Details of the Drug

General Information of Drug (ID: DM958EN)

• Drug Name: 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine
• Synonyms: 76537-53-6; 8-(1-Piperazinyl)imidazo(1,2-a)pyrazine; 8-(1-piperazinyl)imidazo[1,2-a]pyrazine; CHEMBL331036; 8-piperazin-1-ylimidazo[1,2-a]pyrazine; 8-Pdpr; Imidazo(1,2-a)pyrazine, 8-(1-piperazinyl)-; Imidazo[1,2-a]pyrazine, 8-(1-piperazinyl)-; 8-Piperazin-1-yl-imidazo[1,2-a]pyrazine; AC1L2YVL; 8-(piperazin-1-yl)imidazo[1,2-a]pyrazine; AC1Q4X6M; SCHEMBL5496661; AC1Q1I52; CTK5E3085; DTXSID50227346; ZINC5117657; BDBM50002151; AKOS024075563; FT-0756627; Imidazo[1,2-a]pyrazine,8-(1-piperazinyl)-; A839966

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 203.24
  Logarithm of the Partition Coefficient (xlogp); 0.5
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C10H13N5
  IUPAC Name: 8-piperazin-1-ylimidazo[1,2-a]pyrazine
  Canonical SMILES: C1CN(CCN1)C2=NC=CN3C2=NC=C3
  InChI: InChI=1S/C10H13N5/c1-5-14(6-2-11-1)9-10-13-4-8-15(10)7-3-12-9/h3-4,7-8,11H,1-2,5-6H2
  InChIKey: NSHLOJVJEGEMSF-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 131268
  CAS Number: 76537-53-6
  TTD ID: D0E5CI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	9.43E-01	-0.03	-0.25

References

• [1] Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines. J Med Chem. 1992 Oct 16;35(21):3845-57.