Details of the Drug

General Information of Drug (ID: DM3XU74)

Drug Name

Dornase Alfa

Synonyms

Pulmozyme (TN)

Indication

Disease Entry	ICD 11	Status	REF
Cystic fibrosis	CA25	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[2]
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Therapeutic Class

Enzyme Replacement Agents

Sequence

LKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAP
DTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFS
RFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQ
WSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYG
LSDQLAQAISDHYPVEVMLK

ADMET Property

Metabolism: The drug is metabolized via proteases in biofluids []

Cross-matching ID

DrugBank ID: DB00003
TTD ID: D0JE4D

Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Breaker	[3]

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Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	ClinicalTrials.gov (NCT04359654) Nebulised Dornase Alfa for Treatment of COVID-19. U.S. National Institutes of Health.
3	Dornase alfa. BioDrugs. 1997 Dec;8(6):439-45.