Details of the Drug | DrugMAP

General Information of Drug (ID: DMCIAJL)

Drug Name	N-hydroxy-nor-L-arginine
Structure
Structure	3D MOL			2D MOL
#Ro5 Violations (Lipinski): 1	Molecular Weight (mw)			176.17
	Logarithm of the Partition Coefficient (xlogp)			-4.6
	Rotatable Bond Count (rotbonds)			5
	Hydrogen Bond Donor Count (hbonddonor)			5
	Hydrogen Bond Acceptor Count (hbondacc)			5
Chemical Identifiers	Formula C5H12N4O3 IUPAC Name (2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid Canonical SMILES C(CN=C(N)NO)[C@@H](C(=O)O)N InChI InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-8-5(7)9-12/h3,12H,1-2,6H2,(H,10,11)(H3,7,8,9)/t3-/m0/s1 InChIKey KOBHCUDVWOTEKO-VKHMYHEASA-N
Cross-matching ID	PubChem CID 446124 CAS Number 189302-40-7 DrugBank ID DB02381 TTD ID D09ZIC

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kidney-type arginase (ARG2)	TTV1AG6	ARGI2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003 Oct 21;108(16):2000-6.