Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9MPDK)

Drug Name

6-Carboxymethyluracil Drug Info

Synonyms

6-Carboxymethyluracil; 4628-39-1; URACIL-6-ACETIC ACID; Uracil-4-acetic acid; (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidineacetic acid; 2-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetic acid; uracil-6-ylacetic acid; NSC13201; 4-Pyrimidineacetic acid, 1,2,3,6-tetrahydro-2,6-dioxo-; (2,6-Dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl)-acetic acid; CHEBI:46371; 2-(2,6-dihydroxypyrimidin-4-yl)acetic acid; 2-(2,4-dioxo-1H-pyrimidin-6-yl)acetic acid; 4-Pyrimidineaceticacid, 1,2,

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 73271
ChEBI ID: CHEBI:46371
CAS Number: CAS 4628-39-1
TTD Drug ID: DM9MPDK

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Dihydrothymine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[2]
Eniluracil	DM96NCR	Hyperlipidaemia	5C80	Phase 2	[3]
RO-09-4889	DMQ65YW	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
FL-386	DMUQN83	Hyperlipidaemia	5C80	Discontinued in Phase 2	[5]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
5-Iodouracil	DM4O6I5	Discovery agent	N.A.	Investigative	[1]
(5s)-5-Iododihydro-2,4(1h,3h)-Pyrimidinedione	DMA5DO2	Discovery agent	N.A.	Investigative	[1]
Uracil	DMNPO9Q	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dihydrothymine dehydrogenase (DPYD)	TTZPS91	DPYD_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells. Eur J Cancer. 2002 Jun;38(9):1271-7.
3	Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.
4	Single ascending dose tolerability, pharmacokinetic-pharmacodynamic study of dihydropyrimidine dehydrogenase inhibitor Ro 09-4889. Clin Cancer Res. 2004 Apr 1;10(7):2327-35.
5	Effects of FL-386 on faecal lipid excretion in humans. J Int Med Res. 1993 Sep-Oct;21(5):225-33.
6	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.