Details of the Drug

General Information of Drug (ID: DM8J5XT)

Drug Name
Fospropofol
Synonyms
Fospropofol; Fospropofol [INN]; LZ257RZP7K; SCHEMBL3821874; ZINC2519740; 258516-89-1; AC1MI4YI; ACM258516891; CHEBI:135193; CHEMBL1201766; DB06716; DEA No. 2138; DTXSID50870295; FT-0727559; GTPL7475; UNII-LZ257RZP7K; [2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
Affected Organisms
Humans and other mammals
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 288.28
Logarithm of the Partition Coefficient (xlogp) 2.5
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 2
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Clearance
The total body clearance of drug is 0.28 L/h/kg []
Half-life
The concentration or amount of drug in body reduced by one-half in 0.81 hours [1]
Metabolism
The drug is metabolized via the endothelial alkaline phosphatase []
Vd
The volume of distribution (Vd) of drug is 0.33 +/- 0.069 L/kg []
Chemical Identifiers
Formula
C13H21O5P
IUPAC Name
[2,6-di(propan-2-yl)phenoxy]methyl dihydrogen phosphate
Canonical SMILES
CC(C)C1=C(C(=CC=C1)C(C)C)OCOP(=O)(O)O
InChI
InChI=1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16)
InChIKey
QVNNONOFASOXQV-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3038498
ChEBI ID
CHEMBL135193
CAS Number
258516-89-1
UNII
LZ257RZP7K
DrugBank ID
DB06716
INTEDE ID
DR0753
Drug ADMET Endpoint Profile (DAE)NEW Click to Jump to the Detailed DAE Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Alkaline phosphatase (ALPL)
Main DME 		DEVEFKM PPBT_HUMAN Substrate [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
2 A double-blind, randomized, multicenter, dose-ranging study to evaluate the safety and efficacy of fospropofol disodium as an intravenous sedative for colonoscopy in high-risk populations. Am J Ther. 2013 Mar-Apr;20(2):163-71.