Details of the Drug

General Information of Drug (ID: DMAQDK9)

Drug Name
5,10-Methylene-6-Hydrofolic Acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 455.4
Logarithm of the Partition Coefficient (xlogp) -1
Rotatable Bond Count (rotbonds) 7
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 10
Chemical Identifiers
Formula
C20H21N7O6
IUPAC Name
(2R)-2-[[4-[(6aS)-3-amino-1-oxo-2,6a,7,9-tetrahydroimidazo[1,5-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid
Canonical SMILES
C1[C@H]2C=NC3=C(N2CN1C4=CC=C(C=C4)C(=O)N[C@H](CCC(=O)O)C(=O)O)C(=O)NC(=N3)N
InChI
InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,7,12-13H,5-6,8-9H2,(H,23,30)(H,28,29)(H,32,33)(H3,21,24,25,31)/t12-,13-/m1/s1
InChIKey
BHJAPJNOACHPNI-CHWSQXEVSA-N
Cross-matching ID
PubChem CID
135403830
DrugBank ID
DB02301
TTD ID
D0A6BH

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.