Details of the Drug

General Information of Drug (ID: DM7V8DZ)

• Drug Name: Ribose-1-Phosphate
• Synonyms: ribose 1-phosphate; ribose-1-phosphate; alpha-D-Ribose 1-phosphate; CHEBI:16300; 1-O-phosphono-alpha-D-ribofuranose; alpha-D-ribofuranose 1-(dihydrogen phosphate); D-ribose-1-phosphate; alpha-D-ribose-1-phosphate; alpha-D-ribofuranose 1-phosphate; R1P; D-ribofuranose 1-(dihydrogen phosphate); 14075-00-4; D-ribose-1P; ribofuranose 1-phosphate; a-D-ribose 1-phosphate; D-ribofuranose 1-phosphate; alpha-D-Ribofuranose, 1-(dihydrogen phosphate); 1-phospho-alpha-D-ribofuranose; CHEMBL603367; SCHEMBL1995711; AC1L96Y2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight (mw); 230.11
  Logarithm of the Partition Coefficient (xlogp); -3.1
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 5
  Hydrogen Bond Acceptor Count (hbondacc); 8
• Chemical Identifiers:
  Formula: C5H11O8P
  IUPAC Name: [(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl] dihydrogen phosphate
  Canonical SMILES: C([C@@H]1[C@H]([C@H]([C@H](O1)OP(=O)(O)O)O)O)O
  InChI: InChI=1S/C5H11O8P/c6-1-2-3(7)4(8)5(12-2)13-14(9,10)11/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5-/m1/s1
  InChIKey: YXJDFQJKERBOBM-TXICZTDVSA-N
• Cross-matching ID:
  PubChem CID: 439236
  ChEBI ID: CHEBI:16300
  CAS Number: 14075-00-4
  DrugBank ID: DB03101
  TTD ID: D04LUI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Purine nucleoside phosphorylase (PNP)	TTMCF1Y	PNPH_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Purine nucleoside phosphorylase (PNP)	DTT	PNP	3.67E-04	1.95	2.55

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.