Details of the Drug

General Information of Drug (ID: DM90J3J)

• Drug Name: Brilaroxazine
• Synonyms: Brilaroxazine; 1239729-06-6; X8L60BA01I; UNII-X8L60BA01I; 6-(4-(4-(2,3-Dichlorophenyl)-piperazin-1-yl)-butoxy)-2H-benzo(b)(1,4)oxazin-3(4H)-one; RP-5063; 2H-1,4-Benzoxazin-3(4H)-one, 6-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-; 6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo(b)(1,4)oxazin-3(4H)-one; 6-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2h-benzo[b][1,4]oxazin-3(4h)-one; 2H-1,4-Benzoxazin-3(4H)-one, 6-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-; 6-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-4H-1,4-benzoxazin-3-one; Brilaroxazin; BRILAROXAZINE [INN]; BRILAROXAZINE [WHO-DD]; SCHEMBL3404085; CHEMBL5095172; BDBM312188; DTXSID001136921; AKOS040741455; DB09226; MS-28159; US9604944, 15b (Example 14); HY-109112; CS-0077721; 6-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-2H-1,4-benzoxazin-3(4H)-one; 2036070-48-9

Indication

Disease Entry	ICD 11	Status	REF
Idiopathic pulmonary fibrosis	CB03.4	Phase 1	[1]
Pulmonary arterial hypertension	BB01.0	Phase 1	[1]

• Drug Type: Small molecule
• Chemical Identifiers:
  Formula: C22H25Cl2N3O3
  Canonical SMILES: C1CN(CCN1CCCCOC2=CC3=C(C=C2)OCC(=O)N3)C4=C(C(=CC=C4)Cl)Cl
  InChI: InChI=1S/C22H25Cl2N3O3/c23-17-4-3-5-19(22(17)24)27-11-9-26(10-12-27)8-1-2-13-29-16-6-7-20-18(14-16)25-21(28)15-30-20/h3-7,14H,1-2,8-13,15H2,(H,25,28)
  InChIKey: PMKMNTBZJOXTJW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 46861612
  TTD ID: D15BZU
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotoninnorepinephrinedopamine reuptake (SNDR)	TT8G3Z7	NOUNIPROTAC	Agonist	[1]

References

• [1] Clinical pipeline report, company report or official report of Reviva Pharmaceuticals