General Information of Drug (ID: DM8V5IH)

Drug Name
1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine
Synonyms
CHEMBL212763; 1-(2-(3-methoxyphenyl)-1-phenylethyl)piperazine; 61311-72-6; 1-[2-(3-Methoxyphenyl)-1-phenylethyl]piperazine; SCHEMBL11504855; CTK2E2732; DTXSID40552210; BDBM50188044; Piperazine, 1-[2-(3-methoxyphenyl)-1-phenylethyl]-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 296.4
Logarithm of the Partition Coefficient (xlogp) 3.1
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C19H24N2O
IUPAC Name
1-[2-(3-methoxyphenyl)-1-phenylethyl]piperazine
Canonical SMILES
COC1=CC=CC(=C1)CC(C2=CC=CC=C2)N3CCNCC3
InChI
InChI=1S/C19H24N2O/c1-22-18-9-5-6-16(14-18)15-19(17-7-3-2-4-8-17)21-12-10-20-11-13-21/h2-9,14,19-20H,10-13,15H2,1H3
InChIKey
CTAHXNUPBZTDFO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
13904719
CAS Number
61311-72-6
TTD ID
D08LAY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Norepinephrine transporter (NET) TTAWNKZ SC6A2_HUMAN Inhibitor [1]
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Serotonin transporter (SERT) DTT SLC6A4 8.76E-01 7.18E-05 6.19E-04
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4345-8.