General Information of Drug (ID: DM8J5XT)

Drug Name
Fospropofol
Synonyms
Fospropofol; Fospropofol [INN]; LZ257RZP7K; SCHEMBL3821874; ZINC2519740; 258516-89-1; AC1MI4YI; ACM258516891; CHEBI:135193; CHEMBL1201766; DB06716; DEA No. 2138; DTXSID50870295; FT-0727559; GTPL7475; UNII-LZ257RZP7K; [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 288.28
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Clearance
The total body clearance of drug is 0.28 L/h/kg []
Half-life
The concentration or amount of drug in body reduced by one-half in 0.81 hours [1]
Metabolism
The drug is metabolized via the endothelial alkaline phosphatase []
Vd
The volume of distribution (Vd) of drug is 0.33 +/- 0.069 L/kg []
Chemical Identifiers
Formula
C13H21O5P
IUPAC Name
[2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
Canonical SMILES
CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
InChI
QVNNONOFASOXQV-UHFFFAOYSA-N
InChIKey
1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16)
Cross-matching ID
PubChem CID
3038498
ChEBI ID
CHEBI:135193
CAS Number
258516-89-1
DrugBank ID
DB06716
INTEDE ID
DR0753

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alkaline phosphatase (ALPL)
Main DME
DEVEFKM PPBT_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
2 A double-blind, randomized, multicenter, dose-ranging study to evaluate the safety and efficacy of fospropofol disodium as an intravenous sedative for colonoscopy in high-risk populations. Am J Ther. 2013 Mar-Apr;20(2):163-71.