Details of the Drug

General Information of Drug (ID: DMCKNBA)

Drug Name

Lufironil

Synonyms

Hoe-077

Indication

Disease Entry	ICD 11	Status	REF
Liver cirrhosis	DB93.1	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

281.31

Logarithm of the Partition Coefficient (xlogp)

-0.6

Rotatable Bond Count (rotbonds)

8

Hydrogen Bond Donor Count (hbonddonor)

2

Hydrogen Bond Acceptor Count (hbondacc)

5

Chemical Identifiers

Formula: C13H19N3O4
IUPAC Name: 2-N,4-N-bis(2-methoxyethyl)pyridine-2,4-dicarboxamide
Canonical SMILES: COCCNC(=O)C1=CC(=NC=C1)C(=O)NCCOC
InChI: InChI=1S/C13H19N3O4/c1-19-7-5-15-12(17)10-3-4-14-11(9-10)13(18)16-6-8-20-2/h3-4,9H,5-8H2,1-2H3,(H,15,17)(H,16,18)
InChIKey: JUCNGMPTCXPMNB-UHFFFAOYSA-N

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prolyl 4-hydroxylasesubunit alpha-1 (P4HA1)	TTNH25W	P4HA1_HUMAN	Modulator	[1]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Interference in clinical laboratory tests, with special regard to the bilirubin assay: effects of a metabolite of the new prolyl 4-hydroxylase inhibitor, Lufironil. Eur J Clin Chem Clin Biochem. 1994Jul;32(7):515-20.