Details of the Drug

General Information of Drug (ID: DMCY0TI)

Drug Name
Carglumic acid
Synonyms Carbaglu (TN)
Indication
Disease Entry ICD 11 Status REF
Acute hyperammonaemia 5C50.A Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 190.15
Logarithm of the Partition Coefficient (xlogp) -2.4
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 4
Hydrogen Bond Acceptor Count (hbondacc) 5
ADMET Property
Clearance
The renal clearance of drug is 290 mL/min []
Half-life
The concentration or amount of drug in body reduced by one-half in 5.6 hours [2]
Metabolism
The drug is metabolized via the intestinal bacterial flora []
Vd
The volume of distribution (Vd) of drug is 2657 L []
Chemical Identifiers
Formula
C6H10N2O5
IUPAC Name
(2S)-2-(carbamoylamino)pentanedioic acid
Canonical SMILES
C(CC(=O)O)[C@@H](C(=O)O)NC(=O)N
InChI
InChI=1S/C6H10N2O5/c7-6(13)8-3(5(11)12)1-2-4(9)10/h3H,1-2H2,(H,9,10)(H,11,12)(H3,7,8,13)/t3-/m0/s1
InChIKey
LCQLHJZYVOQKHU-VKHMYHEASA-N
Cross-matching ID
PubChem CID
121396
ChEBI ID
CHEBI:71028
CAS Number
1188-38-1
DrugBank ID
DB06775
TTD ID
D0Z0MG
ACDINA ID
D00916
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbamoyl-phosphate synthetase I (CPS1) TT42M75 CPSM_HUMAN Activator [3]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sodium stearyl fumarate E00545 23665634 lubricant
Carmellose sodium E00625 Not Available Disintegrant
Hypromellose E00634 Not Available Coating agent
Hydrophobic colloidal silica E00285 24261 Anticaking agent; Emulsion stabilizing agent; Glidant; Suspending agent; Viscosity-controlling agent
Cellulose microcrystalline E00698 Not Available Adsorbent; Suspending agent; Diluent
⏷ Show the Full List of 6 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Carglumic Acid 200mg tablet for suspension 200mg Tablet For Suspension Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7458).
2 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
3 Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.