genetic Variation [1478]
SIRPB1 OTGHALWJ Strong Biomarker [762]
SIT1 OT7MDF09 Strong Biomarker [1944]
SKIL OTNBXH32 Strong Biomarker [1914]
SLA2 OTNVE666 Strong Genetic Variation [1140]
SLBP OTVYYQRT Strong Genetic Variation [1296]
SLC16A4 OT1YXBKC Strong Biomarker [993]
SLC25A48 OTAMLAGE Strong Genetic Variation [433]
SLIT3 OTU8MKEU Strong Biomarker [1012]
SLN OTERIU75 Strong Biomarker [1945]
SLTM OT0VRZA6 Strong Biomarker [964]
SMIM10L2B OT04IG2N Strong Altered Expression [1946]
SMIM20 OTZI1KFR Strong Altered Expression [1947]
SMPD3 OTHQBETH Strong Biomarker [1948]
SNAP91 OTE3EXWZ Strong Biomarker [1327]
SNCAIP OTH8VNOK Strong Altered Expression [1949]
SND1 OTT734JN Strong Biomarker [868]
SNRNP70 OTP52YZ3 Strong Biomarker [1950]
SNRPG OTWX4XK1 Strong Biomarker [1911]
SNTG1 OT6GBQHI Strong Genetic Variation [1280]
SNW1 OTKWG3PS Strong Altered Expression [1595]
SNX12 OTARRSWB Strong Altered Expression [1951]
SNX27 OTVPS7S0 Strong Biomarker [1952]
SNX3 OTXL5W8F Strong Genetic Variation [1953]
SNX8 OTMG63Z6 Strong Biomarker [1954]
SNX9 OTLNQ0ZM Strong Genetic Variation [561]
SOAT1 OTB4Y5RJ Strong Biomarker [351]
SOCS4 OTIRULFZ Strong Biomarker [1383]
SOCS7 OT503VJG Strong Biomarker [1383]
SOD3 OTIOZQAB Strong Biomarker [1955]
SORBS2 OTJSX44Y Strong Biomarker [1245]
SORBS3 OTVEUODC Strong Biomarker [1956]
SORCS2 OTBF3DYK Strong Genetic Variation [1957]
SORCS3 OT4VOMBC Strong Genetic Variation [561]
SOS1 OTTCWXC3 Strong Biomarker [1192]
SOS2 OTV3XRE5 Strong Biomarker [1958]
SOX3 OT1CRCOB Strong Altered Expression [1959]
SOX6 OTT0W0LE Strong Altered Expression [1960]
SP6 OTRAB1PN Strong Genetic Variation [515]
SPAG11A OTNQ9UB0 Strong Biomarker [946]
SPAG9 OT45AHMB Strong Biomarker [987]
SPARCL1 OT74DWMV Strong Altered Expression [1961]
SPAST OTIF3AJI Strong Genetic Variation [1962]
SPC25 OTCAS0OH Strong Biomarker [1839]
SPCS1 OTUHQ4UC Strong Altered Expression [1963]
SPECC1 OTPEML48 Strong Genetic Variation [1964]
SPEN OT37A2MD Strong Biomarker [1382]
SPHKAP OT5RHUYJ Strong Altered Expression [1595]
SPNS2 OTPODAPU Strong Biomarker [1965]
SPPL2A OTCVF6MM Strong Biomarker [1966]
SPPL2B OTI1PHMP Strong Biomarker [1967]
SPRED2 OTUX685J Strong Genetic Variation [561]
SREK1 OT3F6ZCB Strong Altered Expression [1968]
SREK1IP1 OTI29LKO Strong Altered Expression [1968]
SRF OTW18FQN Strong Altered Expression [1687]
SRL OT7IEBWZ Strong Biomarker [396]
SRM OT4N5MDP Strong Biomarker [1969]
SRRM2 OTSIMMC9 Strong Biomarker [763]
SRSF1 OTF61HOV Strong Biomarker [1970]
SRSF2 OTVDHO6U Strong Genetic Variation [1971]
SRSF3 OTOFT707 Strong Altered Expression [1972]
SRSF5 OTC5WP98 Strong Genetic Variation [1563]
SRSF6 OTGLOSYE Strong Biomarker [1973]
ST13 OTNML6UP Strong Biomarker [958]
ST18 OTPRIMTA Strong Genetic Variation [515]
ST3GAL4 OTNENJZQ Strong Biomarker [1676]
ST6GAL1 OT7US3NO Strong Genetic Variation [1974]
ST8SIA1 OTGND2YZ Strong Genetic Variation [1975]
STAG3 OTEV0AOD Strong Genetic Variation [378]
STAM2 OT9OBWPH Strong Genetic Variation [1296]
STEAP1B OTZJDFWK Strong Genetic Variation [1976]
STIM1 OT8CLQ1W Strong Altered Expression [1977]
STIM2 OTYNXAW0 Strong Altered Expression [1978]
STING1 OTDAP4G0 Strong Biomarker [1979]
STIP1 OT7TXLOX Strong Biomarker [1980]
STMN2 OT0FUHLH Strong Biomarker [1981]
STOX1 OTED3YVO Strong Altered Expression [1982]
STRADA OTG1Z6TY Strong Genetic Variation [561]
STUB1 OTSUYI9A Strong Altered Expression [1983]
STX1A OTSBUZB4 Strong Genetic Variation [1016]
STX1B OTSW59X0 Strong Biomarker [769]
STX8 OTFOJCHI Strong Biomarker [1984]
STXBP1 OTRYA8C3 Strong Biomarker [1985]
SUCLG2 OT0KHLY2 Strong Altered Expression [1986]
SUGP1 OT7W0EB8 Strong Altered Expression [1572]
SUMO2 OT1Y5IKN Strong Genetic Variation [1987]
SUOX OTEJQ9FC Strong Altered Expression [1222]
SURF1 OTAINRSS Strong Biomarker [1399]
SV2B OTAO5WIU Strong Biomarker [1988]
SV2C OTIH108W Strong Biomarker [1988]
SYBU OT3FQV7N Strong Biomarker [1897]
SYCP2 OTBH622S Strong Altered Expression [1415]
SYN1 OTMNPWC1 Strong Biomarker [1989]
SYN2 OTK0DEGH Strong Altered Expression [1990]
SYNE1 OTSBSLUH Strong Altered Expression [1991]
SYNGR1 OT0MBUK5 Strong Biomarker [1402]
SYNGR3 OTWXOOPZ Strong Biomarker [1992]
SYNM OTOI8TRJ Strong Biomarker [1993]
SYNPO OTICDJAB Strong Biomarker [1994]
SYPL2 OT6CV0CA Strong Altered Expression [1995]
SYT1 OTVTPOI6 Strong Biomarker [1005]
SZT2 OTB4FVP4 Strong Genetic Variation [561]
TAB3 OT1ECMDL Strong Altered Expression [1223]
TANK OTZSGFIK Strong Biomarker [1996]
TAOK2 OTNUMOZ1 Strong Biomarker [1030]
TAP2 OTWSYFI7 Strong Genetic Variation [1477]
TAPBPL OTTS1YNP Strong Genetic Variation [1997]
TARBP2 OT1QQ8H3 Strong Genetic Variation [1453]
TAT OT2CJ91O Strong Biomarker [1998]
TBC1D8 OT2011SS Strong Biomarker [1999]
TBP OT6C0S52 Strong Genetic Variation [2000]
TBPL1 OT4I143E Strong Biomarker [1040]
TBX2 OTTOT7A9 Strong Altered Expression [2001]
TCL1B OT4CSO39 Strong Biomarker [2002]
TCN2 OT41D0L3 Strong Genetic Variation [2003]
TCP1 OT1MGUX9 Strong Genetic Variation [1153]
TDRD9 OTS4UBI8 Strong Biomarker [1586]
TECPR2 OT1UFECZ Strong Biomarker [1379]
TERF2IP OT3M5P3G Strong Biomarker [1878]
TET1 OTZDHT1D Strong Biomarker [2004]
TFDP1 OT6RZ7VT Strong Altered Expression [944]
TFEB OTJUJJQY Strong Biomarker [2005]
TFF3 OTJJDRTU Strong Biomarker [2006]
TFIP11 OT7NVSWU Strong Biomarker [2007]
TFPI2 OTZCRWOR Strong Altered Expression [2008]
THSD4 OTXDBMDC Strong Genetic Variation [561]
THY1 OTVONVTB Strong Biomarker [2009]
TIA1 OTGPN3P8 Strong Biomarker [854]
TIGAR OTR7NMRJ Strong Altered Expression [2010]
TIMP1 OTOXC51H Strong Biomarker [2011]
TIMP2 OT8S1RRP Strong Biomarker [2012]
TIMP4 OT8A68SW Strong Biomarker [466]
TLE1 OT50MRZ1 Strong Biomarker [2013]
TLE3 OTR9PH95 Strong Biomarker [2014]
TLE5 OTEH0BFG Strong Genetic Variation [2015]
TLN2 OT10QQBC Strong Biomarker [2016]
TM2D3 OT6MS96W Strong Genetic Variation [1724]
TM7SF2 OTILU5S7 Strong Altered Expression [438]
TMC5 OTO5D86M Strong Genetic Variation [561]
TMEFF2 OT1WZ2QO Strong Biomarker [2017]
TMEM106B OTUWA6NW Strong Genetic Variation [435]
TMEM11 OTL9HDEY Strong Biomarker [1155]
TMEM119 OT0HFEIC Strong Biomarker [2018]
TMEM132C OT3297S6 Strong Genetic Variation [561]
TMEM163 OTCT1Y1L Strong Genetic Variation [1221]
TMEM175 OT6DUIYC Strong Genetic Variation [1221]
TMEM176B OTEGF2BV Strong Biomarker [2019]
TMEM201 OTZBZ4MC Strong Biomarker [2013]
TMEM54 OTPQEFR0 Strong Altered Expression [1324]
TNFAIP1 OT37EWR0 Strong Biomarker [2020]
TNFAIP6 OT1SLUZH Strong Biomarker [2021]
TNFAIP8L2 OTII0RM0 Strong Altered Expression [2022]
TNFRSF6B OTKAN9G7 Strong Biomarker [2023]
TNMD OTHLVA9G Strong Biomarker [543]
TNR OTVJGAFN Strong Biomarker [2024]
TNRC6A OT493IOM Strong Genetic Variation [515]
TNS3 OTPG2D8Z Strong Biomarker [2025]
TOLLIP OTYEO4NR Strong Biomarker [2026]
TOM1 OT30QA56 Strong Altered Expression [2027]
TOMM20 OT76TPR2 Strong Biomarker [2028]
TOMM70 OT8QBYZ0 Strong Biomarker [2028]
TOPORS OT1ERFFQ Strong Biomarker [1433]
TP53BP2 OTOWJ2Y4 Strong Biomarker [2029]
TP53INP1 OT2363Z9 Strong Biomarker [2030]
TPK1 OTCHPUD0 Strong Genetic Variation [2031]
TPM1 OTD73X6R Strong Biomarker [2032]
TPSG1 OTDESHKT Strong Biomarker [2033]
TRA2B OTZYQW52 Strong Altered Expression [2034]
TRADD OTBOSJHO Strong Altered Expression [2035]
TRAF2 OT1MEZZN Strong Biomarker [1996]
TRAM1 OT3I0H8E Strong Biomarker [2036]
TRAT1 OTMPUNPD Strong Biomarker [2037]
TREML1 OTMJD2HI Strong Genetic Variation [2038]
TREML2 OTKQGKVJ Strong Genetic Variation [2039]
TREX1 OTQG7K12 Strong Biomarker [2040]
TRIB3 OTG5OS7X Strong Biomarker [2041]
TRIM13 OTQIUACB Strong Biomarker [2042]
TRIML2 OT5QWTD2 Strong Biomarker [2037]
TRIQK OT2BXCL0 Strong Genetic Variation [433]
TRIT1 OTCU9FS5 Strong Biomarker [2043]
TRMO OTNJ7K9K Strong Altered Expression [1223]
TRPC4AP OTNJ9IFS Strong Genetic Variation [1468]
TSC22D3 OT03UM03 Strong Altered Expression [2044]
TSHZ1 OTYQ9ECW Strong Biomarker [2040]
TSPAN15 OTNQXXIG Strong Altered Expression [2045]
TSPAN16 OTIWCL05 Strong Genetic Variation [561]
TSPAN3 OT7WS6ZI Strong Altered Expression [2046]
TSPAN31 OT8WQ83R Strong Biomarker [1693]
TSPOAP1 OTAM8SGF Strong Genetic Variation [1046]
TSPY1 OTPY57X4 Strong Biomarker [2047]
TSPY3 OTQK3AKI Strong Biomarker [2047]
TTBK2 OT90YSM5 Strong Biomarker [2048]
TTC7A OTDHLPQM Strong Biomarker [910]
ABI3 OTQTDSHP Definitive Genetic Variation [2049]
BCL3 OT1M5B95 Definitive Genetic Variation [816]
CADPS2 OTV1FW0M Definitive Genetic Variation [2050]
DCHS2 OTGZJ6KS Definitive Genetic Variation [2051]
GLIS3 OTBC960E Definitive Biomarker [2052]
IL34 OTZ15VVK Definitive Genetic Variation [433]
IL6R OTCQL07Z Definitive Genetic Variation [1129]
MEGF10 OTILSPJ6 Definitive Biomarker [2053]
SPI1 OTVCA1D0 Definitive Biomarker [1658]
TRIP4 OTA8OASA Definitive Biomarker [2054]
------------------------------------------------------------------------------------
⏷ Show the Full List of 1411 DOT(s)

References

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13 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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22 ClinicalTrials.gov (NCT03116126) Randomised Clinical Trial of Noradrenergic Add-on Therapy With Extended-Release Guanfacine in Alzheimer's Disease. U.S.National Institutes of Health.
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29 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
30 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6930).
31 ClinicalTrials.gov (NCT04229927) A Multicenter, Randomized, Double-blind, Active-controlled, Phase III Clinical Trial to Evaluate the Efficacy and Safety of BPDO-1603 in Patients With Moderate-to-severe Alzheimer's Disease. U.S.National Institutes of Health.
32 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014948)
33 ClinicalTrials.gov (NCT05108922) A Phase 3, Open-Label, Parallel-Group, 2-Arm Study to Investigate Amyloid Plaque Clearance With Donanemab Compared With Aducanumab-avwa in Participants With Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
34 ClinicalTrials.gov (NCT02004392) Study of the Safety and Clinical Effects of 2 Doses of EVP-6124 in Subjects With Alzheimer's Disease Who Complete Study EVP-6124-024 or EVP-6124-025. U.S. National Institutes of Health.
35 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6933).
36 ClinicalTrials.gov (NCT01245530) An Efficacy and Safety Study of INM-176 for the Treatment of Patients With Alzheimer Type Dementia. U.S. National Institutes of Health.
37 ClinicalTrials.gov (NCT00528112) Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study. U.S. National Institutes of Health.
38 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034429)
39 ClinicalTrials.gov (NCT01960010) A Safety and Efficacy Study of MIM-D3 Ophthalmic Solution for the Treatment of Dry Eye. U.S. National Institutes of Health.
40 ClinicalTrials.gov (NCT04669028) A Phase 3, Double Blind, Randomized, Placebo Controlled, Parallel Group, Multicenter Study of NE3107 in Subjects Who Have Mild to Moderate Probable Alzheimer's Disease. U.S.National Institutes of Health.
41 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8325).
42 ClinicalTrials.gov (NCT05463731) Assessment of Safety, Tolerability, and Efficacy Measured by Amyloid Reduction of LY3372993 in Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
43 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
44 Clinical pipeline report, company report or official report of SEIKAGAKU.
45 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6932).
46 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2648).
47 ClinicalTrials.gov (NCT00262821) Cisplatin and Radiation Therapy With or Without Tirapazamine in Treating Patients With Cervical Cancer. U.S. National Institutes of Health.
48 ClinicalTrials.gov (NCT00314912) Open-Label Extension of the Phase III Study With Tramiprosate (3APS) in Patients With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
49 ClinicalTrials.gov (NCT01689246) Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
50 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001601)
51 ClinicalTrials.gov (NCT03823404) GAIN Trial: A Randomized, Double-Blind, Placebo-Controlled Study of COR388 in Subjects With Alzheimer's Disease. U.S.National Institutes of Health.
52 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7789).
53 ClinicalTrials.gov (NCT02565511) A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease.
54 ClinicalTrials.gov (NCT02565511) A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease (Generation S1). U.S. National Institutes of Health.
55 ClinicalTrials.gov (NCT05269394) A Phase II/III Multicenter Randomized, Double-Blind, Placebo-Controlled Platform Trial of Potential Disease Modifying Therapies Utilizing Biomarker, Cognitive, and Clinical Endpoints in Dominantly Inherited Alzheimer's Disease. U.S.National Institutes of Health.
56 ClinicalTrials.gov (NCT04886063) Open-Label Extension of Studies ATH-1017-AD-0201 and ATH-1017-AD-0202 in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
57 ClinicalTrials.gov (NCT03090516) Clinical Study on Improving the Cognitive Function of Patients With Mild to Moderate Alzheimer's Disease by Using Ginkgo Biloba Dispersible Tablets. U.S.National Institutes of Health.
58 ClinicalTrials.gov (NCT02719327) Impact of Icosapent Ethyl on Alzheimers Disease Biomarkers in Preclinical Adults. U.S.National Institutes of Health.
59 ClinicalTrials.gov (NCT02569398) An Efficacy and Safety Study of JNJ-54861911 in Participants Who Are Asymptomatic at Risk for Developing Alzheimer's Dementia.
60 ClinicalTrials.gov (NCT01554956) Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients. U.S. National Institutes of Health.
61 ClinicalTrials.gov (NCT02205840) A Clinical Study Evaluating the Safety and Efficacy of SI-614 Ophthalmic Solution in Patients With Dry Eye.. U.S. National Institutes of Health.
62 ClinicalTrials.gov (NCT02579252) 24 Months Safety and Efficacy Study of AADvac1 in Patients With Mild Alzheimer's Disease (ADAMANT). U.S. National Institutes of Health.
63 ClinicalTrials.gov (NCT03712787) An Extension Study of ABBV-8E12 in Early Alzheimer's Disease (AD). U.S. National Institutes of Health.
64 ClinicalTrials.gov (NCT05291234) A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of ABBV-916 in Subjects With Early Alzheimer's Disease. U.S.National Institutes of Health.
65 ClinicalTrials.gov (NCT01655680) A Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia. U.S. National Institutes of Health.
66 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6927).
67 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7357).
68 ClinicalTrials.gov (NCT03461276) A Multi-center, Randomized, Double-blind, Placebo-controlled, 24 Months Study in Patients With Amnestic Mild Cognitive Impairment or Very Mild Alzheimer's Disease to Investigate the Safety, Tolerability and Immune Response of Repeated Subcutaneous Injections of ABvac40. U.S.National Institutes of Health.
69 ClinicalTrials.gov (NCT03790982) A Randomized, Double Blind, Placebo Controlled, Parallel-Group 52-week Multicenter Phase II Study to Investigate the Safety, Efficacy and Pharmacokinetics of AD-35 Tablet in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
70 Clinical pipeline report, company report or official report of Affiris.
71 ClinicalTrials.gov (NCT04592874) A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease. U.S.National Institutes of Health.
72 ClinicalTrials.gov (NCT00021723) Randomized Safety, Tolerability and Pilot Efficacy of AN-1792 in Alzheimer's Disease. U.S. National Institutes of Health.
73 ClinicalTrials.gov (NCT03806478) Safety, Tolerability and Efficacy Assessment of Intranasal Nanoparticles of APH-1105, A Novel Alpha Secretase Modulator For Mild to Moderate Cognitive Impairment Due to Alzheimer's Disease(AD). U.S.National Institutes of Health.
74 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7371).
75 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030006)
76 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031585)
77 ClinicalTrials.gov (NCT01012375) Study to Investigate the Efficacy and Tolerability of AZD1446 in Adult ADHD Patients.. U.S. National Institutes of Health.
78 ClinicalTrials.gov (NCT01548287) A Study of the Safety and Tolerability of AZD5213 Effect on Sleep for Patients With Alzheimer's/Cognitive Impairment. U.S. National Institutes of Health.
79 ClinicalTrials.gov (NCT00991419) To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden. U.S. National Institutes of Health.
80 ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
81 ClinicalTrials.gov (NCT02292238) Benfotiamine in Alzheimer's Disease: A Pilot Study. U.S.National Institutes of Health.
82 ClinicalTrials.gov (NCT04867616) A Patient- and Investigator-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Bepranemab (UCB0107) in Study Participants With Prodromal to Mild Alzheimer's Disease (AD), Followed by an Open-Label Extension Period. U.S.National Institutes of Health.
83 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6489).
84 ClinicalTrials.gov (NCT03817684) Tetra PICASSO AD Trial: Study to Evaluate Effects of BPN14770 in Early Alzheimer's Subjects. U.S. National Institutes of Health.
85 ClinicalTrials.gov (NCT03560245) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study Assessing the Safety, Tolerability and Efficacy of Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease Subjects Not Receiving Memantine Treatment. U.S.National Institutes of Health.
86 ClinicalTrials.gov (NCT00876863) Randomized, Controlled Study Evaluating CERE-110 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
87 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7339).
88 ClinicalTrials.gov (NCT00621270) Safety and Effectiveness Study of BCI-540 Versus Placebo in the Treatment of Major Depressive Disorder With Concomitant Anxiety. U.S. National Institutes of Health.
89 ClinicalTrials.gov (NCT02185053) A Phase II Study of CPC-201 to Treat Alzheimer's Disease Type Dementia. U.S. National Institutes of Health.
90 ClinicalTrials.gov (NCT04735536) Pilot Clinical Study of CT1812 in Mild to Moderate Alzheimer's Disease Using EEG. U.S. National Institutes of Health.
91 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7842).
92 ClinicalTrials.gov (NCT04798989) A Phase 2a Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CY6463 When Administered to Participants With Alzheimer's Disease and Vascular Pathology. U.S.National Institutes of Health.
93 ClinicalTrials.gov (NCT00154635) Efficacy and Safety Study of DCB-AD1 in Patients With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
94 ClinicalTrials.gov (NCT03055741) A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase IIb, Clinical Study to Evaluate the Safety and Efficacy of DHP1401 in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil(DRAMA). U.S.National Institutes of Health.
95 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030024)
96 ClinicalTrials.gov (NCT01661673) Safety, Tolerability, Pharmacokinetics of EVP-0962 and Effects of EVP-0962 on Cerebral Spinal Fluid Amyloid Concentrations in Healthy Subjects and in Subjects With Mild Cognitive Impairment or Early Alzheimer's Disease. U.S. National Institutes of Health.
97 ClinicalTrials.gov (NCT00087724) A Randomized Study to Evaluate FK962 in Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
98 Clinical pipeline report, company report or official report of Forum pharmaceuticals.
99 ClinicalTrials.gov (NCT01221246) Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours. U.S. National Institutes of Health.
100 ClinicalTrials.gov (NCT01772199) Study to Assess Whether GSK239512 Can Remyelinate Lesions in Subjects With Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
101 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027328)
102 ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health.
103 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
104 ClinicalTrials.gov (NCT03363269) A Multi-center, Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Evaluate the Efficacy and Safety of ID1201 for Dose-finding in Mild Alzheimer's Disease. U.S.National Institutes of Health.
105 Inhibition of I B phosphorylation prevents load-induced cardiac dysfunction in mice. Am J Physiol Heart Circ Physiol. 2012 Dec 15;303(12):H1435-45.
106 ClinicalTrials.gov (NCT04619420) A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's Disease. U.S.National Institutes of Health.
107 Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment. Curr Drug Targets. 2012 Apr;13(4):483-94.
108 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6475).
109 ClinicalTrials.gov (NCT03367403) A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ). U.S. National Institutes of Health.
110 ClinicalTrials.gov (NCT05063539) Assessment of Safety, Tolerability, and Efficacy of LY3372689 in Early Symptomatic Alzheimer's Disease. U.S.National Institutes of Health.
111 Amarantus BioScience Licenses LymPro Alzheimer's Disease Diagnostic Blood Test
112 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033430)
113 ClinicalTrials.gov (NCT00843518) Treatment for Aggression and Agitation in Patients With Alzheimer's Disease. U.S. National Institutes of Health.
114 Clinical pipeline report, company report or official report of Meta-IQ Aps.
115 Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS). J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Sep 1;878(25):2348-52.
116 ClinicalTrials.gov (NCT05602727) A Phase 2a/2b Randomized, Placebo-Controlled Clinical Study To Evaluate The Safety And Efficacy Of MK-1942 As Adjunctive Therapy In Participants With Mild To Moderate Alzheimer's Disease Dementia. U.S.National Institutes of Health.
117 ClinicalTrials.gov (NCT01852110) Efficacy and Safety of MK-7622 as Adjunct Therapy in Participants With Alzheimer's Disease (MK-7622-012). U.S. National Institutes of Health.
118 ClinicalTrials.gov (NCT03038035) The Alzheimer's Disease THErapy With NEuroaid (ATHENE) Study : Assessing the Safety and Efficacy of Neuroaid II (MLC901) in Patients With Mild to Moderate Alzheimer's Disease Stable on Cholinesterase Inhibitors or Memantine: A Randomized, Double Blind, Placebo Controlled Trial. U.S.National Institutes of Health.
119 ClinicalTrials.gov (NCT03044249) A Study of MP-101 in Dementia-Related Psychosis and/or Agitation and Aggression. U.S. National Institutes of Health.
120 ClinicalTrials.gov (NCT05194163) A Phase 2a Study of MW150 Stress Kinase Inhibitor in Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
121 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006456)
122 ClinicalTrials.gov (NCT00001933) Nefiracetam in the Treatment of Alzheimer's Disease. U.S. National Institutes of Health.
123 ClinicalTrials.gov (NCT01928420) A Single Site, Randomized, Double-blind, Placebo Controlled Trial of NIC5-15 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
124 Clinical pipeline report, company report or official report of Neuraly
125 ClinicalTrials.gov (NCT02035553) A Study of the Safety and Efficacy of Pimavanserin in Patients With Alzheimer's Disease Psychosis. U.S. National Institutes of Health.
126 ClinicalTrials.gov (NCT02471196) Efficacy of ORM-12741 on Agitation/Aggression Symptoms in Alzheimer's Disease.
127 ClinicalTrials.gov (NCT03867253) A Multicentre,Randomised, Double-blind, Placebo-controlled, 3-arm, 24-week Parallel-group Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of ORY-2001 in Patients With Mild-moderate Alzheimer's Disease. U.S.National Institutes of Health.
128 ClinicalTrials.gov (NCT01590888) Effect of PBT2 in Patients With Early to Mid Stage Huntington Disease. U.S. National Institutes of Health.
129 ClinicalTrials.gov (NCT01712074) Study Evaluating TheSafety And Efficacy Of PF-05212377 Or Placebo In Subjects With Alzheimer's Disease With Existing Neuropsychiatric Symptoms On Donepezil. U.S. National Institutes of Health.
130 ClinicalTrials.gov (NCT00930059) A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease. U.S. National Institutes of Health.
131 ClinicalTrials.gov (NCT01821118) Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy. U.S. National Institutes of Health.
132 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021864)
133 ClinicalTrials.gov (NCT04388254) Simufilam (PTI-125), 100 mg, for Mild-to-moderate Alzheimer's Disease Patients (PTI-125). U.S. National Institutes of Health.
134 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021506)
135 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026046)
136 ClinicalTrials.gov (NCT03289143) A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease. U.S. National Institutes of Health.
137 ClinicalTrials.gov (NCT03462121) A 6-Month, Double-Blind, Phase 2 Study and 6-Month Open- Label Extension Evaluating the Safety, Tolerability, and Clinical Benefit of RPh201 in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease. U.S.National Institutes of Health.
138 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032202)
139 ClinicalTrials.gov (NCT04602624) An Open-Label Evaluation of the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
140 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7356).
141 ClinicalTrials.gov (NCT01266525) Effect of Different Doses of SAR110894D on Cognition in Patients With Mild to Moderate Alzheimer's Disease on Donepezil. U.S. National Institutes of Health.
142 ClinicalTrials.gov (NCT03828747) A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study of MTAU9937A in Patients With Moderate Alzheimer's Disease. U.S.National Institutes of Health.
143 ClinicalTrials.gov (NCT00842673) Preliminary Efficacy and Safety Study of ST101 in Alzheimer's Disease. U.S. National Institutes of Health.
144 ClinicalTrials.gov (NCT02258152) SYN120 a Dual 5-HT6/5-HT2A Antagonist Proof of Concept Study to Evaluate Its Safety, Tolerability and Efficacy in Parkinson's Disease Dementia (SYNAPSE). U.S. National Institutes of Health.
145 ClinicalTrials.gov (NCT02079909) Efficacy and Safety of T-817MA in Patients With Mild to Moderate Alzheimer's Disease (US202). U.S. National Institutes of Health.
146 ClinicalTrials.gov (NCT04251182) A Randomized, Double-Blind, Placebo-Controlled Multi-Center Study to Evaluate the Safety and Efficacy of Three Dose Strengths of T3D-959 in Subjects With Mild-to-Moderate Alzheimer's Disease. U.S.National Institutes of Health.
147 ClinicalTrials.gov (NCT02414347) F 18 T807 Tau PET Imaging of Alzheimer's Disease. U.S. National Institutes of Health.
148 ClinicalTrials.gov (NCT05476783) A Multi-center Open-label Long Term Extension Study to Assess the Safety of TB006 in Patients Who Have Completed Protocol TB006AD2102 and in De Novo Patients With Alzheimer's Disease. U.S.National Institutes of Health.
149 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8426).
150 A Phase II Trial of Tideglusib in Alzheimer's Disease. J Alzheimers Dis. 2015;45(1):75-88.
151 ClinicalTrials.gov (NCT01966666) A Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of TPI-287 in Alzheimer's Disease. U.S. National Institutes of Health.
152 Clinical pipeline report, company report or official report of Roche
153 Biopharmaceutical Research Companies are Developing Nearly 100 Medicines for Alzheimer's Disease and Other Dementias. Pharmaceutical Research and Manufacturers of America report. 2012.
154 ClinicalTrials.gov (NCT02551809) Evaluate the Safety, Tolerability, Immunogenicity and Efficacy of UB-311 in Mild Alzheimer's Disease (AD) Patients.
155 ClinicalTrials.gov (NCT01284387) Amyloid Imaging And Safety Study Of ACC-001 In Subjects With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
156 ClinicalTrials.gov (NCT01428362) VI-1121 for the Treatment Alzheimer's Disease. U.S. National Institutes of Health.
157 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031074)
158 ClinicalTrials.gov (NCT05363293) A Multiple-dose, Steady-state, Double-blind, Ascending Dose, Safety, Tolerability, Pharmacokinetic Study of AL001 in Patients With Mild to Moderate Alzheimer\'s Disease and Healthy Adult Subjects ("MAD Study"). U.S.National Institutes of Health.
159 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030376)
160 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).
161 ClinicalTrials.gov (NCT03865017) A Safety and Tolerability Study of GB301 Given as a Single Intravenous Dose in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
162 ClinicalTrials.gov (NCT03069014) Study of LM11A-31-BHS in Mild-moderate AD Patients. U.S. National Institutes of Health.
163 ClinicalTrials.gov (NCT03634007) A 52-Week, Multicenter, Phase 1/2 Open-label Study to Evaluate the Safety of LX1001 in Participants With APOE4 Homozygote Alzheimer's Disease. U.S.National Institutes of Health.
164 ClinicalTrials.gov (NCT05040321) A Proof of Concept Trial of a Sirtuin-NAD Activator in Alzheimer's Disease. U.S.National Institutes of Health.
165 MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.
166 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7034).
167 ClinicalTrials.gov (NCT04445831) A Phase Ib/IIa Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Immunogenicity of Different Doses, Regimens and Combinations of Tau Targeted Vaccines in Subjects With Early Alzheimer's Disease. U.S.National Institutes of Health.
168 ClinicalTrials.gov (NCT04249869) The Effect of Traditional Chinese Medicine (VGH-AD1) on Patients With Alzheimer's Disease: A Double-blinded Randomized Placebo-controlled Cross-over Study. U.S.National Institutes of Health.
169 ClinicalTrials.gov (NCT01609257) Norovirus Bivalent-Vaccine Efficacy Study. U.S. National Institutes of Health.
170 ClinicalTrials.gov (NCT04983368) XanaMIA-DR A Double-Blind, Placebo-Controlled, Dose Ranging Study to Assess the Efficacy, Pharmacodynamics and Safety of Xanamem? in Healthy Elderly Volunteers. U.S.National Institutes of Health.
171 List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegener Dis. 2012;9(4):210-83.
172 ClinicalTrials.gov (NCT00838877) Positron Emission Tomography (PET) Study With [18F]AZD4694 and [11C]AZD2184, Candidate PET Ligands for A Amyloid. U.S. National Institutes of Health.
173 ClinicalTrials.gov (NCT00870519) Brain Imaging Study in Subjects With Alzheimer Disease in Comparison to Healthy Subjects. U.S. National Institutes of Health.
174 ClinicalTrials.gov (NCT00657813) Evaluation of [123I] MNI-330 and SPECT as a Marker of Beta-amyloid Protein Deposition. U.S. National Institutes of Health.
175 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031827)
176 ClinicalTrials.gov (NCT01369225) Open Label Extension Study Evaluating Safety and Tolerability of AAB-003 (PF-05236812) in Subject With Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
177 Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
178 ClinicalTrials.gov (NCT04133649) Evaluation of Safety and Tolerability of Libella Gene Therapy (LGT) for the Treatment of Aging: AAV- hTERT. U.S.National Institutes of Health.
179 ClinicalTrials.gov (NCT01908010) Safety, Tolerability, and Pharmacokinetics of ABT-354 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors. U.S. National Institutes of Health.
180 ClinicalTrials.gov (NCT02220738) Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors. U.S. National Institutes of Health.
181 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
182 ClinicalTrials.gov (NCT04931459) A Phase 1 Placebo-Controlled, Single- and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of Intravenous ACU193 in Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
183 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033932)
184 ClinicalTrials.gov (NCT01397539) A Randomized, Blinded, Placebo-Controlled Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB037 in Subjects With Mild to Moderate Alzheimer's Disease. U.S.National Institutes of Health.
185 ClinicalTrials.gov (NCT00495417) Tolerability and Safety of Subcutaneous Administration of Affitope AD01 in Mild to Moderate Alzheimer's Disease. U.S. National Institutes of Health.
186 ClinicalTrials.gov (NCT03822208) A Phase I Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Single and Multiple Doses of AL003 in Healthy Participants and in Participants With Mild to Moderate Alzheimer's Disease.. U.S.National Institutes of Health.
187 ClinicalTrials.gov (NCT00739037) Study Evaluating PAZ-417 in Cerebrospinal Fluid in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
188 ClinicalTrials.gov (NCT05231785) A Randomized, Double-blind, Placebo-controlled Single Ascending Dose and Open-label Multi-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-APP in Adult Patients With Early-onset Alzheimer's Disease (EOAD). U.S.National Institutes of Health.
189 ClinicalTrials.gov (NCT01837641) A Study of LY3002813 in Participants With Alzheimer's Disease. U.S. National Institutes of Health.
190 Clinical pipeline report, company report or official report of Annovis Bio
191 Clinical pipeline report, company report or official report of Aphios
192 ClinicalTrials.gov (NCT05344989) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of APNmAb005 in Healthy Subjects. U.S.National Institutes of Health.
193 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031729)
194 ClinicalTrials.gov (NCT04759365) A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Oral ASN51 in Healthy Young Adult and Elderly Subjects and Elderly Subjects With Alzheimer's Disease. U.S.National Institutes of Health.
195 ClinicalTrials.gov (NCT01406145) A Study of the Safety and Tolerability of ASP0777 in Subjects With Alzheimer's Disease (AD) Taking a Stable Dose of Donepezil. U.S. National Institutes of Health.
196 Clinical pipeline report, company report or official report of Astellas Pharma.
197 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025412)
198 5HT6 Antagonists in the Treatment of Alzheimer's Dementia: Current Progress. Neurol Ther. 2018 Jun;7(1):51-58.
199 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6931).
200 ClinicalTrials.gov (NCT00692705) Positron Emission Tomography (PET) Study With [11C]AZD2995 and [11C]AZD2184, Candidate PET Ligands for Amyloid. U.S. National Institutes of Health.
201 ClinicalTrials.gov (NCT01153607) Evaluation of the Diagnostic Potential of BAY1006578 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of BAY1006578 in Healthy Volunteers. U.S. National Institutes of Health.
202 ClinicalTrials.gov (NCT01548703) A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers. U.S. National Institutes of Health.
203 ClinicalTrials.gov (NCT01546051) A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers. U.S. National Institutes of Health.
204 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6979).
205 ClinicalTrials.gov (NCT04476303) A Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of BEY2153 After Oral Administration in Healthy Young and Elderly Male Volunteers. U.S.National Institutes of Health.
206 ClinicalTrials.gov (NCT05195008) A Phase 1 Randomized, Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics, With an Open-Label Target Occupancy Study of BIIB113 in Healthy Participants. U.S.National Institutes of Health.
207 ClinicalTrials.gov (NCT01492374) Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease. U.S. National Institutes of Health.
208 ClinicalTrials.gov (NCT05804383) A Phase 1B Multiple Ascending Dose Study of The Safety and Tolerability of BMS-984923 in Healthy Older Adults and Patients With Alzheimer's Disease. U.S.National Institutes of Health.
209 ClinicalTrials.gov (NCT04920903) A Phase 1, Randomized, Double-Blind, Placebo-Controlled, First-in-Human, Single- and Multiple-Ascending Dose Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Oral COR588 in Healthy Adult Subjects. U.S.National Institutes of Health.
210 ClinicalTrials.gov (NCT00621010) Safety Study of CTS21166 to Treat Alzheimer Disease. U.S. National Institutes of Health.
211 DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers. Clin Pharmacol Ther. 2020 Feb;107(2):406-414.
212 ClinicalTrials.gov (NCT03757325) Study to Evaluate DNL747 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
213 ClinicalTrials.gov (NCT05450549) A Phase 1, Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL919 in Healthy Participants. U.S.National Institutes of Health.
214 ClinicalTrials.gov (NCT01042106) Safety, Pharmacokinetics and Pharmacodynamics of DSP-8658 in Patients With Type 2 Diabetes Mellitus and Healthy Adults. U.S. National Institutes of Health.
215 ClinicalTrials.gov (NCT01522586) Clinical Trial to Investigate the Safety, Tolerability, and Pharmacokinetics of DWP09031. U.S. National Institutes of Health.
216 ClinicalTrials.gov (NCT01221259) A Randomized, Double-blind, Placebo-controlled, Sequential Ascending, Single-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2212 in Healthy Subjects. U.S. National Institutes of Health.
217 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7358).
218 Clinical pipeline report, company report or official report of Eisai
219 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 700036191)
220 An NCAM mimetic, FGL, alters hippocampal cellular morphometry in young adult (4 month-old) rats. Neurochem Res. 2013 Jun;38(6):1208-18.
221 ClinicalTrials.gov (NCT00719394) Study Evaluating Safety of GSI 136 in Young and Elderly Japanese Males. U.S. National Institutes of Health.
222 ClinicalTrials.gov (NCT01924858) A Positron Emission Tomography (PET) Study to Investigate the Brain Biodistribution of 18F GSK2647544 in Healthy Subjects to Determine Its Ability to Cross the Blood-brain-barrier.. U.S. National Institutes of Health.
223 ClinicalTrials.gov (NCT01702480) Effects of Triglycerides on Age-Related Cognitive Function Decline in Older Subjects. U.S. National Institutes of Health.
224 ClinicalTrials.gov (NCT01482013) Safety Study of HPP854 in Subjects With Mild Cognitive Impairment or a Diagnosis of Mild Alzheimer's Disease. U.S. National Institutes of Health.
225 ClinicalTrials.gov (NCT04749563) A Phase I Randomized Placebo Controlled MAD Study to Evaluate Safety and Tolerability of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease. U.S.National Institutes of Health.
226 ClinicalTrials.gov (NCT03838185) A Phase I, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety, Tolerability and Pharmacokinetics of Single Ascending Oral Doses of J147 in Healthy Young Volunteers and Healthy Elderly Volunteers. U.S.National Institutes of Health.
227 Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
228 ClinicalTrials.gov (NCT04149860) Interventional, Randomized, Double-blind, Placebo-controlled, Single-ascending-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Lu AF87908 in Healthy Subjects and Patients With Alzheimer's Disease. U.S.National Institutes of Health.
229 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6936).
230 ClinicalTrials.gov (NCT04451408) A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3372993 in Participants With Alzheimer's Disease and Healthy Participants. U.S.National Institutes of Health.
231 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009639)
232 Biopharmaceutical Research Companies Are Developing More Than 430 Medicines for Top Chronic Diseases Affecting Older Americans. Pharmaceutical Research and Manufacturers of America report. 2014.
233 ClinicalTrials.gov (NCT00954538) Safety, Radiation Dosimetry, Biokinetics, and Effectiveness of [18F]MK3328 (MK-3328-001). U.S. National Institutes of Health.
234 ClinicalTrials.gov (NCT03740178) A Randomized, Double-Blinded Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of MK-4334 in Participants With Alzheimer's Clinical Syndrome on a Stable Dose of Donepezil. U.S.National Institutes of Health.
235 ClinicalTrials.gov (NCT04074837) Phase1a, Randomized Placebo-controlled, Single and Multiple Dose, Dose-escalation Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Oral NNI-362 in Healthy Aged Volunteers 50 to 72 Years of Age. U.S.National Institutes of Health.
236 ClinicalTrials.gov (NCT01163825) Encapsulated Cell Biodelivery of Nerve Growth Factor to Alzheimer Disease Patients. U.S. National Institutes of Health.
237 Clinical pipeline report, company report or official report of NeuroTherapia
238 Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res. 2008 Nov 15;68(22):9551-7.
239 ClinicalTrials.gov (NCT01193062) Study In Healthy Subjects To Evaluate The Changes In The Protein sAPP-Alpha In Cerebrospinal Fluid Following A Single Oral Dose Of PF-04995274. U.S. National Institutes of Health.
240 ClinicalTrials.gov (NCT02407353) A Study to Evaluate the Pharmacodynamic Effects of Single Oral Doses of PF-06648671 on beta-Amyloid (Abeta) Concentrations in Cerebrospinal Fluid (CSF). U.S. National Institutes of Health.
241 The Anticholinesterase Phenserine and Its Enantiomer Posiphen as 5 ntranslated-Region-Directed Translation Blockers of the Parkinson's Alpha Synuclein Expression. Parkinson's Disease Volume 2012 (2012), Article ID 142372, Page(13).
242 ClinicalTrials.gov (NCT00744146) First Time in Human Study of Protexia. U.S. National Institutes of Health.
243 Clinical pipeline report, company report or official report of I-Mab Biopharma
244 Clinical pipeline report, company report or official report of Prothena
245 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028705)
246 ClinicalTrials.gov (NCT04672135) A Phase 1 (First in Human) Randomized, Double-blind, Placebo-controlled SAD, MAD Study With an Adaptive Dose Design to Evaluate the Safety, Tolerability, and Pharmacokinetics of REM0046127 in Healthy Subjects. U.S.National Institutes of Health.
247 Clinical pipeline report, company report or official report of Genentch
248 ClinicalTrials.gov (NCT01592331) A Pharmacodynamic and Pharmacokinetic Study of RO5508887 in Healthy Volunteers. U.S. National Institutes of Health.
249 ClinicalTrials.gov (NCT01485302) Single and Repeated Dosing Study to Assess the Safety and the Concentration-time Profile of SAR228810 in Alzheimer's Patients. U.S. National Institutes of Health.
250 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036473)
251 ClinicalTrials.gov (NCT04973189) A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Intravenous Administration of SHR-1707 in Healthy Young Adult and Elderly Subjects. U.S.National Institutes of Health.
252 ClinicalTrials.gov (NCT01560884) Study to Assess the Safety and the Phosphate Binding Capacity of Renazorb. U.S. National Institutes of Health.
253 ClinicalTrials.gov (NCT01357421) Effects of TT301 on Cytokine Levels Post Endotoxin Challenge. U.S. National Institutes of Health.
254 ClinicalTrials.gov (NCT01548430) A Safety Study of TTP4000 in Subjects With Alzheimer's Disease. U.S. National Institutes of Health.
255 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027767)
256 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021230)
257 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6549).
258 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1959).
259 The role of the innate immune system in psychiatric disorders. Mol Cell Neurosci. 2013 Mar;53:52-62.
260 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6553).
261 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
262 Gamma secretase inhibitors: a patent review (2013 - 2015).Expert Opin Ther Pat. 2017 Jul;27(7):851-866.
263 Progress in the development of histamine H3 receptor antagonists/inverse agonists: a patent review (2013-2017).Expert Opin Ther Pat. 2018 Mar;28(3):175-196.
264 MAO inhibitors and their wider applications: a patent review.Expert Opin Ther Pat. 2018 Mar;28(3):211-226.
265 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.
266 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021875)
267 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004496)
268 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004036)
269 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029150)
270 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031584)
271 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7697).
272 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009278)
273 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003027)
274 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011083)
275 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011312)
276 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4304).
277 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009631)
278 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001956)
279 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7819).
280 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020415)
281 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024230)
282 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009546)
283 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028783)
284 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030748)
285 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012921)
286 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028311)
287 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033289)
288 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017461)
289 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024936)
290 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025887)
291 2011 Pipeline of Anavex.
292 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023654)
293 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013391)
294 ClinicalTrials.gov (NCT03431844) Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac Operation. U.S. National Institutes of Health.
295 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023984)
296 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021196)
297 Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
298 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015422)
299 Clinical trials with pegylated liposomal Doxorubicin in the treatment of ovarian cancer. J Drug Deliv. 2013;2013:898146.
300 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001856)
301 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007119)
302 In vivo muscarinic cholinergic mediated effects of Lu 25-109, a M1 agonist and M2/M3 antagonist in vitro. Psychopharmacology (Berl). 1998 Jun;137(3):233-40.
303 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8478).
304 Therapeutic potential of CNS-active M2 antagonists: novel structures and pharmacology. Life Sci. 1993;52(5-6):497-503.
305 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002066)
306 4-(O-benzylphenoxy)-N-methylbutylamine (bifemelane) and other 4-(O-benzylphenoxy)-N-methylalkylamines as new inhibitors of type A and B monoamine oxidase. J Neurochem. 1988 Jan;50(1):243-7.
307 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005173)
308 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006555)
309 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003560)
310 PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106.
311 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020178)
312 Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem. 2007 Dec 7;282(49):35666-78.
313 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019997)
314 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004498)
315 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001380)
316 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006757)
317 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001957)
318 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004819)
319 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4210).
320 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4219).
321 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003218)
322 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692)
323 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006922)
324 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007171)
325 Milacemide, the selective substrate and enzyme-activated specific inhibitor of monoamine oxidase B, increases dopamine but not serotonin in caudate nucleus of rhesus monkey. Neurochem Int. 1990;17(2):325-9.
326 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000658)
327 Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol. 2005 Jun;25(3-4):513-52.
328 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017551)
329 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005356)
330 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005353)
331 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017252)
332 A novel acetylcholinesterase inhibitor, Ro 46-5934, which interacts with muscarinic M2 receptors. Biochem Soc Trans. 1994 Aug;22(3):755-8.
333 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000634)
334 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007561)
335 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001729)
336 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029796)
337 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 350).
338 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004137)
339 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000565)
340 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005755)
341 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000552)
342 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4347).
343 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
344 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7530).
345 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 468).
346 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7337).
347 Novel -secretase enzyme modulators directly target presenilin protein. J Biol Chem. 2011 Oct 28;286(43):37181-6
348 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5015).
349 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 59).
350 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
351 Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.ACS Omega. 2019 Oct 2;4(16):16943-16955. doi: 10.1021/acsomega.9b02307. eCollection 2019 Oct 15.
352 Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease.Neurobiol Dis. 2020 Feb;134:104644. doi: 10.1016/j.nbd.2019.104644. Epub 2019 Oct 24.
353 Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.Clin Epigenetics. 2019 Mar 21;11(1):52. doi: 10.1186/s13148-019-0636-y.
354 Serum Adiponectin is Related to Dementia.J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):779-783. doi: 10.1093/gerona/glz102.
355 Significant enhanced expressions of aquaporin-1, -4 and -9 in the brains of various prion diseases.Prion. 2019 Jan;13(1):173-184. doi: 10.1080/19336896.2019.1660487.
356 Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.Neurobiol Dis. 2019 May;125:176-189. doi: 10.1016/j.nbd.2019.02.003. Epub 2019 Feb 6.
357 C5a Increases the Injury to Primary Neurons Elicited by Fibrillar Amyloid Beta.ASN Neuro. 2017 Feb;9(1):1759091416687871. doi: 10.1177/1759091416687871.
358 Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications.Front Pharmacol. 2019 Oct 28;10:1282. doi: 10.3389/fphar.2019.01282. eCollection 2019.
359 Alteration in memory cognition due to activation of caveolin-1 and oxidative damage in a model of dementia of Alzheimer's type.Indian J Pharmacol. 2019 May-Jun;51(3):173-180. doi: 10.4103/ijp.IJP_81_17.
360 Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline.Neurobiol Aging. 2019 Apr;76:125-132. doi: 10.1016/j.neurobiolaging.2018.12.019. Epub 2019 Jan 7.
361 Inflammatory markers in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review of 170 studies.J Neurol Neurosurg Psychiatry. 2019 May;90(5):590-598. doi: 10.1136/jnnp-2018-319148. Epub 2019 Jan 10.
362 Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.Curr Drug Targets. 2017;18(10):1179-1190. doi: 10.2174/1389450116666151001111826.
363 Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice.PLoS One. 2017 Jul 27;12(7):e0181367. doi: 10.1371/journal.pone.0181367. eCollection 2017.
364 Phosphorylated NF-B subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy.Neurosci Lett. 2019 Jun 21;704:229-235. doi: 10.1016/j.neulet.2019.03.036. Epub 2019 Apr 1.
365 Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.J Neurosci. 2020 Jan 29;40(5):1133-1144. doi: 10.1523/JNEUROSCI.1333-19.2019. Epub 2019 Dec 10.
366 Effect of CYP2D6 and CYP3A4 Genotypes on the Efficacy of Cholinesterase Inhibitors in Southern Chinese Patients With Alzheimer's Disease.Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):302-307. doi: 10.1177/1533317519848237. Epub 2019 May 7.
367 Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene. JCI Insight. 2020 Feb 27;5(4):e135119. doi: 10.1172/jci.insight.135119.
368 The effect of early growth response 1 on levels of Amyloid- 40 peptide in U87MG cells.J Cell Biochem. 2019 Mar;120(3):3514-3519. doi: 10.1002/jcb.27627. Epub 2018 Dec 12.
369 Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.
370 Anxiolytic impact of Apelin-13 in a rat model of Alzheimer's disease: Involvement of glucocorticoid receptor and FKBP5.Peptides. 2019 Aug;118:170102. doi: 10.1016/j.peptides.2019.170102. Epub 2019 Jun 11.
371 VEGF receptor-1 modulates amyloid 1-42 oligomer-induced senescence in brain endothelial cells.FASEB J. 2019 Mar;33(3):4626-4637. doi: 10.1096/fj.201802003R. Epub 2018 Dec 21.
372 Neurofilament Proteins as Prognostic Biomarkers in Neurological Disorders.Curr Pharm Des. 2020;25(43):4560-4569. doi: 10.2174/1381612825666191210154535.
373 Reduced expression of glyoxalase-1 mRNA in mood disorder patients.Neurosci Lett. 2008 Jun 20;438(2):196-9. doi: 10.1016/j.neulet.2008.04.024. Epub 2008 Apr 12.
374 Fighting the Cause of Alzheimer's and GNE Myopathy.Front Neurosci. 2018 Oct 15;12:669. doi: 10.3389/fnins.2018.00669. eCollection 2018.
375 Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer's Disease.Curr Alzheimer Res. 2019;16(10):871-894. doi: 10.2174/1570159X17666190409144558.
376 Curcumin Treatment is Associated with Increased Expression of the N-Methyl-D-Aspartate Receptor (NMDAR) Subunit, NR2A, in a Rat PC12 Cell Line Model of Alzheimer's Disease Treated with the Acetyl Amyloid- Peptide, A(25-35).Med Sci Monit. 2018 May 1;24:2693-2699. doi: 10.12659/MSM.906933.
377 Structure, regulation and related diseases of the actin-binding protein gelsolin.Expert Rev Mol Med. 2019 Jan 30;20:e7. doi: 10.1017/erm.2018.7.
378 Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.Nat Genet. 2019 Mar;51(3):404-413. doi: 10.1038/s41588-018-0311-9. Epub 2019 Jan 7.
379 HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells.J Steroid Biochem Mol Biol. 2018 Sep;182:21-26. doi: 10.1016/j.jsbmb.2018.04.007. Epub 2018 Apr 17.
380 Risk of Late-Onset Alzheimer's Disease by Plasma Cholesterol: Rational In Silico Drug Investigation of Pyrrole-Based HMG-CoA Reductase Inhibitors.Assay Drug Dev Technol. 2017 Oct/Nov;15(7):342-351. doi: 10.1089/adt.2017.804. Epub 2017 Oct 27.
381 No association between histamine N-methyltransferase functional polymorphism Thr105Ile and Alzheimer's disease.Neurosci Lett. 2011 Feb 4;489(2):119-21. doi: 10.1016/j.neulet.2010.11.078. Epub 2010 Dec 5.
382 Prestimulation of Microglia Through TLR4 Pathway Promotes Interferon Beta Expression in a Rat Model of Alzheimer's Disease.J Mol Neurosci. 2019 Apr;67(4):495-503. doi: 10.1007/s12031-018-1249-1. Epub 2019 Jan 4.
383 Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of A Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model.Mol Neurobiol. 2020 Mar;57(3):1473-1483. doi: 10.1007/s12035-019-01827-y. Epub 2019 Nov 23.
384 Overexpression of the Insulin-Like Growth Factor II Receptor Increases -Amyloid Production and Affects Cell Viability.Mol Cell Biol. 2015 Jul;35(14):2368-84. doi: 10.1128/MCB.01338-14. Epub 2015 May 4.
385 Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.Neurology. 2018 Jan 23;90(4):e291-e297. doi: 10.1212/WNL.0000000000004854. Epub 2017 Dec 27.
386 Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.Exp Gerontol. 2019 Jul 1;121:91-98. doi: 10.1016/j.exger.2019.04.003. Epub 2019 Apr 11.
387 Analysis of Surface Levels of IL-1 Receptors and Macrophage Scavenger Receptor I in Peripheral Immune Cells of Patients With Alzheimer Disease.J Geriatr Psychiatry Neurol. 2019 Jul;32(4):211-220. doi: 10.1177/0891988719841728. Epub 2019 Apr 24.
388 Critical Roles of IL-33/ST2 Pathway in Neurological Disorders.Mediators Inflamm. 2018 Feb 4;2018:5346413. doi: 10.1155/2018/5346413. eCollection 2018.
389 Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis.J Cell Sci. 2020 Jan 10;133(5):jcs238030. doi: 10.1242/jcs.238030.
390 Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET.Transl Neurodegener. 2019 Aug 27;8:25. doi: 10.1186/s40035-019-0168-6. eCollection 2019.
391 Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.Exp Neurol. 2020 Feb;324:113115. doi: 10.1016/j.expneurol.2019.113115. Epub 2019 Nov 14.
392 Deep brain stimulation of the nucleus basalis of Meynert attenuates early EEG components associated with defective sensory gating in patients with Alzheimer disease - a two-case study.Eur J Neurosci. 2020 Mar;51(5):1201-1209. doi: 10.1111/ejn.13749. Epub 2017 Nov 22.
393 Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.J Alzheimers Dis. 2020;73(1):135-145. doi: 10.3233/JAD-190991.
394 Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes.Front Neurosci. 2019 Mar 13;13:220. doi: 10.3389/fnins.2019.00220. eCollection 2019.
395 The Role of Neuronal NLRP1 Inflammasome in Alzheimer's Disease: Bringing Neurons into the Neuroinflammation Game.Mol Neurobiol. 2019 Nov;56(11):7741-7753. doi: 10.1007/s12035-019-1638-7. Epub 2019 May 20.
396 Drug likeness, targets, molecular docking and ADMET studies for some indolizine derivatives.Pharmazie. 2018 Nov 1;73(11):635-642. doi: 10.1691/ph.2018.8061.
397 Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing.J Pharmacol Sci. 2018 Jun;137(2):146-153. doi: 10.1016/j.jphs.2018.05.004. Epub 2018 May 29.
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572 CNP and DPYSL2 mRNA expression and promoter methylation levels in brain of Alzheimer's disease patients.J Alzheimers Dis. 2013;33(2):349-55. doi: 10.3233/JAD-2012-121192.
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588 The T9861C Mutation in the mtDNA-Encoded Cytochrome C Oxidase Subunit III Gene Occurs in High Frequency but with Unequal Distribution in the Alzheimer's Disease Brain.J Alzheimers Dis. 2019;72(1):257-269. doi: 10.3233/JAD-190176.
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590 Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia.Front Aging Neurosci. 2017 Aug 9;9:244. doi: 10.3389/fnagi.2017.00244. eCollection 2017.
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596 Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease.FASEB J. 2019 Jan;33(1):231-238. doi: 10.1096/fj.201801001. Epub 2018 Jun 20.
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598 The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice.J Alzheimers Dis. 2017;59(4):1255-1267. doi: 10.3233/JAD-170100.
599 GM6 Attenuates Alzheimer's Disease Pathology in APP Mice.Mol Neurobiol. 2019 Sep;56(9):6386-6396. doi: 10.1007/s12035-019-1517-2. Epub 2019 Feb 23.
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609 Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer's Disease.Front Aging Neurosci. 2018 Mar 6;10:48. doi: 10.3389/fnagi.2018.00048. eCollection 2018.
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652 Role of PTA in the prevention of Cu(amyloid-) induced ROS formation and amyloid- oligomerisation in the presence of Zn.Metallomics. 2019 Jun 19;11(6):1154-1161. doi: 10.1039/c9mt00011a.
653 Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease.J Neurovirol. 2019 Oct;25(5):702-709. doi: 10.1007/s13365-018-0695-4. Epub 2019 Jan 4.
654 A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain.Neuroscience. 2019 Aug 10;413:294-307. doi: 10.1016/j.neuroscience.2019.05.040. Epub 2019 Jun 8.
655 Coagulation factor XIIIa cross-links amyloid into dimers and oligomers and to blood proteins.J Biol Chem. 2019 Jan 11;294(2):390-396. doi: 10.1074/jbc.RA118.005352. Epub 2018 Nov 8.
656 Intron-exon swapping of transglutaminase mRNA and neuronal Tau aggregation in Alzheimer's disease.J Biol Chem. 2001 Feb 2;276(5):3295-301. doi: 10.1074/jbc.M004776200. Epub 2000 Sep 29.
657 Neprilysin Inhibits Coagulation through Proteolytic Inactivation of Fibrinogen.PLoS One. 2016 Jul 20;11(7):e0158114. doi: 10.1371/journal.pone.0158114. eCollection 2016.
658 Regulation of Cell Polarity by PAR-1/MARK Kinase.Curr Top Dev Biol. 2017;123:365-397. doi: 10.1016/bs.ctdb.2016.11.001. Epub 2016 Dec 5.
659 Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation?.Neural Regen Res. 2019 Jul;14(7):1196-1201. doi: 10.4103/1673-5374.251290.
660 Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking throughPACS1.Neurobiol Aging. 2017 Dec;60:129-140. doi: 10.1016/j.neurobiolaging.2017.08.024. Epub 2017 Sep 21.
661 pH-Induced Folding of the Caspase-Cleaved Par-4 Tumor Suppressor: Evidence of Structure Outside of the Coiled Coil Domain.Biomolecules. 2018 Dec 4;8(4):162. doi: 10.3390/biom8040162.
662 Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease.Alzheimers Res Ther. 2018 Sep 25;10(1):98. doi: 10.1186/s13195-018-0426-3.
663 Dietary docosahexaenoic acid supplementation enhances expression of fatty acid-binding protein 5 at the blood-brain barrier and brain docosahexaenoic acid levels.J Neurochem. 2018 Jul;146(2):186-197. doi: 10.1111/jnc.14342.
664 Fas-associated factor 1 and Parkinson's disease.Neurobiol Dis. 2008 Sep;31(3):309-15. doi: 10.1016/j.nbd.2008.05.006. Epub 2008 May 29.
665 The protective role of endogenous n-3 polyunsaturated fatty acids in Tau Alzheimer's disease mouse model.Int J Neurosci. 2019 Apr;129(4):325-336. doi: 10.1080/00207454.2018.1533824. Epub 2018 Nov 2.
666 Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.J Med Chem. 2014 Jul 10;57(13):5764-76. doi: 10.1021/jm500629e. Epub 2014 Jun 23.
667 A multimodal RAGE-specific inhibitor reduces amyloid -mediated brain disorder in a mouse model of Alzheimer disease.J Clin Invest. 2012 Apr;122(4):1377-92. doi: 10.1172/JCI58642. Epub 2012 Mar 12.
668 GW9508 ameliorates cognitive impairment via the cAMP-CREB and JNK pathways in APPswe/PS1dE9 mouse model of Alzheimer's disease.Neuropharmacology. 2020 Mar 1;164:107899. doi: 10.1016/j.neuropharm.2019.107899. Epub 2019 Dec 3.
669 PPARgamma agonists rescue increased phosphorylation of FGF14 at S226 in the Tg2576 mouse model of Alzheimer's disease.Exp Neurol. 2017 Sep;295:1-17. doi: 10.1016/j.expneurol.2017.05.005. Epub 2017 May 15.
670 Fibroblast growth factor 21 ameliorates neurodegeneration in rat and cellular models of Alzheimer's disease.Redox Biol. 2019 Apr;22:101133. doi: 10.1016/j.redox.2019.101133. Epub 2019 Feb 1.
671 FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.J Biosci. 2014 Mar;39(1):85-95. doi: 10.1007/s12038-013-9400-1.
672 Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer's disease.Mol Psychiatry. 2021 Mar;26(3):888-896. doi: 10.1038/s41380-019-0458-5. Epub 2019 Jul 22.
673 N-acetylaspartylglutamate (NAAG) and glutamate carboxypeptidase II: An abundant peptide neurotransmitter-enzyme system with multiple clinical applications.Prog Neurobiol. 2020 Jan;184:101722. doi: 10.1016/j.pneurobio.2019.101722. Epub 2019 Nov 12.
674 Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients.Neurosci Lett. 2008 May 16;436(3):317-20. doi: 10.1016/j.neulet.2008.03.046. Epub 2008 Mar 21.
675 Long Non-coding RNA MALAT1 Inhibits Neuron Apoptosis and Neuroinflammation While Stimulates Neurite Outgrowth and Its Correlation With MiR-125b Mediates PTGS2, CDK5 and FOXQ1 in Alzheimer's Disease.Curr Alzheimer Res. 2019;16(7):596-612. doi: 10.2174/1567205016666190725130134.
676 Influence of variation in the follicle-stimulating hormone receptor gene (FSHR) and age at menopause on the development of Alzheimer's disease in women.Dement Geriatr Cogn Disord. 2011;32(1):63-9. doi: 10.1159/000330472. Epub 2011 Aug 24.
677 Multitarget Drug Design, Molecular Docking and PLIF Studies of Novel Tacrine-Coumarin Hybrids for the Treatment of Alzheimer's Disease.Iran J Pharm Res. 2018 Fall;17(4):1217-1228.
678 FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling.Biochem Biophys Res Commun. 2018 Mar 25;498(1):234-239. doi: 10.1016/j.bbrc.2018.02.201. Epub 2018 Mar 2.
679 Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells.Life Sci. 2019 Mar 15;221:35-46. doi: 10.1016/j.lfs.2019.02.012. Epub 2019 Feb 5.
680 Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease.Eur J Pharmacol. 2018 Jan 5;818:381-399. doi: 10.1016/j.ejphar.2017.11.012. Epub 2017 Nov 11.
681 Early-stage attenuation of phase-amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease.J Neurochem. 2018 Mar;144(5):669-679. doi: 10.1111/jnc.14136. Epub 2017 Oct 10.
682 Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders.Neuropathol Appl Neurobiol. 2020 Apr;46(3):264-278. doi: 10.1111/nan.12577. Epub 2019 Oct 1.
683 Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease.Theranostics. 2019 Apr 12;9(8):2268-2281. doi: 10.7150/thno.30649. eCollection 2019.
684 Potential interaction between the GARS-AIRS-GART Gene and CP2/LBP-1c/LSF transcription factor in Down syndrome-related Alzheimer disease.Cell Mol Neurobiol. 2007 Dec;27(8):1117-26. doi: 10.1007/s10571-007-9217-2. Epub 2007 Sep 28.
685 Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression.Mol Neurobiol. 2019 Sep;56(9):6539-6550. doi: 10.1007/s12035-019-1540-3. Epub 2019 Mar 9.
686 Cognitive decline in Parkinson disease.Nat Rev Neurol. 2017 Apr;13(4):217-231. doi: 10.1038/nrneurol.2017.27. Epub 2017 Mar 3.
687 Effects of Transplanted Umbilical Cord Blood Mononuclear Cells Overexpressing GDNF on Spatial Memory and Hippocampal Synaptic Proteins in a Mouse Model of Alzheimer's Disease.J Alzheimers Dis. 2019;69(2):443-453. doi: 10.3233/JAD-190150.
688 Involvement of Oligodendrocytes in Tau Seeding and Spreading in Tauopathies.Front Aging Neurosci. 2019 May 28;11:112. doi: 10.3389/fnagi.2019.00112. eCollection 2019.
689 Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status?.Int J Endocrinol. 2017;2017:9684061. doi: 10.1155/2017/9684061. Epub 2017 May 30.
690 Disrupted hippocampal growth hormone secretagogue receptor 1 interaction with dopamine receptor D1 plays a role in Alzheimer's disease.Sci Transl Med. 2019 Aug 14;11(505):eaav6278. doi: 10.1126/scitranslmed.aav6278.
691 GLP-1's role in neuroprotection: a systematic review.Brain Inj. 2019;33(6):734-819. doi: 10.1080/02699052.2019.1587000. Epub 2019 Apr 2.
692 Drebrins and Connexins: A Biomedical Perspective.Adv Exp Med Biol. 2017;1006:225-247. doi: 10.1007/978-4-431-56550-5_13.
693 Proteostasis failure and cellular senescence in long-term cultured postmitotic rat neurons.Aging Cell. 2020 Jan;19(1):e13071. doi: 10.1111/acel.13071. Epub 2019 Nov 25.
694 Neuroprotective effects of INT-777 against A(1-42)-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice.Brain Behav Immun. 2018 Oct;73:533-545. doi: 10.1016/j.bbi.2018.06.018. Epub 2018 Jun 20.
695 Oxabicycloheptene Sulfonate Protects Against -Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells.Neurochem Res. 2017 Aug;42(8):2246-2256. doi: 10.1007/s11064-017-2237-5. Epub 2017 Apr 4.
696 Codon 129 polymorphism specific cerebrospinal fluid proteome pattern in sporadic Creutzfeldt-Jakob disease and the implication of glycolytic enzymes in prion-induced pathology.J Proteome Res. 2010 Nov 5;9(11):5646-57. doi: 10.1021/pr1004604. Epub 2010 Oct 13.
697 Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia.Acta Neuropathol Commun. 2018 Oct 19;6(1):108. doi: 10.1186/s40478-018-0612-3.
698 The anti-prion RNA aptamer R12 disrupts the Alzheimer's disease-related complex between prion and amyloid .FEBS J. 2019 Jun;286(12):2355-2365. doi: 10.1111/febs.14819. Epub 2019 Apr 8.
699 APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.Mol Psychiatry. 2016 Jul;21(7):916-24. doi: 10.1038/mp.2015.177. Epub 2015 Dec 1.
700 Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.SLAS Discov. 2020 Mar;25(3):287-298. doi: 10.1177/2472555219875101. Epub 2019 Sep 13.
701 Zinc-mediated Neurotransmission in Alzheimer's Disease: A Potential Role of the GPR39 in Dementia.Curr Neuropharmacol. 2020;18(1):2-13. doi: 10.2174/1570159X17666190704153807.
702 GPR3 and GPR6, novel molecular targets for cannabidiol.Biochem Biophys Res Commun. 2017 Aug 12;490(1):17-21. doi: 10.1016/j.bbrc.2017.05.165. Epub 2017 May 29.
703 Association of GPX1 and GPX4 polymorphisms with episodic memory and Alzheimer's disease.Neurosci Lett. 2018 Feb 14;666:32-37. doi: 10.1016/j.neulet.2017.12.026. Epub 2017 Dec 12.
704 Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario.Dis Model Mech. 2017 May 1;10(5):655-669. doi: 10.1242/dmm.027748. Epub 2017 Mar 30.
705 APP depletion alters selective pre- and post-synaptic proteins.Mol Cell Neurosci. 2019 Mar;95:86-95. doi: 10.1016/j.mcn.2019.02.003. Epub 2019 Feb 11.
706 Collapsin response mediator protein 5 (CRMP5) causes social deficits and accelerates memory loss in an animal model of Alzheimer's disease.Neuropharmacology. 2019 Oct;157:107673. doi: 10.1016/j.neuropharm.2019.107673. Epub 2019 Jun 21.
707 NPTX2 and cognitive dysfunction in Alzheimer's Disease.Elife. 2017 Mar 23;6:e23798. doi: 10.7554/eLife.23798.
708 Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease.J Alzheimers Dis. 2007 Mar;11(1):97-116. doi: 10.3233/jad-2007-11113.
709 Probing the putative 7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.PLoS One. 2017 Dec 20;12(12):e0189513. doi: 10.1371/journal.pone.0189513. eCollection 2017.
710 Unchanged type 1 metabotropic glutamate receptor availability in patients with Alzheimer's disease: A study using (11)C-ITMM positron emission tomography.Neuroimage Clin. 2019;22:101783. doi: 10.1016/j.nicl.2019.101783. Epub 2019 Mar 16.
711 Gender differences in neurotrophin and glutamate receptor expression in cholinergic nucleus basalis neurons during the progression of Alzheimer's disease.J Chem Neuroanat. 2011 Oct;42(2):111-7. doi: 10.1016/j.jchemneu.2011.02.004. Epub 2011 Mar 17.
712 Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.Neuropharmacology. 2017 Sep 1;123:274-286. doi: 10.1016/j.neuropharm.2017.05.008. Epub 2017 May 8.
713 Protein-Protein Interactions and Aggregation Inhibitors in Alzheimer's Disease.Curr Top Med Chem. 2019;19(7):501-533. doi: 10.2174/1568026619666190304153353.
714 Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3.Eur J Med Chem. 2019 Apr 15;168:58-77. doi: 10.1016/j.ejmech.2018.12.063. Epub 2019 Feb 13.
715 Neuroprotective effect of hesperetin and nano-hesperetin on recognition memory impairment and the elevated oxygen stress in rat model of Alzheimer's disease.Biomed Pharmacother. 2018 Jan;97:1096-1101. doi: 10.1016/j.biopha.2017.11.047. Epub 2017 Nov 10.
716 A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer's Disease and MCI Patients: Implications for Regenerative Medicine Approaches.Int J Mol Sci. 2017 Aug 19;18(8):1806. doi: 10.3390/ijms18081806.
717 Systemic hepcidin quantified with LC-MS/MS in dementia in association with disease pathology and severity and with structural changes in the brain.Peptides. 2019 Dec;122:170169. doi: 10.1016/j.peptides.2019.170169. Epub 2019 Sep 26.
718 Novel sulfamate derivatives of menthol: Synthesis, characterization, and cholinesterases and carbonic anhydrase enzymes inhibition properties.Arch Pharm (Weinheim). 2018 Nov;351(11):e1800209. doi: 10.1002/ardp.201800209. Epub 2018 Sep 26.
719 Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease-like neuropathology.Glia. 2018 Dec;66(12):2700-2718. doi: 10.1002/glia.23522. Epub 2018 Sep 12.
720 Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and A generation in Alzheimer's disease.Mol Neurodegener. 2012 Oct 3;7:50. doi: 10.1186/1750-1326-7-50.
721 Positive Association Between Cognitive Function and Cerebrospinal Fluid Orexin A Levels in Alzheimer's Disease.J Alzheimers Dis. 2020;73(1):117-123. doi: 10.3233/JAD-190958.
722 Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease).Curr Alzheimer Res. 2016;13(12):1397-1406. doi: 10.2174/1567205013666160603005630.
723 Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies.Aging (Albany NY). 2018 Oct 20;10(10):2816-2831. doi: 10.18632/aging.101589.
724 Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer's Disease.J Alzheimers Dis. 2018;62(1):115-131. doi: 10.3233/JAD-171032.
725 Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models.Aging Cell. 2020 Jan;19(1):e13081. doi: 10.1111/acel.13081. Epub 2019 Nov 25.
726 Histone Deacetylase Inhibitors as Multitarget Ligands: New Players in Alzheimer's Disease Drug Discovery?.ChemMedChem. 2019 Jun 5;14(11):1067-1073. doi: 10.1002/cmdc.201900174. Epub 2019 May 2.
727 Alterations in the histaminergic system in Alzheimer's disease: a postmortem study.Neurobiol Aging. 2012 Nov;33(11):2585-98. doi: 10.1016/j.neurobiolaging.2011.12.026. Epub 2012 Jan 26.
728 Panax Notoginseng Saponins Ameliorate A-Mediated Neurotoxicity in C. elegans through Antioxidant Activities.Evid Based Complement Alternat Med. 2019 Jun 4;2019:7621043. doi: 10.1155/2019/7621043. eCollection 2019.
729 Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease.Neurosci Lett. 2009 Aug 28;460(2):180-4. doi: 10.1016/j.neulet.2009.05.058. Epub 2009 May 27.
730 Characterization of circRNA-Associated-ceRNA Networks in a Senescence-Accelerated Mouse Prone 8 Brain.Mol Ther. 2017 Sep 6;25(9):2053-2061. doi: 10.1016/j.ymthe.2017.06.009. Epub 2017 Jun 29.
731 HMGCS2 promotes autophagic degradation of the amyloid- precursor protein through ketone body-mediated mechanisms.Biochem Biophys Res Commun. 2017 Apr 29;486(2):492-498. doi: 10.1016/j.bbrc.2017.03.069. Epub 2017 Mar 18.
732 RNA editing alterations in a multi-ethnic Alzheimer disease cohort converge on immune and endocytic molecular pathways.Hum Mol Genet. 2019 Sep 15;28(18):3053-3061. doi: 10.1093/hmg/ddz110.
733 Immunohistochemical study of hnRNP B1 in the postmortem temporal cortices of patients with Alzheimer's disease.Neurosci Res. 2004 Dec;50(4):481-4. doi: 10.1016/j.neures.2004.08.013.
734 GSTM1 Null Genotype and GSTP1 Ile105Val Polymorphism Are Associated with Alzheimer's Disease: a Meta-Analysis.Mol Neurobiol. 2016 Mar;53(2):1355-1364. doi: 10.1007/s12035-015-9092-7. Epub 2015 Jan 30.
735 Heparanase protects the heart against chemical or ischemia/reperfusion injury.J Mol Cell Cardiol. 2019 Jun;131:29-40. doi: 10.1016/j.yjmcc.2019.04.008. Epub 2019 Apr 17.
736 Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.PLoS One. 2019 Jul 8;14(7):e0218111. doi: 10.1371/journal.pone.0218111. eCollection 2019.
737 Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives.Bioorg Chem. 2019 Sep;90:103084. doi: 10.1016/j.bioorg.2019.103084. Epub 2019 Jun 26.
738 A Novel (18)F-Labeled Radioligand for Positron Emission Tomography Imaging of 11-Hydroxysteroid Dehydrogenase (11-HSD1): Synthesis and Preliminary Evaluation in Nonhuman Primates.ACS Chem Neurosci. 2019 May 15;10(5):2450-2458. doi: 10.1021/acschemneuro.8b00715. Epub 2019 Feb 19.
739 Neurosteroid biosynthetic pathways changes in prefrontal cortex in Alzheimer's disease.Neurobiol Aging. 2011 Nov;32(11):1964-76. doi: 10.1016/j.neurobiolaging.2009.12.014. Epub 2009 Dec 31.
740 In vitro study of interaction of 17-hydroxysteroid dehydrogenase type 10 and cyclophilin D and its potential implications for Alzheimer's disease.Sci Rep. 2019 Nov 13;9(1):16700. doi: 10.1038/s41598-019-53157-7.
741 Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease.Prostaglandins Leukot Essent Fatty Acids. 2011 Nov;85(5):197-203. doi: 10.1016/j.plefa.2011.04.021. Epub 2011 May 4.
742 Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases.Int J Mol Sci. 2019 Oct 9;20(20):4976. doi: 10.3390/ijms20204976.
743 Jujuboside A promotes A clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPAR pathway.Theranostics. 2018 Jul 30;8(15):4262-4278. doi: 10.7150/thno.26164. eCollection 2018.
744 Phosphatase 2A Inhibition Affects Endoplasmic Reticulum and Mitochondria Homeostasis Via Cytoskeletal Alterations in Brain Endothelial Cells.Mol Neurobiol. 2017 Jan;54(1):154-168. doi: 10.1007/s12035-015-9640-1. Epub 2016 Jan 5.
745 Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease.Front Pharmacol. 2018 Jan 30;9:48. doi: 10.3389/fphar.2018.00048. eCollection 2018.
746 Novel compound VB-037 inhibits A aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease.Neurochem Int. 2019 May;125:175-186. doi: 10.1016/j.neuint.2019.01.021. Epub 2019 Jan 29.
747 HSP22 and its role in human neurological disease.Curr Neurovasc Res. 2011 Nov;8(4):323-33. doi: 10.2174/156720211798121034.
748 Heat Shock Proteins in Alzheimer's Disease: Role and Targeting.Int J Mol Sci. 2018 Sep 1;19(9):2603. doi: 10.3390/ijms19092603.
749 Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease.Behav Brain Res. 2014 Mar 15;261:193-201. doi: 10.1016/j.bbr.2013.12.028. Epub 2013 Dec 31.
750 Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.J Alzheimers Dis. 2016 May 7;53(1):349-61. doi: 10.3233/JAD-160046.
751 Depression in Alzheimer's disease: the effect of serotonin receptor gene variation.Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):40-3. doi: 10.1002/ajmg.b.10068.
752 Neural activity, memory, and dementias: serotonergic markers.Behav Pharmacol. 2017 Apr;28(2 and 3-Spec Issue):132-141. doi: 10.1097/FBP.0000000000000279.
753 The effect of chronic stimulation of serotonin receptor type 7 on recognition, passive avoidance memory, hippocampal long-term potentiation, and neuronal apoptosis in the amyloid protein treated rat.Psychopharmacology (Berl). 2018 May;235(5):1513-1525. doi: 10.1007/s00213-018-4862-3. Epub 2018 Apr 10.
754 Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease.Neurobiol Aging. 2020 Mar;87:139.e1-139.e7. doi: 10.1016/j.neurobiolaging.2019.10.017. Epub 2019 Nov 1.
755 Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer's Disease Are Associated with Oxidative Stress Regulation Mechanisms.J Alzheimers Dis. 2019;69(1):157-168. doi: 10.3233/JAD-180421.
756 Effects of the Novel IDO Inhibitor DWG-1036 on the Behavior of Male and Female 3xTg-AD Mice.Front Pharmacol. 2019 Sep 24;10:1044. doi: 10.3389/fphar.2019.01044. eCollection 2019.
757 Deletion of the type-1 interferon receptor in APPSWE/PS1E9 mice preserves cognitive function and alters glial phenotype.Acta Neuropathol Commun. 2016 Jul 11;4(1):72. doi: 10.1186/s40478-016-0341-4.
758 Modulation of Immune Responses toHerpes Simplex Virus Type1 by IFNL3 and IRF7 Polymorphisms: AStudy inAlzheimer's Disease.J Alzheimers Dis. 2017;60(3):1055-1063. doi: 10.3233/JAD-170520.
759 Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.J Cell Physiol. 2019 Dec;234(12):21860-21876. doi: 10.1002/jcp.28750. Epub 2019 May 8.
760 Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.Aging Cell. 2013 Apr;12(2):257-68. doi: 10.1111/acel.12049. Epub 2013 Mar 11.
761 Circulating IGFBP-2: a novel biomarker for incident dementia.Ann Clin Transl Neurol. 2019 Sep;6(9):1659-1670. doi: 10.1002/acn3.50854. Epub 2019 Aug 2.
762 Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease.J Alzheimers Dis. 2019;67(3):893-910. doi: 10.3233/JAD-180833.
763 Amyloid precursor protein, an androgen-regulated gene, is targeted by RNA-binding protein PSF/SFPQ in neuronal cells.Genes Cells. 2019 Nov;24(11):719-730. doi: 10.1111/gtc.12721. Epub 2019 Oct 15.
764 Metaflammasome components in the human brain: a role in dementia with Alzheimer's pathology?.Brain Pathol. 2017 May;27(3):266-275. doi: 10.1111/bpa.12388. Epub 2016 Jun 8.
765 Anti-interleukin-17A and anti-interleukin-23 antibodies may be effective against Alzheimer's disease: Role of neutrophils in the pathogenesis.Brain Behav. 2020 Jan;10(1):e01504. doi: 10.1002/brb3.1504. Epub 2019 Dec 17.
766 Genetic Determinants of Survival in Patientswith Alzheimers Disease.J Alzheimers Dis. 2015;45(2):651-8. doi: 10.3233/JAD-142442.
767 Association of interleukin-I beta and receptor antagonist gene polymorphisms with late onset Alzheimer's disease in Taiwan Chinese.Eur J Neurol. 2005 Aug;12(8):609-13. doi: 10.1111/j.1468-1331.2005.01033.x.
768 Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein.Sci Rep. 2019 Feb 21;9(1):2460. doi: 10.1038/s41598-018-36650-3.
769 An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.Genome Med. 2018 Jan 29;10(1):7. doi: 10.1186/s13073-018-0513-x.
770 Neurotrophin Receptor p75 mRNA Level in Peripheral Blood Cells of Patients with Alzheimer's Disease.Neurotox Res. 2019 Jul;36(1):101-107. doi: 10.1007/s12640-019-00035-9. Epub 2019 Apr 11.
771 Assessment of IL-31 levels and disease severity in children with atopic dermatitis.Allergol Immunopathol (Madr). 2018 Jul-Aug;46(4):322-325. doi: 10.1016/j.aller.2017.10.005. Epub 2018 Mar 17.
772 Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases.Front Neurosci. 2019 Oct 18;13:1112. doi: 10.3389/fnins.2019.01112. eCollection 2019.
773 Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells.Viruses. 2019 Feb 13;11(2):154. doi: 10.3390/v11020154.
774 Interleukin 9 alterations linked to alzheimer disease in african americans.Ann Neurol. 2019 Sep;86(3):407-418. doi: 10.1002/ana.25543. Epub 2019 Jul 22.
775 Elevating Integrin-linked Kinase expression has rescued hippocampal neurogenesis and memory deficits in an AD animal model.Brain Res. 2018 Sep 15;1695:65-77. doi: 10.1016/j.brainres.2018.05.024. Epub 2018 May 19.
776 Corrigendum: Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.Neural Regen Res. 2020 Jun;15(6):1165. doi: 10.4103/1673-5374.270163.
777 Developmental Expression and Dysregulation of miR-146a and miR-155 in Down's Syndrome and Mouse Models of Down's Syndrome and Alzheimer's Disease.Curr Alzheimer Res. 2017;14(12):1305-1317. doi: 10.2174/1567205014666170706112701.
778 Loss of interleukin receptor-associated kinase 4 signaling suppresses amyloid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease.J Neurosci. 2012 Oct 24;32(43):15112-23. doi: 10.1523/JNEUROSCI.1729-12.2012.
779 Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling.Hum Exp Toxicol. 2018 Oct;37(10):1092-1104. doi: 10.1177/0960327118755256. Epub 2018 Feb 6.
780 IRF-8 is Involved in Amyloid-(1-40) (A(1-40))-induced Microglial Activation: a New Implication in Alzheimer's Disease.J Mol Neurosci. 2017 Oct;63(2):159-164. doi: 10.1007/s12031-017-0966-1. Epub 2017 Aug 31.
781 Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.Neural Regen Res. 2019 Aug;14(8):1330-1334. doi: 10.4103/1673-5374.253535.
782 CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease.Glia. 2019 May;67(5):844-856. doi: 10.1002/glia.23575. Epub 2018 Dec 26.
783 Alpha2beta1 and alphaVbeta1 integrin signaling pathways mediate amyloid-beta-induced neurotoxicity.Neurobiol Aging. 2007 Feb;28(2):226-37. doi: 10.1016/j.neurobiolaging.2005.12.002. Epub 2006 Jan 18.
784 On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.Genet Epidemiol. 2017 May;41(4):332-340. doi: 10.1002/gepi.22040. Epub 2017 Mar 20.
785 Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease.J Alzheimers Dis. 2019;72(4):1217-1231. doi: 10.3233/JAD-190796.
786 Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis.J Neurochem. 2000 Nov;75(5):1852-61. doi: 10.1046/j.1471-4159.2000.0751852.x.
787 A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice.Horm Behav. 2020 Feb;118:104640. doi: 10.1016/j.yhbeh.2019.104640. Epub 2019 Nov 28.
788 Network-based approach to identify molecular signatures and therapeutic agents in Alzheimer's disease.Comput Biol Chem. 2019 Feb;78:431-439. doi: 10.1016/j.compbiolchem.2018.12.011. Epub 2018 Dec 26.
789 Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer's disease.Cell Death Dis. 2018 Jul 26;9(8):820. doi: 10.1038/s41419-018-0886-1.
790 Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.J Neurochem. 2004 Nov;91(3):547-57. doi: 10.1111/j.1471-4159.2004.02771.x.
791 Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease.Neuropharmacology. 2015 May;92:8-15. doi: 10.1016/j.neuropharm.2014.12.033. Epub 2015 Jan 8.
792 Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster.J Korean Med Sci. 2019 Aug 26;34(33):e225. doi: 10.3346/jkms.2019.34.e225.
793 Discovery by the Epistasis Project of an epistatic interaction between the GSTM3 gene and the HHEX/IDE/KIF11 locus in the risk of Alzheimer's disease.Neurobiol Aging. 2013 Apr;34(4):1309.e1-7. doi: 10.1016/j.neurobiolaging.2012.08.010. Epub 2012 Oct 1.
794 Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.Neurobiol Dis. 2019 Jul;127:410-418. doi: 10.1016/j.nbd.2019.03.021. Epub 2019 Mar 25.
795 KIR2DS2/KIR2DL2/HLA-C1 Haplotype Is Associated with Alzheimer's Disease: Implication for the Role of Herpesvirus Infections.J Alzheimers Dis. 2019;67(4):1379-1389. doi: 10.3233/JAD-180777.
796 Increased free prostate specific antigen serum levels in Alzheimer's disease, correlation with Cognitive Decline.J Neurol Sci. 2019 May 15;400:188-193. doi: 10.1016/j.jns.2019.04.006. Epub 2019 Apr 5.
797 AMYPAD Diagnostic and Patient Management Study: Rationale and design.Alzheimers Dement. 2019 Mar;15(3):388-399. doi: 10.1016/j.jalz.2018.09.003. Epub 2018 Oct 16.
798 Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.EMBO Mol Med. 2018 Mar;10(3):e8184. doi: 10.15252/emmm.201708184.
799 Whole exome sequence-based association analyses of plasma amyloid- in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study.PLoS One. 2017 Jul 13;12(7):e0180046. doi: 10.1371/journal.pone.0180046. eCollection 2017.
800 Development of a Rapid Fluorescence-Based High-Throughput Screening Assay to Identify Novel Kynurenine 3-Monooxygenase Inhibitor Scaffolds.SLAS Discov. 2018 Jul;23(6):554-560. doi: 10.1177/2472555218757180. Epub 2018 Feb 8.
801 Neuropeptides in Alzheimer's Disease: An Update.Curr Alzheimer Res. 2019;16(6):544-558. doi: 10.2174/1567205016666190503152555.
802 Distinct Rab7-related Endosomal-Autophagic-Lysosomal Dysregulation Observed in Cortex and Hippocampus in APPswe/PSEN1dE9 Mouse Model of Alzheimer's Disease.Chin Med J (Engl). 2017 Dec 20;130(24):2941-2950. doi: 10.4103/0366-6999.220311.
803 Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment.PLoS One. 2017 May 2;12(5):e0176760. doi: 10.1371/journal.pone.0176760. eCollection 2017.
804 Lipopolysaccharide-Binding Protein, Soluble CD14, and the Long-Term Risk of Alzheimer's Disease: A Nested Case-Control Pilot Study of Older Community Dwellers from the Three-City Cohort.J Alzheimers Dis. 2019;71(3):751-761. doi: 10.3233/JAD-190295.
805 The level of 24-Hydroxycholesteryl Esters is an Early Marker of Alzheimer's Disease.J Alzheimers Dis. 2017;56(2):825-833. doi: 10.3233/JAD-160930.
806 Lymphocyte-specific protein tyrosine kinase is a novel risk gene for Alzheimer disease.J Neurol Sci. 2005 Nov 15;238(1-2):53-7. doi: 10.1016/j.jns.2005.06.017. Epub 2005 Aug 16.
807 Peripheral lipid oxidative stress markers are related to vascular risk factors and subcortical small vessel disease.Neurobiol Aging. 2017 Nov;59:91-97. doi: 10.1016/j.neurobiolaging.2017.06.029. Epub 2017 Jul 11.
808 N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain.Acta Neuropathol Commun. 2019 Nov 13;7(1):177. doi: 10.1186/s40478-019-0831-2.
809 Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease.J Neuropathol Exp Neurol. 2010 Mar;69(3):253-61. doi: 10.1097/NEN.0b013e3181d072cf.
810 LIF, a Novel Myokine, Protects Against Amyloid-Beta-Induced Neurotoxicity via Akt-Mediated Autophagy Signaling in Hippocampal Cells.Int J Neuropsychopharmacol. 2019 Jun 3;22(6):402-414. doi: 10.1093/ijnp/pyz016.
811 Expression of LIF and LIF receptor beta in Alzheimer's and Parkinson's diseases.Acta Neurol Scand. 2010 Jan;121(1):44-50. doi: 10.1111/j.1600-0404.2009.01179.x.
812 Circular RNA and Alzheimer's Disease.Adv Exp Med Biol. 2018;1087:239-243. doi: 10.1007/978-981-13-1426-1_19.
813 Inhibiting amyloid- cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.Nat Chem. 2018 Dec;10(12):1213-1221. doi: 10.1038/s41557-018-0147-z. Epub 2018 Oct 8.
814 LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice.CNS Neurosci Ther. 2018 May;24(5):381-393. doi: 10.1111/cns.12809. Epub 2018 Feb 9.
815 Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.Am J Pathol. 2012 Feb;180(2):526-40. doi: 10.1016/j.ajpath.2011.10.027. Epub 2011 Dec 3.
816 Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.Hum Genet. 2019 Mar;138(3):271-285. doi: 10.1007/s00439-019-01988-9. Epub 2019 Feb 25.
817 Changes of renin-angiotensin system-related aminopeptidases in early stage Alzheimer's disease.Exp Gerontol. 2017 Mar;89:1-7. doi: 10.1016/j.exger.2017.01.006. Epub 2017 Jan 7.
818 Extracorporeal apheresis therapy for Alzheimer disease-targeting lipids, stress, and inflammation.Mol Psychiatry. 2020 Feb;25(2):275-282. doi: 10.1038/s41380-019-0542-x. Epub 2019 Oct 8.
819 Harnessing low-density lipoprotein receptor protein 6 (LRP6) genetic variation and Wnt signaling for innovative diagnostics in complex diseases.Pharmacogenomics J. 2018 May 22;18(3):351-358. doi: 10.1038/tpj.2017.28. Epub 2017 Jul 11.
820 Effects of anti-inflammatory and adaptogenic herbal extracts on gene expression of eicosanoids signaling pathways in isolated brain cells.Phytomedicine. 2019 Jul;60:152881. doi: 10.1016/j.phymed.2019.152881. Epub 2019 Mar 10.
821 Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease.Neurosci Lett. 2009 Mar 20;452(3):277-80. doi: 10.1016/j.neulet.2009.01.071. Epub 2009 Feb 4.
822 Amelioration of amyloid -FcRIIb neurotoxicity and tau pathologies by targeting LYN.FASEB J. 2019 Mar;33(3):4300-4313. doi: 10.1096/fj.201800926R. Epub 2018 Dec 12.
823 Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster.FEBS J. 2016 Oct;283(19):3508-3522. doi: 10.1111/febs.13830.
824 Differing associations between A accumulation, hypoperfusion, blood-brain barrier dysfunction and loss of PDGFRB pericyte marker in the precuneus and parietal white matter in Alzheimer's disease.J Cereb Blood Flow Metab. 2018 Jan;38(1):103-115. doi: 10.1177/0271678X17690761. Epub 2017 Feb 2.
825 Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against A toxicity via attenuating A-induced endoplasmic reticulum stress.J Neuroinflammation. 2019 Feb 13;16(1):35. doi: 10.1186/s12974-019-1429-0.
826 MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer's Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance.Mol Neurobiol. 2019 Jun;56(6):4518-4529. doi: 10.1007/s12035-018-1394-0. Epub 2018 Oct 18.
827 Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.Autophagy. 2017;13(11):1969-1980. doi: 10.1080/15548627.2017.1371393. Epub 2017 Oct 4.
828 ApoE and SNAP-25 Polymorphisms Predict the Outcome of Multidimensional Stimulation Therapy Rehabilitation in Alzheimer's Disease.Neurorehabil Neural Repair. 2016 Oct;30(9):883-93. doi: 10.1177/1545968316642523. Epub 2016 Apr 13.
829 Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer's Disease and Brain Aging.J Alzheimers Dis. 2018;61(1):259-263. doi: 10.3233/JAD-170645.
830 Multistage Screening Reveals 3-Substituted Indolin-2-one Derivatives as Novel and Isoform-Selective c-Jun N-terminal Kinase 3 (JNK3) Inhibitors: Implications to Drug Discovery for Potential Treatment of Neurodegenerative Diseases.J Med Chem. 2019 Jul 25;62(14):6645-6664. doi: 10.1021/acs.jmedchem.9b00537. Epub 2019 Jul 15.
831 Optimized liposomes with transactivator of transcription peptide and anti-apoptotic drugs to target hippocampal neurons and prevent tau-hyperphosphorylated neurodegeneration.Acta Biomater. 2019 Mar 15;87:207-222. doi: 10.1016/j.actbio.2019.01.065. Epub 2019 Feb 1.
832 Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies.Curr Alzheimer Res. 2005 Jan;2(1):3-18. doi: 10.2174/1567205052772713.
833 Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid- Aggregation Inhibitor.ACS Omega. 2017 Jan 31;2(1):243-250. doi: 10.1021/acsomega.6b00397. Epub 2017 Jan 25.
834 MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease.J Biol Chem. 2006 Aug 18;281(33):23658-67. doi: 10.1074/jbc.M513646200. Epub 2006 Jun 14.
835 Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes.Transl Psychiatry. 2015 Jun 16;5(6):e584. doi: 10.1038/tp.2015.78.
836 Comprehensive phosphoproteome analysis unravels the core signaling network that initiates the earliest synapse pathology in preclinical Alzheimer's disease brain.Hum Mol Genet. 2015 Jan 15;24(2):540-58. doi: 10.1093/hmg/ddu475. Epub 2014 Sep 17.
837 Mapping the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory to the Health Utility Index Mark III.Qual Life Res. 2019 Jan;28(1):131-139. doi: 10.1007/s11136-018-1991-4. Epub 2018 Sep 1.
838 Angiotensin-(1-7) administration attenuates Alzheimer's disease-like neuropathology in rats with streptozotocin-induced diabetes via Mas receptor activation.Neuroscience. 2017 Mar 27;346:267-277. doi: 10.1016/j.neuroscience.2017.01.027. Epub 2017 Jan 29.
839 The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.Mol Cell Proteomics. 2012 Nov;11(11):1274-88. doi: 10.1074/mcp.M112.019364. Epub 2012 Aug 9.
840 Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.Biochemistry. 2000 Mar 28;39(12):3206-15. doi: 10.1021/bi992211q.
841 Ghrelin cascade changes in the peripheral blood of Japanese patients with Alzheimer's disease.J Psychiatr Res. 2018 Dec;107:79-85. doi: 10.1016/j.jpsychires.2018.10.011. Epub 2018 Oct 18.
842 Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus.PLoS One. 2014 Mar 17;9(3):e91974. doi: 10.1371/journal.pone.0091974. eCollection 2014.
843 Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer's Disease.Mol Neurobiol. 2019 Jan;56(1):174-185. doi: 10.1007/s12035-018-1040-x. Epub 2018 Apr 23.
844 A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk.J Alzheimers Dis. 2017;56(3):1065-1074. doi: 10.3233/JAD-161113.
845 Acidifying Endolysosomes Prevented Low-Density Lipoprotein-Induced Amyloidogenesis.J Alzheimers Dis. 2019;67(1):393-410. doi: 10.3233/JAD-180941.
846 Low Cerebrospinal Fluid Levels of Melanotransferrin Are Associated With Conversion of Mild Cognitively Impaired Subjects to Alzheimer's Disease.Front Neurosci. 2019 Mar 8;13:181. doi: 10.3389/fnins.2019.00181. eCollection 2019.
847 Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8.Front Neurosci. 2019 Jun 4;13:569. doi: 10.3389/fnins.2019.00569. eCollection 2019.
848 A comprehensive appraisal on Crocus chrysanthus (Herb.) Herb. flower extracts with HPLC-MS/MS profiles, antioxidant and enzyme inhibitory properties.J Pharm Biomed Anal. 2019 Feb 5;164:581-589. doi: 10.1016/j.jpba.2018.11.022. Epub 2018 Nov 12.
849 Alleviation of Neuropathology by Inhibition of Monoacylglycerol Lipase in APP Transgenic Mice Lacking CB2 Receptors.Mol Neurobiol. 2018 Jun;55(6):4802-4810. doi: 10.1007/s12035-017-0689-x. Epub 2017 Jul 21.
850 Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.FASEB J. 2019 Feb;33(2):2910-2927. doi: 10.1096/fj.201801076R. Epub 2018 Oct 17.
851 In-Silico Characterization and in-Vivo Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease.Front Pharmacol. 2018 Aug 2;9:730. doi: 10.3389/fphar.2018.00730. eCollection 2018.
852 Genetic variations and humoral immune responses to myelin oligodendroglia glycoprotein in adult phenotypes of X-linked adrenoleukodystrophy.J Neuroimmunol. 2003 Feb;135(1-2):148-53. doi: 10.1016/s0165-5728(02)00445-9.
853 Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease.Front Neurosci. 2019 Sep 24;13:990. doi: 10.3389/fnins.2019.00990. eCollection 2019.
854 Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.Acta Neuropathol Commun. 2018 Oct 26;6(1):113. doi: 10.1186/s40478-018-0615-0.
855 Direct Interaction of Selenoprotein R with Clusterin and Its Possible Role in Alzheimer's Disease.PLoS One. 2013 Jun 21;8(6):e66384. doi: 10.1371/journal.pone.0066384. Print 2013.
856 Myostatin Is Associated With Cognitive Decline in an Animal Model of Alzheimer's Disease.Mol Neurobiol. 2019 Mar;56(3):1984-1991. doi: 10.1007/s12035-018-1201-y. Epub 2018 Jul 7.
857 Melatonin receptor type 1A gene linked to Alzheimer's disease in old age.Sleep. 2018 Jul 1;41(7):zsy103. doi: 10.1093/sleep/zsy103.
858 Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer's disease via C/EBP/miR-125b pathway.Aging Cell. 2019 Apr;18(2):e12902. doi: 10.1111/acel.12902. Epub 2019 Feb 1.
859 Variants of Base Excision Repair Genes MUTYH , PARP1 and XRCC1 in Alzheimer's Disease Risk.Neuropsychobiology. 2015;71(3):176-86. doi: 10.1159/000381985. Epub 2015 May 13.
860 Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-B pathway in rats.Biomed Pharmacother. 2019 Mar;111:315-324. doi: 10.1016/j.biopha.2018.10.201. Epub 2018 Dec 24.
861 Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain.Eur J Neurosci. 2004 Dec;20(12):3489-97. doi: 10.1111/j.1460-9568.2004.03852.x.
862 Neuroprotective effects of N-acetyl cysteine on primary hippocampus neurons against hydrogen peroxide-induced injury are mediated via inhibition of mitogen-activated protein kinases signal transduction and antioxidative action.Mol Med Rep. 2018 May;17(5):6647-6654. doi: 10.3892/mmr.2018.8699. Epub 2018 Mar 7.
863 Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid.J Biol Chem. 2008 Jan 4;283(1):6-16. doi: 10.1074/jbc.M706124200. Epub 2007 Oct 6.
864 Formation of adenovirus DNA replication compartments and viral DNA accumulation sites by host chromatin regulatory proteins including NPM1.FEBS J. 2020 Jan;287(1):205-217. doi: 10.1111/febs.15027. Epub 2019 Aug 9.
865 Amyloid- Induces AMPA Receptor Ubiquitination and Degradation in Primary Neurons and Human Brains of Alzheimer's Disease.J Alzheimers Dis. 2018;62(4):1789-1801. doi: 10.3233/JAD-170879.
866 NEDD9 gene polymorphism influences the risk of Alzheimer disease and cognitive function in Chinese older persons.Alzheimer Dis Assoc Disord. 2012 Jan-Mar;26(1):88-90. doi: 10.1097/WAD.0b013e3182135ef3.
867 Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer's Disease.Front Aging Neurosci. 2019 Mar 26;11:62. doi: 10.3389/fnagi.2019.00062. eCollection 2019.
868 Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study.Clin Neurophysiol. 2019 Oct;130(10):1813-1824. doi: 10.1016/j.clinph.2019.06.229. Epub 2019 Jul 12.
869 The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo.Methods Mol Biol. 2019;1951:189-207. doi: 10.1007/978-1-4939-9130-3_15.
870 Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3.Neurobiol Aging. 2018 Jun;66:179.e17-179.e29. doi: 10.1016/j.neurobiolaging.2018.01.015. Epub 2018 Feb 2.
871 Genetic association between Notch4 polymorphisms and Alzheimer's disease in the Japanese population.J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):350-1. doi: 10.1093/gerona/62.4.350.
872 Neurochemical Characterization of PSA-NCAM(+) Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex.Neuroscience. 2018 Feb 21;372:289-303. doi: 10.1016/j.neuroscience.2017.12.019.
873 Expression of Quinone Reductase-2 in the Cortex Is a Muscarinic Acetylcholine Receptor-Dependent Memory Consolidation Constraint.J Neurosci. 2015 Nov 25;35(47):15568-81. doi: 10.1523/JNEUROSCI.1170-15.2015.
874 Effects of NR1H3 genetic variation on the expression of liver X receptor and the progression of Alzheimer's disease.PLoS One. 2013 Nov 20;8(11):e80700. doi: 10.1371/journal.pone.0080700. eCollection 2013.
875 Association study of the GAB2 gene with the risk of developing Alzheimer's disease.Neurobiol Dis. 2008 Apr;30(1):103-6. doi: 10.1016/j.nbd.2007.12.006. Epub 2008 Jan 5.
876 Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus.Brain Res. 2019 Sep 15;1719:217-224. doi: 10.1016/j.brainres.2019.06.004. Epub 2019 Jun 6.
877 Decreased trkA neurotrophin receptor expression in the parietal cortex of patients with Alzheimer's disease.Neurosci Lett. 1998 Jan 30;241(2-3):151-4. doi: 10.1016/s0304-3940(98)00019-6.
878 Key mechanisms underlying netrin-1 prevention of impaired spatial and object memory in A(1-42) CA1-injected rats.Clin Exp Pharmacol Physiol. 2019 Jan;46(1):86-93. doi: 10.1111/1440-1681.13020. Epub 2018 Sep 3.
879 The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease.J Alzheimers Dis. 2018;64(4):1149-1161. doi: 10.3233/JAD-180276.
880 Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.J Neurosci. 2015 Apr 15;35(15):5969-82. doi: 10.1523/JNEUROSCI.4668-14.2015.
881 Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran.J Psychoactive Drugs. 2017 Jul-Aug;49(3):242-251. doi: 10.1080/02791072.2017.1290303. Epub 2017 Mar 1.
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883 Cross-species microarray analysis with the OSCAR system suggests an INSR->Pax6->NQO1 neuro-protective pathway in aging and Alzheimer's disease.Nucleic Acids Res. 2007 Jul;35(Web Server issue):W105-14. doi: 10.1093/nar/gkm408. Epub 2007 Jun 1.
884 Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes.J Biol Chem. 1998 Feb 13;273(7):4112-8. doi: 10.1074/jbc.273.7.4112.
885 Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?.Neurosci Lett. 2009 Jan 2;449(1):76-80. doi: 10.1016/j.neulet.2008.10.081. Epub 2008 Oct 28.
886 Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model.J Alzheimers Dis. 2017;55(3):1273-1283. doi: 10.3233/JAD-160569.
887 P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model.J Exp Med. 2018 Jun 4;215(6):1649-1663. doi: 10.1084/jem.20171487. Epub 2018 May 3.
888 Role of purinergic receptors in the Alzheimer's disease.Purinergic Signal. 2018 Dec;14(4):331-344. doi: 10.1007/s11302-018-9629-0. Epub 2018 Oct 25.
889 Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.J Neural Transm (Vienna). 2008 Aug;115(8):1165-72. doi: 10.1007/s00702-008-0067-y. Epub 2008 May 28.
890 Association between Polymorphisms of the AKT1 Gene Promoter and Risk of the Alzheimer's Disease in a Chinese Han Population with Type 2 Diabetes.CNS Neurosci Ther. 2015 Aug;21(8):619-25. doi: 10.1111/cns.12430. Epub 2015 Jul 14.
891 p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.J Biol Chem. 2008 May 16;283(20):14132-43. doi: 10.1074/jbc.M708034200. Epub 2008 Mar 17.
892 Aluminum-induced "mixed" cell death in mice cerebral tissue and potential intervention.Neurotox Res. 2020 Apr;37(4):835-846. doi: 10.1007/s12640-019-00123-w. Epub 2019 Nov 13.
893 Lipid lowering and Alzheimer disease risk: A mendelian randomization study.Ann Neurol. 2020 Jan;87(1):30-39. doi: 10.1002/ana.25642.
894 Comprehensive analysis of the lncRNA-associated ceRNA network identifies neuroinflammation biomarkers for Alzheimer's disease.Mol Omics. 2019 Dec 2;15(6):459-469. doi: 10.1039/c9mo00129h.
895 Phosphodiesterase 10 Inhibitors - Novel Perspectives for Psychiatric and Neurodegenerative Drug Discovery.Curr Med Chem. 2018;25(29):3455-3481. doi: 10.2174/0929867325666180309110629.
896 Discovery of Novel Phosphodiesterase-2A Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.J Chem Inf Model. 2017 Feb 27;57(2):355-364. doi: 10.1021/acs.jcim.6b00551. Epub 2017 Jan 18.
897 Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.Eur J Med Chem. 2019 Feb 1;163:512-526. doi: 10.1016/j.ejmech.2018.12.013. Epub 2018 Dec 7.
898 Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors.ACS Chem Neurosci. 2019 Mar 20;10(3):1765-1782. doi: 10.1021/acschemneuro.8b00648. Epub 2018 Dec 21.
899 Amyloid -induced impairments on mitochondrial dynamics, hippocampal neurogenesis, and memory are restored by phosphodiesterase 7 inhibition.Alzheimers Res Ther. 2018 Feb 20;10(1):24. doi: 10.1186/s13195-018-0352-4.
900 Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease.ACS Chem Neurosci. 2019 Jan 16;10(1):537-551. doi: 10.1021/acschemneuro.8b00376. Epub 2018 Oct 12.
901 Automated PDF highlighting to support faster curation of literature for Parkinson's and Alzheimer's disease.Database (Oxford). 2017 Jan 1;2017(1):bax027. doi: 10.1093/database/bax027.
902 Understanding the function of ABCA7 in Alzheimer's disease.Biochem Soc Trans. 2015 Oct;43(5):920-3. doi: 10.1042/BST20150105.
903 Altered microglia and neurovasculature in the Alzheimer's disease cerebellum.Neurobiol Dis. 2019 Dec;132:104589. doi: 10.1016/j.nbd.2019.104589. Epub 2019 Aug 24.
904 Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression.Sci Rep. 2017 Aug 22;7(1):9115. doi: 10.1038/s41598-017-09481-x.
905 Analysis of DNA variations in promoter region of HCNP gene with Alzheimer's disease.Biochem Biophys Res Commun. 2009 Feb 6;379(2):272-6. doi: 10.1016/j.bbrc.2008.12.037. Epub 2008 Dec 25.
906 PEMT G523A (V175M) is associated with sporadic Alzheimer's disease in a Chinese population.J Mol Neurosci. 2012 Mar;46(3):505-8. doi: 10.1007/s12031-011-9630-3. Epub 2011 Sep 1.
907 Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity.J Biol Chem. 2015 May 15;290(20):12504-13. doi: 10.1074/jbc.M114.618157. Epub 2015 Mar 26.
908 Development of a High-Sensitivity Method for the Measurement of Human Nasal A42, Tau, and Phosphorylated Tau.J Alzheimers Dis. 2018;62(2):737-744. doi: 10.3233/JAD-170962.
909 Epitope mapping of anti-PGRMC1 antibodies reveals the non-conventional membrane topology of PGRMC1 on the cell surface.Sci Rep. 2019 Jan 24;9(1):653. doi: 10.1038/s41598-018-37441-6.
910 TTC7 and Hyccin Regulate Neuronal A42 Accumulation and its Associated Neural Deficits in A42-Expressing Drosophila.J Alzheimers Dis. 2018;65(3):1001-1010. doi: 10.3233/JAD-170907.
911 A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity.Biosci Rep. 2016 Apr 15;36(2):e00319. doi: 10.1042/BSR20160040. Print 2016.
912 Protective effects of 5-HT(1A) receptor antagonist and 5-HT(2A) receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.J Chem Neuroanat. 2019 Mar;96:140-147. doi: 10.1016/j.jchemneu.2019.01.008. Epub 2019 Jan 23.
913 Bee Venom Soluble Phospholipase A2 Exerts Neuroprotective Effects in a Lipopolysaccharide-Induced Mouse Model of Alzheimer's Disease via Inhibition of Nuclear Factor-Kappa B.Front Aging Neurosci. 2019 Nov 1;11:287. doi: 10.3389/fnagi.2019.00287. eCollection 2019.
914 Meta-analysis of the association between urokinase-plasminogen activator gene rs2227564 polymorphism and Alzheimer's disease.Am J Alzheimers Dis Other Demen. 2013 Aug;28(5):517-23. doi: 10.1177/1533317513494450. Epub 2013 Jun 28.
915 Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains.Brain Res. 2002 Feb 1;926(1-2):69-79. doi: 10.1016/s0006-8993(01)03298-x.
916 Suppressing aberrant phospholipase D1 signaling in 3xTg Alzheimer's disease mouse model promotes synaptic resilience.Sci Rep. 2019 Dec 4;9(1):18342. doi: 10.1038/s41598-019-54974-6.
917 PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.Mol Neurobiol. 2016 Aug;53(6):4034-4045. doi: 10.1007/s12035-015-9353-5. Epub 2015 Jul 21.
918 Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer's disease model mice.PLoS One. 2019 Jul 15;14(7):e0219691. doi: 10.1371/journal.pone.0219691. eCollection 2019.
919 Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease.Hum Mol Genet. 2015 Oct 1;24(19):5388-403. doi: 10.1093/hmg/ddv262. Epub 2015 Jul 9.
920 Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.ACS Chem Biol. 2017 Feb 17;12(2):342-346. doi: 10.1021/acschembio.6b00922. Epub 2016 Dec 28.
921 Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.Brain Pathol. 2018 Nov;28(6):933-946. doi: 10.1111/bpa.12592. Epub 2018 Feb 21.
922 Synthesis of (11)C-labeled DNA polymerase- inhibitor 5-methoxyflavone and PET/CT imaging thereof.Nucl Med Biol. 2019 Nov-Dec;78-79:17-22. doi: 10.1016/j.nucmedbio.2019.10.005. Epub 2019 Oct 23.
923 In vivo and in vitro studies on the roles of p38 mitogen-activated protein kinase and NADPH-cytochrome P450 reductase in Alzheimer's disease.Exp Ther Med. 2017 Nov;14(5):4755-4760. doi: 10.3892/etm.2017.5182. Epub 2017 Sep 22.
924 Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model.Autophagy. 2020 Jan;16(1):52-69. doi: 10.1080/15548627.2019.1596488. Epub 2019 Apr 6.
925 PPAR Gamma Coactivator 1 Beta (PGC-1) Reduces Mammalian Target of Rapamycin (mTOR) Expression via a SIRT1-Dependent Mechanism in Neurons.Cell Mol Neurobiol. 2017 Jul;37(5):879-887. doi: 10.1007/s10571-016-0425-5. Epub 2016 Sep 15.
926 Normalization of gene expression using SYBR green qPCR: a case for paraoxonase 1 and 2 in Alzheimer's disease brains.J Neurosci Methods. 2011 Aug 30;200(1):14-9. doi: 10.1016/j.jneumeth.2011.05.026. Epub 2011 Jun 13.
927 The dynamics of CD147 in Alzheimer's disease development and pathology.J Alzheimers Dis. 2011;26(4):593-605. doi: 10.3233/JAD-2011-110584.
928 Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease.J Neuropathol Exp Neurol. 2018 Feb 1;77(2):139-148. doi: 10.1093/jnen/nlx110.
929 MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.EMBO J. 2014 Aug 1;33(15):1667-80. doi: 10.15252/embj.201387576. Epub 2014 Jul 7.
930 Elevation of pS262-Tau and Demethylated PP2A in Retina Occurs Earlier than in Hippocampus During Hyperhomocysteinemia.J Alzheimers Dis. 2019;68(1):367-381. doi: 10.3233/JAD-180978.
931 Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.Subst Use Misuse. 2010 Sep;45(11):1809-26. doi: 10.3109/10826084.2010.482449.
932 Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases.Prog Neurobiol. 2012 May;97(2):220-38. doi: 10.1016/j.pneurobio.2011.11.002. Epub 2011 Dec 7.
933 Plasma Protein Biomarkers for the Prediction of CSF Amyloid and Tau and [(18)F]-Flutemetamol PET Scan Result.Front Aging Neurosci. 2018 Dec 11;10:409. doi: 10.3389/fnagi.2018.00409. eCollection 2018.
934 Peroxiredoxin 4 ameliorates amyloid beta oligomer-mediated apoptosis by inhibiting ER-stress in HT-22 hippocampal neuron cells.Cell Biol Toxicol. 2019 Dec;35(6):573-588. doi: 10.1007/s10565-019-09477-5. Epub 2019 May 30.
935 Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.J Neurochem. 2007 Dec;103(6):2462-70. doi: 10.1111/j.1471-4159.2007.04942.x. Epub 2007 Oct 1.
936 Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer's Disease Hippocampus.J Alzheimers Dis. 2018;63(3):1173-1189. doi: 10.3233/JAD-171008.
937 Scallop-derived plasmalogens attenuate the activation of PKC associated with the brain inflammation.Biochem Biophys Res Commun. 2018 Sep 5;503(2):837-842. doi: 10.1016/j.bbrc.2018.06.084. Epub 2018 Jun 21.
938 PKC deficits in Alzheimer's disease brains and skin fibroblasts.J Alzheimers Dis. 2015;43(2):491-509. doi: 10.3233/JAD-141221.
939 The protein arginine methyltransferase PRMT5 regulates A-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimer's disease.J Neurochem. 2015 Sep;134(5):969-77. doi: 10.1111/jnc.13191. Epub 2015 Jul 15.
940 Activated protein C in neuroprotection and malaria.Curr Opin Hematol. 2019 Sep;26(5):320-330. doi: 10.1097/MOH.0000000000000528.
941 Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.Neurobiol Aging. 2015 Apr;36(4):1629-1638. doi: 10.1016/j.neurobiolaging.2015.01.001. Epub 2015 Jan 7.
942 N-myc downstream-regulated gene 2 deficiency aggravates memory impairment in Alzheimer's disease.Behav Brain Res. 2020 Feb 3;379:112384. doi: 10.1016/j.bbr.2019.112384. Epub 2019 Nov 25.
943 A dual inhibitor of the proteasome catalytic subunits LMP2 and Y attenuates disease progression in mouse models of Alzheimer's disease.Sci Rep. 2019 Dec 5;9(1):18393. doi: 10.1038/s41598-019-54846-z.
944 Hematopoietic prostaglandin D synthase and DP1 receptor are selectively upregulated in microglia and astrocytes within senile plaques from human patients and in a mouse model of Alzheimer disease.J Neuropathol Exp Neurol. 2007 Jun;66(6):469-80. doi: 10.1097/01.jnen.0000240472.43038.27.
945 PGE2 EP1 receptor exacerbated neurotoxicity in a mouse model of cerebral ischemia and Alzheimer's disease.Neurobiol Aging. 2012 Sep;33(9):2215-9. doi: 10.1016/j.neurobiolaging.2011.09.017. Epub 2011 Oct 19.
946 Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.J Neurosci. 2005 Nov 2;25(44):10180-7. doi: 10.1523/JNEUROSCI.3591-05.2005.
947 PGE(2)-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.Neurobiol Aging. 2017 Feb;50:13-24. doi: 10.1016/j.neurobiolaging.2016.10.012. Epub 2016 Oct 17.
948 Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.Alzheimers Dement. 2008 Jan;4(1):6-13. doi: 10.1016/j.jalz.2007.10.015. Epub 2007 Dec 21.
949 Commentary on Giralt et al.: PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease.Exp Neurol. 2019 Jan;311:313-317. doi: 10.1016/j.expneurol.2018.08.011. Epub 2018 Aug 29.
950 A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer's disease.Sci Rep. 2017 Oct 17;7(1):13333. doi: 10.1038/s41598-017-13831-0.
951 Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B.Exp Gerontol. 2018 Apr;104:66-71. doi: 10.1016/j.exger.2018.02.005. Epub 2018 Feb 5.
952 The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.Sci Rep. 2017 Sep 18;7(1):11771. doi: 10.1038/s41598-017-12236-3.
953 Neuropeptide Y, peptide YY and aluminum in Alzheimer's disease: is there an etiological relationship?.J Inorg Biochem. 2001 Nov;87(1-2):51-6. doi: 10.1016/s0162-0134(01)00314-2.
954 Differential Expression of mRNAs in the Brain Tissues of Patients with Alzheimer's Disease Based on GEO Expression Profile and Its Clinical Significance.Biomed Res Int. 2019 Feb 26;2019:8179145. doi: 10.1155/2019/8179145. eCollection 2019.
955 In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.Bioorg Med Chem. 2019 Jan 15;27(2):354-363. doi: 10.1016/j.bmc.2018.12.007. Epub 2018 Dec 10.
956 RACK-1 expression and cytokine production in leukocytes obtained from AD patients.Aging Clin Exp Res. 2006 Apr;18(2):153-7. doi: 10.1007/BF03327432.
957 GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability.Sci Rep. 2016 May 19;6:26116. doi: 10.1038/srep26116.
958 Apolipoprotein E 4 Specifically Modulates the Hippocampus Functional Connectivity Network in Patients With Amnestic Mild Cognitive Impairment.Front Aging Neurosci. 2018 Sep 27;10:289. doi: 10.3389/fnagi.2018.00289. eCollection 2018.
959 Diet and Alzheimer's dementia - Nutritional approach to modulate inflammation.Pharmacol Biochem Behav. 2019 Sep;184:172743. doi: 10.1016/j.pbb.2019.172743. Epub 2019 Jul 26.
960 Specific protein biomarker patterns for Alzheimer's disease: improved diagnostics in progress.EPMA J. 2017 Sep 4;8(3):255-259. doi: 10.1007/s13167-017-0110-x. eCollection 2017 Sep.
961 Identification of molecular correlations of RBM8A with autophagy in Alzheimer's disease.Aging (Albany NY). 2019 Dec 9;11(23):11673-11685. doi: 10.18632/aging.102571. Epub 2019 Dec 9.
962 Role of N-terminal residues in A interactions with integrin receptor and cell surface.Biochim Biophys Acta. 2014 Oct;1838(10):2568-77. doi: 10.1016/j.bbamem.2014.06.011. Epub 2014 Jun 21.
963 APC/C(Cdh1)-Rock2 pathway controls dendritic integrity and memory.Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4513-4518. doi: 10.1073/pnas.1616024114. Epub 2017 Apr 10.
964 Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease.Mol Neurodegener. 2016 Jan 12;11:3. doi: 10.1186/s13024-016-0071-x.
965 Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against -amyloid.Sci Signal. 2019 Jun 25;12(587):eaaw9318. doi: 10.1126/scisignal.aaw9318.
966 Heat-Resistant Aphanizomenon flos-aquae (AFA) Extract (Klamin) as a Functional Ingredient in Food Strategy for Prevention of Oxidative Stress.Oxid Med Cell Longev. 2019 Nov 11;2019:9481390. doi: 10.1155/2019/9481390. eCollection 2019.
967 Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.J Neurosci. 2015 Oct 14;35(41):14042-56. doi: 10.1523/JNEUROSCI.2781-15.2015.
968 Genetic variation in the tau kinases pathway may modify the risk and age at onset of Alzheimer's disease.J Alzheimers Dis. 2011;27(2):291-7. doi: 10.3233/JAD-2011-110794.
969 Nogo-A expression in the human hippocampus in normal aging and in Alzheimer disease.J Neuropathol Exp Neurol. 2006 May;65(5):433-44. doi: 10.1097/01.jnen.0000222894.59293.98.
970 Novel roles for Nogo receptor in inflammation and disease.Trends Neurosci. 2008 May;31(5):221-6. doi: 10.1016/j.tins.2008.02.002. Epub 2008 Apr 18.
971 Calcitonin gene-related peptide (CGRP): A novel target for Alzheimer's disease.CNS Neurosci Ther. 2017 Jun;23(6):457-461. doi: 10.1111/cns.12696. Epub 2017 Apr 17.
972 Glial S100A6 Degrades -amyloid Aggregation through Targeting Competition with Zinc Ions.Aging Dis. 2019 Aug 1;10(4):756-769. doi: 10.14336/AD.2018.0912. eCollection 2019 Aug.
973 The S100B story: from biomarker to active factor in neural injury.J Neurochem. 2019 Jan;148(2):168-187. doi: 10.1111/jnc.14574. Epub 2018 Nov 12.
974 Serum amyloid A1 is involved in amyloid plaque aggregation and memory decline in amyloid beta abundant condition.Transgenic Res. 2019 Dec;28(5-6):499-508. doi: 10.1007/s11248-019-00166-x. Epub 2019 Aug 12.
975 Gender differences of peripheral plasma and liver metabolic profiling in APP/PS1 transgenic AD mice.Neuroscience. 2016 Sep 22;332:160-9. doi: 10.1016/j.neuroscience.2016.06.049. Epub 2016 Jul 5.
976 Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid -associated neural degeneration in Alzheimer's disease.Brain Pathol. 2013 May;23(3):274-84. doi: 10.1111/j.1750-3639.2012.00644.x. Epub 2012 Nov 1.
977 Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.Neurosci Lett. 2003 Dec 4;352(2):146-50. doi: 10.1016/j.neulet.2003.08.041.
978 Candidate gene analysis of semaphorins in patients with Alzheimer's disease.Neurol Sci. 2010 Apr;31(2):169-73. doi: 10.1007/s10072-009-0200-1. Epub 2009 Dec 3.
979 Comparative Serum Proteomic Analysis of the Effects of Sodium Selenate on a Mouse Model of Alzheimer's Disease.Biol Trace Elem Res. 2019 Dec;192(2):263-276. doi: 10.1007/s12011-019-01676-9. Epub 2019 Feb 21.
980 Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease.Am J Pathol. 1993 Sep;143(3):886-93.
981 Pigment Epithelium-Derived Factor Plays a Role in Alzheimer's Disease by Negatively Regulating A42.Neurotherapeutics. 2018 Jul;15(3):728-741. doi: 10.1007/s13311-018-0628-1.
982 Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.Neuroscience. 2019 Sep 15;416:126-136. doi: 10.1016/j.neuroscience.2019.07.050. Epub 2019 Aug 5.
983 TRPC6 mRNA levels in peripheral leucocytes of patients with Alzheimer's disease and mild cognitive impairment: A case-control study.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jun 8;92:279-284. doi: 10.1016/j.pnpbp.2019.01.009. Epub 2019 Jan 23.
984 Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.Mol Neurobiol. 2018 Oct;55(10):7839-7857. doi: 10.1007/s12035-018-0955-6. Epub 2018 Feb 22.
985 mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid- Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.J Alzheimers Dis. 2017;56(3):1015-1036. doi: 10.3233/JAD-161029.
986 Critical role of mitosis in spontaneous late-onset Alzheimer's disease; from a Shugoshin 1 cohesinopathy mouse model.Cell Cycle. 2018;17(19-20):2321-2334. doi: 10.1080/15384101.2018.1515554. Epub 2018 Sep 20.
987 Optimized turmeric extract reduces -Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice.Curr Alzheimer Res. 2012 May;9(4):500-6. doi: 10.2174/156720512800492459.
988 At the Crossing of ER Stress and MAMs: A Key Role of Sigma-1 Receptor?.Adv Exp Med Biol. 2020;1131:699-718. doi: 10.1007/978-3-030-12457-1_28.
989 Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases.Eur J Pharmacol. 2020 Jan 15;867:172847. doi: 10.1016/j.ejphar.2019.172847. Epub 2019 Dec 5.
990 Distinct patterns of sirtuin expression during progression of Alzheimer's disease.Neuromolecular Med. 2014 Jun;16(2):405-14. doi: 10.1007/s12017-014-8288-8. Epub 2014 Jan 25.
991 Emerging Roles of Sirtuin 6 in Alzheimer's Disease.J Mol Neurosci. 2018 Feb;64(2):157-161. doi: 10.1007/s12031-017-1005-y. Epub 2017 Dec 19.
992 Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans.Alzheimers Dement. 2017 Feb;13(2):119-129. doi: 10.1016/j.jalz.2016.09.002. Epub 2016 Oct 20.
993 Role of monocarboxylate transporter 4 in Alzheimer disease.Neurotoxicology. 2020 Jan;76:191-199. doi: 10.1016/j.neuro.2019.11.006. Epub 2019 Nov 16.
994 Kinetic modeling of [(18) F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain.J Neurochem. 2018 Mar;144(6):791-804. doi: 10.1111/jnc.14291. Epub 2018 Mar 25.
995 Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data.Genes Brain Behav. 2015 Nov;14(8):607-17. doi: 10.1111/gbb.12250. Epub 2015 Sep 23.
996 Region- and age-specific changes in glutamate transport in the APP23 mouse model for Alzheimer's disease.J Alzheimers Dis. 2011;24(2):287-300. doi: 10.3233/JAD-2011-101005.
997 Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21800-21811. doi: 10.1073/pnas.1903566116. Epub 2019 Oct 7.
998 Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-B Pathways.Mol Neurobiol. 2018 Jun;55(6):5031-5046. doi: 10.1007/s12035-017-0709-x. Epub 2017 Aug 15.
999 Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease.J Pharm Sci. 2019 Jul;108(7):2484-2489. doi: 10.1016/j.xphs.2019.02.016. Epub 2019 Feb 27.
1000 NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.Hum Mol Genet. 2015 Jun 1;24(11):3058-81. doi: 10.1093/hmg/ddv059. Epub 2015 Feb 15.
1001 Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease.Mol Neurobiol. 2018 Dec;55(12):8936-8952. doi: 10.1007/s12035-018-1030-z. Epub 2018 Apr 4.
1002 Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease.Fluids Barriers CNS. 2019 Dec 17;16(1):38. doi: 10.1186/s12987-019-0158-1.
1003 Transient Mild Cerebral Ischemia Significantly Deteriorated Cognitive Impairment in a Mouse Model of Alzheimer's Disease via Angiotensin AT1 Receptor.Am J Hypertens. 2017 Feb;30(2):141-150. doi: 10.1093/ajh/hpw099. Epub 2016 Aug 29.
1004 Relevance of A42/40 Ratio for Detection of Alzheimer Disease Pathology in Clinical Routine: The PLM(R) Scale.Front Aging Neurosci. 2018 May 28;10:138. doi: 10.3389/fnagi.2018.00138. eCollection 2018.
1005 CSF synaptic protein concentrations are raised in those with atypical Alzheimer's disease but not frontotemporal dementia.Alzheimers Res Ther. 2019 Dec 17;11(1):105. doi: 10.1186/s13195-019-0564-2.
1006 Molecular Interaction of Anti-Diabetic Drugs With Acetylcholinesterase and Sodium Glucose Co-Transporter 2.J Cell Biochem. 2017 Nov;118(11):3855-3865. doi: 10.1002/jcb.26036. Epub 2017 May 23.
1007 Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus.Neuroscience. 2017 May 20;351:108-118. doi: 10.1016/j.neuroscience.2017.03.041. Epub 2017 Apr 4.
1008 Disturbed neurotransmitter transporter expression in Alzheimer's disease brain.J Alzheimers Dis. 2011;26(4):755-66. doi: 10.3233/JAD-2011-110002.
1009 System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40.J Neurosci. 2006 Mar 22;26(12):3345-56. doi: 10.1523/JNEUROSCI.5186-05.2006.
1010 Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes.Pharm Res. 2018 Nov 28;36(1):17. doi: 10.1007/s11095-018-2546-7.
1011 A 14bp indel variation in the NCX1 gene modulates the age at onset in late-onset Alzheimer's disease.J Neural Transm (Vienna). 2012 Mar;119(3):383-6. doi: 10.1007/s00702-011-0696-4. Epub 2011 Aug 11.
1012 Increased permeability of the blood-brain barrier and Alzheimer's disease-like alterations in slit-2 transgenic mice.J Alzheimers Dis. 2015;43(2):535-48. doi: 10.3233/JAD-141215.
1013 Genome-wide network-based pathway analysis of CSF t-tau/A1-42 ratio in the ADNI cohort.BMC Genomics. 2017 May 30;18(1):421. doi: 10.1186/s12864-017-3798-z.
1014 Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-.Chem Commun (Camb). 2019 May 21;55(42):5847-5850. doi: 10.1039/c9cc01005j.
1015 Sphingolipid metabolism correlates with cerebrospinal fluid Beta amyloid levels in Alzheimer's disease.PLoS One. 2015 May 4;10(5):e0125597. doi: 10.1371/journal.pone.0125597. eCollection 2015.
1016 SNARE Complex Polymorphisms Associate with Alterations of Visual Selective Attention in Alzheimer's Disease.J Alzheimers Dis. 2019;69(1):179-188. doi: 10.3233/JAD-190147.
1017 -Synuclein Induces Human Cortical Astrocyte Proliferation and Subsequent BDNF Expression and Release.Neuroscience. 2019 Jul 1;410:41-54. doi: 10.1016/j.neuroscience.2019.04.057. Epub 2019 May 10.
1018 The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.J Alzheimers Dis. 2019;68(4):1535-1547. doi: 10.3233/JAD-181116.
1019 Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.Nat Commun. 2018 Apr 16;9(1):1479. doi: 10.1038/s41467-018-03674-2.
1020 Sphingosine Kinase 2 Potentiates Amyloid Deposition but Protects against Hippocampal Volume Loss and Demyelination in a Mouse Model of Alzheimer's Disease.J Neurosci. 2019 Nov 27;39(48):9645-9659. doi: 10.1523/JNEUROSCI.0524-19.2019. Epub 2019 Oct 22.
1021 Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography-mass spectrometry targeted metabonomic profiling.Eur J Nutr. 2017 Feb;56(1):29-43. doi: 10.1007/s00394-015-1053-4. Epub 2015 Oct 1.
1022 Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies.J Exp Med. 2018 Dec 3;215(12):3038-3056. doi: 10.1084/jem.20180539. Epub 2018 Oct 29.
1023 Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease.Neurobiol Dis. 2019 Oct;130:104511. doi: 10.1016/j.nbd.2019.104511. Epub 2019 Jun 15.
1024 Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in -Amyloid Induced Toxicity.Mol Neurobiol. 2019 Jan;56(1):292-306. doi: 10.1007/s12035-018-1045-5. Epub 2018 Apr 26.
1025 Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease.Acta Neuropathol. 2015 Apr;129(4):541-63. doi: 10.1007/s00401-015-1394-3. Epub 2015 Feb 13.
1026 Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human A(1-42) and tau.Biochem Biophys Res Commun. 2012 Oct 12;427(1):218-22. doi: 10.1016/j.bbrc.2012.09.056. Epub 2012 Sep 17.
1027 The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to -amyloid peptide.J Biol Chem. 2017 Dec 15;292(50):20669-20682. doi: 10.1074/jbc.M117.792911. Epub 2017 Oct 20.
1028 Antibodies to Signaling Molecules and Receptors in Alzheimer's Disease are Associated with Psychomotor Slowing, Depression, and Poor Visuospatial Function.J Alzheimers Dis. 2017;59(3):929-939. doi: 10.3233/JAD-170245.
1029 Cerebrospinal Fluid Stanniocalcin-1 as a Biomarker for Alzheimer's Disease and Other Neurodegenerative Disorders.Neuromolecular Med. 2017 Mar;19(1):154-160. doi: 10.1007/s12017-016-8439-1. Epub 2016 Sep 19.
1030 Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.J Biol Chem. 2013 May 24;288(21):15418-29. doi: 10.1074/jbc.M112.448183. Epub 2013 Apr 12.
1031 SCG10-related neuronal growth-associated proteins in neural development, plasticity, degeneration, and aging.J Neurosci Res. 2002 Nov 1;70(3):264-73. doi: 10.1002/jnr.10353.
1032 Microglia-derived ASC specks cross-seed amyloid- in Alzheimer's disease.Nature. 2017 Dec 20;552(7685):355-361. doi: 10.1038/nature25158.
1033 Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease.PLoS One. 2014 May 1;9(5):e94576. doi: 10.1371/journal.pone.0094576. eCollection 2014.
1034 No association of Tachykinin receptor 2 (TACR2) polymorphisms with Alzheimer's disease.Neurobiol Aging. 2011 Mar;32(3):544-5. doi: 10.1016/j.neurobiolaging.2009.03.007. Epub 2009 Apr 18.
1035 Gene mutations in a Han Chinese Alzheimer's disease cohort.Brain Behav. 2019 Jan;9(1):e01180. doi: 10.1002/brb3.1180. Epub 2018 Dec 14.
1036 Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results.J Alzheimers Dis. 2019;71(1):261-271. doi: 10.3233/JAD-190620.
1037 Systematic Analysis and Biomarker Study for Alzheimer's Disease.Sci Rep. 2018 Nov 26;8(1):17394. doi: 10.1038/s41598-018-35789-3.
1038 Expression of tryptophan 2,3-dioxygenase and production of kynurenine pathway metabolites in triple transgenic mice and human Alzheimer's disease brain.PLoS One. 2013 Apr 22;8(4):e59749. doi: 10.1371/journal.pone.0059749. Print 2013.
1039 Blood-Based Oligomeric and Other Protein Variant Biomarkers to Facilitate Pre-Symptomatic Diagnosis and Staging of Alzheimer's Disease.J Alzheimers Dis. 2017;58(1):23-35. doi: 10.3233/JAD-161116.
1040 Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.Neurol Res. 2019 Jun;41(6):504-509. doi: 10.1080/01616412.2019.1580456. Epub 2019 Feb 14.
1041 Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease.Neurobiol Aging. 2012 Aug;33(8):1633-41. doi: 10.1016/j.neurobiolaging.2011.03.005. Epub 2011 Apr 21.
1042 Genomics of Alzheimer Disease: A Review.JAMA Neurol. 2016 Jul 1;73(7):867-74. doi: 10.1001/jamaneurol.2016.0301.
1043 Transferrin Receptor-Mediated Uptake at the Blood-Brain Barrier Is Not Impaired by Alzheimer's Disease Neuropathology.Mol Pharm. 2019 Feb 4;16(2):583-594. doi: 10.1021/acs.molpharmaceut.8b00870. Epub 2019 Jan 17.
1044 Increased Transforming Growth Factor 2 in the Neocortex of Alzheimer's Disease and Dementia with Lewy Bodies isCorrelated with Disease Severity andSoluble A42 Load.J Alzheimers Dis. 2017;56(1):157-166. doi: 10.3233/JAD-160781.
1045 Altered expression of transforming growth factor-beta in Alzheimer's disease.Neurology. 1995 Aug;45(8):1561-9. doi: 10.1212/wnl.45.8.1561.
1046 A functional variant in the miR-142 promoter modulating its expression and conferring risk of Alzheimer disease.Hum Mutat. 2019 Nov;40(11):2131-2145. doi: 10.1002/humu.23872. Epub 2019 Aug 7.
1047 Effect of Some Growth Factors on Tissue Transglutaminase Overexpression Induced by -Amyloid in Olfactory Ensheathing Cells.Mol Neurobiol. 2017 Nov;54(9):6785-6794. doi: 10.1007/s12035-016-0152-4. Epub 2016 Oct 18.
1048 Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.Aging (Albany NY). 2019 Sep 11;11(17):7257-7273. doi: 10.18632/aging.102260. Epub 2019 Sep 11.
1049 Intramembrane attenuation of the TLR4-TLR6 dimer impairs receptor assembly and reduces microglia-mediated neurodegeneration.J Biol Chem. 2017 Aug 11;292(32):13415-13427. doi: 10.1074/jbc.M117.784983. Epub 2017 Jun 27.
1050 A phase 1 clinical trial of the sigma-2 receptor complex allosteric antagonist CT1812, a novel therapeutic candidate for Alzheimer's disease.Alzheimers Dement (N Y). 2019 Jan 23;5:20-26. doi: 10.1016/j.trci.2018.11.001. eCollection 2019.
1051 Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle.Neural Regen Res. 2019 Jul;14(7):1144-1147. doi: 10.4103/1673-5374.247443.
1052 Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer's Disease.Front Neurosci. 2019 Feb 4;13:49. doi: 10.3389/fnins.2019.00049. eCollection 2019.
1053 Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein.J Biol Chem. 2012 Aug 17;287(34):29125-33. doi: 10.1074/jbc.M112.362038. Epub 2012 Jul 3.
1054 Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.Mol Neurobiol. 2018 May;55(5):4333-4344. doi: 10.1007/s12035-017-0547-x. Epub 2017 Jun 19.
1055 High-sensitivity cardiac troponin I and NT-proBNP as predictors of incident dementia and Alzheimer's disease: the FINRISK Study.J Neurol. 2017 Mar;264(3):503-511. doi: 10.1007/s00415-016-8378-7. Epub 2016 Dec 30.
1056 Aberrant Accumulation of BRCA1 in Alzheimer Disease and Other Tauopathies.J Neuropathol Exp Neurol. 2020 Jan 1;79(1):22-33. doi: 10.1093/jnen/nlz107.
1057 Genetic risk factors for depression in Alzheimer`s disease patients.Curr Alzheimer Res. 2013 Jan;10(1):72-81.
1058 Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice.Curr Alzheimer Res. 2019;16(3):219-232. doi: 10.2174/1567205016666190301110110.
1059 Increased brain lysosomal pepstatin-insensitive proteinase activity in patients with neurodegenerative diseases.Neurosci Lett. 1999 Apr 2;264(1-3):157-60. doi: 10.1016/s0304-3940(99)00095-6.
1060 The small chaperone protein p23 and its cleaved product p19 in cellular stress.J Mol Neurosci. 2012 Feb;46(2):303-14. doi: 10.1007/s12031-011-9574-7. Epub 2011 Jun 21.
1061 Common Variant in TREM1 Influencing Brain Amyloid Deposition in Mild Cognitive Impairment and Alzheimer's Disease.Neurotox Res. 2020 Mar;37(3):661-668. doi: 10.1007/s12640-019-00105-y. Epub 2019 Nov 13.
1062 Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain.Angew Chem Int Ed Engl. 2019 Sep 23;58(39):13948-13953. doi: 10.1002/anie.201907210. Epub 2019 Aug 14.
1063 TRPC1 Null Exacerbates Memory Deficit and Apoptosis Induced by Amyloid-.J Alzheimers Dis. 2018;63(2):761-772. doi: 10.3233/JAD-180077.
1064 Multiple molecular mechanisms form a positive feedback loop driving amyloid 42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons.Cell Death Dis. 2018 Feb 7;9(2):195. doi: 10.1038/s41419-018-0270-1.
1065 Activation of transient receptor potential melastatin 7 (TRPM7) channel increases basal autophagy and reduces amyloid -peptide.Biochem Biophys Res Commun. 2017 Nov 4;493(1):494-499. doi: 10.1016/j.bbrc.2017.08.163. Epub 2017 Sep 1.
1066 Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging.JAMA Neurol. 2019 Nov 1;76(11):1340-1351. doi: 10.1001/jamaneurol.2019.2462.
1067 Immunohistochemistry and in situ hybridization of T-cell acute lymphoblastic leukemia-associated antigen 1 in human brain tissues.Dement Geriatr Cogn Disord. 1999 Mar-Apr;10(2):59-63. doi: 10.1159/000017102.
1068 miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3 in Alzheimer's disease.J Cell Biochem. 2019 Jun;120(6):9936-9946. doi: 10.1002/jcb.28276. Epub 2018 Dec 16.
1069 Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease.Free Radic Biol Med. 2019 Apr;134:567-580. doi: 10.1016/j.freeradbiomed.2019.02.010. Epub 2019 Feb 12.
1070 Thioredoxin-Interacting Protein (TXNIP) Associated NLRP3 Inflammasome Activation in Human Alzheimer's Disease Brain.J Alzheimers Dis. 2019;68(1):255-265. doi: 10.3233/JAD-180814.
1071 Geographical Distribution and Diversity of Gut Microbial NADH:Ubiquinone Oxidoreductase Sequence Associated with Alzheimer's Disease.J Alzheimers Dis. 2018;61(4):1531-1540. doi: 10.3233/JAD-170764.
1072 Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts.Chem Biodivers. 2019 Sep;16(9):e1900333. doi: 10.1002/cbdv.201900333. Epub 2019 Aug 8.
1073 Neuropathological findings in cerebral B-protein amyloidosis. Differences and similarities in those cases presenting as a cerebral hemorrhage and those presenting as a dementia of the Alzheimer type.Clin Neurol Neurosurg. 1992;94 Suppl:S52-3. doi: 10.1016/0303-8467(92)90021-t.
1074 Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1E9 mouse model of Alzheimer's disease.Hum Mol Genet. 2017 Oct 15;26(20):4042-4054. doi: 10.1093/hmg/ddx295.
1075 Deletion of Specific Sphingolipids in Distinct Neurons Improves Spatial Memory in a Mouse Model of Alzheimer's Disease.Front Mol Neurosci. 2018 Jun 20;11:206. doi: 10.3389/fnmol.2018.00206. eCollection 2018.
1076 USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells.Sci Rep. 2019 Jul 22;9(1):10591. doi: 10.1038/s41598-019-47033-7.
1077 Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease.J Alzheimers Dis. 2019;72(2):425-441. doi: 10.3233/JAD-190635.
1078 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1157-1170.
1079 Gender-Specific Expression of Ubiquitin-Specific Peptidase 9 Modulates Tau Expression and Phosphorylation: Possible Implications for Tauopathies.Mol Neurobiol. 2017 Dec;54(10):7979-7993. doi: 10.1007/s12035-016-0299-z. Epub 2016 Nov 23.
1080 Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid Toxicity: Relevance to Alzheimer's Disease.Mol Neurobiol. 2020 Mar;57(3):1374-1388. doi: 10.1007/s12035-019-01819-y. Epub 2019 Nov 16.
1081 A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders.Aging Clin Exp Res. 2020 Jan;32(1):21-27. doi: 10.1007/s40520-019-01135-4. Epub 2019 Mar 12.
1082 WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by A oligomers.Exp Neurol. 2015 Feb;264:14-25. doi: 10.1016/j.expneurol.2014.11.005. Epub 2014 Nov 20.
1083 Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts.J Alzheimers Dis. 2015;45(3):851-64. doi: 10.3233/JAD-142214.
1084 Network-Driven Proteogenomics Unveils an Aging-Related Imbalance in the Olfactory IB-NFB p65 Complex Functionality in Tg2576 Alzheimer's Disease Mouse Model.Int J Mol Sci. 2017 Oct 27;18(11):2260. doi: 10.3390/ijms18112260.
1085 Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders.PLoS One. 2017 Jul 26;12(7):e0180319. doi: 10.1371/journal.pone.0180319. eCollection 2017.
1086 Suppression of lncRNA-ATB prevents amyloid--induced neurotoxicity in PC12 cells via regulating miR-200/ZNF217 axis.Biomed Pharmacother. 2018 Dec;108:707-715. doi: 10.1016/j.biopha.2018.08.155. Epub 2018 Sep 21.
1087 Intermediate phenotypes identify divergent pathways to Alzheimer's disease.PLoS One. 2010 Jun 21;5(6):e11244. doi: 10.1371/journal.pone.0011244.
1088 Pericyte-derived bone morphogenetic protein 4 underlies white matter damage after chronic hypoperfusion.Brain Pathol. 2018 Jul;28(4):521-535. doi: 10.1111/bpa.12523. Epub 2017 May 31.
1089 Molecular Insights into NR4A2(Nurr1): an Emerging Target for Neuroprotective Therapy Against Neuroinflammation and Neuronal Cell Death.Mol Neurobiol. 2019 Aug;56(8):5799-5814. doi: 10.1007/s12035-019-1487-4. Epub 2019 Jan 25.
1090 BARHL1 Is Downregulated in Alzheimer's Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways.Genes (Basel). 2017 Sep 28;8(10):245. doi: 10.3390/genes8100245.
1091 Lipoprotein-associated phospholipase A2: The story continues.Med Res Rev. 2020 Jan;40(1):79-134. doi: 10.1002/med.21597. Epub 2019 May 29.
1092 Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain.Neuroscience. 2006 Jul 7;140(3):879-88. doi: 10.1016/j.neuroscience.2006.02.049. Epub 2006 Apr 3.
1093 Correcting miR92a-vGAT-Mediated GABAergic Dysfunctions Rescues Human Tau-Induced Anxiety in Mice.Mol Ther. 2017 Jan 4;25(1):140-152. doi: 10.1016/j.ymthe.2016.10.010. Epub 2017 Jan 4.
1094 The Alu-rich genomic architecture of SPAST predisposes to diverse and functionally distinct disease-associated CNV alleles.Am J Hum Genet. 2014 Aug 7;95(2):143-61. doi: 10.1016/j.ajhg.2014.06.014. Epub 2014 Jul 24.
1095 ATP Binding Cassette Subfamily A Member 2 (ABCA2) Expression and Methylation are Associated with Alzheimer's Disease. Med Sci Monit. 2017 Dec 10;23:5851-5861.
1096 Bridging the Gap between Alzheimer's Disease and Alzheimer's-like Diseases in Animals.Int J Mol Sci. 2019 Apr 3;20(7):1664. doi: 10.3390/ijms20071664.
1097 Wilson's disease and other neurological copper disorders.Lancet Neurol. 2015 Jan;14(1):103-13. doi: 10.1016/S1474-4422(14)70190-5.
1098 Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.Neurosci Lett. 2005 Feb 10;374(2):124-8. doi: 10.1016/j.neulet.2004.10.038.
1099 Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease.Anat Rec (Hoboken). 2019 Feb;302(2):332-338. doi: 10.1002/ar.23969. Epub 2018 Nov 9.
1100 Chromosome 8p as a potential hub for developmental neuropsychiatric disorders: implications for schizophrenia, autism and cancer.Mol Psychiatry. 2009 Jun;14(6):563-89. doi: 10.1038/mp.2009.2. Epub 2009 Feb 10.
1101 Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression.J Alzheimers Dis. 2017;55(2):763-776. doi: 10.3233/JAD-160330.
1102 Reduced CaM Kinase II and CaM Kinase IV Activities Underlie Cognitive Deficits in NCKX2 Heterozygous Mice.Mol Neurobiol. 2018 May;55(5):3889-3900. doi: 10.1007/s12035-017-0596-1. Epub 2017 May 25.
1103 Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype.JAMA Neurol. 2019 Sep 1;76(9):1099-1108. doi: 10.1001/jamaneurol.2019.1456.
1104 Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population.Rejuvenation Res. 2013 Feb;16(1):57-66. doi: 10.1089/rej.2012.1381.
1105 Housefly (Musca domestica) larvae powder, preventing oxidative stress injury via regulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice.Food Funct. 2019 Jan 22;10(1):235-243. doi: 10.1039/c8fo02052c.
1106 Mitoferrin-1 is Involved in the Progression of Alzheimer's Disease Through Targeting Mitochondrial Iron Metabolism in a Caenorhabditis elegans Model of Alzheimer's Disease.Neuroscience. 2018 Aug 10;385:90-101. doi: 10.1016/j.neuroscience.2018.06.011. Epub 2018 Jun 13.
1107 Appoptosin Mediates Lesions Induced by Oxidative Stress Through the JNK-FoxO1 Pathway.Front Aging Neurosci. 2019 Sep 4;11:243. doi: 10.3389/fnagi.2019.00243. eCollection 2019.
1108 MSUT2 is a determinant of susceptibility to tau neurotoxicity.Hum Mol Genet. 2011 May 15;20(10):1989-99. doi: 10.1093/hmg/ddr079. Epub 2011 Feb 25.
1109 Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population.J Mol Neurosci. 2012 Jul;47(3):481-4. doi: 10.1007/s12031-012-9748-y. Epub 2012 Mar 16.
1110 Transcript Analysis of Zebrafish GLUT3 Genes, slc2a3a and slc2a3b, Define Overlapping as Well as Distinct Expression Domains in the Zebrafish (Danio rerio) Central Nervous System.Front Mol Neurosci. 2019 Aug 27;12:199. doi: 10.3389/fnmol.2019.00199. eCollection 2019.
1111 Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.J Alzheimers Dis. 2013;34(2):399-405. doi: 10.3233/JAD-121621.
1112 Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain.Transl Psychiatry. 2016 Jun 14;6(6):e838. doi: 10.1038/tp.2016.83.
1113 Altered expression of ZnT10 in Alzheimer's disease brain.PLoS One. 2013 May 31;8(5):e65475. doi: 10.1371/journal.pone.0065475. Print 2013.
1114 Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates A42-induced Alzheimer's disease-like symptoms.Neurobiol Aging. 2013 Nov;34(11):2604-12. doi: 10.1016/j.neurobiolaging.2013.05.029. Epub 2013 Jul 2.
1115 Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.J Alzheimers Dis. 2010;20(2):465-75. doi: 10.3233/JAD-2010-1385.
1116 Clinical effectiveness of rivastigmine monotherapy and combination therapy in Alzheimer's patients.CNS Neurosci Ther. 2013 Feb;19(2):91-7. doi: 10.1111/cns.12036. Epub 2012 Dec 4.
1117 A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease.J Alzheimers Dis. 2019;71(4):1163-1174. doi: 10.3233/JAD-190700.
1118 Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease.J Neuroinflammation. 2008 Aug 20;5:36. doi: 10.1186/1742-2094-5-36.
1119 Histone deacetylase-mediated regulation of endolysosomal pH.J Biol Chem. 2018 May 4;293(18):6721-6735. doi: 10.1074/jbc.RA118.002025. Epub 2018 Mar 22.
1120 Differential expression of cholesterol hydroxylases in Alzheimer's disease. J Biol Chem. 2004 Aug 13;279(33):34674-81. doi: 10.1074/jbc.M402324200. Epub 2004 May 17.
1121 Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease.PLoS One. 2017 Jan 6;12(1):e0167273. doi: 10.1371/journal.pone.0167273. eCollection 2017.
1122 Preclinical Development of Crocus sativus-Based Botanical Lead IIIM-141 for Alzheimer's Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology.ACS Omega. 2018 Aug 20;3(8):9572-9585. doi: 10.1021/acsomega.8b00841. eCollection 2018 Aug 31.
1123 Alcohol Dehydrogenase 1B Suppresses -Amyloid-Induced Neuron Apoptosis.Front Aging Neurosci. 2019 Jun 5;11:135. doi: 10.3389/fnagi.2019.00135. eCollection 2019.
1124 Hypertension accelerates cerebral tissue PO(2) disruption in Alzheimer's disease.Neurosci Lett. 2020 Jan 10;715:134626. doi: 10.1016/j.neulet.2019.134626. Epub 2019 Nov 11.
1125 Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease.J Neurosci. 2011 Feb 9;31(6):2313-20. doi: 10.1523/JNEUROSCI.4717-10.2011.
1126 Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease.J Alzheimers Dis. 2019;68(1):33-38. doi: 10.3233/JAD-181043.
1127 Sensitive electrochemical detection of amyloid beta peptide in human serum using an interdigitated chain-shaped electrode.Biosens Bioelectron. 2019 Nov 1;144:111694. doi: 10.1016/j.bios.2019.111694. Epub 2019 Sep 7.
1128 Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer's disease.Neuroscience. 2003;121(2):307-14. doi: 10.1016/s0306-4522(03)00438-x.
1129 Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.PLoS Genet. 2014 Oct 23;10(10):e1004758. doi: 10.1371/journal.pgen.1004758. eCollection 2014 Oct.
1130 Asymmetric dimethylarginine exacerbates A-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.Free Radic Biol Med. 2015 Feb;79:117-26. doi: 10.1016/j.freeradbiomed.2014.12.002. Epub 2014 Dec 12.
1131 Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity.Exp Neurol. 2019 Jul;317:51-65. doi: 10.1016/j.expneurol.2019.02.014. Epub 2019 Feb 26.
1132 Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease.Biochem Pharmacol. 2018 Nov;157:202-209. doi: 10.1016/j.bcp.2018.09.009. Epub 2018 Sep 6.
1133 Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer's Disease.Front Cell Neurosci. 2019 Jun 28;13:264. doi: 10.3389/fncel.2019.00264. eCollection 2019.
1134 Unveiling the olfactory proteostatic disarrangement in Parkinson's disease by proteome-wide profiling.Neurobiol Aging. 2019 Jan;73:123-134. doi: 10.1016/j.neurobiolaging.2018.09.018. Epub 2018 Sep 25.
1135 Alterations in Serum Zinc and Polyunsaturated Fatty Acid Concentrations in Treatment-Naive HIV-Diagnosed Alcohol-Dependent Subjects with Liver Injury.AIDS Res Hum Retroviruses. 2019 Jan;35(1):92-99. doi: 10.1089/AID.2018.0124. Epub 2018 Dec 11.
1136 Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients.Nutrients. 2019 Jul 31;11(8):1764. doi: 10.3390/nu11081764.
1137 H- and C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.J Neural Transm (Vienna). 2015 Apr;122(4):541-50. doi: 10.1007/s00702-015-1387-3. Epub 2015 Mar 6.
1138 Metabolomic Assays of Postmortem Brain Extracts: Pitfalls in Extrapolation of Concentrations of Glucose and Amino Acids to Metabolic Dysregulation In Vivo in Neurological Diseases.Neurochem Res. 2019 Oct;44(10):2239-2260. doi: 10.1007/s11064-018-2611-y. Epub 2018 Aug 16.
1139 Behavioral stress causes mitochondrial dysfunction via ABAD up-regulation and aggravates plaque pathology in the brain of a mouse model of Alzheimer disease.Free Radic Biol Med. 2011 Jun 1;50(11):1526-35. doi: 10.1016/j.freeradbiomed.2011.02.035. Epub 2011 Mar 5.
1140 Histopathological features of a patient with Charcot-Marie-Tooth disease type 2U/AD-CMTax-MARS.J Peripher Nerv Syst. 2016 Dec;21(4):370-374. doi: 10.1111/jns.12193.
1141 Regulation of methionine adenosyltransferase catalytic activity and messenger RNA in SH-SY5Y human neuroblastoma cells.Biochem Pharmacol. 1998 Mar 1;55(5):567-71. doi: 10.1016/s0006-2952(97)00514-5.
1142 Degradation of amyloid beta by human induced pluripotent stem cell-derived macrophages expressing Neprilysin-2.Stem Cell Res. 2014 Nov;13(3 Pt A):442-53. doi: 10.1016/j.scr.2014.10.001. Epub 2014 Oct 12.
1143 Oxidation of methionine 35 reduces toxicity of the amyloid beta-peptide(1-42) in neuroblastoma cells (IMR-32) via enzyme methionine sulfoxide reductase A expression and function.Neurochem Int. 2010 Mar;56(4):597-602. doi: 10.1016/j.neuint.2010.01.002. Epub 2010 Jan 11.
1144 Mitochondrial methionine sulfoxide reductase B2 links oxidative stress to Alzheimer's disease-like pathology.Exp Neurol. 2019 Aug;318:145-156. doi: 10.1016/j.expneurol.2019.05.006. Epub 2019 May 9.
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1146 NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant.BMC Med Genet. 2004 Mar 17;5:6. doi: 10.1186/1471-2350-5-6.
1147 The role of NAT2 gene polymorphism in aetiology of the most frequent neurodegenerative diseases with dementia.Neurol Neurochir Pol. 2007 Sep-Oct;41(5):388-94.
1148 Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces -secretase (BACE1) levels and A generation.J Biol Chem. 2012 Mar 9;287(11):8424-33. doi: 10.1074/jbc.M111.310136. Epub 2012 Jan 20.
1149 NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.Behav Brain Res. 2018 Feb 26;339:140-152. doi: 10.1016/j.bbr.2017.11.030. Epub 2017 Nov 23.
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1151 Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.J Nutr Biochem. 2019 May;67:123-137. doi: 10.1016/j.jnutbio.2019.01.015. Epub 2019 Feb 11.
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1153 Polymorphisms of the cholesterol 24-hydroxylase (CYP46A1) gene and the risk of Alzheimer's disease in a Chinese population.Int Psychogeriatr. 2006 Mar;18(1):37-45. doi: 10.1017/S1041610205003108.
1154 Abnormal circadian locomotor rhythms and Per gene expression in six-month-old triple transgenic mice model of Alzheimer's disease.Neurosci Lett. 2018 May 29;676:13-18. doi: 10.1016/j.neulet.2018.04.008. Epub 2018 Apr 4.
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1156 Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.Neurobiol Aging. 2012 May;33(5):1015.e7-23. doi: 10.1016/j.neurobiolaging.2010.08.003. Epub 2010 Oct 27.
1157 An aberrant protein complex in CSF as a biomarker of Alzheimer disease.Neurology. 2008 Jun 3;70(23):2212-8. doi: 10.1212/01.wnl.0000312383.39973.88. Epub 2008 Apr 30.
1158 Nicotine versus 6-hydroxy-l-nicotine against chlorisondamine induced memory impairment and oxidative stress in the rat hippocampus.Biomed Pharmacother. 2017 Feb;86:102-108. doi: 10.1016/j.biopha.2016.12.008. Epub 2016 Dec 9.
1159 Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases.Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2264-2274. doi: 10.1167/iovs.17-23678.
1160 Neurofibrillary degeneration in Alzheimer's disease: from molecular mechanisms to identification of drug targets.Curr Opin Psychiatry. 2008 Nov;21(6):555-61. doi: 10.1097/YCO.0b013e328314b78b.
1161 Mapping and molecular characterization of novel monoclonal antibodies to conformational epitopes on NH2 and COOH termini of mammalian tryptophanyl-tRNA synthetase reveal link of the epitopes to aggregation and Alzheimer's disease.Mol Immunol. 2007 Jan;44(4):541-57. doi: 10.1016/j.molimm.2006.02.006. Epub 2006 Apr 17.
1162 Frameshift proteins in autosomal dominant forms of Alzheimer disease and other tauopathies.Neurology. 2006 Jan 24;66(2 Suppl 1):S86-92. doi: 10.1212/01.wnl.0000193882.46003.6d.
1163 Diagnostics and Treatments of Iron-Related CNS Diseases.Adv Exp Med Biol. 2019;1173:179-194. doi: 10.1007/978-981-13-9589-5_10.
1164 Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies.Front Aging Neurosci. 2018 Apr 26;10:122. doi: 10.3389/fnagi.2018.00122. eCollection 2018.
1165 Liquid biopsy of cerebrospinal fluid identifies neuronal pentraxin receptor (NPTXR) as a biomarker of progression of Alzheimer's disease.Clin Chem Lab Med. 2019 Nov 26;57(12):1875-1881. doi: 10.1515/cclm-2019-0428.
1166 The Cingulate Island Sign on FDG-PET vs. IMP-SPECT to Assess Mild Cognitive Impairment in Alzheimer's Disease vs. Dementia with Lewy Bodies.J Neuroimaging. 2019 Nov;29(6):712-720. doi: 10.1111/jon.12643. Epub 2019 Jun 14.
1167 Astaxanthin exerts protective effects similar to bexarotene in Alzheimer's disease by modulating amyloid-beta and cholesterol homeostasis in blood-brain barrier endothelial cells.Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2224-2245. doi: 10.1016/j.bbadis.2019.04.019. Epub 2019 May 2.
1168 Age, but Not Amyloidosis, Induced Changes in Global Levels of Histone Modifications in Susceptible and Disease-Resistant Neurons in Alzheimer's Disease Model Mice.Front Aging Neurosci. 2019 Apr 3;11:68. doi: 10.3389/fnagi.2019.00068. eCollection 2019.
1169 Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration.J Alzheimers Dis. 2018;61(4):1477-1483. doi: 10.3233/JAD-170722.
1170 Association between selected cholesterol-related gene polymorphisms and Alzheimer's disease in a Turkish cohort.Mol Biol Rep. 2019 Apr;46(2):1701-1707. doi: 10.1007/s11033-019-04619-8. Epub 2019 Jan 25.
1171 Association of COL25A1 with comorbid antisocial personality disorder and substance dependence.Biol Psychiatry. 2012 Apr 15;71(8):733-40. doi: 10.1016/j.biopsych.2011.12.011. Epub 2012 Jan 31.
1172 CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients.Neurobiol Aging. 2017 Nov;59:1-9. doi: 10.1016/j.neurobiolaging.2017.06.028. Epub 2017 Jul 11.
1173 A Role for SERCA Pumps in the Neurobiology of Neuropsychiatric and Neurodegenerative Disorders.Adv Exp Med Biol. 2020;1131:131-161. doi: 10.1007/978-3-030-12457-1_6.
1174 NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models.Autophagy. 2017;13(12):2028-2040. doi: 10.1080/15548627.2017.1379633.
1175 Transcriptomic and Network Analysis Highlight the Association of Diabetes at Different Stages of Alzheimer's Disease.Front Neurosci. 2019 Nov 29;13:1273. doi: 10.3389/fnins.2019.01273. eCollection 2019.
1176 Genetic variation associated with the occurrence and progression of neurological disorders.Neurotoxicology. 2017 Jul;61:243-264. doi: 10.1016/j.neuro.2016.09.018. Epub 2016 Oct 3.
1177 Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.J Neuropathol Exp Neurol. 2011 Apr;70(4):264-80. doi: 10.1097/NEN.0b013e318211c86a.
1178 Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.Structure. 2018 Aug 7;26(8):1137-1143.e3. doi: 10.1016/j.str.2018.05.008. Epub 2018 Jun 28.
1179 In Silico Insights towards the Identification of NLRP3 Druggable Hot Spots.Int J Mol Sci. 2019 Oct 9;20(20):4974. doi: 10.3390/ijms20204974.
1180 Generation of induced pluripotent stem cell line (ZZUi0013-A) from a 65-year-old patient with a novel MEOX2 gene mutation in Alzheimer's disease.Stem Cell Res. 2019 Jan;34:101366. doi: 10.1016/j.scr.2018.101366. Epub 2018 Dec 27.
1181 Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease.Transl Psychiatry. 2014 Jun 10;4(6):e396. doi: 10.1038/tp.2014.35.
1182 Enhanced amyloid- generation by -secretase complex in DRM microdomains with reduced cholesterol levels.Hum Mol Genet. 2020 Feb 1;29(3):382-393. doi: 10.1093/hmg/ddz297.
1183 Transethnic genome-wide scan identifies novel Alzheimer's disease loci.Alzheimers Dement. 2017 Jul;13(7):727-738. doi: 10.1016/j.jalz.2016.12.012. Epub 2017 Feb 7.
1184 NLRP12 autoinflammatory disease: a Chinese case series and literature review.Clin Rheumatol. 2017 Jul;36(7):1661-1667. doi: 10.1007/s10067-016-3410-y. Epub 2016 Sep 16.
1185 Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson's, Alzheimer's and ALS disease.BMC Med Genomics. 2019 May 9;12(1):60. doi: 10.1186/s12920-019-0509-4.
1186 Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.Neurosci Lett. 2009 Sep 11;461(1):54-9. doi: 10.1016/j.neulet.2009.05.051. Epub 2009 May 27.
1187 Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia.Adv Sci (Weinh). 2018 Dec 12;6(4):1801586. doi: 10.1002/advs.201801586. eCollection 2019 Feb 20.
1188 Inhibition of casein kinase 1/improves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer's disease.Sci Rep. 2019 Sep 24;9(1):13743. doi: 10.1038/s41598-019-50197-x.
1189 Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia?.Neurochem Int. 2018 Sep;118:134-144. doi: 10.1016/j.neuint.2018.04.004. Epub 2018 Apr 10.
1190 PLA2G6 accumulates in Lewy bodies in PARK14 and idiopathic Parkinson's disease.Neurosci Lett. 2017 Apr 3;645:40-45. doi: 10.1016/j.neulet.2017.02.027. Epub 2017 Feb 14.
1191 Expression patterns of prune2 is regulated by Notch and retinoic acid signaling pathways in the zebrafish embryogenesis.Gene Expr Patterns. 2017 Jan;23-24:45-51. doi: 10.1016/j.gep.2017.03.002. Epub 2017 Mar 11.
1192 Dysregulation of Rab5-mediated endocytic pathways in Alzheimer's disease.Traffic. 2018 Apr;19(4):253-262. doi: 10.1111/tra.12547. Epub 2018 Feb 5.
1193 Reducing ADAMTS-3 Inhibits Amyloid Deposition in App Knock-in Mouse.Biol Pharm Bull. 2019;42(3):354-356. doi: 10.1248/bpb.b18-00899.
1194 A photoelectrochemical sandwich immunoassay for protein S100, a biomarker for Alzheimer's disease, using an ITO electrode modified with a reduced graphene oxide-gold conjugate and CdS-labeled secondary antibody.Mikrochim Acta. 2019 Jan 16;186(2):117. doi: 10.1007/s00604-018-3159-x.
1195 Glucocerebrosidase regulators SCARB2 and TFEB are up-regulated in Lewy body disease brain.Neurosci Lett. 2019 Jul 27;706:164-168. doi: 10.1016/j.neulet.2019.05.034. Epub 2019 May 19.
1196 Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?.J Mol Neurosci. 2019 Oct;69(2):343-350. doi: 10.1007/s12031-019-01363-3. Epub 2019 Jul 2.
1197 SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments.Acta Neuropathol Commun. 2019 Feb 15;7(1):21. doi: 10.1186/s40478-019-0663-0.
1198 Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer's Disease.ACS Chem Neurosci. 2019 Oct 16;10(10):4199-4212. doi: 10.1021/acschemneuro.9b00460. Epub 2019 Sep 30.
1199 Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1.Acta Neuropathol Commun. 2016 Feb 25;4:16. doi: 10.1186/s40478-016-0282-y.
1200 Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid- Associated Neurotoxicity.J Alzheimers Dis. 2020;73(2):695-705. doi: 10.3233/JAD-190695.
1201 A pectin from fruits of Lycium barbarum L. decreases -amyloid peptide production through modulating APP processing.Carbohydr Polym. 2018 Dec 1;201:65-74. doi: 10.1016/j.carbpol.2018.08.050. Epub 2018 Aug 15.
1202 Down-regulated TMED10 in Alzheimer disease induces autophagy via ATG4B activation.Autophagy. 2019 Sep;15(9):1495-1505. doi: 10.1080/15548627.2019.1586249. Epub 2019 Mar 19.
1203 TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer's Disease.J Alzheimers Dis. 2017;58(4):1027-1033. doi: 10.3233/JAD-170190.
1204 Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial.JAMA Neurol. 2020 Feb 1;77(2):215-224. doi: 10.1001/jamaneurol.2019.3812.
1205 ADAMTS-4 in central nervous system pathologies.J Neurosci Res. 2017 Sep;95(9):1703-1711. doi: 10.1002/jnr.24021. Epub 2017 Jan 13.
1206 MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2.Brain Res. 2012 May 21;1455:103-13. doi: 10.1016/j.brainres.2011.10.051. Epub 2011 Nov 4.
1207 The relationship between four GWAS-identified loci in Alzheimer's disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy.Neurosci Lett. 2018 Nov 1;686:205-210. doi: 10.1016/j.neulet.2018.08.024. Epub 2018 Aug 22.
1208 Neuronal susceptibility to beta-amyloid toxicity and ischemic injury involves histone deacetylase-2 regulation of endophilin-B1.Brain Pathol. 2019 Mar;29(2):164-175. doi: 10.1111/bpa.12647. Epub 2018 Oct 5.
1209 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.Nat Genet. 2011 May;43(5):436-41. doi: 10.1038/ng.801. Epub 2011 Apr 3.
1210 Presenilin Mutation Suppresses Lung Tumorigenesis via Inhibition of Peroxiredoxin 6 Activity and Expression.Theranostics. 2017 Sep 1;7(15):3624-3637. doi: 10.7150/thno.21408. eCollection 2017.
1211 Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies.Acta Neuropathol Commun. 2019 Dec 3;7(1):195. doi: 10.1186/s40478-019-0848-6.
1212 Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level.Mol Neurobiol. 2018 Mar;55(3):2524-2546. doi: 10.1007/s12035-017-0494-6. Epub 2017 Apr 11.
1213 Alternative Splicing of Alpha- and Beta-Synuclein Genes Plays Differential Roles in Synucleinopathies.Genes (Basel). 2018 Jan 25;9(2):63. doi: 10.3390/genes9020063.
1214 Removing dysfunctional mitochondria from axons independent of mitophagy under pathophysiological conditions.Autophagy. 2017 Oct 3;13(10):1792-1794. doi: 10.1080/15548627.2017.1356552. Epub 2017 Aug 16.
1215 Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res. 2004 Oct 1;64(19):7156-68. doi: 10.1158/0008-5472.CAN-04-1121.
1216 Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.Cell Rep. 2018 Jun 5;23(10):2967-2975. doi: 10.1016/j.celrep.2018.05.011.
1217 Cross-interaction of tau PET tracers with monoamine oxidase B: evidence from in silico modelling and in vivo imaging.Eur J Nucl Med Mol Imaging. 2019 Jun;46(6):1369-1382. doi: 10.1007/s00259-019-04305-8. Epub 2019 Mar 27.
1218 The Adaptor Protein Alix is Involved in the Interaction Between the Ubiquitin Ligase NEDD4-1 and its Targets, ABCG1 and ABCG4.Int J Mol Sci. 2019 Jun 2;20(11):2714. doi: 10.3390/ijms20112714.
1219 Potential roles of PINK1 for increased PGC-1-mediated mitochondrial fatty acid oxidation and their associations with Alzheimer disease and diabetes.Mitochondrion. 2014 Sep;18:41-8. doi: 10.1016/j.mito.2014.09.005. Epub 2014 Sep 23.
1220 Translational study of Alzheimer's disease (AD) biomarkers from brain tissues in APP/PS1 mice and serum of AD patients.J Alzheimers Dis. 2015;45(1):269-82. doi: 10.3233/JAD-142805.
1221 Association of Parkinson's Disease GWAS-Linked Loci with Alzheimer's Disease in Han Chinese.Mol Neurobiol. 2017 Jan;54(1):308-318. doi: 10.1007/s12035-015-9649-5. Epub 2016 Jan 6.
1222 A disease-modifying treatment for Alzheimer's disease: focus on the trans-sulfuration pathway.Rev Neurosci. 2020 Apr 28;31(3):319-334. doi: 10.1515/revneuro-2019-0076.
1223 Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease.Gene. 2001 Jun 27;271(2):159-69. doi: 10.1016/s0378-1119(01)00521-2.
1224 A novel Alzheimer disease locus located near the gene encoding tau protein.Mol Psychiatry. 2016 Jan;21(1):108-17. doi: 10.1038/mp.2015.23. Epub 2015 Mar 17.
1225 A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease.Neurosci Lett. 2010 Jan 1;468(1):1-2. doi: 10.1016/j.neulet.2009.10.040. Epub 2009 Oct 22.
1226 ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells.Biochem Biophys Res Commun. 2007 Jan 5;352(1):111-7. doi: 10.1016/j.bbrc.2006.10.181. Epub 2006 Nov 9.
1227 Estrogen regulation of the neprilysin gene through a hormone-responsive element.J Mol Neurosci. 2009 Sep;39(1-2):22-6. doi: 10.1007/s12031-008-9168-1. Epub 2009 Jan 6.
1228 A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum.Mol Cell Neurosci. 2019 Oct;100:103401. doi: 10.1016/j.mcn.2019.103401. Epub 2019 Sep 3.
1229 Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin 1; ADAP1) in neuroblastoma cells.Neurochem Int. 2011 Nov;59(6):936-44. doi: 10.1016/j.neuint.2011.07.004. Epub 2011 Jul 23.
1230 Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease.Neurobiol Aging. 2014 Aug;35(8):1785-91. doi: 10.1016/j.neurobiolaging.2014.02.018. Epub 2014 Mar 1.
1231 Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.Ann Neurol. 2010 Aug;68(2):220-30. doi: 10.1002/ana.22052.
1232 acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.Cell Cycle. 2017 Oct 2;16(19):1800-1809. doi: 10.1080/15384101.2017.1344798. Epub 2017 Sep 21.
1233 The Adiponectin Homolog Osmotin Enhances Neurite Outgrowth and Synaptic Complexity via AdipoR1/NgR1 Signaling in Alzheimer's Disease.Mol Neurobiol. 2018 Aug;55(8):6673-6686. doi: 10.1007/s12035-017-0847-1. Epub 2018 Jan 15.
1234 Direct evidence for binding of aluminum to NAP anti-amyloid peptide and its analogs.Eur J Mass Spectrom (Chichester). 2020 Apr;26(2):106-116. doi: 10.1177/1469066719877714. Epub 2019 Sep 24.
1235 Promoter DNA hypermethylation - Implications for Alzheimer's disease.Neurosci Lett. 2019 Oct 15;711:134403. doi: 10.1016/j.neulet.2019.134403. Epub 2019 Jul 24.
1236 Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer's Disease.Front Neurol. 2018 Mar 19;9:145. doi: 10.3389/fneur.2018.00145. eCollection 2018.
1237 Associations of White Matter Hyperintensities with Cognitive Decline: A Longitudinal Study.J Alzheimers Dis. 2020;73(2):759-768. doi: 10.3233/JAD-191005.
1238 Amyloid beta induces cellular relocalization and production of agrin and glypican-1.Brain Res. 2009 Mar 13;1260:38-46. doi: 10.1016/j.brainres.2008.12.063. Epub 2009 Jan 7.
1239 Reduction of AHI1 in the serum of Taiwanese with probable Alzheimer's disease.Clin Biochem. 2020 Feb;76:24-30. doi: 10.1016/j.clinbiochem.2019.11.011. Epub 2019 Nov 28.
1240 Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer's disease.J Neuroinflammation. 2019 Nov 26;16(1):236. doi: 10.1186/s12974-019-1639-5.
1241 Suppression of AIMP1 protects cognition in Alzheimer's disease model mice 3xTg-AD.Neuroreport. 2017 Jan 18;28(2):82-86. doi: 10.1097/WNR.0000000000000710.
1242 Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPAR/ABCA1-dependent Cholesterol Efflux Mechanisms.Neurotherapeutics. 2019 Apr;16(2):505-522. doi: 10.1007/s13311-018-00704-1.
1243 Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.J Neuroimmune Pharmacol. 2018 Jun;13(2):254-264. doi: 10.1007/s11481-018-9781-x. Epub 2018 Mar 7.
1244 The efficacy and underlying mechanism of phosphodiesterase- 5 inhibitors in preventing cognitive impairment and Alzheimer pathology: A systematic review of animal studies.Behav Brain Res. 2019 Oct 17;372:112004. doi: 10.1016/j.bbr.2019.112004. Epub 2019 Jun 1.
1245 Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.Mol Ther Nucleic Acids. 2019 Dec 6;18:1049-1062. doi: 10.1016/j.omtn.2019.10.030. Epub 2019 Nov 6.
1246 Diverse mechanisms of autophagy dysregulation and their therapeutic implications: does the shoe fit?.Autophagy. 2019 Feb;15(2):368-371. doi: 10.1080/15548627.2018.1509609. Epub 2018 Sep 13.
1247 Cholesterol-related genes in Alzheimer's disease.Biochim Biophys Acta. 2010 Aug;1801(8):762-73. doi: 10.1016/j.bbalip.2010.05.009. Epub 2010 May 24.
1248 Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.J Neurosci. 2003 Jul 2;23(13):5887-96. doi: 10.1523/JNEUROSCI.23-13-05887.2003.
1249 Gene expression variance in hippocampal tissue of temporal lobe epilepsy patients corresponds to differential memory performance.Neurobiol Dis. 2016 Feb;86:121-30. doi: 10.1016/j.nbd.2015.11.011. Epub 2015 Nov 26.
1250 Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):727-31. doi: 10.1002/ajmg.b.30670.
1251 The association of DRD2 -141C and ANKK1 TaqIA polymorphisms with alcohol dependence in Korean population classified by the Lesch typology.Alcohol Alcohol. 2013 Jul-Aug;48(4):426-32. doi: 10.1093/alcalc/agt029. Epub 2013 Apr 4.
1252 Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.Alzheimers Dement. 2019 Oct;15(10):1333-1347. doi: 10.1016/j.jalz.2019.06.4950. Epub 2019 Aug 28.
1253 The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.J Alzheimers Dis. 2004 Feb;6(1):67-78. doi: 10.3233/jad-2004-6108.
1254 Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits.J Alzheimers Dis. 2018;63(4):1537-1546. doi: 10.3233/JAD-180090.
1255 The Molecular Misreading of APP and UBB Induces a Humoral Immune Response in Alzheimer's Disease Patients with Diagnostic Ability.Mol Neurobiol. 2020 Feb;57(2):1009-1020. doi: 10.1007/s12035-019-01809-0. Epub 2019 Oct 26.
1256 A genetic variant near adaptor-related protein complex 2 alpha 2 subunit gene is associated with coronary artery disease in a Chinese population.BMC Cardiovasc Disord. 2018 Aug 7;18(1):161. doi: 10.1186/s12872-018-0905-2.
1257 Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.J Alzheimers Dis. 2010;20(1):31-6. doi: 10.3233/JAD-2009-1341.
1258 Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease.J Neurosci. 2008 Dec 31;28(53):14392-400. doi: 10.1523/JNEUROSCI.2481-08.2008.
1259 GSK3 Interactions with Amyloid Genes: An Autopsy Verification and Extension.Neurotox Res. 2015 Oct;28(3):232-8. doi: 10.1007/s12640-015-9541-0. Epub 2015 Jul 21.
1260 Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein.Biochem Biophys Res Commun. 1999 May 10;258(2):385-9. doi: 10.1006/bbrc.1999.0639.
1261 In Vitro Assay Development and HTS of Small-Molecule Human ABAD/17-HSD10 Inhibitors as Therapeutics in Alzheimer's Disease.SLAS Discov. 2017 Jul;22(6):676-685. doi: 10.1177/2472555217697964. Epub 2017 Mar 17.
1262 APH-1A Component of -Secretase Forms an Internal Water and Ion-Containing Cavity.ACS Chem Neurosci. 2019 Jun 19;10(6):2931-2938. doi: 10.1021/acschemneuro.9b00150. Epub 2019 Apr 23.
1263 The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease.Acta Neuropathol Commun. 2019 Jan 31;7(1):13. doi: 10.1186/s40478-019-0660-3.
1264 HDX-MS reveals orthosteric and allosteric changes in apolipoprotein-D structural dynamics upon binding of progesterone.Protein Sci. 2019 Feb;28(2):365-374. doi: 10.1002/pro.3534. Epub 2018 Dec 20.
1265 Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population.Neurosci Lett. 2004 Jun 10;363(2):139-43. doi: 10.1016/j.neulet.2004.03.066.
1266 Evidence that the rab5 effector APPL1 mediates APP-CTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Mol Psychiatry. 2016 May;21(5):707-16. doi: 10.1038/mp.2015.97. Epub 2015 Jul 21.
1267 Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease.Cells. 2019 Jan 27;8(2):90. doi: 10.3390/cells8020090.
1268 A modulates actin cytoskeleton via SHIP2-mediated phosphoinositide metabolism.Sci Rep. 2019 Oct 29;9(1):15557. doi: 10.1038/s41598-019-51914-2.
1269 The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.Mol Neurobiol. 2018 Feb;55(2):1217-1226. doi: 10.1007/s12035-017-0397-6. Epub 2017 Jan 20.
1270 Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.J Clin Invest. 2017 May 1;127(5):1646-1650. doi: 10.1172/JCI85504. Epub 2017 Mar 27.
1271 The left frontal cortex supports reserve in aging by enhancing functional network efficiency.Alzheimers Res Ther. 2018 Mar 6;10(1):28. doi: 10.1186/s13195-018-0358-y.
1272 G proteins, p60TRP, and neurodegenerative diseases.Mol Neurobiol. 2013 Jun;47(3):1103-11. doi: 10.1007/s12035-013-8410-1. Epub 2013 Jan 24.
1273 Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit.Neurobiol Dis. 2014 Apr;64:16-29. doi: 10.1016/j.nbd.2013.12.003. Epub 2013 Dec 15.
1274 Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling.Biosci Rep. 2018 Jul 2;38(4):BSR20180127. doi: 10.1042/BSR20180127. Print 2018 Aug 31.
1275 P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis.J Cell Mol Med. 2011 Nov;15(11):2462-77. doi: 10.1111/j.1582-4934.2010.01248.x.
1276 Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.Neurobiol Aging. 2012 Aug;33(8):1843.e9-17. doi: 10.1016/j.neurobiolaging.2011.12.036. Epub 2012 Feb 1.
1277 Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.J Neural Transm Suppl. 2001;(61):263-72. doi: 10.1007/978-3-7091-6262-0_21.
1278 The Molecular Chaperone Artemin Efficiently Blocks Fibrillization of TAU Protein In Vitro.Cell J. 2018 Jan;19(4):569-577. doi: 10.22074/cellj.2018.4510. Epub 2017 Nov 4.
1279 Alzheimer Disease and Mild Cognitive Impairment: Integrated Pulsed Arterial Spin-Labeling MRI and (18)F-FDG PET.Radiology. 2018 Jul;288(1):198-206. doi: 10.1148/radiol.2018170575. Epub 2018 May 15.
1280 Targeting Neuroplasticity, Cardiovascular, and Cognitive-Associated Genomic Variants in Familial Alzheimer's Disease.Mol Neurobiol. 2019 May;56(5):3235-3243. doi: 10.1007/s12035-018-1298-z. Epub 2018 Aug 15.
1281 Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease.Neurobiol Aging. 2010 Mar;31(3):409-15. doi: 10.1016/j.neurobiolaging.2008.04.009. Epub 2008 May 22.
1282 Activating transcription factor 2 expression in the adult human brain: association with both neurodegeneration and neurogenesis.Neuroscience. 2005;133(2):437-51. doi: 10.1016/j.neuroscience.2005.02.029.
1283 Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: from structural insights to post-transcriptional regulatory roles.Mol Cell Neurosci. 2013 Sep;56:436-46. doi: 10.1016/j.mcn.2012.12.002. Epub 2012 Dec 14.
1284 Plasma ATG5 is increased in Alzheimer's disease.Sci Rep. 2019 Mar 18;9(1):4741. doi: 10.1038/s41598-019-41347-2.
1285 A genome-wide association study of aging.Neurobiol Aging. 2011 Nov;32(11):2109.e15-28. doi: 10.1016/j.neurobiolaging.2011.05.026. Epub 2011 Jul 22.
1286 Phospholipids and calmodulin modulate the inhibition of PMCA activity by tau.Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1028-1035. doi: 10.1016/j.bbamcr.2016.10.023. Epub 2016 Nov 3.
1287 Therapeutic Potential of Selectively Targeting the (2C)-Adrenoceptor in Cognition, Depression, and Schizophrenia-New Developments and Future Perspective.Front Psychiatry. 2017 Aug 14;8:144. doi: 10.3389/fpsyt.2017.00144. eCollection 2017.
1288 Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression inthe Cerebral Cortex of an Alzheimer's Disease Mouse Model.J Alzheimers Dis. 2017;56(1):47-61. doi: 10.3233/JAD-160677.
1289 Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.Hum Mol Genet. 2015 Nov 15;24(22):6492-504. doi: 10.1093/hmg/ddv358. Epub 2015 Sep 10.
1290 ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.Mol Psychiatry. 2014 Jun;19(6):682-7. doi: 10.1038/mp.2013.86. Epub 2013 Jul 16.
1291 Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51. doi: 10.1016/j.neurobiolaging.2004.10.003. Epub 2004 Dec 22.
1292 Human ApoE 2 Promotes Regulatory Mechanisms of Bioenergetic and Synaptic Function in Female Brain: A Focus on V-type H+-ATPase.J Alzheimers Dis. 2016 Jun 18;53(3):1015-31. doi: 10.3233/JAD-160307.
1293 Genome-wide association study identified ATP6V1H locus influencing cerebrospinal fluid BACE activity.BMC Med Genet. 2018 May 11;19(1):75. doi: 10.1186/s12881-018-0603-z.
1294 Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.Ann Hum Genet. 2012 Sep;76(5):342-51. doi: 10.1111/j.1469-1809.2012.00721.x.
1295 Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.PLoS Med. 2017 Mar 21;14(3):e1002258. doi: 10.1371/journal.pmed.1002258. eCollection 2017 Mar.
1296 The Healthy Brain Project: An Online Platform for the Recruitment, Assessment, and Monitoring of Middle-Aged Adults at Risk of Developing Alzheimer's Disease.J Alzheimers Dis. 2019;68(3):1211-1228. doi: 10.3233/JAD-181139.
1297 DNA Hypomethylation in Blood Links B3GALT4 and ZADH2 to Alzheimer's Disease.J Alzheimers Dis. 2018;66(3):927-934. doi: 10.3233/JAD-180592.
1298 HNK-1 Carrier Glycoproteins Are Decreased in the Alzheimer's Disease Brain.Mol Neurobiol. 2017 Jan;54(1):188-199. doi: 10.1007/s12035-015-9644-x. Epub 2016 Jan 6.
1299 Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadic Dementia in Rats.Front Neurosci. 2018 Sep 21;12:653. doi: 10.3389/fnins.2018.00653. eCollection 2018.
1300 Effects of BIS-MEP on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of -Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease.Front Aging Neurosci. 2019 Jan 22;11:3. doi: 10.3389/fnagi.2019.00003. eCollection 2019.
1301 Bag5 protects neuronal cells from amyloid -induced cell death.J Mol Neurosci. 2015 Apr;55(4):815-20. doi: 10.1007/s12031-014-0433-1. Epub 2014 Nov 1.
1302 Functional enrichment analysis of three Alzheimer's disease genome-wide association studies identities DAB1 as a novel candidate liability/protective gene.Biochem Biophys Res Commun. 2015 Aug 7;463(4):490-5. doi: 10.1016/j.bbrc.2015.05.044. Epub 2015 May 29.
1303 Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice.Acta Neuropathol Commun. 2015 Sep 4;3:54. doi: 10.1186/s40478-015-0233-z.
1304 BAP31 deficiency contributes to the formation of amyloid- plaques in Alzheimer's disease by reducing the stability of RTN3.FASEB J. 2019 Apr;33(4):4936-4946. doi: 10.1096/fj.201801702R. Epub 2018 Dec 31.
1305 Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer's Disease and Neuronal Cell Death.ACS Chem Neurosci. 2019 Aug 21;10(8):3555-3564. doi: 10.1021/acschemneuro.9b00177. Epub 2019 Jun 12.
1306 Intranasal administration of TAT-haFGF() attenuates disease progression in a mouse model of Alzheimer's disease.Neuroscience. 2012 Oct 25;223:225-37. doi: 10.1016/j.neuroscience.2012.08.003. Epub 2012 Aug 9.
1307 Anti-inflammatory potential of thymosin 4 in the central nervous system: implications for progressive neurodegenerative diseases.Expert Opin Biol Ther. 2018 Jul;18(sup1):165-169. doi: 10.1080/14712598.2018.1486817.
1308 Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study.Lancet Neurol. 2016 Jul;15(8):811-819. doi: 10.1016/S1474-4422(16)30030-8. Epub 2016 May 11.
1309 Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.Sci Rep. 2017 Dec 19;7(1):17762. doi: 10.1038/s41598-017-17999-3.
1310 FE65 regulates and interacts with the Bloom syndrome protein in dynamic nuclear spheres - potential relevance to Alzheimer's disease.J Cell Sci. 2013 Jun 1;126(Pt 11):2480-92. doi: 10.1242/jcs.121004. Epub 2013 Apr 9.
1311 Vincamine Alleviates Amyloid- 25-35 Peptides-induced Cytotoxicity in PC12 Cells.Pharmacogn Mag. 2017 Jan-Mar;13(49):123-128. doi: 10.4103/0973-1296.196309.
1312 ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology.Acta Neuropathol. 2014;127(6):825-43. doi: 10.1007/s00401-014-1282-2. Epub 2014 Apr 27.
1313 Long-Term Extensions of Randomized Vaccination Trials of ACC-001 and QS-21 in Mild to Moderate Alzheimer's Disease.Curr Alzheimer Res. 2017;14(7):696-708. doi: 10.2174/1567205014666170117101537.
1314 Dysregulation of Autophagy, Mitophagy, and Apoptosis Genes in the CA3 Region of the Hippocampus in the Ischemic Model of Alzheimer's Disease in the Rat.J Alzheimers Dis. 2019;72(4):1279-1286. doi: 10.3233/JAD-190966.
1315 BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.J Biol Chem. 2009 Jun 5;284(23):15815-25. doi: 10.1074/jbc.M109.006403. Epub 2009 Apr 14.
1316 Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.J Alzheimers Dis. 2016 Feb 26;52(1):43-50. doi: 10.3233/JAD-151073.
1317 BAG-1M co-activates BACE1 transcription through NF-B and accelerates A production and memory deficit in Alzheimer's disease mouse model.Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2398-2407. doi: 10.1016/j.bbadis.2017.05.014. Epub 2017 May 11.
1318 Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain.J Neuroinflammation. 2017 Mar 6;14(1):48. doi: 10.1186/s12974-017-0814-9.
1319 Central CRF system perturbation in an Alzheimer's disease knockin mouse model.Neurobiol Aging. 2012 Nov;33(11):2678-91. doi: 10.1016/j.neurobiolaging.2012.01.002. Epub 2012 Feb 14.
1320 Quantitative proteomics reveals distinct composition of amyloid plaques in Alzheimer's disease.Alzheimers Dement. 2019 Mar;15(3):429-440. doi: 10.1016/j.jalz.2018.10.006. Epub 2019 Jan 2.
1321 The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.Neurochem Res. 1999 Jun;24(6):767-74. doi: 10.1023/a:1020783614031.
1322 A human-specific de novo protein-coding gene associated with human brain functions.PLoS Comput Biol. 2010 Mar 26;6(3):e1000734. doi: 10.1371/journal.pcbi.1000734.
1323 Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease.J Neurosci. 2000 Oct 15;20(20):7505-9. doi: 10.1523/JNEUROSCI.20-20-07505.2000.
1324 Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients.J Mol Neurosci. 2012 Jun;47(2):207-18. doi: 10.1007/s12031-012-9717-5. Epub 2012 Mar 14.
1325 Amyloid pathology-produced unexpected modifications of calcium homeostasis in hippocampal subicular dendrites.Alzheimers Dement. 2020 Feb;16(2):251-261. doi: 10.1016/j.jalz.2019.07.017. Epub 2020 Jan 6.
1326 Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.Nat Commun. 2014 Mar 25;5:3496. doi: 10.1038/ncomms4496.
1327 AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease.Adv Exp Med Biol. 2019;1111:55-76. doi: 10.1007/5584_2018_218.
1328 Calmodulin-like skin protein suppresses the increase in senescence-associated -galactosidase induced by hydrogen peroxide or ultraviolet irradiation in keratinocytes.Cell Biol Int. 2019 Jul;43(7):835-843. doi: 10.1002/cbin.11159. Epub 2019 May 18.
1329 Alterations of Ca?responsive proteins within cholinergic neurons in aging and Alzheimer's disease.Neurobiol Aging. 2014 Jun;35(6):1325-33. doi: 10.1016/j.neurobiolaging.2013.12.017. Epub 2013 Dec 25.
1330 A Comprehensive Analysis of the CaMK2A Gene and Susceptibility to Alzheimer's Disease in the Han Chinese Population.Front Aging Neurosci. 2019 Apr 11;11:84. doi: 10.3389/fnagi.2019.00084. eCollection 2019.
1331 Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats.Neural Regen Res. 2017 Sep;12(9):1479-1484. doi: 10.4103/1673-5374.215260.
1332 Modulating Conformation of A-Peptide: An Effective Way to Prevent Protein-Misfolding Disease.Inorg Chem. 2018 Nov 5;57(21):13533-13543. doi: 10.1021/acs.inorgchem.8b02115. Epub 2018 Oct 22.
1333 Adenovirus E1A inhibits IFN-induced resistance to cytolysis by natural killer cells.J Immunol. 1993 May 15;150(10):4315-22.
1334 Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women.Dement Geriatr Cogn Disord. 2008;26(3):247-50. doi: 10.1159/000160956. Epub 2008 Oct 8.
1335 Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology.Cell Signal. 2018 Jan;42:211-226. doi: 10.1016/j.cellsig.2017.10.018. Epub 2017 Nov 7.
1336 Calpastatin Mediates Development of Alzheimer's Disease in Diabetes.J Alzheimers Dis. 2019;68(3):1051-1059. doi: 10.3233/JAD-190004.
1337 Blood transcriptomic biomarkers of Alzheimer's disease patients treated with EHT 0202.J Alzheimers Dis. 2013;34(2):469-83. doi: 10.3233/JAD-121501.
1338 Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease.Acta Pharmacol Sin. 2018 Sep;39(9):1421-1438. doi: 10.1038/aps.2017.210. Epub 2018 May 17.
1339 Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid- toxicity.Neurobiol Aging. 2015 Feb;36(2):1057-71. doi: 10.1016/j.neurobiolaging.2014.11.006. Epub 2014 Nov 15.
1340 Haptoglobin phenotypes in dementia of the Alzheimer type.Hum Hered. 1986;36(2):93-6. doi: 10.1159/000153606.
1341 Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.Neurology. 2011 Jan 4;76(1):69-79. doi: 10.1212/WNL.0b013e318204a397. Epub 2010 Dec 1.
1342 Genome-wide association study of Alzheimer's disease.Transl Psychiatry. 2012 May 15;2(5):e117. doi: 10.1038/tp.2012.45.
1343 Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies.Lancet Neurol. 2020 Jan;19(1):61-70. doi: 10.1016/S1474-4422(19)30393-X. Epub 2019 Nov 6.
1344 Altered levels of blood proteins in Alzheimer's disease longitudinal study: Results from Australian Imaging Biomarkers Lifestyle Study of Ageing cohort.Alzheimers Dement (Amst). 2017 Apr 23;8:60-72. doi: 10.1016/j.dadm.2017.04.003. eCollection 2017.
1345 Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis.Cytokine. 2010 May;50(2):181-5. doi: 10.1016/j.cyto.2010.02.016. Epub 2010 Mar 16.
1346 Peripheral Blood Mononuclear Cells of Alzheimer's Disease Patients Control CCL4 and CXCL10 Levels in a Human Blood Brain Barrier Model.Curr Alzheimer Res. 2017;14(11):1215-1228. doi: 10.2174/1567205014666170417110337.
1347 Polymorphonuclear Neutrophil Functions are Differentially Altered in Amnestic Mild Cognitive Impairment and Mild Alzheimer's Disease Patients.J Alzheimers Dis. 2017;60(1):23-42. doi: 10.3233/JAD-170124.
1348 CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration.J Neurol. 2009 Aug;256(8):1379-81. doi: 10.1007/s00415-009-5138-y. Epub 2009 May 5.
1349 Cyclin C expression is involved in the pathogenesis of Alzheimer's disease.Neurobiol Aging. 2003 May-Jun;24(3):427-35. doi: 10.1016/s0197-4580(02)00132-x.
1350 Hippocampal expression of cell-adhesion glycoprotein neuroplastin is altered in Alzheimer's disease.J Cell Mol Med. 2019 Feb;23(2):1602-1607. doi: 10.1111/jcmm.13998. Epub 2018 Nov 28.
1351 Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals.Eur J Epidemiol. 2019 Jun;34(6):579-590. doi: 10.1007/s10654-019-00498-2. Epub 2019 Mar 4.
1352 Estrogen receptor variants modify risk for Alzheimer's disease in a multiethnic female cohort.J Alzheimers Dis. 2014;40(1):83-93. doi: 10.3233/JAD-130551.
1353 Subtyping of circulating exosome-bound amyloid reflects brain plaque deposition.Nat Commun. 2019 Mar 8;10(1):1144. doi: 10.1038/s41467-019-09030-2.
1354 High complement levels in astrocyte-derived exosomes of Alzheimer disease.Ann Neurol. 2018 Mar;83(3):544-552. doi: 10.1002/ana.25172. Epub 2018 Mar 10.
1355 Alzheimer's disease and HLA-A2: linking neurodegenerative to immune processes through an in silico approach.Biomed Res Int. 2014;2014:791238. doi: 10.1155/2014/791238. Epub 2014 Aug 17.
1356 Regulatory mechanism of microRNA-377 on CDH13 expression in the cell model of Alzheimer's disease.Eur Rev Med Pharmacol Sci. 2018 May;22(9):2801-2808. doi: 10.26355/eurrev_201805_14979.
1357 CDK5RAP2 gene and tau pathophysiology in late-onset sporadic Alzheimer's disease.Alzheimers Dement. 2018 Jun;14(6):787-796. doi: 10.1016/j.jalz.2017.12.004. Epub 2018 Jan 19.
1358 Characterization of CDNF-Secreting ARPE-19 Cell Clones for Encapsulated Cell Therapy.Cell Transplant. 2019 Apr;28(4):413-424. doi: 10.1177/0963689719827943. Epub 2019 Mar 6.
1359 Gullibility may be a warning sign of Alzheimer's disease dementia.Int Psychogeriatr. 2019 Mar;31(3):363-370. doi: 10.1017/S1041610218000844. Epub 2018 Jun 25.
1360 Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan.Lett Appl Microbiol. 2018 Jun;66(6):464-471. doi: 10.1111/lam.12882. Epub 2018 Apr 16.
1361 Astrocytic CCAAT/Enhancer-binding protein delta contributes to reactive oxygen species formation in neuroinflammation.Redox Biol. 2018 Jun;16:104-112. doi: 10.1016/j.redox.2018.02.011. Epub 2018 Feb 16.
1362 Regional Cerebral Blood Flow in the Posterior Cingulate and Precuneus and the Entorhinal Cortical Atrophy Score Differentiate Mild Cognitive Impairment and Dementia Due to Alzheimer Disease.AJNR Am J Neuroradiol. 2019 Oct;40(10):1658-1664. doi: 10.3174/ajnr.A6219. Epub 2019 Sep 12.
1363 Genetic association of CUGBP2 and DNMBP with Alzheimer' s disease in the Chinese Han population.Curr Alzheimer Res. 2015;12(3):228-32. doi: 10.2174/156720501203150317151426.
1364 Sex-dependent co-occurrence of hypoxia and -amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3Tg-AD mouse model of Alzheimer's disease.Mol Cell Neurosci. 2018 Oct;92:67-81. doi: 10.1016/j.mcn.2018.06.005. Epub 2018 Jun 25.
1365 Goodpasture antigen-binding protein/ceramide transporter binds to human serum amyloid P-component and is present in brain amyloid plaques.J Biol Chem. 2012 Apr 27;287(18):14897-911. doi: 10.1074/jbc.M111.299545. Epub 2012 Mar 6.
1366 Curcuminoid submicron particle ameliorates cognitive deficits and decreases amyloid pathology in Alzheimer's disease mouse model.Oncotarget. 2018 Jan 31;9(12):10681-10697. doi: 10.18632/oncotarget.24369. eCollection 2018 Feb 13.
1367 Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain.J Neural Transm Suppl. 2003;(67):117-28. doi: 10.1007/978-3-7091-6721-2_10.
1368 Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.Front Aging Neurosci. 2018 Feb 6;10:27. doi: 10.3389/fnagi.2018.00027. eCollection 2018.
1369 Identifying unexpected therapeutic targets via chemical-protein interactome.PLoS One. 2010 Mar 8;5(3):e9568. doi: 10.1371/journal.pone.0009568.
1370 Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease.Brain Res. 1999 Oct 16;845(1):1-5. doi: 10.1016/s0006-8993(99)01767-9.
1371 Microglial motility in Alzheimer's disease and after A42 immunotherapy: a human post-mortem study.Acta Neuropathol Commun. 2019 Nov 8;7(1):174. doi: 10.1186/s40478-019-0828-x.
1372 Mitochondrial CHCHD2 and CHCHD10: Roles in Neurological Diseases and Therapeutic Implications.Neuroscientist. 2020 Apr;26(2):170-184. doi: 10.1177/1073858419871214. Epub 2019 Sep 16.
1373 A Parallel Reaction Monitoring Mass Spectrometric Method for Analysis of Potential CSF Biomarkers for Alzheimer's Disease.Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700131. Epub 2017 Nov 23.
1374 Different chromogranin immunoreactivity between prion and a-beta amyloid plaque.Neuroreport. 2003 Apr 15;14(5):755-8. doi: 10.1097/00001756-200304150-00019.
1375 Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels.Alzheimers Res Ther. 2018 Aug 28;10(1):86. doi: 10.1186/s13195-018-0410-y.
1376 Effect of tau-pathology on charged multivesicular body protein 2b (CHMP2B).Brain Res. 2019 Mar 1;1706:224-236. doi: 10.1016/j.brainres.2018.11.008. Epub 2018 Nov 8.
1377 Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease.J Alzheimers Dis. 2002 Apr;4(2):71-6. doi: 10.3233/jad-2002-4201.
1378 The Emerging Roles of CIB1 in Cancer.Cell Physiol Biochem. 2017;43(4):1413-1424. doi: 10.1159/000481873. Epub 2017 Oct 11.
1379 Neuropathology-driven Whole-genome Sequencing Study Points to Novel Candidate Genes for Healthy Brain Aging.Alzheimer Dis Assoc Disord. 2019 Jan-Mar;33(1):7-14. doi: 10.1097/WAD.0000000000000294.
1380 CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.Neurobiol Aging. 2019 Mar;75:198-208. doi: 10.1016/j.neurobiolaging.2018.11.023. Epub 2018 Dec 6.
1381 Upregulation of Cisd2 attenuates Alzheimer's-related neuronal loss in mice.J Pathol. 2020 Mar;250(3):299-311. doi: 10.1002/path.5374. Epub 2020 Jan 13.
1382 Open-closed motion of Mint2 regulates APP metabolism.J Mol Cell Biol. 2013 Feb;5(1):48-56. doi: 10.1093/jmcb/mjs033. Epub 2012 Jun 21.
1383 Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia.Neuroscience. 2015 Aug 27;302:121-37. doi: 10.1016/j.neuroscience.2014.09.052. Epub 2014 Oct 5.
1384 Differences in structure and function between human and murine tau.Biochim Biophys Acta Mol Basis Dis. 2019 Aug 1;1865(8):2024-2030. doi: 10.1016/j.bbadis.2018.08.010. Epub 2018 Aug 12.
1385 A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid- Protein by Modulating APP Processing and Autophagy.J Alzheimers Dis. 2019;72(3):761-771. doi: 10.3233/JAD-190562.
1386 Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis.Am J Pathol. 2015 Oct;185(10):2777-89. doi: 10.1016/j.ajpath.2015.06.021. Epub 2015 Aug 28.
1387 Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.JAMA Neurol. 2015 Nov;72(11):1313-23. doi: 10.1001/jamaneurol.2015.1700.
1388 The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment.J Cell Mol Med. 2019 May;23(5):3280-3292. doi: 10.1111/jcmm.14214. Epub 2019 Feb 22.
1389 C-type lectin-like receptor 2 and zonulin are associated with mild cognitive impairment and Alzheimer's disease.Acta Neurol Scand. 2020 Mar;141(3):250-255. doi: 10.1111/ane.13196. Epub 2019 Nov 25.
1390 Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer's disease.Aging Cell. 2020 Feb;19(2):e13078. doi: 10.1111/acel.13078. Epub 2019 Dec 4.
1391 Decrease in p3-Alc37 and p3-Alc40, products of Alcadein generated by -secretase cleavages, in aged monkeys and patients with Alzheimer's disease.Alzheimers Dement (N Y). 2019 Nov 7;5:740-750. doi: 10.1016/j.trci.2019.09.015. eCollection 2019.
1392 Genetics of clusterin isoform expression and Alzheimer's disease risk.PLoS One. 2012;7(4):e33923. doi: 10.1371/journal.pone.0033923. Epub 2012 Apr 10.
1393 Alzheimer's Disease Assessment Scale-Cognitive subscale variants in mild cognitive impairment and mild Alzheimer's disease: change over time and the effect of enrichment strategies.Alzheimers Res Ther. 2016 Feb 12;8:8. doi: 10.1186/s13195-016-0170-5.
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1395 BP180 Autoantibodies Target Different Epitopes in Multiple Sclerosis or Alzheimer's Disease than in Bullous Pemphigoid.J Invest Dermatol. 2019 Feb;139(2):293-299. doi: 10.1016/j.jid.2018.09.010. Epub 2018 Oct 10.
1396 Hemizygous deletion of COL3A1, COL5A2, and MSTN causes a complex phenotype with aortic dissection: a lesson for and from true haploinsufficiency.Eur J Hum Genet. 2010 Dec;18(12):1315-21. doi: 10.1038/ejhg.2010.105. Epub 2010 Jul 21.
1397 Lack of association of mortalin (HSPA9) and other mitochondria-related genes with risk of Parkinson's and Alzheimer's diseases.Neurobiol Aging. 2017 Jan;49:215.e9-215.e10. doi: 10.1016/j.neurobiolaging.2016.09.017. Epub 2016 Oct 3.
1398 Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.Mol Neurodegener. 2018 Jun 28;13(1):34. doi: 10.1186/s13024-018-0266-4.
1399 Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese.Neuropsychopharmacology. 2018 Oct;43(11):2264-2276. doi: 10.1038/s41386-018-0144-3. Epub 2018 Jul 6.
1400 Analysis of the genes coding for subunit 10 and 15 of cytochrome c oxidase in Alzheimer's disease.J Neural Transm (Vienna). 2009 Dec;116(12):1635-41. doi: 10.1007/s00702-009-0324-8. Epub 2009 Oct 14.
1401 Copper in Glucose Intolerance, Cognitive Decline, and Alzheimer Disease.Alzheimer Dis Assoc Disord. 2019 Jan-Mar;33(1):77-85. doi: 10.1097/WAD.0000000000000280.
1402 The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease.Mol Cell Proteomics. 2020 Jan;19(1):128-141. doi: 10.1074/mcp.RA119.001737. Epub 2019 Nov 7.
1403 Targeting Apolipoprotein E/Amyloid Binding by Peptoid CPO_A17-21P Ameliorates Alzheimer's Disease Related Pathology and Cognitive Decline.Sci Rep. 2017 Aug 14;7(1):8009. doi: 10.1038/s41598-017-08604-8.
1404 PPAR/-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1E9 astrocytes.Glia. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19.
1405 Concurrent Alzheimer's pathology in patients with clinical normal pressure hydrocephalus.J Neurosurg Sci. 2020 Apr;64(2):130-132. doi: 10.23736/S0390-5616.18.04350-3. Epub 2018 Feb 13.
1406 PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.J Biol Chem. 2005 Apr 8;280(14):13824-32. doi: 10.1074/jbc.M411933200. Epub 2005 Jan 25.
1407 Reproducible evaluation of classification methods in Alzheimer's disease: Framework and application to MRI and PET data.Neuroimage. 2018 Dec;183:504-521. doi: 10.1016/j.neuroimage.2018.08.042. Epub 2018 Aug 18.
1408 Evolutionary origin of a Kunitz-type trypsin inhibitor domain inserted in the amyloid beta precursor protein of Alzheimer's disease.J Mol Evol. 1992 Jun;34(6):536-43. doi: 10.1007/BF00160466.
1409 Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old.Oncotarget. 2017 Mar 28;8(13):20612-20621. doi: 10.18632/oncotarget.15296.
1410 Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.Mol Psychiatry. 2020 Nov;25(11):2942-2951. doi: 10.1038/s41380-018-0298-8. Epub 2018 Dec 4.
1411 The potential inhibitory effect of -casein on the aggregation and deposition of A(1-42) fibrils in Alzheimer's disease: insight from in-vitro and in-silico studies.J Biomol Struct Dyn. 2018 Jun;36(8):2118-2130. doi: 10.1080/07391102.2017.1345326. Epub 2017 Jul 4.
1412 Cystatin F is a biomarker of prion pathogenesis in mice.PLoS One. 2017 Feb 8;12(2):e0171923. doi: 10.1371/journal.pone.0171923. eCollection 2017.
1413 Structural elucidation and bioactivities of a novel arabinogalactan from Coreopsis tinctoria.Carbohydr Polym. 2019 Sep 1;219:219-228. doi: 10.1016/j.carbpol.2019.05.019. Epub 2019 May 7.
1414 Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping.BMC Med Genomics. 2019 Sep 9;12(1):128. doi: 10.1186/s12920-019-0574-8.
1415 The sterol carrier protein SCP-x/pro-SCP-2 gene has transcriptional activity and regulates the Alzheimer disease gamma-secretase.J Biol Chem. 2007 Jul 6;282(27):19742-52. doi: 10.1074/jbc.M611426200. Epub 2007 May 7.
1416 Polymorphisms of CHAT but not TFAM or VR22 are Associated with Alzheimer Disease Risk.Med Sci Monit. 2016 Jun 7;22:1924-35. doi: 10.12659/msm.895984.
1417 Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.J Food Drug Anal. 2019 Apr;27(2):551-564. doi: 10.1016/j.jfda.2018.11.009. Epub 2019 Jan 12.
1418 -Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.PLoS One. 2012;7(9):e43728. doi: 10.1371/journal.pone.0043728. Epub 2012 Sep 11.
1419 Analytical and clinical performances of the automated Lumipulse cerebrospinal fluid A(42) and T-Tau assays for Alzheimer's disease diagnosis.J Neurol. 2019 Sep;266(9):2304-2311. doi: 10.1007/s00415-019-09418-6. Epub 2019 Jun 10.
1420 Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APP(SWE)/PS1(E9) Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease.Front Cell Neurosci. 2018 Nov 6;12:397. doi: 10.3389/fncel.2018.00397. eCollection 2018.
1421 Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus--linking NMDA receptors and the reelin pathway.Exp Neurol. 2014 Nov;261:698-709. doi: 10.1016/j.expneurol.2014.07.023. Epub 2014 Aug 13.
1422 KIBRA and APOE Gene Variants Affect Brain Functional Network Connectivity in Healthy Older People.J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1725-1733. doi: 10.1093/gerona/glz004.
1423 A MicroRNA Derived from Adenovirus Virus-Associated RNAII Promotes Virus Infection via Posttranscriptional Gene Silencing.J Virol. 2019 Jan 4;93(2):e01265-18. doi: 10.1128/JVI.01265-18. Print 2019 Jan 15.
1424 Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease.Pharmacogenet Genomics. 2011 Apr;21(4):225-30. doi: 10.1097/FPC.0b013e32833f984c.
1425 Dominant and Protective Role of the CYTH4 Primate-Specific GTTT-Repeat Longer Alleles Against Neurodegeneration.J Mol Neurosci. 2015 Jul;56(3):593-6. doi: 10.1007/s12031-015-0542-5. Epub 2015 Apr 1.
1426 The -amyloid peptide compromises Reelin signaling in Alzheimer's disease.Sci Rep. 2016 Aug 17;6:31646. doi: 10.1038/srep31646.
1427 MicroRNA-26a/Death-Associated Protein Kinase1 Signaling Induces Synucleinopathy andDopaminergic Neuron Degeneration in Parkinson's Disease.Biol Psychiatry. 2019 May 1;85(9):769-781. doi: 10.1016/j.biopsych.2018.12.008. Epub 2018 Dec 19.
1428 Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer's disease.J Alzheimers Dis. 2015;43(4):1137-48. doi: 10.3233/JAD-141875.
1429 RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism.Neurosci Lett. 2013 Mar 1;536:90-5. doi: 10.1016/j.neulet.2012.12.042. Epub 2013 Jan 7.
1430 ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.Nat Commun. 2019 Jan 30;10(1):486. doi: 10.1038/s41467-019-08420-w.
1431 Human neural stem cells improve cognition and promote synaptic growth in two complementary transgenic models of Alzheimer's disease and neuronal loss.Hippocampus. 2015 Jul;25(7):813-26. doi: 10.1002/hipo.22405. Epub 2015 Jan 8.
1432 Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.J Neuroimmunol. 2018 Jun 15;319:80-92. doi: 10.1016/j.jneuroim.2018.03.009. Epub 2018 Mar 17.
1433 Identification of prefrontal cortex protein alterations in Alzheimer's disease.Oncotarget. 2018 Jan 24;9(13):10847-10867. doi: 10.18632/oncotarget.24303. eCollection 2018 Feb 16.
1434 Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.Free Radic Res. 2012 Apr;46(4):565-76. doi: 10.3109/10715762.2011.648188. Epub 2012 Jan 23.
1435 Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid- Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.Pharm Res. 2018 Feb 6;35(3):49. doi: 10.1007/s11095-017-2312-2.
1436 Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease.J Alzheimers Dis. 2018;64(3):995-1007. doi: 10.3233/JAD-180088.
1437 A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.J Clin Endocrinol Metab. 2018 May 1;103(5):1818-1826. doi: 10.1210/jc.2017-01196.
1438 Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer's disease as a mitophagy receptor.Aging Cell. 2019 Feb;18(1):e12860. doi: 10.1111/acel.12860. Epub 2018 Nov 28.
1439 5-Methoxyindole-2-carboxylic acid (MICA) suppresses A-mediated pathology in C. elegans.Exp Gerontol. 2018 Jul 15;108:215-225. doi: 10.1016/j.exger.2018.04.021. Epub 2018 Apr 27.
1440 Phenotypic down-regulation of glutamate receptor subunit GluR1 in Alzheimer's disease.Neurobiol Aging. 1999 May-Jun;20(3):287-95. doi: 10.1016/s0197-4580(99)00035-4.
1441 Crocin-protected malathion-induced spatial memory deficits by inhibiting TAU protein hyperphosphorylation and antiapoptotic effects.Nutr Neurosci. 2020 Mar;23(3):221-236. doi: 10.1080/1028415X.2018.1492772. Epub 2019 Feb 21.
1442 Dynamic SAP102 expression in the hippocampal subregions of rats and APP/PS1 mice of various ages.J Anat. 2018 Jun;232(6):987-996. doi: 10.1111/joa.12807. Epub 2018 Mar 25.
1443 Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.Antioxid Redox Signal. 2018 May 10;28(14):1323-1337. doi: 10.1089/ars.2016.6883. Epub 2017 Oct 17.
1444 Detection of A oligomers based on magnetic-field-assisted separation of aptamer-functionalized Fe(3)O(4) magnetic nanoparticles and BaYF(5):Yb,Er nanoparticles as upconversion fluorescence labels.Talanta. 2017 Aug 1;170:350-357. doi: 10.1016/j.talanta.2017.04.021. Epub 2017 Apr 14.
1445 Beta-Amyloid Increases the Expression Levels of Tid1 Responsible for Neuronal Cell Death and Amyloid Beta Production.Mol Neurobiol. 2020 Feb;57(2):1099-1114. doi: 10.1007/s12035-019-01807-2. Epub 2019 Nov 4.
1446 Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity.Am J Med Genet B Neuropsychiatr Genet. 2014 Jun;165B(4):283-93. doi: 10.1002/ajmg.b.32234. Epub 2014 May 1.
1447 Increased Expression of the Large Conductance, Calcium-Activated K+ (BK) Channel in Adult-Onset Neuronal Ceroid Lipofuscinosis.PLoS One. 2015 Apr 23;10(4):e0125205. doi: 10.1371/journal.pone.0125205. eCollection 2015.
1448 Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K).Neurosci Lett. 1999 Jul 9;269(2):115-9. doi: 10.1016/s0304-3940(99)00426-7.
1449 Dedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.J Cell Physiol. 2017 Aug;232(8):1931-1940. doi: 10.1002/jcp.25512. Epub 2017 Feb 28.
1450 Quantitative profiling of cytokines and chemokines in DOCK8-deficient and atopic dermatitis patients.Allergy. 2019 Feb;74(2):370-379. doi: 10.1111/all.13610. Epub 2018 Oct 15.
1451 S100a9 knockdown decreases the memory impairment and the neuropathology in Tg2576 mice, AD animal model.PLoS One. 2010 Jan 21;5(1):e8840. doi: 10.1371/journal.pone.0008840.
1452 Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.J Neurochem. 2007 Nov;103(3):1132-44. doi: 10.1111/j.1471-4159.2007.04829.x. Epub 2007 Aug 7.
1453 SNP Variation in MicroRNA Biogenesis Pathway Genes as a New Innovation Strategy for Alzheimer Disease Diagnostics: A Study of 10 Candidate Genes in an Understudied Population From the Eastern Mediterranean.Alzheimer Dis Assoc Disord. 2016 Jul-Sep;30(3):203-9. doi: 10.1097/WAD.0000000000000135.
1454 Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease.Neurosci Lett. 2006 Nov 20;408(3):203-8. doi: 10.1016/j.neulet.2006.09.005. Epub 2006 Oct 2.
1455 Increased cortical capillary transit time heterogeneity in Alzheimer's disease: a DSC-MRI perfusion study.Neurobiol Aging. 2017 Feb;50:107-118. doi: 10.1016/j.neurobiolaging.2016.11.004. Epub 2016 Nov 19.
1456 Insights from modeling the tertiary structure of human BACE2.J Proteome Res. 2004 Sep-Oct;3(5):1069-72. doi: 10.1021/pr049905s.
1457 Risk of Dementia in Older Patients with Type 2 Diabetes on Dipeptidyl-Peptidase IV Inhibitors Versus Sulfonylureas: A Real-World Population-Based Cohort Study.J Clin Med. 2018 Dec 28;8(1):28. doi: 10.3390/jcm8010028.
1458 Dystonin/BPAG1 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.Neurol Sci. 2019 Aug;40(8):1577-1582. doi: 10.1007/s10072-019-03879-3. Epub 2019 Apr 8.
1459 Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.Hippocampus. 2014 Apr;24(4):363-8. doi: 10.1002/hipo.22245. Epub 2014 Jan 28.
1460 Identification of genomic organisation, sequence variants and analysis of the role of the human dishevelled 1 gene in late onset Alzheimer's disease.Mol Psychiatry. 2002;7(1):104-9. doi: 10.1038/sj.mp.4000941.
1461 Diagnosis and prognosis of Alzheimer's disease using brain morphometry and white matter connectomes.Neuroimage Clin. 2019;23:101859. doi: 10.1016/j.nicl.2019.101859. Epub 2019 May 13.
1462 Long Noncoding RNA EBF3-AS Promotes Neuron Apoptosis in Alzheimer's Disease.DNA Cell Biol. 2018 Mar;37(3):220-226. doi: 10.1089/dna.2017.4012. Epub 2018 Jan 3.
1463 Cerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer's Disease: A Multiparametric Neuroimaging Study.Sci Rep. 2018 Jan 24;8(1):1541. doi: 10.1038/s41598-018-19387-x.
1464 Association analysis of polymorphisms in STARD6 and near ECHDC3 in Alzheimer's disease patients carrying the APOE 4 Allele.Neuropsychiatr Dis Treat. 2019 Jan 11;15:213-218. doi: 10.2147/NDT.S186705. eCollection 2019.
1465 Chronic Verubecestat Treatment Suppresses Amyloid Accumulation in Advanced Aged Tg2576-APPswe Mice Without Inducing Microhemorrhage.J Alzheimers Dis. 2017;59(4):1393-1413. doi: 10.3233/JAD-170056.
1466 Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.Genome Res. 2011 Mar;21(3):364-76. doi: 10.1101/gr.114280.110. Epub 2010 Dec 16.
1467 Genetic Risk as a Marker of Amyloid- and Tau Burden in Cerebrospinal Fluid.J Alzheimers Dis. 2017;55(4):1417-1427. doi: 10.3233/JAD-160707.
1468 Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis.Am J Med Genet B Neuropsychiatr Genet. 2009 Jan 5;150B(1):50-5. doi: 10.1002/ajmg.b.30767.
1469 Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease.J Alzheimers Dis. 2016 Sep 6;54(2):669-78. doi: 10.3233/JAD-160036.
1470 Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway.Evid Based Complement Alternat Med. 2019 Sep 18;2019:8260815. doi: 10.1155/2019/8260815. eCollection 2019.
1471 Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis.Stem Cell Reports. 2018 Feb 13;10(2):347-355. doi: 10.1016/j.stemcr.2017.12.010. Epub 2018 Jan 11.
1472 Candidate gene discovery procedure after follow-up confirmatory analyses of candidate regions of interests for Alzheimer's disease in the NIMH sibling dataset.Dis Markers. 2008;24(6):293-309. doi: 10.1155/2008/736409.
1473 Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease.Exp Neurol. 1997 Oct;147(2):316-32. doi: 10.1006/exnr.1997.6600.
1474 Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease.Neurobiol Dis. 2012 Mar;45(3):902-12. doi: 10.1016/j.nbd.2011.12.007. Epub 2011 Dec 11.
1475 Protective effect of ISO? against advanced glycation end product aggravation of PC12 cell injury induced by A1?0.Mol Med Rep. 2019 Sep;20(3):2135-2142. doi: 10.3892/mmr.2019.10483. Epub 2019 Jul 9.
1476 Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.J Biol Chem. 2009 Jan 9;284(2):1106-15. doi: 10.1074/jbc.M807325200. Epub 2008 Nov 18.
1477 Double stranded RNA activated EIF2 alpha kinase (EIF2AK2; PKR) is associated with Alzheimer's disease.Neurobiol Aging. 2008 Aug;29(8):1160-6. doi: 10.1016/j.neurobiolaging.2007.02.023. Epub 2007 Apr 8.
1478 Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.PLoS Genet. 2011 Feb;7(2):e1001308. doi: 10.1371/journal.pgen.1001308. Epub 2011 Feb 17.
1479 eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.PLoS One. 2010 Sep 28;5(9):e13030. doi: 10.1371/journal.pone.0013030.
1480 Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.Brain Pathol. 2016 Sep;26(5):593-605. doi: 10.1111/bpa.12335. Epub 2015 Dec 14.
1481 Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective.Genomics. 2020 Mar;112(2):1290-1299. doi: 10.1016/j.ygeno.2019.07.018. Epub 2019 Aug 1.
1482 HuD regulates coding and noncoding RNA to induce APPA processing.Cell Rep. 2014 Jun 12;7(5):1401-1409. doi: 10.1016/j.celrep.2014.04.050. Epub 2014 May 22.
1483 Protein inhibitor of activated STAT1 Ser(503) phosphorylation-mediated Elk-1 SUMOylation promotes neuronal survival in APP/PS1 mice.Br J Pharmacol. 2019 Jun;176(11):1793-1810. doi: 10.1111/bph.14656. Epub 2019 Apr 24.
1484 Evidence of recessive Alzheimer disease loci in a Caribbean Hispanic data set: genome-wide survey of runs of homozygosity.JAMA Neurol. 2013 Oct;70(10):1261-7. doi: 10.1001/jamaneurol.2013.3545.
1485 5-HT1B and other related serotonergic proteins are altered in APPswe mutation. Neurosci Lett. 2015 May 6;594:137-43.
1486 Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Brain Res. 2009 Jun 5;1274:66-76. doi: 10.1016/j.brainres.2009.04.009. Epub 2009 Apr 15.
1487 Non-parametric Survival Analysis of EPG5 Gene with Age at Onset of Alzheimer's Disease.J Mol Neurosci. 2016 Dec;60(4):436-444. doi: 10.1007/s12031-016-0821-9. Epub 2016 Sep 1.
1488 Quantitative proteomics reveals EVA1A-related proteins involved in neuronal differentiation.Proteomics. 2017 Mar;17(5). doi: 10.1002/pmic.201600294. Epub 2017 Feb 21.
1489 Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer's disease.BMC Med Genomics. 2018 Sep 14;11(Suppl 3):76. doi: 10.1186/s12920-018-0390-6.
1490 Increased ileal bile acid binding protein and galectin-9 are associated with mild cognitive impairment and Alzheimer's disease.J Psychiatr Res. 2019 Dec;119:102-106. doi: 10.1016/j.jpsychires.2019.10.002. Epub 2019 Oct 3.
1491 FABP7 Protects Astrocytes Against ROS Toxicity via Lipid Droplet Formation.Mol Neurobiol. 2019 Aug;56(8):5763-5779. doi: 10.1007/s12035-019-1489-2. Epub 2019 Jan 24.
1492 Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease.ACS Chem Neurosci. 2019 Aug 21;10(8):3611-3621. doi: 10.1021/acschemneuro.9b00216. Epub 2019 Jun 12.
1493 Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease.Neuroscience. 2016 Aug 25;330:236-46. doi: 10.1016/j.neuroscience.2016.05.050. Epub 2016 May 30.
1494 Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.FEBS Lett. 2009 Oct 6;583(19):3247-53. doi: 10.1016/j.febslet.2009.09.018. Epub 2009 Sep 13.
1495 Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes.Int J Mol Sci. 2013 Jun 10;14(6):12380-400. doi: 10.3390/ijms140612380.
1496 Neuronal expression of F-box and leucine-rich-repeat protein 2 decreases over Braak stages in the brains of Alzheimer's disease patients.Neurodegener Dis. 2013;11(1):1-12. doi: 10.1159/000336016. Epub 2012 Mar 27.
1497 F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease.Ann Clin Transl Neurol. 2015 Aug;2(8):810-20. doi: 10.1002/acn3.223. Epub 2015 Jun 18.
1498 SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.Aging Cell. 2010 Dec;9(6):1018-31. doi: 10.1111/j.1474-9726.2010.00632.x. Epub 2010 Oct 29.
1499 F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy.Hum Mol Genet. 2015 Nov 15;24(22):6314-30. doi: 10.1093/hmg/ddv340. Epub 2015 Aug 26.
1500 Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in A and TAU proteostasis.Hum Mol Genet. 2019 Mar 1;28(5):718-735. doi: 10.1093/hmg/ddy376.
1501 Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau.PLoS One. 2019 Jan 4;14(1):e0209573. doi: 10.1371/journal.pone.0209573. eCollection 2019.
1502 Fibroblast Growth Factor 9 Suppresses Striatal Cell Death Dominantly Through ERK Signaling in Huntington's Disease.Cell Physiol Biochem. 2018;48(2):605-617. doi: 10.1159/000491889. Epub 2018 Jul 18.
1503 Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.Hum Mol Genet. 2000 Sep 22;9(15):2281-9. doi: 10.1093/oxfordjournals.hmg.a018919.
1504 Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.Oncotarget. 2017 Dec 22;9(5):6128-6143. doi: 10.18632/oncotarget.23640. eCollection 2018 Jan 19.
1505 Pin1 facilitates isoproterenolinduced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2ERK1/2 signal transduction pathway in rats.Int J Mol Med. 2018 Mar;41(3):1573-1583. doi: 10.3892/ijmm.2017.3354. Epub 2017 Dec 29.
1506 The Value of FLG Null Mutations in Predicting Treatment Response in Atopic Dermatitis: An Observational Study in Finnish Patients.Acta Derm Venereol. 2017 Apr 6;97(4):456-463. doi: 10.2340/00015555-2578.
1507 In silico-guided identification of potential inhibitors against (2)m aggregation in dialysis-related amyloidosis.J Biomol Struct Dyn. 2020 Aug;38(13):3927-3941. doi: 10.1080/07391102.2019.1668852. Epub 2019 Sep 27.
1508 Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.EMBO J. 2017 Oct 2;36(19):2815-2828. doi: 10.15252/embj.201796821. Epub 2017 Aug 2.
1509 Fragile X gene expansions are not associated with dementia.Neurobiol Aging. 2014 Nov;35(11):2637-2638. doi: 10.1016/j.neurobiolaging.2014.04.027. Epub 2014 May 2.
1510 Mechanistic complexities of bone loss in Alzheimer's disease: a review.Connect Tissue Res. 2020 Jan;61(1):4-18. doi: 10.1080/03008207.2019.1624734. Epub 2019 Jun 11.
1511 KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.Brain. 2012 Apr;135(Pt 4):1027-41. doi: 10.1093/brain/aws045. Epub 2012 Mar 16.
1512 Genome-wide profiling reveals functional diversification of FosB gene targets in the hippocampus of an Alzheimer's disease mouse model.PLoS One. 2018 Feb 6;13(2):e0192508. doi: 10.1371/journal.pone.0192508. eCollection 2018.
1513 Meta-Analysis of Transcriptome Data Related to Hippocampus Biopsies and iPSC-Derived Neuronal Cells from Alzheimer's Disease Patients Reveals an Association with FOXA1 and FOXA2 Gene Regulatory Networks.J Alzheimers Dis. 2016;50(4):1065-82. doi: 10.3233/JAD-150733.
1514 No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease.Neurosci Lett. 2004 Apr 22;360(1-2):109-11. doi: 10.1016/j.neulet.2004.02.046.
1515 Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models.Neurobiol Aging. 2015 Feb;36(2):1221.e15-28. doi: 10.1016/j.neurobiolaging.2014.09.003. Epub 2014 Sep 6.
1516 Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.Hum Mutat. 2012 Mar;33(3):521-9. doi: 10.1002/humu.22009. Epub 2012 Jan 23.
1517 Mitochondrial Ferritin Deletion Exacerbates -Amyloid-Induced Neurotoxicity in Mice.Oxid Med Cell Longev. 2017;2017:1020357. doi: 10.1155/2017/1020357. Epub 2017 Jan 16.
1518 Relevance of Follow-Up in Patients with Core Clinical Criteria for Alzheimer Disease and Normal CSF Biomarkers.Curr Alzheimer Res. 2018;15(7):691-700. doi: 10.2174/1567205015666180110113238.
1519 A serial analysis of gene expression profile of the Alzheimer's disease Tg2576 mouse model.Neurotox Res. 2010 May;17(4):360-79. doi: 10.1007/s12640-009-9112-3. Epub 2009 Sep 16.
1520 Silencing of Long Noncoding RNA SOX21-AS1 Relieves Neuronal Oxidative Stress Injury in Mice with Alzheimer's Disease by Upregulating FZD3/5 via the Wnt Signaling Pathway.Mol Neurobiol. 2019 May;56(5):3522-3537. doi: 10.1007/s12035-018-1299-y. Epub 2018 Aug 24.
1521 WNT5A signaling contributes to A-induced neuroinflammation and neurotoxicity.PLoS One. 2011;6(8):e22920. doi: 10.1371/journal.pone.0022920. Epub 2011 Aug 17.
1522 Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function.Cereb Cortex. 2018 Jul 1;28(7):2391-2404. doi: 10.1093/cercor/bhx141.
1523 Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging.Acta Neuropathol. 2005 May;109(5):467-74. doi: 10.1007/s00401-005-0985-9. Epub 2005 Mar 10.
1524 NF-E2-related factor 2 activation boosts antioxidant defenses and ameliorates inflammatory and amyloid properties in human Presenilin-1 mutated Alzheimer's disease astrocytes.Glia. 2020 Mar;68(3):589-599. doi: 10.1002/glia.23741. Epub 2019 Oct 31.
1525 Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients.J Cell Sci. 2002 Aug 1;115(Pt 15):3131-8. doi: 10.1242/jcs.115.15.3131.
1526 CR6-interacting factor 1 is a key regulator in A-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.Cell Death Differ. 2015 Jun;22(6):959-73. doi: 10.1038/cdd.2014.184. Epub 2014 Nov 7.
1527 Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP/PS1 transgenic mice.Int J Immunopathol Pharmacol. 2019 Jan-Dec;33:2058738419841482. doi: 10.1177/2058738419841482.
1528 Solution NMR structure and ligand identification of human Gas7 SH3 domain reveal a typical SH3 fold but a non-canonical ligand-binding mode.Biochem Biophys Res Commun. 2019 Sep 3;516(4):1190-1195. doi: 10.1016/j.bbrc.2019.07.004. Epub 2019 Jul 9.
1529 Regulatory role of Golgi brefeldin A resistance factor-1 in amyloid precursor protein trafficking, cleavage and A formation.J Cell Biochem. 2019 Sep;120(9):15604-15615. doi: 10.1002/jcb.28827. Epub 2019 May 20.
1530 Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications.Sci Rep. 2017 Apr 18;7:46263. doi: 10.1038/srep46263.
1531 MiR-16 attenuates -amyloid-induced neurotoxicity through targeting -site amyloid precursor protein-cleaving enzyme 1 in an Alzheimer's disease cell model.Neuroreport. 2018 Nov 7;29(16):1365-1372. doi: 10.1097/WNR.0000000000001118.
1532 GDF11 Rejuvenates Cerebrovascular Structure and Function in an Animal Model of Alzheimer's Disease.J Alzheimers Dis. 2018;62(2):807-819. doi: 10.3233/JAD-170474.
1533 Synergistic promoting effects of bone morphogenetic protein 12/connective tissue growth factor on functional differentiation of tendon derived stem cells and patellar tendon window defect regeneration.J Biomech. 2018 Jan 3;66:95-102. doi: 10.1016/j.jbiomech.2017.11.004. Epub 2017 Nov 7.
1534 Deficiency of GDNF Receptor GFR1 in Alzheimer's Neurons Results in Neuronal Death.J Neurosci. 2014 Sep 24;34(39):13127-38. doi: 10.1523/JNEUROSCI.2582-13.2014.
1535 Role of human GKN1 on APP processing in gastric cancer.Biochimie. 2017 Apr;135:149-153. doi: 10.1016/j.biochi.2017.02.007. Epub 2017 Feb 16.
1536 Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers.Acta Neuropathol. 2017 May;133(5):839-856. doi: 10.1007/s00401-017-1685-y. Epub 2017 Feb 28.
1537 Identifying potential GluN2B subunit containing N-Methyl-D-aspartate receptor inhibitors: an integrative in silico and molecular modeling approach.J Biomol Struct Dyn. 2020 Jun;38(9):2533-2545. doi: 10.1080/07391102.2019.1635530. Epub 2019 Jul 4.
1538 Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer's Disease Therapeutic Target.Mol Neurobiol. 2019 Jan;56(1):378-393. doi: 10.1007/s12035-018-1068-y. Epub 2018 Apr 27.
1539 GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.Neuron. 2013 Apr 24;78(2):256-68. doi: 10.1016/j.neuron.2013.02.026. Epub 2013 Apr 4.
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1541 Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin.Int J Nanomedicine. 2017 Apr 7;12:2857-2869. doi: 10.2147/IJN.S132472. eCollection 2017.
1542 Polymorphism in genes involved in adrenergic signaling associated with Alzheimer's.Neurobiol Aging. 2004 Aug;25(7):853-9. doi: 10.1016/j.neurobiolaging.2003.10.006.
1543 Reduction of Ether-Type Glycerophospholipids, Plasmalogens, by NF-B Signal Leading to Microglial Activation.J Neurosci. 2017 Apr 12;37(15):4074-4092. doi: 10.1523/JNEUROSCI.3941-15.2017. Epub 2017 Mar 14.
1544 Novel genetic tools reveal Cdk5's major role in Golgi fragmentation in Alzheimer's disease.Mol Biol Cell. 2008 Jul;19(7):3052-69. doi: 10.1091/mbc.e07-11-1106. Epub 2008 May 14.
1545 Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease.Neurology. 2018 Nov 6;91(19):e1799-e1808. doi: 10.1212/WNL.0000000000006457. Epub 2018 Oct 10.
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1548 Tuning GABAergic Inhibition: Gephyrin Molecular Organization and Functions.Neuroscience. 2020 Jul 15;439:125-136. doi: 10.1016/j.neuroscience.2019.07.036. Epub 2019 Jul 26.
1549 The Membrane Glycoprotein M6a Endocytic/Recycling Pathway Involves Clathrin-Mediated Endocytosis and Affects Neuronal Synapses.Front Mol Neurosci. 2017 Sep 20;10:296. doi: 10.3389/fnmol.2017.00296. eCollection 2017.
1550 Significant association between GPR50 hypomethylation and AD in males.Mol Med Rep. 2019 Aug;20(2):1085-1092. doi: 10.3892/mmr.2019.10366. Epub 2019 Jun 6.
1551 Amyloid beta protein-related death-inducing protein induces G2/M arrest: Implications for neurodegeneration in Alzheimer's disease. J Neurosci Res. 2007 Aug 1;85(10):2262-71. doi: 10.1002/jnr.21351.
1552 Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease.Mol Psychiatry. 2013 May;18(5):568-75. doi: 10.1038/mp.2012.81. Epub 2012 Jun 19.
1553 Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides A(1-42) and Tau Proteins in Elderly Patients With Mild Cognitive Impairment.Front Aging Neurosci. 2018 Oct 1;10:297. doi: 10.3389/fnagi.2018.00297. eCollection 2018.
1554 Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.Dement Geriatr Cogn Disord. 2009;28(6):521-7. doi: 10.1159/000254757. Epub 2009 Dec 10.
1555 Structural insight into GRIP1-PDZ6 in Alzheimer's disease: study from protein expression data to molecular dynamics simulations.J Biomol Struct Dyn. 2017 Aug;35(10):2235-2247. doi: 10.1080/07391102.2016.1214085. Epub 2016 Aug 1.
1556 In silico identification of natural product inhibitors for -secretase activating protein, a therapeutic target for Alzheimer's disease.J Cell Biochem. 2019 Jun;120(6):10323-10336. doi: 10.1002/jcb.28316. Epub 2018 Dec 19.
1557 GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease.J Clin Med. 2019 Oct 21;8(10):1751. doi: 10.3390/jcm8101751.
1558 Explorative genetic association study of GSTT2B copy number variant in complex disease risks.Ann Hum Biol. 2016 May;43(3):279-84. doi: 10.3109/03014460.2015.1049206. Epub 2015 Jul 24.
1559 MicroRNA-132 promotes neurons cell apoptosis and activates Tau phosphorylation by targeting GTDC-1 in Alzheimer's disease.Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8523-8532. doi: 10.26355/eurrev_201910_19166.
1560 GULP1/CED-6 ameliorates amyloid- toxicity in a Drosophila model of Alzheimer's disease.Oncotarget. 2017 Aug 8;8(59):99274-99283. doi: 10.18632/oncotarget.20062. eCollection 2017 Nov 21.
1561 Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, -GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment.Brain Res. 2017 Jan 1;1654(Pt A):66-76. doi: 10.1016/j.brainres.2016.10.011. Epub 2016 Oct 17.
1562 Long-standing balancing selection in the THBS4 gene: influence on sex-specific brain expression and gray matter volumes in Alzheimer disease.Hum Mutat. 2013 May;34(5):743-53. doi: 10.1002/humu.22301. Epub 2013 Apr 2.
1563 Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.Alzheimers Dement. 2015 Dec;11(12):1439-1451. doi: 10.1016/j.jalz.2015.05.015. Epub 2015 Jun 12.
1564 Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases.J Alzheimers Dis. 2017;57(2):395-409. doi: 10.3233/JAD-160804.
1565 Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease.Neurobiol Aging. 2008 Feb;29(2):185-93. doi: 10.1016/j.neurobiolaging.2006.10.017. Epub 2006 Dec 8.
1566 Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with A in a mice model of early-stage Alzheimer's disease.Neurobiol Dis. 2019 Dec;132:104603. doi: 10.1016/j.nbd.2019.104603. Epub 2019 Sep 5.
1567 HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.BMC Med Genet. 2009 Sep 15;10:90. doi: 10.1186/1471-2350-10-90.
1568 MicroRNA-98 reduces amyloid -protein production and improves oxidative stress and mitochondrial dysfunction through the Notch signaling pathway via HEY2 in Alzheimer's disease mice.Int J Mol Med. 2019 Jan;43(1):91-102. doi: 10.3892/ijmm.2018.3957. Epub 2018 Oct 24.
1569 HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study.PLoS Med. 2015 Jul 14;12(7):e1001853. doi: 10.1371/journal.pmed.1001853. eCollection 2015 Jul.
1570 Immune hyperreactivity of A plaque-associated microglia in Alzheimer's disease.Neurobiol Aging. 2017 Jul;55:115-122. doi: 10.1016/j.neurobiolaging.2017.03.021. Epub 2017 Mar 27.
1571 Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population.Oncotarget. 2017 Apr 11;8(15):24077-24087. doi: 10.18632/oncotarget.15269.
1572 Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease.Mol Neurobiol. 2016 Jul;53(5):3227-3234. doi: 10.1007/s12035-015-9229-8. Epub 2015 Jun 6.
1573 MicroRNA 7 Impairs Insulin Signaling and Regulates A Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway.Mol Cell Biol. 2019 Oct 28;39(22):e00170-19. doi: 10.1128/MCB.00170-19. Print 2019 Nov 15.
1574 Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease.Brain. 2016 Feb;139(Pt 2):526-46. doi: 10.1093/brain/awv356. Epub 2015 Dec 14.
1575 Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.PLoS One. 2015 Mar 23;10(3):e0119423. doi: 10.1371/journal.pone.0119423. eCollection 2015.
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1578 Production of transgenic pig as an Alzheimer's disease model using a multi-cistronic vector system.PLoS One. 2017 Jun 6;12(6):e0177933. doi: 10.1371/journal.pone.0177933. eCollection 2017.
1579 Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer's Disease.J Alzheimers Dis. 2017;58(1):185-192. doi: 10.3233/JAD-161298.
1580 Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease.Circulation. 2015 Jun 9;131(23):2061-2069. doi: 10.1161/CIRCULATIONAHA.115.015489. Epub 2015 Apr 10.
1581 HSP70-2 (HSPA1B) is associated with noncognitive symptoms in late-onset Alzheimer's disease.J Geriatr Psychiatry Neurol. 2003 Sep;16(3):146-50. doi: 10.1177/0891988703256051.
1582 The Effect of Human HSP70 Administration on a Mouse Model of Alzheimer's Disease Strongly Depends on Transgenicity and Age.J Alzheimers Dis. 2019;67(4):1391-1404. doi: 10.3233/JAD-180987.
1583 The phosphorylation of Hsp20 enhances its association with amyloid- to increase protection against neuronal cell death.Mol Cell Neurosci. 2014 Jul;61:46-55. doi: 10.1016/j.mcn.2014.05.002. Epub 2014 May 20.
1584 Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta.Mol Cell Biol. 2010 Oct;30(19):4626-43. doi: 10.1128/MCB.01493-09. Epub 2010 Aug 2.
1585 Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.Mol Neurobiol. 2019 Jul;56(7):4601-4619. doi: 10.1007/s12035-018-1383-3. Epub 2018 Oct 25.
1586 Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease.Life Sci. 2018 Aug 15;207:428-435. doi: 10.1016/j.lfs.2018.06.032. Epub 2018 Jun 30.
1587 ORP150-CHIP chaperone antagonism control BACE1-mediated amyloid processing.J Cell Biochem. 2018 Jun;119(6):4615-4626. doi: 10.1002/jcb.26630. Epub 2018 Feb 27.
1588 Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.PLoS One. 2018 May 8;13(5):e0196929. doi: 10.1371/journal.pone.0196929. eCollection 2018.
1589 Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.Eur J Med Chem. 2017 Jan 5;125:736-750. doi: 10.1016/j.ejmech.2016.09.057. Epub 2016 Sep 19.
1590 Expression of ced-3 and ced-9 homologs in Alzheimer's disease cerebral cortex.Neurosci Lett. 1998 Mar 13;244(2):69-72. doi: 10.1016/s0304-3940(98)00138-4.
1591 SH3-binding protein 5 mediates the neuroprotective effect of the secreted bioactive peptide humanin by inhibiting c-Jun NH2-terminal kinase.J Biol Chem. 2013 Aug 23;288(34):24691-704. doi: 10.1074/jbc.M113.469692. Epub 2013 Jul 16.
1592 Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor.Cell Death Dis. 2013 Mar 21;4(3):e555. doi: 10.1038/cddis.2013.80.
1593 IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis.PLoS One. 2012;7(3):e33271. doi: 10.1371/journal.pone.0033271. Epub 2012 Mar 8.
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1595 A Novel Microtubule-Tau Association Enhancer and Neuroprotective Drug Candidate: Ac-SKIP.Front Cell Neurosci. 2019 Oct 1;13:435. doi: 10.3389/fncel.2019.00435. eCollection 2019.
1596 Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.J Neurochem. 2007 May;101(3):757-70. doi: 10.1111/j.1471-4159.2006.04368.x.
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1598 Enhanced tau pathology via RanBP9 and Hsp90/Hsc70 chaperone complexes.Hum Mol Genet. 2017 Oct 15;26(20):3973-3988. doi: 10.1093/hmg/ddx284.
1599 LPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning.J Neuroimmunol. 2017 Dec 15;313:1-9. doi: 10.1016/j.jneuroim.2017.09.010. Epub 2017 Sep 28.
1600 Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease.J Alzheimers Dis. 2006 Aug;9(3):225-33. doi: 10.3233/jad-2006-9301.
1601 LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.Brain. 2005 Aug;128(Pt 8):1778-89. doi: 10.1093/brain/awh531. Epub 2005 Apr 27.
1602 Variants in Antiviral Genes are Risk Factors for Cognitive Decline and Dementia.J Alzheimers Dis. 2015;46(3):655-63. doi: 10.3233/JAD-142718.
1603 Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease.BMC Genomics. 2013 Nov 25;14:831. doi: 10.1186/1471-2164-14-831.
1604 Differential Phagocytic Properties of CD45(low) Microglia and CD45(high) Brain Mononuclear Phagocytes-Activation and Age-Related Effects.Front Immunol. 2018 Mar 2;9:405. doi: 10.3389/fimmu.2018.00405. eCollection 2018.
1605 Extracellular Vesicles: A Possible Link between HIV and Alzheimer's Disease-Like Pathology in HIV Subjects?.Cells. 2019 Aug 24;8(9):968. doi: 10.3390/cells8090968.
1606 miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.EMBO Mol Med. 2016 Sep 1;8(9):1005-18. doi: 10.15252/emmm.201606520. Print 2016 Sep.
1607 Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome.Neuroreport. 2011 Oct 26;22(15):767-72. doi: 10.1097/WNR.0b013e32834ae348.
1608 Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers.Eur J Neurosci. 2019 May;49(9):1091-1101. doi: 10.1111/ejn.14311. Epub 2019 Jan 20.
1609 The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease.Mol Pharmacol. 2007 Sep;72(3):499-501. doi: 10.1124/mol.107.039206. Epub 2007 Jun 26.
1610 Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis.Front Mol Neurosci. 2018 Dec 3;11:449. doi: 10.3389/fnmol.2018.00449. eCollection 2018.
1611 The Brief Memory and Executive Test (BMET): A cognitive screening tool to detect and differentiate vascular cognitive impairment and Alzheimer's disease.Int J Geriatr Psychiatry. 2018 Feb;33(2):e273-e279. doi: 10.1002/gps.4787. Epub 2017 Sep 7.
1612 Genome-wide association interaction analysis for Alzheimer's disease.Neurobiol Aging. 2014 Nov;35(11):2436-2443. doi: 10.1016/j.neurobiolaging.2014.05.014. Epub 2014 May 28.
1613 microRNA-592 blockade inhibits oxidative stress injury in Alzheimer's disease astrocytes via the KIAA0319-mediated Keap1/Nrf2/ARE signaling pathway.Exp Neurol. 2020 Feb;324:113128. doi: 10.1016/j.expneurol.2019.113128. Epub 2019 Nov 21.
1614 Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.Aging (Albany NY). 2016 Feb;8(2):272-90. doi: 10.18632/aging.100887.
1615 Kidins220 Correlates with Tau inAlzheimer's Disease Brain andCerebrospinal Fluid.J Alzheimers Dis. 2017;55(4):1327-1333. doi: 10.3233/JAD-160639.
1616 Single nucleotide polymorphisms in piRNA-pathway genes: an insight into genetic determinants of human diseases.Mol Genet Genomics. 2020 Jan;295(1):1-12. doi: 10.1007/s00438-019-01612-5. Epub 2019 Oct 14.
1617 Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.J Alzheimers Dis. 2017;60(4):1511-1524. doi: 10.3233/JAD-170094.
1618 KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients.J Alzheimers Dis. 2013;33(1):111-6. doi: 10.3233/JAD-2012-121015.
1619 Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.Acta Neuropathol Commun. 2019 Dec 5;7(1):200. doi: 10.1186/s40478-019-0857-5.
1620 MicroRNA-25 aggravates A1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model.J Cell Biochem. 2019 Sep;120(9):15891-15905. doi: 10.1002/jcb.28861. Epub 2019 May 29.
1621 Krppel-like factor 8 ameliorates Alzheimer's disease by activating -catenin.J Mol Neurosci. 2014 Feb;52(2):231-41. doi: 10.1007/s12031-013-0131-4. Epub 2013 Oct 11.
1622 Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.Structure. 2019 Sep 3;27(9):1395-1404.e4. doi: 10.1016/j.str.2019.06.005. Epub 2019 Jul 3.
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1624 Buccal cell cytokeratin 14 identifies mild cognitive impairment and Alzheimer' s disease in the AIBL study of aging.Curr Alzheimer Res. 2015;12(3):233-41. doi: 10.2174/1567205012666150302154650.
1625 Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells.Nano Lett. 2017 Jan 11;17(1):143-149. doi: 10.1021/acs.nanolett.6b03686. Epub 2016 Dec 8.
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1627 Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid- accumulation in Alzheimer's disease.Hum Genet. 2018 Jul;137(6-7):521-533. doi: 10.1007/s00439-018-1906-z. Epub 2018 Jul 13.
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1630 Association between Single-Nucleotide Polymorphisms of the hOGG1,NEIL1,APEX1, FEN1,LIG1, and LIG3 Genes and Alzheimer's Disease Risk.Neuropsychobiology. 2016;73(2):98-107. doi: 10.1159/000444643. Epub 2016 Mar 25.
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1633 Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer's Disease and Amnesic Mild Cognitive Impairment.PLoS One. 2016 Jan 7;11(1):e0146449. doi: 10.1371/journal.pone.0146449. eCollection 2016.
1634 Postsynaptic density protein PSD-95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction.Neurobiol Dis. 2008 Jun;30(3):408-419. doi: 10.1016/j.nbd.2008.02.012. Epub 2008 Mar 12.
1635 Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body disease.Sci Rep. 2019 Nov 20;9(1):17222. doi: 10.1038/s41598-019-53638-9.
1636 Upregulation of microRNA-196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression.J Cell Biochem. 2019 Oct;120(10):17811-17821. doi: 10.1002/jcb.29047. Epub 2019 May 22.
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1638 Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals.Oncotarget. 2015 Dec 15;6(40):42504-14. doi: 10.18632/oncotarget.6391.
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1640 Association of LRRTM3 polymorphisms with late-onset Alzheimer's disease in Han Chinese.Exp Gerontol. 2014 Apr;52:18-22. doi: 10.1016/j.exger.2014.01.013. Epub 2014 Jan 21.
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1642 U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease.Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16562-7. doi: 10.1073/pnas.1310249110. Epub 2013 Sep 10.
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1645 Lynx1 and A1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.Neurobiol Aging. 2016 Oct;46:13-21. doi: 10.1016/j.neurobiolaging.2016.06.009. Epub 2016 Jun 17.
1646 Alteration of scaffold: Possible role of MACF1 in Alzheimer's disease pathogenesis.Med Hypotheses. 2019 Sep;130:109259. doi: 10.1016/j.mehy.2019.109259. Epub 2019 Jun 5.
1647 Meta-Analysis of Parkinson's Disease and Alzheimer's Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes.J Alzheimers Dis. 2017;56(4):1525-1539. doi: 10.3233/JAD-161032.
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1650 Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR- in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice.Mol Cell Neurosci. 2019 Sep;99:103390. doi: 10.1016/j.mcn.2019.103390. Epub 2019 Jul 2.
1651 Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers.Front Aging Neurosci. 2018 May 29;10:155. doi: 10.3389/fnagi.2018.00155. eCollection 2018.
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1653 Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.J Cell Biol. 2017 Oct 2;216(10):3291-3305. doi: 10.1083/jcb.201612148. Epub 2017 Aug 7.
1654 N-homocysteinylation of tau and MAP1 is increased in autopsy specimens of Alzheimer's disease and vascular dementia.J Pathol. 2019 Jul;248(3):291-303. doi: 10.1002/path.5254. Epub 2019 Mar 19.
1655 A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro.J Biol Chem. 2018 Jul 20;293(29):11424-11432. doi: 10.1074/jbc.RA117.001628. Epub 2018 May 31.
1656 Mitochondrial calcium uniporter as a potential therapeutic strategy for Alzheimer's disease.Acta Neuropsychiatr. 2020 Apr;32(2):65-71. doi: 10.1017/neu.2019.39. Epub 2019 Dec 26.
1657 Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.EMBO Rep. 2011 Mar;12(3):216-22. doi: 10.1038/embor.2010.210. Epub 2011 Feb 4.
1658 Genetic risk for Alzheimer's disease is concentrated in specific macrophage and microglial transcriptional networks.Genome Med. 2018 Feb 26;10(1):14. doi: 10.1186/s13073-018-0523-8.
1659 MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease.Psychiatry Clin Neurosci. 2018 Mar;72(3):160-167. doi: 10.1111/pcn.12618. Epub 2017 Dec 1.
1660 -synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.Neurobiol Dis. 2011 Jan;41(1):71-82. doi: 10.1016/j.nbd.2010.08.022. Epub 2010 Sep 9.
1661 Short-Term Fish Oil Treatment Changes the Composition of Phospholipids While Not Affecting the Expression of Mfsd2a Omega-3 Transporter in the Brain and Liver of the 5xFAD Mouse Model of Alzheimer's Disease.Nutrients. 2018 Sep 6;10(9):1250. doi: 10.3390/nu10091250.
1662 An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.EMBO Mol Med. 2015 Feb;7(2):175-89. doi: 10.15252/emmm.201404438.
1663 Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex.Sci Rep. 2017 Oct 23;7(1):13753. doi: 10.1038/s41598-017-12974-4.
1664 Three-way interaction model to trace the mechanisms involved in Alzheimer's disease transgenic mice.PLoS One. 2017 Sep 21;12(9):e0184697. doi: 10.1371/journal.pone.0184697. eCollection 2017.
1665 Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease.Brain Pathol. 2017 Mar;27(2):160-168. doi: 10.1111/bpa.12369. Epub 2016 Apr 6.
1666 Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease.Acta Neuropathol. 2020 Mar;139(3):463-484. doi: 10.1007/s00401-019-02103-y. Epub 2019 Dec 4.
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1668 Emerging Alternative Proteinases in APP Metabolism and Alzheimer's Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP.Front Aging Neurosci. 2019 Sep 24;11:244. doi: 10.3389/fnagi.2019.00244. eCollection 2019.
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1670 Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain.BMC Biol. 2017 Jun 29;15(1):54. doi: 10.1186/s12915-017-0387-1.
1671 Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models.FASEB J. 2009 Sep;23(9):2820-30. doi: 10.1096/fj.08-120410. Epub 2009 Apr 15.
1672 Wechsler adult intelligence scale-4th edition digit span performance in subjective cognitive complaints, amnestic mild cognitive impairment, and probable dementia of the Alzheimer type.Clin Neuropsychol. 2019 Nov;33(8):1436-1444. doi: 10.1080/13854046.2019.1585574. Epub 2019 Mar 31.
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1674 MS4A Cluster in Alzheimer's Disease.Mol Neurobiol. 2015;51(3):1240-8. doi: 10.1007/s12035-014-8800-z. Epub 2014 Jul 1.
1675 Gene-based aggregate SNP associations between candidate AD genes and cognitive decline.Age (Dordr). 2016 Apr;38(2):41. doi: 10.1007/s11357-016-9885-2. Epub 2016 Mar 22.
1676 Intrahippocampal Transplantation of Undifferentiated Human Chorionic- Derived Mesenchymal Stem Cells Does Not Improve Learning and Memory in the Rat Model of Sporadic Alzheimer Disease.Curr Stem Cell Res Ther. 2019;14(2):184-190. doi: 10.2174/1574888X13666180723111249.
1677 Methionine Sulfoxide Reductase-B3 Risk Allele Implicated in Alzheimer's Disease Associates with Increased Odds for Brain Infarcts.J Alzheimers Dis. 2019;68(1):357-365. doi: 10.3233/JAD-180977.
1678 Metal-dependent interactions of metallothionein-3 -domain with amyloid- peptide and related physiological implications.J Inorg Biochem. 2019 Jul;196:110693. doi: 10.1016/j.jinorgbio.2019.110693. Epub 2019 Apr 13.
1679 Loss of forebrain MTCH2 decreases mitochondria motility and calcium handling and impairs hippocampal-dependent cognitive functions.Sci Rep. 2017 Mar 9;7:44401. doi: 10.1038/srep44401.
1680 Overexpression of MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10.Biochem Biophys Res Commun. 2017 Jan 22;482(4):928-934. doi: 10.1016/j.bbrc.2016.11.135. Epub 2016 Nov 25.
1681 Association analysis of CbetaS 844ins68 and MTHFD1 G1958A polymorphisms with Alzheimer's disease in Chinese.J Neural Transm (Vienna). 2010 Apr;117(4):499-503. doi: 10.1007/s00702-010-0383-x. Epub 2010 Mar 9.
1682 MxA polymorphisms are associated with risk and age-at-onset in Alzheimer disease and accelerated cognitive decline in Chinese elders.Rejuvenation Res. 2012 Oct;15(5):516-22. doi: 10.1089/rej.2012.1328. Epub 2012 Sep 21.
1683 Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.Brain Res. 2010 Jul 23;1345:182-9. doi: 10.1016/j.brainres.2010.05.007. Epub 2010 May 10.
1684 Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process.Neurobiol Aging. 2017 May;53:59-66. doi: 10.1016/j.neurobiolaging.2017.01.011. Epub 2017 Jan 18.
1685 The E3 ubiquitin ligase inducible degrader of the LDL receptor/myosin light chain interacting protein in health and disease.Curr Opin Lipidol. 2019 Jun;30(3):192-197. doi: 10.1097/MOL.0000000000000593.
1686 Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.Alzheimers Res Ther. 2019 Jan 12;11(1):5. doi: 10.1186/s13195-018-0458-8.
1687 Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):823-8. doi: 10.1073/pnas.0608251104. Epub 2007 Jan 10.
1688 Pituitary adenylate cyclase-activating polypeptide protects against -amyloid toxicity.Neurobiol Aging. 2014 Sep;35(9):2064-71. doi: 10.1016/j.neurobiolaging.2014.03.022. Epub 2014 Mar 22.
1689 Haplotype of single nucleotide polymorphisms in exon 6 of the MZF-1 gene and Alzheimer's disease.J Alzheimers Dis. 2013;34(2):439-47. doi: 10.3233/JAD-121546.
1690 Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.J Investig Med. 2002 Jul;50(4):293-301. doi: 10.2310/6650.2002.33287.
1691 Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.J Neurosci. 2007 Jul 4;27(27):7141-53. doi: 10.1523/JNEUROSCI.4599-06.2007.
1692 Role of aberrant nitric oxide synthase-3 expression in cerebrovascular degeneration and vascular-mediated injury in Alzheimer's disease.Ann N Y Acad Sci. 2000 Apr;903:61-71. doi: 10.1111/j.1749-6632.2000.tb06351.x.
1693 A Multifunctional Biocompatible Drug Candidate is Highly Effective in Delaying Pathological Signs of Alzheimer's Disease in 5XFAD Mice.J Alzheimers Dis. 2017;58(2):389-400. doi: 10.3233/JAD-161236.
1694 Alzheimer's Disease Risk Variant rs2373115 Regulates GAB2 and NARS2 Expression in Human Brain Tissues.J Mol Neurosci. 2018 Sep;66(1):37-43. doi: 10.1007/s12031-018-1144-9. Epub 2018 Aug 7.
1695 Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease.J Neuroimmunol. 2017 Sep 15;310:60-65. doi: 10.1016/j.jneuroim.2017.06.010. Epub 2017 Jun 27.
1696 miR-29c regulates NAV3 protein expression in a transgenic mouse model of Alzheimer's disease.Brain Res. 2015 Oct 22;1624:95-102. doi: 10.1016/j.brainres.2015.07.022. Epub 2015 Jul 23.
1697 Investigations into geriatric psychiatry challenges: AAGP Senior Investigator Award 2000.Am J Geriatr Psychiatry. 2000 Fall;8(4):276-83.
1698 Real-Time Detection of Spatial Disorientation in Persons with Mild Cognitive Impairment and Dementia.Gerontology. 2020;66(1):85-94. doi: 10.1159/000500971. Epub 2019 Jul 30.
1699 Characterization of neurocalcin delta membrane binding by biophysical methods.Colloids Surf B Biointerfaces. 2019 Feb 1;174:291-299. doi: 10.1016/j.colsurfb.2018.11.017. Epub 2018 Nov 12.
1700 A-dependent reduction of NCAM2-mediated synaptic adhesion contributes to synapse loss in Alzheimer's disease.Nat Commun. 2015 Nov 27;6:8836. doi: 10.1038/ncomms9836.
1701 Non-SMC condensin I complex, subunit D2 gene polymorphisms are associated with Parkinson's disease: a Han Chinese study.Genome. 2014 May;57(5):253-7. doi: 10.1139/gen-2014-0032. Epub 2014 Aug 11.
1702 Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: findings in Swedish twins.Am J Med Genet. 2001 Dec 8;105(8):724-8. doi: 10.1002/ajmg.1608.
1703 Frontotemporal dementia and mitochondrial DNA transitions.Neurobiol Dis. 2004 Mar;15(2):306-11. doi: 10.1016/j.nbd.2003.11.004.
1704 Investigations on the point mutations at nt 5460 of the mtDNA in different neurodegenerative and neuromuscular diseases.Eur Neurol. 1996;36(3):149-53. doi: 10.1159/000117233.
1705 SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.Aging Cell. 2018 Feb;17(1):e12679. doi: 10.1111/acel.12679. Epub 2017 Nov 11.
1706 Profile of neuronal exosomes in HIV cognitive impairment exposes sex differences.AIDS. 2019 Sep 1;33(11):1683-1692. doi: 10.1097/QAD.0000000000002272.
1707 Lower Expression of Ndfip1 Is Associated With Alzheimer Disease Pathogenesis Through Decreasing DMT1 Degradation and Increasing Iron Influx.Front Aging Neurosci. 2018 Jun 8;10:165. doi: 10.3389/fnagi.2018.00165. eCollection 2018.
1708 l-Dopa and dopamine conjugated naphthalenediimides modulate amyloid toxicity.Org Biomol Chem. 2018 Nov 7;16(41):7682-7692. doi: 10.1039/c8ob01691g. Epub 2018 Oct 4.
1709 Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.PLoS One. 2014 Apr 22;9(4):e95413. doi: 10.1371/journal.pone.0095413. eCollection 2014.
1710 Association of gene expression and methylation of UQCRC1 to the predisposition of Alzheimer's disease in a Chinese population.J Psychiatr Res. 2016 May;76:143-7. doi: 10.1016/j.jpsychires.2016.02.010. Epub 2016 Feb 18.
1711 Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease.Mol Brain. 2019 Jan 28;12(1):8. doi: 10.1186/s13041-019-0430-y.
1712 Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease.J Alzheimers Dis. 2014;39(2):347-55. doi: 10.3233/JAD-131499.
1713 Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish.Dev Dyn. 2008 Dec;237(12):3921-6. doi: 10.1002/dvdy.21806.
1714 Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein.J Biol Chem. 2008 Sep 26;283(39):26737-47. doi: 10.1074/jbc.M801633200. Epub 2008 Jul 17.
1715 Cytoskeleton derangement in brain of patients with Down syndrome, Alzheimer's disease and Pick's disease.J Neural Transm Suppl. 2003;(67):149-58. doi: 10.1007/978-3-7091-6721-2_13.
1716 Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid- secretion via deregulated lysosomal exocytosis.Nat Commun. 2013;4:2734. doi: 10.1038/ncomms3734.
1717 Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.Sci Rep. 2015 Sep 23;5:14324. doi: 10.1038/srep14324.
1718 Differential Roles of Environmental Enrichment in Alzheimer's Type of Neurodegeneration and Physiological Aging.Front Aging Neurosci. 2017 Jul 26;9:245. doi: 10.3389/fnagi.2017.00245. eCollection 2017.
1719 NFATc2 Modulates Microglial Activation in the APP/PS1 Mouse Model of Alzheimer's Disease.J Alzheimers Dis. 2017;58(3):775-787. doi: 10.3233/JAD-151203.
1720 Ca(2+), Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases.Front Aging Neurosci. 2018 Jul 9;10:199. doi: 10.3389/fnagi.2018.00199. eCollection 2018.
1721 Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.J Neurosci. 2010 Feb 17;30(7):2636-49. doi: 10.1523/JNEUROSCI.4456-09.2010.
1722 Brain in situ hybridization maps as a source for reverse-engineering transcriptional regulatory networks: Alzheimer's disease insights.Gene. 2016 Jul 15;586(1):77-86. doi: 10.1016/j.gene.2016.03.045. Epub 2016 Apr 3.
1723 Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.Mol Neurobiol. 2019 Mar;56(3):2101-2122. doi: 10.1007/s12035-018-1212-8. Epub 2018 Jul 10.
1724 Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens.Nat Genet. 2018 Dec;50(12):1716-1727. doi: 10.1038/s41588-018-0254-1. Epub 2018 Nov 5.
1725 Genetic polymorphisms of a novel vascular susceptibility gene, Ninjurin2 (NINJ2), are associated with a decreased risk of Alzheimer's disease.PLoS One. 2011;6(6):e20573. doi: 10.1371/journal.pone.0020573. Epub 2011 Jun 6.
1726 Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice.Pharm Biol. 2019 Dec;57(1):453-459. doi: 10.1080/13880209.2019.1629463.
1727 Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome.Biochem Biophys Res Commun. 2002 Aug 30;296(4):970-5. doi: 10.1016/s0006-291x(02)02035-1.
1728 NIR fluorescent probes with good water-solubility for detection of amyloid beta aggregates in Alzheimer's disease.J Mater Chem B. 2019 Sep 18;7(36):5535-5540. doi: 10.1039/c9tb01012b.
1729 Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.Lancet Neurol. 2011 Sep;10(9):785-96. doi: 10.1016/S1474-4422(11)70156-9. Epub 2011 Jul 27.
1730 The function of BMP4 during neurogenesis in the adult hippocampus in Alzheimer's disease.Ageing Res Rev. 2013 Jan;12(1):157-64. doi: 10.1016/j.arr.2012.05.002. Epub 2012 Jun 12.
1731 Alzheimer disease detection from structural MR images using FCM based weighted probabilistic neural network.Brain Imaging Behav. 2019 Feb;13(1):87-110. doi: 10.1007/s11682-018-9831-2.
1732 Increased expression of p130 in Alzheimer disease.Neurochem Res. 2007 Apr-May;32(4-5):639-44. doi: 10.1007/s11064-006-9146-3. Epub 2006 Sep 28.
1733 Association study of cholesterol-related genes in Alzheimer's disease.Neurogenetics. 2007 Aug;8(3):179-88. doi: 10.1007/s10048-007-0087-z. Epub 2007 Mar 27.
1734 Conformational analysis of apolipoprotein E3/E4 heteromerization.FEBS J. 2019 May;286(10):1986-1998. doi: 10.1111/febs.14794. Epub 2019 Mar 13.
1735 Expression of familial Alzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environment.Glia. 2016 Feb;64(2):317-29. doi: 10.1002/glia.22931. Epub 2015 Oct 14.
1736 Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAPP Release from PSEN1 Mutant iPSC-Derived Neurons.J Alzheimers Dis. 2019;72(3):885-899. doi: 10.3233/JAD-190602.
1737 Neuronal pentraxin 1: A synaptic-derived plasma biomarker in Alzheimer's disease.Neurobiol Dis. 2018 Jun;114:120-128. doi: 10.1016/j.nbd.2018.02.014. Epub 2018 Mar 6.
1738 RKIP-Mediated NF-B Signaling is involved in ELF-MF-mediated improvement in AD rat.Int J Med Sci. 2018 Nov 5;15(14):1658-1666. doi: 10.7150/ijms.28411. eCollection 2018.
1739 Magnetic resonance imaging of noradrenergic neurons.Brain Struct Funct. 2019 May;224(4):1609-1625. doi: 10.1007/s00429-019-01858-0. Epub 2019 Mar 22.
1740 Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4.
1741 NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.EMBO Mol Med. 2019 Apr;11(4):e9695. doi: 10.15252/emmm.201809695.
1742 Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases.Int J Mol Sci. 2016 Dec 13;17(12):2086. doi: 10.3390/ijms17122086.
1743 NRG3 gene is associated with the risk and age at onset of Alzheimer disease.J Neural Transm (Vienna). 2014 Feb;121(2):183-92. doi: 10.1007/s00702-013-1091-0. Epub 2013 Sep 24.
1744 The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in A generation.Neurobiol Aging. 2016 Nov;47:180-191. doi: 10.1016/j.neurobiolaging.2016.08.003. Epub 2016 Aug 12.
1745 Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.Alzheimers Res Ther. 2019 Mar 21;11(1):28. doi: 10.1186/s13195-019-0475-2.
1746 Association between presenilin-1 -48C/T polymorphism and Down's syndrome.Neurosci Lett. 2004 Aug 26;367(1):88-91. doi: 10.1016/j.neulet.2004.05.086.
1747 Potential roles of neurotensin on cognition in conditions of obese-insulin resistance.Neuropeptides. 2018 Dec;72:12-22. doi: 10.1016/j.npep.2018.09.002. Epub 2018 Sep 8.
1748 3-(Benzyloxy)-1-(5-[(18)F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain.Future Med Chem. 2017 Jun;9(10):983-994. doi: 10.4155/fmc-2017-0023. Epub 2017 Jun 20.
1749 Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients.Neurochem Res. 2011 Aug;36(8):1558-65. doi: 10.1007/s11064-011-0484-4. Epub 2011 May 3.
1750 Effects of Zn2+ binding on the structural and dynamic properties of amyloid peptide associated with Alzheimer's disease: Asp1 or Glu11?.ACS Chem Neurosci. 2013 Nov 20;4(11):1458-68. doi: 10.1021/cn4001445. Epub 2013 Sep 13.
1751 Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis.J Biol Chem. 2008 Sep 12;283(37):25492-25502. doi: 10.1074/jbc.M802072200. Epub 2008 Jul 2.
1752 Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease.Mol Neurobiol. 2019 Aug;56(8):5934-5949. doi: 10.1007/s12035-018-1466-1. Epub 2019 Jan 28.
1753 miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer's disease.Alzheimers Res Ther. 2016 May 24;8(1):20. doi: 10.1186/s13195-016-0186-x.
1754 A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers.Neurobiol Aging. 2007 Apr;28(4):519-23. doi: 10.1016/j.neurobiolaging.2006.02.011. Epub 2006 Apr 3.
1755 Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?.Neurosci Biobehav Rev. 2019 May;100:180-207. doi: 10.1016/j.neubiorev.2019.02.014. Epub 2019 Feb 25.
1756 OCIAD2 activates -secretase to enhance amyloid production by interacting with nicastrin.Cell Mol Life Sci. 2014 Jul;71(13):2561-76. doi: 10.1007/s00018-013-1515-x. Epub 2013 Nov 24.
1757 Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression.Brain. 2019 Apr 1;142(4):1077-1092. doi: 10.1093/brain/awz011.
1758 Structural Basis for Achieving GSK-3 Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery.J Med Chem. 2019 Nov 14;62(21):9600-9617. doi: 10.1021/acs.jmedchem.9b01030. Epub 2019 Oct 21.
1759 Chitosan nanofilm and electrospun nanofiber for quick drug release in the treatment of Alzheimer's disease: In vitro and in vivo evaluation.Int J Biol Macromol. 2017 Dec;105(Pt 1):131-142. doi: 10.1016/j.ijbiomac.2017.07.021. Epub 2017 Jul 8.
1760 Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Nov 27;62(22):10062-10097.
1761 Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease.J Alzheimers Dis. 2018;61(1):237-249. doi: 10.3233/JAD-170211.
1762 Molecular identification of AMY, an Alzheimer disease amyloid-associated protein.J Neuropathol Exp Neurol. 2003 Nov;62(11):1108-17. doi: 10.1093/jnen/62.11.1108.
1763 Understanding the interactions of different substrates with wild-type and mutant acylaminoacyl peptidase using molecular dynamics simulations.J Biomol Struct Dyn. 2018 Dec;36(16):4285-4302. doi: 10.1080/07391102.2017.1414634. Epub 2017 Dec 20.
1764 Amyloid- deposition and olfactory dysfunction in an Alzheimer's disease model.J Alzheimers Dis. 2013;37(4):699-712. doi: 10.3233/JAD-122443.
1765 A-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer's disease.Mol Neurodegener. 2015 Mar 19;10:13. doi: 10.1186/s13024-015-0007-x.
1766 CSF biomarkers -amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes.J Neurol Sci. 2017 Nov 15;382:91-95. doi: 10.1016/j.jns.2017.09.039. Epub 2017 Sep 28.
1767 Light-Induced Pupillary Responses in Alzheimer's Disease.Front Neurol. 2019 Apr 12;10:360. doi: 10.3389/fneur.2019.00360. eCollection 2019.
1768 Evaluation of the poly(ADP-ribose) polymerase-1 gene variants in Alzheimer's disease.J Clin Lab Anal. 2010;24(3):182-6. doi: 10.1002/jcla.20379.
1769 Identification of Alzheimer's Disease Autoantibodies and Their Target Biomarkers by Phage Microarrays.J Proteome Res. 2019 Jul 5;18(7):2940-2953. doi: 10.1021/acs.jproteome.9b00258. Epub 2019 Jun 7.
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1771 Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.J Neurosci. 2017 Mar 15;37(11):2878-2894. doi: 10.1523/JNEUROSCI.2534-16.2017. Epub 2017 Feb 13.
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1773 Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man.Brain Res. 1987 Sep;388(3):215-21. doi: 10.1016/0169-328x(87)90028-3.
1774 Hypothalamic vasopressin and oxytocin mRNA expression in relation to depressive state in Alzheimer's disease: a difference with major depressive disorder.J Neuroendocrinol. 2009 Aug;21(8):722-9. doi: 10.1111/j.1365-2826.2009.01890.x. Epub 2009 Jun 4.
1775 Older Adults With a Combination of Vision and Hearing Impairment Experience Higher Rates of Cognitive Impairment, Functional Dependence, and Worse Outcomes Across a Set of Quality Indicators.J Aging Health. 2019 Jan;31(1):85-108. doi: 10.1177/0898264317723407. Epub 2017 Aug 13.
1776 Prevention of oculopharyngeal muscular dystrophy by muscular expression of Llama single-chain intrabodies in vivo.Hum Mol Genet. 2009 May 15;18(10):1849-59. doi: 10.1093/hmg/ddp101. Epub 2009 Mar 3.
1777 Small Molecule Inhibition of Protein Disulfide Isomerase in Neuroblastoma Cells Induces an Oxidative Stress Response and Apoptosis Pathways.ACS Chem Neurosci. 2019 Sep 18;10(9):4068-4075. doi: 10.1021/acschemneuro.9b00301. Epub 2019 Aug 8.
1778 Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.J Neurosci Res. 2017 Jul;95(7):1503-1512. doi: 10.1002/jnr.23959. Epub 2016 Oct 5.
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1781 Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression.Front Mol Neurosci. 2019 Oct 15;12:242. doi: 10.3389/fnmol.2019.00242. eCollection 2019.
1782 Establishment of TUSMi008-A, an induced pluripotent stem cell (iPSC) line from a 76-year old Alzheimer's disease (AD) patient with PAXIP1 gene mutation.Stem Cell Res. 2019 Apr;36:101391. doi: 10.1016/j.scr.2019.101391. Epub 2019 Jan 26.
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1785 PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease.Neuroscience. 1998 Oct;86(4):1055-63. doi: 10.1016/s0306-4522(98)00130-4.
1786 A novel function for proSAAS as an amyloid anti-aggregant in Alzheimer's disease.J Neurochem. 2014 Feb;128(3):419-30. doi: 10.1111/jnc.12454. Epub 2013 Oct 24.
1787 The 2002 NIMH Provisional Diagnostic Criteria for Depression of Alzheimer's Disease (PDC-dAD): Gauging their Validity over a Decade Later.J Alzheimers Dis. 2017;58(2):449-462. doi: 10.3233/JAD-161061.
1788 MiR-21 attenuates apoptosis-triggered by amyloid- via modulating PDCD4/ PI3K/AKT/GSK-3 pathway in SH-SY5Y cells.Biomed Pharmacother. 2018 May;101:1003-1007. doi: 10.1016/j.biopha.2018.02.043. Epub 2018 Mar 22.
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1790 Decreased levels of PDI and P5 in oligodendrocytes in Alzheimer's disease.Neuropathology. 2017 Dec;37(6):495-501. doi: 10.1111/neup.12395. Epub 2017 Jul 21.
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1793 Dysregulation of dynorphins in Alzheimer disease.Neurobiol Aging. 2007 Nov;28(11):1700-8. doi: 10.1016/j.neurobiolaging.2006.07.002. Epub 2006 Aug 17.
1794 PIN-1 promoter polymorphisms in mild cognitive impairment and susceptibility to Alzheimer's disease: a preliminary report.Aging Clin Exp Res. 2007 Oct;19(5):406-9. doi: 10.1007/BF03324722.
1795 Relating constructs of attention and working memory to social withdrawal in Alzheimer's disease and schizophrenia: issues regarding paradigm selection.Neurosci Biobehav Rev. 2019 Feb;97:47-69. doi: 10.1016/j.neubiorev.2018.09.025. Epub 2018 Nov 3.
1796 Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.J Neurosci. 2008 May 7;28(19):5007-17. doi: 10.1523/JNEUROSCI.0590-08.2008.
1797 Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus.Neurosci Lett. 2019 Nov 1;712:134484. doi: 10.1016/j.neulet.2019.134484. Epub 2019 Sep 7.
1798 ABCB1 genotype and CSF beta-amyloid in Alzheimer disease.J Geriatr Psychiatry Neurol. 2011 Jun;24(2):63-6. doi: 10.1177/0891988711402325. Epub 2011 Apr 8.
1799 SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infection.PLoS Pathog. 2013;9(11):e1003775. doi: 10.1371/journal.ppat.1003775. Epub 2013 Nov 21.
1800 Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes.ACS Chem Neurosci. 2019 Aug 21;10(8):3510-3520. doi: 10.1021/acschemneuro.9b00123. Epub 2019 Jul 8.
1801 Genetic Analysis of PICK1 Gene in Alzheimer's Disease: A Study for Finding a New Gene Target.Front Neurol. 2019 Jan 9;9:1169. doi: 10.3389/fneur.2018.01169. eCollection 2018.
1802 Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.Front Aging Neurosci. 2018 Oct 22;10:332. doi: 10.3389/fnagi.2018.00332. eCollection 2018.
1803 Insight into the structural stability of wild-type and histidine mutants in Pin1 by experimental and computational methods.Sci Rep. 2019 Jun 10;9(1):8413. doi: 10.1038/s41598-019-44926-5.
1804 Hippocampal Proteomic Alteration in Triple Transgenic Mouse Model of Alzheimer's Disease and Implication of PINK 1 Regulation in Donepezil Treatment.J Proteome Res. 2019 Apr 5;18(4):1542-1552. doi: 10.1021/acs.jproteome.8b00818. Epub 2018 Dec 7.
1805 Incidence of dementia in relation to genetic variants at PITX2, ZFHX3, and ApoE 4 in atrial fibrillation patients.Pacing Clin Electrophysiol. 2015 Feb;38(2):171-7. doi: 10.1111/pace.12537. Epub 2014 Dec 12.
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1807 Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress Decreases the Insulin-Degrading Enzyme.PLoS One. 2015 Dec 4;10(12):e0143518. doi: 10.1371/journal.pone.0143518. eCollection 2015.
1808 Association study of interferon-, cytosolic phospholipase A2, and cyclooxygenase-2 gene polymorphisms in Alzheimer disease.Am J Geriatr Psychiatry. 2010 Nov;18(11):983-7. doi: 10.1097/JGP.0b013e3181e70c05.
1809 Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.Alzheimers Res Ther. 2019 Feb 2;11(1):16. doi: 10.1186/s13195-019-0469-0.
1810 APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.Am J Hum Genet. 1991 Sep;49(3):511-7.
1811 PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing.Nat Immunol. 2018 Sep;19(9):942-953. doi: 10.1038/s41590-018-0179-y. Epub 2018 Aug 13.
1812 Impact of working situation on mental and physical health for informal caregivers of older people with Alzheimer's disease in Italy. Results from the UP-TECH longitudinal study.Aging Ment Health. 2021 Jan;25(1):22-31. doi: 10.1080/13607863.2019.1667295. Epub 2019 Sep 23.
1813 Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease.Mol Neurodegener. 2017 Nov 6;12(1):82. doi: 10.1186/s13024-017-0219-3.
1814 Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.Ophthalmology. 2019 Apr;126(4):497-510. doi: 10.1016/j.ophtha.2018.08.009. Epub 2018 Aug 13.
1815 White matter architecture in major depression with anxious distress symptoms.Prog Neuropsychopharmacol Biol Psychiatry. 2019 Aug 30;94:109664. doi: 10.1016/j.pnpbp.2019.109664. Epub 2019 May 31.
1816 Common Variants in PLXNA4 and Correlation to CSF-related Phenotypes in Alzheimer's Disease.Front Neurosci. 2018 Dec 18;12:946. doi: 10.3389/fnins.2018.00946. eCollection 2018.
1817 Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia.Ann Neurol. 2018 Jul;84(1):78-88. doi: 10.1002/ana.25266. Epub 2018 Jul 3.
1818 POLD1 deficiency is involved in cognitive function impairment in AD patients and SAMP8 mice.Biomed Pharmacother. 2019 Jun;114:108833. doi: 10.1016/j.biopha.2019.108833. Epub 2019 Apr 9.
1819 Interactions between the products of the Herpes simplex genome and Alzheimer's disease susceptibility genes: relevance to pathological-signalling cascades.Neurochem Int. 2008 May;52(6):920-34. doi: 10.1016/j.neuint.2007.11.003. Epub 2007 Nov 23.
1820 Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity.Elife. 2019 Apr 11;8:e44425. doi: 10.7554/eLife.44425.
1821 Therapeutic Effects of Transplantation of As-MiR-937-Expressing Mesenchymal Stem Cells in Murine Model of Alzheimer's Disease.Cell Physiol Biochem. 2015;37(1):321-30. doi: 10.1159/000430356. Epub 2015 Aug 24.
1822 Protective effects of melatonin on mitochondrial biogenesis and mitochondrial structure and function in the HEK293-APPswe cell model of Alzheimer's disease.Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3542-3550. doi: 10.26355/eurrev_201904_17723.
1823 Explorative results from multistep screening for potential genetic risk loci of Alzheimer's disease in the longitudinal VITA study cohort.J Neural Transm (Vienna). 2018 Jan;125(1):77-87. doi: 10.1007/s00702-017-1796-6. Epub 2017 Oct 12.
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1825 The anteroposterior and primary-to-posterior limbic ratios as MRI-derived volumetric markers of Alzheimer's disease.J Neurol Sci. 2017 Jul 15;378:110-119. doi: 10.1016/j.jns.2017.04.046. Epub 2017 Apr 27.
1826 Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease.Neurochem Res. 2002 Oct;27(10):1035-48. doi: 10.1023/a:1020952704398.
1827 Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer's Disease.J Alzheimers Dis. 2018;62(4):1549-1565. doi: 10.3233/JAD-170988.
1828 Identification of Electrophysiological Changes in Alzheimer's Disease: A Microarray Based Transcriptomics and Molecular Pathway Analysis Study.CNS Neurol Disord Drug Targets. 2017;16(9):1027-1038. doi: 10.2174/1871527316666171023153837.
1829 Tyrosol Reduces Amyloid- Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice.J Alzheimers Dis. 2019;70(3):937-952. doi: 10.3233/JAD-190098.
1830 Association of PPP2R1A with Alzheimer's disease and specific cognitive domains.Neurobiol Aging. 2019 Sep;81:234-243. doi: 10.1016/j.neurobiolaging.2019.06.008. Epub 2019 Jul 2.
1831 Association between CAG repeat length in the PPP2R2B gene and Alzheimer disease in the Japanese population.Neurosci Lett. 2011 Jan 10;487(3):354-7. doi: 10.1016/j.neulet.2010.10.055. Epub 2010 Oct 26.
1832 Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease.Mol Cell Neurosci. 2017 Sep;83:83-91. doi: 10.1016/j.mcn.2017.07.002. Epub 2017 Jul 15.
1833 CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-B and p38 MAPK pathways in microglia.Eur J Pharmacol. 2018 Jan 15;819:190-197. doi: 10.1016/j.ejphar.2017.12.008. Epub 2017 Dec 6.
1834 A variant in PPP4R3A protects against alzheimer-related metabolic decline.Ann Neurol. 2017 Dec;82(6):900-911. doi: 10.1002/ana.25094. Epub 2017 Dec 4.
1835 The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.Mol Psychiatry. 2018 Oct;23(10):2090-2110. doi: 10.1038/s41380-018-0253-8. Epub 2018 Oct 3.
1836 Inheritance pattern of platelet membrane fluidity in Alzheimer disease.Am J Hum Genet. 1989 Jun;44(6):799-805.
1837 Oxidative Stress and Decreased Mitochondrial Superoxide Dismutase 2 and Peroxiredoxins 1 and 4 Based Mechanism of Concurrent Activation of AMPK and mTOR in Alzheimer's Disease.Curr Alzheimer Res. 2018;15(8):764-776. doi: 10.2174/1567205015666180223093020.
1838 Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome.J Neural Transm Suppl. 2001;(61):223-35. doi: 10.1007/978-3-7091-6262-0_18.
1839 Effective litmus gene test for monitoring the quality of blood samples: Application to Alzheimer's disease diagnostics.Sci Rep. 2017 Dec 4;7(1):16848. doi: 10.1038/s41598-017-17293-2.
1840 Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients.J Alzheimers Dis. 2016 May 30;53(3):831-41. doi: 10.3233/JAD-160220.
1841 Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer's disease patients.Metab Brain Dis. 2020 Jan;35(1):201-213. doi: 10.1007/s11011-019-00497-y. Epub 2019 Dec 13.
1842 Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.J Neurol. 2014 Nov;261(11):2085-92. doi: 10.1007/s00415-014-7456-y. Epub 2014 Aug 10.
1843 Parkin Overexpression Ameliorates PrP106-126-Induced Neurotoxicity via Enhanced Autophagy in N2a Cells.Cell Mol Neurobiol. 2017 May;37(4):717-728. doi: 10.1007/s10571-016-0407-7. Epub 2016 Jul 18.
1844 The PKR activator PACT is induced by A: involvement in Alzheimer's disease.Brain Pathol. 2012 Mar;22(2):219-29. doi: 10.1111/j.1750-3639.2011.00520.x. Epub 2011 Sep 16.
1845 Lipidized Prolactin-Releasing Peptide Agonist Attenuates Hypothermia-Induced Tau Hyperphosphorylation in Neurons.J Alzheimers Dis. 2019;67(4):1187-1200. doi: 10.3233/JAD-180837.
1846 APOE 4 Carriers Show Delayed Recovery of Verbal Memory and Smaller Entorhinal Volume in the First Year After Ischemic Stroke.J Alzheimers Dis. 2019;71(1):245-259. doi: 10.3233/JAD-190566.
1847 PRND 3'UTR polymorphism may be associated with behavioral disturbances in Alzheimer disease.Prion. 2012 Jan-Mar;6(1):73-80. doi: 10.4161/pri.6.1.18428.
1848 Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology.Cells. 2019 Nov 13;8(11):1430. doi: 10.3390/cells8111430.
1849 CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease.Alzheimers Res Ther. 2016 Apr 19;8(1):15. doi: 10.1186/s13195-016-0183-0.
1850 Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease.Exp Mol Med. 2019 Nov 15;51(11):1-17. doi: 10.1038/s12276-019-0326-z.
1851 PrP-grafted antibodies bind certain amyloid -protein aggregates, but do not prevent toxicity.Brain Res. 2019 May 1;1710:125-135. doi: 10.1016/j.brainres.2018.12.038. Epub 2018 Dec 26.
1852 Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of A-induced impaired axonal transport.Mol Neurodegener. 2017 Feb 28;12(1):23. doi: 10.1186/s13024-017-0164-1.
1853 Increase in expression levels and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in amyloid beta-resistant nerve cells.J Biol Chem. 2007 Oct 19;282(42):30523-34. doi: 10.1074/jbc.M700869200. Epub 2007 Aug 29.
1854 A point-based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease.Alzheimers Dement. 2014 Nov;10(6):646-55. doi: 10.1016/j.jalz.2013.12.014. Epub 2014 Feb 1.
1855 A comprehensive analysis on preservation patterns of gene co-expression networks during Alzheimer's disease progression.BMC Bioinformatics. 2017 Dec 20;18(1):579. doi: 10.1186/s12859-017-1946-8.
1856 Novel prodrug PRX-P4-003, selectively activated by gut enzymes, may reduce the risk of iatrogenic addiction and abuse.Drug Alcohol Depend. 2018 May 1;186:159-166. doi: 10.1016/j.drugalcdep.2017.12.042. Epub 2018 Mar 2.
1857 Effect of intraperitoneal or intracerebroventricular injection of streptozotocin on learning and memory in mice.Exp Ther Med. 2018 Sep;16(3):2375-2380. doi: 10.3892/etm.2018.6487. Epub 2018 Jul 19.
1858 Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease.Mol Neurobiol. 2019 Sep;56(9):6017-6034. doi: 10.1007/s12035-019-1479-4. Epub 2019 Feb 1.
1859 Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model.J Alzheimers Dis. 2011;24(2):349-61. doi: 10.3233/JAD-2011-101797.
1860 PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease.J Neurosci. 2019 Jun 12;39(24):4636-4656. doi: 10.1523/JNEUROSCI.0116-19.2019. Epub 2019 Apr 4.
1861 Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease.J Autoimmun. 2012 Jun;38(4):369-80. doi: 10.1016/j.jaut.2012.03.004. Epub 2012 May 2.
1862 Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a.Nat Commun. 2018 Jul 20;9(1):2865. doi: 10.1038/s41467-018-05209-1.
1863 What electrophysiology tells us about Alzheimer's disease: a window into the synchronization and connectivity of brain neurons.Neurobiol Aging. 2020 Jan;85:58-73. doi: 10.1016/j.neurobiolaging.2019.09.008. Epub 2019 Sep 19.
1864 X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.J Med Chem. 2017 Nov 22;60(22):9299-9319. doi: 10.1021/acs.jmedchem.7b01292. Epub 2017 Nov 8.
1865 Negative regulation of AbetaPP gene expression by pur-alpha.J Alzheimers Dis. 2008 Sep;15(1):71-82. doi: 10.3233/jad-2008-15106.
1866 Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease.Mol Psychiatry. 2020 Dec;25(12):3380-3398. doi: 10.1038/s41380-019-0483-4. Epub 2019 Aug 20.
1867 Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103.Sci Rep. 2015 Jul 30;5:12584. doi: 10.1038/srep12584.
1868 RAB10: an Alzheimer's disease resilience locus and potential drug target.Clin Interv Aging. 2018 Dec 28;14:73-79. doi: 10.2147/CIA.S159148. eCollection 2019.
1869 A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of -amyloid production.Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005.
1870 Rab21, a Novel PS1 Interactor, Regulates -Secretase Activity via PS1 Subcellular Distribution.Mol Neurobiol. 2018 May;55(5):3841-3855. doi: 10.1007/s12035-017-0606-3. Epub 2017 May 25.
1871 Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.J Chem Neuroanat. 2011 Oct;42(2):102-10. doi: 10.1016/j.jchemneu.2011.05.012. Epub 2011 Jun 12.
1872 Targeted Quantitative Proteomic Approach for High-Throughput Quantitative Profiling of Small GTPases in Brain Tissues of Alzheimer's Disease Patients.Anal Chem. 2019 Oct 1;91(19):12307-12314. doi: 10.1021/acs.analchem.9b02485. Epub 2019 Sep 10.
1873 Application of Weighted Gene Co-Expression Network Analysis to Explore the Key Genes in Alzheimer's Disease.J Alzheimers Dis. 2018;65(4):1353-1364. doi: 10.3233/JAD-180400.
1874 Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease.Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):243-50. doi: 10.1159/000051266.
1875 App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.J Neurosci. 2003 Jul 30;23(17):6788-92. doi: 10.1523/JNEUROSCI.23-17-06788.2003.
1876 Role of Rab GTPases in Alzheimer's Disease.ACS Chem Neurosci. 2019 Feb 20;10(2):828-838. doi: 10.1021/acschemneuro.8b00387. Epub 2018 Oct 11.
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1878 Modifying Rap1-signalling by targeting Pde6 is neuroprotective in models of Alzheimer's disease.Mol Neurodegener. 2018 Sep 26;13(1):50. doi: 10.1186/s13024-018-0283-3.
1879 The enhancement of amyloid precursor protein and beta-site amyloid cleavage enzyme 1 interaction: amyloid-beta production with aging.Int J Mol Med. 2010 Mar;25(3):401-7. doi: 10.3892/ijmm_00000358.
1880 The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair.Neurobiol Dis. 2006 Sep;23(3):708-16. doi: 10.1016/j.nbd.2006.06.005. Epub 2006 Jul 24.
1881 RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.J Biol Chem. 2018 Jan 26;293(4):1353-1362. doi: 10.1074/jbc.M117.808402. Epub 2017 Dec 7.
1882 Adrenomedullin Expression in Alzheimer's Brain.Curr Alzheimer Res. 2016;13(4):428-38. doi: 10.2174/1567205013666160229112725.
1883 Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.PLoS One. 2013;8(1):e53349. doi: 10.1371/journal.pone.0053349. Epub 2013 Jan 8.
1884 Chemerin-9 Peptide Enhances Memory and Ameliorates A(1-42)-Induced Object Memory Impairment in Mice.Biol Pharm Bull. 2020 Feb 1;43(2):272-283. doi: 10.1248/bpb.b19-00510. Epub 2019 Nov 19.
1885 Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease.Nat Commun. 2017 Oct 13;8(1):909. doi: 10.1038/s41467-017-00867-z.
1886 Cold Shock Induced Protein RBM3 but Not Mild Hypothermia Protects Human SH-SY5Y Neuroblastoma Cells From MPP(+)-Induced Neurotoxicity.Front Neurosci. 2018 May 3;12:298. doi: 10.3389/fnins.2018.00298. eCollection 2018.
1887 Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study.PLoS Med. 2017 Mar 28;14(3):e1002272. doi: 10.1371/journal.pmed.1002272. eCollection 2017 Mar.
1888 Regulator of calcineurin 1 is a novel RNA-binding protein to regulate neuronal apoptosis.Mol Psychiatry. 2021 Apr;26(4):1361-1375. doi: 10.1038/s41380-019-0487-0. Epub 2019 Aug 27.
1889 MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms.PLoS One. 2013;8(1):e54222. doi: 10.1371/journal.pone.0054222. Epub 2013 Jan 17.
1890 Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimer's disease and schizophrenia: Insights from studies in patient populations and animal models.Neurosci Biobehav Rev. 2019 Feb;97:112-137. doi: 10.1016/j.neubiorev.2018.09.027. Epub 2018 Oct 9.
1891 The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PLoS One. 2017 Sep 6;12(9):e0184262. doi: 10.1371/journal.pone.0184262. eCollection 2017.
1892 Selection for depression-specific dementia cases with replication in two cohorts.PLoS One. 2019 May 31;14(5):e0216413. doi: 10.1371/journal.pone.0216413. eCollection 2019.
1893 Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia.Am J Alzheimers Dis Other Demen. 2014 Feb;29(1):38-44. doi: 10.1177/1533317513505131.
1894 Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.Cell Transplant. 2017 Apr 13;26(4):693-702. doi: 10.3727/096368916X694184. Epub 2016 Nov 30.
1895 Regucalcin confers resistance to amyloid- toxicity in neuronally differentiated PC12 cells.FEBS Open Bio. 2018 Jan 20;8(3):349-360. doi: 10.1002/2211-5463.12374. eCollection 2018 Mar.
1896 Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4.J Biol Chem. 2016 Oct 14;291(42):21903-21912. doi: 10.1074/jbc.M116.753582. Epub 2016 Aug 25.
1897 Effect of site-specific amino acid D-isomerization on -sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides.Biochem Biophys Res Commun. 2019 Jan 1;508(1):184-190. doi: 10.1016/j.bbrc.2018.11.043. Epub 2018 Nov 22.
1898 Increase of zinc finger protein 179 in response to CCAAT/enhancer binding protein delta conferring an antiapoptotic effect in astrocytes of Alzheimer's disease.Mol Neurobiol. 2015 Feb;51(1):370-82. doi: 10.1007/s12035-014-8714-9. Epub 2014 May 1.
1899 The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease.Eur J Neurosci. 2005 Mar;21(5):1289-98. doi: 10.1111/j.1460-9568.2005.03977.x.
1900 Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis.Neurology. 2018 Feb 27;90(9):e754-e762. doi: 10.1212/WNL.0000000000005030. Epub 2018 Jan 31.
1901 Housekeepers for accurate transcript expression analysis in Alzheimer's disease autopsy brain tissue.Alzheimers Dement. 2010 Nov;6(6):465-74. doi: 10.1016/j.jalz.2009.11.002.
1902 Studying the Specific Activity of the Amide Form of HLDF-6 Peptide using the Transgenic Model of Alzheimer's Disease.Acta Naturae. 2017 Jul-Sep;9(3):64-70.
1903 The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.Hum Mol Genet. 2010 Oct 1;19(19):3835-43. doi: 10.1093/hmg/ddq302. Epub 2010 Jul 22.
1904 A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.Am J Hum Genet. 2006 Jan;78(1):78-88. doi: 10.1086/498851. Epub 2005 Nov 15.
1905 Tau drives translational selectivity by interacting with ribosomal proteins.Acta Neuropathol. 2019 Apr;137(4):571-583. doi: 10.1007/s00401-019-01970-9. Epub 2019 Feb 13.
1906 Distinct [(18)F]THK5351 binding patterns in primary progressive aphasia variants.Eur J Nucl Med Mol Imaging. 2018 Dec;45(13):2342-2357. doi: 10.1007/s00259-018-4075-3. Epub 2018 Jun 26.
1907 DHA Selectively Protects SAMP-8-Associated Cognitive Deficits Through Inhibition of JNK.Mol Neurobiol. 2019 Mar;56(3):1618-1627. doi: 10.1007/s12035-018-1185-7. Epub 2018 Jun 17.
1908 N-Acetylcysteine Prevents the Spatial Memory Deficits and the Redox-Dependent RyR2 Decrease Displayed by an Alzheimer's Disease Rat Model.Front Aging Neurosci. 2018 Dec 6;10:399. doi: 10.3389/fnagi.2018.00399. eCollection 2018.
1909 Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer's Disease.Am J Hypertens. 2018 Jun 11;31(7):818-826. doi: 10.1093/ajh/hpy046.
1910 Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.PLoS One. 2017 Jul 14;12(7):e0181486. doi: 10.1371/journal.pone.0181486. eCollection 2017.
1911 Functional segregation of executive control network and frontoparietal network in Alzheimer's disease.Cortex. 2019 Nov;120:36-48. doi: 10.1016/j.cortex.2019.04.026. Epub 2019 May 18.
1912 Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families.Neurobiol Aging. 2011 Feb;32(2):249-56. doi: 10.1016/j.neurobiolaging.2009.02.014. Epub 2009 Mar 27.
1913 Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia.J Formos Med Assoc. 2016 Jan;115(1):38-44. doi: 10.1016/j.jfma.2015.01.008. Epub 2015 Feb 19.
1914 The roles of S-nitrosylation and S-glutathionylation in Alzheimer's disease.Methods Enzymol. 2019;626:499-538. doi: 10.1016/bs.mie.2019.08.004.
1915 Decreased expression of suprabasin induces aberrant differentiation and apoptosis of epidermal keratinocytes: Possible role for atopic dermatitis.J Dermatol Sci. 2019 Sep;95(3):107-112. doi: 10.1016/j.jdermsci.2019.07.009. Epub 2019 Jul 27.
1916 Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.Am J Geriatr Psychiatry. 2005 Dec;13(12):1041-51. doi: 10.1176/appi.ajgp.13.12.1041.
1917 Contribution of syndecans to cellular internalization and fibrillation of amyloid-(1-42).Sci Rep. 2019 Feb 4;9(1):1393. doi: 10.1038/s41598-018-37476-9.
1918 Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.ASN Neuro. 2015 Dec 23;7(6):1759091415618916. doi: 10.1177/1759091415618916. Print 2015 Nov-Dec.
1919 Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer's Disease.J Alzheimers Dis. 2019;72(4):1059-1075. doi: 10.3233/JAD-190475.
1920 A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians.Mol Carcinog. 2012 May;51(5):433-8. doi: 10.1002/mc.20808. Epub 2011 Jun 7.
1921 Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease.Neurochem Res. 2005 Aug;30(8):1009-19. doi: 10.1007/s11064-005-6787-6.
1922 Selenoprotein P and its potential role in Alzheimer's disease.Hormones (Athens). 2020 Mar;19(1):73-79. doi: 10.1007/s42000-019-00112-w. Epub 2019 Jun 27.
1923 Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.J Alzheimers Dis. 2017;55(2):749-762. doi: 10.3233/JAD-151208.
1924 Detecting genetic association through shortest paths in a bidirected graph.Genet Epidemiol. 2017 Sep;41(6):481-497. doi: 10.1002/gepi.22051. Epub 2017 Jun 19.
1925 Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer's Disease.Int J Mol Sci. 2019 Feb 13;20(4):803. doi: 10.3390/ijms20040803.
1926 Identification of septins in neurofibrillary tangles in Alzheimer's disease.Am J Pathol. 1998 Nov;153(5):1551-60. doi: 10.1016/S0002-9440(10)65743-4.
1927 SEPT8 modulates -amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr 15.
1928 PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis.Neurobiol Aging. 2017 Jul;55:99-114. doi: 10.1016/j.neurobiolaging.2017.03.016. Epub 2017 Mar 31.
1929 Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease.Proc Natl Acad Sci U S A. 1989 Nov;86(21):8284-8. doi: 10.1073/pnas.86.21.8284.
1930 Association studies between the plasmin genes and late-onset Alzheimer's disease.Neurobiol Aging. 2007 Jul;28(7):1041-3. doi: 10.1016/j.neurobiolaging.2006.05.028. Epub 2006 Jul 7.
1931 Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.J Biol Chem. 2006 Sep 29;281(39):29268-77. doi: 10.1074/jbc.M600690200. Epub 2006 Jul 17.
1932 Shared Molecular Signatures Across Neurodegenerative Diseases and Herpes Virus Infections Highlights Potential Mechanisms for Maladaptive Innate Immune Responses.Sci Rep. 2019 Jun 19;9(1):8795. doi: 10.1038/s41598-019-45129-8.
1933 Association of genetic variants in senataxin and Alzheimer's disease in a Chinese Han population in Taiwan.Chin J Physiol. 2014 Apr 30;57(2):83-9. doi: 10.4077/CJP.2014.BAC228.
1934 Exome sequencing in an Italian family with Alzheimer's disease points to a role for seizure-related gene 6 (SEZ6) rare variant R615H.Alzheimers Res Ther. 2018 Oct 12;10(1):106. doi: 10.1186/s13195-018-0435-2.
1935 Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.CNS Drugs. 2018 Sep;32(9):849-861. doi: 10.1007/s40263-018-0554-0.
1936 BRICHOS domain associated with lung fibrosis, dementia and cancer--a chaperone that prevents amyloid fibril formation?.FEBS J. 2011 Oct;278(20):3893-904. doi: 10.1111/j.1742-4658.2011.08209.x. Epub 2011 Jul 5.
1937 Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1.Exp Neurol. 2019 Jan;311:67-79. doi: 10.1016/j.expneurol.2018.09.012. Epub 2018 Sep 20.
1938 The Protective Effects of PSM-04 Against Beta Amyloid-Induced Neurotoxicity in Primary Cortical Neurons and an Animal Model of Alzheimer's Disease.Front Pharmacol. 2019 Jan 24;10:2. doi: 10.3389/fphar.2019.00002. eCollection 2019.
1939 Up-regulation of NSP3 by Oligomeric A Accelerates Neuronal Death Through Cas-independent Rap1A Activation.Neuroscience. 2018 Aug 21;386:182-193. doi: 10.1016/j.neuroscience.2018.06.035. Epub 2018 Jun 30.
1940 Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.FEBS J. 2010 Jul;277(14):3051-67. doi: 10.1111/j.1742-4658.2010.07719.x. Epub 2010 Jun 22.
1941 Solution structures of the SH3 domains from Shank scaffold proteins and their interactions with Cav1.3 calcium channels.FEBS Lett. 2018 Aug;592(16):2786-2797. doi: 10.1002/1873-3468.13209. Epub 2018 Aug 12.
1942 Identification of Sidt2 as a lysosomal cation-conducting protein.FEBS Lett. 2017 Jan;591(1):76-87. doi: 10.1002/1873-3468.12528. Epub 2017 Jan 2.
1943 Ethanol Activation of PKA Mediates Single-Minded 2 Expression in Neuronal Cells.Mol Neurobiol. 2015 Dec;52(3):1234-1244. doi: 10.1007/s12035-014-8924-1. Epub 2014 Oct 17.
1944 Intact global cognitive and olfactory ability predicts lack of transition to dementia.Alzheimers Dement. 2020 Feb;16(2):326-334. doi: 10.1016/j.jalz.2019.08.200. Epub 2020 Jan 4.
1945 Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles.Neurobiol Learn Mem. 2019 Dec;166:107082. doi: 10.1016/j.nlm.2019.107082. Epub 2019 Sep 5.
1946 microRNA-34a (miRNA-34a) Mediated Down-Regulation of the Post-synaptic Cytoskeletal Element SHANK3 in Sporadic Alzheimer's Disease (AD).Front Neurol. 2019 Feb 6;10:28. doi: 10.3389/fneur.2019.00028. eCollection 2019.
1947 Does plasma phoenixin level associate with cognition? Comparison between subjective memory complaint, mild cognitive impairment, and mild Alzheimer's disease.Int Psychogeriatr. 2017 May 29:1-8. doi: 10.1017/S1041610217000825. Online ahead of print.
1948 Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse.J Neurosci. 2016 Aug 17;36(33):8653-67. doi: 10.1523/JNEUROSCI.1429-16.2016.
1949 Parkin and synphilin-1 isoform expression changes in Lewy body diseases.Neurobiol Dis. 2007 Jun;26(3):681-7. doi: 10.1016/j.nbd.2007.03.007. Epub 2007 Mar 27.
1950 RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.J Biol Chem. 2018 Jul 13;293(28):11047-11066. doi: 10.1074/jbc.RA118.001747. Epub 2018 May 25.
1951 Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30.
1952 Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model.Neurobiol Aging. 2019 May;77:144-153. doi: 10.1016/j.neurobiolaging.2019.01.011. Epub 2019 Jan 25.
1953 Overexpression of SNX3 Decreases Amyloid- Peptide Production by Reducing Internalization of Amyloid Precursor Protein.Neurodegener Dis. 2018;18(1):26-37. doi: 10.1159/000486199. Epub 2018 Feb 7.
1954 SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates A Accumulation and Memory Deficits in an AD Mouse.Front Cell Neurosci. 2019 Sep 6;13:410. doi: 10.3389/fncel.2019.00410. eCollection 2019.
1955 Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining.PLoS One. 2016 Dec 22;11(12):e0168812. doi: 10.1371/journal.pone.0168812. eCollection 2016.
1956 Alzheimer's Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters.Neuropsychobiology. 2019;78(2):79-85. doi: 10.1159/000497164. Epub 2019 May 16.
1957 Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP).Transl Psychiatry. 2013 May 14;3(5):e256. doi: 10.1038/tp.2013.13.
1958 Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):508-16. doi: 10.1002/ajmg.b.30503.
1959 Early Impairments of Hippocampal Neurogenesis in 5xFAD Mouse Model of Alzheimer's Disease Are Associated with Altered Expression of SOXB Transcription Factors.J Alzheimers Dis. 2018;65(3):963-976. doi: 10.3233/JAD-180277.
1960 MicroRNA-129-5p alleviates nerve injury and inflammatory response of Alzheimer's disease via downregulating SOX6.Cell Cycle. 2019 Nov;18(22):3095-3110. doi: 10.1080/15384101.2019.1669388. Epub 2019 Sep 29.
1961 Modulation of SPARC/Hevin Proteins in Alzheimer's Disease Brain Injury.J Alzheimers Dis. 2019;68(2):695-710. doi: 10.3233/JAD-181032.
1962 Novel SPAST deletion and reduced DPY30 expression in a Spastic Paraplegia type 4 kindred.BMC Med Genet. 2014 Apr 1;15:39. doi: 10.1186/1471-2350-15-39.
1963 A Meta-Analysis of Alzheimer's Disease Brain Transcriptomic Data.J Alzheimers Dis. 2019;68(4):1635-1656. doi: 10.3233/JAD-181085.
1964 Tau pathology in the olfactory bulb correlates with Braak stage, Lewy body pathology and apolipoprotein epsilon4.Neuropathol Appl Neurobiol. 2003 Oct;29(5):503-10. doi: 10.1046/j.1365-2990.2003.00453.x.
1965 Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide.Glia. 2019 Mar;67(3):498-511. doi: 10.1002/glia.23558. Epub 2018 Nov 28.
1966 Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of -Secretase.J Neurosci. 2019 Oct 23;39(43):8600-8610. doi: 10.1523/JNEUROSCI.0838-19.2019. Epub 2019 Sep 16.
1967 BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease.Neurobiol Aging. 2014 Jul;35(7):1596-604. doi: 10.1016/j.neurobiolaging.2014.01.007. Epub 2014 Jan 13.
1968 The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.J Mol Neurosci. 2004;24(2):269-76. doi: 10.1385/JMN:24:2:269.
1969 A randomised double-blind placebo-controlled pilot trial of a combined extract of sage, rosemary and melissa, traditional herbal medicines, on the enhancement of memory in normal healthy subjects, including influence of age.Phytomedicine. 2018 Jan 15;39:42-48. doi: 10.1016/j.phymed.2017.08.015. Epub 2017 Aug 18.
1970 SRSF1 and PTBP1 Are trans-Acting Factors That Suppress the Formation of a CD33 Splicing Isoform Linked to Alzheimer's Disease Risk.Mol Cell Biol. 2019 Aug 27;39(18):e00568-18. doi: 10.1128/MCB.00568-18. Print 2019 Sep 15.
1971 CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility.Hum Mol Genet. 2014 May 15;23(10):2729-36. doi: 10.1093/hmg/ddt666. Epub 2013 Dec 30.
1972 Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease.J Neurochem. 2012 Oct;123(1):159-71. doi: 10.1111/j.1471-4159.2012.07873.x. Epub 2012 Aug 16.
1973 Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model.Mol Ther Nucleic Acids. 2019 Dec 6;18:681-695. doi: 10.1016/j.omtn.2019.10.002. Epub 2019 Oct 10.
1974 Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration.Brain. 2020 May 1;143(5):1332-1340. doi: 10.1093/brain/awz358.
1975 Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1a.ASN Neuro. 2013 May 30;5(2):141-8. doi: 10.1042/AN20130006.
1976 A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.Neurobiol Aging. 2016 Jan;37:208.e1-208.e9. doi: 10.1016/j.neurobiolaging.2015.09.009. Epub 2015 Sep 25.
1977 STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca(2+) entry.J Mol Med (Berl). 2018 Oct;96(10):1061-1079. doi: 10.1007/s00109-018-1677-y. Epub 2018 Aug 7.
1978 On the Role of Store-Operated Calcium Entry in Acute and Chronic Neurodegenerative Diseases.Front Mol Neurosci. 2018 Mar 22;11:87. doi: 10.3389/fnmol.2018.00087. eCollection 2018.
1979 Anti-neuroinflammatory effects of a food-grade phenolic-enriched maple syrup extract in a mouse model of Alzheimer's disease.Nutr Neurosci. 2021 Sep;24(9):710-719. doi: 10.1080/1028415X.2019.1672009. Epub 2019 Oct 4.
1980 The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases.Front Neurosci. 2017 May 16;11:254. doi: 10.3389/fnins.2017.00254. eCollection 2017.
1981 SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface.Hum Mol Genet. 2013 Dec 15;22(24):4888-900. doi: 10.1093/hmg/ddt339. Epub 2013 Jul 17.
1982 Targeting STOX1 in the therapy of preeclampsia.Expert Opin Ther Targets. 2016 Dec;20(12):1433-1443. doi: 10.1080/14728222.2016.1253682. Epub 2016 Nov 8.
1983 Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases.Nat Chem Biol. 2019 Aug;15(8):786-794. doi: 10.1038/s41589-019-0322-6. Epub 2019 Jul 18.
1984 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.J Neurosci Res. 2004 Mar 1;75(5):698-703. doi: 10.1002/jnr.20028.
1985 Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.Neuroscience. 2006;138(2):511-22. doi: 10.1016/j.neuroscience.2005.11.017. Epub 2006 Jan 18.
1986 SUCLG2 identified as both a determinator of CSF A1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.Hum Mol Genet. 2014 Dec 15;23(24):6644-58. doi: 10.1093/hmg/ddu372. Epub 2014 Jul 15.
1987 Polymorphisms of small ubiquitin-related modifier genes are associated with risk of Alzheimer's disease in Korean: A case-control study.J Neurol Sci. 2016 May 15;364:122-7. doi: 10.1016/j.jns.2016.03.023. Epub 2016 Mar 19.
1988 The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance.ACS Chem Neurosci. 2019 Sep 18;10(9):3927-3938. doi: 10.1021/acschemneuro.9b00351. Epub 2019 Aug 23.
1989 Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models.Behav Brain Res. 2017 Mar 30;322(Pt B):288-298. doi: 10.1016/j.bbr.2016.06.002. Epub 2016 Jun 2.
1990 Human Alzheimer's disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry.Amino Acids. 2011 Mar;40(3):765-79. doi: 10.1007/s00726-010-0645-9. Epub 2010 Jun 19.
1991 DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease.J Psychiatr Res. 2017 Sep;92:74-80. doi: 10.1016/j.jpsychires.2017.04.003. Epub 2017 Apr 11.
1992 Age-related changes in gene expression are accelerated in Alzheimer's disease.Synapse. 2011 Sep;65(9):971-4. doi: 10.1002/syn.20933. Epub 2011 Apr 11.
1993 Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Ann Neurol. 2019 Feb;85(2):259-271. doi: 10.1002/ana.25392. Epub 2019 Jan 7.
1994 Synaptopodin Deficiency Ameliorates Symptoms in the 3xTg Mouse Model of Alzheimer's Disease.J Neurosci. 2019 May 15;39(20):3983-3992. doi: 10.1523/JNEUROSCI.2920-18.2019. Epub 2019 Mar 14.
1995 Mitsugumin 29 is transcriptionally induced in senile plaque-associated astrocytes.Brain Res. 2012 Mar 2;1441:9-16. doi: 10.1016/j.brainres.2011.12.062. Epub 2012 Jan 12.
1996 TNFR-associated factor-2 (TRAF-2) in Alzheimer's disease.Neurobiol Aging. 2009 Jul;30(7):1052-60. doi: 10.1016/j.neurobiolaging.2007.10.014. Epub 2007 Dec 11.
1997 Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease.Neurogenetics. 2008 May;9(2):127-38. doi: 10.1007/s10048-008-0122-8. Epub 2008 Mar 14.
1998 Intranasal TAT-haFGF Improves Cognition and Amyloid- Pathology in an APP/PS1 Mouse Model of Alzheimer's Disease.J Alzheimers Dis. 2016;51(4):985-90. doi: 10.3233/JAD-151121.
1999 Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors.Cancer Res. 2002 Aug 1;62(15):4273-81.
2000 SCA17 repeat expansion: mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications.Clin Chim Acta. 2010 Mar;411(5-6):375-80. doi: 10.1016/j.cca.2009.12.002. Epub 2009 Dec 11.
2001 Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.Cell Mol Life Sci. 2019 Mar;76(5):1005-1025. doi: 10.1007/s00018-018-2998-2. Epub 2019 Jan 1.
2002 Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.J Neuropathol Exp Neurol. 1996 Aug;55(8):889-95. doi: 10.1097/00005072-199608000-00004.
2003 Association of the transcobalamin II gene 776C ?G polymorphism with Alzheimer's type dementia: dependence on the 5, 10-methylenetetrahydrofolate reductase 1298A ?C polymorphism genotype.Ann Clin Biochem. 2015 Jul;52(Pt 4):448-55. doi: 10.1177/0004563214561770. Epub 2014 Nov 13.
2004 Development of surface-engineered PLGA nanoparticulate-delivery system of Tet1-conjugated nattokinase enzyme for inhibition of A(40) plaques in Alzheimer's disease.Int J Nanomedicine. 2017 Dec 13;12:8749-8768. doi: 10.2147/IJN.S144545. eCollection 2017.
2005 Exploring the bi-directional relationship between autophagy and Alzheimer's disease.CNS Neurosci Ther. 2020 Feb;26(2):155-166. doi: 10.1111/cns.13216. Epub 2019 Sep 10.
2006 Differential regional and cellular distribution of TFF3 peptide in the human brain.Amino Acids. 2015 May;47(5):1053-63. doi: 10.1007/s00726-015-1938-9. Epub 2015 Feb 18.
2007 Protective Effect of Notoginsenoside R1 on an APP/PS1 Mouse Model of Alzheimer's Disease by Up-Regulating Insulin Degrading Enzyme and Inhibiting A Accumulation.CNS Neurol Disord Drug Targets. 2015;14(3):360-9. doi: 10.2174/1871527314666150225141521.
2008 MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2.Cancer Res. 2011 Jan 15;71(2):583-92. doi: 10.1158/0008-5472.CAN-10-2587. Epub 2011 Jan 11.
2009 Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid.Mol Cell Proteomics. 2019 Mar;18(3):546-560. doi: 10.1074/mcp.RA118.001290. Epub 2019 Jan 3.
2010 Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease [corrected].PLoS One. 2013 Jul 5;8(7):e68361. doi: 10.1371/journal.pone.0068361. Print 2013.
2011 Identification of Blood Biomarkers for Alzheimer's Disease Through Computational Prediction and Experimental Validation.Front Neurol. 2019 Jan 8;9:1158. doi: 10.3389/fneur.2018.01158. eCollection 2018.
2012 Evaluation of Matrix Metalloproteinase-2 (MMP-2) and -9 (MMP-9) and Their Tissue Inhibitors (TIMP-1 and TIMP-2) in Plasma from Patients with Neurodegenerative Dementia.J Alzheimers Dis. 2018;66(3):1265-1273. doi: 10.3233/JAD-180752.
2013 Ginsenoside Rg1 and Acori Graminei Rhizoma Attenuates Neuron Cell Apoptosis by Promoting the Expression of miR-873-5p in Alzheimer's Disease.Neurochem Res. 2018 Aug;43(8):1529-1538. doi: 10.1007/s11064-018-2567-y. Epub 2018 Jun 20.
2014 Ginsenoside Rg3 Prevents Cognitive Impairment by Improving Mitochondrial Dysfunction in the Rat Model of Alzheimer's Disease.J Agric Food Chem. 2019 Sep 11;67(36):10048-10058. doi: 10.1021/acs.jafc.9b03793. Epub 2019 Aug 27.
2015 Apathy in Preclinical Alzheimer's Disease: Psychometric Validation of the Apathy Evaluation Scale.Am J Alzheimers Dis Other Demen. 2019 Feb;34(1):16-22. doi: 10.1177/1533317518794020. Epub 2018 Aug 14.
2016 Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease.Neurobiol Aging. 2018 Dec;72:188.e3-188.e12. doi: 10.1016/j.neurobiolaging.2018.08.001. Epub 2018 Aug 9.
2017 Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain.J Neurochem. 2006 Jul;98(1):34-44. doi: 10.1111/j.1471-4159.2006.03801.x.
2018 Distinct microglia profile in Creutzfeldt-Jakob disease and Alzheimer's disease is independent of disease kinetics.Neuropathology. 2018 Dec;38(6):591-600. doi: 10.1111/neup.12517. Epub 2018 Oct 15.
2019 Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.ASN Neuro. 2010 Jul 12;2(3):e00037. doi: 10.1042/AN20100010.
2020 Knockdown of TNFAIP1 prevents di-(2-ethylhexyl) phthalate-induced neurotoxicity by activating CREB pathway.Chemosphere. 2020 Feb;241:125114. doi: 10.1016/j.chemosphere.2019.125114. Epub 2019 Oct 14.
2021 Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease.J Alzheimers Dis. 2019;67(1):91-102. doi: 10.3233/JAD-180797.
2022 Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice.J Neuroimmune Pharmacol. 2019 Sep;14(3):519-529. doi: 10.1007/s11481-019-09861-2. Epub 2019 Jul 8.
2023 Amelioration of amyloid--induced deficits by DcR3 in an Alzheimer's disease model.Mol Neurodegener. 2017 Apr 24;12(1):30. doi: 10.1186/s13024-017-0173-0.
2024 Cerebrospinal Fluid Concentrations of Extracellular Matrix Proteins in Alzheimer's Disease.J Alzheimers Dis. 2019;69(4):1213-1220. doi: 10.3233/JAD-190187.
2025 Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids.Biochem Biophys Res Commun. 1998 Jul 9;248(1):168-73. doi: 10.1006/bbrc.1998.8866.
2026 Toll-interacting protein deficiency promotes neurodegeneration via impeding autophagy completion in high-fat diet-fed ApoE(-/-) mouse model.Brain Behav Immun. 2017 Jan;59:200-210. doi: 10.1016/j.bbi.2016.10.002. Epub 2016 Oct 5.
2027 Amyloid-beta impairs TOM1-mediated IL-1R1 signaling.Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21198-21206. doi: 10.1073/pnas.1914088116. Epub 2019 Sep 30.
2028 Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer's Disease.J Alzheimers Dis. 2018;61(2):793-801. doi: 10.3233/JAD-170613.
2029 ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis.J Neurochem. 2003 May;85(3):801-9. doi: 10.1046/j.1471-4159.2003.01727.x.
2030 Alterations in adult hippocampal neurogenesis, aberrant protein s-nitrosylation, and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice.Iran J Basic Med Sci. 2017 Oct;20(10):1159-1165. doi: 10.22038/IJBMS.2017.9366.
2031 Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.Genet Mol Res. 2015 Aug 10;14(3):9361-9. doi: 10.4238/2015.August.10.17.
2032 Gender-related increase of tropomyosin-1 abundance in platelets of Alzheimer's disease and mild cognitive impairment patients.J Proteomics. 2018 Apr 30;178:73-81. doi: 10.1016/j.jprot.2017.12.018. Epub 2017 Dec 24.
2033 Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial.J Alzheimers Dis. 2019;72(4):1209-1216. doi: 10.3233/JAD-190757.
2034 Regulation of RAGE splicing by hnRNP A1 and Tra2-1 and its potential role in AD pathogenesis.J Neurochem. 2015 Apr;133(2):187-98. doi: 10.1111/jnc.13069. Epub 2015 Mar 2.
2035 No difference in expression of apoptosis-related proteins and apoptotic morphology in control, pathologically aged and Alzheimer's disease cases.Neurobiol Dis. 2006 May;22(2):323-33. doi: 10.1016/j.nbd.2005.11.010. Epub 2006 Jan 9.
2036 KCa3.1 Channel Modulators as Potential Therapeutic Compounds for Glioblastoma.Curr Neuropharmacol. 2018;16(5):618-626. doi: 10.2174/1570159X15666170630164226.
2037 Increased expression of tripartite motif (TRIM) like 2 promotes tumoral growth in human oral cancer.Biochem Biophys Res Commun. 2019 Jan 22;508(4):1133-1138. doi: 10.1016/j.bbrc.2018.12.060. Epub 2018 Dec 13.
2038 A Candidate Regulatory Variant at the TREM Gene Cluster Confer Alzheimer's Disease Risk by Modulating Both Amyloid- Pathology and Neuronal Degeneration.Front Neurosci. 2019 Jul 17;13:742. doi: 10.3389/fnins.2019.00742. eCollection 2019.
2039 A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population.Mol Neurobiol. 2017 Mar;54(2):977-982. doi: 10.1007/s12035-016-9706-8. Epub 2016 Jan 21.
2040 Review: Vascular dementia: clinicopathologic and genetic considerations.Neuropathol Appl Neurobiol. 2018 Apr;44(3):247-266. doi: 10.1111/nan.12472. Epub 2018 Mar 1.
2041 Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3162-3167. doi: 10.1073/pnas.1706100115. Epub 2018 Mar 6.
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2043 Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population.Neurosci Lett. 2005 May 13;379(3):149-51. doi: 10.1016/j.neulet.2004.12.056. Epub 2005 Jan 25.
2044 Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation.Front Aging Neurosci. 2019 Jan 25;10:432. doi: 10.3389/fnagi.2018.00432. eCollection 2018.
2045 In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15.Cell Mol Life Sci. 2018 Sep;75(17):3251-3267. doi: 10.1007/s00018-018-2791-2. Epub 2018 Mar 8.
2046 Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):217-230. doi: 10.1016/j.bbamcr.2016.11.003. Epub 2016 Nov 3.
2047 Male microchimerism in the human female brain.PLoS One. 2012;7(9):e45592. doi: 10.1371/journal.pone.0045592. Epub 2012 Sep 26.
2048 Caenorhabditis elegans hub genes that respond to amyloid beta are homologs of genes involved in human Alzheimer's disease.PLoS One. 2019 Jul 10;14(7):e0219486. doi: 10.1371/journal.pone.0219486. eCollection 2019.
2049 Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.Transl Psychiatry. 2019 Jan 31;9(1):55. doi: 10.1038/s41398-019-0394-9.
2050 CADPS2 gene expression is oppositely regulated by LRRK2 and alpha-synuclein.Biochem Biophys Res Commun. 2017 Aug 26;490(3):876-881. doi: 10.1016/j.bbrc.2017.06.134. Epub 2017 Jun 21.
2051 Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample.Int J Geriatr Psychiatry. 2016 Dec;31(12):1337-1344. doi: 10.1002/gps.4440. Epub 2016 Feb 14.
2052 Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons.Genomics. 2018 Mar;110(2):98-111. doi: 10.1016/j.ygeno.2017.09.001. Epub 2017 Sep 11.
2053 Glial Draper Rescues A Toxicity in a Drosophila Model of Alzheimer's Disease.J Neurosci. 2017 Dec 6;37(49):11881-11893. doi: 10.1523/JNEUROSCI.0862-17.2017. Epub 2017 Nov 6.
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