Details of the Drug

General Information of Drug (ID: DM4NKNK)

Drug Name

Selnoflast

Synonyms

Selnoflast; Selnoflast [INN]; Selnoflast [USAN]; T23RPA8WA2; RO7486967; Selnoflast [USAN:INN]; RG6418; 2260969-36-4; UNII-T23RPA8WA2; WHO 11687; RO-7486967; 1-Ethyl-N-(((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)amino)carbonyl)-4-piperidinesulfonamide; 1-ethyl-N-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]piperidine-4-sulfonamide; CHEMBL5095423; SCHEMBL20634304; GTPL12173; MFCD34579587; RG-6418; Example 6 [WO2019008025A1]; MS-26540; SY347075; HY-132831; CS-0204138; 1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea; 4-Piperidinesulfonamide, 1-ethyl-N-(((1,2,3,5,6,7-hexahydro-S-indacen-4-yl)amino)carbonyl)-; 4-Piperidinesulfonamide,1-ethyl-N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Phase 1	[1]
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Drug Type

Small molecule

Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C20H29N3O3S
Canonical SMILES: CCN1CCC(CC1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4
InChI: InChI=1S/C20H29N3O3S/c1-2-23-11-9-16(10-12-23)27(25,26)22-20(24)21-19-17-7-3-5-14(17)13-15-6-4-8-18(15)19/h13,16H,2-12H2,1H3,(H2,21,22,24)
InChIKey: OHIFQOUPTWBQLE-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 137402358
TTD ID: D7KRB9

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Caterpiller protein 1.1 (NLRP3)	TT4EN8X	NLRP3_HUMAN	Inhibitor	[1]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Clinical pipeline report, company report or official report of Roche