General Information of Disease (ID: DIS2C5Q8)

Disease Name Crohn disease
Synonyms Crohn's disease of large bowel; regional enteritis; paediatric Crohn's disease; Crohn disease; granulomatous colitis; pediatric Crohn's disease; Crohn's disease of colon; Crohn's disease
Disease Class DD70: Crohn disease
Definition
A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.
Disease Hierarchy
DISGN23E: Inflammatory bowel disease
DIS2C5Q8: Crohn disease
ICD Code
ICD-11
ICD-11: DD70
ICD-10
ICD-10: K50, K50.9
ICD-9
ICD-9: 555
Expand ICD-11
'DD70
Expand ICD-10
'K50; 'K50.9
Expand ICD-9
555
Disease Identifiers
MONDO ID
MONDO_0005011
MESH ID
D003424
UMLS CUI
C0010346
OMIM ID
266600
MedGen ID
3664
HPO ID
HP:0100280
Orphanet ID
206
SNOMED CT ID
34000006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 28 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Abatacept DMSA8RU Approved NA [1]
Adalimumab DMQMV1B Approved Antibody [2]
Aminosalicylic Acid DMENSL5 Approved Small molecular drug [3]
Betamethasone DMAHJEF Approved Small molecular drug [4]
Budesonide DMJIBAW Approved Small molecular drug [5]
Ciprofloxacin XR DM2NLS9 Approved Small molecular drug [6]
Citric acid, magnesium oxide, sodium picosulfate DMMEBWR Approved Small molecular drug [7]
Clofazimine DMEBOFW Approved Small molecular drug [8]
Cortisone Acetate DMG8K57 Approved Small molecular drug [9]
Desonide DMTP2NJ Approved Small molecular drug [10]
Dexamethasone DMMWZET Approved Small molecular drug [11]
Hydrocortisone DMGEMB7 Approved Small molecular drug [12]
Infliximab DMH7OIA Approved Antibody [2]
Mercaptopurine DMTM2IK Approved Small molecular drug [13]
Methylprednisolone DM4BDON Approved Small molecular drug [14]
Metronidazole DMTIVEN Approved Small molecular drug [15]
MLN0002 DMP2LZ8 Approved NA [16]
Mycophenolic acid DMRBMAU Approved NA [17]
Naltrexone DMUL45H Approved Small molecular drug [18]
Natalizumab DMAK85L Approved Monoclonal antibody [19]
Ozanimod DMT6AM2 Approved NA [20]
Plecanatide DMKEX7O Approved Small molecular drug [21]
Prednisolone DMQ8FR2 Approved Small molecular drug [22]
Prednisone DM2HG4X Approved Small molecular drug [23]
Ritlecitinib DMYKNME Approved NA [20]
Triamcinolone DM98IXF Approved Small molecular drug [24]
Upadacitinib DM32B5U Approved NA [20]
Vedolizmab DMV3YMX Approved Monoclonal antibody [17]
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⏷ Show the Full List of 28 Drug(s)
This Disease is Treated as An Indication in 60 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ABT-874 DMYHSO2 Phase 3 NA [25]
AJM-300 DM5K6J4 Phase 3 NA [26]
Alicaforsen DMQ509J Phase 3 Antisense drug [27]
Alofisel DMNKI8Y Phase 3 Cell therapy [28]
BI 655066 DMBH4FL Phase 3 Antibody [20]
Brazikumab DM4NWPE Phase 3 Monoclonal antibody [29]
Entyvio DMZVI9V Phase 3 NA [20]
Etrolizumab DMR87TR Phase 3 NA [20]
GED-0301 DMTUV7L Phase 3 NA [20]
GS-5745 DMP8MDW Phase 3 NA [20]
MSC-100-IV DM8EOG6 Phase 3 NA [20]
PB006 DMVHGLA Phase 3 Antibody [30]
Prochymal DMWTCWM Phase 3 NA [31]
Remestemcel-L DM02MRW Phase 3 Cell therapy [32]
RHB-104 DMWAYM7 Phase 3 NA [20]
Rifaximin DR DMKTS2M Phase 3 NA [20]
SB2 DMS1PFA Phase 3 NA [20]
SHP647 DMEWRXA Phase 3 NA [20]
SHR0302 DMUL8ZT Phase 3 Small molecule [33]
Sivelestat DM6BZCV Phase 3 Small molecular drug [20]
Vercirnon DM6L5ZQ Phase 3 Small molecular drug [34]
ABBV-154 DMVWLET Phase 2 Antibody drug conjugate [35]
Alequel DMH16BZ Phase 2 NA [20]
AMG-181 DMODJTX Phase 2 Antibody [36]
Anti-IP10 DMVRNAO Phase 2 Antibody [37]
APD371 DM3XT5V Phase 2 NA [38]
BI 706321 DMSLJZ8 Phase 2 NA [39]
CC-1088 DMQ874W Phase 2 Small molecular drug [40]
EB8018 DM753H8 Phase 2 Small molecular drug [42]
EGS-21 DMN1SWB Phase 2 Small molecular drug [43]
GLPG-0634 DMPHCDL Phase 2 Small molecular drug [20]
GSK2330811 DMB0CXT Phase 2 NA [44]
MDX-1100 DM0EZWI Phase 2 Antibody [45]
MEDI2070 DM8JGIA Phase 2 NA [46]
MORF-057 DMS274E Phase 2 Small molecule [47]
MT-1303 DMSE9TH Phase 2 Small molecular drug [20]
NN8555 DM3IEHP Phase 2 NA [20]
OPS-2071 DME8A5R Phase 2 Small interfering RNA [48]
PF-04236921 DM826SW Phase 2 NA [20]
PRA023 DMUY4VV Phase 2 Antibody [49]
SGX203 DMBBR3Y Phase 2 NA [20]
STA-5326 DMH4C3M Phase 2 Small molecular drug [50]
TEV-48574 DMHWN63 Phase 2 Antibody [51]
YSIL6 DM0K8U7 Phase 2 NA [52]
EcoActive DM5447L Phase 1/2 NA [53]
ABBV-323 DM49O6Y Phase 1 NA [20]
AMG-139 DMEHOVF Phase 1 Antibody [54]
ATR-107 DMBCATZ Phase 1 Antibody [55]
AZD7798 DMBE5OK Phase 1 Antibody [56]
C326 DMR0S8U Phase 1 NA [57]
CCX-025 DMCWVS7 Phase 1 NA [58]
ChronsVax DMAPEKO Phase 1 NA [20]
CrohnsVax DMFGYDQ Phase 1 NA [59]
ETX201 DMS436I Phase 1 NA [20]
ONS-3010 DMVMZ8M Phase 1 NA [20]
OSSM-001 DMQ8AD4 Phase 1 Cell therapy [60]
PF-06480605 DMCX5SX Phase 1 NA [61]
SAR252067 DM1OZ7O Phase 1 NA [62]
TAK-828 DMW43DL Phase 1 NA [20]
VBY-129 DM4YIWK Phase 1 NA [20]
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⏷ Show the Full List of 60 Drug(s)
This Disease is Treated as An Indication in 1 Drugs in Phase 2 Trial
Drug Name Drug ID Highest Status Drug Type REF
Clazakizumab DM6ZOUV Phase 2 Trial Monoclonal antibody [41]
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This Disease is Treated as An Indication in 188 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
Alkyl mannoside derivative 1 DMW57UB Patented Small molecular drug [63]
Alkyl mannoside derivative 10 DMHD51F Patented Carbohydrates [63]
Alkyl mannoside derivative 11 DMMNZ2U Patented Carbohydrates [63]
Alkyl mannoside derivative 12 DMX1OZF Patented Carbohydrates [63]
Alkyl mannoside derivative 2 DMNQUKP Patented Small molecular drug [63]
Alkyl mannoside derivative 3 DML2B58 Patented Carbohydrates [63]
Alkyl mannoside derivative 4 DMZR71O Patented Carbohydrates [63]
Alkyl mannoside derivative 5 DM04ZJ2 Patented Carbohydrates [63]
Alkyl mannoside derivative 6 DMCIV32 Patented Carbohydrates [63]
Alkyl mannoside derivative 7 DMBLSH1 Patented Carbohydrates [63]
Alkyl mannoside derivative 8 DMZP1JT Patented Carbohydrates [63]
Alkyl mannoside derivative 9 DMV1QUX Patented Carbohydrates [63]
Aryl mannoside derivative 1 DM1TV6F Patented Carbohydrates [63]
Aryl mannoside derivative 10 DM251GL Patented Carbohydrates [63]
Aryl mannoside derivative 11 DMRVIPL Patented Carbohydrates [63]
Aryl mannoside derivative 12 DMOG8XT Patented Carbohydrates [63]
Aryl mannoside derivative 13 DM2W7JE Patented Carbohydrates [63]
Aryl mannoside derivative 14 DMR648Z Patented Carbohydrates [63]
Aryl mannoside derivative 15 DMQS8CF Patented Carbohydrates [63]
Aryl mannoside derivative 16 DMP6QEC Patented Carbohydrates [63]
Aryl mannoside derivative 17 DM0FSPQ Patented Carbohydrates [63]
Aryl mannoside derivative 18 DM0YUBR Patented Carbohydrates [63]
Aryl mannoside derivative 19 DM6K29H Patented Carbohydrates [63]
Aryl mannoside derivative 2 DM4S2U5 Patented Carbohydrates [63]
Aryl mannoside derivative 20 DMZ2RV3 Patented Carbohydrates [63]
Aryl mannoside derivative 21 DMJBY68 Patented Carbohydrates [63]
Aryl mannoside derivative 22 DMJFDNB Patented Carbohydrates [63]
Aryl mannoside derivative 23 DMWUNRV Patented Carbohydrates [63]
Aryl mannoside derivative 3 DMF5XU8 Patented Carbohydrates [63]
Aryl mannoside derivative 4 DMO19Y6 Patented Carbohydrates [63]
Aryl mannoside derivative 5 DMMC31R Patented Carbohydrates [63]
Aryl mannoside derivative 6 DM5MIEC Patented Carbohydrates [63]
Aryl mannoside derivative 7 DM9YS40 Patented Carbohydrates [63]
Aryl mannoside derivative 8 DMK6PFQ Patented Carbohydrates [63]
Aryl mannoside derivative 9 DMNSK7U Patented Carbohydrates [63]
Beta-cyclodextrin conjugate derivative 1 DMZKTHL Patented Carbohydrates [63]
Beta-cyclodextrin conjugate derivative 2 DM9W1FO Patented Carbohydrates [63]
Beta-cyclodextrin conjugate derivative 3 DMQJF4P Patented Carbohydrates [63]
Beta-cyclodextrin conjugate derivative 4 DMO9RE8 Patented Carbohydrates [63]
Beta-cyclodextrin conjugate derivative 5 DML2B7G Patented Carbohydrates [63]
Biaryl mannoside derivative 1 DMX6YGS Patented Carbohydrates [63]
Biaryl mannoside derivative 10 DMPF37N Patented Carbohydrates [63]
Biaryl mannoside derivative 11 DMKES0G Patented Carbohydrates [63]
Biaryl mannoside derivative 12 DM5T29W Patented Carbohydrates [63]
Biaryl mannoside derivative 13 DM1Y8OM Patented Carbohydrates [63]
Biaryl mannoside derivative 14 DM4C5QY Patented Carbohydrates [63]
Biaryl mannoside derivative 15 DMKXT7H Patented Carbohydrates [63]
Biaryl mannoside derivative 16 DMP9742 Patented Carbohydrates [63]
Biaryl mannoside derivative 17 DMIXV6G Patented Carbohydrates [63]
Biaryl mannoside derivative 18 DMHOPE0 Patented Carbohydrates [63]
Biaryl mannoside derivative 19 DME8DQ0 Patented Carbohydrates [63]
Biaryl mannoside derivative 2 DMMB60X Patented Carbohydrates [63]
Biaryl mannoside derivative 20 DMNC5S0 Patented Carbohydrates [63]
Biaryl mannoside derivative 21 DMGSLHN Patented Carbohydrates [63]
Biaryl mannoside derivative 22 DMYLVB3 Patented Carbohydrates [63]
Biaryl mannoside derivative 23 DM2YVGH Patented Carbohydrates [63]
Biaryl mannoside derivative 24 DMF5TB4 Patented Carbohydrates [63]
Biaryl mannoside derivative 25 DMRM3E9 Patented Carbohydrates [63]
Biaryl mannoside derivative 26 DMYXLCJ Patented Carbohydrates [63]
Biaryl mannoside derivative 27 DMTDPHY Patented Carbohydrates [63]
Biaryl mannoside derivative 28 DMSNMZ2 Patented Carbohydrates [63]
Biaryl mannoside derivative 29 DMCLTY3 Patented Carbohydrates [63]
Biaryl mannoside derivative 3 DMAITK3 Patented Carbohydrates [63]
Biaryl mannoside derivative 30 DMPLAWQ Patented Carbohydrates [63]
Biaryl mannoside derivative 31 DMMPJ3E Patented Carbohydrates [63]
Biaryl mannoside derivative 4 DMVF63N Patented Carbohydrates [63]
Biaryl mannoside derivative 5 DMRS1WG Patented Carbohydrates [63]
Biaryl mannoside derivative 6 DMEWA7U Patented Carbohydrates [63]
Biaryl mannoside derivative 7 DMD7053 Patented Carbohydrates [63]
Biaryl mannoside derivative 8 DMWF2VG Patented Carbohydrates [63]
Biaryl mannoside derivative 9 DM1Q7AL Patented Carbohydrates [63]
Biphenyl mannoside derivative 1 DMS5UFX Patented Carbohydrates [63]
Biphenyl mannoside derivative 10 DMITLPW Patented Carbohydrates [63]
Biphenyl mannoside derivative 11 DMZF5XI Patented Carbohydrates [63]
Biphenyl mannoside derivative 12 DMU0YST Patented Carbohydrates [63]
Biphenyl mannoside derivative 13 DM83LTH Patented Carbohydrates [63]
Biphenyl mannoside derivative 14 DMMRTWG Patented Carbohydrates [63]
Biphenyl mannoside derivative 15 DM97BIQ Patented Carbohydrates [63]
Biphenyl mannoside derivative 16 DMECZVG Patented Carbohydrates [63]
Biphenyl mannoside derivative 17 DM7L8T5 Patented Carbohydrates [63]
Biphenyl mannoside derivative 18 DM2GZ5Y Patented Carbohydrates [63]
Biphenyl mannoside derivative 19 DMGA0R6 Patented Carbohydrates [63]
Biphenyl mannoside derivative 2 DMQB4DR Patented Carbohydrates [63]
Biphenyl mannoside derivative 20 DMDIYJ1 Patented Carbohydrates [63]
Biphenyl mannoside derivative 21 DMTR6BX Patented Carbohydrates [63]
Biphenyl mannoside derivative 22 DMQGFKY Patented Carbohydrates [63]
Biphenyl mannoside derivative 23 DMC8OVU Patented Carbohydrates [63]
Biphenyl mannoside derivative 24 DMLUZ3K Patented Carbohydrates [63]
Biphenyl mannoside derivative 25 DMBWQ8L Patented Carbohydrates [63]
Biphenyl mannoside derivative 26 DM5Q4T2 Patented Carbohydrates [63]
Biphenyl mannoside derivative 27 DMWQ6FJ Patented Carbohydrates [63]
Biphenyl mannoside derivative 28 DMMOTWK Patented Carbohydrates [63]
Biphenyl mannoside derivative 29 DM9H0Q3 Patented Carbohydrates [63]
Biphenyl mannoside derivative 3 DMOKJEP Patented Carbohydrates [63]
Biphenyl mannoside derivative 30 DM81RIY Patented Carbohydrates [63]
Biphenyl mannoside derivative 4 DM0VR23 Patented Carbohydrates [63]
Biphenyl mannoside derivative 5 DMOS03R Patented Carbohydrates [63]
Biphenyl mannoside derivative 6 DM93VEB Patented Carbohydrates [63]
Biphenyl mannoside derivative 7 DM46NRV Patented Carbohydrates [63]
Biphenyl mannoside derivative 8 DMZCWM5 Patented Carbohydrates [63]
Biphenyl mannoside derivative 9 DMP52HJ Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 1 DMV6H95 Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 2 DMJT1WG Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 3 DMY10T2 Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 4 DMRLE65 Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 5 DMUG7E9 Patented Carbohydrates [63]
C-linked disaccharide biphenyl mannoside derivative 6 DMUILMD Patented Carbohydrates [63]
Mannoside derivative 1 DMIE7U3 Patented Carbohydrates [63]
Mannoside derivative 10 DMZYRHN Patented Carbohydrates [63]
Mannoside derivative 11 DM8I051 Patented Carbohydrates [63]
Mannoside derivative 12 DM4QUY0 Patented Carbohydrates [63]
Mannoside derivative 13 DM0U7P9 Patented Carbohydrates [63]
Mannoside derivative 2 DMFEQD2 Patented Carbohydrates [63]
Mannoside derivative 3 DMPF2UG Patented Carbohydrates [63]
Mannoside derivative 4 DMZBY73 Patented Carbohydrates [63]
Mannoside derivative 5 DMMXNY8 Patented Carbohydrates [63]
Mannoside derivative 6 DMCM3NW Patented Carbohydrates [63]
Mannoside derivative 7 DMOUT1F Patented Carbohydrates [63]
Mannoside derivative 8 DMKTJAH Patented Carbohydrates [63]
Mannoside derivative 9 DMIKZXD Patented Carbohydrates [63]
PMID26651364-Compound-105 DMOJVK6 Patented Carbohydrates [63]
PMID26651364-Compound-106 DMQZJDF Patented Carbohydrates [63]
PMID26651364-Compound-107 DMMZ1WL Patented Carbohydrates [63]
PMID26651364-Compound-108 DMA7D3K Patented Carbohydrates [63]
PMID26651364-Compound-109 DM01IWV Patented Carbohydrates [63]
PMID26651364-Compound-10a DMTPBNY Patented Carbohydrates [63]
PMID26651364-Compound-10b DM16ANH Patented Carbohydrates [63]
PMID26651364-Compound-10c DMCRNWA Patented Carbohydrates [63]
PMID26651364-Compound-10d DMGIV3C Patented Carbohydrates [63]
PMID26651364-Compound-110 DMPA3IX Patented Carbohydrates [63]
PMID26651364-Compound-111 DMY9R58 Patented Carbohydrates [63]
PMID26651364-Compound-112 DM1LIRP Patented Carbohydrates [63]
PMID26651364-Compound-113 DM6OQKM Patented Carbohydrates [63]
PMID26651364-Compound-114 DM5GHJA Patented Carbohydrates [63]
PMID26651364-Compound-115 DMHIA26 Patented Carbohydrates [63]
PMID26651364-Compound-116 DMJ3201 Patented Carbohydrates [63]
PMID26651364-Compound-117a DM6LXHS Patented Carbohydrates [63]
PMID26651364-Compound-117b DMUQSM1 Patented Carbohydrates [63]
PMID26651364-Compound-118 DM6ZRV4 Patented Carbohydrates [63]
PMID26651364-Compound-119 DMONAZI Patented Carbohydrates [63]
PMID26651364-Compound-11b DMGBFK3 Patented Carbohydrates [63]
PMID26651364-Compound-11c DM76WBP Patented Carbohydrates [63]
PMID26651364-Compound-120 DMZTBEQ Patented Carbohydrates [63]
PMID26651364-Compound-121 DM4ZG0Q Patented Carbohydrates [63]
PMID26651364-Compound-122 DMVFTIL Patented Carbohydrates [63]
PMID26651364-Compound-123 DMR0E5W Patented Carbohydrates [63]
PMID26651364-Compound-124 DM6VER5 Patented Carbohydrates [63]
PMID26651364-Compound-125 DMINUDB Patented Carbohydrates [63]
PMID26651364-Compound-126a DMSTKH6 Patented Carbohydrates [63]
PMID26651364-Compound-126b DM2I1QZ Patented Carbohydrates [63]
PMID26651364-Compound-126c DM80PI1 Patented Carbohydrates [63]
PMID26651364-Compound-127 DMEN8RA Patented Carbohydrates [63]
PMID26651364-Compound-128 DM4W0BX Patented Carbohydrates [63]
PMID26651364-Compound-4 DMY0HP1 Patented Carbohydrates [63]
PMID26651364-Compound-45 DMLBZGO Patented Carbohydrates [63]
PMID26651364-Compound-46 DMQFDU8 Patented Carbohydrates [63]
PMID26651364-Compound-47 DM4S5PB Patented Carbohydrates [63]
PMID26651364-Compound-48 DMHXFGU Patented Carbohydrates [63]
PMID26651364-Compound-49 DMMV5A9 Patented Carbohydrates [63]
PMID26651364-Compound-5 DMH7XL3 Patented Carbohydrates [63]
PMID26651364-Compound-50 DM6GFYR Patented Carbohydrates [63]
PMID26651364-Compound-5a DM01GVE Patented Carbohydrates [63]
PMID26651364-Compound-5b DMLHJ1E Patented Carbohydrates [63]
PMID26651364-Compound-5c DMDQTA2 Patented Carbohydrates [63]
PMID26651364-Compound-5d DMF6Z5I Patented Carbohydrates [63]
PMID26651364-Compound-5e DM9TJR5 Patented Carbohydrates [63]
PMID26651364-Compound-5f DMAZIY6 Patented Carbohydrates [63]
PMID26651364-Compound-5g DMSW0HB Patented Carbohydrates [63]
PMID26651364-Compound-6a DM8HAJ3 Patented Carbohydrates [63]
PMID26651364-Compound-6b DMBINOJ Patented Carbohydrates [63]
PMID26651364-Compound-6c DMPF86L Patented Carbohydrates [63]
PMID26651364-Compound-6d DM9J57W Patented Carbohydrates [63]
PMID26651364-Compound-6e DM4LF0X Patented Carbohydrates [63]
PMID26651364-Compound-7a DMQMBY9 Patented Carbohydrates [63]
PMID26651364-Compound-7b DM3LCIM Patented Carbohydrates [63]
PMID26651364-Compound-7c DMGCUJB Patented Carbohydrates [63]
PMID26651364-Compound-7d DM89VQT Patented Carbohydrates [63]
PMID26651364-Compound-7e DM2SZ0B Patented Carbohydrates [63]
PMID26651364-Compound-8a DM1M3WF Patented Carbohydrates [63]
PMID26651364-Compound-8b DMYVU36 Patented Carbohydrates [63]
PMID26651364-Compound-8c DME7UNT Patented Carbohydrates [63]
PMID26651364-Compound-8d DMSO2F8 Patented Carbohydrates [63]
PMID26651364-Compound-9a DMAXWPS Patented Carbohydrates [63]
PMID26651364-Compound-9b DM6HTU0 Patented Carbohydrates [63]
PMID26651364-Compound-9c DM49V8G Patented Carbohydrates [63]
PMID26651364-Compound-9d DMF0L3E Patented Carbohydrates [63]
PMID26651364-Compound-9e DM9FIKD Patented Carbohydrates [63]
PMID26651364-Compound-9f DMF1MV6 Patented Carbohydrates [63]
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⏷ Show the Full List of 188 Drug(s)
This Disease is Treated as An Indication in 3 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CDP571 DM4HGMX Discontinued in Phase 3 NA [64]
ISIS 104838 DMURWPH Discontinued in Phase 2 Antisense drug [65]
TNFQb therapeutic vaccines DMTNB6G Terminated Vaccine [66]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
STP-432 DMINBOS Investigative NA [67]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 296 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ADRA1D TT34BHT Limited Genetic Variation [68]
ALDH5A1 TTJUWVB Limited Genetic Variation [69]
ANTXR2 TTOD34I Limited Genetic Variation [70]
APEH TTYWEDQ Limited Genetic Variation [71]
ATXN2 TTPQJ7P Limited Genetic Variation [72]
CCL11 TTCF05Y Limited Biomarker [73]
CCND3 TT1JXNR Limited Genetic Variation [72]
CD19 TTW640A Limited Biomarker [74]
CD24 TTCTYNP Limited Genetic Variation [75]
CD28 TTQ13FT Limited Biomarker [76]
CD83 TTT9MRQ Limited Altered Expression [77]
CDC37 TT5SOEU Limited Genetic Variation [72]
COL7A1 TTBCOKN Limited Biomarker [78]
CYP3A4 TTWP7HQ Limited Altered Expression [79]
DPP4 TTDIGC1 Limited Genetic Variation [80]
ENTPD1 TTYM8DJ Limited Altered Expression [81]
F13A1 TTXI2RA Limited Biomarker [82]
F9 TTFEZ5Q Limited Biomarker [83]
FCGR3A TTIFOC0 Limited Biomarker [84]
FKBP4 TTHY0FT Limited Biomarker [85]
FOXP3 TT1X3QF Limited Biomarker [86]
GNAO1 TTAXD8Z Limited Biomarker [87]
GRK5 TTTCXO0 Limited Genetic Variation [71]
HAMP TTRV5YJ Limited Altered Expression [88]
HDAC7 TTMUEK1 Limited Genetic Variation [70]
HLA-B TTGS10J Limited Genetic Variation [89]
HLA-DQB2 TTL7VOU Limited Biomarker [87]
HLA-G TTLKFB3 Limited Altered Expression [90]
HNF4A TT2F3CD Limited Biomarker [91]
IDO1 TTZJYKH Limited Altered Expression [92]
IL13RA2 TTMPZ7V Limited Altered Expression [93]
IL17D TTC5LTG Limited Altered Expression [94]
IL17F TT2B6PS Limited Biomarker [95]
IL18 TTRICUF Limited Genetic Variation [96]
IL21 TT9QEJ6 Limited Biomarker [97]
IL25 TTVMO5W Limited Altered Expression [98]
IL2RA TT10Y9E Limited Biomarker [99]
INPP5D TTTP2Z1 Limited Biomarker [100]
IRF1 TT4TU3L Limited Altered Expression [101]
ITGAE TTH0Z37 Limited Altered Expression [102]
JAK1 TT6DM01 Limited Biomarker [103]
KCNN1 TT9R6BE Limited Biomarker [104]
KEAP1 TT3Z6Y9 Limited Genetic Variation [70]
KLRK1 TTLRN4A Limited Biomarker [105]
KSR1 TTHL1TV Limited Genetic Variation [72]
LAMP1 TTC214J Limited Biomarker [106]
LAMP2 TTULDG7 Limited Biomarker [106]
LCT TTA0OSE Limited Genetic Variation [107]
LTBR TTFO0PM Limited Genetic Variation [72]
LYZ TTAOZBW Limited Genetic Variation [108]
MAS1 TTOISYB Limited Genetic Variation [109]
MLH1 TTISG27 Limited Biomarker [110]
MTHFR TTQWOU1 Limited Genetic Variation [111]
MUC17 TTVO0JU Limited Altered Expression [112]
MUC5AC TTEL90S Limited Biomarker [113]
NCF1 TTZ4JC3 Limited Biomarker [114]
NFKBIA TTSHAEB Limited Genetic Variation [115]
NOD1 TTYSRXM Limited Biomarker [116]
NPEPPS TT371QC Limited Genetic Variation [70]
NR1I2 TT7LCTF Limited Altered Expression [117]
NTF3 TTZHKV9 Limited Biomarker [104]
OSMR TTAH0KM Limited Genetic Variation [72]
P2RX7 TT473XN Limited Altered Expression [118]
PGA5 TTKZ864 Limited Genetic Variation [119]
PLA2G1B TT9V5JH Limited Genetic Variation [108]
PROC TTZUXYS Limited Genetic Variation [120]
PRTN3 TT5MLC4 Limited Biomarker [121]
PSEN2 TTWN3F4 Limited Altered Expression [122]
PSMB10 TTPNACM Limited Biomarker [123]
PTPRJ TTWMKXP Limited Altered Expression [124]
REG4 TTVZEHU Limited Altered Expression [125]
RHOA TTP2U16 Limited Genetic Variation [71]
RIC8B TT26BHC Limited Genetic Variation [70]
RIPK2 TTCQ2E5 Limited Biomarker [126]
RPS6KB1 TTG0U4H Limited Genetic Variation [70]
SH2B3 TT36N7Z Limited Genetic Variation [70]
SH3GL1 TTTYNAM Limited Biomarker [85]
SLC15A1 TT5LF3C Limited Biomarker [127]
SMAD3 TTHQZV7 Limited Biomarker [128]
TACR1 TTZPO1L Limited Biomarker [129]
TACR2 TTYO0A3 Limited Altered Expression [130]
TLR1 TTW14D0 Limited Genetic Variation [131]
TLR8 TT8CWFK Limited Genetic Variation [132]
TNFRSF1B TT63WSF Limited Biomarker [133]
TNFSF14 TTKVENM Limited Altered Expression [134]
TRB TT84HCW Limited Genetic Variation [135]
ULK1 TT4D7MJ Limited Genetic Variation [136]
VDAC1 TTAMKGB Limited Biomarker [137]
APOA4 TTNC3WS Disputed Altered Expression [138]
F11R TT3C8EG Disputed Altered Expression [139]
MAP3K1 TTW8TJI Disputed Genetic Variation [140]
MASP2 TTR01E9 Disputed Genetic Variation [141]
NPSR1 TTV1C0Z Disputed Genetic Variation [142]
VIPR1 TTCL30I Disputed Altered Expression [143]
ACO2 TTMTF2P moderate Genetic Variation [144]
ADAM17 TT6AZXG moderate Altered Expression [145]
ADAM30 TTAJDQY moderate Genetic Variation [144]
ANXA1 TTUCK4B moderate Altered Expression [146]
BRD2 TTDP48B moderate Genetic Variation [147]
CCL20 TT2XAZY moderate Biomarker [148]
CCR9 TTIPS8B moderate Biomarker [149]
CLN3 TTORF9W moderate Genetic Variation [150]
CX3CR1 TT2T98G moderate Biomarker [151]
DAG1 TT4X7PG moderate Genetic Variation [152]
DPEP1 TTYUENF moderate Biomarker [153]
EBI3 TTJF68X moderate Altered Expression [154]
ERAP2 TTVGS1C moderate Genetic Variation [72]
GCG TT6Y4PN moderate Biomarker [155]
GH1 TTT3YKH moderate Biomarker [156]
GPR18 TTSLJAR moderate Genetic Variation [144]
HSP90B1 TTFPKXQ moderate Altered Expression [157]
ICOSLG TTB9Z8R moderate Biomarker [158]
NLRP1 TTQX29T moderate Biomarker [159]
NT5E TTK0O6Y moderate Biomarker [160]
SLC10A2 TTPI1M5 moderate Altered Expression [161]
SLCO2A1 TTKVTQO moderate Biomarker [162]
TGFB2 TTI0KH6 moderate Biomarker [163]
AADAT TTT3IXG Strong Altered Expression [164]
ACAT1 TTK3C21 Strong Biomarker [165]
ADIPOQ TTXKA7D Strong Biomarker [166]
AGR2 TT9K86S Strong Altered Expression [167]
AHR TT037IE Strong Genetic Variation [168]
ALPI TTHYMUV Strong Altered Expression [169]
AOX1 TT3MOS2 Strong Genetic Variation [170]
ARRB2 TT8SO2I Strong Biomarker [171]
ATF3 TTCE793 Strong Biomarker [172]
ATG2B TTG6KCU Strong Biomarker [173]
CACNA1E TTYRP0M Strong Biomarker [174]
CAMP TTULOB6 Strong Biomarker [175]
CBR1 TTVG0SN Strong Biomarker [176]
CCL2 TTNAY0P Strong Genetic Variation [177]
CCL21 TTLZK1U Strong Genetic Variation [178]
CCR1 TTC24WT Strong Altered Expression [179]
CCR6 TTFDB30 Strong Genetic Variation [180]
CD160 TTOFEAS Strong Biomarker [95]
CD209 TTBXIM9 Strong Biomarker [181]
CD6 TTMF6KC Strong Genetic Variation [70]
CD86 TT53XHB Strong Biomarker [182]
CD96 TT83C4X Strong Genetic Variation [183]
CDH11 TTRGWZC Strong Altered Expression [184]
CDK5R1 TTBYM6V Strong Biomarker [185]
CFB TTA0P7K Strong Biomarker [186]
CHST15 TTFK7E1 Strong Biomarker [187]
CHUK TT1F8OQ Strong Biomarker [188]
CLEC12A TT70N8V Strong Biomarker [189]
CSF1 TT0IQER Strong Biomarker [190]
CSF2RA TT6MP2Z Strong Genetic Variation [191]
CSF2RB TTPYS82 Strong Genetic Variation [192]
CYP2A6 TTAQ6ZW Strong Genetic Variation [193]
CYP2J2 TTNE1C7 Strong Altered Expression [194]
DEFB4A TTIVY12 Strong Altered Expression [195]
DNASE1 TTYWGOJ Strong Biomarker [196]
DNMT3A TTJUALD Strong Genetic Variation [70]
DPP8 TTJGLZF Strong Altered Expression [197]
EPHB4 TTI4ZX2 Strong Genetic Variation [198]
EPHX2 TT7WVHI Strong Biomarker [199]
ERAP1 TT60XFL Strong Genetic Variation [70]
ERN1 TTKIAT3 Strong Biomarker [200]
ETS1 TTTGPSD Strong Genetic Variation [70]
FABP5 TTNT2S6 Strong Biomarker [201]
FADS2 TTT2VDU Strong Genetic Variation [72]
FAT1 TTGUJYV Strong Biomarker [202]
FCGR1A TTZK4I3 Strong Biomarker [203]
FCGR2A TTXT21W Strong Genetic Variation [204]
FFAR4 TT08JVB Strong Biomarker [205]
FGF7 TTFY134 Strong Biomarker [206]
FN1 TTPJ921 Strong Biomarker [207]
FOSL2 TT689IR Strong Biomarker [208]
FPR2 TTOJ1NF Strong Biomarker [209]
FUT3 TTUPAD7 Strong Genetic Variation [210]
GART TTEXB9Z Strong Biomarker [211]
GHR TTHJWYD Strong Altered Expression [212]
GLP2R TT1YWO5 Strong Altered Expression [213]
GPBAR1 TTSDVTR Strong Biomarker [214]
GPER1 TTDSB34 Strong Altered Expression [215]
GPR119 TT7QNVC Strong Altered Expression [216]
GPR3 TTHZVSK Strong Altered Expression [217]
GPR35 TT254XD Strong Genetic Variation [70]
GPR55 TTNET8J Strong Biomarker [218]
GSTA1 TT4P8DE Strong Biomarker [219]
GUCY2C TTLDPRG Strong Genetic Variation [220]
GUSB TTHS7CM Strong Genetic Variation [221]
HBB TTM6HK1 Strong Biomarker [222]
HDAC11 TT8K17W Strong Biomarker [223]
HDAC5 TTUELN5 Strong Altered Expression [224]
HGFAC TTD96RW Strong Altered Expression [225]
HPN TT25MVL Strong Biomarker [226]
HTR7 TTO9X1H Strong Biomarker [182]
IDO2 TTALN9W Strong Genetic Variation [227]
IFNGR2 TT13TL0 Strong Genetic Variation [228]
IGF1 TTT6LOU Strong Altered Expression [156]
IL10RB TTJTRMK Strong Genetic Variation [229]
IL11 TTGUYTR Strong Genetic Variation [230]
IL12A TTRTK6Y Strong Biomarker [185]
IL12B TTGW72V Strong Genetic Variation [228]
IL12RB2 TT4SWR8 Strong Biomarker [231]
IL13 TT0GVCH Strong Biomarker [232]
IL15RA TTGN89I Strong Altered Expression [233]
IL16 TTW4R0B Strong Altered Expression [234]
IL18RAP TTZUJVE Strong Genetic Variation [144]
IL19 TT87RWS Strong Genetic Variation [70]
IL1R1 TTWOTEA Strong Biomarker [235]
IL1RL1 TT4GZA4 Strong Genetic Variation [72]
IL21R TTZO9B0 Strong Altered Expression [236]
IL24 TT1EPXZ Strong Biomarker [237]
IL33 TT5MD4P Strong Biomarker [238]
IL37 TTQTX98 Strong Genetic Variation [239]
IL5 TTPREZD Strong Altered Expression [240]
IL7 TT8FRMO Strong Biomarker [241]
IRAK1 TTXAJWN Strong Biomarker [242]
IRAK3 TTBPJOK Strong Biomarker [242]
IRF8 TTHUBNK Strong Genetic Variation [243]
ITGAL TT48WR6 Strong Genetic Variation [70]
JAK2 TTRMX3V Strong Genetic Variation [244]
KCNQ2 TTPXI3S Strong Biomarker [245]
KIR2DL2 TTU0P73 Strong Genetic Variation [246]
KIR2DL3 TTEX3SI Strong Genetic Variation [246]
KIR2DS1 TTVWAGF Strong Genetic Variation [247]
KIR3DL2 TTQH3N0 Strong Biomarker [248]
LANCL2 TTMK3EX Strong Biomarker [86]
LBP TTVQJLY Strong Altered Expression [249]
LCN2 TTKTLAI Strong Altered Expression [250]
LEP TTBJEZ5 Strong Biomarker [251]
LRRK2 TTK0FEA Strong Genetic Variation [252]
LTA TTP73TM Strong Genetic Variation [170]
LTF TTSZDQU Strong Biomarker [253]
LY96 TT8S9AV Strong Genetic Variation [115]
MAP3K14 TT4LIAC Strong Genetic Variation [254]
MAP3K7 TTJQT60 Strong Altered Expression [255]
MAP3K8 TTGECUM Strong Genetic Variation [72]
MMP10 TTXLEG7 Strong Biomarker [256]
MMP3 TTUZ2L5 Strong Biomarker [257]
MST1R TTBQ3OC Strong Genetic Variation [258]
MYLK2 TTHLGB2 Strong Biomarker [259]
NELL1 TT7H4BF Strong Biomarker [260]
NFKB1 TTUIZKC Strong Genetic Variation [261]
NLRP3 TT4EN8X Strong Genetic Variation [262]
NPR1 TTM9IYA Strong Biomarker [263]
NPR3 TTWVLS6 Strong Biomarker [220]
NR0B1 TTTK36V Strong Biomarker [264]
NR1H4 TTS4UGC Strong Biomarker [265]
NR5A2 TTAU3SY Strong Genetic Variation [70]
OPRD1 TT27RFC Strong Biomarker [266]
PDCD1LG2 TTW14O3 Strong Biomarker [267]
PLA2G2A TTO8QRU Strong Altered Expression [268]
PLA2G4A TTT1JVS Strong Genetic Variation [144]
PPARA TTJ584C Strong Biomarker [265]
PPARG TTT2SVW Strong Altered Expression [269]
PRKCB TTYPXQF Strong Genetic Variation [70]
PRKCQ TT1MS7X Strong Genetic Variation [270]
PSMB9 TTOUSTQ Strong Genetic Variation [271]
PTGER4 TT79WV3 Strong Biomarker [91]
PTPN2 TTY8PUS Strong Biomarker [272]
RPGR TTHBDA9 Strong Genetic Variation [273]
RSPO3 TT7HJTF Strong Genetic Variation [72]
SELL TT2IYXF Strong Genetic Variation [274]
SLC1A5 TTF7WRM Strong Altered Expression [275]
SLC22A1 TTM5Q4V Strong Genetic Variation [276]
SLC23A1 TT6XAGK Strong Genetic Variation [277]
SLCO3A1 TT5CE6L Strong Biomarker [278]
SPN TTOZAX0 Strong Biomarker [279]
ST14 TTPRO7W Strong Altered Expression [280]
SUCNR1 TT4FX9Y Strong Altered Expression [281]
TAP1 TT7JZI8 Strong Biomarker [282]
TBX21 TTNF9PH Strong Genetic Variation [228]
TFF1 TTNOJIZ Strong Biomarker [283]
TKT TT04R7I Strong Biomarker [284]
TLR9 TTSHG0T Strong Altered Expression [285]
TNFAIP3 TT5W0IO Strong Biomarker [286]
TNFRSF14 TTWGTC1 Strong Genetic Variation [70]
TNFRSF1A TTG043C Strong Altered Expression [287]
TNFRSF25 TTDV6BQ Strong Biomarker [288]
TNK2 TTIET93 Strong Altered Expression [289]
TSLP TTHMW3T Strong Biomarker [290]
UGT1A1 TT34ZAF Strong Genetic Variation [291]
VSIR TT51SK8 Strong Altered Expression [292]
ZAP70 TTUMHT8 Strong Genetic Variation [293]
ADORA3 TTJFY5U Definitive Biomarker [294]
AOC1 TTM3B5R Definitive Genetic Variation [295]
CCR3 TTD3XFU Definitive Altered Expression [296]
CDH3 TTARMD9 Definitive Genetic Variation [243]
DHPS TTBO2A9 Definitive Biomarker [297]
ELAVL1 TTPC9D0 Definitive Biomarker [298]
GRB2 TTEYRJ9 Definitive Biomarker [299]
IL3RA TTENHJ0 Definitive Genetic Variation [300]
KCNN4 TT7M9I6 Definitive Genetic Variation [301]
LPAR6 TTZDAGB Definitive Biomarker [294]
LTB TTHQ6US Definitive Genetic Variation [302]
MGLL TTZ963I Definitive Biomarker [303]
P2RY14 TT72OKI Definitive Biomarker [294]
PDX1 TT8SGZK Definitive Altered Expression [304]
PSMB6 TT8EPLT Definitive Biomarker [305]
RORC TTGV6LY Definitive Altered Expression [306]
SAA1 TTY0DN9 Definitive Altered Expression [257]
STK4 TTCPLVN Definitive Altered Expression [307]
TLR6 TTWRI8V Definitive Genetic Variation [308]
------------------------------------------------------------------------------------
⏷ Show the Full List of 296 DTT(s)
This Disease Is Related to 8 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC39A11 DTEOAND Limited Genetic Variation [70]
SLC39A8 DTLPQGT Limited Genetic Variation [309]
SLC9A8 DTNY0C2 Limited Genetic Variation [70]
SLC22A23 DTMJK12 moderate Genetic Variation [144]
SLC12A2 DTHKL3Q Strong Altered Expression [310]
SLC25A20 DTQOUM4 Strong Biomarker [311]
SLC28A3 DT4YL5R Strong Altered Expression [312]
SLC14A2 DT8QC7K Definitive Genetic Variation [257]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DTP(s)
This Disease Is Related to 21 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
NAT2 DER7TA0 Limited Genetic Variation [313]
PARK7 DEPOVCH Limited Genetic Variation [70]
TPMT DEFQ8VO Limited Altered Expression [314]
UGT1A7 DEZO4N3 Limited Biomarker [315]
PON3 DETXQZ1 Disputed Biomarker [316]
ACSS2 DEE76VW moderate Genetic Variation [317]
CYP26B1 DEZT8FM Strong Genetic Variation [318]
CYP4F3 DEFCMPI Strong Genetic Variation [319]
EGLN3 DEMQTKH Strong Biomarker [320]
EPHX1 DELB4KP Strong Biomarker [321]
FAAH DEUM1EX Strong Altered Expression [322]
FADS1 DE05S8C Strong Biomarker [319]
G6PC3 DEE1B8O Strong Biomarker [323]
HPGD DEHKSC6 Strong Biomarker [324]
IPMK DESA9EX Strong Genetic Variation [325]
KYAT1 DES9MCU Strong Altered Expression [164]
MAT1A DEQ6NC9 Strong Biomarker [165]
NDUFS7 DEIW03B Strong Genetic Variation [326]
P4HA2 DE5EGK0 Strong Genetic Variation [327]
XPNPEP1 DE8E6X9 Strong Biomarker [328]
CYP4F2 DE3GT9C Definitive Genetic Variation [302]
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 DME(s)
This Disease Is Related to 409 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACTA2 OTEDLG8E Limited Genetic Variation [70]
ADCY3 OTGOQM6B Limited Genetic Variation [72]
AMT OTQYEWZQ Limited Genetic Variation [71]
ANKRD55 OT62KZII Limited Genetic Variation [70]
ASAP2 OTGEXULW Limited Genetic Variation [70]
ATN1 OTNZFLKY Limited Biomarker [116]
BACH2 OT17GS18 Limited Genetic Variation [329]
BANK1 OTXAAA11 Limited Genetic Variation [72]
BCAS3 OTDVAX6B Limited Genetic Variation [71]
BCL3 OT1M5B95 Limited Biomarker [242]
C17orf67 OTCL5EE8 Limited Genetic Variation [70]
C1orf141 OTASPHL0 Limited Genetic Variation [330]
CCL19 OTQ2UJMH Limited Biomarker [331]
CCL25 OTLWJ8CJ Limited Altered Expression [332]
CCNY OTK1KG5W Limited Genetic Variation [333]
CD226 OT4UG0KB Limited Genetic Variation [70]
CDAN1 OTCVZRG6 Limited Altered Expression [334]
CDKAL1 OTA0SGNE Limited Genetic Variation [72]
CDKN2D OT2TTZPZ Limited Biomarker [83]
CMC1 OTCWYKPI Limited Genetic Variation [70]
CPEB4 OTW1SCZW Limited Genetic Variation [70]
CREM OTJIJ5AL Limited Genetic Variation [72]
CUL1 OTXPE1UZ Limited Genetic Variation [72]
CUZD1 OTDQJVZ8 Limited Biomarker [335]
CXCL6 OTFTCQ4O Limited Altered Expression [336]
DAP OT5YLL7E Limited Genetic Variation [72]
DDX39A OT0Z6E1K Limited Genetic Variation [337]
DECR1 OTCDIR6X Limited Genetic Variation [338]
DEFA1 OT5N1B9B Limited Biomarker [339]
ECD OT3L3PCU Limited Altered Expression [340]
EFNB2 OT0DCUOM Limited Altered Expression [341]
FAM118A OT6EM97E Limited Genetic Variation [70]
FAM171B OT4DJHCM Limited Genetic Variation [72]
FAM177A1 OTXTA14N Limited Genetic Variation [70]
FEN1 OT6QGG7O Limited Genetic Variation [72]
FERMT1 OT626PBA Limited Genetic Variation [72]
FIBP OTI7131S Limited Genetic Variation [70]
FNDC3A OTUX3S2I Limited Genetic Variation [70]
GAL3ST2 OTZT1PLE Limited Genetic Variation [70]
GLYAT OT3WWYXD Limited Genetic Variation [70]
GNA12 OT3IRZH3 Limited Genetic Variation [70]
GPR65 OTCF5O4G Limited Genetic Variation [72]
HIPK1 OTSEA8RS Limited Genetic Variation [70]
HMMR OT4M0JTZ Limited Biomarker [342]
HORMAD2 OTL2ENWI Limited Genetic Variation [72]
IFIH1 OTZA2AHA Limited Genetic Variation [70]
IGSF6 OT5TUH02 Limited Biomarker [343]
IL18R1 OT83XMPQ Limited Genetic Variation [72]
IL26 OT2WYCW4 Limited Biomarker [344]
IL27 OTIS3OF8 Limited Genetic Variation [330]
IL6ST OT1N9C70 Limited Altered Expression [345]
IMPG2 OTFPSJ0T Limited Genetic Variation [72]
INAVA OTGXNB86 Limited Genetic Variation [72]
INKA2 OT9RA64U Limited Genetic Variation [330]
ISG20 OTCWRJJW Limited Biomarker [99]
ITGAX OTOGIMHE Limited Biomarker [346]
ITPA OTQ47WVR Limited Genetic Variation [347]
JAZF1 OTXTYSYD Limited Genetic Variation [70]
KAT5 OTL7257A Limited Altered Expression [348]
LACC1 OT4SBHI8 Limited Genetic Variation [349]
LPP OT6TU8SE Limited Genetic Variation [72]
LYRM4 OTK6JCKL Limited Genetic Variation [350]
MICA OTPEIEAR Limited Altered Expression [351]
MUC5B OTPW6K5C Limited Altered Expression [352]
MYRF OTKF6AEB Limited Genetic Variation [70]
NDFIP1 OTIORSWF Limited Genetic Variation [72]
NFATC1 OT4TMERS Limited Genetic Variation [70]
NICN1 OTAMQ4EI Limited Genetic Variation [71]
NPL OTA7P0TO Limited Biomarker [353]
OPTN OT2UXWH9 Limited Biomarker [354]
OSBPL3 OT9G194Y Limited Genetic Variation [71]
PI3 OT47MTC3 Limited Altered Expression [355]
PKIG OTOIWE5G Limited Genetic Variation [70]
PLCL1 OTJL2C79 Limited Genetic Variation [72]
PPP2R3C OT7E6V9B Limited Genetic Variation [70]
PSORS1C1 OT9HK436 Limited Genetic Variation [356]
RAVER1 OTMHBTLE Limited Genetic Variation [70]
RDX OTNSYUN6 Limited Genetic Variation [70]
REG1A OTMHUH1D Limited Biomarker [83]
RFT1 OTW82NET Limited Genetic Variation [72]
RMI2 OTA0HP4S Limited Genetic Variation [72]
RTEL1 OTI3PJCT Limited Genetic Variation [350]
SBNO2 OT1C6J3K Limited Genetic Variation [72]
SCAMP3 OTUNPYCE Limited Genetic Variation [72]
SCYL1 OTQ0IN7P Limited Biomarker [123]
SEMA6A OTDQ7QAW Limited Genetic Variation [350]
SETD1A OTVVWRIC Limited Genetic Variation [70]
SFXN1 OTL66767 Limited Genetic Variation [357]
SKAP2 OTSF44KP Limited Genetic Variation [70]
SLAMF8 OTATVST8 Limited Genetic Variation [72]
STK11 OT1YZSP3 Limited Genetic Variation [70]
TCF4 OTB9ASTK Limited Altered Expression [358]
TEX9 OTMYCDCW Limited Genetic Variation [71]
TFF3 OTJJDRTU Limited Altered Expression [359]
TG OT3ELHIJ Limited Biomarker [360]
THADA OTYZQX0F Limited Genetic Variation [72]
TMEM258 OTXSDU14 Limited Genetic Variation [70]
TNFSF9 OTV9L89D Limited Biomarker [361]
TNIP1 OTRAOTEW Limited Genetic Variation [70]
TRAF3IP2 OTLLZERL Limited Biomarker [362]
TSPAN14 OT29167O Limited Genetic Variation [72]
ACKR2 OTWYY14H Disputed Altered Expression [363]
ARHGDIA OTEXWJDO Disputed Altered Expression [364]
DNTT OTFSEF12 Disputed Genetic Variation [365]
FCN3 OTPRENLS Disputed Genetic Variation [141]
MUC12 OTYDC13T Disputed Biomarker [366]
MUC13 OTWKS9MF Disputed Genetic Variation [366]
NFKBIL1 OTYFTPS0 Disputed Genetic Variation [367]
NLRC4 OTAIA3NA Disputed Genetic Variation [368]
PIGR OT6GLSUL Disputed Altered Expression [369]
PLA2G10 OTRZ2L5A Disputed Altered Expression [370]
PROSER1 OTV1Y4ON Disputed Genetic Variation [371]
RAD50 OTYMU9G1 Disputed Genetic Variation [372]
TNFRSF10C OTVHOL9B Disputed Altered Expression [373]
ACCS OTHIHI9D moderate Genetic Variation [317]
ADCY7 OTAWMGP3 moderate Genetic Variation [152]
ADGRL2 OTCXD2YR moderate Genetic Variation [152]
ANKRD30A OTJXYAE5 moderate Genetic Variation [152]
ATXN2L OTP5M3R9 moderate Genetic Variation [152]
CAVIN1 OTFO915U moderate Genetic Variation [150]
CD244 OTSMR85N moderate Genetic Variation [150]
CDC42SE2 OT8SG9I1 moderate Genetic Variation [144]
CELSR3 OT8P6QNJ moderate Genetic Variation [144]
CHI3L1 OT2Z7VJH moderate Biomarker [374]
CLCA2 OTF191LZ moderate Genetic Variation [375]
CRB1 OTXYUNG0 moderate Genetic Variation [152]
CRTC3 OTVIGVUW moderate Genetic Variation [144]
DEFA6 OTDJADMQ moderate Biomarker [376]
DOCK7 OTINNVQV moderate Genetic Variation [144]
DUOX2 OTU14HCN moderate Genetic Variation [377]
ECM1 OT1K65VW moderate Biomarker [378]
ELF1 OTV5LKIA moderate Genetic Variation [271]
FCGR3B OTSLSPZG moderate Biomarker [84]
FNBP1 OTSJ5KKA moderate Genetic Variation [152]
IL10RA OTOX3D1D moderate Genetic Variation [379]
INS-IGF2 OTZR74BO moderate Genetic Variation [152]
INTS11 OTOFT19G moderate Genetic Variation [144]
IRF5 OT8SIIAP moderate Genetic Variation [380]
LITAF OTT5JX1F moderate Genetic Variation [144]
LURAP1L OTSJ29M5 moderate Genetic Variation [152]
MAGI1 OTMV4ASV moderate Genetic Variation [375]
MNAT1 OTXLOYCB moderate Genetic Variation [381]
NKD1 OTY3MO97 moderate Genetic Variation [152]
ORMDL3 OTAB7MZF moderate Biomarker [382]
PLA2G15 OT6VJTPA moderate Genetic Variation [317]
PNKD OT6G9UXN moderate Genetic Variation [144]
RASGRP1 OTX9WN2E moderate Genetic Variation [144]
RGS14 OTYN79AG moderate Genetic Variation [144]
RIT1 OTVNOGOH moderate Genetic Variation [144]
SBSPON OTBHAW5K moderate Genetic Variation [383]
SGSM3 OTIB1P8A moderate Biomarker [384]
SLAIN2 OTSM5QIO moderate Genetic Variation [144]
SOAT1 OTB4Y5RJ moderate Biomarker [385]
SUOX OTEJQ9FC moderate Genetic Variation [152]
TAB2 OTPZK76F moderate Genetic Variation [144]
TCTA OT0AH12O moderate Genetic Variation [350]
TMBIM1 OTE47B57 moderate Genetic Variation [144]
TMEM201 OTZBZ4MC moderate Biomarker [386]
TNFSF8 OTDYGDJ3 moderate Genetic Variation [271]
ACSBG1 OTM040MW Strong Biomarker [387]
APAF1 OTJWIVY0 Strong Genetic Variation [388]
ARF6 OTVV7KJO Strong Genetic Variation [389]
ARHGEF28 OT3F32IU Strong Genetic Variation [390]
ARHGEF6 OTN1ABGL Strong Biomarker [391]
ASAP1 OT4DLRYY Strong Biomarker [339]
ATF2 OTNIZPEA Strong Genetic Variation [392]
ATG16L2 OTJYU0W8 Strong Biomarker [393]
ATG5 OT4T5SMS Strong Genetic Variation [70]
ATP6V0A2 OTJBDX0Y Strong Biomarker [394]
AZIN2 OT8OB7CG Strong Biomarker [395]
BAZ1A OTWHOVZS Strong Genetic Variation [396]
BCKDHA OT0LHOZB Strong Biomarker [397]
BEST1 OTWHE1ZC Strong Biomarker [398]
BGLAP OTK1YLWQ Strong Biomarker [399]
BSN OTZ72VIB Strong Genetic Variation [70]
C4A OTXMOYXU Strong Genetic Variation [400]
CABIN1 OT4G5CIK Strong Biomarker [401]
CALCOCO2 OTRGX0OV Strong Genetic Variation [402]
CARD10 OT2RPM4I Strong Altered Expression [403]
CARD8 OTXXZYWU Strong Genetic Variation [262]
CARD9 OTJ81AWD Strong Biomarker [382]
CCAR1 OTUXLQZZ Strong Biomarker [404]
CCDC88B OTEDUI2J Strong Altered Expression [405]
CCL4L2 OTDBSXOU Strong Altered Expression [406]
CCL8 OTCTWYN8 Strong Altered Expression [406]
CD1C OT4XINUJ Strong Altered Expression [407]
CDCA5 OTZLCQ5U Strong Biomarker [185]
CDH13 OTD2CYM5 Strong Genetic Variation [72]
CEACAM8 OTLL9WWO Strong Altered Expression [408]
CERS1 OT6EYRM3 Strong Altered Expression [409]
CLDN2 OTRF3D6Y Strong Genetic Variation [410]
CLDN5 OTUX60YO Strong Altered Expression [411]
CLDN8 OT7IIWXG Strong Biomarker [412]
CLEC16A OTLGV5SV Strong Genetic Variation [70]
CLEC4D OTT7X1UC Strong Altered Expression [413]
COMP OTS2FPMI Strong Altered Expression [414]
CORIN OT4SK7DK Strong Biomarker [176]
CORO7 OTG7MEAJ Strong Biomarker [415]
CRNKL1 OTWBQNGU Strong Biomarker [176]
CRX OTH435SV Strong Genetic Variation [273]
CXCL5 OTZOUPCA Strong Altered Expression [416]
CYLD OT37FKH0 Strong Altered Expression [417]
DEF8 OTS93PPZ Strong Altered Expression [418]
DEFB104A OTLQZR6K Strong Biomarker [419]
DENND1B OT3VCNPE Strong Genetic Variation [72]
DLG1 OTCRZYWT Strong Genetic Variation [420]
DMBT1 OTVNU9D9 Strong Altered Expression [421]
DOCK11 OTFSTN6A Strong Biomarker [422]
DSC2 OTODVH8K Strong Biomarker [423]
DSG1 OT11HC3A Strong Biomarker [201]
DSG2 OTJPB2TO Strong Biomarker [423]
DSP OTB2MOP8 Strong Biomarker [201]
EIF2A OTWXELQP Strong Altered Expression [424]
EIF2B5 OTV3R4RB Strong Biomarker [425]
ELAVL3 OTI2VI8B Strong Biomarker [426]
EMSY OTBQ3KQE Strong Genetic Variation [427]
FCHSD2 OTKXLIJ6 Strong Genetic Variation [428]
FCN2 OTTHJBKZ Strong Biomarker [185]
FCRL3 OTIFXFWL Strong Biomarker [429]
FH OTEQWU6Q Strong Altered Expression [413]
FKBP11 OTY2GC67 Strong Altered Expression [430]
FLNB OTPCOYL6 Strong Genetic Variation [431]
FOXP2 OTVX6A59 Strong Genetic Variation [432]
FRG1 OTEJ8HSD Strong Genetic Variation [433]
FRG2 OTKIK5HR Strong Genetic Variation [433]
FUT2 OTLXM6WI Strong Biomarker [434]
GADL1 OTJM4A0R Strong Biomarker [395]
GCHFR OTEOT8GI Strong Biomarker [185]
GCKR OTSIWXGG Strong Genetic Variation [72]
GDF1 OTZ1VRBH Strong Altered Expression [409]
GNB4 OTC1GPHA Strong Biomarker [435]
GNG11 OTHIXBGW Strong Biomarker [435]
GOT2 OT6XBWN0 Strong Biomarker [436]
GP2 OTB6TMGY Strong Biomarker [437]
GPR68 OT1NXSMN Strong Biomarker [438]
GSDMA OT912R2E Strong Altered Expression [439]
GSDMB OTWA7P10 Strong Biomarker [440]
HAT1 OT307KEN Strong Altered Expression [164]
HEATR3 OTB52FZ4 Strong Genetic Variation [441]
HELB OT769EC5 Strong Biomarker [442]
HERC2 OTNQYKOB Strong Genetic Variation [443]
HLA-C OTV38BUJ Strong Biomarker [248]
HLA-DQB1 OTVVI3UI Strong Genetic Variation [271]
HLA-DRB3 OT5PM9N7 Strong Genetic Variation [444]
HLA-DRB5 OTUX5TWM Strong Genetic Variation [325]
HMG20A OTASVPIF Strong Biomarker [445]
HNRNPD OT5UO1FA Strong Genetic Variation [446]
HSF2 OTXNJIJ9 Strong Biomarker [447]
HSPA6 OTH4S7WB Strong Altered Expression [448]
IFNA10 OTO2FEXF Strong Genetic Variation [449]
IFNA4 OTII5O0G Strong Genetic Variation [449]
IFNGR1 OTCTQBWW Strong Genetic Variation [228]
IL17C OTKXIVNQ Strong Biomarker [450]
IL18BP OTW0LRYZ Strong Altered Expression [451]
IL1F10 OTJAASGC Strong Biomarker [452]
IL20RA OTSIVBVS Strong Biomarker [453]
IL34 OTZ15VVK Strong Altered Expression [454]
IL6R OTCQL07Z Strong Genetic Variation [455]
IMPACT OTQ923OB Strong Genetic Variation [456]
INSRR OT3F75WA Strong Biomarker [457]
IRF6 OTKJ44EV Strong Genetic Variation [72]
ITLN1 OT7ZLJVV Strong Genetic Variation [458]
KAT2A OTN0W2SW Strong Genetic Variation [223]
KIF21B OTFXFIU3 Strong Biomarker [459]
KPNA1 OTEMVAJ6 Strong Genetic Variation [460]
KRT1 OTIOJWA4 Strong Altered Expression [461]
KYAT3 OTO4U2QK Strong Altered Expression [164]
LAMB1 OT6J9LJR Strong Biomarker [462]
LDAH OTXRU9XQ Strong Biomarker [223]
LGALS4 OTKQCG0H Strong Altered Expression [312]
LORICRIN OTFRPVEO Strong Biomarker [404]
LRG1 OTLD0KWA Strong Altered Expression [463]
LXN OTZQ2M6Y Strong Biomarker [464]
MACROD2 OTNQCHC6 Strong Genetic Variation [432]
MAGI2 OTXDDKZS Strong Genetic Variation [465]
MAP1S OT5WUD4C Strong Biomarker [466]
MARCHF1 OTI2EYO6 Strong Biomarker [467]
MARCHF7 OTG9SF10 Strong Genetic Variation [468]
MARCO OT0NW2Q0 Strong Biomarker [469]
MARVELD2 OTKB96L5 Strong Biomarker [411]
MDFIC OTSRYBWZ Strong Biomarker [470]
MED13L OTSP1W0F Strong Biomarker [471]
MEFV OTRJ6S6K Strong Genetic Variation [472]
MEGF8 OT5G38CH Strong Biomarker [473]
MEPE OTXJRUW0 Strong Biomarker [474]
MGP OTZWU3FU Strong Biomarker [475]
MLN OTBZ5SE5 Strong Genetic Variation [428]
MORC4 OTJBEHNE Strong Genetic Variation [410]
MPZ OTAR2YXH Strong Biomarker [264]
MSC OTBRPZL5 Strong Biomarker [476]
MST1 OTOC4UNG Strong Biomarker [244]
MTFMT OT1OIVJL Strong Biomarker [470]
MTMR3 OTBIT23O Strong Biomarker [477]
MUC19 OTM06UGV Strong Genetic Variation [244]
MUC2 OT3X4QVX Strong Biomarker [366]
MUC3A OTI4XUDY Strong Altered Expression [112]
MYDGF OT9HRPL6 Strong Altered Expression [478]
MYLK3 OTC58V2Q Strong Biomarker [259]
MYO9B OTQ94R5K Strong Genetic Variation [479]
NCR2 OT2H13BX Strong Altered Expression [480]
NEURL1 OT2C4P70 Strong Biomarker [481]
NFKBIZ OTU728KS Strong Altered Expression [482]
NME6 OTJNKOFA Strong Altered Expression [418]
NPC1 OTRIPICX Strong Biomarker [483]
NR2C2 OTDZWVOJ Strong Altered Expression [255]
NSF OTKRJ2ZT Strong Biomarker [484]
NT5C3A OT67KZJA Strong Biomarker [185]
NUDT15 OTX8SZOT Strong Genetic Variation [485]
NXF1 OTEFHXG6 Strong Genetic Variation [431]
OR10A4 OTYYB8SY Strong Biomarker [486]
ORM2 OTRJGZP8 Strong Biomarker [487]
PAFAH1B1 OT9T2TCJ Strong Biomarker [488]
PANX1 OTXPEDOK Strong Altered Expression [489]
PANX2 OTAQ2S8R Strong Altered Expression [490]
PARM1 OTDNK7EX Strong Genetic Variation [491]
PER3 OTVKYVJA Strong Genetic Variation [445]
PGAP3 OTH9A75E Strong Altered Expression [439]
PGLYRP1 OTBTPR2T Strong Genetic Variation [492]
PGLYRP3 OT5C7PRT Strong Biomarker [492]
PGLYRP4 OTI115BR Strong Genetic Variation [492]
PHOX2B OT3SFR2O Strong Genetic Variation [493]
PIK3R3 OTXGJ8N1 Strong Biomarker [435]
PLB1 OTZ6TTYV Strong Genetic Variation [108]
PLCG2 OTGVC9MY Strong Genetic Variation [349]
PMP22 OTXWYWCZ Strong Biomarker [264]
PNN OT0HXICH Strong Biomarker [481]
POU5F1 OTDHHN7O Strong Biomarker [462]
PPP1R1A OTGTAGCV Strong Biomarker [494]
PRDM1 OTQLSVBS Strong Genetic Variation [70]
PRDM5 OTU1GB68 Strong Altered Expression [495]
PRDX6 OTS8KC8A Strong Altered Expression [496]
PROX1 OT68R6IO Strong Altered Expression [497]
PSMA7 OTPHI6ST Strong Altered Expression [498]
PSTPIP1 OT4PGEAB Strong Genetic Variation [499]
PTPRF OTH5KF2D Strong Biomarker [500]
PUS10 OTFFJWZX Strong Genetic Variation [72]
RAC2 OTAOHFNH Strong Biomarker [501]
RAP1A OT5RH6TI Strong Biomarker [330]
RBMXL1 OTMGCWWB Strong Altered Expression [164]
RBX1 OTYA1UIO Strong Genetic Variation [432]
RCL1 OT7O00YX Strong Biomarker [502]
RETN OTW5Z1NH Strong Biomarker [166]
RNASE2 OT8Z4FNE Strong Biomarker [503]
RNASET2 OTWY64L7 Strong Biomarker [504]
RSPO2 OT3HHXU0 Strong Biomarker [505]
RTRAF OTJ6NVMW Strong Biomarker [425]
SAP130 OT01SO0E Strong Biomarker [506]
SEC14L2 OTJST64D Strong Genetic Variation [431]
SEPHS1 OTZ19I59 Strong Genetic Variation [507]
SF3B3 OTAC9LZT Strong Biomarker [506]
SNX20 OTNL4B1S Strong Genetic Variation [245]
SUCLA2 OTMZD4PW Strong Biomarker [508]
TAGAP OTHJNNO2 Strong Genetic Variation [509]
TAP2 OTWSYFI7 Strong Biomarker [282]
TCF21 OT393IMA Strong Biomarker [415]
TCF7 OT1ID822 Strong Biomarker [510]
TCN2 OT41D0L3 Strong Genetic Variation [511]
TFF2 OTRXB19X Strong Biomarker [283]
THEMIS OTXODBXJ Strong Biomarker [512]
THY1 OTVONVTB Strong Biomarker [256]
TLR10 OTQ1KVJO Strong Genetic Variation [513]
TNFAIP6 OT1SLUZH Strong Biomarker [514]
TNFRSF6B OTKAN9G7 Strong Genetic Variation [245]
TOLLIP OTYEO4NR Strong Biomarker [242]
TRAF3 OT5TQBGV Strong Altered Expression [515]
TRAF4 OTJLRVMC Strong Biomarker [516]
TRAF5 OTSBTLO0 Strong Altered Expression [515]
TRAP1 OTNG0L8J Strong Biomarker [517]
TRIM22 OTJBLG5R Strong Biomarker [518]
TTLL5 OTUKOVEM Strong Biomarker [519]
ATG4A OTDHXAPG Definitive Genetic Variation [520]
CCL7 OTDIS99H Definitive Genetic Variation [521]
CCRL2 OT5PX0RX Definitive Biomarker [522]
CD300LF OTQWJGSR Definitive Genetic Variation [523]
CD3D OTRBLP0R Definitive Altered Expression [524]
CLEC10A OTD8HQT6 Definitive Biomarker [303]
CLEC2D OTVRLKPM Definitive Genetic Variation [303]
CLEC4A OTNLPK2C Definitive Biomarker [303]
DYM OTQ670WI Definitive Genetic Variation [525]
ELMO1 OTY2ORXK Definitive Genetic Variation [526]
FBLN5 OTLVNZ8U Definitive Biomarker [527]
FCRL4 OT3DVTRV Definitive Biomarker [257]
FDCSP OT8KGE9M Definitive Altered Expression [524]
GALNT2 OTZZ5386 Definitive Altered Expression [528]
HLA-DRA OT7KZMP2 Definitive Genetic Variation [333]
IER3 OTZJI5FZ Definitive Biomarker [529]
IL17RA OTVVI8ER Definitive Genetic Variation [530]
ISX OTULQRWA Definitive Biomarker [231]
KIF3A OTMUBSSK Definitive Biomarker [531]
LPIN2 OTRRTMXX Definitive Biomarker [532]
MAGT1 OTQSAV5C Definitive Altered Expression [169]
MPRIP OT5FV5NS Definitive Altered Expression [533]
NAT9 OT4ZKCRS Definitive Genetic Variation [523]
NFIL3 OTQH9HM3 Definitive Altered Expression [534]
NLRP11 OTAL4ADW Definitive Genetic Variation [535]
PSMG1 OTZ5I6UM Definitive Genetic Variation [333]
RABGEF1 OTWC3Z3R Definitive Biomarker [536]
RAVER2 OT0MDL7K Definitive Genetic Variation [537]
REEP6 OTY4FPO8 Definitive Genetic Variation [538]
REG1B OTSC2133 Definitive Biomarker [257]
RNF138 OTPU0CO4 Definitive Biomarker [539]
SHC1 OT1J5IRN Definitive Biomarker [299]
SMAD5 OTQNSVCQ Definitive Altered Expression [540]
STEAP3 OTS9GZK5 Definitive Altered Expression [539]
TAC4 OTYWPPM3 Definitive Altered Expression [541]
TERF2IP OT3M5P3G Definitive Biomarker [536]
TLE1 OT50MRZ1 Definitive Genetic Variation [528]
TMEM183A OT1VBS2L Definitive Biomarker [231]
TRAIP OTMPT9Y2 Definitive Genetic Variation [542]
------------------------------------------------------------------------------------
⏷ Show the Full List of 409 DOT(s)

References

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72 Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760. Epub 2017 Jan 9.
73 Diagnostic Potential of Systemic Eosinophil-Associated Cytokines and Growth Factors in IBD.Gastroenterol Res Pract. 2018 Jul 29;2018:7265812. doi: 10.1155/2018/7265812. eCollection 2018.
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80 Dipeptidyl Peptidase-4 Inhibitors and Inflammatory Bowel Disease Risk: A Meta-analysis.Ann Pharmacother. 2019 Jul;53(7):697-704. doi: 10.1177/1060028019827852. Epub 2019 Jan 30.
81 Modulation of CD39 and Exogenous APT102 Correct Immune Dysfunction in Experimental Colitis and Crohn's Disease.J Crohns Colitis. 2020 Jul 9;14(6):818-830. doi: 10.1093/ecco-jcc/jjz182.
82 Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.J Gastroenterol Hepatol. 2006 Sep;21(9):1407-11. doi: 10.1111/j.1440-1746.2006.04319.x.
83 IL-23 in inflammatory bowel diseases and colon cancer.Cytokine Growth Factor Rev. 2019 Feb;45:1-8. doi: 10.1016/j.cytogfr.2018.12.002. Epub 2018 Dec 12.
84 CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease.J Crohns Colitis. 2018 Apr 27;12(5):589-599. doi: 10.1093/ecco-jcc/jjx185.
85 Mucosal Healing and Bacterial Composition in Response to Enteral Nutrition Vs Steroid-based Induction Therapy-A Randomised Prospective Clinical Trial in Children With Crohn's Disease.J Crohns Colitis. 2019 Jul 25;13(7):846-855. doi: 10.1093/ecco-jcc/jjy207.
86 The Safety, Tolerability, and Pharmacokinetics Profile of BT-11, an Oral, Gut-Restricted Lanthionine Synthetase C-Like 2 Agonist Investigational New Drug for Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Phase I Clinical Trial.Inflamm Bowel Dis. 2020 Mar 4;26(4):643-652. doi: 10.1093/ibd/izz094.
87 A population- and family-based study of Canadian families reveals association of HLA DRB1*0103 with colonic involvement in inflammatory bowel disease.Inflamm Bowel Dis. 2003 Jan;9(1):1-9. doi: 10.1097/00054725-200301000-00001.
88 Changes in serum hepcidin levels in children with inflammatory bowel disease during anti-inflammatory treatment.J Paediatr Child Health. 2020 Feb;56(2):276-282. doi: 10.1111/jpc.14593. Epub 2019 Aug 14.
89 Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study.World J Gastroenterol. 2017 Oct 21;23(39):7139-7149. doi: 10.3748/wjg.v23.i39.7139.
90 HLA-G is expressed in intestinal samples of ulcerative colitis and Crohn's disease patients and HLA-G5 expression is differentially correlated with TNF and IL-10 cytokine expression.Hum Immunol. 2018 Jun;79(6):477-484. doi: 10.1016/j.humimm.2018.03.006. Epub 2018 Mar 26.
91 Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease.Inflamm Bowel Dis. 2017 Oct;23(10):1718-1729. doi: 10.1097/MIB.0000000000001246.
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144 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359. Epub 2015 Jul 20.
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146 Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease.PLoS One. 2013 Oct 10;8(10):e76969. doi: 10.1371/journal.pone.0076969. eCollection 2013.
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153 Altered pattern of tumor necrosis factor-alpha production in peripheral blood monocytes from Crohn's disease.World J Gastroenterol. 2016 Nov 7;22(41):9117-9126. doi: 10.3748/wjg.v22.i41.9117.
154 Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis.Inflamm Bowel Dis. 2005 Jan;11(1):16-23. doi: 10.1097/00054725-200501000-00003.
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156 Increases in IGF-1 After Anti-TNF- Therapy Are Associated With Bone and Muscle Accrual in Pediatric Crohn Disease.J Clin Endocrinol Metab. 2018 Mar 1;103(3):936-945. doi: 10.1210/jc.2017-01916.
157 Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.Front Immunol. 2017 Dec 11;8:1531. doi: 10.3389/fimmu.2017.01531. eCollection 2017.
158 Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population.J Hum Genet. 2015 Sep;60(9):525-31. doi: 10.1038/jhg.2015.59. Epub 2015 Jun 18.
159 NLRP1 haplotypes associated with leprosy in Brazilian patients.Infect Genet Evol. 2013 Oct;19:274-9. doi: 10.1016/j.meegid.2013.06.006. Epub 2013 Jun 13.
160 CD73 expression in tissue granulomas in distinguishing intestinal tuberculosis from Crohn's disease in a South African cohort.Scand J Gastroenterol. 2018 Oct-Nov;53(10-11):1217-1221. doi: 10.1080/00365521.2018.1503326. Epub 2018 Oct 8.
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162 Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease.Gut Liver. 2019 Jan 15;13(1):62-66. doi: 10.5009/gnl18261.
163 Effect of Oral Nutrition Supplements and TGF-2 on Nutrition and Inflammatory Patterns in Patients With Active Crohn's Disease.Nutr Clin Pract. 2020 Oct;35(5):885-893. doi: 10.1002/ncp.10448. Epub 2019 Dec 15.
164 Increased expression of kynurenine aminotransferases mRNA in lymphocytes of patients with inflammatory bowel disease.Therap Adv Gastroenterol. 2019 Oct 19;12:1756284819881304. doi: 10.1177/1756284819881304. eCollection 2019.
165 The Adipokine Metrnl Ameliorates Chronic Colitis in Il-10-/- Mice by Attenuating Mesenteric Adipose Tissue Lesions During Spontaneous Colitis.J Crohns Colitis. 2019 Jul 25;13(7):931-941. doi: 10.1093/ecco-jcc/jjz001.
166 Hyperadiponectinemia During Infliximab Induction Therapy in Pediatric Crohn Disease.J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):915-919. doi: 10.1097/MPG.0000000000001876.
167 Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.EMBO Mol Med. 2019 Jun;11(6):e10120. doi: 10.15252/emmm.201810120.
168 Association of Crohn's Disease with Aryl Hydrocarbon Receptor Gene Polymorphisms in Patients from Southeast China.Immunol Invest. 2019 Nov;48(8):809-821. doi: 10.1080/08820139.2019.1569677. Epub 2019 Aug 13.
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173 MicroRNA-143 Targets ATG2B to Inhibit Autophagy and Increase Inflammatory Responses in Crohn's Disease.Inflamm Bowel Dis. 2018 Mar 19;24(4):781-791. doi: 10.1093/ibd/izx075.
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180 Mutation-Induced Functional Alterations of CCR6.J Pharmacol Exp Ther. 2017 Jan;360(1):106-116. doi: 10.1124/jpet.116.237669. Epub 2016 Oct 27.
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182 Serotonin 5-HT7 receptor is critically involved in acute and chronic inflammation of the gastrointestinal tract.Inflamm Bowel Dis. 2014 Sep;20(9):1516-29. doi: 10.1097/MIB.0000000000000150.
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219 Comprehensive bioinformatics analyses of Crohn's disease.Mol Med Rep. 2017 Apr;15(4):2267-2272. doi: 10.3892/mmr.2017.6250. Epub 2017 Feb 28.
220 Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease.Inflamm Bowel Dis. 2017 Oct;23(10):1752-1761. doi: 10.1097/MIB.0000000000001264.
221 Unique -Glucuronidase Locus in Gut Microbiomes of Crohn's Disease Patients and Unaffected First-Degree Relatives.PLoS One. 2016 Jan 29;11(1):e0148291. doi: 10.1371/journal.pone.0148291. eCollection 2016.
222 Vitamin D Status Is Associated with Hepcidin and Hemoglobin Concentrations in Children with Inflammatory Bowel Disease.Inflamm Bowel Dis. 2017 Sep;23(9):1650-1658. doi: 10.1097/MIB.0000000000001178.
223 Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.Gastroenterology. 2015 Nov;149(6):1575-1586. doi: 10.1053/j.gastro.2015.07.065. Epub 2015 Aug 14.
224 Epigenetic modification of intestinal smooth muscle cell phenotype during proliferation.Am J Physiol Cell Physiol. 2018 Nov 1;315(5):C722-C733. doi: 10.1152/ajpcell.00216.2018. Epub 2018 Aug 15.
225 Serum Glycoproteome Profiles for Distinguishing Intestinal Fibrosis from Inflammation in Crohn's Disease.PLoS One. 2017 Jan 23;12(1):e0170506. doi: 10.1371/journal.pone.0170506. eCollection 2017.
226 An international study of the quality of life of adult patients treated with home parenteral nutrition.Clin Nutr. 2019 Aug;38(4):1788-1796. doi: 10.1016/j.clnu.2018.07.024. Epub 2018 Aug 6.
227 IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.PLoS One. 2014 Dec 26;9(12):e115848. doi: 10.1371/journal.pone.0115848. eCollection 2014.
228 Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy.Pharmacogenomics J. 2018 Jan;18(1):87-97. doi: 10.1038/tpj.2016.84. Epub 2017 Jan 31.
229 IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis. 2013 Jan;19(1):115-23. doi: 10.1002/ibd.22974.
230 A polymorphism in the IL11 gene is associated with ulcerative colitis.Genes Immun. 2002 Dec;3(8):494-6. doi: 10.1038/sj.gene.6363897.
231 SNP-SNP interactions discovered by logic regression explain Crohn's disease genetics.PLoS One. 2012;7(10):e43035. doi: 10.1371/journal.pone.0043035. Epub 2012 Oct 12.
232 The role of interleukin-13 in chronic inflammatory intestinal disorders.Autoimmun Rev. 2019 May;18(5):549-555. doi: 10.1016/j.autrev.2019.03.012. Epub 2019 Mar 4.
233 Interleukin-15 receptor expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab.Immunology. 2013 Jan;138(1):47-56. doi: 10.1111/imm.12014.
234 The -295T-to-C promoter polymorphism of the IL-16 gene is associated with Crohn's disease.Clin Immunol. 2003 Mar;106(3):197-200. doi: 10.1016/s1521-6616(03)00021-4.
235 Role of IL-1ra and Granzyme B as biomarkers in active Crohn's disease patients.Biomarkers. 2018 Mar;23(2):161-166. doi: 10.1080/1354750X.2017.1387933. Epub 2017 Oct 16.
236 Evaluating IL-21 as a Potential Therapeutic Target in Crohn's Disease.Gastroenterol Res Pract. 2018 Apr 10;2018:5962624. doi: 10.1155/2018/5962624. eCollection 2018.
237 Expression of interleukin (IL)-19 and IL-24 in inflammatory bowel disease patients: a cross-sectional study.Clin Exp Immunol. 2014 Jul;177(1):64-75. doi: 10.1111/cei.12285.
238 Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis.Mucosal Immunol. 2019 May;12(3):632-643. doi: 10.1038/s41385-019-0138-4. Epub 2019 Feb 11.
239 Suleiman AA, Khatri A, Minocha M, Othman AA: Population Pharmacokinetics of the Interleukin-23 Inhibitor Risankizumab in Subjects with Psoriasis and Crohn's Disease: Analyses of Phase I and II Trials. Clin Pharmacokinet. 2019 Mar;58(3):375-387. doi: 10.1007/s40262-018-0704-z.
240 Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-Only Crohn's Disease in Treatment-Naive Pediatric Patients.Gastroenterology. 2017 May;152(6):1345-1357.e7. doi: 10.1053/j.gastro.2017.01.016. Epub 2017 Jan 26.
241 IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.J Clin Invest. 2019 Apr 2;129(5):1910-1925. doi: 10.1172/JCI121668. eCollection 2019 Apr 2.
242 Differential expression of key regulators of Toll-like receptors in ulcerative colitis and Crohn's disease: a role for Tollip and peroxisome proliferator-activated receptor gamma?.Clin Exp Immunol. 2016 Mar;183(3):358-68. doi: 10.1111/cei.12732. Epub 2015 Nov 26.
243 Dissecting the genetics of complex inheritance: linkage disequilibrium mapping provides insight into Crohn disease.Am J Hum Genet. 2011 Dec 9;89(6):798-805. doi: 10.1016/j.ajhg.2011.11.006.
244 A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese population.J Cell Mol Med. 2018 Apr;22(4):2368-2377. doi: 10.1111/jcmm.13530. Epub 2018 Feb 14.
245 Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.Gastroenterology. 2017 Jan;152(1):206-217.e2. doi: 10.1053/j.gastro.2016.09.032. Epub 2016 Sep 28.
246 Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn's disease.Hum Immunol. 2016 Jan;77(1):104-109. doi: 10.1016/j.humimm.2015.10.020. Epub 2015 Nov 2.
247 Activating Killer-cell Immunoglobulin-like Receptor genes confer risk for Crohn's disease in children and adults of the Western European descent: Findings based on case-control studies.PLoS One. 2019 Jun 13;14(6):e0217767. doi: 10.1371/journal.pone.0217767. eCollection 2019.
248 HLA-C*01 is a Risk Factor for Crohn's Disease.Inflamm Bowel Dis. 2016 Apr;22(4):796-806. doi: 10.1097/MIB.0000000000000693.
249 Serum lipopolysaccharide-binding protein and soluble CD14 are markers of disease activity in patients with Crohn's disease.Inflamm Bowel Dis. 2011 Mar;17(3):767-77. doi: 10.1002/ibd.21402. Epub 2010 Sep 23.
250 Ulcer-associated cell lineage expresses genes involved in regeneration and is hallmarked by high neutrophil gelatinase-associated lipocalin (NGAL) levels.J Pathol. 2019 Jul;248(3):316-325. doi: 10.1002/path.5258. Epub 2019 Mar 19.
251 Joint analysis of individual-level and summary-level GWAS data by leveraging pleiotropy.Bioinformatics. 2019 May 15;35(10):1729-1736. doi: 10.1093/bioinformatics/bty870.
252 Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner.Sci Transl Med. 2019 Sep 25;11(511):eaas9292. doi: 10.1126/scitranslmed.aas9292.
253 Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G95-G105. doi: 10.1152/ajpgi.00196.2018. Epub 2018 Oct 18.
254 Associations between functional polymorphisms in the NFB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease.Pharmacogenomics J. 2014 Dec;14(6):526-34. doi: 10.1038/tpj.2014.19. Epub 2014 Apr 29.
255 TAK1 is a key modulator of the profibrogenic phenotype of human ileal myofibroblasts in Crohn's disease.Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G443-54. doi: 10.1152/ajpgi.00400.2014. Epub 2015 Jul 16.
256 Matrix metalloproteinases cleave membrane-bound PD-L1 on CD90+ (myo-)fibroblasts in Crohn's disease and regulate Th1/Th17 cell responses.Int Immunol. 2020 Jan 9;32(1):57-68. doi: 10.1093/intimm/dxz060.
257 Characterization of intestinal gene expression profiles in Crohn's disease by genome-wide microarray analysis.Inflamm Bowel Dis. 2010 Oct;16(10):1717-28. doi: 10.1002/ibd.21263.
258 Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.Genes Immun. 2009 Oct;10(7):631-5. doi: 10.1038/gene.2009.56. Epub 2009 Aug 6.
259 Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn's disease.Biomed Pharmacother. 2019 Oct;118:109149. doi: 10.1016/j.biopha.2019.109149. Epub 2019 Jul 12.
260 NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults.Inflamm Bowel Dis. 2012 Mar;18(3):529-35. doi: 10.1002/ibd.21708. Epub 2011 Apr 6.
261 High-throughput characterization of genetic effects on DNA-protein binding and gene transcription.Genome Res. 2018 Nov;28(11):1701-1708. doi: 10.1101/gr.237354.118. Epub 2018 Sep 25.
262 Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease. J Clin Invest. 2018 May 1;128(5):1793-1806. doi: 10.1172/JCI98642. Epub 2018 Mar 26.
263 Validating inflammatory bowel disease (IBD) in the Swedish National Patient Register and the Swedish Quality Register for IBD (SWIBREG).Scand J Gastroenterol. 2017 Feb;52(2):216-221. doi: 10.1080/00365521.2016.1246605. Epub 2016 Oct 31.
264 Evaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease.Pharmacol Rep. 2017 Jun;69(3):386-392. doi: 10.1016/j.pharep.2017.01.003. Epub 2017 Jan 12.
265 Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.PLoS One. 2011;6(7):e22978. doi: 10.1371/journal.pone.0022978. Epub 2011 Jul 29.
266 Vitamin D metabolites are lower with active Crohn's disease and spontaneously recover with development of remission.Therap Adv Gastroenterol. 2019 Jul 26;12:1756284819865144. doi: 10.1177/1756284819865144. eCollection 2019.
267 Crohn's disease is facilitated by a disturbance of programmed death-1 ligand 2 on blood dendritic cells.Clin Transl Immunology. 2019 Jul 25;8(7):e01071. doi: 10.1002/cti2.1071. eCollection 2019.
268 Expression of group XIIA phospholipase A2 in human digestive organs.APMIS. 2014 Dec;122(12):1171-7. doi: 10.1111/apm.12280. Epub 2014 May 26.
269 Dietary n? polyunsaturated fatty acids ameliorate Crohn's disease in rats by modulating the expression of PPAR?NFAT.Mol Med Rep. 2017 Dec;16(6):8315-8322. doi: 10.3892/mmr.2017.7673. Epub 2017 Sep 29.
270 Missense mutation in PRKCQ is associated with Crohn's disease.J Dig Dis. 2019 May;20(5):243-247. doi: 10.1111/1751-2980.12717. Epub 2019 Apr 23.
271 A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.Gastroenterology. 2013 Apr;144(4):781-8. doi: 10.1053/j.gastro.2012.12.021. Epub 2012 Dec 22.
272 Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis.Front Cell Infect Microbiol. 2018 Jan 25;8:11. doi: 10.3389/fcimb.2018.00011. eCollection 2018.
273 High Adherence to Surveillance Guidelines in Inflammatory Bowel Disease Patients Results in Low Colorectal Cancer and Dysplasia Rates, While Rates of Dysplasia are Low Before the Suggested Onset of Surveillance.J Crohns Colitis. 2019 Sep 27;13(10):1343-1350. doi: 10.1093/ecco-jcc/jjz066.
274 Polymorphism in ICAM-1, PECAM-1, E-selectin, and L-selectin genes in Tunisian patients with inflammatory bowel disease.Eur J Gastroenterol Hepatol. 2009 Feb;21(2):167-75. doi: 10.1097/MEG.0b013e32830e6fc8.
275 ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides.Gastroenterology. 2019 Mar;156(4):1098-1111. doi: 10.1053/j.gastro.2018.11.033. Epub 2018 Nov 16.
276 Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.Int J Colorectal Dis. 2012 Jan;27(1):11-9. doi: 10.1007/s00384-011-1265-x. Epub 2011 Jun 25.
277 Polymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease.Am J Clin Nutr. 2014 Feb;99(2):378-83. doi: 10.3945/ajcn.113.068015. Epub 2013 Nov 27.
278 SLCO3A1, A novel crohn's disease-associated gene, regulates nf-B activity and associates with intestinal perforation.PLoS One. 2014 Jun 19;9(6):e100515. doi: 10.1371/journal.pone.0100515. eCollection 2014.
279 Time-to-reach Target Calprotectin Level in Newly Diagnosed Patients With Inflammatory Bowel Disease.J Pediatr Gastroenterol Nutr. 2019 Oct;69(4):466-473. doi: 10.1097/MPG.0000000000002458.
280 Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis.J Biol Chem. 2017 Jun 30;292(26):10801-10812. doi: 10.1074/jbc.M116.771469. Epub 2017 May 10.
281 Succinate receptor mediates intestinal inflammation and fibrosis.Mucosal Immunol. 2019 Jan;12(1):178-187. doi: 10.1038/s41385-018-0087-3. Epub 2018 Oct 2.
282 Difference in Pathomechanism Between Crohn's Disease and Ulcerative Colitis Revealed by Colon Transcriptome.Inflamm Bowel Dis. 2019 Mar 14;25(4):722-731. doi: 10.1093/ibd/izy359.
283 A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3).PLoS One. 2013 May 15;8(5):e64441. doi: 10.1371/journal.pone.0064441. Print 2013.
284 Erythrocyte transketolase deficiency in patients suffering from Crohn's disease.Eur Rev Med Pharmacol Sci. 2019 Oct;23(19):8501-8505. doi: 10.26355/eurrev_201910_19163.
285 Importance of TLR9-IL23-IL17 axis in inflammatory bowel disease development: Gene expression profiling study.Clin Immunol. 2018 Dec;197:86-95. doi: 10.1016/j.clim.2018.09.001. Epub 2018 Sep 5.
286 MicroRNA23a Overexpression in Crohn's Disease Targets Tumour Necrosis Factor Alpha Inhibitor Protein 3, Increasing Sensitivity to TNF and Modifying the Epithelial Barrier.J Crohns Colitis. 2020 Mar 13;14(3):381-392. doi: 10.1093/ecco-jcc/jjz145.
287 Herbs-partitioned moxibustion alleviates aberrant intestinal epithelial cell apoptosis by upregulating A20 expression in a mouse model of Crohn's disease.World J Gastroenterol. 2019 May 7;25(17):2071-2085. doi: 10.3748/wjg.v25.i17.2071.
288 Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn's Disease-Like Ileitis.Front Immunol. 2018 Mar 1;9:362. doi: 10.3389/fimmu.2018.00362. eCollection 2018.
289 Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.Med Sci Monit. 2016 Dec 7;22:4794-4802. doi: 10.12659/msm.902274.
290 Insight into the role of TSLP in inflammatory bowel diseases.Autoimmun Rev. 2017 Jan;16(1):55-63. doi: 10.1016/j.autrev.2016.09.014. Epub 2016 Oct 1.
291 The relationship between serum bilirubin and Crohn's disease.Inflamm Bowel Dis. 2014 Mar;20(3):481-7. doi: 10.1097/01.MIB.0000440817.84251.98.
292 Alterations in microRNA expression profiles in inflamed and noninflamed ascending colon mucosae of patients with active Crohn's disease.J Gastroenterol Hepatol. 2017 Oct;32(10):1706-1715. doi: 10.1111/jgh.13778.
293 Association of ZAP70 and PTPN6, but Not BANK1 or CLEC2D, with inflammatory bowel disease in the Tunisian population.Genet Test Mol Biomarkers. 2013 Apr;17(4):321-6. doi: 10.1089/gtmb.2012.0372. Epub 2013 Feb 13.
294 New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC.Inflamm Bowel Dis. 2009 Jul;15(7):971-84. doi: 10.1002/ibd.20893.
295 Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn's disease.Scand J Gastroenterol. 2009;44(10):1207-12. doi: 10.1080/00365520903171250.
296 Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies.Clin Exp Immunol. 2010 Nov;162(2):337-47. doi: 10.1111/j.1365-2249.2010.04248.x.
297 In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway.BMC Microbiol. 2012 Jun 13;12:107. doi: 10.1186/1471-2180-12-107.
298 Blood-based biomarkers can differentiate ulcerative colitis from Crohn's disease and noninflammatory diarrhea.Inflamm Bowel Dis. 2011 Aug;17(8):1719-25. doi: 10.1002/ibd.21574. Epub 2011 Jan 6.
299 Prioritizing candidate disease genes by network-based boosting of genome-wide association data.Genome Res. 2011 Jul;21(7):1109-21. doi: 10.1101/gr.118992.110. Epub 2011 May 2.
300 Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.Am J Gastroenterol. 2008 Mar;103(3):615-20. doi: 10.1111/j.1572-0241.2007.01661.x. Epub 2007 Nov 28.
301 KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population.Am J Gastroenterol. 2010 Oct;105(10):2209-17. doi: 10.1038/ajg.2010.161. Epub 2010 Apr 20.
302 Genes involved in the metabolism of poly-unsaturated fatty-acids (PUFA) and risk for Crohn's disease in children & young adults.PLoS One. 2010 Dec 20;5(12):e15672. doi: 10.1371/journal.pone.0015672.
303 Single nucleotide polymorphisms in C-type lectin genes, clustered in the IBD2 and IBD6 susceptibility loci, may play a role in the pathogenesis of inflammatory bowel diseases.Eur J Gastroenterol Hepatol. 2012 Aug;24(8):965-70. doi: 10.1097/MEG.0b013e328354f3d5.
304 Altered expression of CDX-2, PDX-1 and mucin core proteins in "Ulcer-associated cell lineage (UACL)" in Crohn's disease.J Mol Histol. 2008 Apr;39(2):161-8. doi: 10.1007/s10735-007-9149-7. Epub 2007 Oct 24.
305 Expression of catalytic proteasome subunits in the gut of patients with Crohn's disease.Int J Colorectal Dis. 2009 Oct;24(10):1133-9. doi: 10.1007/s00384-009-0679-1. Epub 2009 Mar 10.
306 Activation of the receptor NKG2D leads to production of Th17 cytokines in CD4+ T cells of patients with Crohn's disease.Gastroenterology. 2011 Jul;141(1):217-26, 226.e1-2. doi: 10.1053/j.gastro.2011.03.061. Epub 2011 Apr 7.
307 Real-time PCR quantification analysis of five mucosal transcripts in patients with Crohn's disease.Eur J Gastroenterol Hepatol. 2008 Apr;20(4):290-6. doi: 10.1097/MEG.0b013e3282f3557c.
308 Association of Toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2.Genes Immun. 2011 Dec;12(8):635-42. doi: 10.1038/gene.2011.41. Epub 2011 Jun 30.
309 SLC39A8 missense variant is associated with Crohn's disease but does not have a major impact on gut microbiome composition in healthy subjects.PLoS One. 2019 Jan 31;14(1):e0211328. doi: 10.1371/journal.pone.0211328. eCollection 2019.
310 Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties.J Gastroenterol. 2018 Sep;53(9):1035-1047. doi: 10.1007/s00535-018-1437-3. Epub 2018 Jan 27.
311 Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease.Gastroenterology. 2016 Aug;151(2):278-287.e6. doi: 10.1053/j.gastro.2016.04.001. Epub 2016 Apr 8.
312 Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function.FASEB J. 2016 Feb;30(2):544-54. doi: 10.1096/fj.15-272773. Epub 2015 Oct 19.
313 Significance of the genetic polymorphism of CYP2D6 and NAT2 in patients with inflammatory bowel diseases.Pharmacol Rep. 2014 Aug;66(4):686-90. doi: 10.1016/j.pharep.2014.04.002. Epub 2014 Apr 19.
314 Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn's disease.PLoS One. 2017 Dec 5;12(12):e0188925. doi: 10.1371/journal.pone.0188925. eCollection 2017.
315 Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene.World J Gastroenterol. 2005 Aug 21;11(31):4833-7. doi: 10.3748/wjg.v11.i31.4833.
316 Paraoxonases are associated with intestinal inflammatory diseases and intracellularly localized to the endoplasmic reticulum.Free Radic Biol Med. 2007 Sep 1;43(5):730-9. doi: 10.1016/j.freeradbiomed.2007.05.003. Epub 2007 May 10.
317 Immunosuppressed Patients with Crohn's Disease Are at Increased Risk of Postoperative Complications: Results from the ACS-NSQIP Database.J Gastrointest Surg. 2019 Jun;23(6):1188-1197. doi: 10.1007/s11605-019-04186-0. Epub 2019 Mar 18.
318 Polymorphism in the retinoic acid metabolizing enzyme CYP26B1 and the development of Crohn's Disease.PLoS One. 2013 Aug 19;8(8):e72739. doi: 10.1371/journal.pone.0072739. eCollection 2013.
319 Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.Gastroenterology. 2014 Apr;146(4):929-31. doi: 10.1053/j.gastro.2013.12.034. Epub 2014 Jan 7.
320 The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A.J Immunol. 2012 Aug 15;189(4):1946-54. doi: 10.4049/jimmunol.1201064. Epub 2012 Jul 9.
321 Common polymorphisms in the microsomal epoxide hydrolase and N-acetyltransferase 2 genes in association with inflammatory bowel disease in the Danish population.Eur J Gastroenterol Hepatol. 2011 Mar;23(3):269-74. doi: 10.1097/MEG.0b013e3283438a44.
322 The role of fatty acid hydrolase gene variants in inflammatory bowel disease.Aliment Pharmacol Ther. 2009 Mar 1;29(5):542-51. doi: 10.1111/j.1365-2036.2008.03910.x. Epub 2008 Dec 2.
323 Remission of Inflammatory Bowel Disease in Glucose-6-Phosphatase 3 Deficiency by Allogeneic Haematopoietic Stem Cell Transplantation.J Crohns Colitis. 2020 Jan 1;14(1):142-147. doi: 10.1093/ecco-jcc/jjz112.
324 Inverse expression of prostaglandin E2-related enzymes highlights differences between diverticulitis and inflammatory bowel disease.Dig Dis Sci. 2015 May;60(5):1236-46. doi: 10.1007/s10620-014-3478-7. Epub 2015 Feb 11.
325 Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.JAMA Neurol. 2016 Jun 1;73(6):691-7. doi: 10.1001/jamaneurol.2016.0150.
326 Systematic review with meta-analysis: real-world effectiveness and safety of vedolizumab in patients with inflammatory bowel disease.J Gastroenterol. 2018 Sep;53(9):1048-1064. doi: 10.1007/s00535-018-1480-0. Epub 2018 Jun 4.
327 Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.Eur J Hum Genet. 2007 Mar;15(3):328-35. doi: 10.1038/sj.ejhg.5201756. Epub 2007 Jan 10.
328 Neutralization of IL-1 ameliorates Crohn's disease-like ileitis by functional alterations of the gut microbiome.Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26717-26726. doi: 10.1073/pnas.1915043116. Epub 2019 Dec 16.
329 A BACH2 Gene Variant Is Associated with Postoperative Recurrence of Crohn's Disease.J Am Coll Surg. 2018 May;226(5):902-908. doi: 10.1016/j.jamcollsurg.2018.01.052. Epub 2018 Feb 13.
330 A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals.J Crohns Colitis. 2019 Apr 26;13(5):648-658. doi: 10.1093/ecco-jcc/jjy197.
331 Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease.J Clin Pathol. 2005 Oct;58(10):1057-63. doi: 10.1136/jcp.2004.024828.
332 CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease.Gastroenterology. 2001 Aug;121(2):246-54. doi: 10.1053/gast.2001.27154.
333 Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.Inflamm Bowel Dis. 2011 Sep;17(9):1936-42. doi: 10.1002/ibd.21579. Epub 2010 Dec 10.
334 Treatment sequence network meta-analysis in Crohn's disease: a methodological case study.Curr Med Res Opin. 2019 May;35(5):733-756. doi: 10.1080/03007995.2019.1580094. Epub 2019 Mar 20.
335 Novel immunoassays for detection of CUZD1 autoantibodies in serum of patients with inflammatory bowel diseases.Clin Chem Lab Med. 2017 Aug 28;55(10):1574-1581. doi: 10.1515/cclm-2016-1120.
336 CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue.Eur J Immunol. 2004 Jul;34(7):1992-2000. doi: 10.1002/eji.200324807.
337 Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1.Inflamm Bowel Dis. 2004 May;10(3):173-81. doi: 10.1097/00054725-200405000-00001.
338 A specific gene-microbe interaction drives the development of Crohn's disease-like colitis in mice.Sci Immunol. 2019 Apr 19;4(34):eaaw4341. doi: 10.1126/sciimmunol.aaw4341.
339 Alpha-defensins (-Defs) in Crohn's disease: decrease of ileal -Def 5 via permanent methylation and increase in plasma -Def 1-3 concentrations offering biomarker utility.Clin Exp Immunol. 2018 Apr;192(1):120-128. doi: 10.1111/cei.13085. Epub 2018 Jan 10.
340 Gastric medullary carcinoma, a distinct entity associated with microsatellite instability-H, prominent intraepithelial lymphocytes and improved prognosis.Histopathology. 2004 Nov;45(5):485-92. doi: 10.1111/j.1365-2559.2004.01998.x.
341 Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro.World J Gastroenterol. 2005 Jul 14;11(26):4024-31. doi: 10.3748/wjg.v11.i26.4024.
342 Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants.Blood. 1999 Mar 1;93(5):1684-96.
343 The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function.Immunogenetics. 2000 Nov;52(1-2):112-20. doi: 10.1007/s002510000259.
344 IL26 modulates cytokine response and anti-TNF consumption in Crohn's disease patients with bacterial DNA.J Mol Med (Berl). 2017 Nov;95(11):1227-1236. doi: 10.1007/s00109-017-1585-6. Epub 2017 Sep 6.
345 Evaluation of interleukin-6 and its soluble receptor components sIL-6R and sgp130 as markers of inflammation in inflammatory bowel diseases.Int J Colorectal Dis. 2018 Jul;33(7):927-936. doi: 10.1007/s00384-018-3069-8. Epub 2018 May 11.
346 Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn's Disease Patients.Digestion. 2019;99(3):194-204. doi: 10.1159/000490890. Epub 2018 Oct 19.
347 Allele frequency of inosine triphosphate pyrophosphatase (ITPA) and thiopurine-S-methyl transferase (TPMT) genes in the Tunisian population.Clin Res Hepatol Gastroenterol. 2012 Apr;36(2):178-84. doi: 10.1016/j.clinre.2011.12.001. Epub 2012 Jan 4.
348 Phospholipase A2 gene expression and activity in histologically normal ileal mucosa and in Crohn's ileitis.Gut. 1995 Sep;37(3):380-5. doi: 10.1136/gut.37.3.380.
349 Using genes to triangulate the pathophysiology of granulomatous autoinflammatory disease: NOD2, PLCG2 and LACC1.Int Immunol. 2018 Apr 25;30(5):205-213. doi: 10.1093/intimm/dxy021.
350 Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.Nat Genet. 2008 Aug;40(8):955-62. doi: 10.1038/ng.175. Epub 2008 Jun 29.
351 NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8(+) T cell migration.Exp Mol Pathol. 2017 Aug;103(1):56-70. doi: 10.1016/j.yexmp.2017.06.010. Epub 2017 Jul 3.
352 Abnormalities in mucin gene expression in Crohn's disease.Inflamm Bowel Dis. 1999 Feb;5(1):24-32. doi: 10.1097/00054725-199902000-00004.
353 Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus--a GISC study.Eur J Hum Genet. 1999 Jul;7(5):567-73. doi: 10.1038/sj.ejhg.5200328.
354 The Selective Autophagy Receptor Optineurin in Crohn's Disease.Front Immunol. 2018 Apr 10;9:766. doi: 10.3389/fimmu.2018.00766. eCollection 2018.
355 Expression and Clinical Significance of Elafin in Inflammatory Bowel Disease.Inflamm Bowel Dis. 2017 Dec;23(12):2134-2141. doi: 10.1097/MIB.0000000000001252.
356 Association of SEEK1 polymorphisms in Crohn's disease.Hum Immunol. 2004 Jul;65(7):706-9. doi: 10.1016/j.humimm.2004.04.002.
357 IL18 polymorphism is associated with an increased risk of Crohn's disease.J Gastroenterol. 2002 Nov;37 Suppl 14:111-6. doi: 10.1007/BF03326428.
358 Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease.Am J Gastroenterol. 2010 Feb;105(2):452-9. doi: 10.1038/ajg.2009.643. Epub 2009 Nov 10.
359 Serum trefoil factor 3 predicts disease activity in patients with ulcerative colitis.Eur Rev Med Pharmacol Sci. 2019 Jan;23(2):788-794. doi: 10.26355/eurrev_201901_16893.
360 Low 6-thioguanine nucleotide level: Effective in maintaining remission in Chinese patients with Crohn's disease.J Gastroenterol Hepatol. 2019 Apr;34(4):679-685. doi: 10.1111/jgh.14465. Epub 2018 Sep 27.
361 Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease.Clin Immunol. 2004 Sep;112(3):239-46. doi: 10.1016/j.clim.2004.04.009.
362 Gender Differences and Other Factors Associated with Weight Gain Following Initiation of Infliximab: A Post Hoc Analysis of Clinical Trials.Inflamm Bowel Dis. 2020 Jan 1;26(1):125-131. doi: 10.1093/ibd/izz133.
363 The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4.J Immunol. 2007 Sep 1;179(5):3109-18. doi: 10.4049/jimmunol.179.5.3109.
364 Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease.J Proteome Res. 2007 Mar;6(3):1114-25. doi: 10.1021/pr060433m.
365 Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.Gut. 2006 Aug;55(8):1114-23. doi: 10.1136/gut.2005.082107. Epub 2006 Feb 9.
366 Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease.J Mol Med (Berl). 2006 Dec;84(12):1055-66. doi: 10.1007/s00109-006-0100-2. Epub 2006 Oct 21.
367 Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes.Inflamm Bowel Dis. 2006 Jul;12(7):606-11. doi: 10.1097/01.ibd.0000225346.23765.6b.
368 A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.Nat Immunol. 2007 May;8(5):497-503. doi: 10.1038/ni1459. Epub 2007 Apr 15.
369 Signature biomarkers in Crohn's disease: toward a molecular classification.Mucosal Immunol. 2008 Sep;1(5):399-411. doi: 10.1038/mi.2008.32. Epub 2008 Jul 2.
370 Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.FEBS Lett. 2006 Oct 2;580(22):5344-50. doi: 10.1016/j.febslet.2006.08.083. Epub 2006 Sep 12.
371 An SNP linkage scan identifies significant Crohn's disease loci on chromosomes 13q13.3 and, in Jewish families, on 1p35.2 and 3q29.Genes Immun. 2008 Mar;9(2):161-7. doi: 10.1038/sj.gene.6364460. Epub 2008 Jan 31.
372 Sequence variation, linkage disequilibrium and association with Crohn's disease on chromosome 5q31.Genes Immun. 2006 Jul;7(5):359-65. doi: 10.1038/sj.gene.6364307. Epub 2006 May 18.
373 Sensitivity of intestinal fibroblasts to TNF-related apoptosis-inducing ligand-mediated apoptosis in Crohn's disease.Scand J Gastroenterol. 2008;43(11):1334-45. doi: 10.1080/00365520802200010.
374 Identification of Chitinase-3-Like Protein 1 as a Novel Neutrophil Antigenic Target in Crohn's Disease.J Crohns Colitis. 2019 Jul 25;13(7):894-904. doi: 10.1093/ecco-jcc/jjz012.
375 Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.Gastroenterology. 2015 Apr;148(4):794-805. doi: 10.1053/j.gastro.2014.12.030. Epub 2014 Dec 31.
376 Reduced Human -defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.Inflamm Bowel Dis. 2016 May;22(5):1119-28. doi: 10.1097/MIB.0000000000000707.
377 Genetic Complexity of Crohn's Disease in Two Large Ashkenazi Jewish Families.Gastroenterology. 2016 Oct;151(4):698-709. doi: 10.1053/j.gastro.2016.06.040. Epub 2016 Jul 1.
378 Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease.Am J Gastroenterol. 2019 May;114(5):777-785. doi: 10.14309/ajg.0000000000000237.
379 Variable outcome in infantile-onset inflammatory bowel disease in an Asian cohort.World J Gastroenterol. 2016 Dec 28;22(48):10653-10662. doi: 10.3748/wjg.v22.i48.10653.
380 Association between genetic polymorphisms in interferon regulatory factor 5 (IRF5) gene and Malaysian patients with Crohn's disease.J Dig Dis. 2015 Apr;16(4):205-16. doi: 10.1111/1751-2980.12229.
381 Risk predisposition for Crohn disease: a "mnage trois" combining IRGM allele, miRNA and xenophagy.Autophagy. 2011 Jul;7(7):786-7. doi: 10.4161/auto.7.7.15595. Epub 2011 Jul 1.
382 Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome.PLoS One. 2019 Feb 28;14(2):e0213108. doi: 10.1371/journal.pone.0213108. eCollection 2019.
383 A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.PLoS Genet. 2012;8(3):e1002559. doi: 10.1371/journal.pgen.1002559. Epub 2012 Mar 8.
384 Prevalence of Mycobacterium avium subspecies paratuberculosis IS 900 DNA in biopsy tissues from patients with Crohn's disease: histopathological and molecular comparison with Johne's disease in Fars province of Iran.BMC Infect Dis. 2019 Jan 7;19(1):23. doi: 10.1186/s12879-018-3619-2.
385 Pharmacology, efficacy and safety of JAK inhibitors in Crohn's disease.Best Pract Res Clin Gastroenterol. 2019 Feb-Apr;38-39:101606. doi: 10.1016/j.bpg.2019.03.002. Epub 2019 Mar 6.
386 Human Gut Microbiome Transplantation in Ileitis Prone Mice: A Tool for the Functional Characterization of the Microbiota in Inflammatory Bowel Disease Patients.Inflamm Bowel Dis. 2020 Feb 11;26(3):347-359. doi: 10.1093/ibd/izz242.
387 Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's disease.PLoS One. 2017 Oct 13;12(10):e0185855. doi: 10.1371/journal.pone.0185855. eCollection 2017.
388 CARD4/NOD1 is not involved in inflammatory bowel disease.Gut. 2003 Jan;52(1):71-4. doi: 10.1136/gut.52.1.71.
389 Peptidoglycan Metabolite Photoaffinity Reporters Reveal Direct Binding to Intracellular Pattern Recognition Receptors and Arf GTPases.ACS Chem Biol. 2019 Mar 15;14(3):405-414. doi: 10.1021/acschembio.8b01038. Epub 2019 Feb 20.
390 Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.Inflamm Bowel Dis. 2012 Apr;18(4):603-12. doi: 10.1002/ibd.21851. Epub 2011 Sep 1.
391 Accounting for eXentricities: analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases.PLoS One. 2014 Dec 5;9(12):e113684. doi: 10.1371/journal.pone.0113684. eCollection 2014.
392 Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.PLoS One. 2013 Nov 5;8(11):e77773. doi: 10.1371/journal.pone.0077773. eCollection 2013.
393 Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1.J Immunol. 2019 Oct 1;203(7):1820-1829. doi: 10.4049/jimmunol.1800419. Epub 2019 Aug 26.
394 VAAST 2.0: improved variant classification and disease-gene identification using a conservation-controlled amino acid substitution matrix.Genet Epidemiol. 2013 Sep;37(6):622-34. doi: 10.1002/gepi.21743. Epub 2013 Jul 8.
395 Diffusion-weighted magnetic resonance enterography for prediction of response to tumor necrosis factor inhibitors in stricturing Crohn's disease.Abdom Radiol (NY). 2018 Dec;43(12):3207-3212. doi: 10.1007/s00261-018-1626-9.
396 Association of NOD2 and IL23R with inflammatory bowel disease in Puerto Rico.PLoS One. 2014 Sep 26;9(9):e108204. doi: 10.1371/journal.pone.0108204. eCollection 2014.
397 Activation of NLRP3 Inflammasome in Inflammatory Bowel Disease: Differences Between Crohn's Disease and Ulcerative Colitis.Dig Dis Sci. 2017 Sep;62(9):2348-2356. doi: 10.1007/s10620-017-4609-8. Epub 2017 May 18.
398 Effects of Recombinant Human Growth Hormone in Children with Crohn's Disease on the Muscle-Bone Unit: A Preliminary Study.Horm Res Paediatr. 2018;90(2):128-131. doi: 10.1159/000492398. Epub 2018 Aug 27.
399 Diversity of Gut Microbiota Affecting Serum Level of Undercarboxylated Osteocalcin in Patients with Crohn's Disease.Nutrients. 2019 Jul 8;11(7):1541. doi: 10.3390/nu11071541.
400 Novel Associations Between Major Histocompatibility Complex and Pediatric-onset Inflammatory Bowel Disease.J Pediatr Gastroenterol Nutr. 2016 Apr;62(4):567-72. doi: 10.1097/MPG.0000000000000984.
401 Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease.Clin Gastroenterol Hepatol. 2019 Feb;17(3):486-493. doi: 10.1016/j.cgh.2018.04.060. Epub 2018 May 8.
402 Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.Gastroenterology. 2013 Aug;145(2):339-47. doi: 10.1053/j.gastro.2013.04.040. Epub 2013 Apr 25.
403 Caspase recruitment domain (CARD) family (CARD9, CARD10, CARD11, CARD14 and CARD15) are increased during active inflammation in patients with inflammatory bowel disease.J Inflamm (Lond). 2018 Jul 11;15:13. doi: 10.1186/s12950-018-0189-4. eCollection 2018.
404 Anti-TNF Re-induction Is as Effective, Simpler, and Cheaper Compared With Dose Interval Shortening for Secondary Loss of Response in Crohn's Disease.J Crohns Colitis. 2018 Feb 28;12(3):280-288. doi: 10.1093/ecco-jcc/jjx144.
405 CCDC88B is required for pathogenesis of inflammatory bowel disease.Nat Commun. 2017 Oct 13;8(1):932. doi: 10.1038/s41467-017-01381-y.
406 Inflammatory gene expression profiles in Crohn's disease and ulcerative colitis: a comparative analysis using a reverse transcriptase multiplex ligation-dependent probe amplification protocol.J Crohns Colitis. 2013 Sep;7(8):622-30. doi: 10.1016/j.crohns.2012.08.015. Epub 2012 Sep 24.
407 Dendritic cells from Crohn's disease patients show aberrant STAT1 and STAT3 signaling.PLoS One. 2013 Aug 7;8(8):e70738. doi: 10.1371/journal.pone.0070738. eCollection 2013.
408 Recruitment of activated neutrophils correlates with disease severity in adult Crohn's disease.Clin Exp Immunol. 2019 Feb;195(2):251-264. doi: 10.1111/cei.13226. Epub 2018 Nov 28.
409 mTNF reverse signalling induced by TNF antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.Gut. 2013 Mar;62(3):376-86. doi: 10.1136/gutjnl-2011-300384. Epub 2012 Apr 25.
410 Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease.World J Gastroenterol. 2013 Aug 14;19(30):4935-43. doi: 10.3748/wjg.v19.i30.4935.
411 Gut Barrier Dysfunction-A Primary Defect in Twins with Crohn's Disease Predominantly Caused by Genetic Predisposition.J Crohns Colitis. 2018 Nov 9;12(10):1200-1209. doi: 10.1093/ecco-jcc/jjy045.
412 Cytokine IL9 Triggers the Pathogenesis of Inflammatory Bowel Disease Through the miR21-CLDN8 Pathway.Inflamm Bowel Dis. 2018 Sep 15;24(10):2211-2223. doi: 10.1093/ibd/izy187.
413 MCL-1 is modulated in Crohn's disease fibrosis by miR-29b via IL-6 and IL-8.Cell Tissue Res. 2017 May;368(2):325-335. doi: 10.1007/s00441-017-2576-1. Epub 2017 Feb 11.
414 Association Between Plasma Level of Collagen Type III Alpha 1 Chain and Development of Strictures in Pediatric Patients With Crohn's Disease.Clin Gastroenterol Hepatol. 2019 Aug;17(9):1799-1806. doi: 10.1016/j.cgh.2018.09.008. Epub 2018 Sep 10.
415 Postoperative Interleukin-6 Predicts Intra-abdominal Septic Complications at an Early Stage After Elective Intestinal Operation for Crohn's Disease Patients.Inflamm Bowel Dis. 2018 Aug 16;24(9):1992-2000. doi: 10.1093/ibd/izy090.
416 Expression and gene polymorphisms of the chemokine CXCL5 in colorectal cancer patients.Int J Oncol. 2007 Jul;31(1):97-102.
417 Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.Gastroenterology. 2019 Feb;156(3):692-707.e7. doi: 10.1053/j.gastro.2018.10.023. Epub 2018 Oct 10.
418 Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?.PLoS One. 2013;8(2):e56989. doi: 10.1371/journal.pone.0056989. Epub 2013 Feb 21.
419 Association of higher DEFB4 genomic copy number with Crohn's disease.Am J Gastroenterol. 2010 Feb;105(2):354-9. doi: 10.1038/ajg.2009.582. Epub 2009 Oct 6.
420 Exome sequencing identifies DLG1 as a novel gene for potential susceptibility to Crohn's disease in a Chinese family study.PLoS One. 2014 Jun 17;9(6):e99807. doi: 10.1371/journal.pone.0099807. eCollection 2014.
421 SALSA-A dance on a slippery floor with changing partners.Mol Immunol. 2017 Sep;89:100-110. doi: 10.1016/j.molimm.2017.05.029. Epub 2017 Jun 28.
422 ACG Clinical Guideline: Management of Crohn's Disease in Adults.Am J Gastroenterol. 2018 Apr;113(4):481-517. doi: 10.1038/ajg.2018.27. Epub 2018 Mar 27.
423 Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.Mucosal Immunol. 2018 Nov;11(6):1630-1639. doi: 10.1038/s41385-018-0062-z. Epub 2018 Aug 16.
424 Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.Gastroenterology. 2018 Apr;154(5):1405-1420.e2. doi: 10.1053/j.gastro.2017.12.016. Epub 2017 Dec 21.
425 Usefulness of confocal laser endomicroscopy for predicting postoperative recurrence in patients with Crohn's disease: apilot study.Gastrointest Endosc. 2019 Jul;90(1):151-157. doi: 10.1016/j.gie.2019.02.030. Epub 2019 Mar 5.
426 The distinct features of microbial 'dysbiosis' of Crohn's disease do not occur to the same extent in their unaffected, genetically-linked kindred.PLoS One. 2017 Feb 21;12(2):e0172605. doi: 10.1371/journal.pone.0172605. eCollection 2017.
427 Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.Inflamm Bowel Dis. 2013 Jul;19(8):1662-70. doi: 10.1097/MIB.0b013e318281f275.
428 Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.Gut. 2014 Jan;63(1):80-7. doi: 10.1136/gutjnl-2013-305193. Epub 2013 Jul 14.
429 FcRL3 gene promoter variant is associated with peripheral arthritis in Crohn's disease.Inflamm Bowel Dis. 2009 Sep;15(9):1351-7. doi: 10.1002/ibd.20895.
430 FKBP11 protects intestinal epithelial cells against inflammationinduced apoptosis via the JNKcaspase pathway in Crohn's disease.Mol Med Rep. 2018 Nov;18(5):4428-4438. doi: 10.3892/mmr.2018.9485. Epub 2018 Sep 14.
431 TAP gene transporter polymorphism in inflammatory bowel diseases.Scand J Gastroenterol. 1997 Oct;32(10):1022-7. doi: 10.3109/00365529709011219.
432 A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.Gut. 2013 Oct;62(10):1440-5. doi: 10.1136/gutjnl-2012-302865. Epub 2012 Aug 30.
433 Cryptic 13q34 and 4q35.2 Deletions in an Italian Family.Cytogenet Genome Res. 2015;147(1):24-30. doi: 10.1159/000442068. Epub 2015 Dec 9.
434 Association of FUT2 and ABO with Crohn's disease in Koreans.J Gastroenterol Hepatol. 2020 Jan;35(1):104-109. doi: 10.1111/jgh.14766. Epub 2019 Aug 7.
435 Identification of differentially expressed genes, associated functional terms pathways, and candidate diagnostic biomarkers in inflammatory bowel diseases by bioinformatics analysis.Exp Ther Med. 2019 Jul;18(1):278-288. doi: 10.3892/etm.2019.7541. Epub 2019 May 3.
436 Parallel Changes in Harvey-Bradshaw Index, TNF, and Intestinal Fatty Acid Binding Protein in Response to Infliximab in Crohn's Disease.Gastroenterol Res Pract. 2017;2017:1745918. doi: 10.1155/2017/1745918. Epub 2017 Oct 23.
437 Differential diagnosis of Crohn's disease using antibodies to glycoprotein 2 and Saccharomyces cerevisiae.Turk J Gastroenterol. 2019 Jan;30(1):21-27. doi: 10.5152/tjg.2018.18135.
438 Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis.J Crohns Colitis. 2018 Nov 15;12(11):1348-1358. doi: 10.1093/ecco-jcc/jjy118.
439 Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.Biomed Res Int. 2015;2015:834805. doi: 10.1155/2015/834805. Epub 2015 Sep 21.
440 Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1128-E1137. doi: 10.1073/pnas.1616783114. Epub 2017 Feb 1.
441 Extended haplotype association study in Crohn's disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-B pathway gene, HEATR3.Genes Immun. 2013 Jul-Aug;14(5):310-6. doi: 10.1038/gene.2013.19. Epub 2013 Apr 25.
442 Identifying candidate genes for discrimination of ulcerative colitis and Crohn's disease.Mol Biol Rep. 2014 Oct;41(10):6349-55. doi: 10.1007/s11033-014-3469-y. Epub 2014 Sep 3.
443 Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.Hum Mol Genet. 2010 May 15;19(10):2059-67. doi: 10.1093/hmg/ddq078. Epub 2010 Feb 22.
444 Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease.Gut. 1998 Aug;43(2):210-5. doi: 10.1136/gut.43.2.210.
445 Haplotype synthesis analysis reveals functional variants underlying known genome-wide associated susceptibility loci.Bioinformatics. 2016 Jul 15;32(14):2136-42. doi: 10.1093/bioinformatics/btw125. Epub 2016 Mar 21.
446 Complex interaction between HNRNPD mutations and risk polymorphisms is associated with discordant Crohn's disease in monozygotic twins.Autoimmunity. 2017 Aug;50(5):275-276. doi: 10.1080/08916934.2017.1300883. Epub 2017 Mar 16.
447 Heat shock factor 2 levels are associated with the severity of ulcerative colitis.PLoS One. 2014 Feb 12;9(2):e88822. doi: 10.1371/journal.pone.0088822. eCollection 2014.
448 Heat shock protein family A member 6 combined with clinical characteristics for the differential diagnosis of intestinal Behet's disease.J Dig Dis. 2018 Jun;19(6):350-358. doi: 10.1111/1751-2980.12613.
449 Exome sequencing identifies novel compound heterozygous IFNA4 and IFNA10 mutations as a cause of impaired function in Crohn's disease patients.Sci Rep. 2015 May 22;5:10514. doi: 10.1038/srep10514.
450 IL-36 sustains a proinflammatory self-amplifying loop with IL-17C in anti-TNF-induced psoriasiform skin lesions of patients with Crohn's disease.Inflamm Bowel Dis. 2014 Nov;20(11):1891-901. doi: 10.1097/MIB.0000000000000198.
451 Interleukin-18 is increased only in a minority of patients with active Crohn's disease.Int J Colorectal Dis. 2007 Sep;22(9):1013-20. doi: 10.1007/s00384-007-0282-2. Epub 2007 Feb 21.
452 The novel interleukin-1 cytokine family members in inflammatory diseases.Curr Opin Rheumatol. 2017 Mar;29(2):208-213. doi: 10.1097/BOR.0000000000000361.
453 mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease.Cells. 2019 Aug 18;8(8):924. doi: 10.3390/cells8080924.
454 Interleukin-34 sustains inflammatory pathways in the gut.Clin Sci (Lond). 2015 Aug;129(3):271-80. doi: 10.1042/CS20150132.
455 Variation in Interleukin 6 Receptor Gene Associates With Risk of Crohn's Disease and Ulcerative Colitis.Gastroenterology. 2018 Aug;155(2):303-306.e2. doi: 10.1053/j.gastro.2018.05.022. Epub 2018 Jul 5.
456 F-calprotectin and Blood Markers Correlate to Quality of Life in Pediatric Inflammatory Bowel Disease.J Pediatr Gastroenterol Nutr. 2017 Nov;65(5):539-545. doi: 10.1097/MPG.0000000000001540.
457 Population Density and Risk of Inflammatory Bowel Disease: A Prospective Population-Based Study in 13 Countries or Regions in Asia-Pacific.Am J Gastroenterol. 2019 Jan;114(1):107-115. doi: 10.1038/s41395-018-0233-2.
458 Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).Inflamm Bowel Dis. 2013 Feb;19(2):230-9. doi: 10.1002/ibd.23007.
459 Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province.Clin Rheumatol. 2015 Oct;34(10):1729-36. doi: 10.1007/s10067-014-2761-5. Epub 2014 Aug 23.
460 An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway.Cell Cycle. 2008 Aug 15;7(16):2570-83. doi: 10.4161/cc.7.16.6524. Epub 2008 Aug 30.
461 Critical role of Keratin 1 in maintaining epithelial barrier and correlation of its down-regulation with the progression of inflammatory bowel disease.Gene. 2017 Apr 15;608:13-19. doi: 10.1016/j.gene.2017.01.015. Epub 2017 Jan 20.
462 Genetic determinants associated with early age of diagnosis of IBD.Dis Colon Rectum. 2015 Mar;58(3):321-7. doi: 10.1097/DCR.0000000000000274.
463 Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis.Inflamm Bowel Dis. 2012 Nov;18(11):2169-79. doi: 10.1002/ibd.22936. Epub 2012 Feb 28.
464 Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.World J Gastroenterol. 2019 Apr 14;25(14):1753-1763. doi: 10.3748/wjg.v25.i14.1753.
465 Replication of genetic variation in the MYO9B gene in Crohn's disease.Hum Immunol. 2011 Jul;72(7):592-7. doi: 10.1016/j.humimm.2011.03.025. Epub 2011 Apr 12.
466 Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/-catenin signaling in Crohn's disease.Biochem Biophys Res Commun. 2017 Apr 8;485(3):635-642. doi: 10.1016/j.bbrc.2017.02.034. Epub 2017 Feb 7.
467 The Incidence and Definition of Crohn's Disease of the Pouch: A Systematic Review and Meta-analysis.Inflamm Bowel Dis. 2019 Aug 20;25(9):1474-1480. doi: 10.1093/ibd/izz005.
468 Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study.Lancet Gastroenterol Hepatol. 2019 May;4(5):341-353. doi: 10.1016/S2468-1253(19)30012-3. Epub 2019 Feb 27.
469 Transcriptomic Analysis and High-dimensional Phenotypic Mapping of Mononuclear Phagocytes in Mesenteric Lymph Nodes Reveal Differences Between Ulcerative Colitis and Crohn's Disease.J Crohns Colitis. 2020 Mar 13;14(3):393-405. doi: 10.1093/ecco-jcc/jjz156.
470 Paediatric inflammatory bowel disease: review with a focus on practice in low- to middle-income countries.Paediatr Int Child Health. 2019 Feb;39(1):48-58. doi: 10.1080/20469047.2019.1575056.
471 Mucosal genome-wide methylation changes in inflammatory bowel disease.Inflamm Bowel Dis. 2012 Nov;18(11):2128-37. doi: 10.1002/ibd.22942. Epub 2012 Mar 14.
472 Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine.Autoimmunity. 2019 Mar;52(2):48-56. doi: 10.1080/08916934.2019.1613382. Epub 2019 May 13.
473 DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-B Signaling.Oxid Med Cell Longev. 2019 Mar 24;2019:5294105. doi: 10.1155/2019/5294105. eCollection 2019.
474 Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.World J Gastroenterol. 2012 Nov 28;18(44):6409-19; discussion p. 6417-8. doi: 10.3748/wjg.v18.i44.6409.
475 Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.Cell Death Dis. 2018 Jun 7;9(6):691. doi: 10.1038/s41419-018-0734-3.
476 MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu.Front Immunol. 2018 May 28;9:1078. doi: 10.3389/fimmu.2018.01078. eCollection 2018.
477 Genetic association and functional role of Crohn disease risk alleles involved in microbial sensing, autophagy, and endoplasmic reticulum (ER) stress.Autophagy. 2013 Dec;9(12):2046-55. doi: 10.4161/auto.26337. Epub 2013 Nov 14.
478 The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis.Mucosal Immunol. 2017 Jul;10(4):983-995. doi: 10.1038/mi.2016.102. Epub 2016 Nov 30.
479 A meta-analysis of the relationship between MYO9B gene polymorphisms and susceptibility to Crohn's disease and ulcerative colitis.Hum Immunol. 2016 Oct;77(10):990-996. doi: 10.1016/j.humimm.2016.07.008. Epub 2016 Jul 18.
480 CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors.J Immunol. 2019 Jan 1;202(1):171-182. doi: 10.4049/jimmunol.1701153. Epub 2018 Nov 30.
481 The use of selected neutrophil protein plasma concentrations in the diagnosis of Crohn's disease and ulcerative colitis - a preliminary report.Postepy Hig Med Dosw (Online). 2017 Apr 6;71(0):243-253. doi: 10.5604/01.3001.0010.3810.
482 Effect of interleukin-17 on gene expression profile of fibroblasts from Crohn's disease patients.J Crohns Colitis. 2014 Oct;8(10):1208-16. doi: 10.1016/j.crohns.2014.02.009. Epub 2014 Mar 15.
483 Gastrointestinal Tract Pathology in a BALB/c Niemann-Pick Disease Type C1 Null Mouse Model.Dig Dis Sci. 2018 Apr;63(4):870-880. doi: 10.1007/s10620-018-4914-x. Epub 2018 Jan 22.
484 Crohn's disease loci are common targets of protozoa-driven selection.Mol Biol Evol. 2013 May;30(5):1077-87. doi: 10.1093/molbev/mst020. Epub 2013 Feb 6.
485 Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.J Gastroenterol. 2018 Feb;53(2):172-180. doi: 10.1007/s00535-017-1416-0. Epub 2017 Nov 30.
486 Effects of haptoglobin polymorphisms and deficiency on susceptibility to inflammatory bowel disease and on severity of murine colitis.Gut. 2012 Apr;61(4):528-34. doi: 10.1136/gut.2011.240978. Epub 2011 Jun 27.
487 Antibodies against glycoprotein 2 display diagnostic advantages over ASCA in distinguishing CD from intestinal tuberculosis and intestinal Behet's disease.Clin Transl Gastroenterol. 2018 Feb 15;9(2):e133. doi: 10.1038/ctg.2018.1.
488 Gastrointestinal Behcet's-like disease with myelodysplastic neoplasms with trisomy 8: a French case series and literature review.Leuk Lymphoma. 2019 Jul;60(7):1782-1788. doi: 10.1080/10428194.2018.1542152. Epub 2018 Nov 20.
489 Expression and localization of pannexin-1 hemichannels in human colon in health and disease.Neurogastroenterol Motil. 2013 Jun;25(6):e395-405. doi: 10.1111/nmo.12130. Epub 2013 Apr 17.
490 Pannexin-2 is expressed in the human colon with extensive localization in the enteric nervous system.Neurogastroenterol Motil. 2015 May;27(5):672-83. doi: 10.1111/nmo.12541. Epub 2015 Mar 14.
491 Genetic susceptibility to inflammation and colonic transit in lower functional gastrointestinal disorders: preliminary analysis.Neurogastroenterol Motil. 2011 Oct;23(10):935-e398. doi: 10.1111/j.1365-2982.2011.01749.x. Epub 2011 Jul 14.
492 Genetic Association of Peptidoglycan Recognition Protein Variants with Inflammatory Bowel Disease.PLoS One. 2013 Jun 19;8(6):e67393. doi: 10.1371/journal.pone.0067393. Print 2013.
493 IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes.Int J Mol Med. 2011 Mar;27(3):469-77. doi: 10.3892/ijmm.2010.591. Epub 2010 Dec 27.
494 A phase 1 open-label trial shows that smad7 antisense oligonucleotide (GED0301) does not increase the risk of small bowel strictures in Crohn's disease. Aliment Pharmacol Ther. 2012 Nov;36(9):850-7.
495 PRDM5 promotes the apoptosis of epithelial cells induced by IFN- during Crohn's disease.Pathol Res Pract. 2017 Jun;213(6):666-673. doi: 10.1016/j.prp.2016.12.004. Epub 2016 Dec 5.
496 Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.J Gastroenterol Hepatol. 2012 Aug;27(8):1388-94. doi: 10.1111/j.1440-1746.2012.07147.x.
497 Decreased Expression of Prox1 Is Associated With Postoperative Recurrence in Crohn's Disease.J Crohns Colitis. 2018 Nov 9;12(10):1210-1218. doi: 10.1093/ecco-jcc/jjy091.
498 Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease.Protein Cell. 2017 Sep;8(9):686-695. doi: 10.1007/s13238-017-0413-7. Epub 2017 May 18.
499 Longest form of CCTG microsatellite repeat in the promoter of the CD2BP1/PSTPIP1 gene is associated with aseptic abscesses and with Crohn disease in French patients.Dig Dis Sci. 2010 Jun;55(6):1681-8. doi: 10.1007/s10620-009-0929-7.
500 Evaluation of the efficacy of octreotide LAR in the treatment of Crohn's disease associated refractory diarrhea.Scand J Gastroenterol. 2017 May;52(5):564-569. doi: 10.1080/00365521.2017.1284893. Epub 2017 Feb 13.
501 NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2.Gut. 2012 Jul;61(7):1028-35. doi: 10.1136/gutjnl-2011-300078. Epub 2011 Sep 7.
502 Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants.Sci Rep. 2019 Jun 24;9(1):9168. doi: 10.1038/s41598-019-45701-2.
503 Prognostic significance of faecal eosinophil granule proteins in inflammatory bowel disease.Scand J Gastroenterol. 2019 Oct;54(10):1237-1244. doi: 10.1080/00365521.2019.1670251. Epub 2019 Oct 2.
504 Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity inCrohn's Disease.Gastroenterology. 2017 Jul;153(1):219-232. doi: 10.1053/j.gastro.2017.04.002. Epub 2017 Apr 9.
505 R-Spondins Are Expressed by the Intestinal Stroma and are Differentially Regulated during Citrobacter rodentium- and DSS-Induced Colitis in Mice.PLoS One. 2016 Apr 5;11(4):e0152859. doi: 10.1371/journal.pone.0152859. eCollection 2016.
506 Preliminary exploration of the potential of spliceosome-associated protein 130 for predicting disease severity in Crohn's disease.Ann N Y Acad Sci. 2020 Feb;1462(1):128-138. doi: 10.1111/nyas.14240. Epub 2019 Oct 3.
507 Selenium, selenoprotein genes and Crohn's disease in a case-control population from Auckland, New Zealand.Nutrients. 2012 Sep;4(9):1247-59. doi: 10.3390/nu4091247. Epub 2012 Sep 7.
508 Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.Scand J Gastroenterol. 2016;51(6):684-91. doi: 10.3109/00365521.2015.1133698. Epub 2016 Jan 14.
509 T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.J Surg Res. 2014 Aug;190(2):457-64. doi: 10.1016/j.jss.2014.01.019. Epub 2014 Jan 17.
510 TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease.Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G487-98. doi: 10.1152/ajpgi.00347.2013. Epub 2014 Jul 3.
511 An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B12 in Chinese Patients with Crohn's Disease.Dig Dis. 2017;35(5):463-471. doi: 10.1159/000471848. Epub 2017 May 5.
512 Utility of in vitro interferon- release assay in differential diagnosis between intestinal tuberculosis and Crohn's disease.J Dig Dis. 2013 Feb;14(2):68-75. doi: 10.1111/1751-2980.12017.
513 Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population.Hum Immunol. 2012 Apr;73(4):416-20. doi: 10.1016/j.humimm.2012.01.015. Epub 2012 Feb 2.
514 TNFAIP6 is a potential biomarker of disease activity in inflammatory bowel disease.Biomark Med. 2016 May;10(5):473-83. doi: 10.2217/bmm.16.9. Epub 2016 Apr 18.
515 Up-regulation and pre-activation of TRAF3 and TRAF5 in inflammatory bowel disease.Int J Med Sci. 2013;10(2):156-63. doi: 10.7150/ijms.5457. Epub 2013 Jan 3.
516 IB kinase phosphorylation of TRAF4 downregulates innate immune signaling.Mol Cell Biol. 2012 Jul;32(13):2479-89. doi: 10.1128/MCB.00106-12. Epub 2012 Apr 30.
517 Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease.J Gastroenterol Hepatol. 2019 Dec;34(12):2118-2125. doi: 10.1111/jgh.14696. Epub 2019 Jun 18.
518 Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease.Gastroenterology. 2016 May;150(5):1196-1207. doi: 10.1053/j.gastro.2016.01.031. Epub 2016 Feb 4.
519 Gut Microbial Signatures Underline Complicated Crohn's Disease but Vary Between Cohorts; An In Silico Approach.Inflamm Bowel Dis. 2019 Jan 10;25(2):217-225. doi: 10.1093/ibd/izy328.
520 Granulomas in Crohn's disease: are newly discovered genetic variants involved?.J Crohns Colitis. 2010 Oct;4(4):438-43. doi: 10.1016/j.crohns.2010.02.006. Epub 2010 Apr 22.
521 Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.Hum Mol Genet. 2010 Sep 1;19(17):3468-76. doi: 10.1093/hmg/ddq248. Epub 2010 Jun 22.
522 A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.Nat Genet. 2010 Jun;42(6):515-9. doi: 10.1038/ng.583. Epub 2010 May 9.
523 Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.Circ Cardiovasc Genet. 2009 Apr;2(2):134-41. doi: 10.1161/CIRCGENETICS.108.825273. Epub 2009 Feb 12.
524 NOD2 status and human ileal gene expression.Inflamm Bowel Dis. 2010 Oct;16(10):1649-57. doi: 10.1002/ibd.21208.
525 Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.Ann Hum Genet. 2010 Nov;74(6):489-97. doi: 10.1111/j.1469-1809.2010.00606.x. Epub 2010 Sep 15.
526 Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients.Genes Immun. 2012 Sep;13(6):474-80. doi: 10.1038/gene.2012.21. Epub 2012 May 17.
527 Enterovirulent E. coli in inflammatory and noninflammatory bowel diseases.Folia Microbiol (Praha). 2009;54(1):81-6. doi: 10.1007/s12223-009-0012-y. Epub 2009 Mar 29.
528 TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.Gastroenterology. 2011 Sep;141(3):972-981.e1-2. doi: 10.1053/j.gastro.2011.05.043. Epub 2011 May 27.
529 Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.J Immunol. 2011 Apr 1;186(7):4027-38. doi: 10.4049/jimmunol.1000085. Epub 2011 Feb 18.
530 Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.Inflamm Bowel Dis. 2009 Jun;15(6):883-9. doi: 10.1002/ibd.20855.
531 Phenotypic associations of Crohn's disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss Cohort.Inflamm Bowel Dis. 2009 Sep;15(9):1358-67. doi: 10.1002/ibd.20892.
532 Genetic susceptibility factors in a cohort of 38 patients with SAPHO syndrome: a study of PSTPIP2, NOD2, and LPIN2 genes.J Rheumatol. 2010 Feb;37(2):401-9. doi: 10.3899/jrheum.090456. Epub 2009 Dec 23.
533 Caspase-8 regulates TNF--induced epithelial necroptosis and terminal ileitis.Nature. 2011 Sep 14;477(7364):335-9. doi: 10.1038/nature10400.
534 NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity.J Immunol. 2011 Apr 15;186(8):4649-55. doi: 10.4049/jimmunol.1003888. Epub 2011 Mar 7.
535 The genetics of NOD-like receptors in Crohn's disease.Tissue Antigens. 2010 Jul;76(1):48-56. doi: 10.1111/j.1399-0039.2010.01470.x. Epub 2010 Apr 6.
536 Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease.Dig Liver Dis. 2010 Aug;42(8):544-8. doi: 10.1016/j.dld.2009.12.005. Epub 2010 Jan 12.
537 Association of the RAVER2 gene with increased susceptibility for ulcerative colitis.Hum Immunol. 2012 Jul;73(7):732-5. doi: 10.1016/j.humimm.2012.04.018. Epub 2012 May 2.
538 Polymorphisms of the apoptosis-associated gene DP1L1 (deleted in polyposis 1-like 1) in colon cancer and inflammatory bowel disease.J Cancer Res Clin Oncol. 2010 Jun;136(6):795-802. doi: 10.1007/s00432-009-0719-9. Epub 2009 Nov 19.
539 Influence of smoking on colonic gene expression profile in Crohn's disease.PLoS One. 2009 Jul 15;4(7):e6210. doi: 10.1371/journal.pone.0006210.
540 Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis.Am J Physiol Gastrointest Liver Physiol. 2011 Apr;300(4):G586-97. doi: 10.1152/ajpgi.00041.2010. Epub 2011 Jan 6.
541 Distinct differences in tachykinin gene expression in ulcerative colitis, Crohn's disease and diverticular disease: a role for hemokinin-1?.Neurogastroenterol Motil. 2011 May;23(5):475-83, e179-80. doi: 10.1111/j.1365-2982.2011.01685.x. Epub 2011 Feb 22.
542 Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease.Inflamm Bowel Dis. 2008 Apr;14(4):500-7. doi: 10.1002/ibd.20365.