Details of the Drug

General Information of Drug (ID: DM6AXV9)

Drug Name

TOL-101

Synonyms

MAb (transplant rejection), Tolera Therapeutics; Monoclonal antibody (transplant rejection), Tolera Therapeutics; Anti-TCR alpha/beta antibody (transplant rejection/type 1 diabetes/multiple sclerosis), Tolera

Indication

Disease Entry	ICD 11	Status	REF
Multiple sclerosis	8A40	Phase 1/2	[1]
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Drug Type

Antibody

Cross-matching ID

TTD ID: D07AKD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
T-cell receptor (TCR)	TT7AKW1	NOUNIPROTAC	Not Available	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT01154387) Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection. U.S. National Institutes of Health.
2	First-in-Human Study of the Safety and Efficacy of TOL101 Induction to Prevent Kidney Transplant Rejection. Am J Transplant. 2014 June; 14(6): 1346-1355.