General Information of Drug (ID: DMAIJC9)

Drug Name
APX-001
Synonyms
EPI-0010; SSS-07; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Apexigen; Anti-TNF alpha recombinant humanized monoclonal antibody (RabMab/MLG, rheumatoid arthritis), 3SBio/Epitomics
Indication
Disease Entry ICD 11 Status REF
Candidemia 1F23.3Y Phase 2 [1]
Rheumatoid arthritis FA20 Investigative [2]
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C22H21N4O6P
Canonical SMILES
C1=CC=NC(=C1)OCC2=CC=C(C=C2)CC3=NOC(=C3)C4=C([N+](=CC=C4)COP(=O)(O)[O-])N
InChI
1S/C22H21N4O6P/c23-22-19(4-3-11-26(22)15-31-33(27,28)29)20-13-18(25-32-20)12-16-6-8-17(9-7-16)14-30-21-5-1-2-10-24-21/h1-11,13,23H,12,14-15H2,(H2,27,28,29)
InChIKey
JQONJQKKVAHONF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44123754
CAS Number
2091769-17-2
TTD ID
D0DL3W
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

References

1 ClinicalTrials.gov (NCT03604705) An Efficacy and Safety Study of APX001 in Non-Neutropenic Patients With Candidemia. U.S. National Institutes of Health.
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.