Details of the Drug

General Information of Drug (ID: DMD23AX)

Drug Name
Systebryl
Synonyms PTI-19; PTI-51; Systemic AA amyloidosis therapy, ProteoTech
Indication
Disease Entry ICD 11 Status REF
Amyloidosis 5D00 Phase 1 [1]
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 261.23
Logarithm of the Partition Coefficient (xlogp) 1.3
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 5
Hydrogen Bond Acceptor Count (hbondacc) 5
Chemical Identifiers
Formula
C13H11NO5
IUPAC Name
N-(3,4-dihydroxyphenyl)-3,4-dihydroxybenzamide
Canonical SMILES
C1=CC(=C(C=C1C(=O)NC2=CC(=C(C=C2)O)O)O)O
InChI
InChI=1S/C13H11NO5/c15-9-3-1-7(5-11(9)17)13(19)14-8-2-4-10(16)12(18)6-8/h1-6,15-18H,(H,14,19)
InChIKey
XIKSEDLKDYKPTO-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
10038269
CAS Number
633700-15-9
TTD ID
D08QDF

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amyloid beta A4 protein (APP) TTE4KHA A4_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Amyloidosis
ICD Disease Classification 5D00
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Amyloid beta A4 protein (APP) DTT APP 1.60E-02 -0.07 -0.31
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2402).