Details of the Drug

General Information of Drug (ID: DM8R4YU)

Drug Name

GM-602

Synonyms

Alirinetide; UNII-6BK9OEG8CC; 6BK9OEG8CC; 725715-18-4; GM-603; GM-605; GM-604; GM-607; GM-609; GM-606; L-Arginine, L-phenylalanyl-L-seryl-L-arginyl-L-tyrosyl-L-alanyl-; (2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-(((2S)-2-Amino-3-phenyl-propanoyl)amino)-3-hydroxy-propanoyl)amino)-5-guanidino-pentanoyl)amino)-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)-5-guanidino-pentanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 2	[1]
Amyotrophic lateral sclerosis	8B60.0	Phase 2	[2]
Ischemic stroke	8B11.5Z	Phase 2	[2]
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Structure

3D MOL is unavailable

2D MOL

Chemical Identifiers

Formula: C36H54N12O9
Canonical SMILES: CC(C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CO)NC(=O)C(CC2=CC=CC=C2)N
InChI: 1S/C36H54N12O9/c1-20(29(51)46-26(34(56)57)10-6-16-43-36(40)41)44-32(54)27(18-22-11-13-23(50)14-12-22)47-31(53)25(9-5-15-42-35(38)39)45-33(55)28(19-49)48-30(52)24(37)17-21-7-3-2-4-8-21/h2-4,7-8,11-14,20,24-28,49-50H,5-6,9-10,15-19,37H2,1H3,(H,44,54)(H,45,55)(H,46,51)(H,47,53)(H,48,52)(H,56,57)(H4,38,39,42)(H4,40,41,43)/t20-,24-,25-,26-,27-,28-/m0/s1
InChIKey: WVPOPWDCSFQEBI-HJJAOGADSA-N

Cross-matching ID

PubChem CID: 9875671
CAS Number: 725715-18-4
TTD ID: D02DEH

Repurposed Drugs (RPD)

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References

1	ClinicalTrials.gov (NCT01221246) Efficacy and Safety Study of GM602 in Patients With Acute Middle Cerebral Artery Ischemic Stroke Within 18 Hours. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)