General Information of Disease (ID: DISB2WZI)

Disease Name Multiple sclerosis
Synonyms insular sclerosis; generalised multiple sclerosis; generalized multiple sclerosis
Disease Class 8A40: Multiple sclerosis
Definition A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Disease Hierarchy
DIS3XM4N: Autoimmune disorder of central nervous system
DIS9H7BS: Demyelinating disease of central nervous system
DIS1SAB7: CNS demyelinating autoimmune disease
DIS6ZC3X: Brain disease
DISB2WZI: Multiple sclerosis
ICD Code
ICD-11
ICD-11: 8A40
Disease Identifiers
MONDO ID
MONDO_0005301
MESH ID
D009103
UMLS CUI
C0026769
MedGen ID
10123
Orphanet ID
802
SNOMED CT ID
24700007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 43 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Abatacept DMSA8RU Approved NA [1]
Alemtuzumab DMZL3IV Approved Antibody [2]
Alfuzosin DMZVMKF Approved Small molecular drug [3]
Antegren DMNC64R Approved Antibody [4]
ATryn antithrombin DM79Y2T Approved NA [5]
Baclofen DM0QV1J Approved Small molecular drug [6]
Betamethasone DMAHJEF Approved Small molecular drug [7]
Cladribine DM3JDRP Approved Small molecular drug [8]
Cortisone Acetate DMG8K57 Approved Small molecular drug [9]
Cyclophosphamide DM4O2Z7 Approved Small molecular drug [10]
Daclizumab DM6OZQV Approved Monoclonal antibody [11]
Dalfampridine DMM0PDO Approved Small molecular drug [12]
Dexamethasone DMMWZET Approved Small molecular drug [13]
Estriol DMOEM2I Approved Small molecular drug [14]
Everolimus DM8X2EH Approved Small molecular drug [15]
Fingolimod DM5JVAN Approved Small molecular drug [16]
Fludarabine DMVRLT7 Approved Small molecular drug [17]
Glatiramer Acetate DMAPV1B Approved Small molecular drug [18]
Hydrocortisone DMGEMB7 Approved Small molecular drug [19]
Ibudilast DM4LSPN Approved Small molecular drug [20]
Interferon beta-1a DM1A6RV Approved Protein/peptide drug [21]
Interferon beta-1b DMCN61Z Approved NA [22]
Leflunomide DMR8ONJ Approved Small molecular drug [23]
Methylprednisolone DM4BDON Approved Small molecular drug [24]
Methyltestosterone DMWLFGO Approved Small molecular drug [25]
Natalizumab DMAK85L Approved Monoclonal antibody [26]
Ocrelizumab DMEZ2KH Approved Antibody [27]
Ozanimod DMT6AM2 Approved NA [28]
PLEGRIDY DMAKXW9 Approved NA [29]
Ponesimod DMEAOYJ Approved Small molecular drug [30]
Prednisolone DMQ8FR2 Approved Small molecular drug [31]
Prednisone DM2HG4X Approved Small molecular drug [32]
Secukinumab DMYXT2U Approved Monoclonal antibody [33]
Siponimod DM2R86O Approved Small molecular drug [34]
Sirolimus DMGW1ID Approved Small molecular drug [35]
Sodium phosphate dibasic/sodium phosphate monobasic DMKY27B Approved NA [16]
TECFIDERA DM2OVDT Approved Small molecular drug [36]
Teriflunomide DMQ2FKJ Approved Small molecular drug [37]
Testosterone DM7HUNW Approved Small molecular drug [38]
Triamcinolone DM98IXF Approved Small molecular drug [39]
Ublituximab DMHTY9W Approved Antibody [40]
Vamorolone DM047HI Approved NA [20]
Zoledronate DMIXC7G Approved Small molecular drug [41]
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⏷ Show the Full List of 43 Drug(s)
This Disease is Treated as An Indication in 92 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ALKS 8700 DM4GH06 Phase 3 NA [20]
Atacicept DM8GFEV Phase 3 NA [42]
Biferonex DM57B9J Phase 3 NA [43]
BIIB-098 DMOOCCN Phase 3 NA [8]
Freeze-dried bee venom DMQPDMG Phase 3 NA [8]
Fumaric acid DMP83UZ Phase 3 Small molecular drug [44]
GDC-0853 DMBEL3Q Phase 3 NA [45]
Laquinamod DMMA0C7 Phase 3 Small molecular drug [46]
Laquinimod DM3IWS8 Phase 3 Small molecular drug [20]
LaViv DM6MEO5 Phase 3 NA [47]
Masitinib DMRSNEU Phase 3 Small molecular drug [20]
MD1003 DMVZ57G Phase 3 NA [8]
NB-001 DMOTHNK Phase 3 Small molecular drug [48]
NGF-hTNF DM50DW2 Phase 3 NA [49]
NU-100 DMA16IL Phase 3 NA [50]
Pixantrone DMQGR45 Phase 3 Small molecular drug [51]
Sivelestat DM6BZCV Phase 3 Small molecular drug [20]
Tolebrutinib DML19V6 Phase 3 Small molecule [52]
[3H](R)-(-)-baclofen DMLRHM5 Phase 3 Small molecular drug [53]
IR208 DM30Z38 Phase 2/3 NA [54]
Aimspro DMM4XUC Phase 2 NA [55]
Anti-LINGO DMZDDXN Phase 2 NA [56]
ATL1102 DM3POT6 Phase 2 NA [57]
ATX-MS-1467 DM8SA8B Phase 2 Vaccine [58]
AZ-01, PEGylated interferon-beta DMHFUJT Phase 2 NA [59]
AZD2624 DMZLGQV Phase 2 Small molecular drug [60]
BHT-3009 DM7ZM1H Phase 2 Vaccine [61]
BIIB 033 DM293JT Phase 2 Antibody [62]
CDP323 DMXYLTI Phase 2 Small molecular drug [63]
CHS-131 DMMRKPF Phase 2 NA [20]
Elezanumab DMCSXI4 Phase 2 Antibody [64]
ELIPRODIL DMIOGZM Phase 2 Small molecular drug [65]
Firategrast DMW2QYT Phase 2 Small molecular drug [66]
FLX-787 DMQX5UA Phase 2 NA [20]
FP-187 DMWZO21 Phase 2 NA [67]
Frexalimab DMMJTYP Phase 2 Antibody [68]
GEM-SP DMD5ZES Phase 2 NA [69]
GNbAC-1 DMQDIYW Phase 2 NA [70]
HP-184 DMNOMV2 Phase 2 Small molecular drug [71]
Imilecleucel-T DMT408C Phase 2 NA [72]
M2951 DMC5MQD Phase 2 NA [8]
MK-0812 DMRT8K4 Phase 2 Small molecular drug [73]
MLN1202 DM24SOL Phase 2 Small molecular drug [74]
MT-1303 DMSE9TH Phase 2 Small molecular drug [75]
NBI-5788 DMH9JFZ Phase 2 NA [76]
Opicinumab DMKVDGN Phase 2 NA [20]
PI-2301 DMIYIQC Phase 2 NA [77]
Plovamer acetate DM87FST Phase 2 NA [78]
RNS-60 DMDNRU1 Phase 2 NA [8]
RNS60 DMTHZ2V Phase 2 NA [79]
SBI-087 DMSUQFJ Phase 2 NA [80]
Tcelna DM9MKTJ Phase 2 NA [72]
Tovaxin DMN5YDE Phase 2 NA [81]
TV-1102 DM28M6I Phase 2 Antisense drug [82]
Valetizumab DMIKH67 Phase 2 Antibody [83]
Vatelizumab DM3V7QO Phase 2 Antibody [84]
VP-20621 DMVNES0 Phase 2 NA [85]
VX-15 DMLWM4G Phase 2 Antibody [86]
XP-23829 DMELUYN Phase 2 NA [87]
MOR-103 DMXVIQN Phase 1/2 Antibody [88]
TOL-101 DM6AXV9 Phase 1/2 Antibody [89]
ABT-555 DM5HZ0U Phase 1 NA [20]
ACT-101 DMQW7LR Phase 1 NA [8]
ARN-6039 DM4D85V Phase 1 NA [20]
ARX-424 DM4CZ2Y Phase 1 NA [90]
ASP-4058 DM1RD0T Phase 1 NA [91]
ATA188 DMUI3PC Phase 1 NA [8]
ATA190 DM2OZN4 Phase 1 NA [8]
AX-024 DMRQ32K Phase 1 NA [20]
BIIB061 DM9H6GO Phase 1 NA [92]
BIIB091 DMW49ZF Phase 1 Small molecule [93]
BIIB107 DMIA57S Phase 1 Monoclonal antibody [94]
CS-0777 DMG0SPO Phase 1 Small molecular drug [95]
GEH-120714 DMATPC1 Phase 1 NA [96]
GSK2618960 DMIVHDN Phase 1 NA [97]
GSK3888130? DMKD6IV Phase 1 Antibody [98]
GZ402668 DME6VX4 Phase 1 Antibody [99]
IC-84 DMEEIHL Phase 1 NA [100]
LAS-186323 DMV80DP Phase 1 NA [101]
MBP(75-95) DMAOYT8 Phase 1 NA [102]
MRF-008 DMU7BM0 Phase 1 NA [20]
Peginterferon beta DMQ4Z1P Phase 1 NA [103]
PF530 DMWSTV4 Phase 1 NA [20]
PRN2246 DMQNS51 Phase 1 NA [8]
RG6035 DMAO0NI Phase 1 Antibody [104]
RG6182 DMGO3RK Phase 1 NA [104]
RHIgM22 DM7D4EP Phase 1 NA [20]
RPI-78M DMXKFOQ Phase 1 NA [20]
RTL-1000 DM1B4CQ Phase 1 NA [105]
RTL1000 DM32K8B Phase 1 NA [106]
OMB157 DM05R2X Clinical trial NA [20]
PMID10498202C1 DMXE0F2 Clinical trial Small molecular drug [107]
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⏷ Show the Full List of 92 Drug(s)
This Disease is Treated as An Indication in 5 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
PMID27998201-Compound-5 DMVZ0ND Patented Small molecular drug [108]
Quinazoline derivative 10 DMZ3ORT Patented Small molecular drug [109]
Quinazoline derivative 11 DMAH435 Patented Small molecular drug [109]
Quinazoline derivative 12 DMVKZU2 Patented Small molecular drug [109]
Quinazoline derivative 13 DMFU6OD Patented Small molecular drug [109]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 19 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
MBP(82-98) DM9A87P Discontinued in Phase 3 NA [110]
SC-124a DMLLJ6P Discontinued in Phase 3 NA [111]
AnergiX.MS DM8K9MY Discontinued in Phase 2 NA [112]
Daxalipram DMXO9BQ Discontinued in Phase 2 NA [113]
IMM-308 DMGFVIB Discontinued in Phase 2 NA [114]
NTx-488 DMX9KYW Discontinued in Phase 2 NA [115]
Apogen MS DMBH0U3 Discontinued in Phase 1 NA [116]
AZD-4750 DMQ2VYT Discontinued in Phase 1 NA [117]
AZD5904 DM8SCON Discontinued in Phase 1 Small molecular drug [118]
CCX915 DMHMST3 Discontinued in Phase 1 Small molecular drug [119]
INCB8696 DM8PTUC Discontinued in Phase 1 NA [120]
REN-850 DMGZRO2 Discontinued in Phase 1 NA [121]
TR-14035 DMWD39E Discontinued in Phase 1 Small molecular drug [122]
ZD-7349 DM1EB6H Discontinued in Phase 1 NA [123]
BB-1101 DM7GH5Z Terminated Small molecular drug [129]
CYT-017-IL17Qb DM3G7KA Terminated NA [130]
METHYLTHIOADENOSINE DMC8J6F Terminated Small molecular drug [131]
MMS-255 DMA138C Terminated NA [132]
PA-1093 DM0X9WK Terminated NA [133]
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⏷ Show the Full List of 19 Drug(s)
This Disease is Treated as An Indication in 5 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AEOL-10150 DM13YRT Preclinical NA [124]
SR-1001 DM8MYKL Preclinical NA [125]
TFM735 DMY8QP5 Preclinical Small molecular drug [126]
TV-1390 DMB7WEY Preclinical NA [127]
VCB101 DMUO6XC Preclinical Small molecular drug [128]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 28 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ATX-MS2 DMECQXA Investigative NA [125]
ATX-MS3 DMABWJJ Investigative NA [125]
BBT-032 DM4QE0K Investigative NA [125]
Beta-Gly DMF8JLS Investigative NA [125]
Beta-interferon DM25IMM Investigative NA [125]
BVA-101 DM5R1TT Investigative NA [125]
BVA-201 DMXX40I Investigative NA [125]
Estriol E3 DMNXO9C Investigative NA [134]
IFN-beta-CTP DMTW8OI Investigative NA [125]
LAS-189913 DMT7M60 Investigative NA [125]
Long-acting interferon beta conjugate DMSJD3K Investigative NA [125]
MCT-175 DMF11KP Investigative NA [125]
MIQ-003 DMHPQFX Investigative NA [125]
MyeloXen DMDMT10 Investigative NA [125]
NeurArrest DMCURNT Investigative NA [125]
Neurotrophic factor-producing stem cells DM52RHM Investigative NA [125]
NIBR-785 DMU0BMQ Investigative Small molecular drug [135]
NNZ-4921 DMMIK2Q Investigative NA [125]
NOGGIN DMS82AD Investigative NA [125]
NU-400 DMC2RBR Investigative NA [125]
P-1104 DMUCIMP Investigative NA [125]
PV-267 DMC1SZT Investigative Small molecular drug [125]
RGI-4100 DM7G0M3 Investigative NA [125]
RVX-297 DMO60MA Investigative NA [125]
SOM-0999 DMH3078 Investigative NA [125]
TNFR1 NAM DMPTQEG Investigative NA [136]
TX-MSD DMKY78A Investigative NA [125]
Unsaturated long chain fatty acids DME2JHI Investigative NA [125]
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⏷ Show the Full List of 28 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 410 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
BLK TTNDSC3 Limited Genetic Variation [137]
BMP1 TT0L58T Limited Biomarker [138]
C3AR1 TTI6B3F Limited Biomarker [139]
CCR8 TTE836A Limited Altered Expression [140]
CEACAM3 TTPX7I5 Limited Biomarker [141]
CNTF TTGEM5Q Limited Biomarker [142]
CPB1 TT4UJX5 Limited Genetic Variation [143]
CX3CR1 TT2T98G Limited Biomarker [144]
CXCL12 TT4UGTF Limited Biomarker [145]
CXCL13 TT0NIZ1 Limited Altered Expression [146]
CXCR2 TT30C9G Limited Altered Expression [147]
CXCR3 TT1UCIJ Limited Altered Expression [148]
CYP24A1 TT82UI1 Limited Genetic Variation [149]
EBI3 TTJF68X Limited Altered Expression [150]
GABRA3 TT37EDJ Limited Genetic Variation [151]
GPR17 TTMPART Limited Biomarker [152]
HNRNPA1 TTPJ9XK Limited Biomarker [153]
ITGA1 TTPERWV Limited Biomarker [154]
ITGA4 TTJMF9P Limited Biomarker [155]
ITGAL TT48WR6 Limited Biomarker [156]
LTA TTP73TM Limited Biomarker [157]
METAP2 TTZL0OI Limited Altered Expression [158]
NCAM1 TTVXPHT Limited Biomarker [159]
NLRP1 TTQX29T Limited Biomarker [160]
PNMT TT0NZIC Limited Biomarker [161]
POMC TT21AKM Limited Biomarker [162]
PRCP TTTJZ4M Limited Biomarker [138]
PRLR TTBPXMA Limited Biomarker [163]
STAT1 TTN7R6K Limited Altered Expression [164]
TGM2 TT2F4OL Limited Biomarker [165]
TPSAB1 TTM1TDX Limited Biomarker [166]
TRB TT84HCW Limited Biomarker [167]
TYK2 TTBYWP2 Limited Biomarker [168]
ADAMTS1 TTS2TEI Disputed Altered Expression [169]
ADAMTS4 TTYG6BU Disputed Biomarker [169]
CA12 TTSYM0R Disputed Genetic Variation [170]
CA13 TTQPHSR Disputed Genetic Variation [170]
DYSF TTA7MXQ Disputed Biomarker [171]
EIF2AK2 TTXEZJ4 Disputed Biomarker [172]
GRM4 TTICZ1O Disputed Biomarker [173]
GRM8 TT0IFKL Disputed Altered Expression [173]
IL5RA TTXH9AD Disputed Genetic Variation [174]
PTAFR TTQL5VC Disputed Genetic Variation [175]
RIPK2 TTCQ2E5 Disputed Biomarker [176]
SLC1A2 TT2F078 Disputed Biomarker [177]
SLC1A3 TT8WRDA Disputed Altered Expression [177]
ALCAM TT2AFT6 moderate Biomarker [178]
CD47 TT28S46 moderate Altered Expression [179]
CD6 TTMF6KC moderate Genetic Variation [180]
CFP TTLA0VS moderate Biomarker [181]
HLA-B TTGS10J moderate Genetic Variation [182]
IFNAR2 TTMQB37 moderate Altered Expression [183]
LINGO1 TTZYQ80 moderate Biomarker [184]
MAPK1 TT4TQBX moderate Altered Expression [185]
NCF1 TTZ4JC3 moderate Biomarker [186]
NR1H3 TTECBXN moderate Genetic Variation [187]
P2RX4 TT1NLOA moderate Biomarker [188]
PADI4 TTQHAXM moderate Biomarker [189]
SLC2A4 TTP6MT5 moderate Altered Expression [185]
TNFAIP3 TT5W0IO moderate Genetic Variation [190]
TNFSF13 TTOI1RM moderate Biomarker [191]
TNFSF14 TTKVENM moderate Altered Expression [192]
UCP2 TTSC2YM moderate Biomarker [193]
WAS TTE8T73 moderate Biomarker [194]
ABHD6 TTSINOV Strong Biomarker [195]
ACKR1 TTKY2NS Strong Altered Expression [196]
ACO2 TTMTF2P Strong Altered Expression [197]
ADAM17 TT6AZXG Strong Altered Expression [198]
ADCYAP1 TTW4LYC Strong Biomarker [199]
AGER TTMO9HF Strong Biomarker [200]
AGTR1 TT8DBY3 Strong Altered Expression [201]
AHSG TTKF4WV Strong Biomarker [202]
AICDA TTKRTP6 Strong Biomarker [203]
AMACR TTLN1AP Strong Biomarker [204]
ANGPTL4 TTWALY5 Strong Altered Expression [205]
ANTXR2 TTOD34I Strong Biomarker [206]
AOC3 TT7HC21 Strong Biomarker [207]
ARG1 TT7ZQEV Strong Altered Expression [208]
ARG2 TTV1AG6 Strong Biomarker [209]
ASIC1 TTRJYB6 Strong Biomarker [210]
ASIC2 TTVMWLP Strong Altered Expression [211]
ATXN2 TTPQJ7P Strong Genetic Variation [212]
BCHE TT3MSAO Strong Biomarker [213]
BDKRB1 TTG5QIA Strong Altered Expression [214]
BMPR2 TTGKF90 Strong Altered Expression [215]
BRD2 TTDP48B Strong Genetic Variation [216]
BRS3 TTKYEPM Strong Genetic Variation [217]
BTLA TTER58P Strong Biomarker [218]
CACNA1H TTZPWGN Strong Genetic Variation [219]
CASP1 TTCQIBE Strong Biomarker [220]
CCL21 TTLZK1U Strong Altered Expression [221]
CCL22 TTBTWI1 Strong Genetic Variation [222]
CCL3 TT8I4WB Strong Genetic Variation [223]
CCR1 TTC24WT Strong Biomarker [224]
CCR3 TTD3XFU Strong Altered Expression [224]
CCR6 TTFDB30 Strong Biomarker [148]
CCR9 TTIPS8B Strong Biomarker [225]
CD14 TT6I7DC Strong Altered Expression [226]
CD19 TTW640A Strong Biomarker [227]
CD1A TTBGTFN Strong Genetic Variation [228]
CD200 TT0BE68 Strong Biomarker [229]
CD27 TTDO1MV Strong Biomarker [230]
CD276 TT6CQUM Strong Biomarker [231]
CD28 TTQ13FT Strong Biomarker [232]
CD4 TTN2JFW Strong Biomarker [233]
CD52 TTQT5S9 Strong Biomarker [234]
CD58 TT5KSBY Strong Biomarker [235]
CD69 TTPQE9F Strong Genetic Variation [236]
CD80 TT89Z17 Strong Genetic Variation [237]
CD83 TTT9MRQ Strong Biomarker [238]
CD86 TT53XHB Strong Genetic Variation [239]
CDC37 TT5SOEU Strong Genetic Variation [240]
CDH3 TTARMD9 Strong Genetic Variation [236]
CEACAM1 TTA9CK4 Strong Biomarker [241]
CFB TTA0P7K Strong Genetic Variation [216]
CHAT TTKYFSB Strong Genetic Variation [242]
CLEC12A TT70N8V Strong Biomarker [243]
CLIC1 TT8KZG6 Strong Biomarker [244]
CMKLR1 TT4UGZL Strong Biomarker [245]
CNP TT71P0H Strong Biomarker [246]
CNR1 TT6OEDT Strong Biomarker [247]
CNR2 TTMSFAW Strong Biomarker [248]
CNTN1 TTPR8FK Strong Biomarker [249]
CREB1 TTH4AN3 Strong Altered Expression [250]
CRTC2 TTFWETR Strong Genetic Variation [251]
CRYAB TT7RUHB Strong Biomarker [252]
CSF1R TT7MRDV Strong Altered Expression [253]
CTSE TTLXC4Q Strong Biomarker [254]
CTSH TT3G406 Strong Biomarker [255]
CXCL11 TTWG0RE Strong Biomarker [256]
CXCL2 TTZF0K2 Strong Altered Expression [257]
CXCL9 TTWE5PB Strong Biomarker [256]
CXCR1 TTMWT8Z Strong Altered Expression [258]
CXCR5 TTIW59R Strong Genetic Variation [259]
CYP21A2 TTP4GLG Strong Genetic Variation [260]
CYP2C9 TTR40YJ Strong Genetic Variation [261]
CYP46A1 TT4EB85 Strong Altered Expression [262]
DDIT4 TTVEOY6 Strong Altered Expression [263]
DHCR24 TTTK0NH Strong Biomarker [264]
DHODH TTLVP78 Strong Biomarker [265]
DLK1 TTF4AVB Strong Biomarker [266]
DLL1 TT9CFQD Strong Biomarker [267]
DNASE1 TTYWGOJ Strong Genetic Variation [268]
DPYSL2 TTZCW3T Strong Posttranslational Modification [269]
EGFL7 TT7WD0H Strong Biomarker [270]
EHMT2 TTS6RZT Strong Genetic Variation [260]
EIF2AK1 TTRUJBV Strong Genetic Variation [219]
EIF2AK3 TT79U1M Strong Altered Expression [271]
EIF4EBP2 TTNBTCW Strong Altered Expression [272]
ENPP2 TTSCIM2 Strong Biomarker [273]
ERAP1 TT60XFL Strong Genetic Variation [274]
ERBB3 TTSINU2 Strong Biomarker [275]
ETS1 TTTGPSD Strong Genetic Variation [236]
F2RL1 TTQR74A Strong Biomarker [276]
FCGR1A TTZK4I3 Strong Altered Expression [277]
FCGR3A TTIFOC0 Strong Altered Expression [278]
FDXR TT3W4IX Strong Altered Expression [279]
FES TTLBY21 Strong Biomarker [280]
FGF23 TT2IZ4K Strong Biomarker [281]
FNTB TT7WZIJ Strong Altered Expression [282]
FOLR2 TTT54CI Strong Biomarker [283]
FOXC2 TTLBAP1 Strong Biomarker [284]
FOXP1 TT0MUCI Strong Genetic Variation [236]
FOXP3 TT1X3QF Strong Biomarker [285]
FYN TT2B9KF Strong Biomarker [286]
GAD1 TTKGEP3 Strong Biomarker [287]
GAD2 TT7UY6K Strong Biomarker [288]
GAL TTXZAJ5 Strong Biomarker [217]
GALC TT5IZRB Strong Genetic Variation [289]
GALR2 TTBPW3J Strong Biomarker [217]
GAP43 TTSGLN5 Strong Biomarker [290]
GAPDH TTUGSWA Strong Biomarker [291]
GAS6 TT69QD2 Strong Biomarker [292]
GFAP TTI6FFX Strong Biomarker [293]
GJB1 TTSJIRP Strong Altered Expression [294]
GJC2 TTPOCAL Strong Biomarker [295]
GLA TTIS03D Strong Altered Expression [296]
GPBAR1 TTSDVTR Strong Biomarker [297]
GPR183 TTME5YJ Strong Biomarker [298]
GPRC6A TTI1PRE Strong Altered Expression [299]
GRIA2 TTWM461 Strong Biomarker [291]
GRIA3 TT82EZV Strong Biomarker [300]
GRIA4 TTPJR0G Strong Biomarker [300]
GRIN2B TTN9D8E Strong Genetic Variation [301]
GRM3 TT8A9EF Strong Biomarker [300]
GRM7 TT0I76D Strong Biomarker [302]
GSTO1 TTWO3SH Strong Biomarker [303]
HBB TTM6HK1 Strong Biomarker [304]
HCAR2 TTWNV8U Strong Biomarker [305]
HLA-DQB2 TTL7VOU Strong Genetic Variation [216]
HNMT TT2B6EV Strong Biomarker [306]
HRH1 TTTIBOJ Strong Altered Expression [307]
HRH3 TT9JNIC Strong Genetic Variation [308]
HRH4 TTXJ178 Strong Altered Expression [307]
HSD17B13 TTDJYZR Strong Biomarker [309]
HSPB8 TTY0OJN Strong Biomarker [310]
HTATIP2 TTC6IX5 Strong Altered Expression [311]
ICA1 TTMX06B Strong Altered Expression [312]
ICOS TTE5VP6 Strong Genetic Variation [212]
ICOSLG TTB9Z8R Strong Genetic Variation [212]
IDO1 TTZJYKH Strong Altered Expression [313]
IFNGR2 TT13TL0 Strong Genetic Variation [236]
IKZF3 TTCZVFZ Strong Genetic Variation [314]
IL10RB TTJTRMK Strong Altered Expression [315]
IL13 TT0GVCH Strong Biomarker [316]
IL15 TTJFA35 Strong Altered Expression [317]
IL17D TTC5LTG Strong Biomarker [318]
IL17F TT2B6PS Strong Genetic Variation [319]
IL22 TTLDX4N Strong Biomarker [320]
IL25 TTVMO5W Strong Biomarker [321]
IL2RB TT9721Y Strong Genetic Variation [212]
IL33 TT5MD4P Strong Genetic Variation [322]
IL37 TTQTX98 Strong Biomarker [323]
IL9 TT0JTFD Strong Biomarker [324]
IRAK1 TTXAJWN Strong Genetic Variation [325]
ITCH TT5SEWD Strong Altered Expression [326]
ITGAM TTB69FJ Strong Biomarker [327]
ITPR3 TTH1769 Strong Genetic Variation [328]
KCNA3 TTY3UE6 Strong Biomarker [329]
KCNJ10 TTG140O Strong Biomarker [330]
KCNK3 TTGR91N Strong Biomarker [331]
KCNMA1 TTE87WJ Strong Genetic Variation [216]
KIR2DL2 TTU0P73 Strong Altered Expression [332]
KIR2DL3 TTEX3SI Strong Biomarker [333]
KLKB1 TTN0PCX Strong Biomarker [334]
KLRK1 TTLRN4A Strong Biomarker [335]
L3MBTL3 TTQDMJN Strong Genetic Variation [336]
LAG3 TTNVXAW Strong Biomarker [225]
LAIR1 TTSI7A8 Strong Biomarker [337]
LALBA TTBRLU3 Strong Biomarker [338]
LAMC2 TTNS7H3 Strong Genetic Variation [339]
LANCL1 TTZW8NS Strong Biomarker [340]
LBP TTVQJLY Strong Genetic Variation [341]
LIF TTGZ5WN Strong Biomarker [342]
LILRB2 TTHC6XU Strong Biomarker [343]
LILRB4 TTREOKA Strong Biomarker [343]
LPAR3 TTE2YJR Strong Altered Expression [299]
LRP2 TTPH1AJ Strong Genetic Variation [344]
LRRK2 TTK0FEA Strong Genetic Variation [212]
MALT1 TTCI81G Strong Biomarker [345]
MARK3 TT3DCYJ Strong Biomarker [346]
MAS1 TTOISYB Strong Biomarker [347]
MAZ TT059DA Strong Genetic Variation [348]
MBTPS1 TTNSM2I Strong Biomarker [349]
MC1R TT0MV2T Strong Genetic Variation [219]
MC4R TTD0CIQ Strong Altered Expression [350]
MCAM TTHRE05 Strong Biomarker [351]
MERTK TTO7LKR Strong Biomarker [352]
MGAT1 TTYJRN5 Strong Genetic Variation [353]
MLANA TT362RB Strong Genetic Variation [212]
MMP12 TTXZ0KQ Strong Altered Expression [354]
MPO TTVCZPI Strong Biomarker [355]
MRGPRX1 TTIX6PK Strong Altered Expression [299]
MS4A1 TTUE541 Strong Biomarker [191]
MST1R TTBQ3OC Strong Altered Expression [356]
MTNR1B TT32JK8 Strong Genetic Variation [357]
NCR1 TTQNRJM Strong Altered Expression [358]
NFKB2 TTKLNRV Strong Biomarker [359]
NLRP3 TT4EN8X Strong Biomarker [360]
NLRX1 TTKT026 Strong Biomarker [361]
NNT TTKIH76 Strong Altered Expression [362]
NOTCH3 TTVX7IA Strong Genetic Variation [363]
NOTCH4 TTXDIK2 Strong Genetic Variation [364]
NPEPPS TT371QC Strong Genetic Variation [365]
NR3C2 TT26PHO Strong Biomarker [366]
NTF3 TTZHKV9 Strong Altered Expression [367]
NTN1 TT0AH4L Strong Biomarker [368]
OXER1 TT7WBSV Strong Altered Expression [299]
P2RX1 TTJW7B3 Strong Altered Expression [369]
P2RX3 TT2THBD Strong Altered Expression [369]
P2RX7 TT473XN Strong Biomarker [188]
P2RY1 TTA93TL Strong Altered Expression [369]
P2RY2 TTOZHQC Strong Altered Expression [369]
PCSK1 TTED9LZ Strong Biomarker [370]
PDCD1 TTNBFWK Strong Genetic Variation [371]
PDE4B TTVIAT9 Strong Genetic Variation [372]
PDE7A TT1BC3A Strong Biomarker [373]
PHB TT6U071 Strong Altered Expression [374]
PHGDH TT8DRCK Strong Genetic Variation [236]
PLA2G4A TTT1JVS Strong Biomarker [375]
PLD1 TT3T17P Strong Altered Expression [376]
PLTP TTZF6SN Strong Biomarker [273]
PMEL TT8MK59 Strong Biomarker [359]
PML TTLH9NY Strong Genetic Variation [377]
PROC TTZUXYS Strong Biomarker [378]
PSEN1 TTZ3S8C Strong Genetic Variation [379]
PSMB6 TT8EPLT Strong Biomarker [267]
PSMD10 TT2H4LN Strong Biomarker [303]
PTGER4 TT79WV3 Strong Biomarker [380]
PTGES TTYLQ8V Strong Biomarker [381]
PTPN2 TTY8PUS Strong Biomarker [382]
RARA TTW38KT Strong Altered Expression [383]
RBPJ TT72D4Z Strong Biomarker [384]
REL TT1ZCTH Strong Altered Expression [385]
RGMA TTURJV4 Strong Biomarker [386]
RIPK1 TTVJHX8 Strong Biomarker [370]
RNASEL TT7V0K4 Strong Genetic Variation [387]
RNF6 TT4S09X Strong Biomarker [388]
RORA TT1TYN7 Strong Genetic Variation [389]
ROS1 TTSZ6Y3 Strong Biomarker [390]
RPS6KB1 TTG0U4H Strong Genetic Variation [391]
RPSA TTLUW5B Strong Biomarker [340]
RTN4R TTVRZUO Strong Biomarker [392]
S100B TTQ0V86 Strong Biomarker [393]
S1PR1 TT9JZCK Strong Biomarker [394]
S1PR2 TTVSMOH Strong Altered Expression [395]
S1PR3 TTDYP7I Strong Biomarker [396]
SCN10A TT90XZ8 Strong Genetic Variation [397]
SELE TT1PL7M Strong Biomarker [398]
SEMA3A TTVKD3S Strong Biomarker [399]
SERPINA1 TTA7UJC Strong Genetic Variation [273]
SERPING1 TTVQ6R9 Strong Biomarker [400]
SGCG TTSMT9W Strong Biomarker [401]
SGK1 TTTV8EJ Strong Biomarker [402]
SGPL1 TT618Q2 Strong Biomarker [403]
SLAMF7 TT7ILZ1 Strong Genetic Variation [236]
SLC15A2 TT27Q3A Strong Genetic Variation [328]
SLC16A1 TTN1J82 Strong Biomarker [404]
SLC16A3 TTG6VD5 Strong Altered Expression [405]
SLC1A1 TTG2A6F Strong Biomarker [406]
SLC25A4 TTU5A6Q Strong Biomarker [407]
SLC40A1 TT6Y1PG Strong Genetic Variation [408]
SLC44A4 TT0NYDG Strong Genetic Variation [260]
SLC7A11 TTBZMIO Strong Altered Expression [409]
SMPD1 TTJTM88 Strong Biomarker [410]
SNAP25 TTYQWA0 Strong Genetic Variation [411]
SOCS1 TT8COJM Strong Altered Expression [412]
SORT1 TTRX9AV Strong Altered Expression [413]
SPHK1 TTOHFIY Strong Biomarker [414]
SPHK2 TTCN0M9 Strong Biomarker [415]
SSRP1 TTETDKQ Strong Biomarker [416]
SYVN1 TT8XKYM Strong Biomarker [417]
TCIRG1 TTVRN05 Strong Biomarker [418]
TDO2 TTXNCBV Strong Biomarker [419]
TGFB3 TTWOMY8 Strong Altered Expression [420]
TH TTUHP71 Strong Altered Expression [421]
THBS1 TTKI0H1 Strong Altered Expression [422]
TIGIT TTWNL74 Strong Altered Expression [423]
TLN1 TTQSMFG Strong Altered Expression [424]
TLR2 TTY7ZHS Strong Biomarker [425]
TLR7 TTRJ1K4 Strong Altered Expression [426]
TLR8 TT8CWFK Strong Biomarker [427]
TMPRSS6 TTL9KE7 Strong Genetic Variation [428]
TNFRSF12A TTKPS7V Strong Biomarker [429]
TNFRSF13C TT7NJSE Strong Biomarker [430]
TNFRSF25 TTDV6BQ Strong Biomarker [244]
TNFRSF4 TTL31H0 Strong Altered Expression [431]
TNFSF12 TTBTDM1 Strong Altered Expression [432]
TNFSF13B TTWMIDN Strong Biomarker [433]
TNFSF15 TTEST6I Strong Altered Expression [434]
TOR1A TTF85KW Strong Genetic Variation [435]
TPH2 TT3KLDP Strong Genetic Variation [357]
TPP2 TTQ7R2V Strong Genetic Variation [436]
TPX2 TT0PHL4 Strong Biomarker [359]
TRAF6 TTCDR6M Strong Biomarker [437]
TRPM2 TTEBMN7 Strong Biomarker [438]
TRPM8 TTXDKTO Strong Biomarker [439]
TSPO TTPTXIN Strong Biomarker [440]
TXNRD1 TTR7UJ3 Strong Biomarker [441]
TYRO3 TTIEMFN Strong Biomarker [442]
UBC TTBP3XA Strong Biomarker [286]
VCAM1 TTHCEF6 Strong Biomarker [443]
WNK1 TTJ9UMX Strong Altered Expression [444]
ZFP36L1 TT8QVJO Strong Genetic Variation [236]
BACE1 TTJUNZF Definitive Biomarker [445]
BIRC2 TTQ5LRD Definitive Biomarker [446]
BTG1 TTL7N2W Definitive Genetic Variation [447]
CCL17 TTMPHAE Definitive Genetic Variation [222]
CCL20 TT2XAZY Definitive Genetic Variation [319]
CCR4 TT7HQD0 Definitive Biomarker [448]
CFH TTUW6OP Definitive Biomarker [449]
CHIT1 TTDYX6T Definitive Altered Expression [450]
CRHR1 TT7EFHR Definitive Biomarker [451]
CRYZ TTP6UO8 Definitive Biomarker [452]
DLL4 TTV23LH Definitive Biomarker [453]
DPP4 TTDIGC1 Definitive Biomarker [454]
ENTPD1 TTYM8DJ Definitive Biomarker [455]
GLO1 TTV9A7R Definitive Genetic Variation [456]
GPR3 TTHZVSK Definitive Altered Expression [457]
GRM1 TTVBPDM Definitive Biomarker [458]
GRN TT0LWE3 Definitive Altered Expression [459]
IL11 TTGUYTR Definitive Biomarker [460]
IL12A TTRTK6Y Definitive Biomarker [236]
IL12RB2 TT4SWR8 Definitive Altered Expression [461]
IL21R TTZO9B0 Definitive Altered Expression [462]
IL5 TTPREZD Definitive Altered Expression [463]
KIF5A TTCJPAH Definitive Genetic Variation [464]
KIR2DL1 TT4UXPE Definitive Genetic Variation [465]
KLK6 TTLPF4X Definitive Biomarker [466]
MASP2 TTR01E9 Definitive Altered Expression [467]
MYD88 TTB6Q2O Definitive Altered Expression [385]
NR0B2 TT25A9Q Definitive Biomarker [468]
NR3C1 TTOZRK6 Definitive Genetic Variation [469]
NR4A1 TTMXE2Q Definitive Biomarker [470]
NR4A3 TTJQB49 Definitive Biomarker [471]
P2RY12 TTZ1DT0 Definitive Biomarker [472]
PRKCA TTFJ8Q1 Definitive Biomarker [473]
PRKCE TT57MT2 Definitive Biomarker [474]
PSMB9 TTOUSTQ Definitive Genetic Variation [475]
PTPN6 TT369M5 Definitive Biomarker [468]
RTN4 TT7GXMU Definitive Biomarker [476]
SCN8A TT54ERL Definitive Altered Expression [477]
SDC1 TTYDSVG Definitive Biomarker [478]
SELPLG TTS5K8U Definitive Biomarker [479]
TKT TT04R7I Definitive Biomarker [246]
TLR3 TTD24Y0 Definitive Biomarker [480]
TNFRSF14 TTWGTC1 Definitive Genetic Variation [481]
TNFRSF17 TTZ3P4W Definitive Altered Expression [482]
TREM2 TTQRMSJ Definitive Biomarker [483]
XRCC5 TTCB9KW Definitive Genetic Variation [484]
------------------------------------------------------------------------------------
⏷ Show the Full List of 410 DTT(s)
This Disease Is Related to 15 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA7 DTDVSJA Disputed Genetic Variation [485]
SLC52A1 DT7NOKR Disputed Altered Expression [486]
SLC9A9 DT8LP62 moderate Genetic Variation [487]
SLC16A2 DTQ8MP1 Strong Biomarker [488]
SLC25A14 DTHSNUW Strong Biomarker [193]
SLC25A20 DTQOUM4 Strong Genetic Variation [259]
SLC25A37 DTLBGTZ Strong Biomarker [489]
SLC30A3 DTKMECW Strong Biomarker [490]
SLC30A7 DTQK38X Strong Genetic Variation [240]
SLC44A2 DTSF91X Strong Genetic Variation [236]
SLC9A8 DTNY0C2 Strong Genetic Variation [236]
SLCO6A1 DTIFXNS Strong Altered Expression [491]
SLC1A4 DTC54PX Definitive Altered Expression [492]
SLC25A27 DT0HW5C Definitive Genetic Variation [493]
SLC25A36 DTANQH4 Definitive Genetic Variation [494]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 DTP(s)
This Disease Is Related to 21 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
DHCR7 DEL7GFA Limited Genetic Variation [495]
PGPEP1 DEVDR46 Limited Biomarker [138]
TPMT DEFQ8VO Disputed Genetic Variation [496]
HPRT1 DEVXTP5 moderate Biomarker [497]
ASMT DEHGR57 Strong Altered Expression [498]
CYP27A1 DEBS639 Strong Genetic Variation [499]
CYP2R1 DEBIHM3 Strong Genetic Variation [500]
CYP7A1 DEDZRQ1 Strong Genetic Variation [501]
CYP7B1 DE36TMY Strong Genetic Variation [502]
DDAH1 DEY0TQC Strong Genetic Variation [236]
GGCT DEKW6PB Strong Altered Expression [503]
HSD17B7 DEDMWFX Strong Biomarker [309]
MANBA DEMH6UB Strong Genetic Variation [240]
MMEL1 DEYCUQ2 Strong Genetic Variation [504]
MT2A DEFKGT7 Strong Biomarker [505]
NAT1 DE7OAB3 Strong Biomarker [506]
PARK7 DEPOVCH Strong Altered Expression [507]
PON2 DEHJU7E Strong Genetic Variation [508]
TGM6 DEUWCVD Strong Altered Expression [509]
GANAB DEMWKYT Definitive Biomarker [510]
PCK1 DEPLH5Z Definitive Genetic Variation [511]
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 DME(s)
This Disease Is Related to 581 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADRM1 OTOU4EY6 Limited Biomarker [512]
ATXN7 OTL3YF1H Limited Genetic Variation [513]
BCL10 OT47MCLI Limited Biomarker [514]
BMP5 OTC0Y6E0 Limited Altered Expression [515]
CCN3 OTOW5YL4 Limited Biomarker [516]
CD177 OTS79FNF Limited Biomarker [517]
CD1B OT4D5EG7 Limited Altered Expression [518]
CD226 OT4UG0KB Limited Genetic Variation [519]
CEACAM7 OTKFDTZY Limited Biomarker [141]
CLDN11 OTNN6UTL Limited Altered Expression [520]
CSN2 OT22C0PD Limited Genetic Variation [521]
ERCC5 OTQAKFJM Limited Biomarker [522]
EVI2A OTR8RUXQ Limited Genetic Variation [523]
FAM167A OT9JF3JQ Limited Genetic Variation [137]
FANCG OT7MC8TZ Limited Biomarker [522]
GPC5 OT8NR7GC Limited Genetic Variation [524]
HCCS OTQE88BE Limited Genetic Variation [525]
HLA-DRA OT7KZMP2 Limited Genetic Variation [526]
HMCES OTVRDL6U Limited Biomarker [527]
HSPA14 OTZCA5LK Limited Altered Expression [528]
IL17C OTKXIVNQ Limited Altered Expression [529]
IL18R1 OT83XMPQ Limited Altered Expression [150]
KIF1B OTI1XQTO Limited Altered Expression [530]
MAP2 OT6UYT3X Limited Altered Expression [158]
NINJ1 OTLRZ1EU Limited Biomarker [522]
NPHS1 OT21JD3P Limited Biomarker [531]
NXF1 OTEFHXG6 Limited Biomarker [532]
PLXNA2 OTNNBJMQ Limited Genetic Variation [533]
PSG2 OT2EIXAI Limited Biomarker [141]
PTPRCAP OT2YERNV Limited Genetic Variation [534]
RFX1 OTZUDMPR Limited Altered Expression [535]
RPS4X OTIH80EK Limited Biomarker [522]
SARS1 OTFKXQ1O Limited Biomarker [536]
SARS2 OTU4T99W Limited Biomarker [536]
SPAST OTIF3AJI Limited Genetic Variation [537]
STAT4 OTAK3VFR Limited Biomarker [538]
STK17B OT4NYNO8 Limited Biomarker [539]
TFDP3 OTI4K6MN Limited Altered Expression [540]
ADAMTS14 OTFJ1PDB Disputed Biomarker [541]
ADAMTS3 OT2U6VF5 Disputed Biomarker [169]
ATP8 OTYQQR53 Disputed Genetic Variation [542]
BAG4 OTUPX3M2 Disputed Altered Expression [176]
CCL15 OTOGZ85M Disputed Genetic Variation [223]
CHAF1A OTXSSY4H Disputed Biomarker [543]
DAXX OTX6O7PL Disputed Altered Expression [176]
DLG5 OTU9Z17K Disputed Genetic Variation [544]
DST OTHZBM4X Disputed Genetic Variation [545]
EBF1 OTZ61YYH Disputed Genetic Variation [546]
IFNGR1 OTCTQBWW Disputed Genetic Variation [547]
KLC1 OTSTTTW7 Disputed Genetic Variation [548]
KLHL7 OT2OF1O8 Disputed Biomarker [549]
LY6E OTMG16BZ Disputed Genetic Variation [550]
POU2AF1 OTOO6WHL Disputed Biomarker [551]
PRSS3 OTN3S5YB Disputed Biomarker [552]
TNFSF9 OTV9L89D Disputed Altered Expression [553]
TPI1 OT14KP4B Disputed Biomarker [554]
ATG5 OT4T5SMS moderate Biomarker [555]
EVI5 OTOPAP55 moderate Genetic Variation [556]
HFE OTDD93KB moderate Genetic Variation [408]
HOXB4 OTH1HRW5 moderate Altered Expression [557]
IFIH1 OTZA2AHA moderate Genetic Variation [558]
IL6ST OT1N9C70 moderate Biomarker [150]
KL OTD4VWU6 moderate Biomarker [559]
LRCH1 OT0RCL85 moderate Biomarker [560]
LRPPRC OTXSK5LP moderate Biomarker [561]
MOK OTQK7M9V moderate Biomarker [200]
OPN1MW OTPJ7LX4 moderate Biomarker [562]
PADI2 OTT40K94 moderate Biomarker [563]
RGCC OTYJMLWM moderate Biomarker [564]
ABCG4 OT2XJIOG Strong Biomarker [565]
ACAD8 OT3JI5GB Strong Biomarker [566]
ACKR2 OTWYY14H Strong Altered Expression [567]
ACOT7 OT7C68YV Strong Biomarker [568]
ACTBL2 OTD6B81U Strong Biomarker [568]
ACTG2 OTRDWUO0 Strong Biomarker [568]
ADGRA2 OTBT4W36 Strong Biomarker [569]
ADGRG1 OTQBB8NT Strong Altered Expression [472]
ADGRG6 OTY2UBXO Strong Biomarker [569]
AFF3 OTR0705Z Strong Genetic Variation [212]
AGA OTNWT1WB Strong Genetic Variation [570]
AGAP2 OTEYO9TM Strong Genetic Variation [240]
AGBL2 OTCX9987 Strong Genetic Variation [236]
AHI1 OT8K2YWY Strong Genetic Variation [571]
AHRR OTSJ12W6 Strong Altered Expression [572]
AIM2 OT86QUI8 Strong Biomarker [573]
AIRE OTA7G1Y1 Strong Biomarker [574]
AK5 OTTGXLOT Strong Genetic Variation [216]
ALKBH1 OTADGU5D Strong Biomarker [575]
AMBRA1 OTY0YGT9 Strong Biomarker [576]
AMIGO2 OTPAIT1O Strong Biomarker [577]
AMT OTQYEWZQ Strong Biomarker [578]
ANKRD55 OT62KZII Strong Genetic Variation [579]
ANO2 OT650E98 Strong Biomarker [580]
ANP32B OT3SQMLU Strong Altered Expression [581]
APCDD1 OTV9AD0L Strong Altered Expression [582]
APOC2 OTLINYIQ Strong Altered Expression [583]
ARHGAP31 OTUYTF4I Strong Genetic Variation [212]
ARHGEF10 OTHJ1Y4I Strong Genetic Variation [387]
ARMH1 OTTJC0D6 Strong Biomarker [340]
ARNT2 OTAQD3YV Strong Altered Expression [584]
ARSF OTC0L12N Strong Biomarker [585]
ASCC2 OT3B204T Strong Biomarker [359]
ASCL2 OT3D62WB Strong Genetic Variation [586]
ASF1B OTKXX12I Strong Biomarker [587]
ATF7IP OTU6ZA7F Strong Altered Expression [422]
ATG12 OTJRO09Y Strong Biomarker [588]
ATG16L1 OTEOYC5D Strong Genetic Variation [212]
ATG16L2 OTJYU0W8 Strong Biomarker [588]
ATP2B2 OT1NPZ9T Strong Altered Expression [589]
ATP6 OTPHOGLX Strong Genetic Variation [590]
ATP6AP2 OT0IABVV Strong Biomarker [591]
ATXN2L OTP5M3R9 Strong Genetic Variation [212]
B4GALT6 OTBM8F2U Strong Altered Expression [592]
BACH2 OT17GS18 Strong Genetic Variation [236]
BAG6 OT4Z0S2U Strong Genetic Variation [260]
BANK1 OTXAAA11 Strong Genetic Variation [212]
BATF OT9VSD2D Strong Genetic Variation [240]
BCAP31 OTKSACR4 Strong Biomarker [303]
BCL3 OT1M5B95 Strong Biomarker [593]
BTNL2 OTTTEMZA Strong Genetic Variation [594]
C1D OTI9PMN1 Strong Altered Expression [278]
C1orf141 OTASPHL0 Strong Genetic Variation [212]
C1QA OT6XKVVA Strong Altered Expression [595]
C1QTNF3 OTOJMWW0 Strong Altered Expression [596]
C1QTNF6 OT57EPQC Strong Genetic Variation [212]
C1QTNF9 OTLI3VA3 Strong Altered Expression [596]
C2 OTHMF4YM Strong Genetic Variation [216]
CAMKMT OTLJBRUW Strong Genetic Variation [597]
CANX OTYP1F6J Strong Biomarker [598]
CARD11 OTRCTLYC Strong Genetic Variation [268]
CARD16 OT4NUHWB Strong Biomarker [599]
CBLIF OTNE20WU Strong Biomarker [600]
CCDC134 OT70OQQV Strong Altered Expression [601]
CCL1 OT23NON8 Strong Biomarker [602]
CCL26 OT2B7HR9 Strong Biomarker [603]
CCL27 OTUZYC61 Strong Biomarker [604]
CD1D OT3ROU4J Strong Biomarker [605]
CD1E OT4F3AKI Strong Genetic Variation [228]
CD200R1 OT65Q9M6 Strong Biomarker [606]
CD300LF OTQWJGSR Strong Altered Expression [607]
CD48 OT83ZNPP Strong Altered Expression [608]
CD8A OTDWQJXK Strong Biomarker [233]
CDCP1 OTD7RRWK Strong Biomarker [609]
CDH17 OT9EV2XK Strong Genetic Variation [610]
CDKAL1 OTA0SGNE Strong Genetic Variation [212]
CDR2 OTD3ZJST Strong Biomarker [611]
CDSN OTQW4HV6 Strong Genetic Variation [216]
CELF1 OT6JQ5RS Strong Altered Expression [612]
CEMIP OTK80FYN Strong Altered Expression [613]
CENPO OTXAH83Y Strong Genetic Variation [236]
CERS2 OTRAHYYP Strong Biomarker [614]
CERS6 OTOP4GV1 Strong Altered Expression [615]
CETN1 OTGQ8JOZ Strong Altered Expression [616]
CH25H OT9S2BSW Strong Genetic Variation [617]
CHGB OT7SAQT2 Strong Altered Expression [618]
CHI3L1 OT2Z7VJH Strong Biomarker [619]
CIC OTFXCHNZ Strong Biomarker [620]
CISH OT8T5NYL Strong Biomarker [621]
CLDN3 OT71MN9S Strong Biomarker [622]
CLDN5 OTUX60YO Strong Biomarker [623]
CLEC11A OT9KBH7C Strong Altered Expression [624]
CLEC16A OTLGV5SV Strong Genetic Variation [625]
CLEC4D OTT7X1UC Strong Biomarker [626]
CLEC4E OT7P8ICY Strong Biomarker [626]
CLSTN2 OT2PJYHX Strong Genetic Variation [594]
CNN3 OTJTAXAP Strong Biomarker [627]
CNTNAP1 OT5Y03EU Strong Biomarker [249]
CNTNAP2 OT48T2ZP Strong Biomarker [628]
COL17A1 OTID5AH2 Strong Biomarker [629]
COLEC12 OTIQTK9G Strong Biomarker [630]
COP1 OT6J2K12 Strong Biomarker [599]
CPT1A OTI862QH Strong Biomarker [631]
CRYGD OTW29JC4 Strong Genetic Variation [632]
CSGALNACT1 OTBML9D9 Strong Altered Expression [633]
CSGALNACT2 OT2SH7HJ Strong Genetic Variation [236]
CST7 OTQWZUVQ Strong Altered Expression [634]
CSTF2 OTR6G4II Strong Biomarker [635]
CTNNA3 OT9Z0P1E Strong Genetic Variation [216]
CTSZ OTSCX2LL Strong Biomarker [636]
CUX2 OTDJTQAJ Strong Altered Expression [637]
CXCL16 OTD49T9R Strong Genetic Variation [638]
DDT OTF5HTYL Strong Biomarker [639]
DDX39B OTEVCFVU Strong Genetic Variation [640]
DEFB103B OT8RWY64 Strong Biomarker [641]
DESI2 OTHUOKOC Strong Biomarker [642]
DEXI OT60W9CN Strong Genetic Variation [643]
DGCR8 OT62LXE4 Strong Biomarker [644]
DHRS11 OTU3J0ZL Strong Biomarker [309]
DHX16 OTW8KZAU Strong Genetic Variation [216]
DHX40 OTOL02QN Strong Biomarker [189]
DHX58 OT19BYB1 Strong Genetic Variation [645]
DKKL1 OTWS7DED Strong Genetic Variation [236]
DLD OT378CU9 Strong Altered Expression [646]
DMTN OTDTKPBW Strong Biomarker [647]
DNAJC5 OTCZDXAL Strong Biomarker [648]
DNALI1 OTTB3L8N Strong Biomarker [303]
DNM1L OTXK1Q1G Strong Biomarker [649]
DOCK8 OTNQLL21 Strong Altered Expression [560]
DPP6 OTWW3H0K Strong Altered Expression [650]
DSG2 OTJPB2TO Strong Biomarker [244]
DSPP OT1TYNDN Strong Altered Expression [651]
DUSP15 OTS6PQYL Strong Altered Expression [652]
EBNA1BP2 OTBRVMZH Strong Biomarker [340]
EDIL3 OTDVVNS0 Strong Altered Expression [653]
EEF1AKMT3 OTHEOKZC Strong Biomarker [654]
EIF2B5 OTV3R4RB Strong Biomarker [655]
ELL3 OTALC1YD Strong Biomarker [656]
ELMO1 OTY2ORXK Strong Genetic Variation [236]
EP400 OTVQ75NX Strong Altered Expression [657]
EPS15L1 OTTFPZY2 Strong Genetic Variation [236]
ERG OTOTX9VU Strong Genetic Variation [336]
ERMN OTS3PBOH Strong Altered Expression [658]
ERVFRD-1 OT3064D7 Strong Biomarker [659]
ERVW-1 OTWV8DXJ Strong Biomarker [660]
ETFA OTXX61VZ Strong Biomarker [661]
FABP7 OTRE2H4G Strong Biomarker [662]
FAM107A OTBG61YZ Strong Genetic Variation [212]
FAM20C OTW5YZ7X Strong Genetic Variation [663]
FANCC OTTIDM3P Strong Biomarker [664]
FANCD2 OTVEB5LF Strong Genetic Variation [379]
FCGR3B OTSLSPZG Strong Altered Expression [278]
FCRL1 OTXOYT29 Strong Genetic Variation [236]
FCRL3 OTIFXFWL Strong Genetic Variation [328]
FH OTEQWU6Q Strong Biomarker [626]
FHL5 OT6C00Z1 Strong Biomarker [568]
FKBP6 OTDFQV81 Strong Genetic Variation [665]
FLOT1 OT0JPPJZ Strong Biomarker [666]
FMR1 OTWEV0T5 Strong Genetic Variation [667]
FSIP1 OTYLL6GM Strong Biomarker [309]
FZD4 OTGLZIE0 Strong Altered Expression [299]
GAS8 OT8KT2AK Strong Biomarker [668]
GBE1 OTK2N05B Strong Genetic Variation [669]
GFI1 OT9HB9H8 Strong Genetic Variation [348]
GLDN OTA8TQU9 Strong Biomarker [249]
GLIS3 OTBC960E Strong Genetic Variation [212]
GNG2 OT05Z3MC Strong Biomarker [670]
GORASP1 OTQS91S7 Strong Altered Expression [444]
GOSR1 OTX8TMVU Strong Biomarker [303]
GPR151 OT7EACU6 Strong Altered Expression [299]
GPR37 OTIMDDI3 Strong Biomarker [671]
GPR42 OTEB0ROY Strong Genetic Variation [217]
GPR65 OTCF5O4G Strong Biomarker [672]
GPX4 OTRAFFX2 Strong Altered Expression [673]
GSDMB OTWA7P10 Strong Biomarker [674]
GSDMD OTH39BKI Strong Biomarker [675]
GSTK1 OTDNGWAF Strong Altered Expression [491]
GTF2I OTUYL1TQ Strong Genetic Variation [676]
GZMA OT43R33L Strong Biomarker [244]
H2AX OT18UX57 Strong Altered Expression [677]
HACE1 OTEZULKD Strong Genetic Variation [387]
HAP1 OT6SG0JQ Strong Biomarker [678]
HBD OTRQG4WA Strong Altered Expression [679]
HCP5 OTV0YRI8 Strong Genetic Variation [216]
HELB OT769EC5 Strong Biomarker [680]
HLA-C OTV38BUJ Strong Biomarker [681]
HLA-DMB OT17HGXJ Strong Genetic Variation [216]
HLA-DQA2 OT1DH0N9 Strong Genetic Variation [216]
HLA-DRB4 OTNXIHQU Strong Genetic Variation [682]
HLA-F OT76CM19 Strong Genetic Variation [683]
HORMAD2 OTL2ENWI Strong Genetic Variation [212]
HSD17B6 OTSB55D2 Strong Biomarker [441]
HSPA1L OTC2V1K6 Strong Genetic Variation [684]
HSPA2 OTSDET7B Strong Genetic Variation [684]
HSPB6 OTFPLGZI Strong Altered Expression [310]
ICAM5 OTDGGAFH Strong Biomarker [685]
IFI30 OT9DERT1 Strong Genetic Variation [236]
IFNA1 OTPMKY0L Strong Biomarker [686]
IFNLR1 OTWWWK45 Strong Genetic Variation [687]
IGFALS OTTWCZYM Strong Genetic Variation [688]
IGSF9B OTNOMYYQ Strong Altered Expression [689]
IKZF1 OTCW1FKL Strong Biomarker [690]
IL17RA OTVVI8ER Strong Biomarker [691]
IL17REL OT0PG9GU Strong Genetic Variation [212]
IL22RA2 OTGOFDCY Strong Biomarker [692]
IL27 OTIS3OF8 Strong Biomarker [318]
IMMT OTBDSLE7 Strong Altered Expression [530]
INAVA OTGXNB86 Strong Genetic Variation [236]
INPP4B OTLROA7G Strong Genetic Variation [693]
INS-IGF2 OTZR74BO Strong Genetic Variation [212]
INSRR OT3F75WA Strong Genetic Variation [694]
IQCB1 OTYQ28V9 Strong Genetic Variation [328]
IQGAP1 OTZRWTGA Strong Genetic Variation [314]
IRF6 OTKJ44EV Strong Biomarker [695]
IRGM OTKD3O5Z Strong Genetic Variation [212]
ISG20 OTCWRJJW Strong Biomarker [696]
ITGAX OTOGIMHE Strong Biomarker [697]
ITLN1 OT7ZLJVV Strong Genetic Variation [212]
JAZF1 OTXTYSYD Strong Genetic Variation [236]
KAT8 OT5LPQTR Strong Biomarker [698]
KCNIP1 OTGLGK1R Strong Genetic Variation [625]
KCNK5 OT68V64E Strong Biomarker [699]
KIF21B OTFXFIU3 Strong Biomarker [700]
KLK10 OTD573EL Strong Biomarker [701]
KLRB1 OTQ2959Y Strong Altered Expression [702]
KLRD1 OTMYLOV4 Strong Altered Expression [358]
KRIT1 OT58AP1I Strong Genetic Variation [597]
KRT20 OT4RB40L Strong Biomarker [191]
LACC1 OT4SBHI8 Strong Genetic Variation [212]
LAD1 OT6YGTVX Strong Genetic Variation [558]
LAMA4 OTHI7TA0 Strong Biomarker [351]
LCN1 OT8BWXTV Strong Biomarker [703]
LGALS8 OT71LJ8T Strong Biomarker [704]
LGALS9 OT7MF91K Strong Biomarker [705]
LGR6 OTPZ1PWR Strong Altered Expression [299]
LILRA1 OTZ4NA7Q Strong Altered Expression [706]
LMNB1 OT100T3P Strong Biomarker [707]
LPP OT6TU8SE Strong Genetic Variation [236]
MACIR OTPSW8Y8 Strong Genetic Variation [212]
MARCHF1 OTI2EYO6 Strong Genetic Variation [708]
MASP1 OTWWCNZP Strong Biomarker [709]
MATK OTVOJJLJ Strong Biomarker [710]
MAVS OTTQ0J64 Strong Genetic Variation [645]
MB OTYWYL2D Strong Biomarker [711]
MCC OTQVI1EM Strong Biomarker [241]
MCCD1 OTLS95WO Strong Genetic Variation [216]
METTL1 OTRQC5ER Strong Biomarker [654]
MGAT5 OTU4DD4G Strong Genetic Variation [712]
MICA OTPEIEAR Strong Genetic Variation [713]
MIP OTEBLU3E Strong Biomarker [714]
MMP25 OT3BG37V Strong Biomarker [715]
MPHOSPH9 OTNUNDQN Strong Altered Expression [716]
MPP1 OTA2ENZQ Strong Genetic Variation [717]
MPV17L2 OTC08RWQ Strong Genetic Variation [240]
MRGPRX3 OTRKCCDS Strong Altered Expression [299]
MRGPRX4 OTOBHZVA Strong Altered Expression [299]
MSN OTZJ4J6G Strong Biomarker [718]
MST1 OTOC4UNG Strong Genetic Variation [212]
MX1 OT6X8G5T Strong Genetic Variation [570]
MYDGF OT9HRPL6 Strong Biomarker [318]
MYNN OT61R1HP Strong Genetic Variation [240]
MYO1C OT69L39Y Strong Biomarker [719]
MYRF OTKF6AEB Strong Altered Expression [720]
MZB1 OT071TET Strong Biomarker [199]
NAA25 OTS3QVF1 Strong Genetic Variation [212]
NAT8L OTA96AVN Strong Biomarker [721]
NCAN OT8OO6ZE Strong Genetic Variation [625]
NCOA2 OTMQFPBB Strong Genetic Variation [236]
NCOA7 OT2CNBOG Strong Altered Expression [722]
ND1 OTCLGIXV Strong Biomarker [723]
ND2 OTG9OHOX Strong Genetic Variation [724]
NDFIP1 OTIORSWF Strong Genetic Variation [236]
NDRG2 OT5L6KD7 Strong Altered Expression [725]
NEFM OT8VCBNF Strong Biomarker [726]
NELFE OTL4E94L Strong Genetic Variation [260]
NEURL3 OTA3ALQO Strong Biomarker [670]
NFASC OTBDUXZT Strong Genetic Variation [727]
NFATC2 OTK5T6HZ Strong Biomarker [728]
NFYA OTWFFOVH Strong Biomarker [678]
NHS OTKE8QAT Strong Genetic Variation [729]
NINJ2 OTUG1AOV Strong Genetic Variation [730]
NLRC4 OTAIA3NA Strong Genetic Variation [731]
NLRP5 OTLU1YML Strong Genetic Variation [219]
NOG OTGRHHPG Strong Altered Expression [732]
NOX5 OTHTH59G Strong Biomarker [733]
NRXN1 OTJN1JQA Strong Biomarker [734]
OAS3 OT6E5FYS Strong Biomarker [359]
OASL OTZ05YRP Strong Biomarker [735]
OCLN OTSUTVWL Strong Biomarker [736]
OGFOD1 OTTUQ5O3 Strong Genetic Variation [737]
OLFM3 OTBHPDTL Strong Genetic Variation [738]
OPN4 OT1LZ7TS Strong Genetic Variation [739]
OSTF1 OT8D7CDO Strong Biomarker [740]
OTUB1 OT8WWM9O Strong Biomarker [741]
OTUD3 OTHUWQHP Strong Genetic Variation [212]
P2RX2 OT0LF34A Strong Altered Expression [369]
P2RX5 OTLBR20R Strong Altered Expression [369]
P2RX6 OT1FNTXA Strong Altered Expression [369]
PANX1 OTXPEDOK Strong Biomarker [742]
PC OT6O0V51 Strong Biomarker [743]
PCBP1 OTHN0TD7 Strong Biomarker [744]
PDIK1L OTISF4KG Strong Biomarker [745]
PDLIM7 OTAZVODU Strong Biomarker [746]
PER3 OTVKYVJA Strong Genetic Variation [747]
PHEX OTG7N3J7 Strong Biomarker [748]
PHRF1 OT21KEGX Strong Genetic Variation [212]
PIK3R3 OTXGJ8N1 Strong Genetic Variation [717]
PITPNM2 OTQXF4FF Strong Genetic Variation [236]
PLEK OTB73XXA Strong Genetic Variation [212]
PLEKHG5 OTL0S21W Strong Genetic Variation [236]
PLXNA3 OTMZIBVG Strong Altered Expression [749]
POLG2 OTDBMZJB Strong Genetic Variation [717]
POLR1D OTOCZQNA Strong Biomarker [561]
POTEM OT7L2HGH Strong Biomarker [568]
POU5F1 OTDHHN7O Strong Genetic Variation [216]
PPARGC1A OTHCDQ22 Strong Biomarker [750]
PPT2 OTD5VJ9A Strong Genetic Variation [260]
PRB1 OTV0SYMD Strong Biomarker [751]
PRCC OTJ0KRYX Strong Biomarker [752]
PRDX3 OTLB2WEU Strong Biomarker [753]
PRF1 OTFVXD7H Strong Biomarker [754]
PRKD2 OTIFSVI8 Strong Genetic Variation [212]
PRKRA OTUTVZZU Strong Genetic Variation [594]
PRPF6 OT3U0ABN Strong Biomarker [407]
PRRC2A OTBX6FM5 Strong Genetic Variation [216]
PRSS16 OTVCZ5V1 Strong Altered Expression [755]
PSMD12 OTWICA51 Strong Genetic Variation [717]
PSMD4 OTH1VZTM Strong Biomarker [585]
PSMD7 OT7PZZ4K Strong Biomarker [340]
PSMG4 OTWBC4YL Strong Genetic Variation [219]
PSORS1C1 OT9HK436 Strong Genetic Variation [216]
PTGR2 OTYPYOUM Strong Biomarker [403]
PTPA OTRGFOI7 Strong Biomarker [756]
PTPN4 OT6SXU5Y Strong Genetic Variation [757]
PTPRN OTAP7NOL Strong Biomarker [312]
PUS10 OTFFJWZX Strong Genetic Variation [212]
PXK OTSP1WLK Strong Genetic Variation [212]
PXT1 OTRG82L2 Strong Genetic Variation [236]
QKI OTTAUGLB Strong Biomarker [758]
QTRT1 OTC33MCV Strong Biomarker [759]
RAB32 OTTR4H7S Strong Altered Expression [401]
RAB3GAP1 OT4DQ8F2 Strong Genetic Variation [760]
RAB40B OTCA9ZF5 Strong Altered Expression [383]
RAB4A OT7BL9WW Strong Genetic Variation [761]
RABEPK OTCZSREH Strong Biomarker [340]
RABGGTA OTYMG99C Strong Altered Expression [282]
RABGGTB OTZ25I2W Strong Altered Expression [282]
RAC2 OTAOHFNH Strong Altered Expression [272]
RASD1 OT2BAJHK Strong Biomarker [762]
RASGRP1 OTX9WN2E Strong Genetic Variation [236]
RASL12 OTNAK9X4 Strong Biomarker [763]
RELB OTU3QYEF Strong Biomarker [764]
RELN OTLKMW1O Strong Altered Expression [765]
RGS14 OTYN79AG Strong Genetic Variation [236]
RIC3 OTDCM6GS Strong Biomarker [387]
RIOK1 OT1OS3H3 Strong Biomarker [748]
RMDN1 OTE1NB6U Strong Biomarker [766]
RMDN2 OTK5WSFI Strong Biomarker [766]
RMDN3 OTKO7AUM Strong Biomarker [766]
RMI2 OTA0HP4S Strong Genetic Variation [236]
RNASE2 OT8Z4FNE Strong Biomarker [641]
RNF5 OTDQGI37 Strong Genetic Variation [260]
RPA1 OT76POLP Strong Biomarker [767]
RPAP2 OTW9XR12 Strong Genetic Variation [328]
RPS6 OTT4D1LN Strong Altered Expression [768]
RRN3 OTKGOZ49 Strong Biomarker [561]
SACS OTZGXQ8A Strong Biomarker [769]
SAE1 OT18HFX5 Strong Genetic Variation [328]
SALL1 OTYYZGLH Strong Biomarker [770]
SART3 OTC1AM7S Strong Biomarker [359]
SBNO2 OT1C6J3K Strong Genetic Variation [212]
SDF4 OTQ7WFYW Strong Altered Expression [616]
SEC14L2 OTJST64D Strong Biomarker [532]
SEMA4A OT8901H3 Strong Biomarker [771]
SEMA7A OT0ZJK64 Strong Biomarker [772]
SERPINA3 OT9BP2S0 Strong Altered Expression [244]
SERPINB2 OT72QLZB Strong Biomarker [737]
SGSM3 OTIB1P8A Strong Biomarker [766]
SH3BP2 OT90JNBS Strong Genetic Variation [236]
SH3YL1 OTVXOONW Strong Posttranslational Modification [773]
SIGLEC1 OTNWSQA9 Strong Altered Expression [774]
SIRPG OTE2P8G0 Strong Genetic Variation [212]
SKAP2 OTSF44KP Strong Genetic Variation [236]
SLC16A4 OT1YXBKC Strong Altered Expression [405]
SLC2A4RG OTW3LX8D Strong Altered Expression [560]
SNCB OTELSEK6 Strong Biomarker [775]
SND1 OTT734JN Strong Biomarker [359]
SORCS3 OT4VOMBC Strong Biomarker [776]
SOX10 OTF25ULQ Strong Altered Expression [777]
SOX8 OTEJXYZM Strong Genetic Variation [778]
SP3 OTYDQZ1T Strong Altered Expression [779]
SPATA2 OTOA45GL Strong Genetic Variation [212]
SPEF2 OTO04K1T Strong Genetic Variation [780]
SPG11 OTZ7LJX4 Strong Genetic Variation [781]
SPRED2 OTUX685J Strong Genetic Variation [212]
SRSF1 OTF61HOV Strong Biomarker [585]
STAT2 OTO9G2RZ Strong Genetic Variation [212]
STING1 OTDAP4G0 Strong Biomarker [782]
STK19 OTYM6437 Strong Genetic Variation [260]
STX1A OTSBUZB4 Strong Biomarker [411]
SUGP1 OT7W0EB8 Strong Biomarker [783]
SUMF1 OTALXO2A Strong Genetic Variation [784]
SYBU OT3FQV7N Strong Biomarker [766]
SYN1 OTMNPWC1 Strong Biomarker [785]
SYN3 OTSGYNA5 Strong Biomarker [786]
SYT1 OTVTPOI6 Strong Altered Expression [444]
SYT11 OTLRTZEI Strong Genetic Variation [411]
SYT14 OTE1V1OW Strong Genetic Variation [695]
TAGAP OTHJNNO2 Strong Genetic Variation [787]
TALDO1 OTDKV2S2 Strong Biomarker [788]
TCF19 OT7NKLF9 Strong Genetic Variation [260]
TEF OTY3LAD9 Strong Genetic Variation [236]
TET2 OTKKT03T Strong Altered Expression [789]
THEMIS OTXODBXJ Strong Biomarker [790]
TIMMDC1 OTIK4I5R Strong Genetic Variation [236]
TIMP1 OTOXC51H Strong Altered Expression [583]
TMED5 OT70W1J8 Strong Biomarker [303]
TMEM119 OT0HFEIC Strong Biomarker [472]
TNIP1 OTRAOTEW Strong Genetic Variation [212]
TNXB OTVBWAV5 Strong Genetic Variation [260]
TOB1 OTNW949D Strong Biomarker [791]
TOP3A OT3CKUI9 Strong Genetic Variation [348]
TOR2A OT1EGCDU Strong Altered Expression [792]
TPRG1L OTU7GPKK Strong Altered Expression [793]
TRAF1 OTTLM5RU Strong Genetic Variation [212]
TRAF2 OT1MEZZN Strong Altered Expression [794]
TRAF3 OT5TQBGV Strong Genetic Variation [746]
TRAPPC9 OTF0CVMC Strong Biomarker [387]
TSBP1 OT5GE8IO Strong Genetic Variation [795]
TSFM OTP6OKPJ Strong Biomarker [654]
TSPAN31 OT8WQ83R Strong Genetic Variation [240]
TSPAN32 OTSXW7EW Strong Altered Expression [796]
TSPAN4 OTKFK57F Strong Biomarker [797]
TTC34 OT6UGMDV Strong Genetic Variation [240]
ADNP OTEGICWR Definitive Altered Expression [798]
APOC1 OTA58CED Definitive Biomarker [799]
APOD OTT77XW8 Definitive Biomarker [800]
ARHGEF2 OTBQTFRT Definitive Altered Expression [560]
ASAP2 OTGEXULW Definitive Genetic Variation [494]
BSN OTZ72VIB Definitive Genetic Variation [356]
CARTPT OTTE4V9S Definitive Altered Expression [801]
CAST OTBXZZGF Definitive Biomarker [802]
CCL13 OTNX0JD0 Definitive Genetic Variation [803]
CCL19 OTQ2UJMH Definitive Biomarker [804]
CDK2AP1 OTNFOHDJ Definitive Biomarker [716]
CDKN2D OT2TTZPZ Definitive Biomarker [805]
CKLF OTHLPHA0 Definitive Biomarker [806]
CP OTM8JE4Y Definitive Biomarker [807]
CRTAP OT53H5U6 Definitive Biomarker [808]
CRYGC OTYSTQWI Definitive Biomarker [809]
CSMD1 OTIVDSC4 Definitive Genetic Variation [494]
CSN3 OTR61MI8 Definitive Altered Expression [810]
CTR9 OTP151PZ Definitive Biomarker [543]
CUX1 OTU1LCNJ Definitive Biomarker [359]
CYTB OTAHB98A Definitive Biomarker [811]
CYTIP OTRJ3ZC5 Definitive Biomarker [808]
DARS2 OTVPFTBG Definitive Genetic Variation [812]
DBP OTE0W7LN Definitive Genetic Variation [813]
DCTN1 OT5B51FJ Definitive Biomarker [543]
DNTT OTFSEF12 Definitive Genetic Variation [814]
ELP1 OTYEWBF7 Definitive Biomarker [543]
GK5 OT65U8L1 Definitive Biomarker [815]
GZMK OT6O7PCT Definitive Biomarker [816]
H6PD OTO7TNDD Definitive Biomarker [817]
HLA-DOA OTZE5Q7R Definitive Altered Expression [326]
HSPA1A OTKGIE76 Definitive Genetic Variation [684]
HSPA4 OT5HR0AR Definitive Genetic Variation [818]
IL17RC OTEFOBSS Definitive Altered Expression [457]
IL18BP OTW0LRYZ Definitive Altered Expression [819]
INTS4 OT5JQ913 Definitive Genetic Variation [820]
IRF5 OT8SIIAP Definitive Biomarker [821]
KAT5 OTL7257A Definitive Biomarker [510]
KIR2DL5A OT09FZE1 Definitive Biomarker [465]
KIR2DL5B OTSV0JL9 Definitive Biomarker [465]
KIR3DS1 OTJWIO4T Definitive Biomarker [465]
KLRC2 OTT4N86S Definitive Biomarker [822]
LBR OT1HG3HG Definitive Biomarker [823]
LRRC34 OTSPZLKF Definitive Genetic Variation [391]
MICB OTS2DVDW Definitive Biomarker [654]
MMP24 OTF8T3JM Definitive Biomarker [824]
MMP28 OTHQZXM1 Definitive Biomarker [824]
MOGAT1 OTZP43K4 Definitive Genetic Variation [825]
MSC OTBRPZL5 Definitive Biomarker [826]
MYT1 OTC3660I Definitive Altered Expression [827]
NAIP OTLA925F Definitive Genetic Variation [446]
NCOA5 OTOGWTWB Definitive Genetic Variation [391]
ND5 OT45LW1K Definitive Genetic Variation [828]
NRM OTK7F9XZ Definitive Genetic Variation [829]
OAS1 OT8ZLOCY Definitive Genetic Variation [830]
OLIG1 OTIMFI31 Definitive Altered Expression [831]
PDZRN4 OTHPD5LB Definitive Genetic Variation [494]
PIK3R4 OTRL8QP8 Definitive Biomarker [543]
PVALB OTZW1WVQ Definitive Biomarker [832]
RAB3GAP2 OTQTE0GI Definitive Biomarker [543]
RAP1A OT5RH6TI Definitive Biomarker [833]
RGMB OT2DROYU Definitive Biomarker [834]
RPL5 OTM8EBRI Definitive Genetic Variation [835]
RREB1 OT62460U Definitive Genetic Variation [391]
SH2D2A OTQSKW7U Definitive Genetic Variation [836]
SH3GL2 OTOE443G Definitive Genetic Variation [494]
SIL1 OTDI85I5 Definitive Genetic Variation [837]
SORL1 OTQ8FFNS Definitive Biomarker [838]
TAC3 OTOJGM38 Definitive Biomarker [839]
TAC4 OTYWPPM3 Definitive Genetic Variation [839]
TBATA OTGDMAAL Definitive Biomarker [840]
TBC1D2 OTSGHPD0 Definitive Genetic Variation [494]
TMEM74B OTM7QFEC Definitive Genetic Variation [494]
TNFRSF10C OTVHOL9B Definitive Biomarker [841]
TNFRSF10D OTOSRDJT Definitive Biomarker [841]
TNFRSF19 OTTVT4MB Definitive Altered Expression [842]
TNPO2 OTGHFQAV Definitive Genetic Variation [391]
TRIB2 OTHSX3MX Definitive Genetic Variation [494]
------------------------------------------------------------------------------------
⏷ Show the Full List of 581 DOT(s)

References

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3 Alfuzosin FDA Label
4 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
5 Clinical pipeline report, company report or official report of Revo biologics.
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7 Betamethasone FDA Label
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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10 Cyclophosphamide FDA Label
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12 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
13 Dexamethasone FDA Label
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15 Everolimus FDA Label
16 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
17 Fludarabine FDA Label
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19 Hydrocortisone FDA Label
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24 Methylprednisolone FDA Label
25 Methyltestosterone FDA Label
26 FDA Approved Drug Products from FDA Official Website.
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32 Prednisone FDA Label
33 ClinicalTrials.gov (NCT01359943) Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate
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35 Sirolimus FDA Label
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38 Testosterone FDA Label
39 Triamcinolone FDA Label
40 FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761238.
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54 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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57 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
58 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025673)
59 Clinical pipeline report, company report or official report of Allozyne Inc.
60 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800038259)
61 ClinicalTrials.gov (NCT00382629) BHT-3009 Immunotherapy in Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
62 Randomized phase I trials of the safety/tolerability of anti-LINGO-1 monoclonal antibody BIIB033. Neurol Neuroimmunol Neuroinflamm. 2014 Aug 21;1(2):e18.
63 Emerging drugs for rheumatoid arthritis. Expert Opin Emerg Drugs. 2008 Mar;13(1):175-96.
64 ClinicalTrials.gov (NCT03737812) A Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis. U.S. National Institutes of Health.
65 ClinicalTrials.gov (NCT00001929) Treatment of Parkinson's Disease With Eliprodil. U.S. National Institutes of Health.
66 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018762)
67 A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
68 ClinicalTrials.gov (NCT04879628) A Phase 2, Double-blind, Randomized, Placebo-controlled Study Assessing Efficacy and Safety of SAR441344, a CD40L-antagonist Monoclonal Antibody, in Participants With Relapsing Multiple Sclerosis. U.S.National Institutes of Health.
69 Clinical pipeline report, company report or official report of Gemac Bio.
70 ClinicalTrials.gov (NCT01639300) Safety Study of GNbAC1 in Multiple Sclerosis Patients. U.S. National Institutes of Health.
71 Emerging drugs for spinal cord injury. Expert Opin Emerg Drugs. 2008 Mar;13(1):63-80.
72 ClinicalTrials.gov (NCT01684761) Study of Tcelna (Imilecleucel-T) in Secondary Progressive Multiple Sclerosis. U.S. National Institutes of Health.
73 ClinicalTrials.gov (NCT00239655) A Study to Assess the Effects of MK0812 on Disease Activity in Patients With Relapsing-Remitting Multiple Sclerosis as Measured by Magnetic Resonance Imaging (MRI). U.S. National Institutes of Health.
74 Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
75 ClinicalTrials.gov (NCT01890655) Extension Study of MT-1303. U.S. National Institutes of Health.
76 ClinicalTrials.gov (NCT00001781) Safety, Tolerability, and Effectiveness of CGP77116 in Patients With Multiple Sclerosis (MS). U.S. National Institutes of Health.
77 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021098)
78 ClinicalTrials.gov (NCT01963611) Efficacy, Safety, and Tolerability of Plovamer Acetate (Pathway 1). U.S. National Institutes of Health.
79 ClinicalTrials.gov (NCT01714089) Proof of Concept Study Evaluating RNS60 in the Treatment of Relapsing Remitting Multiple Sclerosis. U.S. National Institutes of Health.
80 ClinicalTrials.gov (NCT01008852) Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis. U.S. National Institutes of Health.
81 ClinicalTrials.gov (NCT00245622) Autologous T Cell Vaccine (TCV) for Multiple Sclerosis. U.S. National Institutes of Health.
82 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013427)
83 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022066)
84 ClinicalTrials.gov (NCT02222948) Efficacy and Safety of Vatelizumab in Patients With Relapsing-Remitting Multiple Sclerosis. U.S. National Institutes of Health.
85 ClinicalTrials.gov (NCT01259726) Safety and Efficacy Study of VP20621 for Prevention of Recurrent Clostridium Difficile Infection. U.S. National Institutes of Health.
86 ClinicalTrials.gov (NCT01764737) Evaluation of Safety, Tolerability, and PK of VX15/2503 In Patients With MS. U.S. National Institutes of Health.
87 ClinicalTrials.gov (NCT02173301) A Study to Assess the Efficacy and Safety of XP23829 in Subjects With Moderate-to-Severe Chronic Plaque-Type Psoriasis. U.S. National Institutes of Health.
88 ClinicalTrials.gov (NCT01023256) Safety and Preliminary Efficacy of MOR103 in Patients With Active Rheumatoid Arthritis. U.S. National Institutes of Health.
89 ClinicalTrials.gov (NCT01154387) Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection. U.S. National Institutes of Health.
90 Clinical pipeline report, company report or official report of Merck Serono.
91 ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819.
92 ClinicalTrials.gov (NCT02071121) Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volunteers Including Absolute Bioavailability and Food Effect. U.S. National Institutes of Health.
93 ClinicalTrials.gov (NCT03943056) A Phase 1, Randomized, Blinded, Placebo-Controlled, Single- and Multiple-Ascending Dose, Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of BIIB091, a Bruton's Tyrosine Kinase (BTK) Inhibitor, in Healthy Adult Participants. U.S.National Institutes of Health.
94 ClinicalTrials.gov (NCT04593121) A Phase 1, Randomized, Blinded, Placebo-Controlled, Single- and Multiple-Ascending-Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB107 in Healthy Adult Participants. U.S.National Institutes of Health.
95 ClinicalTrials.gov (NCT00616733) 12-week Safety Evaluation of Oral CS-0777 in Multiple Sclerosis Patients. U.S. National Institutes of Health.
96 ClinicalTrials.gov (NCT01738347) Assess Safety, Bio-distribution, Dosimetry, and Optimize Imaging Protocol of GEH120714 (18F) Injection, in Healthy Volunteers and Participants With Relapsing and Remitting Multiple Sclerosis (rrMS). U.S. National Institutes of Health.
97 ClinicalTrials.gov (NCT01808482) A First Time in Human Study Exploring Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2618960 in Healthy Volunteers and Patients With Relapsing Remitting Multiple Sclerosis (RRMS). U.S. National Institutes of Health.
98 ClinicalTrials.gov (NCT05131971) A Randomized, Double-Blind, Placebo Controlled, Single Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK3888130B in Healthy Participants Aged 18-55 Inclusive. U.S.National Institutes of Health.
99 ClinicalTrials.gov (NCT02282826) A First-in-human, Single Ascending Dose Study of GZ402668 in Patients With Progressive Multiple Sclerosis. U.S. National Institutes of Health.
100 ClinicalTrials.gov (NCT01296386) An Open-label Study Assessing Safety, Immunogenicity and Dose Response of IC84. U.S. National Institutes of Health.
101 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028859)
102 Antigen-Specific Blocking of CD4-Specific Immunological Synapse Formation Using BPI and Current Therapies for Autoimmune Diseases. Med Res Rev. 2012 July; 32(4): 727-764.
103 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032732)
104 Clinical pipeline report, company report or official report of Roche
105 ClinicalTrials.gov (NCT00411723) Safety Study of RTL1000 (Recombinant T Cell Receptor Ligand) in Subjects With Multiple Sclerosis. U.S. National Institutes of Health.
106 ClinicalTrials.gov (NCT00411723) Safety Study of RTL1000 (Recombinant T Cell Receptor Ligand) in Subjects With Multiple Sclerosis. U.S. National Institutes of Health.
107 Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2531-6.
108 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
109 Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83.
110 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016720)
111 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009065)
112 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009031)
113 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015672)
114 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008511)
115 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028330)
116 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007802)
117 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018778)
118 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7728).
119 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035649)
120 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024340)
121 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020823)
122 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012563)
123 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009742)
124 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013050)
125 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
126 The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice. Eur J Pharmacol. 2017 May 5;802:76-84.
127 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032947)
128 Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov. 2019 Apr;18(4):295-317.
129 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006361)
130 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021743)
131 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000987)
132 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030149)
133 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007767)
134 Estrogen: estrone (E1), estradiol (E2), estriol (E3) and estetrol (E4). Nihon Rinsho. 2010 Jul;68 Suppl 7:448-61.
135 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 275).
136 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1870).
137 Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.J Rheumatol. 2011 Sep;38(9):1866-70. doi: 10.3899/jrheum.110199. Epub 2011 Jul 15.
138 An immunogenetic heterogeneity in multiple sclerosis.J Neurol Neurosurg Psychiatry. 1992 Oct;55(10):887-90. doi: 10.1136/jnnp.55.10.887.
139 The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis.J Immunol. 1998 Apr 1;160(7):3543-54.
140 Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression.J Immunol. 2000 Dec 1;165(11):6576-82. doi: 10.4049/jimmunol.165.11.6576.
141 Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility.J Neuroimmunol. 2001 May 1;116(1):116-24. doi: 10.1016/s0165-5728(01)00283-1.
142 Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes.Neurochem Res. 2015 Nov;40(11):2333-47. doi: 10.1007/s11064-015-1723-x. Epub 2015 Sep 23.
143 Both the HLA-CPB1 and -DRB1 alleles correlate with risk for multiple sclerosis in Japanese: clinical phenotypes and gender as important factors.Tissue Antigens. 2000 Mar;55(3):199-205. doi: 10.1034/j.1399-0039.2000.550302.x.
144 Protective effects of CX3CR1 on autoimmune inflammation in a chronic EAE model for MS through modulation of antigen-presenting cell-related molecular MHC-II and its regulators.Neurol Sci. 2019 Apr;40(4):779-791. doi: 10.1007/s10072-019-3721-2. Epub 2019 Jan 23.
145 Pathological roles of the homeostatic chemokine CXCL12.Cytokine Growth Factor Rev. 2018 Dec;44:51-68. doi: 10.1016/j.cytogfr.2018.10.004. Epub 2018 Oct 23.
146 Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study.J Neuroinflammation. 2019 Mar 11;16(1):59. doi: 10.1186/s12974-019-1440-5.
147 Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown.Int J Mol Sci. 2019 Jan 30;20(3):602. doi: 10.3390/ijms20030602.
148 MAIT cell subtypes in multiple sclerosis.J Neuroimmunol. 2020 Feb 15;339:577117. doi: 10.1016/j.jneuroim.2019.577117. Epub 2019 Nov 20.
149 The Level of Testosterone, Vitamin D, and Irregular Menstruation More Important than Omega-3 in Non-Symptomatic Women Will Define the Fate of Multiple Scleroses in Future.Mol Neurobiol. 2018 Jan;55(1):462-469. doi: 10.1007/s12035-016-0325-1. Epub 2016 Dec 13.
150 Multiple sclerosis treatment effects on plasma cytokine receptor levels.Clin Immunol. 2018 Feb;187:15-25. doi: 10.1016/j.clim.2017.08.023. Epub 2017 Sep 21.
151 Association between the gamma-aminobutyric acid A3 receptor gene and multiple sclerosis.Arch Neurol. 1998 Apr;55(4):513-6. doi: 10.1001/archneur.55.4.513.
152 GPR17 receptor modulators and their therapeutic implications: review of recent patents.Expert Opin Ther Pat. 2019 Feb;29(2):85-95. doi: 10.1080/13543776.2019.1568990. Epub 2019 Jan 24.
153 Localization of near-infrared labeled antibodies to the central nervous system in experimental autoimmune encephalomyelitis.PLoS One. 2019 Feb 15;14(2):e0212357. doi: 10.1371/journal.pone.0212357. eCollection 2019.
154 Interaction of disease-related antigen-reactive T-cell lines from multiple sclerosis patients with type IV collagen: role of integrin VLA-1 and effects of irradiation.J Clin Immunol. 2002 May;22(3):153-63. doi: 10.1023/a:1015472013500.
155 Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides.Sci Rep. 2019 Sep 10;9(1):12994. doi: 10.1038/s41598-019-49385-6.
156 V delta 1 gene usage, interleukin-2 receptors and adhesion molecules on gamma delta+ T cells in inflammatory diseases of the nervous system.J Neuroimmunol. 1994 Jan;49(1-2):59-66. doi: 10.1016/0165-5728(94)90181-3.
157 B cells from patients with multiple sclerosis have a pathogenic phenotype and increased LT and TGF1 response.J Neuroimmunol. 2018 Nov 15;324:157-164. doi: 10.1016/j.jneuroim.2018.09.001. Epub 2018 Sep 7.
158 A novel microtubule-associated protein-2 expressed in oligodendrocytes in multiple sclerosis lesions.J Neurochem. 1999 Dec;73(6):2531-7. doi: 10.1046/j.1471-4159.1999.0732531.x.
159 NCAM1 is the Target of miRNA-572: Validation in the Human Oligodendroglial Cell Line.Cell Mol Neurobiol. 2018 Mar;38(2):431-440. doi: 10.1007/s10571-017-0486-0. Epub 2017 Mar 22.
160 Analysis of NOD-like receptor NLRP1 in multiple sclerosis families.Immunogenetics. 2018 Mar;70(3):205-207. doi: 10.1007/s00251-017-1034-2. Epub 2017 Oct 7.
161 Association between the phenylethanolamine N-methyltransferase gene and multiple sclerosis.J Neuroimmunol. 2002 Mar;124(1-2):101-5. doi: 10.1016/s0165-5728(02)00009-7.
162 Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection.J Neurosci Res. 2018 Mar;96(3):427-435. doi: 10.1002/jnr.24141. Epub 2017 Sep 6.
163 Prolactin and prolactin receptor gene polymorphisms in multiple sclerosis and systemic lupus erythematosus.Hum Immunol. 2003 Feb;64(2):274-84. doi: 10.1016/s0198-8859(02)00804-2.
164 miR-140-5p regulates T cell differentiation and attenuates experimental autoimmune encephalomyelitis by affecting CD4(+)T cell metabolism and DNA methylation.Int Immunopharmacol. 2019 Oct;75:105778. doi: 10.1016/j.intimp.2019.105778. Epub 2019 Sep 5.
165 Tissue Transglutaminase Appears in Monocytes and Macrophages but Not in Lymphocytes in White Matter Multiple Sclerosis Lesions.J Neuropathol Exp Neurol. 2019 Jun 1;78(6):492-500. doi: 10.1093/jnen/nlz030.
166 Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis.J Neuroimmunol. 2003 May;138(1-2):115-22. doi: 10.1016/s0165-5728(03)00090-0.
167 The T-cell receptor beta locus and susceptibility to multiple sclerosis.Neurology. 1995 Oct;45(10):1859-63. doi: 10.1212/wnl.45.10.1859.
168 Therapeutic potential of tyrosine kinase 2 in autoimmunity.Expert Opin Ther Targets. 2014 May;18(5):571-80. doi: 10.1517/14728222.2014.892925. Epub 2014 Mar 21.
169 Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter.Mult Scler. 2006 Aug;12(4):386-96. doi: 10.1191/135248506ms1300oa.
170 IFNG polymorphisms are associated with gender differences in susceptibility to multiple sclerosis.Genes Immun. 2005 Mar;6(2):153-61. doi: 10.1038/sj.gene.6364164.
171 Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis.J Neuropathol Exp Neurol. 2006 Sep;65(9):855-65. doi: 10.1097/01.jnen.0000235119.52311.16.
172 Interferon-gamma mRNA attenuates its own translation by activating PKR: a molecular basis for the therapeutic effect of interferon-beta in multiple sclerosis.Cell Res. 2006 Feb;16(2):148-53. doi: 10.1038/sj.cr.7310020.
173 Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions.J Neuroimmunol. 2005 Jan;158(1-2):182-90. doi: 10.1016/j.jneuroim.2004.08.012.
174 Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans.Genes Immun. 2006 Jun;7(4):310-5. doi: 10.1038/sj.gene.6364299. Epub 2006 Apr 20.
175 Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.J Neuroimmunol. 2005 Apr;161(1-2):195-8. doi: 10.1016/j.jneuroim.2004.12.014.
176 Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis.Neurobiol Dis. 2005 Apr;18(3):537-50. doi: 10.1016/j.nbd.2004.10.007.
177 Increased expression and function of glutamate transporters in multiple sclerosis.Neurobiol Dis. 2006 Jan;21(1):154-64. doi: 10.1016/j.nbd.2005.06.017. Epub 2005 Aug 2.
178 Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.Sci Transl Med. 2019 Nov 13;11(518):eaaw0475. doi: 10.1126/scitranslmed.aaw0475.
179 CD47 expression regulated by the miR-133a tumor suppressor is a novel prognostic marker in esophageal squamous cell carcinoma.Oncol Rep. 2012 Aug;28(2):465-72. doi: 10.3892/or.2012.1831. Epub 2012 May 24.
180 The Link Between CD6 and Autoimmunity: Genetic and Cellular Associations.Curr Drug Targets. 2016;17(6):651-65. doi: 10.2174/1389450117666160201105934.
181 How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression.J Vis Exp. 2017 Jan 23;(119):55100. doi: 10.3791/55100.
182 Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry.PLoS Genet. 2019 Jan 17;15(1):e1007808. doi: 10.1371/journal.pgen.1007808. eCollection 2019 Jan.
183 Immune response genes receptors expression and polymorphisms in relation to multiple sclerosis susceptibility and response to INF- therapy.IUBMB Life. 2016 Sep;68(9):727-34. doi: 10.1002/iub.1530. Epub 2016 Jun 27.
184 LINGO-1-Fc-Transduced Neural Stem Cells Are Effective Therapy for Chronic Stage Experimental Autoimmune Encephalomyelitis.Mol Neurobiol. 2017 Aug;54(6):4365-4378. doi: 10.1007/s12035-016-9994-z. Epub 2016 Jun 25.
185 Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.Cancer Biomark. 2018;21(4):883-891. doi: 10.3233/CBM-170942.
186 NCF1 gene and pseudogene pattern: association with parasitic infection and autoimmunity.Malar J. 2008 Dec 11;7:251. doi: 10.1186/1475-2875-7-251.
187 Genetic variants regulate NR1H3 expression and contribute to multiple sclerosis risk.J Neurol Sci. 2018 Jul 15;390:162-165. doi: 10.1016/j.jns.2018.04.037. Epub 2018 Apr 22.
188 Targeting P2X4 and P2X7 receptors in multiple sclerosis.Curr Opin Pharmacol. 2019 Aug;47:119-125. doi: 10.1016/j.coph.2019.03.010. Epub 2019 Apr 20.
189 Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis.Bioorg Med Chem. 2017 May 1;25(9):2643-2656. doi: 10.1016/j.bmc.2017.03.006. Epub 2017 Mar 6.
190 Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort.Int J Immunogenet. 2015 Apr;42(2):106-10. doi: 10.1111/iji.12183. Epub 2015 Feb 12.
191 Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis.Eur J Neurol. 2020 Feb;27(2):221-228. doi: 10.1111/ene.14105. Epub 2019 Nov 6.
192 Serum levels of LIGHT in MS.Mult Scler. 2013 Jun;19(7):871-6. doi: 10.1177/1352458512463766. Epub 2012 Oct 4.
193 UCP2 up-regulation within the course of autoimmune encephalomyelitis correlates with T-lymphocyte activation.Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):1002-1012. doi: 10.1016/j.bbadis.2017.01.019. Epub 2017 Jan 25.
194 Hypoxia mimetic activity of VCE-004.8, a cannabidiol quinone derivative: implications for multiple sclerosis therapy.J Neuroinflammation. 2018 Mar 1;15(1):64. doi: 10.1186/s12974-018-1103-y.
195 Re-examining the potential of targeting ABHD6 in multiple sclerosis: Efficacy of systemic and peripherally restricted inhibitors in experimental autoimmune encephalomyelitis.Neuropharmacology. 2018 Oct;141:181-191. doi: 10.1016/j.neuropharm.2018.08.038. Epub 2018 Aug 30.
196 DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.Brain. 2014 May;137(Pt 5):1454-69. doi: 10.1093/brain/awu045. Epub 2014 Mar 12.
197 Mitochondrial complex enzyme activities and cytochrome C expression changes in multiple sclerosis.Mol Neurobiol. 2014 Feb;49(1):1-9. doi: 10.1007/s12035-013-8481-z. Epub 2013 Jun 13.
198 Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.J Neuroimmunol. 2009 May 29;210(1-2):108-12. doi: 10.1016/j.jneuroim.2009.02.008. Epub 2009 Mar 25.
199 PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis.J Mol Neurosci. 2019 Jul;68(3):439-451. doi: 10.1007/s12031-018-1137-8. Epub 2018 Jul 30.
200 Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions.Front Immunol. 2019 Apr 24;10:855. doi: 10.3389/fimmu.2019.00855. eCollection 2019.
201 Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease.J Neuroimmune Pharmacol. 2020 Jun;15(2):249-263. doi: 10.1007/s11481-019-09894-7. Epub 2019 Dec 11.
202 Potential role of calcifying nanoparticles in the etiology of multiple sclerosis.Med Hypotheses. 2019 Jul;128:25-27. doi: 10.1016/j.mehy.2019.05.005. Epub 2019 May 11.
203 Isotype-Switched Autoantibodies Are Necessary To Facilitate Central Nervous System Autoimmune Disease in Aicda(-/-) and Ung(-/-) Mice.J Immunol. 2018 Aug 15;201(4):1119-1130. doi: 10.4049/jimmunol.1700729. Epub 2018 Jul 6.
204 Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE.Eur J Immunol. 2016 Mar;46(3):570-81. doi: 10.1002/eji.201545782. Epub 2016 Jan 22.
205 Angiopoietin-like proteins in multiple sclerosis.J Neuroimmunol. 2019 May 15;330:31-34. doi: 10.1016/j.jneuroim.2019.02.006. Epub 2019 Feb 15.
206 Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells.PLoS One. 2018 Feb 2;13(2):e0192109. doi: 10.1371/journal.pone.0192109. eCollection 2018.
207 Are Plasma Levels of Vascular Adhesion Protein-1 Associated Both with Cerebral Microbleeds in Multiple Sclerosis and Intracerebral Haemorrhages in Stroke?.Thromb Haemost. 2019 Jan;119(1):175-178. doi: 10.1055/s-0038-1676346. Epub 2018 Dec 31.
208 Mir-223 regulates the number and function of myeloid-derived suppressor cells in multiple sclerosis and experimental autoimmune encephalomyelitis.Acta Neuropathol. 2017 Jan;133(1):61-77. doi: 10.1007/s00401-016-1621-6. Epub 2016 Oct 4.
209 Deletion of Arginase 2 Ameliorates Retinal Neurodegeneration in a Mouse Model of Multiple Sclerosis.Mol Neurobiol. 2019 Dec;56(12):8589-8602. doi: 10.1007/s12035-019-01691-w. Epub 2019 Jul 6.
210 Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride.Brain. 2013 Jan;136(Pt 1):106-15. doi: 10.1093/brain/aws325.
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215 Expression of Bone Morphogenetic Proteins in Multiple Sclerosis Lesions.Am J Pathol. 2019 Mar;189(3):665-676. doi: 10.1016/j.ajpath.2018.11.007. Epub 2018 Dec 13.
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220 Inflammasome Proteins As Biomarkers of Multiple Sclerosis.Front Neurol. 2018 Mar 19;9:135. doi: 10.3389/fneur.2018.00135. eCollection 2018.
221 Central Nervous System and Peripheral Expression of CCL19, CCL21 and Their Receptor CCR7 in Experimental Model of Multiple Sclerosis.Arch Immunol Ther Exp (Warsz). 2015 Oct;63(5):367-76. doi: 10.1007/s00005-015-0339-9. Epub 2015 May 10.
222 Gender-specific influence of the chromosome 16 chemokine gene cluster on the susceptibility to Multiple Sclerosis.J Neurol Sci. 2008 Apr 15;267(1-2):86-90. doi: 10.1016/j.jns.2007.10.001. Epub 2007 Oct 29.
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225 Gut microbiota-dependent CCR9+CD4+ T cells are altered in secondary progressive multiple sclerosis.Brain. 2019 Apr 1;142(4):916-931. doi: 10.1093/brain/awz012.
226 Monocyte and Lymphocyte Activation and Regulation in Multiple Sclerosis Patients. Therapy Effects.J Neuroimmune Pharmacol. 2019 Sep;14(3):413-422. doi: 10.1007/s11481-018-09832-z. Epub 2019 Jan 16.
227 Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immune-tolerance promoting CD8 T-cell population. Implications for secondary autoimmunity of alemtuzumab in multiple sclerosis.Immunology. 2017 Apr;150(4):444-455. doi: 10.1111/imm.12696. Epub 2017 Jan 3.
228 CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):175-83. doi: 10.1177/039463201102400120.
229 Preparation, characterization, and transfection efficiency of low molecular weight polyethylenimine-based nanoparticles for delivery of the plasmid encoding CD200 gene.Int J Nanomedicine. 2017 Aug 3;12:5557-5569. doi: 10.2147/IJN.S140734. eCollection 2017.
230 Cerebrospinal Fluid Level of Soluble CD27 Is Associated with Disease Severity in Neuromyelitis Optica Spectrum Disorder.Neuroimmunomodulation. 2018;25(4):185-192. doi: 10.1159/000489561. Epub 2018 Nov 13.
231 B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets.PLoS One. 2015 Jun 11;10(6):e0130126. doi: 10.1371/journal.pone.0130126. eCollection 2015.
232 Altered Expression of miR-326 in T Cell-derived Exosomes of Patients with Relapsing-remitting Multiple Sclerosis.Iran J Allergy Asthma Immunol. 2019 Feb;18(1):108-113.
233 Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.Am J Pathol. 2008 Jan;172(1):146-55. doi: 10.2353/ajpath.2008.070690. Epub 2007 Dec 21.
234 Severe B cell-mediated disease activation despite two cycles of alemtuzumab in a patient with multiple sclerosis.Mult Scler. 2019 Dec;25(14):1942-1945. doi: 10.1177/1352458518810261. Epub 2018 Nov 7.
235 Analysis of chosen SNVs in GPC5, CD58 and IRF8 genes in multiple sclerosis patients.Adv Med Sci. 2019 Sep;64(2):230-234. doi: 10.1016/j.advms.2018.12.004. Epub 2019 Feb 26.
236 Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.Nat Genet. 2013 Nov;45(11):1353-60. doi: 10.1038/ng.2770. Epub 2013 Sep 29.
237 Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset.J Neuroimmunol. 2015 Nov 15;288:79-86. doi: 10.1016/j.jneuroim.2015.09.004. Epub 2015 Sep 18.
238 The levels of soluble forms of CD21 and CD83 in multiple sclerosis.J Neuroimmunol. 2018 Jul 15;320:11-14. doi: 10.1016/j.jneuroim.2018.04.005. Epub 2018 Apr 13.
239 Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells.Brain. 2018 Mar 1;141(3):786-796. doi: 10.1093/brain/awx372.
240 Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.Nature. 2011 Aug 10;476(7359):214-9. doi: 10.1038/nature10251.
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242 Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway.PLoS One. 2013 Jun 19;8(6):e65936. doi: 10.1371/journal.pone.0065936. Print 2013.
243 Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.Sci Rep. 2017 Jun 2;7(1):2707. doi: 10.1038/s41598-017-03027-x.
244 Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity.Mult Scler Relat Disord. 2019 Feb;28:34-43. doi: 10.1016/j.msard.2018.11.032. Epub 2018 Dec 5.
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247 Cannabinoid receptors as therapeutic targets for autoimmune diseases: where do we stand?.Drug Discov Today. 2019 Sep;24(9):1845-1853. doi: 10.1016/j.drudis.2019.05.023. Epub 2019 May 31.
248 Cannabinoid CB2 Receptor Functional Variation (Q63R) Is Associated with Multiple Sclerosis in Iranian Subjects.J Mol Neurosci. 2020 Jan;70(1):26-31. doi: 10.1007/s12031-019-01395-9. Epub 2019 Aug 13.
249 Anti-neurofascin autoantibody and demyelination.Neurochem Int. 2019 Nov;130:104360. doi: 10.1016/j.neuint.2018.12.011. Epub 2018 Dec 22.
250 Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.Clin Epigenetics. 2019 May 30;11(1):86. doi: 10.1186/s13148-019-0678-1.
251 The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.Nat Commun. 2015 Jun 2;6:7216. doi: 10.1038/ncomms8216.
252 Small Heat Shock Proteins, Amyloid Fibrils, and Nicotine Stimulate a Common Immune Suppressive Pathway with Implications for Future Therapies.Cold Spring Harb Perspect Med. 2019 Jul 1;9(7):a034223. doi: 10.1101/cshperspect.a034223.
253 Elevated expression of granulocyte-macrophage colony-stimulating factor receptor in multiple sclerosis lesions.J Neuroimmunol. 2018 Apr 15;317:45-54. doi: 10.1016/j.jneuroim.2017.12.017. Epub 2017 Dec 22.
254 Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis.Pain. 2019 Sep;160(9):2050-2062. doi: 10.1097/j.pain.0000000000001596.
255 Cathepsin H deficiency in mice induces excess Th1 cell activation and early-onset of EAE though impairment of toll-like receptor 3 cascade.Inflamm Res. 2018 May;67(5):371-374. doi: 10.1007/s00011-018-1136-9. Epub 2018 Feb 22.
256 CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration.Adv Clin Exp Med. 2018 Jun;27(6):849-856. doi: 10.17219/acem/68846.
257 Cytokine-chemokine and cognitive profile of multiple sclerosis patients with predominant optic nerve and spinal cord involvement.J Spinal Cord Med. 2021 May;44(3):411-417. doi: 10.1080/10790268.2019.1666238. Epub 2019 Sep 26.
258 Quantitative evaluation of CXCL8 and its receptors (CXCR1 and CXCR2) gene expression in Iranian patients with multiple sclerosis.Immunol Invest. 2013;42(8):737-48. doi: 10.3109/08820139.2013.812652. Epub 2013 Jul 22.
259 A genetic link between CXCR5 and IL2RA gene polymorphisms and susceptibility to multiple sclerosis.Neurol Res. 2018 Dec;40(12):1040-1047. doi: 10.1080/01616412.2018.1517110.
260 Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis.J Neuroimmunol. 2010 Oct 8;227(1-2):162-6. doi: 10.1016/j.jneuroim.2010.06.003. Epub 2010 Jul 2.
261 Enantioselectivity in the Metabolism of Cyclophosphamide in Patients With Multiple or Systemic Sclerosis.J Clin Pharmacol. 2017 Jun;57(6):784-795. doi: 10.1002/jcph.863. Epub 2017 Jan 13.
262 Expression profiles of cholesterol metabolism-related genes are altered during development of experimental autoimmune encephalomyelitis in the rat spinal cord.Sci Rep. 2017 Jun 2;7(1):2702. doi: 10.1038/s41598-017-02638-8.
263 DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway.J Immunol. 2018 Mar 1;200(5):1618-1626. doi: 10.4049/jimmunol.1601689. Epub 2018 Jan 29.
264 Measurement of the permeability, perfusion, and histogram characteristics in relapsing-remitting multiple sclerosis using dynamic contrast-enhanced MRI with extended Tofts linear model.Neurol India. 2018 May-Jun;66(3):709-715. doi: 10.4103/0028-3886.232324.
265 Leflunomide/teriflunomide inhibit Epstein-Barr virus (EBV)- induced lymphoproliferative disease and lytic viral replication.Oncotarget. 2017 Jul 4;8(27):44266-44280. doi: 10.18632/oncotarget.17863.
266 Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?.Int J Biochem Cell Biol. 2015 Oct;67:49-57. doi: 10.1016/j.biocel.2015.05.010. Epub 2015 May 19.
267 Diversity of V delta-J delta gene rearrangement in peripheral blood lymphocytes and intrathecal IgG synthesis in multiple sclerosis.Folia Neuropathol. 1999;37(2):113-6.
268 DNase hypersensitive sites and association with multiple sclerosis.Hum Mol Genet. 2014 Feb 15;23(4):942-8. doi: 10.1093/hmg/ddt489. Epub 2013 Oct 2.
269 Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation.Brain. 2012 Jun;135(Pt 6):1794-818. doi: 10.1093/brain/aws100. Epub 2012 Apr 28.
270 EGFL7 reduces CNS inflammation in mouse.Nat Commun. 2018 Feb 26;9(1):819. doi: 10.1038/s41467-018-03186-z.
271 Activating transcription factor 6 deficiency exacerbates oligodendrocyte death and myelin damage in immune-mediated demyelinating diseases.Glia. 2018 Jul;66(7):1331-1345. doi: 10.1002/glia.23307. Epub 2018 Feb 13.
272 Identification of the miRNA-mRNA regulatory network in multiple sclerosis.Neurol Res. 2017 Feb;39(2):142-151. doi: 10.1080/01616412.2016.1250857. Epub 2016 Nov 4.
273 Characterization of residue-specific glutathionylation of CSF proteins in multiple sclerosis - A MS-based approach.Anal Biochem. 2019 Jan 1;564-565:108-115. doi: 10.1016/j.ab.2018.10.015. Epub 2018 Oct 24.
274 A functional variant in ERAP1 predisposes to multiple sclerosis.PLoS One. 2012;7(1):e29931. doi: 10.1371/journal.pone.0029931. Epub 2012 Jan 12.
275 Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis.Front Genet. 2018 Feb 16;9:42. doi: 10.3389/fgene.2018.00042. eCollection 2018.
276 Toll-like receptor 4 and protease-activated receptor 2 in physiology and pathophysiology of the nervous system: more than just receptor cooperation?.Neural Regen Res. 2019 Jul;14(7):1196-1201. doi: 10.4103/1673-5374.251290.
277 Association of circulating anti-CD64 IgM levels with favourable long-term clinical outcomes in multiple sclerosis patients.J Neuroimmunol. 2019 May 15;330:130-135. doi: 10.1016/j.jneuroim.2019.03.005. Epub 2019 Mar 8.
278 Selective upregulation of scavenger receptors in and around demyelinating areas in multiple sclerosis.J Neuropathol Exp Neurol. 2013 Feb;72(2):106-18. doi: 10.1097/NEN.0b013e31827fd9e8.
279 Fingolimod Suppresses the Proinflammatory Status of Interferon--Activated Cultured Rat Astrocytes.Mol Neurobiol. 2019 Sep;56(9):5971-5986. doi: 10.1007/s12035-019-1481-x. Epub 2019 Jan 30.
280 Accessible exercise equipment and individuals with multiple sclerosis: Aerobic demands and preferences.NeuroRehabilitation. 2019;45(3):359-367. doi: 10.3233/NRE-192861.
281 Calcitriol, but not FGF23, increases in CSF and serum of MS patients.J Neuroimmunol. 2019 Mar 15;328:89-93. doi: 10.1016/j.jneuroim.2018.12.011. Epub 2018 Dec 30.
282 Assessment of Protein Prenylation Pathway in Multiple Sclerosis Patients.J Mol Neurosci. 2018 Apr;64(4):581-590. doi: 10.1007/s12031-018-1052-z. Epub 2018 Mar 25.
283 Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.J Neuroinflammation. 2019 Dec 3;16(1):252. doi: 10.1186/s12974-019-1612-3.
284 Neurolymphatic biomarkers of brain endothelial inflammatory activation: Implications for multiple sclerosis diagnosis.Life Sci. 2019 Jul 15;229:116-123. doi: 10.1016/j.lfs.2019.05.021. Epub 2019 May 10.
285 The proportion of peripheral regulatory T cells in patients with Multiple Sclerosis: A meta-analysis.Mult Scler Relat Disord. 2019 Feb;28:75-80. doi: 10.1016/j.msard.2018.12.019. Epub 2018 Dec 14.
286 Identification of shared genes and pathways: a comparative study of multiple sclerosis susceptibility, severity and response to interferon beta treatment.PLoS One. 2013;8(2):e57655. doi: 10.1371/journal.pone.0057655. Epub 2013 Feb 28.
287 Enhanced GABAergic Immunoreactivity in Hippocampal Neurons and Astroglia of Multiple Sclerosis Patients.J Neuropathol Exp Neurol. 2019 Jun 1;78(6):480-491. doi: 10.1093/jnen/nlz028.
288 Diagnostic and Clinical Utility of the GAD-2 for Screening Anxiety Symptoms in Individuals With Multiple Sclerosis.Arch Phys Med Rehabil. 2018 Oct;99(10):2045-2049. doi: 10.1016/j.apmr.2018.05.029. Epub 2018 Jun 30.
289 Heterozygous carriers of galactocerebrosidase mutations that cause Krabbe disease have impaired microglial function and defective repair of myelin damage.Neural Regen Res. 2018 Mar;13(3):393-401. doi: 10.4103/1673-5374.228712.
290 Cerebrospinal fluid growth-associated protein 43 in multiple sclerosis.Sci Rep. 2019 Nov 21;9(1):17309. doi: 10.1038/s41598-019-54032-1.
291 Specific Alterations in Astrocyte Properties via the GluA2-GAPDH Complex Associated with Multiple Sclerosis.Sci Rep. 2018 Aug 27;8(1):12856. doi: 10.1038/s41598-018-31318-4.
292 The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.Pharmacol Ther. 2018 Aug;188:97-117. doi: 10.1016/j.pharmthera.2018.03.002. Epub 2018 Mar 4.
293 Serum glial fibrillary acidic protein correlates with multiple sclerosis disease severity.Mult Scler. 2020 Feb;26(2):210-219. doi: 10.1177/1352458518819380. Epub 2018 Dec 20.
294 Oligodendrocyte gap junction loss and disconnection from reactive astrocytes in multiple sclerosis gray matter.J Neuropathol Exp Neurol. 2014 Sep;73(9):865-79. doi: 10.1097/NEN.0000000000000106.
295 Connexin 43/47 channels are important for astrocyte/ oligodendrocyte cross-talk in myelination and demyelination.J Biosci. 2018 Dec;43(5):1055-1068. doi: 10.1007/s12038-018-9811-0.
296 Usefulness of lyso-globotriaosylsphingosine in dried blood spots in the differential diagnosis between multiple sclerosis and Anderson-Fabry's disease.Mult Scler Relat Disord. 2020 Feb;38:101466. doi: 10.1016/j.msard.2019.101466. Epub 2019 Oct 23.
297 A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.PLoS One. 2014 Jun 26;9(6):e100883. doi: 10.1371/journal.pone.0100883. eCollection 2014.
298 EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4T Cells.Cell Rep. 2017 Jan 31;18(5):1270-1284. doi: 10.1016/j.celrep.2017.01.020.
299 Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis.Bioorg Med Chem. 2017 Jan 15;25(2):483-495. doi: 10.1016/j.bmc.2016.11.015. Epub 2016 Nov 18.
300 Glutamate, T cells and multiple sclerosis.J Neural Transm (Vienna). 2017 Jul;124(7):775-798. doi: 10.1007/s00702-016-1661-z. Epub 2017 Feb 24.
301 Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis.PLoS One. 2013 Jun 28;8(6):e67357. doi: 10.1371/journal.pone.0067357. Print 2013.
302 A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population.Mult Scler Relat Disord. 2019 Feb;28:189-192. doi: 10.1016/j.msard.2019.01.012. Epub 2019 Jan 3.
303 Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b(+)Gr-1(+) Myeloid Cells.Front Immunol. 2018 Apr 24;9:873. doi: 10.3389/fimmu.2018.00873. eCollection 2018.
304 Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.Mol Neurobiol. 2018 Oct;55(10):8051-8058. doi: 10.1007/s12035-018-0971-6. Epub 2018 Mar 1.
305 Dimethyl fumarate downregulates the immune response through the HCA(2)/GPR109A pathway: Implications for the treatment of multiple sclerosis.Mult Scler Relat Disord. 2018 Jul;23:46-50. doi: 10.1016/j.msard.2018.04.016. Epub 2018 Apr 25.
306 Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis. Eur J Neurol. 2010 Feb;17(2):335-8.
307 Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis.J Neuroimmunol. 2014 Dec 15;277(1-2):186-8. doi: 10.1016/j.jneuroim.2014.09.018. Epub 2014 Sep 28.
308 Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination.PLoS One. 2017 Dec 18;12(12):e0189380. doi: 10.1371/journal.pone.0189380. eCollection 2017.
309 Levels of 17-hydroxysteroid dehydrogenase type 10 in CSF are not a valuable biomarker for multiple sclerosis.Biomark Med. 2018 Dec;12(12):1331-1340. doi: 10.2217/bmm-2018-0061. Epub 2018 Dec 6.
310 Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis.Clin Exp Immunol. 2018 Nov;194(2):137-152. doi: 10.1111/cei.13186. Epub 2018 Sep 19.
311 Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.J Clin Invest. 2009 Jan;119(1):169-81. doi: 10.1172/JCI35440. Epub 2008 Dec 22.
312 Human fibrocytes express multiple antigens associated with autoimmune endocrine diseases.J Clin Endocrinol Metab. 2014 May;99(5):E796-803. doi: 10.1210/jc.2013-3072. Epub 2014 Feb 11.
313 Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis.J Immunol. 2017 Mar 1;198(5):1900-1909. doi: 10.4049/jimmunol.1601139. Epub 2017 Jan 27.
314 Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood.BMC Genet. 2016 Apr 14;17:59. doi: 10.1186/s12863-016-0367-4.
315 Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.APMIS. 2017 May;125(5):444-451. doi: 10.1111/apm.12659. Epub 2017 Feb 22.
316 T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients.Mult Scler. 2020 Sep;26(10):1172-1186. doi: 10.1177/1352458519852092. Epub 2019 Jun 25.
317 IL-15 amplifies the pathogenic properties of CD4+CD28- T cells in multiple sclerosis.J Immunol. 2015 Mar 1;194(5):2099-109. doi: 10.4049/jimmunol.1401547. Epub 2015 Jan 23.
318 The IL-12 cytokine family in cardiovascular diseases.Cytokine. 2019 Oct;122:154188. doi: 10.1016/j.cyto.2017.10.010. Epub 2017 Oct 23.
319 The combined effect of IL-17F and CCL20 gene polymorphism in susceptibility to multiple sclerosis in Egypt.Gene. 2019 Feb 15;685:164-169. doi: 10.1016/j.gene.2018.11.006. Epub 2018 Nov 3.
320 Impact of interferon -1b, interferon -1a and fingolimod therapies on serum interleukins-22, 32 and 34 concentrations in patients with relapsing-remitting multiple sclerosis.J Neuroimmunol. 2019 Dec 15;337:577062. doi: 10.1016/j.jneuroim.2019.577062. Epub 2019 Sep 6.
321 Clinical and Serological Biomarkers of Treatment's Response in Multiple Sclerosis Patients Treated Continuously with Interferon-1b for More than a Decade.CNS Neurol Disord Drug Targets. 2018;17(10):780-792. doi: 10.2174/1871527317666180917095256.
322 Serum IL-33 Level and IL-33, IL1RL1 Gene Polymorphisms in Asthma and Multiple Sclerosis Patients.Curr Mol Med. 2019;19(5):357-363. doi: 10.2174/1566524019666190405120137.
323 CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.Mol Neurobiol. 2019 Dec;56(12):7977-7993. doi: 10.1007/s12035-019-1640-0. Epub 2019 Jun 2.
324 Th9 cells in the pathogenesis of EAE and multiple sclerosis.Semin Immunopathol. 2017 Jan;39(1):79-87. doi: 10.1007/s00281-016-0604-y. Epub 2016 Nov 14.
325 Association between miRNA-146a and Polymorphisms of its Target Gene, IRAK1, Regarding Susceptibility to and Clinical Features of Systemic Lupus Erythematous and Multiple Sclerosis.Lab Med. 2019 Jan 1;50(1):34-41. doi: 10.1093/labmed/lmy033.
326 FOXP3, CBLB and ITCH gene expression and cytotoxic T lymphocyte antigen 4 expression on CD4(+) CD25(high) T cells in multiple sclerosis.Clin Exp Immunol. 2012 Nov;170(2):149-55. doi: 10.1111/j.1365-2249.2012.04654.x.
327 Effects of intestinal nematode treatment on CD11b activation state in an EAE mouse model of multiple sclerosis.Immunobiology. 2019 Nov;224(6):817-826. doi: 10.1016/j.imbio.2019.08.004. Epub 2019 Aug 13.
328 Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors.Mult Scler. 2016 Dec;22(14):1783-1793. doi: 10.1177/1352458516635873. Epub 2016 Feb 26.
329 Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.J Immunol. 2007 Oct 1;179(7):4563-70. doi: 10.4049/jimmunol.179.7.4563.
330 Enhanced accumulation of Kir4.1 protein, but not mRNA, in a murine model of cuprizone-induced demyelination.Brain Res. 2013 Nov 6;1537:340-9. doi: 10.1016/j.brainres.2013.09.024. Epub 2013 Sep 23.
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332 KIR2DL2 inhibitory pathway enhances Th17 cytokine secretion by NK cells in response to herpesvirus infection in multiple sclerosis patients.J Neuroimmunol. 2016 May 15;294:1-5. doi: 10.1016/j.jneuroim.2016.03.007. Epub 2016 Mar 18.
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334 Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release.Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):271-276. doi: 10.1073/pnas.1810020116. Epub 2018 Dec 17.
335 NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.Front Immunol. 2019 Feb 6;10:154. doi: 10.3389/fimmu.2019.00154. eCollection 2019.
336 Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis.Biochem Genet. 2019 Jun;57(3):355-370. doi: 10.1007/s10528-018-9894-1. Epub 2018 Nov 19.
337 Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.J Neurol. 1995 Oct;242(10):677-82. doi: 10.1007/BF00866919.
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340 Meta-analysis of the IL23R and IL12B polymorphisms in multiple sclerosis.Int J Neurosci. 2016;126(3):205-12. doi: 10.3109/00207454.2015.1007508. Epub 2015 Jun 16.
341 Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model.Neurotherapeutics. 2017 Jan;14(1):199-211. doi: 10.1007/s13311-016-0480-0.
342 Discovery of Enhancers of the Secretion of Leukemia Inhibitory Factor for the Treatment of Multiple Sclerosis.J Biomol Screen. 2016 Jun;21(5):437-45. doi: 10.1177/1087057116638821. Epub 2016 Mar 16.
343 Interferon beta and vitamin D synergize to induce immunoregulatory receptors on peripheral blood monocytes of multiple sclerosis patients.PLoS One. 2014 Dec 31;9(12):e115488. doi: 10.1371/journal.pone.0115488. eCollection 2014.
344 Genetic basis for relapse rate in multiple sclerosis: Association with LRP2 genetic variation.Mult Scler. 2018 Nov;24(13):1773-1775. doi: 10.1177/1352458517749894. Epub 2018 Jan 5.
345 The identification of up-regulated ebv-miR-BHRF1-2-5p targeting MALT1 and ebv-miR-BHRF1-3 in the circulation of patients with multiple sclerosis.Clin Exp Immunol. 2017 Jul;189(1):120-126. doi: 10.1111/cei.12954. Epub 2017 Mar 28.
346 Developing a crosswalk between the RAND-12 and the health utilities index for multiple sclerosis.Mult Scler. 2020 Aug;26(9):1102-1110. doi: 10.1177/1352458519852722. Epub 2019 Jun 4.
347 Reduced disease severity following therapeutic treatment with angiotensin 1-7 in a mouse model of multiple sclerosis.Neurobiol Dis. 2019 Jul;127:87-100. doi: 10.1016/j.nbd.2019.02.018. Epub 2019 Feb 25.
348 Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.Sci Adv. 2016 Jun 17;2(6):e1501678. doi: 10.1126/sciadv.1501678. eCollection 2016 Jun.
349 Matrine alleviates astrogliosis through sphingosine 1-phosphate signaling in experimental autoimmune encephalomyelitis.Neurosci Lett. 2020 Jan 10;715:134599. doi: 10.1016/j.neulet.2019.134599. Epub 2019 Nov 10.
350 Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype.Front Immunol. 2019 Oct 4;10:2312. doi: 10.3389/fimmu.2019.02312. eCollection 2019.
351 Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.J Neuroinflammation. 2018 Aug 22;15(1):236. doi: 10.1186/s12974-018-1276-4.
352 Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.PLoS Genet. 2016 Mar 18;12(3):e1005853. doi: 10.1371/journal.pgen.1005853. eCollection 2016 Mar.
353 Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.Genes Immun. 2014 Apr;15(4):218-23. doi: 10.1038/gene.2014.7. Epub 2014 Feb 27.
354 Multiplex Matrix Metalloproteinases Analysis in the Cerebrospinal Fluid Reveals Potential Specific Patterns in Multiple Sclerosis Patients.Front Neurol. 2018 Dec 18;9:1080. doi: 10.3389/fneur.2018.01080. eCollection 2018.
355 Metabolic defects in multiple sclerosis.Mitochondrion. 2019 Jan;44:7-14. doi: 10.1016/j.mito.2017.12.005. Epub 2017 Dec 13.
356 Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.Genes Immun. 2009 Oct;10(7):631-5. doi: 10.1038/gene.2009.56. Epub 2009 Aug 6.
357 Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients.J Neuroimmunol. 2012 Sep 15;250(1-2):106-10. doi: 10.1016/j.jneuroim.2012.05.014. Epub 2012 Jun 13.
358 Are natural killer cells involved in multiple sclerosis etiology? Evidences from NKp46/NCR1 receptor modulation in an observational study.J Neurol Sci. 2014 Oct 15;345(1-2):248-51. doi: 10.1016/j.jns.2014.07.045. Epub 2014 Jul 30.
359 Relationship between thiol-disulphide homeostasis and visual evoked potentials in patients with multiple sclerosis.Neurol Sci. 2019 Feb;40(2):385-391. doi: 10.1007/s10072-018-3660-3. Epub 2018 Dec 1.
360 Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis.J Cell Biochem. 2019 Apr;120(4):5160-5168. doi: 10.1002/jcb.27792. Epub 2018 Oct 15.
361 NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.PLoS Biol. 2019 Sep 16;17(9):e3000451. doi: 10.1371/journal.pbio.3000451. eCollection 2019 Sep.
362 Nicotinamide nucleotide transhydrogenase expression analysis in multiple sclerosis patients.Int J Neurosci. 2019 Dec;129(12):1256-1260. doi: 10.1080/00207454.2019.1660655. Epub 2019 Sep 2.
363 Peak width of skeletonized mean diffusivity (PSMD) as marker of widespread white matter tissue damage in multiple sclerosis.Mult Scler Relat Disord. 2019 Jan;27:294-297. doi: 10.1016/j.msard.2018.11.011. Epub 2018 Nov 13.
364 A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese.Mult Scler. 2013 Nov;19(13):1696-703. doi: 10.1177/1352458513482512. Epub 2013 Apr 2.
365 No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.Hum Mol Genet. 2014 Apr 1;23(7):1916-22. doi: 10.1093/hmg/ddt574. Epub 2013 Nov 13.
366 Deletion of the Mineralocorticoid Receptor in Myeloid Cells Attenuates Central Nervous System Autoimmunity.Front Immunol. 2017 Oct 13;8:1319. doi: 10.3389/fimmu.2017.01319. eCollection 2017.
367 Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis.Neurosci Lett. 2017 May 10;649:100-106. doi: 10.1016/j.neulet.2017.04.005. Epub 2017 Apr 6.
368 Netrin-1 and multiple sclerosis: a new biomarker for neuroinflammation?.Eur J Neurol. 2017 Sep;24(9):1108-1115. doi: 10.1111/ene.13340. Epub 2017 Jul 5.
369 The role of vitamin D and P2X7R in multiple sclerosis.J Neuroimmunol. 2019 May 15;330:159-169. doi: 10.1016/j.jneuroim.2019.03.004. Epub 2019 Mar 14.
370 Necrostatin-1 ameliorates the pathogenesis of experimental autoimmune encephalomyelitis by suppressing apoptosis and necroptosis of oligodendrocyte precursor cells.Exp Ther Med. 2019 Nov;18(5):4113-4119. doi: 10.3892/etm.2019.8005. Epub 2019 Sep 13.
371 PDCD1 PD-1.3 polymorphism and allergic bronchial asthma in Russian and Buryat patients.J Asthma. 2017 Jan 2;54(1):46-52. doi: 10.1080/02770903.2016.1196366. Epub 2016 Jun 10.
372 InCl(3) mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis.Eur J Med Chem. 2019 Jul 15;174:198-215. doi: 10.1016/j.ejmech.2019.04.020. Epub 2019 Apr 16.
373 Promoting in vivo remyelination with small molecules: a neuroreparative pharmacological treatment for Multiple Sclerosis.Sci Rep. 2017 Mar 3;7:43545. doi: 10.1038/srep43545.
374 Significance of elevated Prohibitin 1 levels in Multiple Sclerosis patients lymphocytes towards the assessment of subclinical disease activity and its role in the central nervous system pathology of disease.Int J Biol Macromol. 2018 Apr 15;110:573-581. doi: 10.1016/j.ijbiomac.2017.12.061. Epub 2017 Dec 11.
375 Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.Cell. 2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j.cell.2019.11.016. Epub 2019 Dec 5.
376 Phospholipase D1 expression analysis in relapsing-remitting multiple sclerosis patients.Neurol Sci. 2017 May;38(5):865-872. doi: 10.1007/s10072-017-2857-1. Epub 2017 Feb 22.
377 Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML.J Neurol. 2018 Aug;265(8):1880-1882. doi: 10.1007/s00415-018-8931-7. Epub 2018 Jun 15.
378 Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.Metab Brain Dis. 2015 Feb;30(1):57-65. doi: 10.1007/s11011-014-9558-8. Epub 2014 May 9.
379 NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms.Biochim Biophys Acta Proteins Proteom. 2019 Jul-Aug;1867(7-8):663-676. doi: 10.1016/j.bbapap.2019.05.002. Epub 2019 May 12.
380 Anemoside A3 ameliorates experimental autoimmune encephalomyelitis by modulating T helper 17 cell response.PLoS One. 2017 Jul 31;12(7):e0182069. doi: 10.1371/journal.pone.0182069. eCollection 2017.
381 Microsomal Prostaglandin E Synthase-1 Facilitates an Intercellular Interaction between CD4?T Cells through IL-1 Autocrine Function in Experimental Autoimmune Encephalomyelitis.Int J Mol Sci. 2017 Dec 19;18(12):2758. doi: 10.3390/ijms18122758.
382 MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2).Biochem Biophys Res Commun. 2017 May 6;486(3):759-766. doi: 10.1016/j.bbrc.2017.03.115. Epub 2017 Mar 23.
383 Impact of vitamin A supplementation on RAR gene expression in multiple sclerosis patients.J Mol Neurosci. 2013 Oct;51(2):478-84. doi: 10.1007/s12031-013-0090-9. Epub 2013 Aug 17.
384 EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.PLoS One. 2015 Apr 8;10(4):e0119605. doi: 10.1371/journal.pone.0119605. eCollection 2015.
385 miR-455-5p downregulation promotes inflammation pathways in the relapse phase of relapsing-remitting multiple sclerosis disease.Immunogenetics. 2019 Feb;71(2):87-95. doi: 10.1007/s00251-018-1087-x. Epub 2018 Oct 11.
386 Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.Cell Death Dis. 2018 Oct 17;9(11):1061. doi: 10.1038/s41419-018-1118-4.
387 A genome-wide association study of brain lesion distribution in multiple sclerosis.Brain. 2013 Apr;136(Pt 4):1012-24. doi: 10.1093/brain/aws363. Epub 2013 Feb 13.
388 SPG2 mimicking multiple sclerosis in a family identified using next generation sequencing.J Neurol Sci. 2017 Apr 15;375:198-202. doi: 10.1016/j.jns.2017.01.069. Epub 2017 Jan 27.
389 The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker.Pharmacogenomics J. 2020 Apr;20(2):271-276. doi: 10.1038/s41397-019-0114-0. Epub 2019 Oct 24.
390 Up-regulation of PGC-1 in neurons protects against experimental autoimmune encephalomyelitis.FASEB J. 2019 Dec;33(12):14811-14824. doi: 10.1096/fj.201901149RR. Epub 2019 Nov 13.
391 Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.Genet Epidemiol. 2019 Oct;43(7):844-863. doi: 10.1002/gepi.22242. Epub 2019 Aug 13.
392 Nogo receptor 1 regulates Caspr distribution at axo-glial units in the central nervous system.Sci Rep. 2017 Aug 21;7(1):8958. doi: 10.1038/s41598-017-09405-9.
393 Is There Any Relevance Between Serum Heavy Metal Concentration and BBB Leakage in Multiple Sclerosis Patients?.Biol Trace Elem Res. 2019 Aug;190(2):289-294. doi: 10.1007/s12011-018-1553-1. Epub 2018 Oct 27.
394 Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents.Pain. 2020 Jan;161(1):177-184. doi: 10.1097/j.pain.0000000000001697.
395 Inactivation of sphingosine-1-phosphate receptor 2 (S1PR2) decreases demyelination and enhances remyelination in animal models of multiple sclerosis.Neurobiol Dis. 2019 Apr;124:189-201. doi: 10.1016/j.nbd.2018.11.018. Epub 2018 Nov 22.
396 Spotlight on siponimod and its potential in the treatment of secondary progressive multiple sclerosis: the evidence to date.Drug Des Devel Ther. 2017 Nov 2;11:3153-3157. doi: 10.2147/DDDT.S122249. eCollection 2017.
397 Channelopathy-related SCN10A gene variants predict cerebellar dysfunction in multiple sclerosis.Neurology. 2016 Feb 2;86(5):410-7. doi: 10.1212/WNL.0000000000002326. Epub 2016 Jan 6.
398 Mucosal Administration of E-selectin Limits Disability in Models of Multiple Sclerosis.Front Mol Neurosci. 2019 Aug 27;12:190. doi: 10.3389/fnmol.2019.00190. eCollection 2019.
399 Semaphorin-3A as An Immune Modulator Is Suppressed by MicroRNA-145-5p.Cell J. 2018 Apr;20(1):113-119. doi: 10.22074/cellj.2018.4842. Epub 2017 Dec 1.
400 Cerebrospinal fluid complement system biomarkers in demyelinating disease.Mult Scler. 2020 Dec;26(14):1929-1937. doi: 10.1177/1352458519887905. Epub 2019 Nov 8.
401 Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.J Neuroinflammation. 2017 Jan 23;14(1):19. doi: 10.1186/s12974-016-0788-z.
402 Salt, inflammatory joint disease, and autoimmunity.Joint Bone Spine. 2018 Jul;85(4):411-416. doi: 10.1016/j.jbspin.2017.06.003. Epub 2017 Jun 23.
403 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
404 Insights in pathogenesis of multiple sclerosis: nitric oxide may induce mitochondrial dysfunction of oligodendrocytes.Rev Neurosci. 2018 Jan 26;29(1):39-53. doi: 10.1515/revneuro-2017-0033.
405 Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis.J Clin Invest. 2019 May 21;129(8):3277-3292. doi: 10.1172/JCI124012.
406 Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis.Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):317-323. doi: 10.1016/j.bbadis.2017.09.024. Epub 2017 Sep 28.
407 Remotely Supervised Transcranial Direct Current Stimulation Increases the Benefit of At-Home Cognitive Training in Multiple Sclerosis.Neuromodulation. 2018 Jun;21(4):383-389. doi: 10.1111/ner.12583. Epub 2017 Feb 22.
408 Polymorphisms in the genes coding for iron binding and transporting proteins are associated with disability, severity, and early progression in multiple sclerosis.BMC Med Genet. 2012 Aug 10;13:70. doi: 10.1186/1471-2350-13-70.
409 Absence of system x(c)(-) on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.J Neuroinflammation. 2017 Jan 13;14(1):9. doi: 10.1186/s12974-016-0787-0.
410 Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis.Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30.
411 Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple Sclerosis.Balkan Med J. 2019 May 10;36(3):174-178. doi: 10.4274/balkanmedj.galenos.2018.2017.1034. Epub 2018 Dec 24.
412 MicroRNA-142 regulates inflammation and T cell differentiation in an animal model of multiple sclerosis.J Neuroinflammation. 2017 Mar 16;14(1):55. doi: 10.1186/s12974-017-0832-7.
413 Role of Sortilin in Models of Autoimmune Neuroinflammation.J Immunol. 2015 Dec 15;195(12):5762-9. doi: 10.4049/jimmunol.1403156. Epub 2015 Nov 13.
414 Immunohistochemical Detection of Sphingosine-1-Phosphate and Sphingosine Kinase-1 in Human Tissue Samples and Cell Lines.Methods Mol Biol. 2018;1697:43-56. doi: 10.1007/7651_2017_44.
415 FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice.J Lipid Res. 2019 Jul;60(7):1311-1322. doi: 10.1194/jlr.M093799. Epub 2019 May 20.
416 Increased plasma levels of mitochondrial DNA and pro-inflammatory cytokines in patients with progressive multiple sclerosis.J Neuroimmunol. 2020 Jan 15;338:577107. doi: 10.1016/j.jneuroim.2019.577107. Epub 2019 Nov 7.
417 The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity.Nat Commun. 2016 Jul 15;7:12073. doi: 10.1038/ncomms12073.
418 TIRC7 and HLA-DR axis contributes to inflammation in multiple sclerosis.Mult Scler. 2014 Aug;20(9):1171-81. doi: 10.1177/1352458514521516. Epub 2014 Feb 13.
419 Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.Sci Rep. 2017 Jan 24;7:41271. doi: 10.1038/srep41271.
420 Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-s, Claudin-11, and Matrix Metalloproteinase-2.Cell Mol Neurobiol. 2016 Aug;36(6):865-872. doi: 10.1007/s10571-015-0270-y. Epub 2016 Jan 14.
421 Dopaminergic modulation of CD4+CD25(high) regulatory T lymphocytes in multiple sclerosis patients during interferon- therapy.Neuroimmunomodulation. 2012;19(5):283-92. doi: 10.1159/000336981. Epub 2012 Apr 3.
422 A Fas(hi) Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation.Front Immunol. 2017 Feb 14;8:97. doi: 10.3389/fimmu.2017.00097. eCollection 2017.
423 Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis.Front Immunol. 2019 Apr 30;10:835. doi: 10.3389/fimmu.2019.00835. eCollection 2019.
424 Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.J Neuroimmunol. 2017 Apr 15;305:131-134. doi: 10.1016/j.jneuroim.2017.02.008. Epub 2017 Feb 7.
425 Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis.Autoimmun Rev. 2020 Jan;19(1):102430. doi: 10.1016/j.autrev.2019.102430. Epub 2019 Nov 15.
426 Plasmocytoid dendritic cell deficit of early response to toll-like receptor 7 agonist stimulation in multiple sclerosis patients.Clin Immunol. 2014 Jul;153(1):211-9. doi: 10.1016/j.clim.2014.04.016. Epub 2014 May 9.
427 1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo.PLoS One. 2013;8(3):e58808. doi: 10.1371/journal.pone.0058808. Epub 2013 Mar 14.
428 Multiple sclerosis-like diagnosis as a complication of previously treated malaria in an iron and vitamin D deficient Nigerian patient.Metab Brain Dis. 2016 Feb;31(1):197-204. doi: 10.1007/s11011-015-9788-4. Epub 2016 Jan 8.
429 Expression of TWEAK and its receptor Fn14 in the multiple sclerosis brain: implications for inflammatory tissue injury.J Neuropathol Exp Neurol. 2008 Dec;67(12):1137-48. doi: 10.1097/NEN.0b013e31818dab90.
430 B cells in MS and NMO: pathogenesis and therapy.Semin Immunopathol. 2014 May;36(3):339-50. doi: 10.1007/s00281-014-0424-x. Epub 2014 May 16.
431 Effect of natalizumab on circulating CD4+ T-cells in multiple sclerosis.PLoS One. 2012;7(11):e47578. doi: 10.1371/journal.pone.0047578. Epub 2012 Nov 30.
432 High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis.J Transl Med. 2019 Feb 20;17(1):51. doi: 10.1186/s12967-019-1789-3.
433 Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis.Clin Immunol. 2018 Feb;187:95-101. doi: 10.1016/j.clim.2017.10.009. Epub 2017 Oct 25.
434 Gene expression profiles of TNF-like cytokine 1A (TL1A) and its receptors death receptor 3 (DR3) and decoy receptor 3 (DcR3) in multiple sclerosis.J Neuroimmunol. 2019 Oct 15;335:577020. doi: 10.1016/j.jneuroim.2019.577020. Epub 2019 Aug 14.
435 Prevalence of celiac disease in multiple sclerosis.BMC Neurol. 2011 Mar 7;11:31. doi: 10.1186/1471-2377-11-31.
436 Tripeptidyl-peptidase II: Update on an oldie that still counts.Biochimie. 2019 Nov;166:27-37. doi: 10.1016/j.biochi.2019.05.012. Epub 2019 May 17.
437 Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.J Pathol. 2019 Apr;247(4):471-480. doi: 10.1002/path.5205. Epub 2019 Jan 30.
438 TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.J Neurosci. 2018 Sep 26;38(39):8484-8495. doi: 10.1523/JNEUROSCI.2203-17.2018. Epub 2018 Sep 10.
439 The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response.FASEB J. 2018 Mar;32(3):1236-1249. doi: 10.1096/fj.201700552R. Epub 2018 Jan 3.
440 Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [(18)F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter.Mol Imaging Biol. 2019 Oct;21(5):935-944. doi: 10.1007/s11307-019-01323-8.
441 Substrate specificity of IgGs with peroxidase and oxidoreductase activities from sera of patients with systemic lupus erythematosus and multiple sclerosis.J Mol Recognit. 2019 Dec;32(12):e2807. doi: 10.1002/jmr.2807. Epub 2019 Aug 6.
442 The TAM receptor TYRO3 is a critical regulator of myelin thickness in the central nervous system.Glia. 2018 Oct;66(10):2209-2220. doi: 10.1002/glia.23481. Epub 2018 Sep 12.
443 Plasma VCAM1 levels correlate with disease severity in Parkinson's disease.J Neuroinflammation. 2019 May 8;16(1):94. doi: 10.1186/s12974-019-1482-8.
444 A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis.J Neuroinflammation. 2019 Jul 30;16(1):161. doi: 10.1186/s12974-019-1548-7.
445 Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves.FASEB J. 2008 Aug;22(8):2970-80. doi: 10.1096/fj.08-106666. Epub 2008 Apr 15.
446 Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination.Mult Scler. 2008 Jun;14(5):577-94. doi: 10.1177/1352458507087468.
447 Genetic association between polymorphisms in the BTG1 gene and multiple sclerosis.J Neuroimmunol. 2009 Aug 18;213(1-2):142-7. doi: 10.1016/j.jneuroim.2009.05.010. Epub 2009 Jun 9.
448 The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity.Int J Mol Sci. 2017 Nov 2;18(11):2306. doi: 10.3390/ijms18112306.
449 Altered expression patterns of complement factor H and miR-146a genes in acute-chronic phases in experimental autoimmune encephalomyelitis mouse.J Cell Physiol. 2019 Nov;234(11):19842-19851. doi: 10.1002/jcp.28583. Epub 2019 Apr 10.
450 Hygiene hypothesis: innate immunity, malaria and multiple sclerosis.Med Hypotheses. 2008;70(4):819-25. doi: 10.1016/j.mehy.2006.10.069. Epub 2007 Sep 21.
451 Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.Hum Mol Genet. 2010 Nov 1;19(21):4286-95. doi: 10.1093/hmg/ddq328. Epub 2010 Aug 10.
452 The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease.Free Radic Biol Med. 2011 Aug 1;51(3):713-8. doi: 10.1016/j.freeradbiomed.2011.04.043. Epub 2011 May 5.
453 Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease.Int Immunol. 2010 Sep;22(9):729-38. doi: 10.1093/intimm/dxq059. Epub 2010 Aug 3.
454 Dipeptidyl peptidase-4 inhibitors lower the risk of autoimmune disease in patients with type 2 diabetes mellitus: A nationwide population-based cohort study.Br J Clin Pharmacol. 2019 Aug;85(8):1719-1727. doi: 10.1111/bcp.13955. Epub 2019 Jun 4.
455 Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39.BMC Med Genet. 2014 Jun 27;15:73. doi: 10.1186/1471-2350-15-73.
456 Glyoxalase I A111E, paraoxonase 1 Q192R and L55M polymorphisms: susceptibility factors of multiple sclerosis?.Mult Scler. 2007 May;13(4):446-53. doi: 10.1177/13524585070130040201.
457 Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis.PLoS One. 2011;6(12):e29648. doi: 10.1371/journal.pone.0029648. Epub 2011 Dec 27.
458 Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis.Neuropharmacology. 2008 Sep;55(4):491-9. doi: 10.1016/j.neuropharm.2008.06.066. Epub 2008 Jul 8.
459 Progranulin deficiency confers resistance to autoimmune encephalomyelitis in mice.Cell Mol Immunol. 2020 Oct;17(10):1077-1091. doi: 10.1038/s41423-019-0274-5. Epub 2019 Aug 29.
460 Mode of Action of Aspirin in Experimental Autoimmune Encephalomyelitis.DNA Cell Biol. 2019 Jul;38(7):593-596. doi: 10.1089/dna.2019.4814. Epub 2019 May 28.
461 Preliminary study: treatment with intramuscular interferon beta-1a results in increased levels of IL-12R2+ and decreased levels of IL23R+ CD4+ T - Lymphocytes in multiple sclerosis.BMC Neurol. 2011 Dec 19;11:155. doi: 10.1186/1471-2377-11-155.
462 IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.Am J Pathol. 2011 Feb;178(2):794-802. doi: 10.1016/j.ajpath.2010.10.043.
463 Effects of interferon and glatiramer acetate on cytokine patterns in multiple sclerosis patients.Cytokine. 2020 Feb;126:154911. doi: 10.1016/j.cyto.2019.154911. Epub 2019 Nov 12.
464 Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.Ann Neurol. 2018 Jul;84(1):51-63. doi: 10.1002/ana.25263. Epub 2018 Jul 3.
465 Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients.Mol Immunol. 2011 Sep;48(15-16):1896-902. doi: 10.1016/j.molimm.2011.05.018. Epub 2011 Jun 12.
466 Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.Glia. 2018 Feb;66(2):359-378. doi: 10.1002/glia.23249. Epub 2017 Oct 31.
467 Gene-environment interactions in multiple sclerosis: innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway.J Neuroimmunol. 2007 Feb;183(1-2):175-88. doi: 10.1016/j.jneuroim.2006.09.014. Epub 2006 Nov 16.
468 Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects.J Neuroimmunol. 2012 May 15;246(1-2):51-7. doi: 10.1016/j.jneuroim.2012.03.003. Epub 2012 Mar 27.
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488 Oligodendroglial Lineage Cells in Thyroid Hormone-Deprived Conditions.Stem Cells Int. 2019 Apr 30;2019:5496891. doi: 10.1155/2019/5496891. eCollection 2019.
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499 CYP27A1, CYP24A1, and RXR- Polymorphisms, Vitamin D, and Multiple Sclerosis: a Pilot Study.J Mol Neurosci. 2018 Sep;66(1):77-84. doi: 10.1007/s12031-018-1152-9. Epub 2018 Aug 7.
500 Association of CYP2R1 rs10766197 with MS risk and disease progression.J Neurosci Res. 2018 Feb;96(2):297-304. doi: 10.1002/jnr.24133. Epub 2017 Aug 23.
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503 Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling.Brain Behav Immun. 2015 Aug;48:313-25. doi: 10.1016/j.bbi.2015.04.013. Epub 2015 Apr 30.
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533 Seeing function in structure: "incidental" eye findings on OCT in a patient with multiple sclerosis.Mult Scler Relat Disord. 2019 Jun;31:72-73. doi: 10.1016/j.msard.2019.03.019. Epub 2019 Mar 28.
534 PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.J Neurol. 2004 Sep;251(9):1085-8. doi: 10.1007/s00415-004-0485-1.
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536 Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.Curr Top Microbiol Immunol. 2008;321:85-100. doi: 10.1007/978-3-540-75203-5_4.
537 A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members.J Neurol Neurosurg Psychiatry. 2001 Dec;71(6):788-91. doi: 10.1136/jnnp.71.6.788.
538 Decreased interferon- induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis.Acta Neurol Scand. 2017 Sep;136(3):233-238. doi: 10.1111/ane.12715. Epub 2016 Dec 5.
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542 Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients.Cell Mol Neurobiol. 2007 Sep;27(6):695-700. doi: 10.1007/s10571-007-9160-2. Epub 2007 Jul 6.
543 The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.Acta Neurol Scand. 2007 Oct;116(4):231-4. doi: 10.1111/j.1600-0404.2007.00884.x.
544 The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.Genes Immun. 2006 Jun;7(4):327-34. doi: 10.1038/sj.gene.6364303. Epub 2006 Apr 27.
545 Bullous pemphigoid antigen 1 isoforms: potential new target autoantigens in multiple sclerosis?.Br J Dermatol. 2005 Mar;152(3):537-40. doi: 10.1111/j.1365-2133.2004.06338.x.
546 Early B-cell Factor gene association with multiple sclerosis in the Spanish population.BMC Neurol. 2005 Oct 28;5:19. doi: 10.1186/1471-2377-5-19.
547 Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis.Eur J Immunogenet. 2004 Jun;31(3):133-40. doi: 10.1111/j.1365-2370.2004.00456.x.
548 A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.Neuromolecular Med. 2007;9(4):335-9. doi: 10.1007/s12017-007-8014-x. Epub 2007 Oct 13.
549 Detection of autoantibodies to the BTB-kelch protein KLHL7 in cancer sera.Scand J Immunol. 2006 Sep;64(3):325-35. doi: 10.1111/j.1365-3083.2006.01821.x.
550 Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin.Mult Scler. 2004 Apr;10(2):153-7. doi: 10.1191/1352458504ms998oa.
551 Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.J Neuroimmunol. 2006 Oct;179(1-2):108-16. doi: 10.1016/j.jneuroim.2006.06.003. Epub 2006 Aug 24.
552 Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4.FEBS Lett. 2006 Jan 23;580(2):545-52. doi: 10.1016/j.febslet.2005.12.067. Epub 2005 Dec 29.
553 Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis.Scand J Immunol. 2006 Oct;64(4):412-9. doi: 10.1111/j.1365-3083.2006.01796.x.
554 Triosephosphate isomerase- and glyceraldehyde-3-phosphate dehydrogenase-reactive autoantibodies in the cerebrospinal fluid of patients with multiple sclerosis.J Immunol. 2006 Oct 15;177(8):5652-8. doi: 10.4049/jimmunol.177.8.5652.
555 Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients.J Neuroinflammation. 2019 Jun 27;16(1):131. doi: 10.1186/s12974-019-1526-0.
556 Ecotropic Viral Integration Site 5 (EVI5) variants are associated with multiple sclerosis in Iranian population.Mult Scler Relat Disord. 2017 Nov;18:15-19. doi: 10.1016/j.msard.2017.09.011. Epub 2017 Sep 14.
557 Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells.Mol Ther. 2010 Jul;18(7):1373-8. doi: 10.1038/mt.2010.74. Epub 2010 Apr 27.
558 The interferon-induced helicase C domain-containing protein 1 gene variant (rs1990760) as an autoimmune-based pathology susceptibility factor.Immunobiology. 2020 Jan;225(1):151864. doi: 10.1016/j.imbio.2019.10.013. Epub 2019 Nov 5.
559 Differential Expression of Klotho in the Brain and Spinal Cord is Associated with Total Antioxidant Capacity in Mice with Experimental Autoimmune Encephalomyelitis.J Mol Neurosci. 2018 Apr;64(4):543-550. doi: 10.1007/s12031-018-1058-6. Epub 2018 Mar 14.
560 LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.J Exp Med. 2017 Jan;214(1):209-226. doi: 10.1084/jem.20160068.
561 Polymerase-1 pathway activation in acute multiple sclerosis relapse.Autoimmun Rev. 2018 Dec;17(12):1235-1239. doi: 10.1016/j.autrev.2018.07.006. Epub 2018 Oct 11.
562 THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study.Neurol Sci. 2018 Jan;39(1):97-102. doi: 10.1007/s10072-017-3148-6. Epub 2017 Oct 19.
563 Development of a Selective Inhibitor of Protein Arginine Deiminase 2.J Med Chem. 2017 Apr 13;60(7):3198-3211. doi: 10.1021/acs.jmedchem.7b00274. Epub 2017 Mar 31.
564 RGC-32 and diseases: the first 20years.Immunol Res. 2019 Jun;67(2-3):267-279. doi: 10.1007/s12026-019-09080-0.
565 ABC Transporters in Neurological Disorders: An Important Gateway for Botanical Compounds Mediated Neuro-Therapeutics.Curr Top Med Chem. 2019;19(10):795-811. doi: 10.2174/1568026619666190412121811.
566 Comorbid anxiety, depression, and cognition in MS and other immune-mediated disorders.Neurology. 2019 Jan 28;92(5):e406-e417. doi: 10.1212/WNL.0000000000006854.
567 A critical role for expression of atypical chemokine receptor 2 in multiple sclerosis: A preliminary project.Mult Scler Relat Disord. 2020 Feb;38:101524. doi: 10.1016/j.msard.2019.101524. Epub 2019 Nov 14.
568 Using mixed methods case-series evaluation in the development of a guided self-management hybrid CBT and ACT intervention for multiple sclerosis pain.Disabil Rehabil. 2017 Sep;39(18):1785-1798. doi: 10.1080/09638288.2016.1209580. Epub 2016 Aug 24.
569 The role of orphan G protein-coupled receptors in the pathophysiology of multiple sclerosis: A review.Life Sci. 2019 May 1;224:33-40. doi: 10.1016/j.lfs.2019.03.045. Epub 2019 Mar 20.
570 Myxovirus resistance protein A (MxA) polymorphism is associated with IFN response in Iranian multiple sclerosis patients.Neurol Sci. 2017 Jun;38(6):1093-1099. doi: 10.1007/s10072-017-2935-4. Epub 2017 Apr 6.
571 The multiple sclerosis risk allele within the AHI1 gene is associated with relapses in children and adults.Mult Scler Relat Disord. 2018 Jan;19:161-165. doi: 10.1016/j.msard.2017.10.008. Epub 2017 Oct 14.
572 Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship.Sci Rep. 2017 Nov 6;7(1):14589. doi: 10.1038/s41598-017-14788-w.
573 Role of Inflammasomes in Neuroimmune and Neurodegenerative Diseases: A Systematic Review.Mediators Inflamm. 2018 Apr 17;2018:1549549. doi: 10.1155/2018/1549549. eCollection 2018.
574 Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.Nat Commun. 2016 Apr 13;7:11350. doi: 10.1038/ncomms11350.
575 Multiple sclerosis animal models: a clinical and histopathological perspective.Brain Pathol. 2017 Mar;27(2):123-137. doi: 10.1111/bpa.12454. Epub 2017 Jan 11.
576 AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis.Dev Cell. 2018 Dec 3;47(5):592-607.e6. doi: 10.1016/j.devcel.2018.11.010.
577 AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis.Brain Behav Immun. 2017 May;62:110-123. doi: 10.1016/j.bbi.2017.01.009. Epub 2017 Feb 1.
578 Asymmetry of Brain Excitability: A New Biomarker that Predicts Objective and Subjective Symptoms in Multiple Sclerosis.Behav Brain Res. 2019 Feb 1;359:281-291. doi: 10.1016/j.bbr.2018.11.005. Epub 2018 Nov 6.
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580 Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16955-16960. doi: 10.1073/pnas.1902623116. Epub 2019 Aug 2.
581 A proliferation-inducing ligand-mediated anti-inflammatory response of astrocytes in multiple sclerosis.Ann Neurol. 2019 Mar;85(3):406-420. doi: 10.1002/ana.25415. Epub 2019 Feb 4.
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583 Orthologous proteins of experimental de- and remyelination are differentially regulated in the CSF proteome of multiple sclerosis subtypes.PLoS One. 2018 Aug 16;13(8):e0202530. doi: 10.1371/journal.pone.0202530. eCollection 2018.
584 Expression of the neuroprotective protein aryl hydrocarbon receptor nuclear translocator 2 correlates with neuronal stress and disability in models of multiple sclerosis.J Neuroinflammation. 2018 Sep 19;15(1):270. doi: 10.1186/s12974-018-1290-6.
585 JC polyomavirus expression and bell-shaped regulation of its SF2/ASF suppressor during the follow-up of multiple sclerosis patients treated with natalizumab.J Neurovirol. 2017 Apr;23(2):226-238. doi: 10.1007/s13365-016-0492-x. Epub 2016 Nov 3.
586 Protective C allele of the single-nucleotide polymorphism rs1335532 is associated with strong binding of Ascl2 transcription factor and elevated CD58 expression in B-cells.Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3211-3220. doi: 10.1016/j.bbadis.2018.07.008. Epub 2018 Jul 10.
587 Genomewide admixture study in Mexican Mestizos with multiple sclerosis.Clin Neurol Neurosurg. 2015 Mar;130:55-60. doi: 10.1016/j.clineuro.2014.11.026. Epub 2014 Dec 24.
588 Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology.Neurosci Lett. 2014 Mar 6;562:34-8. doi: 10.1016/j.neulet.2013.12.070. Epub 2014 Jan 7.
589 Contribution of Plasma Membrane Calcium ATPases to neuronal maladaptive responses: Focus on spinal nociceptive mechanisms and neurodegeneration.Neurosci Lett. 2018 Jan 10;663:60-65. doi: 10.1016/j.neulet.2017.08.003. Epub 2017 Aug 2.
590 Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus.Clin Immunol. 2008 Oct;129(1):31-5. doi: 10.1016/j.clim.2008.07.011. Epub 2008 Aug 16.
591 Renin-angiotensin system gene expression and neurodegenerative diseases.J Renin Angiotensin Aldosterone Syst. 2016 Sep 9;17(3):1470320316666750. doi: 10.1177/1470320316666750. Print 2016 Jul.
592 Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.Nat Med. 2014 Oct;20(10):1147-56. doi: 10.1038/nm.3681. Epub 2014 Sep 14.
593 Balanced Bcl-3 expression in murine CD4(+) Tcells is required for generation of encephalitogenic Th17 cells.Eur J Immunol. 2017 Aug;47(8):1335-1341. doi: 10.1002/eji.201746933. Epub 2017 Jun 29.
594 Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.PLoS One. 2013;8(3):e58352. doi: 10.1371/journal.pone.0058352. Epub 2013 Mar 5.
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596 Plasma levels of CTRP-3, CTRP-9 and apelin in women with multiple sclerosis.J Neuroimmunol. 2019 Aug 15;333:576968. doi: 10.1016/j.jneuroim.2019.576968. Epub 2019 May 16.
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599 Release of interleukin-10 and neurotrophic factors in the choroid plexus: possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia.Neural Regen Res. 2018 Oct;13(10):1743-1752. doi: 10.4103/1673-5374.238615.
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602 The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis.Virol J. 2017 Dec 4;14(1):234. doi: 10.1186/s12985-017-0902-6.
603 CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis.J Neuroimmunol. 2019 Aug 15;333:576967. doi: 10.1016/j.jneuroim.2019.576967. Epub 2019 May 16.
604 Elevated Levels of Proinflammatory Cytokines in Cerebrospinal Fluid of Multiple Sclerosis Patients.Front Immunol. 2017 May 18;8:531. doi: 10.3389/fimmu.2017.00531. eCollection 2017.
605 Expression of CD1d by astrocytes corresponds with relative activity in multiple sclerosis lesions.Brain Pathol. 2020 Jan;30(1):26-35. doi: 10.1111/bpa.12733. Epub 2019 Jun 6.
606 Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages.Front Cell Neurosci. 2017 May 4;11:129. doi: 10.3389/fncel.2017.00129. eCollection 2017.
607 Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis.Sci Rep. 2017 Oct 19;7(1):13544. doi: 10.1038/s41598-017-12881-8.
608 Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.J Immunol. 2016 Oct 15;197(8):3038-3048. doi: 10.4049/jimmunol.1600706. Epub 2016 Aug 31.
609 Clinical and experimental evidence for targeting CD6 in immune-based disorders.Autoimmun Rev. 2018 May;17(5):493-503. doi: 10.1016/j.autrev.2017.12.004. Epub 2018 Mar 9.
610 Correlation of geographic distributions of haptoglobin alleles with prevalence of multiple sclerosis (MS) - a narrative literature review.Metab Brain Dis. 2017 Feb;32(1):19-34. doi: 10.1007/s11011-016-9923-x. Epub 2016 Nov 2.
611 Immunity to T cell receptor peptides in multiple sclerosis. III. Preferential immunogenicity of complementarity-determining region 2 peptides from disease-associated T cell receptor BV genes.J Immunol. 1998 Jul 15;161(2):1034-44.
612 Meta-Analysis of Multiple Sclerosis Microarray Data Reveals Dysregulation in RNA Splicing Regulatory Genes.Int J Mol Sci. 2015 Sep 30;16(10):23463-81. doi: 10.3390/ijms161023463.
613 KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions.Glycobiology. 2018 Dec 1;28(12):958-967. doi: 10.1093/glycob/cwy064.
614 Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils.Brain Behav Immun. 2015 May;46:280-92. doi: 10.1016/j.bbi.2015.02.010. Epub 2015 Feb 16.
615 Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.Immunol Cell Biol. 2015 Oct;93(9):825-36. doi: 10.1038/icb.2015.47. Epub 2015 Apr 2.
616 Intravitreal S100B Injection Leads to Progressive Glaucoma Like Damage in Retina and Optic Nerve.Front Cell Neurosci. 2018 Sep 26;12:312. doi: 10.3389/fncel.2018.00312. eCollection 2018.
617 Analysis of CH25H in multiple sclerosis and neuromyelitis optica.J Neuroimmunol. 2016 Feb 15;291:70-2. doi: 10.1016/j.jneuroim.2015.12.014. Epub 2015 Dec 31.
618 Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.Proteomics. 2015 Oct;15(19):3361-9. doi: 10.1002/pmic.201400142. Epub 2015 Sep 8.
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620 The cost of a catheter: An environmental perspective on single use clean intermittent catheterization.Neurourol Urodyn. 2018 Sep;37(7):2204-2208. doi: 10.1002/nau.23562. Epub 2018 Aug 14.
621 Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS.Neurology. 2019 Nov 12;93(20):e1852-e1866. doi: 10.1212/WNL.0000000000008466. Epub 2019 Oct 14.
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624 Cerebrospinal Fluid Cytokine Expression Profile in Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy.Immunol Invest. 2018 Feb;47(2):135-145. doi: 10.1080/08820139.2017.1405978. Epub 2017 Nov 28.
625 Post-mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms.Brain Pathol. 2020 Jan;30(1):106-119. doi: 10.1111/bpa.12760. Epub 2019 Jul 23.
626 C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation.J Clin Invest. 2020 Feb 3;130(2):838-852. doi: 10.1172/JCI125857.
627 Brief Report: Anti-Calponin 3 Autoantibodies: A Newly Identified Specificity in Patients With Sjgren's Syndrome.Arthritis Rheumatol. 2018 Oct;70(10):1610-1616. doi: 10.1002/art.40550. Epub 2018 Sep 3.
628 Differential modulation of the juxtaparanodal complex in Multiple Sclerosis.Mol Cell Neurosci. 2015 Jul;67:93-103. doi: 10.1016/j.mcn.2015.06.005. Epub 2015 Jun 10.
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630 Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes.Sci Rep. 2017 Mar 20;7:44794. doi: 10.1038/srep44794.
631 CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis.Sci Rep. 2019 Sep 16;9(1):13299. doi: 10.1038/s41598-019-49868-6.
632 VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis.Genes Immun. 2017 Jan;18(1):48-56. doi: 10.1038/gene.2016.49. Epub 2017 Jan 5.
633 Chondroitin sulfate -1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis.Neurosci Res. 2016 Jul;108:55-9. doi: 10.1016/j.neures.2016.01.002. Epub 2016 Jan 20.
634 Cathepsin C modulates myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.J Neurochem. 2019 Feb;148(3):413-425. doi: 10.1111/jnc.14581. Epub 2018 Dec 3.
635 A Novel Regulatory Function of Long Non-coding RNAs at Different Levels of Gene Expression in Multiple Sclerosis.J Mol Neurosci. 2019 Mar;67(3):434-440. doi: 10.1007/s12031-018-1248-2. Epub 2019 Jan 4.
636 A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.J Neuroinflammation. 2017 May 10;14(1):103. doi: 10.1186/s12974-017-0874-x.
637 Neuronal vulnerability and multilineage diversity in multiple sclerosis.Nature. 2019 Sep;573(7772):75-82. doi: 10.1038/s41586-019-1404-z. Epub 2019 Jul 17.
638 The gender-specific association of CXCL16 A181V gene polymorphism with susceptibility to multiple sclerosis, and its effects on PBMC mRNA and plasma soluble CXCL16 levels: preliminary findings.J Neurol. 2014 Aug;261(8):1544-51. doi: 10.1007/s00415-014-7379-7. Epub 2014 May 23.
639 Increased CD74 binding and EAE treatment efficacy of a modified DR1 molecular construct.Metab Brain Dis. 2019 Feb;34(1):153-164. doi: 10.1007/s11011-018-0331-2. Epub 2018 Oct 23.
640 Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk.Cell. 2017 Mar 23;169(1):72-84.e13. doi: 10.1016/j.cell.2017.03.007.
641 The Toll-like Receptor 2 (TLR2)-related Immunopathological Responses in the Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.Iran J Allergy Asthma Immunol. 2019 Jun 8;18(3):230-250. doi: 10.18502/ijaai.v18i3.1117.
642 Early Detection of Biofouling on Water Purification Membranes by Ambient Ionization Mass Spectrometry Imaging.Anal Chem. 2018 Jan 2;90(1):988-997. doi: 10.1021/acs.analchem.7b04236. Epub 2017 Dec 20.
643 Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.Genes Immun. 2013 Jan;14(1):62-6. doi: 10.1038/gene.2012.52. Epub 2012 Nov 15.
644 Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients.J Clin Neurosci. 2015 Jan;22(1):200-3. doi: 10.1016/j.jocn.2014.06.106. Epub 2014 Oct 30.
645 Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.J Neuroimmunol. 2014 Dec 15;277(1-2):140-4. doi: 10.1016/j.jneuroim.2014.09.015. Epub 2014 Sep 28.
646 Immunocytochemical characterization of the expression of inducible and constitutive isoforms of nitric oxide synthase in demyelinating multiple sclerosis lesions.J Neuropathol Exp Neurol. 1997 Jan;56(1):10-20. doi: 10.1097/00005072-199701000-00002.
647 Use of the new oral disease-modifying therapies for multiple sclerosis in British Columbia, Canada: the first five-years.Mult Scler Relat Disord. 2018 Oct;25:57-60. doi: 10.1016/j.msard.2018.07.012. Epub 2018 Jul 9.
648 Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis.BMC Complement Altern Med. 2013 Jun 28;13:149. doi: 10.1186/1472-6882-13-149.
649 Dynamics of Dynamin-Related Protein 1 in Alzheimer's Disease and Other Neurodegenerative Diseases.Cells. 2019 Aug 23;8(9):961. doi: 10.3390/cells8090961.
650 Association between DPP6 polymorphism and the risk of progressive multiple sclerosis in Northern and Southern Europeans.Neurosci Lett. 2012 Nov 21;530(2):155-60. doi: 10.1016/j.neulet.2012.10.008. Epub 2012 Oct 13.
651 Low DPP4 expression and activity in multiple sclerosis.Clin Immunol. 2014 Feb;150(2):170-83. doi: 10.1016/j.clim.2013.11.011. Epub 2013 Nov 28.
652 Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach.PLoS One. 2012;7(7):e40457. doi: 10.1371/journal.pone.0040457. Epub 2012 Jul 11.
653 Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3-C/EBP pathway.Nat Commun. 2015 Sep 16;6:8272. doi: 10.1038/ncomms9272.
654 Integrative analysis revealed potential causal genetic and epigenetic factors for multiple sclerosis.J Neurol. 2019 Nov;266(11):2699-2709. doi: 10.1007/s00415-019-09476-w. Epub 2019 Jul 18.
655 Multiple Sclerosis and EIF2B5: A Paradox or a Missing Link.Adv Exp Med Biol. 2017;958:57-64. doi: 10.1007/978-3-319-47861-6_5.
656 MS CD49d(+)CD154(+) Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration.Cells. 2019 Nov 25;8(12):1508. doi: 10.3390/cells8121508.
657 Chromatin remodeler Ep400 ensures oligodendrocyte survival and is required for myelination in the vertebrate central nervous system.Nucleic Acids Res. 2019 Jul 9;47(12):6208-6224. doi: 10.1093/nar/gkz376.
658 Down-regulation of ERMN expression in relapsing remitting multiple sclerosis.Metab Brain Dis. 2019 Oct;34(5):1261-1266. doi: 10.1007/s11011-019-00429-w. Epub 2019 May 23.
659 Investigation of Endogenous Retrovirus Sequences in the Neighborhood of Genes Up-regulated in a Neuroblastoma Model after Treatment with Hypoxia-Mimetic Cobalt Chloride.Front Microbiol. 2018 Feb 21;9:287. doi: 10.3389/fmicb.2018.00287. eCollection 2018.
660 HERV-W env regulates calcium influx via activating TRPC3 channel together with depressing DISC1 in human neuroblastoma cells.J Neurovirol. 2019 Feb;25(1):101-113. doi: 10.1007/s13365-018-0692-7. Epub 2018 Nov 5.
661 Cladribine - an old newcomer for pulsed immune reconstitution in MS.Nat Rev Neurol. 2017 Oct;13(10):573-574. doi: 10.1038/nrneurol.2017.119. Epub 2017 Sep 8.
662 The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis.Neuroscience. 2019 Jun 15;409:120-129. doi: 10.1016/j.neuroscience.2019.03.050. Epub 2019 Apr 30.
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664 (18)F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis.J Nucl Med. 2020 May;61(5):757-763. doi: 10.2967/jnumed.119.229351. Epub 2019 Oct 25.
665 Linkage analysis and whole exome sequencing identify a novel candidate gene in a Dutch multiple sclerosis family.Mult Scler. 2019 Jun;25(7):909-917. doi: 10.1177/1352458518777202. Epub 2018 Jun 6.
666 Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis.J Neuroinflammation. 2017 Jun 23;14(1):123. doi: 10.1186/s12974-017-0900-z.
667 A genetic study of the FMR1 gene in a Sardinian multiple sclerosis population.Neurol Sci. 2015 Dec;36(12):2213-20. doi: 10.1007/s10072-015-2339-2. Epub 2015 Jul 21.
668 GAS8 and its naturally occurring antisense RNA as biomarkers in multiple sclerosis.Immunobiology. 2019 Jul;224(4):560-564. doi: 10.1016/j.imbio.2019.04.005. Epub 2019 Apr 13.
669 Branching enzyme deficiency: expanding the clinical spectrum.JAMA Neurol. 2014 Jan;71(1):41-7. doi: 10.1001/jamaneurol.2013.4888.
670 Correlation between LincR-Gng2-5'and LincR-Epas1-3'as with the severity of multiple sclerosis in Egyptian patients.Int J Neurosci. 2020 May;130(5):515-521. doi: 10.1080/00207454.2019.1695610. Epub 2019 Dec 2.
671 Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination.Neuroscience. 2017 Sep 1;358:49-57. doi: 10.1016/j.neuroscience.2017.06.006. Epub 2017 Jun 20.
672 GPR65 inhibits experimental autoimmune encephalomyelitis through CD4(+) T cell independent mechanisms that include effects on iNKT cells.Immunol Cell Biol. 2018 Feb;96(2):128-136. doi: 10.1111/imcb.1031. Epub 2017 Dec 19.
673 Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis.J Neurochem. 2019 Feb;148(3):426-439. doi: 10.1111/jnc.14604. Epub 2018 Dec 3.
674 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis.Int J Mol Sci. 2017 Mar 7;18(3):576. doi: 10.3390/ijms18030576.
675 Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis.Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E6065-E6074. doi: 10.1073/pnas.1722041115. Epub 2018 Jun 12.
676 The GTF2I rs117026326 polymorphism is associated with neuromyelitis optica spectrum disorder but not with multiple sclerosis in a Northern Han Chinese population.J Neuroimmunol. 2019 Dec 15;337:577045. doi: 10.1016/j.jneuroim.2019.577045. Epub 2019 Aug 28.
677 Analysis of Lymphocytic DNA Damage in Early Multiple Sclerosis by Automated Gamma-H2AX and 53BP1 Foci Detection: A Case Control Study.PLoS One. 2016 Jan 28;11(1):e0147968. doi: 10.1371/journal.pone.0147968. eCollection 2016.
678 IL7R expression and upregulation by IFN in dendritic cell subsets is haplotype-dependent.PLoS One. 2013 Oct 16;8(10):e77508. doi: 10.1371/journal.pone.0077508. eCollection 2013.
679 Neuregulin1 modulation of experimental autoimmune encephalomyelitis (EAE).J Neuroimmunol. 2018 May 15;318:56-64. doi: 10.1016/j.jneuroim.2018.02.008. Epub 2018 Mar 11.
680 Size-selected silver nanoparticles for MALDI-TOF mass spectrometry of amyloid-beta peptides.Nanoscale. 2018 Nov 29;10(46):22044-22054. doi: 10.1039/c8nr07921h.
681 Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood.Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9318-E9327. doi: 10.1073/pnas.1615715114. Epub 2017 Oct 16.
682 Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis.Mult Scler. 2019 May;25(6):772-782. doi: 10.1177/1352458518770019. Epub 2018 Apr 23.
683 Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.Nat Genet. 2009 Jul;41(7):776-82. doi: 10.1038/ng.401. Epub 2009 Jun 14.
684 Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.J Neuroimmunol. 2016 Sep 15;298:189-93. doi: 10.1016/j.jneuroim.2016.07.011. Epub 2016 Jul 15.
685 Neuronal ICAM-5 Plays a Neuroprotective Role in Progressive Neurodegeneration.Front Neurol. 2019 Mar 12;10:205. doi: 10.3389/fneur.2019.00205. eCollection 2019.
686 Assessing the Metabolomic Profile of Multiple Sclerosis Patients Treated with Interferon Beta 1a by (1)H-NMR Spectroscopy.Neurotherapeutics. 2019 Jul;16(3):797-807. doi: 10.1007/s13311-019-00721-8.
687 Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.J Neuroimmunol. 2012 Apr;245(1-2):98-101. doi: 10.1016/j.jneuroim.2012.02.005. Epub 2012 Mar 2.
688 Theme 5 Human cell biology and pathology.Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(sup1):188-205. doi: 10.1080/21678421.2019.1646993.
689 Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.J Neuroinflammation. 2018 Sep 14;15(1):265. doi: 10.1186/s12974-018-1307-1.
690 Microarray gene expression profiling analysis combined with bioinformatics in multiple sclerosis.Mol Biol Rep. 2013 May;40(5):3731-7. doi: 10.1007/s11033-012-2449-3. Epub 2013 Mar 1.
691 IL17/IL17RA as a Novel Signaling Axis Driving Mesenchymal Stem Cell Therapeutic Function in Experimental Autoimmune Encephalomyelitis.Front Immunol. 2018 Apr 30;9:802. doi: 10.3389/fimmu.2018.00802. eCollection 2018.
692 IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.J Immunol. 2019 Aug 15;203(4):888-898. doi: 10.4049/jimmunol.1900400. Epub 2019 Jul 10.
693 Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.Am J Pathol. 2014 Sep;184(9):2420-9. doi: 10.1016/j.ajpath.2014.05.021. Epub 2014 Aug 13.
694 The impact of treatment adherence on clinical and economic outcomes in multiple sclerosis: Real world evidence from Alberta, Canada.Mult Scler Relat Disord. 2017 Nov;18:218-224. doi: 10.1016/j.msard.2017.10.001. Epub 2017 Oct 6.
695 Common variation near IRF6 is associated with IFN--induced liver injury in multiple sclerosis.Nat Genet. 2018 Aug;50(8):1081-1085. doi: 10.1038/s41588-018-0168-y. Epub 2018 Jul 16.
696 The development of sarcoidosis in patients receiving daclizumab: A case series from multiple clinical trials.Respir Med. 2019 Mar;149:23-27. doi: 10.1016/j.rmed.2019.01.015. Epub 2019 Feb 1.
697 Indications for cellular migration from the central nervous system to its draining lymph nodes in CD11c-GFP(+) bone-marrow chimeras following EAE.Exp Brain Res. 2017 Jul;235(7):2151-2166. doi: 10.1007/s00221-017-4956-x. Epub 2017 Apr 18.
698 -Cyclodextrin-metal organic frameworks as efficient microcontainers for encapsulation of leflunomide and acceleration of its transformation into teriflunomide.Carbohydr Polym. 2019 Jul 15;216:224-230. doi: 10.1016/j.carbpol.2019.04.037. Epub 2019 Apr 9.
699 14-3-3 Proteins regulate K(2P) 5.1 surface expression on T lymphocytes.Traffic. 2017 Jan;18(1):29-43. doi: 10.1111/tra.12455. Epub 2016 Nov 27.
700 Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.Acta Neuropathol Commun. 2014 Oct 3;2:144. doi: 10.1186/s40478-014-0144-4.
701 Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response.Biol Chem. 2014 Sep;395(9):1063-73. doi: 10.1515/hsz-2014-0141.
702 An intermediate level of CD161 expression defines a novel activated, inflammatory, and pathogenic subset of CD8(+) T cells involved in multiple sclerosis.J Autoimmun. 2018 Mar;88:61-74. doi: 10.1016/j.jaut.2017.10.005. Epub 2017 Oct 18.
703 Multiple sclerosis: Presence of serum antibodies to lipids and predominance of cholesterol recognition.J Neurosci Res. 2017 Oct;95(10):1984-1992. doi: 10.1002/jnr.24062. Epub 2017 May 8.
704 Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis.PLoS One. 2017 Jun 26;12(6):e0177472. doi: 10.1371/journal.pone.0177472. eCollection 2017.
705 Safe and effective interferon-beta gene therapy for the treatment of multiple sclerosis by regulating biological activity through the design of interferon-beta-galectin-9 fusion proteins.Int J Pharm. 2018 Jan 30;536(1):310-317. doi: 10.1016/j.ijpharm.2017.12.010. Epub 2017 Dec 5.
706 Silencing Leukocyte Immunoglobulin-Like Receptor A1 in Monocytes Inhibits Inflammation in Mice with Multiple Sclerosis.Neuroimmunomodulation. 2019;26(2):93-101. doi: 10.1159/000495625. Epub 2019 Jan 23.
707 Mutations in the lamin B1 gene are not present in multiple sclerosis.Eur J Neurol. 2009 Apr;16(4):544-6. doi: 10.1111/j.1468-1331.2009.02536.x.
708 Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.JAMA Neurol. 2016 May 1;73(5):520-8. doi: 10.1001/jamaneurol.2015.4807.
709 Close Encounters of the First Kind: Innate Sensors and Multiple Sclerosis.Mol Neurobiol. 2017 Jan;54(1):101-114. doi: 10.1007/s12035-015-9665-5. Epub 2016 Jan 5.
710 Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis.Mol Neurobiol. 2018 Dec;55(12):9307-9327. doi: 10.1007/s12035-018-1049-1. Epub 2018 Apr 17.
711 MRM-MS of marker peptides and their abundance as a tool for authentication of meat species and meat cuts in single-cut meat products.Food Chem. 2019 Jun 15;283:367-374. doi: 10.1016/j.foodchem.2019.01.007. Epub 2019 Jan 8.
712 Hypomorphic MGAT5 polymorphisms promote multiple sclerosis cooperatively with MGAT1 and interleukin-2 and 7 receptor variants.J Neuroimmunol. 2013 Mar 15;256(1-2):71-6. doi: 10.1016/j.jneuroim.2012.12.008. Epub 2013 Jan 22.
713 Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility.Tissue Antigens. 2008 Jul;72(1):54-9. doi: 10.1111/j.1399-0039.2008.01066.x.
714 A Review of Various Antioxidant Compounds and their Potential Utility as Complementary Therapy in Multiple Sclerosis.Nutrients. 2019 Jul 5;11(7):1528. doi: 10.3390/nu11071528.
715 Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis.PLoS One. 2009;4(3):e4952. doi: 10.1371/journal.pone.0004952. Epub 2009 Mar 20.
716 IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.Genes Immun. 2010 Jul;11(5):397-405. doi: 10.1038/gene.2010.28. Epub 2010 Jun 17.
717 The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis.Genes Immun. 2019 Feb;20(2):167-171. doi: 10.1038/s41435-018-0017-0. Epub 2018 Mar 10.
718 Oligodendrocyte degeneration and concomitant microglia activation directs peripheral immune cells into the forebrain.Neurochem Int. 2019 Jun;126:139-153. doi: 10.1016/j.neuint.2019.03.005. Epub 2019 Mar 10.
719 Monodisperse magnetic poly(glycidyl methacrylate) microspheres for isolation of autoantibodies with affinity for the 46kDa form of unconventional Myo1C present in autoimmune patients.Mikrochim Acta. 2018 Apr 23;185(5):262. doi: 10.1007/s00604-018-2807-5.
720 Myelin regulatory factor drives remyelination in multiple sclerosis.Acta Neuropathol. 2017 Sep;134(3):403-422. doi: 10.1007/s00401-017-1741-7. Epub 2017 Jun 19.
721 The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition.Exp Brain Res. 2017 Jan;235(1):279-292. doi: 10.1007/s00221-016-4789-z. Epub 2016 Oct 5.
722 Induction of a unique isoform of the NCOA7 oxidation resistance gene by interferon -1b.J Interferon Cytokine Res. 2015 Mar;35(3):186-99. doi: 10.1089/jir.2014.0115. Epub 2014 Oct 20.
723 Variations in mitochondrial DNA copy numbers in MS brains.J Mol Neurosci. 2008 Jul;35(3):283-7. doi: 10.1007/s12031-008-9115-1. Epub 2008 Jun 20.
724 Mitochondrial DNA T4216C and A4917G variations in multiple sclerosis.J Neurol Sci. 2015 Sep 15;356(1-2):55-60. doi: 10.1016/j.jns.2015.04.050. Epub 2015 May 7.
725 Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis.J Neurochem. 2018 Apr;145(2):139-153. doi: 10.1111/jnc.14294. Epub 2018 Feb 19.
726 Elevated levels of autoantibodies targeting the M1 muscarinic acetylcholine receptor and neurofilament medium in sera from subgroups of patients with schizophrenia.J Neuroimmunol. 2014 Apr 15;269(1-2):68-75. doi: 10.1016/j.jneuroim.2014.02.008. Epub 2014 Feb 25.
727 Novel forms of neurofascin 155 in the central nervous system: alterations in paranodal disruption models and multiple sclerosis.Brain. 2010 Feb;133(Pt 2):389-405. doi: 10.1093/brain/awp341. Epub 2010 Feb 3.
728 NFAT1 deficit and NFAT2 deficit attenuate EAE via different mechanisms.Eur J Immunol. 2015 May;45(5):1377-89. doi: 10.1002/eji.201444638. Epub 2015 Feb 19.
729 Disparity between perceived needs and service provision: a cross-sectional study of Italians with multiple sclerosis.Neurol Sci. 2019 Jun;40(6):1137-1144. doi: 10.1007/s10072-019-03780-z. Epub 2019 Feb 27.
730 A single nucleotide polymorphism within Ninjurin 2 is associated with risk of multiple sclerosis.Metab Brain Dis. 2019 Oct;34(5):1415-1419. doi: 10.1007/s11011-019-00460-x. Epub 2019 Jul 10.
731 Variants in NLRP3 and NLRC4 inflammasome associate with susceptibility and severity of multiple sclerosis.Mult Scler Relat Disord. 2019 Apr;29:26-34. doi: 10.1016/j.msard.2019.01.023. Epub 2019 Jan 11.
732 Myelination in Multiple Sclerosis Lesions Is Associated with Regulation of Bone Morphogenetic Protein 4 and Its Antagonist Noggin.Int J Mol Sci. 2019 Jan 3;20(1):154. doi: 10.3390/ijms20010154.
733 Serum NADPH oxidase concentrations and the associations with iron metabolism in relapsing remitting multiple sclerosis.J Trace Elem Med Biol. 2019 Sep;55:39-43. doi: 10.1016/j.jtemb.2019.05.011. Epub 2019 May 25.
734 Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.J Proteome Res. 2017 Mar 3;16(3):1300-1314. doi: 10.1021/acs.jproteome.6b00916. Epub 2017 Feb 9.
735 Interleukin 1 receptor antagonist and 2'-5'-oligoadenylate synthetase-like molecules as novel biomarkers for multiple sclerosis patients in Bahrain.Mult Scler Relat Disord. 2017 Nov;18:1-7. doi: 10.1016/j.msard.2017.09.001. Epub 2017 Sep 8.
736 Glucocorticoid effects on endothelial barrier function in the murine brain endothelial cell line cEND incubated with sera from patients with multiple sclerosis.Mult Scler. 2010 Mar;16(3):293-302. doi: 10.1177/1352458509358189.
737 The role of TPA I/D and PAI-1 4G/5G polymorphisms in multiple sclerosis.Dis Markers. 2014;2014:362708. doi: 10.1155/2014/362708. Epub 2014 Apr 16.
738 Identification of a novel Parkinson's disease locus via stratified genome-wide association study.BMC Genomics. 2014 Feb 10;15:118. doi: 10.1186/1471-2164-15-118.
739 Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics: A Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis.JAMA Neurol. 2017 May 1;74(5):574-582. doi: 10.1001/jamaneurol.2016.5131.
740 Association Between Exposure of Ipratropium and Salmeterol and Diagnosis of Multiple Sclerosis: A Matched Case-control Study.Clin Ther. 2019 Aug;41(8):1477-1485. doi: 10.1016/j.clinthera.2019.04.039. Epub 2019 May 23.
741 OTUB1 inhibits CNS autoimmunity by preventing IFN--induced hyperactivation of astrocytes.EMBO J. 2019 May 15;38(10):e100947. doi: 10.15252/embj.2018100947. Epub 2019 Apr 3.
742 Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis.J Immunol. 2016 May 15;196(10):4338-47. doi: 10.4049/jimmunol.1502440. Epub 2016 Apr 13.
743 Plasma levels of protein C pathway proteins and brain magnetic resonance imaging volumes in multiple sclerosis.Eur J Neurol. 2020 Feb;27(2):235-243. doi: 10.1111/ene.14058. Epub 2019 Sep 8.
744 Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production.Immunity. 2018 Jul 17;49(1):80-92.e7. doi: 10.1016/j.immuni.2018.05.008. Epub 2018 Jun 26.
745 Inhibition of Casein Kinase 2 Protects Oligodendrocytes From Excitotoxicity by Attenuating JNK/p53 Signaling Cascade.Front Mol Neurosci. 2018 Sep 13;11:333. doi: 10.3389/fnmol.2018.00333. eCollection 2018.
746 Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility.Genome Med. 2019 Apr 30;11(1):26. doi: 10.1186/s13073-019-0640-z.
747 PER3 VNTR polymorphism in Multiple Sclerosis: A new insight to impact of sleep disturbances in MS.Mult Scler Relat Disord. 2017 Oct;17:84-86. doi: 10.1016/j.msard.2017.07.005. Epub 2017 Jul 5.
748 Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue.Neurol Res. 2017 Apr;39(4):323-330. doi: 10.1080/01616412.2016.1275460. Epub 2017 Feb 13.
749 PLXNA3 Variant rs5945430 is Associated with Severe Clinical Course in Male Multiple Sclerosis Patients.Neuromolecular Med. 2017 Sep;19(2-3):286-292. doi: 10.1007/s12017-017-8443-0. Epub 2017 May 23.
750 Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis.J Neuroimmunol. 2020 Jan 15;338:577090. doi: 10.1016/j.jneuroim.2019.577090. Epub 2019 Oct 26.
751 Multiparameter MRI quantification of microstructural tissue alterations in multiple sclerosis.Neuroimage Clin. 2019;23:101879. doi: 10.1016/j.nicl.2019.101879. Epub 2019 May 29.
752 A computational approach based on the colored Petri net formalism for studying multiple sclerosis.BMC Bioinformatics. 2019 Dec 10;20(Suppl 6):623. doi: 10.1186/s12859-019-3196-4.
753 Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis.Acta Neuropathol Commun. 2014 Dec 10;2:170. doi: 10.1186/s40478-014-0170-2.
754 Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11.Blood. 2013 Jan 24;121(4):595-603. doi: 10.1182/blood-2012-07-440339. Epub 2012 Nov 16.
755 Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis.J Immunol. 2017 Dec 1;199(11):3748-3756. doi: 10.4049/jimmunol.1700667. Epub 2017 Oct 23.
756 Synthesis and Biological Evaluation of FTY720 (Fingolimod) Derivatives with Aromatic Head Group as Anticancer Agents.Chem Pharm Bull (Tokyo). 2018;66(10):1015-1018. doi: 10.1248/cpb.c18-00065.
757 Abnormal task driven neural oscillations in multiple sclerosis: A visuomotor MEG study.Hum Brain Mapp. 2017 May;38(5):2441-2453. doi: 10.1002/hbm.23531. Epub 2017 Feb 27.
758 QKI-V5 is downregulated in CNS inflammatory demyelinating diseases.Mult Scler Relat Disord. 2020 Apr;39:101881. doi: 10.1016/j.msard.2019.101881. Epub 2019 Dec 4.
759 Homodimer Architecture of QTRT2, the Noncatalytic Subunit of the Eukaryotic tRNA-Guanine Transglycosylase.Biochemistry. 2018 Jul 3;57(26):3953-3965. doi: 10.1021/acs.biochem.8b00294. Epub 2018 Jun 14.
760 Revealing the functions of novel mutations in RAB3GAP1 in Martsolf and Warburg micro syndromes.Am J Med Genet A. 2019 Apr;179(4):579-587. doi: 10.1002/ajmg.a.61065. Epub 2019 Feb 7.
761 Increased seroreactivity to human T cell lymphoma/leukemia virus-related endogenous sequence-1 Gag peptides in patients with human T cell lymphoma/leukemia virus myelopathy.AIDS Res Hum Retroviruses. 2015 Feb;31(2):242-9. doi: 10.1089/AID.2014.0171. Epub 2014 Nov 19.
762 Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis.Sci Rep. 2019 Aug 12;9(1):11664. doi: 10.1038/s41598-019-48087-3.
763 Does the radiologically isolated syndrome exist? A dual-task cost pilot study.Neurol Sci. 2017 Nov;38(11):2007-2013. doi: 10.1007/s10072-017-3094-3. Epub 2017 Aug 22.
764 Monomethyl fumarate treatment impairs maturation of human myeloid dendritic cells and their ability to activate T cells.Mult Scler. 2019 Jan;25(1):63-71. doi: 10.1177/1352458517740213. Epub 2017 Nov 6.
765 Assessment of expression of RELN signaling pathway in multiple sclerosis patients.Immunobiology. 2019 May;224(3):402-407. doi: 10.1016/j.imbio.2019.02.007. Epub 2019 Feb 12.
766 Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation.J Autoimmun. 2019 Jul;101:56-69. doi: 10.1016/j.jaut.2019.04.003. Epub 2019 Apr 19.
767 The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family.J Mol Recognit. 2017 May;30(5). doi: 10.1002/jmr.2600. Epub 2016 Dec 6.
768 Ribosomal protein S6 mRNA is a biomarker upregulated in multiple sclerosis, downregulated by interferon treatment, and affected by season.Mult Scler. 2014 May;20(6):675-85. doi: 10.1177/1352458513507819. Epub 2013 Oct 14.
769 Copy number variation in pediatric multiple sclerosis.Mult Scler. 2013 Jul;19(8):1014-21. doi: 10.1177/1352458512469696. Epub 2012 Dec 13.
770 Cortical M1 plasticity and metaplasticity in patients with multiple sclerosis.Mult Scler Relat Disord. 2020 Feb;38:101494. doi: 10.1016/j.msard.2019.101494. Epub 2019 Nov 5.
771 Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.PLoS One. 2018 Mar 8;13(3):e0193986. doi: 10.1371/journal.pone.0193986. eCollection 2018.
772 Semaphorin 7A as a Potential Therapeutic Target for Multiple Sclerosis.Mol Neurobiol. 2017 Aug;54(6):4820-4831. doi: 10.1007/s12035-016-0154-2. Epub 2016 Oct 6.
773 Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients.Sci Rep. 2019 Aug 19;9(1):11996. doi: 10.1038/s41598-019-48493-7.
774 CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis.Mult Scler. 2018 Mar;24(3):290-300. doi: 10.1177/1352458517698759. Epub 2017 Mar 9.
775 HLA DR2b-binding peptides from human endogenous retrovirus envelope, Epstein-Barr virus and brain proteins in the context of molecular mimicry in multiple sclerosis.Immunol Lett. 2020 Jan;217:15-24. doi: 10.1016/j.imlet.2019.10.017. Epub 2019 Nov 3.
776 Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene.Mult Scler. 2016 May;22(6):733-40. doi: 10.1177/1352458515602338. Epub 2015 Sep 11.
777 SOX10 Single Transcription Factor-Based Fast and Efficient Generation ofOligodendrocytes from Human Pluripotent Stem Cells.Stem Cell Reports. 2018 Feb 13;10(2):655-672. doi: 10.1016/j.stemcr.2017.12.014. Epub 2018 Jan 11.
778 MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.Brain. 2013 Jun;136(Pt 6):1778-82. doi: 10.1093/brain/awt101.
779 Sp3 expression in immune cells: a quantitative study.Lab Invest. 2002 Sep;82(9):1131-8. doi: 10.1097/01.lab.0000029149.38881.84.
780 Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.Genome Med. 2011 Jan 18;3(1):3. doi: 10.1186/gm217.
781 A rare case of SPG11 mutation with multiple sclerosis.Rev Neurol (Paris). 2016 Jun-Jul;172(6-7):389-91. doi: 10.1016/j.neurol.2016.03.006. Epub 2016 May 11.
782 Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation.Neuron. 2017 Dec 20;96(6):1290-1302.e6. doi: 10.1016/j.neuron.2017.11.032.
783 Dysfunctional RNA-binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice.J Neurosci Res. 2020 Apr;98(4):704-717. doi: 10.1002/jnr.24554. Epub 2019 Nov 22.
784 Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.Brain. 2010 Sep;133(9):2603-11. doi: 10.1093/brain/awq192.
785 Synapsin I deletion reduces neuronal damage and ameliorates clinical progression of experimental autoimmune encephalomyelitis.Brain Behav Immun. 2018 Feb;68:197-210. doi: 10.1016/j.bbi.2017.10.018. Epub 2017 Oct 21.
786 Association between synapsin III gene promoter SNPs and multiple sclerosis in Basque patients.Mult Scler. 2009 Jan;15(1):124-8. doi: 10.1177/1352458508096682. Epub 2008 Aug 28.
787 Association of rs1738074 polymorphism of TAGAP gene with susceptibility to multiple sclerosis in the Iranian population.Neurosci Lett. 2017 May 1;648:66-69. doi: 10.1016/j.neulet.2017.03.041. Epub 2017 Mar 27.
788 The three-dimensional structure of human transaldolase.FEBS Lett. 2000 Jun 23;475(3):205-8. doi: 10.1016/s0014-5793(00)01658-6.
789 TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells.Biochim Biophys Acta. 2014 Jul;1842(7):1130-6. doi: 10.1016/j.bbadis.2014.04.010. Epub 2014 Apr 13.
790 Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple Sclerosis.PLoS One. 2016 Jul 20;11(7):e0158327. doi: 10.1371/journal.pone.0158327. eCollection 2016.
791 MicroRNA-590 promotes pathogenic Th17cell differentiation through targeting Tob1 and is associated with multiple sclerosis.Biochem Biophys Res Commun. 2017 Nov 18;493(2):901-908. doi: 10.1016/j.bbrc.2017.09.123. Epub 2017 Sep 23.
792 Increased level of plasma salusin- and salusin- in patients with multiple sclerosis.Mult Scler Relat Disord. 2019 May;30:76-80. doi: 10.1016/j.msard.2019.02.003. Epub 2019 Feb 5.
793 TERC promotes cellular inflammatory response independent of telomerase.Nucleic Acids Res. 2019 Sep 5;47(15):8084-8095. doi: 10.1093/nar/gkz584.
794 TRAF2 is upregulated in relapsing-remitting multiple sclerosis.Neuroimmunomodulation. 2013;20(3):177-83. doi: 10.1159/000346794. Epub 2013 Apr 5.
795 A genome-wide association study in progressive multiple sclerosis.Mult Scler. 2012 Oct;18(10):1384-94. doi: 10.1177/1352458512439118. Epub 2012 Mar 28.
796 Modulation of Tetraspanin 32 (TSPAN32) Expression in T Cell-Mediated Immune Responses and in Multiple Sclerosis.Int J Mol Sci. 2019 Sep 4;20(18):4323. doi: 10.3390/ijms20184323.
797 Generational changes in multiple sclerosis phenotype in North African immigrants in France: A population-based observational study.PLoS One. 2018 Mar 27;13(3):e0194115. doi: 10.1371/journal.pone.0194115. eCollection 2018.
798 Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis.Neuroimmunomodulation. 2010;17(2):120-5. doi: 10.1159/000258695. Epub 2009 Nov 17.
799 APOE genotypes in African American female multiple sclerosis patients.Neurosci Lett. 2007 Feb 27;414(1):51-6. doi: 10.1016/j.neulet.2006.12.049. Epub 2007 Jan 7.
800 Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice.J Neurosci. 2008 Oct 8;28(41):10330-8. doi: 10.1523/JNEUROSCI.2644-08.2008.
801 Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: no correlation with fatigue and sleepiness.J Neurol Sci. 2011 Aug 15;307(1-2):127-31. doi: 10.1016/j.jns.2011.04.024. Epub 2011 May 24.
802 Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients.J Neuroimmunol. 2011 Mar;232(1-2):179-85. doi: 10.1016/j.jneuroim.2010.09.030. Epub 2010 Nov 13.
803 Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.Genes Immun. 2010 Mar;11(2):142-54. doi: 10.1038/gene.2009.82. Epub 2009 Oct 29.
804 CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.J Neuroimmunol. 2007 Oct;190(1-2):72-9. doi: 10.1016/j.jneuroim.2007.07.024. Epub 2007 Sep 6.
805 Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.Brain. 2007 Feb;130(Pt 2):490-501. doi: 10.1093/brain/awl273. Epub 2006 Sep 26.
806 Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice.J Med Chem. 2010 Feb 25;53(4):1741-54. doi: 10.1021/jm901652p.
807 Oxidative Stress Related to Iron Metabolism in Relapsing Remitting Multiple Sclerosis Patients With Low Disability.Front Neurosci. 2019 Feb 11;13:86. doi: 10.3389/fnins.2019.00086. eCollection 2019.
808 CASP-9: A susceptibility locus for multiple sclerosis in Italy.J Neuroimmunol. 2009 May 29;210(1-2):100-3. doi: 10.1016/j.jneuroim.2009.03.013. Epub 2009 Apr 8.
809 CCL genes in multiple sclerosis and systemic lupus erythematosus.J Neuroimmunol. 2008 Aug 30;200(1-2):145-52. doi: 10.1016/j.jneuroim.2008.05.016. Epub 2008 Jul 3.
810 Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis.J Immunol. 2007 Sep 15;179(6):4074-82. doi: 10.4049/jimmunol.179.6.4074.
811 A novel mitochondrial DNA deletion producing progressive external ophthalmoplegia associated with multiple sclerosis.J Clin Neurosci. 2011 Oct;18(10):1318-24. doi: 10.1016/j.jocn.2011.02.019. Epub 2011 Jul 26.
812 DARS2 mutations in mitochondrial leucoencephalopathy and multiple sclerosis.J Med Genet. 2010 Jan;47(1):66-70. doi: 10.1136/jmg.2009.068221. Epub 2009 Jul 9.
813 Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort.J Neuroimmunol. 2017 Apr 15;305:92-95. doi: 10.1016/j.jneuroim.2017.02.009. Epub 2017 Feb 8.
814 Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians.J Neurol Sci. 2011 Jun 15;305(1-2):116-20. doi: 10.1016/j.jns.2011.02.032. Epub 2011 Mar 26.
815 Functional lesional neurosurgery for tremor: a systematic review and meta-analysis.J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):717-726. doi: 10.1136/jnnp-2017-316302. Epub 2018 Jan 11.
816 Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis.J Immunol. 2011 Jul 15;187(2):781-90. doi: 10.4049/jimmunol.1100789. Epub 2011 Jun 10.
817 Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis.Eur J Hum Genet. 2010 May;18(5):618-20. doi: 10.1038/ejhg.2009.213. Epub 2009 Nov 25.
818 Heat Shock Protein 70 and The Risk of Multiple Sclerosis in The Iranian Population.Cell J. 2019 Jan;20(4):599-603. doi: 10.22074/cellj.2019.5620. Epub 2018 Aug 1.
819 Inflammation in the central nervous system and Th17 responses are inhibited by IFN-gamma-Induced IL-18 binding protein.J Immunol. 2010 Aug 15;185(4):2458-66. doi: 10.4049/jimmunol.0902153. Epub 2010 Jul 19.
820 NRAMP1 (SLC11A1) variants: genetic susceptibility to multiple Sclerosis.J Clin Immunol. 2010 Jul;30(4):583-6. doi: 10.1007/s10875-010-9422-5. Epub 2010 Apr 20.
821 RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 Signaling.Sci Rep. 2017 Jun 2;7(1):2683. doi: 10.1038/s41598-017-02857-z.
822 Adaptive Features of Natural Killer Cells in Multiple Sclerosis.Front Immunol. 2019 Oct 15;10:2403. doi: 10.3389/fimmu.2019.02403. eCollection 2019.
823 Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple sclerosis in a co-culture - a preliminary study.Oncotarget. 2016 Nov 8;7(45):72537-72545. doi: 10.18632/oncotarget.12345.
824 Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.J Biol Chem. 2009 Oct 30;284(44):30615-26. doi: 10.1074/jbc.M109.041244. Epub 2009 Sep 2.
825 Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.Nat Commun. 2011;2:334. doi: 10.1038/ncomms1333.
826 Immunomodulatory properties of MSC-derived exosomes armed with high affinity aptamer toward mylein as a platform for reducing multiple sclerosis clinical score.J Control Release. 2019 Apr 10;299:149-164. doi: 10.1016/j.jconrel.2019.02.032. Epub 2019 Feb 23.
827 Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS.Glia. 2007 May;55(7):687-97. doi: 10.1002/glia.20492.
828 mtDNA nt13708A variant increases the risk of multiple sclerosis.PLoS One. 2008 Feb 13;3(2):e1530. doi: 10.1371/journal.pone.0001530.
829 SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients.Genes Immun. 2011 Oct;12(7):523-30. doi: 10.1038/gene.2011.25. Epub 2011 Jun 9.
830 Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis.Hum Genet. 2012 Jan;131(1):87-97. doi: 10.1007/s00439-011-1053-2. Epub 2011 Jul 7.
831 Effects of green tea epigallocatechin-3-gallate on the proteolipid protein and oligodendrocyte transcription factor 1 messenger RNA gene expression in a mouse model of multiple sclerosis.Folia Neuropathol. 2017;55(3):199-205. doi: 10.5114/fn.2017.70484.
832 Distribution of parvalbumin and calretinin immunoreactive interneurons in motor cortex from multiple sclerosis post-mortem tissue.Exp Brain Res. 2008 May;187(3):459-65. doi: 10.1007/s00221-008-1317-9. Epub 2008 Feb 23.
833 Proteomic analysis of human cerebral endothelial cells activated by multiple sclerosis serum and IFNbeta-1b.J Mol Neurosci. 2007;32(3):169-78. doi: 10.1007/s12031-007-0018-3.
834 RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling.Trends Cell Biol. 2017 May;27(5):365-378. doi: 10.1016/j.tcb.2016.11.009. Epub 2016 Dec 19.
835 Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.PLoS One. 2010 Apr 2;5(4):e10003. doi: 10.1371/journal.pone.0010003.
836 Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene.J Neuroimmunol. 2008 Jul 15;197(2):124-7. doi: 10.1016/j.jneuroim.2008.04.003. Epub 2008 Jun 3.
837 HLA and multiple sclerosis: population and families study.Tissue Antigens. 1985 Apr;25(4):187-99. doi: 10.1111/j.1399-0039.1985.tb00436.x.
838 Chipping away at diagnostics for neurodegenerative diseases.Neurobiol Dis. 2009 Aug;35(2):148-56. doi: 10.1016/j.nbd.2009.02.016. Epub 2009 Mar 10.
839 The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis.J Neuroimmunol. 2007 Feb;183(1-2):208-13. doi: 10.1016/j.jneuroim.2006.11.002. Epub 2006 Dec 18.
840 Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis.Mult Scler. 2008 Apr;14(3):412-4. doi: 10.1177/1352458507083780. Epub 2008 Jan 21.
841 TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis.PLoS One. 2011;6(7):e21766. doi: 10.1371/journal.pone.0021766. Epub 2011 Jul 21.
842 TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.Neuropathol Appl Neurobiol. 2007 Feb;33(1):99-107. doi: 10.1111/j.1365-2990.2006.00787.x.