General Information of Disease (ID: DIS2OK1Q)

Disease Name Cystic fibrosis
Synonyms CF; mucoviscidosis; pseudomonas aeruginosa, susceptibility to chronic infection by, in cystic fibrosis; cystic fibrosis; cystic fibrosis lung disease, modifier of
Disease Class CA25: Cystic fibrosis
Definition Cystic fibrosis (CF) is a genetic disorder characterized by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity.
Disease Hierarchy
DISCPWH9: Autosomal recessive disease
DISGGAGJ: Respiratory disease
DIS2OK1Q: Cystic fibrosis
ICD Code
ICD-11
ICD-11: CA25
ICD-10
ICD-10: E84, E84.9
Disease Identifiers
MONDO ID
MONDO_0009061
MESH ID
D003550
UMLS CUI
C0010674
OMIM ID
219700
MedGen ID
41393
Orphanet ID
586
SNOMED CT ID
190905008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 13 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Actimmune DM3APM9 Approved NA [1]
Amikacin DM5PDRB Approved Small molecular drug [2]
Ciprofloxacin XR DM2NLS9 Approved Small molecular drug [3]
Dornase Alfa DM3XU74 Approved NA [4]
Dornase alpha DMN2G5Y Approved NA [5]
Esomeprazole DM7BN0X Approved Small molecular drug [6]
Glycine DMIOZ29 Approved Small molecular drug [7]
Ivacaftor DMZC1HS Approved Small molecular drug [8]
Mannitol DMSCDY9 Approved Small molecular drug [9]
Omeprazole DM471KJ Approved Small molecular drug [10]
Simvastatin DM30SGU Approved Small molecular drug [11]
Sitagliptin DMGDKXN Approved Small molecular drug [12]
Vardenafil DMTBGW8 Approved Small molecular drug [13]
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⏷ Show the Full List of 13 Drug(s)
This Disease is Treated as An Indication in 34 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Ataluren DM4GXW3 Phase 3 Small molecular drug [14]
CPL-7075 DM62E7C Phase 3 Small molecular drug [14]
Liprotamase DMNF4UH Phase 3 NA [15]
VX-661 DMJBXO3 Phase 3 Small molecular drug [14]
ABBV-2222 DM4ZLTY Phase 2 NA [17]
Amelubant DMUMCB9 Phase 2 Small molecular drug [18]
Camostat DMQ7UL8 Phase 2 Small molecular drug [19]
Carbon monoxide DMV707W Phase 2 Small molecular drug [20]
CTX-4430 DMU3KIF Phase 2 NA [14]
ELX-02 DMK3C4L Phase 2 Small molecule [21]
GLPG-1837 DMOCRYB Phase 2 NA [17]
Igmesine DMH97XA Phase 2 Small molecular drug [22]
INS-37217 DMF93RQ Phase 2 Small molecular drug [23]
KB001A DMTMCPZ Phase 2 Antibody [24]
L-694,458 DMA0DSJ Phase 2 Small molecular drug [25]
Lumacaftor DMCLWDJ Phase 2 Small molecular drug [26]
N91115 DM0759M Phase 2 NA [14]
OligoG CF-5/20 DMNZYR7 Phase 2 NA [27]
SB-656933 DMCY785 Phase 2 Small molecular drug [28]
VR179 DMTTHE9 Phase 2 NA [29]
VR496 DM5OUK9 Phase 2 NA [30]
VX-371 DMSTHG1 Phase 2 NA [31]
AR-501 DMZED0G Phase 1/2 Small molecular drug [32]
P-552-02 DM6V5OB Phase 1/2 Small molecular drug [33]
QR-010 DM5I1UG Phase 1/2 NA [14]
ABBV-2451 DMUCF9L Phase 1 NA [17]
ABBV-2737 DMU6K37 Phase 1 NA [17]
ABBV-3067 DMB01L5 Phase 1 NA [17]
CR-002 DMKWSFI Phase 1 NA [34]
POL-6014 DM9B68S Phase 1 NA [35]
RG6421 DMKB8KF Phase 1 NA [36]
SNSP113 DMNSRLW Phase 1 NA [37]
VX-522 DMO1D9E Phase 1 mRNA therapy [38]
isatin sulfonamide 34 DM21Y8J Clinical trial Small molecular drug [39]
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⏷ Show the Full List of 34 Drug(s)
This Disease is Treated as An Indication in 1 Drugs in Phase 3 Trial
Drug Name Drug ID Highest Status Drug Type REF
N-acetylcysteine DMBLID9 Phase 3 Trial Small molecular drug [16]
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This Disease is Treated as An Indication in 7 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
GR-213487 DMCXLIK Discontinued in Phase 2 NA [40]
HE-2000 DMWH4CY Discontinued in Phase 2 Small molecular drug [41]
P113D DM5WM01 Discontinued in Phase 2 NA [42]
TgAAV-CFTR DMQSNV8 Discontinued in Phase 2 NA [43]
ALP-242 DM592WE Terminated NA [45]
SYN-1134 DMG2SQM Terminated NA [46]
Tyloxapol DMR3S9B Terminated Small molecular drug [47]
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⏷ Show the Full List of 7 Drug(s)
This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CA-074Me DMVN3FU Preclinical Small molecular drug [44]
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This Disease is Treated as An Indication in 6 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
2CVV DMNNUOC Investigative NA [48]
Brevenal DMOL0O4 Investigative Small molecular drug [48]
Cystic fibrosis therapeutics DMEC2QI Investigative NA [48]
MCF DMLRPIS Investigative Small molecular drug [48]
OT-417 DM7TRRC Investigative NA [48]
PulmoXen DMKST3I Investigative NA [48]
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⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 152 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCG2 TTIMJ02 Limited Genetic Variation [49]
BPI TTXCSDR Limited Biomarker [50]
CEL TTTRNQW Limited Biomarker [51]
GLB1 TTNGJPH Limited Biomarker [52]
PDE5A TTJ0IQB Limited Genetic Variation [53]
SFTPD TTGLMU7 Limited Biomarker [54]
SLC6A14 TTB6H2S Limited Altered Expression [55]
SLC9A3 TTFZVPO Limited Biomarker [56]
SMPD1 TTJTM88 Limited Biomarker [57]
ABCC8 TTP835K moderate Altered Expression [58]
ARSB TTESQTG moderate Biomarker [59]
CAMP TTULOB6 moderate Biomarker [60]
CD14 TT6I7DC moderate Biomarker [61]
CELA1 TT3NKIB moderate Biomarker [62]
COL1A2 TTUABC1 moderate Genetic Variation [63]
CXCR1 TTMWT8Z moderate Biomarker [64]
CXCR2 TT30C9G moderate Genetic Variation [65]
DMD TTWLFXU moderate Genetic Variation [66]
EBP TT4VQZX moderate Biomarker [67]
EZR TTE47YC moderate Altered Expression [68]
HDAC6 TT5ZKDI moderate Biomarker [69]
KNG1 TTDJ4MY moderate Biomarker [70]
LIPE TTLUQ8E moderate Biomarker [71]
MDM4 TT9OUDQ moderate Biomarker [72]
PGD TTZ3IFB moderate Genetic Variation [73]
PRSS1 TT2WR1T moderate Altered Expression [74]
PRTN3 TT5MLC4 moderate Biomarker [75]
S100A9 TT0TMQG moderate Biomarker [76]
SCT TTOBVIN moderate Biomarker [77]
SLC26A4 TT7X02I moderate Biomarker [78]
TGM2 TT2F4OL moderate Biomarker [79]
TLR5 TTCXP8J moderate Biomarker [61]
TREM1 TTHZQP0 moderate Biomarker [80]
ABCA4 TTLB52K Strong Biomarker [81]
ABCC1 TTOI92F Strong Altered Expression [82]
ACO2 TTMTF2P Strong Biomarker [83]
ADRB2 TTG8ZWP Strong Genetic Variation [84]
AGTR2 TTQVOEI Strong Biomarker [85]
AIF1 TT12MEP Strong Biomarker [86]
ANK1 TTKFPMH Strong Biomarker [87]
ANO1 TTOJI4S Strong Biomarker [88]
ARRB2 TT8SO2I Strong Biomarker [89]
ATP2A2 TTE6THL Strong Altered Expression [90]
CA12 TTSYM0R Strong Genetic Variation [91]
CCL21 TTLZK1U Strong Genetic Variation [56]
CCNE2 TTLDRGX Strong Biomarker [92]
CDC25C TTESBNC Strong Biomarker [93]
CEACAM6 TTIGH2W Strong Biomarker [94]
CFI TT6ATLX Strong Biomarker [95]
CHIT1 TTDYX6T Strong Altered Expression [96]
CHRM3 TTQ13Z5 Strong Biomarker [97]
CLCA1 TT3AF4R Strong Biomarker [98]
CLCN2 TT30NW6 Strong Biomarker [99]
CLEC6A TTQ02HK Strong Biomarker [100]
COASY TT4YO0Z Strong Biomarker [101]
CSK TTX6F0Q Strong Altered Expression [102]
CTRC TT3RMNA Strong Genetic Variation [103]
CTSG TTQAJF1 Strong Biomarker [104]
CTSS TTUMQVO Strong Biomarker [105]
CXCL2 TTZF0K2 Strong Altered Expression [69]
DEFB4A TTIVY12 Strong Genetic Variation [106]
ENG TTB30LE Strong Biomarker [107]
ERN1 TTKIAT3 Strong Biomarker [108]
FCGR2A TTXT21W Strong Genetic Variation [109]
FGF10 TTNPEFX Strong Biomarker [110]
FGF19 TTGCH11 Strong Genetic Variation [111]
FURIN TTH9WF6 Strong Altered Expression [112]
FUT4 TTNV1KZ Strong Genetic Variation [113]
G3BP1 TTG0R8Z Strong Biomarker [114]
GBA TT1B5PU Strong Genetic Variation [115]
GCG TT6Y4PN Strong Altered Expression [116]
GHRHR TTG4R8V Strong Biomarker [117]
GIP TT40HS5 Strong Altered Expression [116]
GNAO1 TTAXD8Z Strong Genetic Variation [118]
GPNMB TT7315J Strong Altered Expression [59]
GPRC6A TTI1PRE Strong Genetic Variation [119]
GUCY2C TTLDPRG Strong Genetic Variation [120]
HBA2 TTQO71U Strong Biomarker [121]
HBB TTM6HK1 Strong Genetic Variation [122]
HEXA TTJI5JW Strong Genetic Variation [123]
HLA-DQB2 TTL7VOU Strong Genetic Variation [118]
HLA-G TTLKFB3 Strong Biomarker [124]
HMBS TTT0HW3 Strong Biomarker [125]
HTT TTIWZ0O Strong Biomarker [126]
IL31RA TT9HPX0 Strong Genetic Variation [127]
INPP5D TTTP2Z1 Strong Altered Expression [128]
ITK TT3C80U Strong Altered Expression [129]
KCNH2 TTQ6VDM Strong Biomarker [130]
KCNK3 TTGR91N Strong Biomarker [131]
KCNN4 TT7M9I6 Strong Biomarker [132]
KRT19 TT3JF9E Strong Genetic Variation [133]
LAMB3 TT2WOUQ Strong Biomarker [134]
LCT TTA0OSE Strong Genetic Variation [135]
LPAR3 TTE2YJR Strong Genetic Variation [119]
MARCKS TTHRM39 Strong Biomarker [136]
MASP2 TTR01E9 Strong Genetic Variation [137]
MGAM TTXWASR Strong Altered Expression [138]
MPO TTVCZPI Strong Biomarker [139]
MRGPRX1 TTIX6PK Strong Genetic Variation [119]
MUC1 TTBHFYQ Strong Biomarker [140]
MUC5AC TTEL90S Strong Biomarker [141]
NCR1 TTQNRJM Strong Biomarker [142]
OPRD1 TT27RFC Strong Genetic Variation [143]
OXER1 TT7WBSV Strong Genetic Variation [119]
P2RX1 TTJW7B3 Strong Altered Expression [144]
P2RX3 TT2THBD Strong Altered Expression [144]
P2RX4 TT1NLOA Strong Altered Expression [144]
P2RY11 TTYXPCO Strong Altered Expression [145]
P2RY2 TTOZHQC Strong Genetic Variation [146]
PAH TTGSVH2 Strong Biomarker [147]
PAM TTF4ZPC Strong Biomarker [148]
PAOX TTNQ760 Strong Genetic Variation [149]
PARP3 TTD8MEH Strong Biomarker [86]
PDE7A TT1BC3A Strong Biomarker [150]
PLOD1 TTEKJP3 Strong Biomarker [151]
PREP TTNGKET Strong Biomarker [152]
PRKCE TT57MT2 Strong Altered Expression [153]
PROKR2 TTM67AX Strong Altered Expression [154]
PRSS8 TTT4N0Q Strong Altered Expression [155]
RAPGEF3 TTOE7I0 Strong Biomarker [156]
RGMA TTURJV4 Strong Biomarker [157]
RGS2 TTKB7T3 Strong Biomarker [158]
RHO TTH0KSX Strong Altered Expression [159]
S100A8 TT4AF6N Strong Altered Expression [58]
SAA1 TTY0DN9 Strong Biomarker [160]
SERPINA6 TTJL8VG Strong Altered Expression [161]
SLC15A2 TT27Q3A Strong Altered Expression [162]
SLC1A5 TTF7WRM Strong Genetic Variation [163]
SLC23A2 TTOP832 Strong Altered Expression [164]
SLC26A9 TTKRVU0 Strong Genetic Variation [165]
SLC29A1 TTLXAKE Strong Biomarker [166]
SLC39A6 TTZN1CF Strong Biomarker [167]
SLC46A1 TTY8Z2E Strong Biomarker [150]
SP1 TTZEP6S Strong Altered Expression [168]
STK39 TTYQTIU Strong Biomarker [169]
STOML2 TTOI329 Strong Genetic Variation [170]
TAP1 TT7JZI8 Strong Biomarker [171]
TNFRSF1A TTG043C Strong Biomarker [172]
TNFSF13B TTWMIDN Strong Biomarker [173]
TRB TT84HCW Strong Genetic Variation [174]
TRBC1 TT1DHW2 Strong Genetic Variation [174]
TRH TT2Z39D Strong Biomarker [175]
TRPA1 TTELV3W Strong Biomarker [87]
TRPC3 TTNVC34 Strong Biomarker [176]
TRPC6 TTRBT3W Strong Biomarker [177]
TRPM4 TTJ2HKA Strong Altered Expression [178]
TRPV2 TTBECWA Strong Biomarker [179]
TRPV6 TTBK14N Strong Biomarker [177]
UBC TTBP3XA Strong Biomarker [92]
USP10 TT5IH09 Strong Biomarker [114]
UTS2R TTW5UDX Strong Biomarker [180]
VCP TTHNLSB Strong Biomarker [181]
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⏷ Show the Full List of 152 DTT(s)
This Disease Is Related to 14 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC27A5 DT0TQS3 Limited Biomarker [51]
ABCC11 DTWN7FC moderate Altered Expression [58]
ATP12A DT5NLZA moderate Altered Expression [78]
ABCB6 DTF9Y2V Strong Biomarker [182]
ABCC5 DTYVM24 Strong Biomarker [183]
SLC11A1 DT650XW Strong Biomarker [56]
SLC12A2 DTHKL3Q Strong Altered Expression [184]
SLC26A3 DTN1FMD Strong Biomarker [185]
SLC26A6 DTVGOLN Strong Biomarker [186]
SLC39A1 DTLWPXS Strong Biomarker [86]
SLC39A2 DTL8VXO Strong Biomarker [187]
SLC4A7 DT03V27 Strong Altered Expression [188]
SLC9A6 DTN0JXW Strong Biomarker [189]
CFTR DTEJNUG Definitive Autosomal recessive [190]
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⏷ Show the Full List of 14 DTP(s)
This Disease Is Related to 16 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
GSTT1 DE3PKUG Limited Genetic Variation [191]
GCLC DESYL1F moderate Genetic Variation [191]
SULT1E1 DESTKG6 moderate Biomarker [192]
APRT DE2MV1R Strong Biomarker [193]
CHDH DEAHED0 Strong Genetic Variation [194]
CPA4 DEXKD7J Strong Genetic Variation [195]
FNTA DEFNVD7 Strong Biomarker [196]
GSTM1 DEYZEJA Strong Genetic Variation [191]
LPO DEHX1DZ Strong Altered Expression [197]
MSRA DEU2ZBY Strong Altered Expression [198]
NDUFS7 DEIW03B Strong Genetic Variation [199]
NT5C2 DE1DOKJ Strong Altered Expression [200]
PCK1 DEPLH5Z Strong Altered Expression [201]
PGM3 DER0EN5 Strong Altered Expression [202]
PON2 DEHJU7E Strong Altered Expression [71]
SI DE5EO4Y Strong Altered Expression [138]
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⏷ Show the Full List of 16 DME(s)
This Disease Is Related to 195 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CELA3B OTGU8BE9 Limited Biomarker [203]
CLCA4 OTCRR1M9 Limited Altered Expression [204]
DEFB1 OT5SV0E4 Limited Biomarker [205]
LUM OTSRC874 Limited Genetic Variation [206]
PARP9 OT7K4494 Limited Biomarker [51]
SPX OTY3G4AR Limited Biomarker [207]
SUMF2 OT37I8JL Limited Biomarker [208]
A2M OTFTX90K moderate Biomarker [209]
BEST1 OTWHE1ZC moderate Biomarker [210]
CPOX OTIAY121 moderate Biomarker [67]
EHF OTY6TPWD moderate Biomarker [211]
FUT1 OTODG57A moderate Altered Expression [212]
HFE OTDD93KB moderate Genetic Variation [213]
IFRD1 OT4SQMLQ moderate Genetic Variation [214]
ISYNA1 OT49ONSE moderate Altered Expression [215]
KRT8 OTTM4X11 moderate Genetic Variation [216]
MSH3 OTD3YPVL moderate Biomarker [72]
SFTPA1 OT87XL1U moderate Genetic Variation [54]
TBC1D9 OTSSCTB5 moderate Altered Expression [217]
TBX22 OTT1RM26 moderate Biomarker [67]
ADGRE1 OTQQ9Q7G Strong Genetic Variation [218]
ADIPOR2 OT2HDTL8 Strong Genetic Variation [219]
AMFR OTQRX7LC Strong Genetic Variation [220]
AMN OTS1TJXG Strong Biomarker [221]
AMPD1 OTU17BCI Strong Biomarker [222]
AMPD2 OTBS30JU Strong Biomarker [222]
ASAH1 OT1DNGXL Strong Biomarker [223]
ASAH2 OT47TIF3 Strong Biomarker [224]
ASIC5 OT1KWTC1 Strong Genetic Variation [172]
ATF7IP OTU6ZA7F Strong Altered Expression [225]
ATG12 OTJRO09Y Strong Genetic Variation [226]
ATP5F1E OTMPLAIS Strong Biomarker [227]
ATP8B1 OTALGS63 Strong Biomarker [228]
AZU1 OTHXU264 Strong Biomarker [229]
BCAP31 OTKSACR4 Strong Genetic Variation [181]
BID OTOSHSHU Strong Genetic Variation [230]
BPIFB1 OTOZYJMO Strong Genetic Variation [231]
BPTF OTD1RZAD Strong Biomarker [232]
C1orf52 OT8RQW3W Strong Genetic Variation [233]
CALU OTSYQN71 Strong Genetic Variation [234]
CAPN10 OTS9LJW4 Strong Biomarker [235]
CAST OTBXZZGF Strong Biomarker [236]
CAV2 OT1FGRQX Strong Genetic Variation [237]
CDK2AP2 OTR99SJ8 Strong Biomarker [238]
CEACAM8 OTLL9WWO Strong Biomarker [239]
CELA3A OT9JAL80 Strong Biomarker [62]
CETN1 OTGQ8JOZ Strong Biomarker [240]
CHAC1 OTJGE772 Strong Biomarker [241]
CISD1 OT0MTVGF Strong Biomarker [242]
CLEC7A OTRTBH27 Strong Biomarker [100]
COMMD1 OT7WUD5R Strong Biomarker [243]
CRISPLD2 OTVSFHTL Strong Altered Expression [244]
CXCL6 OTFTCQ4O Strong Biomarker [245]
DCT OTYVNTBG Strong Biomarker [246]
DCTN4 OTM7C943 Strong Biomarker [114]
DCTN5 OTESGJ1N Strong Biomarker [195]
DEFB104A OTLQZR6K Strong Biomarker [106]
DELE1 OTXSTB64 Strong Genetic Variation [247]
DNAAF3 OT3OHO0O Strong Genetic Variation [248]
DNAH11 OT6IYFVV Strong Genetic Variation [249]
DNAH14 OTRCBQYM Strong Genetic Variation [248]
DNAH5 OTC21RUS Strong Biomarker [250]
DNAH6 OTUZNWKV Strong Genetic Variation [248]
DNAI1 OTF6C65Q Strong Biomarker [250]
EFNA5 OTOH4DRR Strong Genetic Variation [251]
ELF5 OTLRU8YF Strong Genetic Variation [211]
ELP2 OTBXG37N Strong Altered Expression [252]
ENPP7 OTWOBMQ9 Strong Biomarker [224]
ERN2 OTUS6GKR Strong Biomarker [253]
FAM13A OTZ6GN0Q Strong Biomarker [254]
FCN1 OTK6ZHXH Strong Genetic Variation [255]
FLNC OT3F8J6Y Strong Biomarker [256]
FOXI1 OT2UFOE2 Strong Genetic Variation [257]
FOXJ1 OT7LLBZ7 Strong Altered Expression [258]
FRMD7 OTJ11849 Strong Biomarker [259]
FSD1L OTBQ48RF Strong Altered Expression [260]
FXYD5 OT81DIOD Strong Altered Expression [261]
FZD4 OTGLZIE0 Strong Genetic Variation [119]
GBA2 OTOZXG5D Strong Altered Expression [262]
GBA3 OT86XWU2 Strong Altered Expression [161]
GC OTWS63BY Strong Biomarker [263]
GOPC OTRBGH71 Strong Genetic Variation [264]
GP2 OTB6TMGY Strong Biomarker [265]
GPR151 OT7EACU6 Strong Genetic Variation [119]
GSTM3 OTLA2WJT Strong Genetic Variation [266]
GYPA OTABU4YV Strong Genetic Variation [267]
GYPB OTESHUIX Strong Genetic Variation [267]
GYPE OTBHAG6A Strong Genetic Variation [267]
HAVCR1 OT184CRZ Strong Biomarker [268]
HBA1 OTW2BQF4 Strong Biomarker [121]
HCFC1 OT0UCK62 Strong Biomarker [269]
HGH1 OTY4H7ZZ Strong Genetic Variation [270]
HLA-DQA2 OT1DH0N9 Strong Genetic Variation [271]
HOXA2 OT6G6ZIK Strong Biomarker [117]
HSH2D OTOGB2BR Strong Biomarker [272]
HSPBAP1 OTRYDAZX Strong Biomarker [273]
IFI16 OT4SPU0U Strong Biomarker [92]
IFNGR1 OTCTQBWW Strong Biomarker [274]
ITFG1 OTX0PCR3 Strong Biomarker [275]
JMJD6 OTILR7E4 Strong Altered Expression [276]
KHSRP OTDHZARB Strong Altered Expression [277]
KRT13 OTTYSKGX Strong Biomarker [278]
KRT18 OTVLQFIP Strong Biomarker [279]
LAMTOR2 OTHEDISB Strong Biomarker [238]
LCN1 OT8BWXTV Strong Altered Expression [280]
LGALS14 OTOR23GX Strong Biomarker [99]
LGR6 OTPZ1PWR Strong Genetic Variation [119]
LMTK2 OT93MVIC Strong Biomarker [281]
LPCAT1 OTCV7AGV Strong Altered Expression [282]
LRRC26 OTXEFL76 Strong Altered Expression [283]
LRRC4 OT7XJ70N Strong Genetic Variation [233]
MARCHF1 OTI2EYO6 Strong Biomarker [284]
MASP1 OTWWCNZP Strong Genetic Variation [255]
MED18 OT6M6CQ8 Strong Biomarker [285]
METTL8 OT7E09Y4 Strong Biomarker [275]
MFAP1 OTZN4FT3 Strong Biomarker [193]
MMAA OTMAVZVO Strong Biomarker [286]
MOGS OT99MBGB Strong Biomarker [287]
MPI OTBH6ZK1 Strong Altered Expression [288]
MRGPRX3 OTRKCCDS Strong Genetic Variation [119]
MRGPRX4 OTOBHZVA Strong Genetic Variation [119]
MUC2 OT3X4QVX Strong Biomarker [289]
MUC20 OTYYE1GK Strong Biomarker [290]
MUC4 OTLT11V1 Strong Genetic Variation [290]
MUC5B OTPW6K5C Strong Altered Expression [253]
MUC6 OTPVL723 Strong Biomarker [291]
MUC7 OTSTMP0X Strong Altered Expression [292]
NCF4 OTX007YL Strong Biomarker [293]
ND4 OT4RQVAA Strong Altered Expression [294]
NLN OTFRITPU Strong Biomarker [295]
NLRC4 OTAIA3NA Strong Biomarker [296]
OAS1 OT8ZLOCY Strong Genetic Variation [297]
P2RX2 OT0LF34A Strong Altered Expression [144]
P2RX6 OT1FNTXA Strong Altered Expression [144]
PCBD1 OTDSRUD5 Strong Biomarker [250]
PI3 OT47MTC3 Strong Biomarker [298]
PIAS1 OTZVAHZI Strong Altered Expression [299]
PKD1 OT5ALRZ5 Strong Genetic Variation [300]
PLCB3 OT0OMDEM Strong Genetic Variation [301]
PLCD1 OT6WFVXZ Strong Biomarker [177]
PLCZ1 OTJ2MEFA Strong Altered Expression [302]
PLXNA3 OTMZIBVG Strong Biomarker [303]
POLD4 OTG578YH Strong Biomarker [304]
POLE4 OTCMWUT6 Strong Biomarker [304]
PPP2R1A OTYA3GB4 Strong Genetic Variation [305]
PTGES3 OTPPQWI0 Strong Altered Expression [306]
PTGR2 OTYPYOUM Strong Altered Expression [306]
RAB27A OT9SQRWY Strong Altered Expression [307]
RANGAP1 OTZGD3LJ Strong Biomarker [308]
RBP1 OTRP1MFC Strong Altered Expression [309]
RNF5 OTDQGI37 Strong Biomarker [310]
RPP14 OT4OYFSK Strong Biomarker [238]
RPS27A OTIIGGZ2 Strong Biomarker [92]
RPTOR OT4TQZ9F Strong Altered Expression [311]
RRP8 OTGZHVVW Strong Biomarker [312]
SAA2 OTYAVJWG Strong Biomarker [160]
SAG OTDNS3ZQ Strong Genetic Variation [313]
SCGB3A2 OTB63PHR Strong Altered Expression [314]
SCNN1B OT61QQTL Strong Biomarker [207]
SCNN1D OTTX2G9M Strong Biomarker [315]
SCNN1G OTSJYQVQ Strong Biomarker [316]
SDF4 OTQ7WFYW Strong Biomarker [240]
SELENOK OTKM7N7P Strong Biomarker [313]
SEPTIN3 OTOZ6PIM Strong Genetic Variation [317]
SERPINE2 OTYF5340 Strong Altered Expression [155]
SERPINF2 OTZGAF8B Strong Biomarker [318]
SF3B6 OTPRKS6S Strong Biomarker [238]
SFTPA2 OT6SFOMU Strong Biomarker [319]
SFTPB OTOHS07E Strong Genetic Variation [54]
SFTPC OTIZJD09 Strong Genetic Variation [54]
SH3BP4 OTVIRKW7 Strong Altered Expression [277]
SIPA1 OTXY5RXC Strong Biomarker [319]
SNAP23 OTY2MYBX Strong Genetic Variation [305]
SOCS2 OTBPNKJQ Strong Biomarker [320]
SPACA9 OTVRFX49 Strong Genetic Variation [321]
SPG21 OTMKJSYS Strong Genetic Variation [321]
SPINK1 OTSUVAL2 Strong Genetic Variation [103]
SRI OT4R3EAC Strong Biomarker [197]
STARD13 OTB4U1HY Strong Biomarker [299]
STIP1 OT7TXLOX Strong Genetic Variation [322]
STX1A OTSBUZB4 Strong GermlineModifyingMutation [323]
SUMF1 OTALXO2A Strong Biomarker [134]
SYTL2 OTUIOWKL Strong Genetic Variation [170]
SYTL3 OT6TPBA9 Strong Biomarker [170]
TAS2R38 OTX5MM36 Strong Altered Expression [324]
TCEA1 OTBFO594 Strong Genetic Variation [325]
TCFL5 OTJL4348 Strong Biomarker [326]
TIPRL OTS2FZ8O Strong Biomarker [275]
TLE5 OTEH0BFG Strong Altered Expression [327]
TMC6 OTKH50J4 Strong Genetic Variation [237]
TOM1 OT30QA56 Strong Biomarker [328]
TRPV5 OTWF4L0U Strong Biomarker [177]
TSPAN12 OTF9I3CX Strong Genetic Variation [329]
CFTR OT6B22QH Definitive Autosomal recessive [190]
SACS OTZGXQ8A Definitive Altered Expression [330]
------------------------------------------------------------------------------------
⏷ Show the Full List of 195 DOT(s)

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66 Detection of exonic copy-number changes using a highly efficient oligonucleotide-based comparative genomic hybridization-array method.Hum Mutat. 2008 Sep;29(9):1083-90. doi: 10.1002/humu.20829.
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68 Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.Sci Rep. 2017 Sep 7;7(1):10882. doi: 10.1038/s41598-017-11012-7.
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91 Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.Hum Mol Genet. 2016 May 15;25(10):1923-1933. doi: 10.1093/hmg/ddw065. Epub 2016 Feb 23.
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95 Sonographic pancreas echogenicity in cystic fibrosis compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI.PLoS One. 2018 Jul 26;13(7):e0201019. doi: 10.1371/journal.pone.0201019. eCollection 2018.
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118 Cystic fibrosis-related diabetes is associated with HLA DQB1 alleles encoding Asp-57- molecules.J Clin Immunol. 1994 Nov;14(6):353-8. doi: 10.1007/BF01546319.
119 2-Adrenergic receptor agonists activate CFTR in intestinal organoids and subjects with cystic fibrosis.Eur Respir J. 2016 Sep;48(3):768-79. doi: 10.1183/13993003.01661-2015. Epub 2016 Jul 28.
120 Guanylate cyclase 2C agonism corrects CFTR mutants.JCI Insight. 2017 Oct 5;2(19):e93686. doi: 10.1172/jci.insight.93686.
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123 Linear-after-the-exponential (LATE)-PCR: an advanced method of asymmetric PCR and its uses in quantitative real-time analysis.Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1933-8. doi: 10.1073/pnas.0305476101. Epub 2004 Feb 9.
124 HLA-G expression and regulation during Pseudomonas aeruginosa infection in cystic fibrosis patients.Future Microbiol. 2016;11(3):363-73. doi: 10.2217/fmb.15.143. Epub 2016 Mar 2.
125 The role of the UPS in cystic fibrosis.BMC Biochem. 2007 Nov 22;8 Suppl 1(Suppl 1):S11. doi: 10.1186/1471-2091-8-S1-S11.
126 Urinary metabolomics reveals unique metabolic signatures in infants with cystic fibrosis.J Cyst Fibros. 2019 Jul;18(4):507-515. doi: 10.1016/j.jcf.2018.10.016. Epub 2018 Nov 23.
127 Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid.J Nutr. 2009 Dec;139(12):2358-64. doi: 10.3945/jn.109.110999. Epub 2009 Oct 14.
128 Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8.J Biol Chem. 2011 Apr 1;286(13):11604-15. doi: 10.1074/jbc.M110.198390. Epub 2011 Jan 31.
129 Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators.Genomics. 2015 Nov;106(5):268-77. doi: 10.1016/j.ygeno.2015.07.005. Epub 2015 Jul 29.
130 hERG quality control and the long QT syndrome.J Physiol. 2016 May 1;594(9):2469-81. doi: 10.1113/JP270531. Epub 2016 Feb 9.
131 Functional and molecular identification of a TASK-1 potassium channel regulating chloride secretion through CFTR channels in the shark rectal gland: implications for cystic fibrosis.Am J Physiol Cell Physiol. 2016 Dec 1;311(6):C884-C894. doi: 10.1152/ajpcell.00030.2016. Epub 2016 Sep 21.
132 Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse.Sci Rep. 2018 Jun 18;8(1):9320. doi: 10.1038/s41598-018-27465-3.
133 CK19 stabilizes CFTR at the cell surface by limiting its endocytic pathway degradation.FASEB J. 2019 Nov;33(11):12602-12615. doi: 10.1096/fj.201901050R. Epub 2019 Aug 26.
134 Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation.Biochem Biophys Res Commun. 2019 Feb 5;509(2):521-528. doi: 10.1016/j.bbrc.2018.12.152. Epub 2018 Dec 28.
135 Mild CFTR mutations and genetic predisposition to lactase persistence in cystic fibrosis.Eur J Hum Genet. 2011 Jul;19(7):748-52. doi: 10.1038/ejhg.2011.36. Epub 2011 Mar 16.
136 A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma.Nat Med. 2004 Feb;10(2):193-6. doi: 10.1038/nm983. Epub 2004 Jan 11.
137 The mannan-binding lectin pathway and lung disease in cystic fibrosis--disfunction of mannan-binding lectin-associated serine protease 2 (MASP-2) may be a major modifier.Clin Immunol. 2006 Dec;121(3):324-31. doi: 10.1016/j.clim.2006.08.014. Epub 2006 Oct 12.
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143 Carbapenem resistance in cystic fibrosis strains of Pseudomonas aeruginosa as a result of amino acid substitutions in porin OprD.Int J Antimicrob Agents. 2015 May;45(5):529-32. doi: 10.1016/j.ijantimicag.2014.12.029. Epub 2015 Feb 12.
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