Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTHS7CM)

• DTT Name: Beta-glucuronidase (GUSB)
• Synonyms: Beta-G1
• Gene Name: GUSB
• DTT Type: Successful target; [1]
• UniProt ID: BGLR_HUMAN
• TTD ID: T96413
• EC Number: EC 3.2.1.31
• Sequence:
  MARGSAVAWAALGPLLWGCALGLQGGMLYPQESPSRECKELDGLWSFRADFSDNRRRGFE
  EQWYRRPLWESGPTVDMPVPSSFNDISQDWRLRHFVGWVWYEREVILPERWTQDLRTRVV
  LRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADISNLVQVGPLPSRLRITIAINNTLTPTT
  LPPGTIQYLTDTSKYPKGYFVQNTYFDFFNYAGLQRSVLLYTTPTTYIDDITVTTSVEQD
  SGLVNYQISVKGSNLFKLEVRLLDAENKVVANGTGTQGQLKVPGVSLWWPYLMHERPAYL
  YSLEVQLTAQTSLGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFHGVNKHEDADIRGKG
  FDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRYGIVVIDECPGVGLALPQFFNN
  VSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYYLKMVIAHTKSLDPSRPVT
  FVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFENWYKKYQKPIIQSE
  YGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKRRKYVVGELIWNFADFMTEQSPTR
  VLGNKKGIFTRQRQPKSAAFLLRERYWKIANETRYPHSVAKSQCLENSLFT
• Function: Plays an important role in the degradation of dermatan and keratan sulfates.
• KEGG Pathway:
  Pentose and glucuronate interconversions (hsa00040)
  Ascorbate and aldarate metabolism (hsa00053)
  Glycosaminoglycan degradation (hsa00531)
  Porphyrin metabolism (hsa00860)
  Drug metabolism - other enzymes (hsa00983)
  Metabolic pathways (hsa01100)
  Biosynthesis of cofactors (hsa01240)
  Lysosome (hsa04142)
• Reactome Pathway:
  Hyaluronan uptake and degradation (R-HSA-2160916)
  MPS VII - Sly syndrome (R-HSA-2206292)
  Neutrophil degranulation (R-HSA-6798695)
  HS-GAG degradation (R-HSA-2024096)

Molecular Interaction Atlas (MIA) of This DTT

1 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vestronidase alfa	DM4UHZF	Mucopolysaccharidosis	5C56.3	Approved	[1]

1 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PerioPatch	DMFM6OU	Periodontal disease	DA0C	Phase 2	[2]

The Drug-Metabolizing Enzyme (DME) Role of This DTT

• DTT DME Name: Beta-glucuronidase (GUSB) DME Info
• Gene Name: GUSB

1 Approved Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[3]

1 Clinical Trial Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MK-4827	DMLYGH4	Ovarian cancer	2C73	Phase 3	[4]

1 Investigative Drug(s) Metabolized by This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tyropanoic acid	DM91UKB	N. A.	N. A.	Investigative	[5]

References

• [1] 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
• [2] Clinical pipeline report, company report or official report of Izun Pharmaceuticals.
• [3] MFN human ref: Chondroitin sulfate degradation.
• [4] Summary of FDA-approved anticancer cytotoxic drugs at May 2019.
• [5] Foreign Compound Metabolism in Mammals. Edited by D. E. Hathway.