General Information of Disease (ID: DIS4G1GX)

Disease Name Liver cirrhosis
Synonyms liver cirrhosis; cirrhosis; cirrhosis of liver
Disease Class DB93: Hepatic fibrosis/cirrhosis
Definition
A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.
Disease Hierarchy
DIS2OMMF: Liver disease
DIS4G1GX: Liver cirrhosis
ICD Code
ICD-11
ICD-11: DB93.1
Expand ICD-11
'DB93.1
Disease Identifiers
MONDO ID
MONDO_0005155
MESH ID
D008103
UMLS CUI
C0023890
MedGen ID
7368
HPO ID
HP:0001394
SNOMED CT ID
19943007

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dexamethasone DMMWZET Approved Small molecular drug [1]
Peginterferon alfa-2b DMAP58Y Approved NA [2]
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This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Cellgram DMCD1PH Phase 3 Cell therapy [3]
Emricasan DMDCCPC Phase 2 Small molecular drug [4]
Lufironil DMCKNBA Phase 2 Small molecular drug [5]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AMT-070 DM8QZNX Terminated NA [6]
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This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Human liver progenitor cells DMJEBHQ Investigative NA [7]
STNM-04 DMJ81W4 Investigative NA [7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 220 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
DNMT3B TT6VZ78 Limited Altered Expression [8]
EGR1 TTE8LGD Limited Biomarker [9]
FGF2 TTGKIED Limited Altered Expression [10]
FOXC2 TTLBAP1 Limited Altered Expression [11]
IGF2R TTPNE41 Limited Altered Expression [12]
KLKB1 TTN0PCX Limited Biomarker [13]
NR1H4 TTS4UGC Limited Therapeutic [14]
PDGFD TTSN0GA Limited Biomarker [15]
RGS2 TTKB7T3 Limited Biomarker [16]
SPP1 TT8ME6I Limited Altered Expression [17]
TDGF1 TTN7HMG Limited Altered Expression [18]
TLR4 TTISGCA Limited Biomarker [19]
VSIR TT51SK8 Limited Altered Expression [20]
APOB TTN1IE2 moderate Genetic Variation [21]
AQP1 TTSF1KH moderate Altered Expression [22]
BMP7 TTKOBRA moderate Biomarker [23]
CR1 TTEA8OW moderate Genetic Variation [24]
CYBB TT5T8MR moderate Altered Expression [25]
CYP2D6 TTVG215 moderate Genetic Variation [26]
EDNRB TT3ZTGU moderate Biomarker [27]
GCG TT6Y4PN moderate Altered Expression [28]
GEM TTAZF9M moderate Genetic Variation [29]
GHR TTHJWYD moderate Posttranslational Modification [30]
KRT19 TT3JF9E moderate Biomarker [31]
MMP13 TTHY57M moderate Biomarker [32]
MMP7 TTMTWOS moderate Genetic Variation [33]
MMP8 TTGA1IV moderate Genetic Variation [34]
MSTN TTM8I2X moderate Altered Expression [35]
THBD TTAPV67 moderate Biomarker [36]
XRCC5 TTCB9KW moderate Biomarker [37]
ADAMTS13 TTUREBK Strong Biomarker [38]
ADRA1A TTNGILX Strong Biomarker [39]
ADRB2 TTG8ZWP Strong Genetic Variation [40]
ADRB3 TTMXGCW Strong Altered Expression [41]
AGRP TT4DE1O Strong Biomarker [42]
AGT TT5C0UB Strong Biomarker [43]
AHR TT037IE Strong Biomarker [44]
ALAD TTJHKYD Strong Biomarker [45]
ALB TTFNGC9 Strong Biomarker [46]
ALDH2 TTFLN4T Strong Biomarker [47]
ALPI TTHYMUV Strong Biomarker [48]
AOC3 TT7HC21 Strong Biomarker [49]
AOX1 TT3MOS2 Strong Altered Expression [50]
APOH TT2OUI9 Strong Altered Expression [51]
ARRB1 TTMVD4A Strong Biomarker [52]
ARRB2 TT8SO2I Strong Altered Expression [53]
ATIC TT9NVXQ Strong Biomarker [54]
ATP7B TTOPO51 Strong Biomarker [55]
ATXN3 TT6A17J Strong Genetic Variation [56]
AVP TTJ8EWH Strong Biomarker [57]
AZGP1 TTUPYLV Strong Altered Expression [58]
BIRC7 TTHZ8TA Strong Altered Expression [59]
BLVRA TTJBPN3 Strong Biomarker [60]
BMP1 TT0L58T Strong Biomarker [61]
BPI TTXCSDR Strong Biomarker [62]
C1QB TT8A9DM Strong Biomarker [52]
CASP1 TTCQIBE Strong Biomarker [63]
CCL2 TTNAY0P Strong Biomarker [64]
CCN2 TTIL516 Strong Biomarker [52]
CD9 TTZEIBV Strong Biomarker [52]
CFB TTA0P7K Strong Biomarker [65]
CHRM3 TTQ13Z5 Strong Biomarker [66]
CNR1 TT6OEDT Strong Biomarker [67]
CNR2 TTMSFAW Strong Altered Expression [68]
COL1A2 TTUABC1 Strong Biomarker [52]
COPS5 TTSTNJR Strong Altered Expression [69]
CPB1 TT4UJX5 Strong Biomarker [70]
CRP TTWRN6M Strong Altered Expression [71]
CXCL10 TTQOVYA Strong Altered Expression [72]
CXCL11 TTWG0RE Strong Biomarker [73]
CYP1A2 TTS1DTU Strong Biomarker [74]
CYP2A6 TTAQ6ZW Strong Altered Expression [75]
CYP2C19 TTZ58XG Strong Biomarker [76]
CYTH2 TTOM97J Strong Biomarker [60]
DNMT1 TT6S2FE Strong Biomarker [77]
EDN1 TTJR60Z Strong Biomarker [78]
EGF TTED8JB Strong Genetic Variation [79]
ENPP2 TTSCIM2 Strong Altered Expression [80]
F2R TTL935N Strong Biomarker [81]
F3 TT38MDJ Strong Altered Expression [82]
F5 TT1O264 Strong Biomarker [83]
F8 TT1290U Strong Altered Expression [84]
FDFT1 TTFQEO5 Strong Genetic Variation [85]
FGF19 TTGCH11 Strong Biomarker [86]
FGF21 TTQ916P Strong Altered Expression [87]
FGF7 TTFY134 Strong Altered Expression [88]
FGFR2 TTGJVQM Strong Biomarker [89]
FLT1 TT1VAUK Strong Biomarker [90]
GCK TTDLNGZ Strong Biomarker [91]
GHRL TT1OCL0 Strong Genetic Variation [92]
GIP TT40HS5 Strong Biomarker [93]
GLUL TTURQ2G Strong Biomarker [94]
GMNN TT390KA Strong Biomarker [95]
GNRH1 TT0ID4A Strong Biomarker [96]
GP6 TTTJUVZ Strong Altered Expression [97]
GPC3 TTJTSX4 Strong Biomarker [98]
GPNMB TT7315J Strong Altered Expression [99]
GRB2 TTEYRJ9 Strong Genetic Variation [100]
GRIN2A TTKJEMQ Strong Altered Expression [101]
GSTA1 TT4P8DE Strong Biomarker [25]
GSTO1 TTWO3SH Strong Biomarker [102]
GSTP1 TT40K12 Strong Genetic Variation [103]
HAMP TTRV5YJ Strong Biomarker [104]
HDAC2 TTSHTOI Strong Biomarker [105]
HEXB TTKIBKM Strong Biomarker [106]
HGF TT4V2JM Strong Biomarker [107]
HGFAC TTD96RW Strong Altered Expression [108]
HLA-DQA1 TTU2I3J Strong Genetic Variation [109]
HMBS TTT0HW3 Strong Altered Expression [110]
HMGCS2 TTS0EZJ Strong Altered Expression [111]
HPD TT8DSFC Strong Biomarker [112]
HSD11B2 TT9H85R Strong Biomarker [113]
HSPA8 TTMQL3K Strong Genetic Variation [114]
HTR7 TTO9X1H Strong Biomarker [115]
IFNAR2 TTMQB37 Strong Biomarker [116]
IFNL3 TTRF4Q2 Strong Genetic Variation [117]
IGFBP2 TTU4QSN Strong Biomarker [52]
IL6 TTT1V78 Strong Biomarker [118]
ITK TT3C80U Strong Biomarker [119]
KCNJ5 TTEO25X Strong Biomarker [120]
KIF11 TTBGTCW Strong Altered Expression [121]
KLK4 TT4319X Strong Genetic Variation [122]
LAIR1 TTSI7A8 Strong Biomarker [123]
LALBA TTBRLU3 Strong Biomarker [124]
LAMC2 TTNS7H3 Strong Biomarker [52]
LBP TTVQJLY Strong Genetic Variation [125]
LCN2 TTKTLAI Strong Biomarker [126]
LGALS1 TTO3NYT Strong Biomarker [52]
LIPA TTS8T1M Strong Genetic Variation [127]
LOX TTQHNAM Strong Biomarker [52]
MANF TT56RYE Strong Altered Expression [128]
MARCKS TTHRM39 Strong Posttranslational Modification [129]
MAT2A TTSMPXQ Strong Biomarker [130]
MMP1 TTMX39J Strong Biomarker [107]
MMP2 TTLM12X Strong Biomarker [107]
MUC16 TTC1PS3 Strong Altered Expression [131]
NAAA TTMN4HY Strong Biomarker [132]
NAGLU TTDM6HZ Strong Biomarker [133]
NFE2L2 TTA6ZN2 Strong Biomarker [134]
NOD2 TTYPUHA Strong Genetic Variation [135]
NOS3 TTCM4B3 Strong Biomarker [136]
NQO1 TT8XK6L Strong Therapeutic [137]
NR3C2 TT26PHO Strong Biomarker [138]
NUF2 TTIXBFP Strong Biomarker [139]
OPRD1 TT27RFC Strong Biomarker [140]
PDE1B TT3ZS42 Strong Biomarker [141]
PDGFB TTQA6SX Strong Biomarker [142]
PEMT TT735V2 Strong Biomarker [143]
PHKG2 TTI5WS6 Strong Genetic Variation [144]
PINX1 TT4FJ3A Strong Genetic Variation [145]
PLA2G2A TTO8QRU Strong Altered Expression [146]
PLAU TTGY7WI Strong Biomarker [52]
PLOD2 TT8MEUD Strong Biomarker [52]
PPP2CA TTHTKNY Strong Altered Expression [147]
PRLR TTBPXMA Strong Altered Expression [148]
PROC TTZUXYS Strong Biomarker [149]
PSMD10 TT2H4LN Strong Biomarker [150]
PTEN TTXJ3W7 Strong Biomarker [151]
PTN TTA9EJK Strong Altered Expression [152]
REN TTB2MXP Strong Biomarker [153]
RNF7 TTODWGT Strong Genetic Variation [154]
RTN4 TT7GXMU Strong Biomarker [155]
SAA1 TTY0DN9 Strong Biomarker [156]
SERPINA6 TTJL8VG Strong Biomarker [45]
SERPINB3 TT6QLPX Strong Altered Expression [157]
SERPINC1 TT4QPUL Strong Biomarker [158]
SERPING1 TTVQ6R9 Strong Biomarker [159]
SERPINH1 TTPSWQG Strong Biomarker [160]
SLC10A1 TTWZRY5 Strong Genetic Variation [161]
SLC22A8 TTTQR47 Strong Biomarker [45]
SLC25A1 TTTD730 Strong Genetic Variation [162]
SMAD3 TTHQZV7 Strong Biomarker [163]
SMN1 TT8QL6X Strong Altered Expression [164]
SNCG TT5TQNZ Strong Altered Expression [165]
SPARC TTBQFM7 Strong Biomarker [166]
SPRY1 TT0PSN6 Strong Altered Expression [167]
SPTBN1 TTS9BDA Strong Biomarker [168]
SSTR2 TTZ6T9E Strong Altered Expression [169]
ST8SIA4 TTDP8YM Strong Biomarker [170]
STAT1 TTN7R6K Strong Therapeutic [171]
TAGLN2 TTP6BIJ Strong Biomarker [45]
TAP1 TT7JZI8 Strong Genetic Variation [172]
TEP1 TTQGAVX Strong Genetic Variation [145]
TGFBR1 TTP4520 Strong Biomarker [173]
THBS1 TTKI0H1 Strong Genetic Variation [174]
TLR2 TTY7ZHS Strong Altered Expression [175]
TLR3 TTD24Y0 Strong Biomarker [19]
TLR7 TTRJ1K4 Strong Biomarker [176]
TM6SF2 TTE1OHM Strong Genetic Variation [177]
TNFAIP3 TT5W0IO Strong Genetic Variation [178]
TNFRSF1B TT63WSF Strong Biomarker [179]
TNFSF13B TTWMIDN Strong Altered Expression [180]
TRH TT2Z39D Strong Biomarker [96]
TRPM5 TT1N8F3 Strong Genetic Variation [181]
TRPM7 TTFPVZO Strong Biomarker [182]
TRPV2 TTBECWA Strong Altered Expression [183]
UTS2R TTW5UDX Strong Biomarker [184]
VEGFA TT3LJ9K Strong Biomarker [185]
VIPR1 TTCL30I Strong Biomarker [186]
VWF TT3SZBT Strong Biomarker [187]
ZWINT TTWY768 Strong Altered Expression [188]
BAGE TTS5GLJ Definitive Altered Expression [189]
CPE TTXPWO6 Definitive Biomarker [190]
CXCL9 TTWE5PB Definitive Biomarker [191]
DCLK1 TTOHTCY Definitive Altered Expression [192]
DCN TTB3XAN Definitive Biomarker [193]
DDX5 TTZKPVC Definitive Genetic Variation [194]
FGFR4 TT1KX2S Definitive Genetic Variation [195]
GLO1 TTV9A7R Definitive Altered Expression [196]
HTR2A TTJQOD7 Definitive Biomarker [197]
IFNAR1 TTSYFMA Definitive Altered Expression [116]
IRF3 TTYR7OH Definitive Genetic Variation [198]
LYVE1 TTG8DNU Definitive Biomarker [199]
MFGE8 TT1GLAJ Definitive Biomarker [200]
NAMPT TTD1WIG Definitive Genetic Variation [201]
OTC TT5KIO9 Definitive Biomarker [202]
PDE5A TTJ0IQB Definitive Biomarker [203]
PRMT1 TTVOJAI Definitive Altered Expression [204]
SELP TTE5VG0 Definitive Biomarker [205]
SYVN1 TT8XKYM Definitive Biomarker [206]
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⏷ Show the Full List of 220 DTT(s)
This Disease Is Related to 9 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCB5 DTKVEXO Strong Altered Expression [207]
ABCD1 DTKM9DZ Strong Genetic Variation [208]
SLC11A1 DT650XW Strong Genetic Variation [209]
SLC13A4 DTJZ7W2 Strong Biomarker [45]
SLC17A2 DTRF4L3 Strong Biomarker [45]
SLC26A3 DTN1FMD Strong Genetic Variation [210]
SLC27A5 DT0TQS3 Strong Altered Expression [211]
SLC30A10 DTYBI73 Strong Biomarker [212]
SLC4A1 DTB0Q3P Strong Biomarker [213]
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⏷ Show the Full List of 9 DTP(s)
This Disease Is Related to 22 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
GCLC DESYL1F Limited Biomarker [214]
ADH1B DEEN9RD Strong Biomarker [215]
ADH1C DEM1HNL Strong Genetic Variation [216]
ADH5 DEIOH6A Strong Genetic Variation [217]
AKR1A1 DED2FW3 Strong Biomarker [57]
AKR1B10 DEP6GT1 Strong Biomarker [218]
CYP1A1 DE6OQ3W Strong Genetic Variation [219]
CYP27A1 DEBS639 Strong Biomarker [220]
CYP2R1 DEBIHM3 Strong Biomarker [220]
CYP3A7 DERD86B Strong Altered Expression [221]
CYP4A11 DE2XQGW Strong Altered Expression [221]
CYP4F3 DEFCMPI Strong Biomarker [222]
DHCR7 DEL7GFA Strong Biomarker [220]
GLS DE3E0VT Strong Genetic Variation [223]
MAT1A DEQ6NC9 Strong Posttranslational Modification [224]
NAT10 DEZV4AP Strong Altered Expression [225]
NT5C2 DE1DOKJ Strong Biomarker [226]
P4HA2 DE5EGK0 Strong Biomarker [227]
TPMT DEFQ8VO Strong Biomarker [228]
DDAH1 DEY0TQC Definitive Altered Expression [14]
MMEL1 DEYCUQ2 Definitive Genetic Variation [229]
UGT1A7 DEZO4N3 Definitive Genetic Variation [230]
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⏷ Show the Full List of 22 DME(s)
This Disease Is Related to 306 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
AKAP12 OTCVRDDX Limited Biomarker [231]
CBLL2 OTB4AD3V Limited Biomarker [232]
DCD OTV5PBGJ Limited Altered Expression [233]
DNAJB11 OTDDK2SY Limited Altered Expression [234]
KRT18 OTVLQFIP Limited Altered Expression [235]
MUC2 OT3X4QVX Limited Biomarker [236]
MUL1 OT2JC9YR Limited Biomarker [232]
NANS OTMQ2FUH Limited Genetic Variation [237]
RAB27A OT9SQRWY Limited Altered Expression [238]
RAD50 OTYMU9G1 Limited Therapeutic [239]
SELENOP OT02B8IR Limited Biomarker [240]
TSPAN31 OT8WQ83R Limited Genetic Variation [237]
TMEM67 OTME92T5 Disputed Biomarker [241]
AQP2 OTQLBKK6 moderate Altered Expression [242]
CKS2 OTPTMHIV moderate Altered Expression [243]
DCTN6 OTI8PIN9 moderate Biomarker [244]
FAH OTGZA1YR moderate Biomarker [245]
FUT1 OTODG57A moderate Biomarker [244]
GFER OTVK43OK moderate Altered Expression [246]
HAVCR2 OTOL603T moderate Altered Expression [247]
IFI27 OTI2XGIT moderate Biomarker [244]
KIR3DL1 OTPOSXFX moderate Genetic Variation [29]
MST1 OTOC4UNG moderate Biomarker [248]
PAXIP1 OTRHTKG3 moderate Altered Expression [249]
PSMD9 OT6Y5CC3 moderate Biomarker [244]
QSOX1 OT4ZPK4P moderate Biomarker [250]
RARRES2 OT1BJE8K moderate Altered Expression [251]
SHBG OTPWU5IW moderate Altered Expression [252]
SPINK1 OTSUVAL2 moderate Altered Expression [253]
TICAM2 OTK7GIJ5 moderate Biomarker [244]
TMED7 OTONO8E6 moderate Biomarker [244]
TRIO OT71X1AK moderate Biomarker [254]
A2M OTFTX90K Strong Biomarker [52]
AADAC OT8VACT2 Strong Biomarker [255]
ACTA2 OTEDLG8E Strong Biomarker [256]
ACYP2 OTRB4S6X Strong Genetic Variation [257]
ADAM12 OTZKOTDB Strong Altered Expression [258]
ADARB1 OTGKSZEV Strong Altered Expression [259]
ADGRF1 OTRAOBYH Strong Biomarker [260]
ADRM1 OTOU4EY6 Strong Genetic Variation [122]
AFM OTPOR8IO Strong Biomarker [261]
AGA OTNWT1WB Strong Biomarker [262]
AKAP13 OTOZAR14 Strong Biomarker [263]
ALDOB OT7FR69A Strong Biomarker [264]
ALLC OTZE4XV7 Strong Biomarker [265]
ALPP OTZU4G9W Strong Biomarker [48]
ANKS6 OT6DXD3Q Strong Biomarker [266]
ARHGEF1 OTXU4HBW Strong Altered Expression [267]
ARID4B OTYLPILE Strong Biomarker [268]
ARNT OTMSIEZY Strong Biomarker [269]
ARSH OTG0X9UQ Strong Genetic Variation [100]
ARTN OTWIWGL6 Strong Biomarker [42]
ASPM OTKXQMNA Strong Altered Expression [270]
ATP8B1 OTALGS63 Strong Biomarker [271]
ATRNL1 OTY5JUX2 Strong Altered Expression [225]
AZIN1 OTX5W77I Strong Genetic Variation [181]
AZIN2 OT8OB7CG Strong Biomarker [272]
AZU1 OTHXU264 Strong Biomarker [273]
BAMBI OTCEJ8W5 Strong Biomarker [256]
BCL2L12 OTS6IFZY Strong Genetic Variation [198]
BCL6B OT1T5KM6 Strong Altered Expression [274]
BOC OTXBCY9W Strong Genetic Variation [275]
BTBD8 OT3A3RD7 Strong Biomarker [276]
CABIN1 OT4G5CIK Strong Biomarker [277]
CALCOCO2 OTRGX0OV Strong Genetic Variation [278]
CAVIN1 OTFO915U Strong Biomarker [279]
CAVIN2 OTFHHDRU Strong Altered Expression [280]
CAVIN3 OTOLBK79 Strong Altered Expression [279]
CCL14 OT8QETQU Strong Biomarker [281]
CCL28 OTY6XNQ7 Strong Biomarker [282]
CCL4 OT6B8P25 Strong Biomarker [283]
CCL4L2 OTDBSXOU Strong Biomarker [284]
CCN3 OTOW5YL4 Strong Biomarker [164]
CCNA1 OTX4HD45 Strong Genetic Variation [285]
CD1D OT3ROU4J Strong Biomarker [286]
CD244 OTSMR85N Strong Genetic Variation [287]
CD5L OTPY4WQR Strong Biomarker [288]
CD63 OT2UGZA9 Strong Biomarker [289]
CDK2AP2 OTR99SJ8 Strong Genetic Variation [290]
CDO1 OTLG1P77 Strong Posttranslational Modification [291]
CEACAM8 OTLL9WWO Strong Biomarker [289]
CFHR1 OT72R16T Strong Altered Expression [292]
CHI3L1 OT2Z7VJH Strong Biomarker [293]
CIR1 OTKP5JKH Strong Biomarker [120]
CKS1B OTNUPLUJ Strong Altered Expression [294]
CLNK OTOWK51S Strong Genetic Variation [295]
CLTC OTBFASMA Strong Biomarker [213]
COL13A1 OTM9IM6J Strong Genetic Variation [85]
COL1A1 OTI31178 Strong Genetic Variation [296]
COL3A1 OTT1EMLM Strong Genetic Variation [297]
COL5A2 OT5VOSQE Strong Biomarker [52]
COMMD1 OT7WUD5R Strong Biomarker [298]
COX8A OTU0NR39 Strong Biomarker [299]
CP OTM8JE4Y Strong Biomarker [159]
CPT1A OTI862QH Strong Genetic Variation [300]
CRACR2A OTJUGSVE Strong Genetic Variation [85]
CSN3 OTR61MI8 Strong Altered Expression [301]
CST3 OTNZ6AO4 Strong Biomarker [133]
CTHRC1 OTV88X2G Strong Altered Expression [302]
CYBA OT16N9ZO Strong Biomarker [45]
CYBRD1 OTUTVBES Strong Biomarker [303]
CYGB OTX153DQ Strong Biomarker [304]
DBP OTE0W7LN Strong Biomarker [305]
DDX60L OTB5ZY3C Strong Genetic Variation [85]
DENND4A OT8FFZ29 Strong Altered Expression [306]
DERL2 OTI3TUUZ Strong Biomarker [307]
DGKB OTTT9SZJ Strong Genetic Variation [308]
DGKE OTWS86AS Strong Genetic Variation [308]
DGUOK OT78HUZB Strong Genetic Variation [308]
DLAT OT9LBJVN Strong Biomarker [309]
DMBT1 OTVNU9D9 Strong Altered Expression [310]
EHBP1L1 OTZMO30X Strong Genetic Variation [85]
EIF1 OTB4GZ0V Strong Altered Expression [311]
EIF2S1 OTM0GDTP Strong Genetic Variation [312]
EIF2S2 OTXF0B09 Strong Genetic Variation [312]
EIF2S3 OTARRES9 Strong Genetic Variation [312]
ELN OTFSO7PG Strong Biomarker [313]
ENAM OTK8PU0T Strong Biomarker [314]
ENHO OT91QASK Strong Biomarker [261]
ESM1 OT331Y8V Strong Altered Expression [315]
ETV3 OTEN03BM Strong Biomarker [316]
EVL OTZ8ZDNY Strong Biomarker [317]
FAM13A OTZ6GN0Q Strong Altered Expression [318]
FBL OTRODIE5 Strong Genetic Variation [319]
FBN1 OTYCJT63 Strong Biomarker [52]
FCN1 OTK6ZHXH Strong Biomarker [320]
FCN2 OTTHJBKZ Strong Biomarker [321]
FDX1 OT7I3DN0 Strong Biomarker [322]
FIBP OTI7131S Strong Altered Expression [323]
FMOD OT9EJ5H8 Strong Altered Expression [324]
GADL1 OTJM4A0R Strong Biomarker [272]
GALT OTCATU66 Strong Genetic Variation [325]
GC OTWS63BY Strong Biomarker [326]
GCDH OTVQMZZN Strong Biomarker [327]
GGPS1 OTVEHG28 Strong Biomarker [328]
GGTLC1 OTWJKUHQ Strong Biomarker [329]
GLT8D2 OT4VS9YY Strong Genetic Variation [330]
GNB3 OTA6HYBA Strong Genetic Variation [331]
GOLPH3 OTDLGYM3 Strong Biomarker [332]
GPAA1 OTWVRR35 Strong Altered Expression [333]
GPT2 OTS5VF7N Strong Biomarker [334]
GSPT2 OTN0K7F3 Strong Biomarker [335]
HABP2 OTAUIPW0 Strong Genetic Variation [336]
HARS1 OTHOEOTS Strong Genetic Variation [337]
HDLBP OTKDEEYX Strong Altered Expression [338]
HEPH OTZ2F15Z Strong Biomarker [303]
HERPUD1 OT9EROL6 Strong Genetic Variation [339]
HES6 OTWO5SCF Strong Altered Expression [340]
HGS OTCYYCAC Strong Genetic Variation [337]
HK3 OTZKONGB Strong Biomarker [91]
HLA-DRB3 OT5PM9N7 Strong Genetic Variation [341]
HMGB3 OTCJ2EZY Strong Biomarker [342]
HPX OT14T7Q1 Strong Altered Expression [159]
HSF4 OT1UX9SK Strong Biomarker [343]
HSPA12A OTFOCDD6 Strong Biomarker [344]
HTRA2 OTC7616F Strong Altered Expression [345]
IFITM3 OT2QP8D3 Strong Genetic Variation [346]
IGF2BP2 OT4ZSEEE Strong Altered Expression [347]
IL10RA OTOX3D1D Strong Genetic Variation [348]
IMMP2L OT9WGAFD Strong Altered Expression [347]
IRF7 OTC1A2PQ Strong Genetic Variation [349]
ITPA OTQ47WVR Strong Genetic Variation [350]
JCHAIN OTR8M5TX Strong Altered Expression [159]
JPT1 OT6CRZEU Strong Genetic Variation [122]
JUND OTNKACJD Strong Biomarker [351]
KIR2DS4 OT00N6UJ Strong Biomarker [352]
KLF10 OT4F4UGS Strong Altered Expression [353]
KLF9 OTBFEJRQ Strong Altered Expression [353]
KLHL1 OTAX6SAD Strong Altered Expression [354]
KLK10 OTD573EL Strong Posttranslational Modification [355]
LAMTOR2 OTHEDISB Strong Genetic Variation [290]
LGALS3BP OT9AGQKH Strong Biomarker [356]
LHX2 OTK61NP8 Strong Altered Expression [357]
LMNB1 OT100T3P Strong Biomarker [37]
LOXL1 OTA0NEJU Strong Altered Expression [313]
LUM OTSRC874 Strong Altered Expression [159]
MACC1 OTV3DLX0 Strong Altered Expression [358]
MACROH2A1 OTV2DQDD Strong Altered Expression [359]
MAGT1 OTQSAV5C Strong Biomarker [48]
MAK16 OTD546E5 Strong Altered Expression [360]
MARCHF2 OTADQ0OA Strong Biomarker [361]
MARCHF6 OTBTA03N Strong Biomarker [362]
MARCHF8 OTH7PNN2 Strong Biomarker [363]
MATN2 OTVDR68G Strong Altered Expression [364]
MAVS OTTQ0J64 Strong Biomarker [365]
MBOAT7 OTHRCBLK Strong Genetic Variation [366]
MCC OTQVI1EM Strong Biomarker [367]
MCF2L2 OTOGFMIH Strong Biomarker [368]
MCM2 OTGGORIQ Strong Biomarker [95]
MEF2A OTV2SF6E Strong Altered Expression [369]
MLN OTBZ5SE5 Strong Altered Expression [370]
MLXIP OT30UNI7 Strong Biomarker [363]
MMRN1 OT7ZNYHT Strong Biomarker [371]
MPV17 OT579DMU Strong Genetic Variation [372]
MSMP OT20VCWP Strong Altered Expression [373]
MSX2 OT1WDKE1 Strong Altered Expression [357]
MTFMT OT1OIVJL Strong Biomarker [374]
MYLIP OTL0PFGV Strong Biomarker [363]
NANOS1 OT3UNZZY Strong Genetic Variation [136]
NANOS3 OTGX9IQU Strong Biomarker [136]
NBAS OTW9IBRI Strong Biomarker [133]
NCOA6 OTOMIGTV Strong Genetic Variation [375]
NDST1 OT9E10W2 Strong Altered Expression [376]
NENF OTGL7MHB Strong Biomarker [377]
NFE2 OTLM94BI Strong Biomarker [378]
NOSTRIN OT0LDSGS Strong Altered Expression [379]
NOX1 OTZPJQCC Strong Altered Expression [380]
NPC1 OTRIPICX Strong Biomarker [381]
NPC2 OTE9UEJC Strong Biomarker [382]
NPPA OTMQNTNX Strong Biomarker [383]
NR1D2 OT9CVF41 Strong Biomarker [384]
NUDT15 OTX8SZOT Strong Biomarker [228]
NUMB OTMB586Q Strong Biomarker [385]
NUP210 OT3BLQ9M Strong Biomarker [386]
NUP62 OTMN63DH Strong Altered Expression [35]
OAS1 OT8ZLOCY Strong Genetic Variation [387]
OGA OT7ZBWT1 Strong Biomarker [388]
OR2AG1 OTEITRP4 Strong Genetic Variation [389]
OSCP1 OTZ4IFGJ Strong Altered Expression [390]
PAEP OTQA0NV4 Strong Biomarker [391]
PC OT6O0V51 Strong Genetic Variation [392]
PCOLCE OTJXOAN4 Strong Biomarker [52]
PDIA3 OTHPQ0Q3 Strong Biomarker [393]
PDLIM3 OTVXQC81 Strong Altered Expression [225]
PDSS2 OTEOQBMX Strong Altered Expression [394]
PHEX OTG7N3J7 Strong Genetic Variation [395]
PIAS3 OT3TWH9R Strong Altered Expression [396]
PIGR OT6GLSUL Strong Biomarker [264]
PIWIL2 OT1PXQIF Strong Biomarker [397]
PLA1A OT2IXYNX Strong Biomarker [398]
PNO1 OT010GIS Strong Altered Expression [360]
POTEF OTV3WXYE Strong Biomarker [399]
PPIP5K1 OT06HYH8 Strong Biomarker [365]
PPP1R13L OTNCPLWE Strong Altered Expression [400]
PRRX1 OTTZK5G8 Strong Biomarker [401]
PSMC5 OTJOORMR Strong Biomarker [378]
PTX3 OTPXHRKU Strong Altered Expression [402]
RAPGEF5 OT53VS75 Strong Biomarker [403]
RASGRF2 OT67DAGF Strong Genetic Variation [404]
RASSF1 OTEZIPB7 Strong Biomarker [405]
RBP1 OTRP1MFC Strong Altered Expression [406]
RETN OTW5Z1NH Strong Altered Expression [28]
RGN OTD04KB1 Strong Altered Expression [407]
RMC1 OT7K8MTJ Strong Altered Expression [408]
RNF187 OTXTN1HP Strong Altered Expression [409]
RNH1 OT6EC79B Strong Biomarker [410]
RPP14 OT4OYFSK Strong Genetic Variation [290]
RPS27A OTIIGGZ2 Strong Altered Expression [411]
RSC1A1 OT54EM29 Strong Biomarker [412]
RXFP2 OT7SAT9U Strong Biomarker [413]
SAA2 OTYAVJWG Strong Biomarker [156]
SARNP OTE0OVK5 Strong Biomarker [414]
SCAF1 OT16TM3N Strong Genetic Variation [198]
SCN7A OTK05PXY Strong Biomarker [133]
SF3B6 OTPRKS6S Strong Genetic Variation [290]
SFRP5 OTLCVVSH Strong Genetic Variation [415]
SFTPA1 OT87XL1U Strong Biomarker [416]
SFXN1 OTL66767 Strong Biomarker [417]
SH2B1 OTJZO2CI Strong Biomarker [418]
SH2D4A OTH562MY Strong Altered Expression [419]
SHARPIN OTU1J2KH Strong Biomarker [420]
SIGLEC1 OTNWSQA9 Strong Biomarker [421]
SMARCA2 OTSGJ8SV Strong Altered Expression [422]
SMARCA5 OT5GR4Z2 Strong Biomarker [423]
SMIM1 OTWSFC2F Strong Biomarker [424]
SMN2 OT54RLO1 Strong Altered Expression [164]
SMURF2 OT3TRVL7 Strong Biomarker [425]
SOX1 OTVI1RAR Strong Altered Expression [426]
SPINT1 OT1CLR5L Strong Biomarker [427]
SPPL3 OT2HLJF6 Strong Altered Expression [347]
SRRM2 OTSIMMC9 Strong Altered Expression [360]
SRSF3 OTOFT707 Strong Genetic Variation [428]
SRSF5 OTC5WP98 Strong Genetic Variation [337]
STEAP3 OTS9GZK5 Strong Altered Expression [429]
SULF1 OTJCNCO0 Strong Altered Expression [430]
SYCE1L OTXU44F3 Strong Altered Expression [354]
SYNM OTOI8TRJ Strong Biomarker [431]
TANK OTZSGFIK Strong Genetic Variation [432]
TAP2 OTWSYFI7 Strong Genetic Variation [433]
TENM3 OTWY13GR Strong Genetic Variation [434]
THBS4 OTA1T9KK Strong Altered Expression [435]
THEM6 OT51SVLH Strong Biomarker [436]
TMC4 OT8FX82D Strong Genetic Variation [437]
TMPRSS13 OTMAOAP3 Strong Biomarker [438]
TRIM63 OTUSWA74 Strong Altered Expression [439]
TRMU OTJ1KXM7 Strong Genetic Variation [440]
ADIPOR2 OT2HDTL8 Definitive Genetic Variation [441]
AXIN1 OTRGZGZ5 Definitive Genetic Variation [442]
BMPER OTBYON4H Definitive Biomarker [443]
CHPT1 OT4FJ0K3 Definitive Biomarker [444]
CLDN3 OT71MN9S Definitive Altered Expression [445]
CPEB4 OTW1SCZW Definitive Altered Expression [446]
DDX53 OTHK3EGZ Definitive Genetic Variation [447]
DEPDC5 OTE70JLY Definitive Genetic Variation [448]
DHDDS OTVLYBUS Definitive Biomarker [444]
GCA OTAJ7ZHG Definitive Genetic Variation [449]
GNMT OT0O2OQO Definitive Biomarker [450]
KLF2 OTIP1UFX Definitive Altered Expression [451]
MINDY4 OTBZ2SZB Definitive Genetic Variation [452]
PPIG OTZ8BTTM Definitive Genetic Variation [170]
PROX1 OT68R6IO Definitive Biomarker [453]
SFRP2 OT8GZ0CA Definitive Genetic Variation [454]
SPRY2 OTH0CRCZ Definitive Biomarker [455]
TALDO1 OTDKV2S2 Definitive Biomarker [456]
TFR2 OTMYCCEO Definitive Genetic Variation [457]
TNFAIP8L2 OTII0RM0 Definitive Altered Expression [458]
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⏷ Show the Full List of 306 DOT(s)

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74 The impact of serotonergic system dysfunction on the regulation of P4501A isoforms during liver insufficiency and consequences for thyroid hormone homeostasis.Food Chem Toxicol. 2016 Nov;97:70-81. doi: 10.1016/j.fct.2016.08.027. Epub 2016 Aug 24.
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77 The interaction between microRNA-152 and DNA methyltransferase-1 as an epigenetic prognostic biomarker in HCV-induced liver cirrhosis and HCC patients.Cancer Gene Ther. 2020 Jun;27(6):486-497. doi: 10.1038/s41417-019-0123-9. Epub 2019 Jul 18.
78 Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats.Can J Physiol Pharmacol. 2010 Jun;88(6):636-43. doi: 10.1139/Y10-038.
79 Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.Clin Transplant. 2016 Apr;30(4):452-60. doi: 10.1111/ctr.12710. Epub 2016 Mar 1.
80 Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C.J Clin Gastroenterol. 2007 Jul;41(6):616-23. doi: 10.1097/01.mcg.0000225642.90898.0e.
81 The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.Am J Pathol. 2010 Dec;177(6):2837-49. doi: 10.2353/ajpath.2010.100425. Epub 2010 Oct 29.
82 Non-neoplastic Portal Vein Thrombosis in HCV Cirrhosis Patients: Is it an Immuno-Inflammatory Disorder?.Ann Hepatol. 2017 Jul-Aug;16(4):574-583. doi: 10.5604/01.3001.0010.0296.
83 Coagulation status modulates murine hepatic fibrogenesis: implications for the development of novel therapies.J Thromb Haemost. 2008 Aug;6(8):1336-43. doi: 10.1111/j.1538-7836.2008.03015.x. Epub 2008 May 14.
84 Increased factor VIII plays a significant role in plasma hypercoagulability phenotype of patients with cirrhosis.J Thromb Haemost. 2018 Jun;16(6):1132-1140. doi: 10.1111/jth.14011. Epub 2018 May 17.
85 Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.Gastroenterology. 2010 Nov;139(5):1567-76, 1576.e1-6. doi: 10.1053/j.gastro.2010.07.057. Epub 2010 Aug 11.
86 Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis.Ann Agric Environ Med. 2017 Sep 21;24(3):544-548. doi: 10.26444/aaem/76937. Epub 2017 Sep 16.
87 Fibroblast growth factor 21 is an early predictor of acute-on-chronic liver failure in critically ill patients with cirrhosis.Liver Transpl. 2018 May;24(5):595-605. doi: 10.1002/lt.25041. Epub 2018 Apr 6.
88 Suppression of MicroRNA-219-5p Activates Keratinocyte Growth Factor to Mitigate Severity of Experimental Cirrhosis.Cell Physiol Biochem. 2016;40(1-2):253-262. doi: 10.1159/000452542. Epub 2016 Nov 18.
89 Identification of latent biomarkers in hepatocellular carcinoma by ultra-deep whole-transcriptome sequencing.Oncogene. 2014 Sep 25;33(39):4786-94. doi: 10.1038/onc.2013.424. Epub 2013 Oct 21.
90 Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis.Liver Int. 2007 Sep;27(7):960-8. doi: 10.1111/j.1478-3231.2007.01542.x.
91 Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis.Biochim Biophys Acta. 1998 Jan 8;1379(1):134-42. doi: 10.1016/s0304-4165(97)00092-5.
92 Association of Ghrelin Gene Polymorphisms and Serum Ghrelin Levels with the Risk of Hepatitis B Virus-Related Liver Diseases in a Chinese Population.PLoS One. 2015 Nov 23;10(11):e0143069. doi: 10.1371/journal.pone.0143069. eCollection 2015.
93 The role of incretin hormones and glucagon in patients with liver disease.Dan Med J. 2017 May;64(5):B5363.
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232 Identification of the inhibitory activity of walnut extract on the E3 ligase Syvn1.Mol Med Rep. 2018 Dec;18(6):5701-5708. doi: 10.3892/mmr.2018.9576. Epub 2018 Oct 23.
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238 HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.Cell Death Dis. 2018 May 1;9(5):513. doi: 10.1038/s41419-018-0534-9.
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296 Epigenetic Effects of an Adenosine Derivative in a Wistar Rat Model of Liver Cirrhosis.J Cell Biochem. 2018 Jan;119(1):401-413. doi: 10.1002/jcb.26192. Epub 2017 Jul 4.
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303 Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis.Hepatology. 2004 Feb;39(2):492-9. doi: 10.1002/hep.20038.
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305 Validation of non-invasive haemodynamic methods in patients with liver disease: the Finometer and the Task Force Monitor.Clin Physiol Funct Imaging. 2018 May;38(3):384-389. doi: 10.1111/cpf.12425. Epub 2017 Apr 12.
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307 Disparate Trends in Mortality of Etiology-Specific Chronic Liver Diseases Among Hispanic Subpopulations.Clin Gastroenterol Hepatol. 2019 Jul;17(8):1607-1615.e2. doi: 10.1016/j.cgh.2018.10.045. Epub 2018 Nov 1.
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317 Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis.Hepatology. 2017 Oct;66(4):1219-1231. doi: 10.1002/hep.29267. Epub 2017 Aug 26.
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319 Hepatitis C Virus (HCV) Treatment With Directly Acting Agents Reduces the Risk of Incident Diabetes: Results From Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES).Clin Infect Dis. 2020 Mar 3;70(6):1153-1160. doi: 10.1093/cid/ciz304.
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326 Clinical Usefulness of Bioavailable Vitamin D and Impact of GC Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population.Int J Endocrinol. 2019 Jan 13;2019:9120467. doi: 10.1155/2019/9120467. eCollection 2019.
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