Details of the Drug

General Information of Drug (ID: DM4UHZF)

Drug Name
Vestronidase alfa
Indication
Disease Entry ICD 11 Status REF
Mucopolysaccharidosis 5C56.3 Approved [1]
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 3440 +/- 1430 mgmin/L []
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 20.0 +/- 8.1 mg/L []
Clearance
The total clearance of drug is 1.3 +/- 0.7 mL/min/kg []
Half-life
The concentration or amount of drug in body reduced by one-half in 155 +/- 37 minutes []
Metabolism
The drug is metabolized via the nonspecific proteolytic degradation into small peptides and amino acids []
Vd
The volume of distribution (Vd) of drug is 0.26 L/kg []
Cross-matching ID
DrugBank ID
DB12366
TTD ID
D0OY4K

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Beta-glucuronidase (GUSB) TTHS7CM BGLR_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.