Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTU6BFZ)

• DTT Name: Candida Thymidylate synthase (Candi TMP1)
• Synonyms: Tsase of Candida albicans; TS of Candida albicans; TMP1; Human recombinant thymidylate synthase; HrTS
• Gene Name: Candi TMP1
• DTT Type: Successful target; [1]
• Related Disease:
  Bacterial infection [ICD-11: 1A00-1C4Z]
  Colon cancer [ICD-11: 2B90]
  Colorectal cancer [ICD-11: 2B91]
  Endocarditis [ICD-11: BB40-BA42]
  Gram-positive bacterial infection [ICD-11: 1B74-1F40]
  Pleural mesothelioma [ICD-11: 2C26]
  Rectum cancer [ICD-11: 2B92]
  Solid tumour/cancer [ICD-11: 2A00-2F9Z]
  Virus infection [ICD-11: 1A24-1D9Z]
• BioChemical Class: Methyltransferase
• UniProt ID: TYSY_CANAL
• TTD ID: T52227
• EC Number: EC 2.1.1.45
• Sequence:
  MTVSPNTAEQAYLDLCKRIIDEGEHRPDRTGTGTKSLFAPPQLRFDLSNDTFPLLTTKKV
  FSKGIIHELLWFVAGSTDAKILSEKGVKIWEGNGSREFLDKLGLTHRREGDLGPVYGFQW
  RHFGAEYKDCDSDYTGQGFDQLQDVIKKLKTNPYDRRIIMSAWNPPDFAKMALPPCHVFC
  QFYVNFPTSSPDPNNPKQAKTAKPKLSCLLYQRSCDMGLGVPFNIASYALLTKMIAHVVD
  MDCGEFIHTLGDAHVYLDHIDALKEQFERIPKQFPKLVIKEERKNEIKSIDDFKFEDFEI
  VGYEPYPPIKMKMSV
• Function: Contributes to thede novo mitochondrial thymidylate biosynthesis pathway.
• KEGG Pathway:
  Pyrimidine metabolism (hsa00240)
  One carbon pool by folate (hsa00670)
  Metabolic pathways (hsa01100)
• Reactome Pathway:
  Pyrimidine biosynthesis (R-HSA-500753)
  G1/S-Specific Transcription (R-HSA-69205)
  E2F mediated regulation of DNA replication (R-HSA-113510)

Molecular Interaction Atlas (MIA) of This DTT

9 Approved Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capecitabine	DMTS85L	Colorectal cancer	2B91.Z	Approved	[2]
Ciprofloxacin XR	DM2NLS9	Bacterial infection	1A00-1C4Z	Approved	[3]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[4]
Flucytosine	DM13VTW	Endocarditis	BB40-BA42	Approved	[5]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[6], [7], [8], [9]
Leucovorin/5-fluorouracil	DMZT4N7	Colon cancer	2B90.Z	Approved	[10], [11]
Pemetrexed	DMMX2E6	Malignant pleural mesothelioma	2C26.0	Approved	[1]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[12], [13]
Trifluridine	DMG2YBD	Virus infection	1A24-1D9Z	Approved	[14]

6 Clinical Trial Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nolatrexed	DMOF0CA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[15]
Plevitrexed	DM7Y60I	Gastric adenocarcinoma	2B72	Phase 2	[16]
Plevitrexed (R)-isomer	DMTL39C	Gastric adenocarcinoma	2B72	Phase 2	[16]
UFT/leucovorin calcium	DMWDJ15	Colorectal cancer	2B91.Z	Phase 2	[17]
NB1011	DM5O4GR	Breast cancer	2C60-2C65	Phase 1/2	[18]
DFP-11207	DMY6QFH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]

7 Discontinued Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EMITEFUR	DMKQI7S	Solid tumour/cancer	2A00-2F9Z	Discontinued in Preregistration	[20]
Galocitabine	DMNSE2I	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 3	[21]
FO-152	DM3PXLZ	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[22]
TT-62	DMWXOJN	Virus infection	1A24-1D9Z	Discontinued in Phase 2	[23]
AG-331	DMCEM0L	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[24]
DMPDDF	DMLBS83	Solid tumour/cancer	2A00-2F9Z	Terminated	[25]
Fosfluridine tidoxil	DMSYLIF	Keratosis	ED56	Terminated	[26]

33 Investigative Drug(s) Targeting This DTT

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(6s)-5,6,7,8-Tetrahydrofolate	DMRAC6T	Discovery agent	N.A.	Investigative	[27]
1,3-propanediphosphonic acid	DMVBI2C	Discovery agent	N.A.	Investigative	[28]
1,4-Dithiothreitol	DMIFOXE	Discovery agent	N.A.	Investigative	[27]
10-Propargyl-5,8-Dideazafolic Acid	DMR3A5N	N. A.	N. A.	Investigative	[27]
2'-5'dideoxyuridine	DM6P3Z8	Discovery agent	N.A.	Investigative	[29]
2'-Deoxycytidine-5'-Monophosphate	DMG7CAU	Discovery agent	N.A.	Investigative	[27]
2'-Deoxyguanosine-5'-Monophosphate	DMY9FDT	Discovery agent	N.A.	Investigative	[27]
2'-Deoxyuridine	DM1HMWA	Discovery agent	N.A.	Investigative	[27]
2'-deoxyuridylic acid	DMPV1LU	Discovery agent	N.A.	Investigative	[27]
2-bromophenol	DM6JDIY	Discovery agent	N.A.	Investigative	[29]
2-Sulfhydryl-Ethanol	DMJBO3D	Discovery agent	N.A.	Investigative	[27]
3-Amino-5,6-dihydro-2H-benzo[f]quinazolin-1-one	DMP2K1A	Discovery agent	N.A.	Investigative	[30]
3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE	DMVHQB8	Discovery agent	N.A.	Investigative	[31]
3-Methyl-2H-benzo[f]quinazolin-1-one	DMFC0H5	Discovery agent	N.A.	Investigative	[30]
4-CHLORO-3',3''-DIBROMOPHENOL-1,8-NAPHTHALEIN	DMIYVJX	Discovery agent	N.A.	Investigative	[29]
5,10-Methylene-6-Hydrofolic Acid	DMAQDK9	Discovery agent	N.A.	Investigative	[27]
5-Fluoro-2'-Deoxyuridine-5'-Monophosphate	DME1AGO	Discovery agent	N.A.	Investigative	[27]
6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE	DM9OD7U	Discovery agent	N.A.	Investigative	[31]
Ly231514 Tetra Glu	DM5VWCI	Discovery agent	N.A.	Investigative	[27]
LY341770	DMS7KW8	Discovery agent	N.A.	Investigative	[27]
Methionine Sulfoxide	DMKE18W	Discovery agent	N.A.	Investigative	[31]
N,O-Didansyl-L-Tyrosine	DM7FT8D	Discovery agent	N.A.	Investigative	[27]
N-Carboxymethionine	DMX80JF	Discovery agent	N.A.	Investigative	[27]
N-[Tosyl-D-Prolinyl]Amino-Ethanethiol	DMN493F	Discovery agent	N.A.	Investigative	[27]
OVI-117	DMAV9PS	Solid tumour/cancer	2A00-2F9Z	Investigative	[22]
PREMETREXED	DMVOGT4	Discovery agent	N.A.	Investigative	[32]
S,S-(2-Hydroxyethyl)Thiocysteine	DMLPAD8	Discovery agent	N.A.	Investigative	[27]
Sp-722	DMV1W4M	Discovery agent	N.A.	Investigative	[27]
Sp-876	DMJZKEH	Discovery agent	N.A.	Investigative	[27]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[27]
Tosyl-D-Proline	DMNC2A5	Discovery agent	N.A.	Investigative	[27]
Uridine-5'-Monophosphate	DMG1NM7	Discovery agent	N.A.	Investigative	[27]
ZD1604	DMLI8GZ	Discovery agent	N.A.	Investigative	[9]

References

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