Details of the Drug

General Information of Drug (ID: DM9MPDK)

• Drug Name: 6-Carboxymethyluracil
• Synonyms: 6-Carboxymethyluracil; 4628-39-1; URACIL-6-ACETIC ACID; Uracil-4-acetic acid; (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidineacetic acid; 2-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; uracil-6-ylacetic acid; NSC13201; 4-Pyrimidineacetic acid, 1,2,3,6-tetrahydro-2,6-dioxo-; (2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-acetic acid; CHEBI:46371; 2-(2,6-dihydroxypyrimidin-4-yl)acetic acid; 2-(2,4-dioxo-1H-pyrimidin-6-yl)acetic acid; 4-Pyrimidineaceticacid, 1,2,

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 170.12
  Logarithm of the Partition Coefficient (xlogp); -1.7
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 3
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C6H6N2O4
  IUPAC Name: 2-(2,4-dioxo-1H-pyrimidin-6-yl)acetic acid
  Canonical SMILES: C1=C(NC(=O)NC1=O)CC(=O)O
  InChI: InChI=1S/C6H6N2O4/c9-4-1-3(2-5(10)11)7-6(12)8-4/h1H,2H2,(H,10,11)(H2,7,8,9,12)
  InChIKey: NQAUNZZEYKWTHM-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 73271
  ChEBI ID: CHEBI:46371
  CAS Number: 4628-39-1
  DrugBank ID: DB03048
  TTD ID: D0O0AI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[1]

References

• [1] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.