Details of the Drug

General Information of Drug (ID: DM5K6J4)

Drug Name
AJM-300
Synonyms Alpha-4 integrin antagonist (inflammatory bowel disease), Ajinomoto
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Phase 3 [1]
Ulcerative colitis DD71 Phase 3 [2]
Cross-matching ID
PubChem CID
9872780
TTD ID
D0M1WU
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Integrin alpha-4/beta-1 (ITGA4/B1) TT6S84X ITA4_HUMAN-ITB1_HUMAN Modulator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019529)
2 Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
3 Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis. 2013 Dec;7(11):e533-42.