| 1 |
Acetylcysteine FDA Label
|
| 2 |
Cysteine Hydrochloride FDA Label
|
| 3 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8450).
|
| 4 |
FDA Approved Drug Products from FDA Official Website. 2018. Application Number: (ANDA) 210922.
|
| 5 |
ClinicalTrials.gov (NCT02175004) Open-Label Extension Assessing Long Term Safety and Efficacy of ISIS-TTR Rx in Familial Amyloid Polyneuropathy (FAP). U.S. National Institutes of Health.
|
| 6 |
Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
|
| 7 |
ClinicalTrials.gov (NCT02319005) ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC). U.S. National Institutes of Health.
|
| 8 |
ClinicalTrials.gov (NCT00807872) Radioimmunoimaging of AL Amyloidosis. U.S. National Institutes of Health.
|
| 9 |
Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011).
|
| 10 |
ClinicalTrials.gov (NCT01777243) A Study to Evaluate the Safety of GSK2398852 When Co-administered With GSK2315698 in Patients With Systemic Amyloidosis. U.S. National Institutes of Health.
|
| 11 |
URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8255).
|
| 12 |
Systemic and cerebral amyloidosis. Ann Med. 1989;21(2):69-72.
|
| 13 |
Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011960)
|
| 14 |
Deferiprone ameliorates memory impairment in Scopolamine-treated rats: The impact of its iron-chelating effect on -amyloid disposition.Behav Brain Res. 2020 Jan 27;378:112314. doi: 10.1016/j.bbr.2019.112314. Epub 2019 Oct 20.
|
| 15 |
Age- and sex-dependent profiles of APP fragments and key secretases align with changes in despair-like behavior and cognition in young APPSwe/Ind mice.Biochem Biophys Res Commun. 2019 Apr 2;511(2):454-459. doi: 10.1016/j.bbrc.2019.02.083. Epub 2019 Feb 22.
|
| 16 |
Long-term consumption of alcohol exacerbates neural lesions by destroying the functional integrity of the blood-brain barrier.Drug Chem Toxicol. 2022 Jan;45(1):231-238. doi: 10.1080/01480545.2019.1681444. Epub 2019 Nov 20.
|
| 17 |
Design, synthesis and evaluation of novel ferulic acid derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.Bioorg Chem. 2020 Jan;94:103413. doi: 10.1016/j.bioorg.2019.103413. Epub 2019 Oct 30.
|
| 18 |
Latent role of in vitro Pb exposure in blocking Abeta clearance and triggering epigenetic modifications. Environ Toxicol Pharmacol. 2019 Feb;66:14-23.
|
| 19 |
Resveratrol Attenuates the Cytotoxicity Induced by Amyloid-(1-42) in PC12 Cells by Upregulating Heme Oxygenase-1 via the PI3K/Akt/Nrf2 Pathway.Neurochem Res. 2018 Feb;43(2):297-305. doi: 10.1007/s11064-017-2421-7. Epub 2017 Oct 31.
|
| 20 |
In vivo localization of human acetylcholinesterase-derived species in a -sheet conformation at the core of senile plaques in Alzheimer's disease.J Biol Chem. 2019 Apr 19;294(16):6253-6272. doi: 10.1074/jbc.RA118.006230. Epub 2019 Feb 20.
|
| 21 |
Incremental value of amyloid-PET versus CSF in the diagnosis of Alzheimer's disease.Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):270-280. doi: 10.1007/s00259-019-04466-6. Epub 2019 Aug 6.
|
| 22 |
An In Vitro elucidation of the antiaggregatory potential of Diosminover thermally induced unfolding of hen egg white lysozyme; A preventive quest for lysozyme amyloidosis.Int J Biol Macromol. 2019 May 15;129:1015-1023. doi: 10.1016/j.ijbiomac.2019.02.107. Epub 2019 Feb 19.
|
| 23 |
Berberine mitigates cognitive decline in an Alzheimer's Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance.Biomed Pharmacother. 2020 Jan;121:109670. doi: 10.1016/j.biopha.2019.109670. Epub 2019 Nov 22.
|
| 24 |
Phosphorylated TDP-43 Staging of Primary Age-Related Tauopathy.Neurosci Bull. 2019 Apr;35(2):183-192. doi: 10.1007/s12264-018-0300-0. Epub 2018 Oct 31.
|
| 25 |
Clusterin Is Required for -Amyloid Toxicity in Human iPSC-Derived Neurons.Front Neurosci. 2018 Jul 25;12:504. doi: 10.3389/fnins.2018.00504. eCollection 2018.
|
| 26 |
Early Presymptomatic Changes in the Proteome of Mitochondria-Associated Membrane in the APP/PS1 Mouse Model of Alzheimer's Disease.Mol Neurobiol. 2018 Oct;55(10):7839-7857. doi: 10.1007/s12035-018-0955-6. Epub 2018 Feb 22.
|
| 27 |
Acat1 knockdown gene therapy decreases amyloid- in a mouse model of Alzheimer's disease.Mol Ther. 2013 Aug;21(8):1497-506. doi: 10.1038/mt.2013.118. Epub 2013 Jun 18.
|
| 28 |
Pharmacologic inhibition of 5-lipoxygenase improves memory, rescues synaptic dysfunction, and ameliorates tau pathology in a transgenic model of tauopathy.Biol Psychiatry. 2015 Nov 15;78(10):693-701. doi: 10.1016/j.biopsych.2015.01.015. Epub 2015 Feb 7.
|
| 29 |
The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs.Front Immunol. 2018 Oct 16;9:2382. doi: 10.3389/fimmu.2018.02382. eCollection 2018.
|
| 30 |
Knockout of receptor for advanced glycation end-products attenuates age-related renal lesions.Aging Cell. 2019 Apr;18(2):e12850. doi: 10.1111/acel.12850. Epub 2019 Feb 22.
|
| 31 |
Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene.Exp Eye Res. 2012 Mar;96(1):163-70. doi: 10.1016/j.exer.2011.11.014. Epub 2011 Dec 3.
|
| 32 |
Identification of BACE2 as an avid -amyloid-degrading protease.Mol Neurodegener. 2012 Sep 17;7:46. doi: 10.1186/1750-1326-7-46.
|
| 33 |
Integrative approach to sporadic Alzheimer's disease:deficiency of TYROBPin cerebral A amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing A burden.Mol Psychiatry. 2019 Mar;24(3):431-446. doi: 10.1038/s41380-018-0255-6. Epub 2018 Oct 3.
|
| 34 |
Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target.Int J Mol Sci. 2019 Jun 22;20(12):3050. doi: 10.3390/ijms20123050.
|
| 35 |
Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells.Med Sci Monit. 2018 Aug 13;24:5635-5644. doi: 10.12659/MSM.908765.
|
| 36 |
Amyloid-beta induced paralysis is reduced by cholecalciferol through inhibition of the steroid-signaling pathway in an Alzheimer model of Caenorhabditis elegans.Nutr Neurosci. 2021 Feb;24(2):82-89. doi: 10.1080/1028415X.2019.1596371. Epub 2019 Mar 25.
|
| 37 |
Potential Enzymatic Targets in Alzheimer's: A Comprehensive Review.Curr Drug Targets. 2019;20(3):316-339. doi: 10.2174/1389450119666180820104723.
|
| 38 |
Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.PLoS One. 2017 Mar 23;12(3):e0174875. doi: 10.1371/journal.pone.0174875. eCollection 2017.
|
| 39 |
Chitotriosidase enhances TGF-Smad signaling and uptake of -amyloid in N9 microglia.Neurosci Lett. 2018 Nov 20;687:99-103. doi: 10.1016/j.neulet.2018.09.037. Epub 2018 Sep 21.
|
| 40 |
A novel knock-in mouse model of cryopyrin-associated periodic syndromes with development of amyloidosis: Therapeutic efficacy of proton pump inhibitors.J Allergy Clin Immunol. 2020 Jan;145(1):368-378.e13. doi: 10.1016/j.jaci.2019.05.034. Epub 2019 Jun 10.
|
| 41 |
Genomic and nongenomic signaling induced by 1,25(OH)2-vitamin D3 promotes the recovery of amyloid- phagocytosis by Alzheimer's disease macrophages.J Alzheimers Dis. 2012;29(1):51-62. doi: 10.3233/JAD-2012-110560.
|
| 42 |
CB2 receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.Mol Med. 2014 Mar 14;20(1):29-36. doi: 10.2119/molmed.2013.00140.revised.
|
| 43 |
Higher thrombin activatable fibrinolysis inhibitor levels are associated with inflammation in attack-free familial Mediterranean fever patients.Ren Fail. 2014 Jun;36(5):743-7. doi: 10.3109/0886022X.2014.886935. Epub 2014 Mar 3.
|
| 44 |
Predicting Short-term MCI-to-AD Progression Using Imaging, CSF, Genetic Factors, Cognitive Resilience, and Demographics.Sci Rep. 2019 Feb 19;9(1):2235. doi: 10.1038/s41598-019-38793-3.
|
| 45 |
CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer's disease.Alzheimers Res Ther. 2016 Apr 19;8(1):15. doi: 10.1186/s13195-016-0183-0.
|
| 46 |
Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review.Eur J Med Chem. 2019 May 1;169:185-199. doi: 10.1016/j.ejmech.2019.03.009. Epub 2019 Mar 8.
|
| 47 |
A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.ACS Chem Neurosci. 2018 Jul 18;9(7):1591-1606. doi: 10.1021/acschemneuro.7b00469. Epub 2018 Apr 16.
|
| 48 |
Changed clathrin regulatory proteins in the brains of Alzheimer's disease patients and animal models.J Alzheimers Dis. 2010;22(1):329-42. doi: 10.3233/JAD-2010-100162.
|
| 49 |
Diagnostic accuracy of bone scintigraphy in the assessment of cardiac transthyretin-related amyloidosis: a bivariate meta-analysis.Eur J Nucl Med Mol Imaging. 2018 Oct;45(11):1945-1955. doi: 10.1007/s00259-018-4013-4. Epub 2018 Apr 23.
|
| 50 |
aFGF Promotes Neurite Growth by Regulating GSK3-CRMP2 Signaling Pathway in Cortical Neurons Damaged by Amyloid-.J Alzheimers Dis. 2019;72(1):97-109. doi: 10.3233/JAD-190458.
|
| 51 |
Disrupted hippocampal growth hormone secretagogue receptor 1 interaction with dopamine receptor D1 plays a role in Alzheimer's disease.Sci Transl Med. 2019 Aug 14;11(505):eaav6278. doi: 10.1126/scitranslmed.aav6278.
|
| 52 |
Novel diagnostic features of dysferlinopathies.Muscle Nerve. 2010 Jul;42(1):14-21. doi: 10.1002/mus.21650.
|
| 53 |
Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer's brain.J Neurochem. 2010 Oct;115(1):47-57. doi: 10.1111/j.1471-4159.2010.06899.x. Epub 2010 Jul 30.
|
| 54 |
Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.J Clin Invest. 2019 Feb 1;129(2):820-833. doi: 10.1172/JCI122954. Epub 2019 Jan 22.
|
| 55 |
Markers of cholesterol transport are associated with amyloid deposition in the brain.Neurobiol Aging. 2014 Apr;35(4):802-7. doi: 10.1016/j.neurobiolaging.2013.09.040. Epub 2013 Oct 3.
|
| 56 |
Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label.Phys Chem Chem Phys. 2019 Dec 7;21(45):25187-25195. doi: 10.1039/c9cp01060b. Epub 2019 Nov 7.
|
| 57 |
Amyloid (beta)42 activates a G-protein-coupled chemoattractant receptor, FPR-like-1.J Neurosci. 2001 Jan 15;21(2):RC123. doi: 10.1523/JNEUROSCI.21-02-j0003.2001.
|
| 58 |
Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders.Ann Neurol. 2019 Feb;85(2):259-271. doi: 10.1002/ana.25392. Epub 2019 Jan 7.
|
| 59 |
Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer's disease.Theranostics. 2019 Apr 12;9(8):2268-2281. doi: 10.7150/thno.30649. eCollection 2019.
|
| 60 |
Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease.Aging (Albany NY). 2019 Sep 11;11(17):7257-7273. doi: 10.18632/aging.102260. Epub 2019 Sep 11.
|
| 61 |
Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans. Am J Hum Genet. 2018 Feb 1;102(2):219-232. doi: 10.1016/j.ajhg.2017.12.012. Epub 2018 Jan 11.
|
| 62 |
GluA1 subunit ubiquitination mediates amyloid--induced loss of surface -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.J Biol Chem. 2017 May 19;292(20):8186-8194. doi: 10.1074/jbc.M116.774554. Epub 2017 Apr 4.
|
| 63 |
Probing the putative 7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.PLoS One. 2017 Dec 20;12(12):e0189513. doi: 10.1371/journal.pone.0189513. eCollection 2017.
|
| 64 |
Altered distribution of mGlu2 receptors in -amyloid-affected brain regions of Alzheimer cases and aged PS2APP mice.Brain Res. 2010 Dec 2;1363:180-90. doi: 10.1016/j.brainres.2010.09.072. Epub 2010 Sep 25.
|
| 65 |
Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors.Neuropharmacology. 2017 Sep 1;123:274-286. doi: 10.1016/j.neuropharm.2017.05.008. Epub 2017 May 8.
|
| 66 |
Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer's disease mouse models.Mol Brain. 2018 Apr 10;11(1):19. doi: 10.1186/s13041-018-0364-9.
|
| 67 |
Emerging roles of GSK-3 in pathophysiology: Emphasis on cardio-metabolic disorders.Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118616. doi: 10.1016/j.bbamcr.2019.118616. Epub 2019 Nov 27.
|
| 68 |
Amyloidosis and Ocular Involvement: an Overview.Semin Ophthalmol. 2020 Jan 2;35(1):7-26. doi: 10.1080/08820538.2019.1687738. Epub 2019 Dec 12.
|
| 69 |
CSF pro-orexin and amyloid-38 expression in Alzheimer's disease and frontotemporal dementia.Neurobiol Aging. 2018 Dec;72:171-176. doi: 10.1016/j.neurobiolaging.2018.08.019. Epub 2018 Aug 25.
|
| 70 |
Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11148-E11157. doi: 10.1073/pnas.1805436115. Epub 2018 Nov 5.
|
| 71 |
Genetic resilience to amyloid related cognitive decline.Brain Imaging Behav. 2017 Apr;11(2):401-409. doi: 10.1007/s11682-016-9615-5.
|
| 72 |
Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.Acta Neuropathol. 2006 Feb;111(2):139-49. doi: 10.1007/s00401-005-0030-z. Epub 2006 Feb 17.
|
| 73 |
Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease.J Alzheimers Dis. 2016 May 7;53(1):349-61. doi: 10.3233/JAD-160046.
|
| 74 |
The serine protease HtrA1 cleaves misfolded transforming growth factor -induced protein (TGFBIp) and induces amyloid formation.J Biol Chem. 2019 Aug 2;294(31):11817-11828. doi: 10.1074/jbc.RA119.009050. Epub 2019 Jun 13.
|
| 75 |
Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity.Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19165-19175. doi: 10.1073/pnas.1904563116. Epub 2019 Sep 4.
|
| 76 |
Angiotensin Converting Enzyme Gene Insertion/Deletion Variant and Familial Mediterranean Fever-related Amyloidosis.Iran J Kidney Dis. 2018 May;12(3):150-155.
|
| 77 |
Orientin Improves Cognition by Enhancing Autophagosome Clearance in an Alzheimer's Mouse Model.J Mol Neurosci. 2019 Oct;69(2):246-253. doi: 10.1007/s12031-019-01353-5. Epub 2019 Jun 26.
|
| 78 |
Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model.Exp Neurol. 2020 Feb;324:113115. doi: 10.1016/j.expneurol.2019.113115. Epub 2019 Nov 14.
|
| 79 |
AH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: a case report.Amyloid. 2008 Jun;15(2):125-8. doi: 10.1080/13506120802006229.
|
| 80 |
Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein.Amyloid. 2020 Mar;27(1):25-35. doi: 10.1080/13506129.2019.1675623. Epub 2019 Oct 15.
|
| 81 |
Human LilrB2 is a -amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.Science. 2013 Sep 20;341(6152):1399-404. doi: 10.1126/science.1242077.
|
| 82 |
Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against -amyloid.Sci Signal. 2019 Jun 25;12(587):eaaw9318. doi: 10.1126/scisignal.aaw9318.
|
| 83 |
Vascular alterations in apolipoprotein A-I amyloidosis (Leu75Pro). A case-control study.Amyloid. 2015;22(3):187-93. doi: 10.3109/13506129.2015.1066771. Epub 2015 Jul 25.
|
| 84 |
Antibodies to myelin-associated glycoprotein (anti-Mag) in IgM amyloidosis may influence expression of neuropathy in rare patients.Muscle Nerve. 2008 Apr;37(4):490-5. doi: 10.1002/mus.20955.
|
| 85 |
The Rho kinase inhibitor fasudil attenuates A(1-42)-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons.Metab Brain Dis. 2019 Dec;34(6):1787-1801. doi: 10.1007/s11011-019-00487-0. Epub 2019 Sep 3.
|
| 86 |
URMC-099 facilitates amyloid- clearance in a murine model of Alzheimer's disease.J Neuroinflammation. 2018 May 5;15(1):137. doi: 10.1186/s12974-018-1172-y.
|
| 87 |
SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription.J Biol Chem. 2002 Nov 29;277(48):46822-30. doi: 10.1074/jbc.M206299200. Epub 2002 Sep 20.
|
| 88 |
Age-associated proteomic alterations in human aortic media.Geriatr Gerontol Int. 2019 Oct;19(10):1054-1062. doi: 10.1111/ggi.13757. Epub 2019 Aug 21.
|
| 89 |
Amyloidosis, synucleinopathy, and prion encephalopathy in a neuropathic lysosomal storage disease: the CNS-biomarker potential of peripheral blood.PLoS One. 2013 Nov 21;8(11):e80142. doi: 10.1371/journal.pone.0080142. eCollection 2013.
|
| 90 |
Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer's Disease Model Mice Targeting Beta-Amyloid Production.Front Pharmacol. 2017 Mar 8;8:106. doi: 10.3389/fphar.2017.00106. eCollection 2017.
|
| 91 |
Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk.Atherosclerosis. 2012 Jul;223(1):230-4. doi: 10.1016/j.atherosclerosis.2012.04.021. Epub 2012 May 8.
|
| 92 |
Higher levels of kallikrein-8 in female brain may increase the risk for Alzheimer's disease.Brain Pathol. 2018 Nov;28(6):947-964. doi: 10.1111/bpa.12599. Epub 2018 Apr 10.
|
| 93 |
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.J Neurosci. 2006 Oct 25;26(43):10949-57. doi: 10.1523/JNEUROSCI.2793-06.2006.
|
| 94 |
Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body".J Neurochem. 2001 Jul;78(1):121-8. doi: 10.1046/j.1471-4159.2001.00379.x.
|
| 95 |
Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in A-induced mitochondrial dysfunction.J Comput Aided Mol Des. 2017 Oct;31(10):929-941. doi: 10.1007/s10822-017-0067-9. Epub 2017 Sep 14.
|
| 96 |
Islet Interleukin-1 Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to -Cell Failure.Diabetes Care. 2018 Apr;41(4):823-830. doi: 10.2337/dc17-1387. Epub 2018 Feb 1.
|
| 97 |
Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.Neurobiol Aging. 2015 Apr;36(4):1629-1638. doi: 10.1016/j.neurobiolaging.2015.01.001. Epub 2015 Jan 7.
|
| 98 |
Presenilin 2 deficiency facilitates A-induced neuroinflammation and injury by upregulating P2X7 expression.Sci China Life Sci. 2017 Feb;60(2):189-201. doi: 10.1007/s11427-016-0347-4. Epub 2017 Jan 23.
|
| 99 |
Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates A Oligomer-Induced Cognitive Impairments in Mice.Front Mol Neurosci. 2017 Nov 28;10:393. doi: 10.3389/fnmol.2017.00393. eCollection 2017.
|
| 100 |
Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer's Disease.J Med Chem. 2017 Aug 10;60(15):6664-6677. doi: 10.1021/acs.jmedchem.7b00648. Epub 2017 Jul 25.
|
| 101 |
Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce -Amyloid Plaques in Alzheimer's Disease Mouse Model.Mol Pharm. 2019 Feb 4;16(2):480-488. doi: 10.1021/acs.molpharmaceut.8b00096. Epub 2018 Dec 31.
|
| 102 |
Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model.Neurosci Lett. 2019 Apr 23;699:199-205. doi: 10.1016/j.neulet.2019.02.012. Epub 2019 Feb 10.
|
| 103 |
Flow cytometry-based immunophenotypic analysis of primary systemic light chain amyloidosis.Oncol Lett. 2017 Apr;13(4):2691-2697. doi: 10.3892/ol.2017.5767. Epub 2017 Feb 22.
|
| 104 |
Inflammation-induced iron transport and metabolism by brain microglia.J Biol Chem. 2018 May 18;293(20):7853-7863. doi: 10.1074/jbc.RA118.001949. Epub 2018 Apr 2.
|
| 105 |
Astrocytic glutamatergic transporters are involved in A-induced synaptic dysfunction.Brain Res. 2018 Jan 1;1678:129-137. doi: 10.1016/j.brainres.2017.10.011. Epub 2017 Oct 21.
|
| 106 |
GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease.Mol Neurobiol. 2020 Feb;57(2):798-805. doi: 10.1007/s12035-019-01743-1. Epub 2019 Aug 31.
|
| 107 |
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.Nat Commun. 2019 Aug 29;10(1):3885. doi: 10.1038/s41467-019-11813-6.
|
| 108 |
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins.Glia. 2020 Feb;68(2):407-421. doi: 10.1002/glia.23728. Epub 2019 Oct 9.
|
| 109 |
Properties of NACP/alpha-synuclein and its role in Alzheimer's disease.Biochim Biophys Acta. 2000 Jul 26;1502(1):95-109. doi: 10.1016/s0925-4439(00)00036-3.
|
| 110 |
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis.Antioxid Redox Signal. 2019 Apr 10;30(11):1411-1431. doi: 10.1089/ars.2017.7440. Epub 2018 Apr 25.
|
| 111 |
Liver X Receptor Agonist GW3965 Regulates Synaptic Function upon Amyloid Beta Exposure in Hippocampal Neurons.Neurotox Res. 2018 Apr;33(3):569-579. doi: 10.1007/s12640-017-9845-3. Epub 2018 Jan 3.
|
| 112 |
Triggering microglia through toll-like receptor 2 pathway induced interferon expression in cell and animal model of Alzheimer's disease.Neuroreport. 2018 Dec 5;29(17):1456-1462. doi: 10.1097/WNR.0000000000001132.
|
| 113 |
Preclinical data support leveraging CS1 chimeric antigen receptor T-cell therapy for systemic light chain amyloidosis.Cytotherapy. 2017 Jul;19(7):861-866. doi: 10.1016/j.jcyt.2017.03.077. Epub 2017 May 5.
|
| 114 |
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.EMBO Mol Med. 2018 Apr;10(4):e8300. doi: 10.15252/emmm.201708300.
|
| 115 |
Curcumin restores innate immune Alzheimer's disease risk gene expression to ameliorate Alzheimer pathogenesis.Neurobiol Dis. 2019 Jul;127:432-448. doi: 10.1016/j.nbd.2019.02.015. Epub 2019 Apr 2.
|
| 116 |
Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairment.Mol Psychiatry. 2018 Mar;23(3):767-776. doi: 10.1038/mp.2017.136. Epub 2017 Jul 11.
|
| 117 |
Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression.Mol Neurobiol. 2019 Sep;56(9):6539-6550. doi: 10.1007/s12035-019-1540-3. Epub 2019 Mar 9.
|
| 118 |
Neuropathological findings in cerebral B-protein amyloidosis. Differences and similarities in those cases presenting as a cerebral hemorrhage and those presenting as a dementia of the Alzheimer type.Clin Neurol Neurosurg. 1992;94 Suppl:S52-3. doi: 10.1016/0303-8467(92)90021-t.
|
| 119 |
Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex.Mol Neurobiol. 2017 Aug;54(6):4172-4188. doi: 10.1007/s12035-016-9964-5. Epub 2016 Jun 21.
|
| 120 |
A frame shift mutation in the fibrinogen A alpha chain gene in a kindred with renal amyloidosis.Blood. 1996 May 15;87(10):4197-203.
|
| 121 |
ABCA7 and Pathogenic Pathways of Alzheimer's Disease.Brain Sci. 2018 Feb 5;8(2):27. doi: 10.3390/brainsci8020027.
|
| 122 |
Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs.ACS Chem Biol. 2019 Jul 19;14(7):1410-1417. doi: 10.1021/acschembio.9b00394. Epub 2019 Jun 13.
|
| 123 |
Early and severe amyloidosis in a patient with concurrent familial Mediterranean fever and pseudoxanthoma elasticum.Br J Dermatol. 2006 Jun;154(6):1190-3. doi: 10.1111/j.1365-2133.2006.07187.x.
|
| 124 |
Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration.J Neurosci. 2012 Oct 31;32(44):15565-76. doi: 10.1523/JNEUROSCI.3668-12.2012.
|
| 125 |
Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals.Neuroimage Clin. 2017 Oct 31;17:388-396. doi: 10.1016/j.nicl.2017.10.034. eCollection 2018.
|
| 126 |
Asymmetric dimethylarginine exacerbates A-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.Free Radic Biol Med. 2015 Feb;79:117-26. doi: 10.1016/j.freeradbiomed.2014.12.002. Epub 2014 Dec 12.
|
| 127 |
Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.J Mol Neurosci. 2011 Mar;43(3):424-7. doi: 10.1007/s12031-010-9460-8. Epub 2010 Oct 13.
|
| 128 |
Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study.Ann Med. 2008;40(3):232-9. doi: 10.1080/07853890701842988.
|
| 129 |
Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7).Neurobiol Dis. 2011 Jan;41(1):33-42. doi: 10.1016/j.nbd.2010.08.016. Epub 2010 Aug 20.
|
| 130 |
BP1 is a negative modulator of definitive erythropoiesis.Nucleic Acids Res. 2006;34(18):5232-7. doi: 10.1093/nar/gkl680. Epub 2006 Sep 26.
|
| 131 |
Testing the 2018 NIA-AA research framework in a retrospective large cohort of patients with cognitive impairment: from biological biomarkers to clinical syndromes.Alzheimers Res Ther. 2019 Oct 15;11(1):84. doi: 10.1186/s13195-019-0543-7.
|
| 132 |
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.J Biol Chem. 2011 Sep 30;286(39):34088-100. doi: 10.1074/jbc.M111.243907. Epub 2011 Aug 8.
|
| 133 |
Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis.J Neurol. 2020 Mar;267(3):703-712. doi: 10.1007/s00415-019-09602-8. Epub 2019 Nov 14.
|
| 134 |
Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis.Cell Mol Life Sci. 2019 May;76(10):1833-1863. doi: 10.1007/s00018-019-03040-5. Epub 2019 Feb 15.
|
| 135 |
ABCG1 and ABCG4 Suppress -Secretase Activity and Amyloid Production.PLoS One. 2016 May 19;11(5):e0155400. doi: 10.1371/journal.pone.0155400. eCollection 2016.
|
| 136 |
Antiamyloidogenic Activity of A42-Binding Peptoid in Modulating Amyloid Oligomerization.Small. 2017 Jan;13(1). doi: 10.1002/smll.201602857. Epub 2016 Oct 7.
|
| 137 |
Deposition of collagen IV and aggrecan in leptomeningeal arteries of hereditary brain haemorrhage with amyloidosis.Brain Res. 2013 Oct 16;1535:106-14. doi: 10.1016/j.brainres.2013.08.029. Epub 2013 Aug 20.
|
| 138 |
In silico-guided identification of potential inhibitors against (2)m aggregation in dialysis-related amyloidosis.J Biomol Struct Dyn. 2020 Aug;38(13):3927-3941. doi: 10.1080/07391102.2019.1668852. Epub 2019 Sep 27.
|
| 139 |
The combination of apolipoprotein E4, age and Alzheimer's Disease Assessment Scale - Cognitive Subscale improves the prediction of amyloid positron emission tomography status in clinically diagnosed mild cognitive impairment.Eur J Neurol. 2019 May;26(5):733-e53. doi: 10.1111/ene.13881. Epub 2019 Jan 20.
|
| 140 |
Amyloidosis and exercise intolerance in ANO5 muscular dystrophy.Neuromuscul Disord. 2012 Jan;22(1):13-5. doi: 10.1016/j.nmd.2011.07.005. Epub 2011 Aug 4.
|
| 141 |
APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.Exp Gerontol. 2013 Apr;48(4):391-4. doi: 10.1016/j.exger.2013.01.013. Epub 2013 Feb 4.
|
| 142 |
By suppressing the expression of anterior pharynx-defective-1 and -1 and inhibiting the aggregation of -amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice.FASEB J. 2015 Dec;29(12):5044-58. doi: 10.1096/fj.15-275578. Epub 2015 Aug 20.
|
| 143 |
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.Hum Genet. 1998 Feb;102(2):192-6. doi: 10.1007/s004390050676.
|
| 144 |
Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.Folia Neuropathol. 2018;56(1):30-38. doi: 10.5114/fn.2018.74657.
|
| 145 |
Novel Type of Renal Amyloidosis Derived from Apolipoprotein-CII.J Am Soc Nephrol. 2017 Feb;28(2):439-445. doi: 10.1681/ASN.2015111228. Epub 2016 Jun 13.
|
| 146 |
The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.Mol Neurobiol. 2018 Feb;55(2):1217-1226. doi: 10.1007/s12035-017-0397-6. Epub 2017 Jan 20.
|
| 147 |
The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by -amyloid or NGF deprivation.Mol Cell Neurosci. 2018 Apr;88:249-257. doi: 10.1016/j.mcn.2018.02.011. Epub 2018 Feb 27.
|
| 148 |
C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.Immunol Lett. 2016 Jan;169:82-92. doi: 10.1016/j.imlet.2015.11.014. Epub 2015 Dec 2.
|
| 149 |
PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease.Brain. 2017 Dec 1;140(12):3233-3251. doi: 10.1093/brain/awx258.
|
| 150 |
Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer's disease.Neural Regen Res. 2019 Dec;14(12):2147-2155. doi: 10.4103/1673-5374.262593.
|
| 151 |
CART treatment improves memory and synaptic structure in APP/PS1 mice.Sci Rep. 2015 May 11;5:10224. doi: 10.1038/srep10224.
|
| 152 |
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia.J Neurosci. 2017 Oct 11;37(41):9917-9924. doi: 10.1523/JNEUROSCI.0621-17.2017. Epub 2017 Sep 14.
|
| 153 |
Chaperoning Against Amyloid Aggregation: Monitoring In Vitro and In Vivo.Methods Mol Biol. 2019;1929:135-154. doi: 10.1007/978-1-4939-9030-6_10.
|
| 154 |
A accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.Mol Neurodegener. 2017 Aug 23;12(1):61. doi: 10.1186/s13024-017-0203-y.
|
| 155 |
Novel CHST6 gene mutations in 2 unrelated cases of macular corneal dystrophy.Cornea. 2011 Jun;30(6):664-9. doi: 10.1097/ICO.0b013e3182012888.
|
| 156 |
Sex-specific genetic predictors of Alzheimer's disease biomarkers.Acta Neuropathol. 2018 Dec;136(6):857-872. doi: 10.1007/s00401-018-1881-4. Epub 2018 Jul 2.
|
| 157 |
Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity.Cell Death Dis. 2017 Oct 12;8(10):e3102. doi: 10.1038/cddis.2017.491.
|
| 158 |
The role of calsyntenin-3 in dystrophic neurite formation in Alzheimer's disease brain.Geriatr Gerontol Int. 2016 Mar;16 Suppl 1:43-50. doi: 10.1111/ggi.12737.
|
| 159 |
Metabolic correlates of reserve and resilience in MCI due to Alzheimer's Disease (AD).Alzheimers Res Ther. 2018 Apr 3;10(1):35. doi: 10.1186/s13195-018-0366-y.
|
| 160 |
Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. Am J Hum Genet. 2016 Nov 3;99(5):1117-1129. doi: 10.1016/j.ajhg.2016.09.010. Epub 2016 Oct 20.
|
| 161 |
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.J Mol Neurosci. 2007;31(2):165-70. doi: 10.1385/jmn/31:02:165.
|
| 162 |
Destabilization of -amyloid aggregates by thrombin derived peptide: plausible role of thrombin in neuroprotection.FEBS J. 2020 Jun;287(11):2386-2413. doi: 10.1111/febs.15149. Epub 2020 Jan 3.
|
| 163 |
Human -defensin-3 correlates with muscle fibre degeneration in idiopathic inflammatory myopathies.Innate Immun. 2014 Jan;20(1):49-60. doi: 10.1177/1753425913481820. Epub 2013 Apr 22.
|
| 164 |
Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid- Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.Pharm Res. 2018 Feb 6;35(3):49. doi: 10.1007/s11095-017-2312-2.
|
| 165 |
Effects of Acetylcholine on -Amyloid-Induced cPLA2 Activation in the TB Neuroectodermal Cell Line: Implications for the Pathogenesis of Alzheimer's Disease.Cell Mol Neurobiol. 2018 May;38(4):817-826. doi: 10.1007/s10571-017-0555-4. Epub 2017 Oct 9.
|
| 166 |
PSD-93 Attenuates Amyloid--Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-.J Alzheimers Dis. 2017;59(3):913-927. doi: 10.3233/JAD-170320.
|
| 167 |
Congophilic Fibrillary Glomerulonephritis: A Case Series.Am J Kidney Dis. 2018 Sep;72(3):325-336. doi: 10.1053/j.ajkd.2018.03.017. Epub 2018 Jun 14.
|
| 168 |
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.Neurobiol Aging. 2017 Jan;49:165-182. doi: 10.1016/j.neurobiolaging.2016.10.003. Epub 2016 Oct 11.
|
| 169 |
Genetic Risk as a Marker of Amyloid- and Tau Burden in Cerebrospinal Fluid.J Alzheimers Dis. 2017;55(4):1417-1427. doi: 10.3233/JAD-160707.
|
| 170 |
scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein.J Cell Biol. 1998 May 18;141(4):1009-17. doi: 10.1083/jcb.141.4.1009.
|
| 171 |
Age-Related Intraneuronal Aggregation of Amyloid- in Endosomes, Mitochondria, Autophagosomes, and Lysosomes.J Alzheimers Dis. 2020;73(1):229-246. doi: 10.3233/JAD-190835.
|
| 172 |
Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.JAMA Neurol. 2018 Mar 1;75(3):328-341. doi: 10.1001/jamaneurol.2017.4198.
|
| 173 |
Fibrinogen alpha amyloidosis: insights from proteomics.Expert Rev Proteomics. 2019 Sep;16(9):783-793. doi: 10.1080/14789450.2019.1659137. Epub 2019 Aug 28.
|
| 174 |
Roles of Mitochondrial 17-Hydroxysteroid Dehydrogenase Type 10 in Alzheimer's Disease.J Alzheimers Dis. 2018;62(2):665-673. doi: 10.3233/JAD-170974.
|
| 175 |
RNA-binding protein FXR1 is presented in rat brain in amyloid form.Sci Rep. 2019 Dec 12;9(1):18983. doi: 10.1038/s41598-019-55528-6.
|
| 176 |
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.Nat Commun. 2013;4:1338. doi: 10.1038/ncomms2334.
|
| 177 |
Evidence of metabolic memory-induced neurodegeneration and the therapeutic effects of glucagon-like peptide-1 receptor agonists via Forkhead box class O.Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):371-377. doi: 10.1016/j.bbadis.2018.11.012. Epub 2018 Nov 20.
|
| 178 |
Acetylcholinesterase and A Aggregation Inhibition by Heterometallic Ruthenium(II)-Platinum(II) Polypyridyl Complexes.Inorg Chem. 2018 Jul 2;57(13):7524-7535. doi: 10.1021/acs.inorgchem.8b00091. Epub 2018 Jun 12.
|
| 179 |
Extracellular Vesicles: A Possible Link between HIV and Alzheimer's Disease-Like Pathology in HIV Subjects?.Cells. 2019 Aug 24;8(9):968. doi: 10.3390/cells8090968.
|
| 180 |
Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.J Neurosci. 2010 Nov 3;30(44):14915-24. doi: 10.1523/JNEUROSCI.3917-10.2010.
|
| 181 |
Autosomal-dominant transthyretin (TTR)-related amyloidosis is not a frequent CMT2 neuropathy "in disguise".Orphanet J Rare Dis. 2018 Oct 4;13(1):177. doi: 10.1186/s13023-018-0917-0.
|
| 182 |
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid- accumulation modifier.Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2638-43. doi: 10.1073/pnas.1307345111. Epub 2014 Feb 4.
|
| 183 |
LECT2 Amyloidosis in Kidney Transplantation: A Report of 5 Cases.Am J Kidney Dis. 2019 Oct;74(4):563-566. doi: 10.1053/j.ajkd.2018.10.016. Epub 2019 May 30.
|
| 184 |
LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease.Behav Brain Res. 2012 Mar 17;228(2):261-71. doi: 10.1016/j.bbr.2011.11.014. Epub 2011 Nov 22.
|
| 185 |
Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer's disease.FASEB J. 2018 Jul;32(7):3536-3546. doi: 10.1096/fj.201700736RR. Epub 2018 Feb 9.
|
| 186 |
The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease.J Alzheimers Dis. 2010;19(2):673-9. doi: 10.3233/JAD-2010-1265.
|
| 187 |
Catalpol protects synaptic proteins from beta-amyloid induced neuron injury and improves cognitive functions in aged rats.Oncotarget. 2017 May 17;8(41):69303-69315. doi: 10.18632/oncotarget.17951. eCollection 2017 Sep 19.
|
| 188 |
-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway.Neuromolecular Med. 2014 Mar;16(1):137-49. doi: 10.1007/s12017-013-8268-4. Epub 2013 Oct 2.
|
| 189 |
Matrix metalloproteinases and their tissue inhibitors in cardiac amyloidosis: relationship to structural, functional myocardial changes and to light chain amyloid deposition.Circ Heart Fail. 2008 Nov;1(4):249-57. doi: 10.1161/CIRCHEARTFAILURE.108.788687. Epub 2008 Oct 14.
|
| 190 |
Characteristic Biomarker and Cognitive Profile in Incipient Mixed Dementia.J Alzheimers Dis. 2020;73(2):597-607. doi: 10.3233/JAD-190651.
|
| 191 |
Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer's disease mouse model.Sci Rep. 2017 Feb 13;7:42370. doi: 10.1038/srep42370.
|
| 192 |
Cu transfer from amyloid-(4-16) to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(ii)-load states.Chem Commun (Camb). 2018 Nov 6;54(89):12634-12637. doi: 10.1039/c8cc06221h.
|
| 193 |
Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15.
|
| 194 |
Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease.J Alzheimers Dis. 2016;51(4):1183-95. doi: 10.3233/JAD-150868.
|
| 195 |
Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls.PLoS One. 2018 May 10;13(5):e0197329. doi: 10.1371/journal.pone.0197329. eCollection 2018.
|
| 196 |
Amyloid-25-35 Upregulates Endogenous Neuroprotectant Neuroglobin via NFB Activation in vitro.J Alzheimers Dis. 2018;64(4):1163-1174. doi: 10.3233/JAD-180163.
|
| 197 |
Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice.Pharm Biol. 2019 Dec;57(1):453-459. doi: 10.1080/13880209.2019.1629463.
|
| 198 |
Novel NLRP12 mutations associated with intestinal amyloidosis in a patient diagnosed with common variable immunodeficiency.Clin Immunol. 2014 Oct;154(2):105-11. doi: 10.1016/j.clim.2014.07.003. Epub 2014 Jul 23.
|
| 199 |
Hsf-1 affects podocyte markers NPHS1, NPHS2 and WT1 in a transgenic mouse model of TTRVal30Met-related amyloidosis.Amyloid. 2013 Sep;20(3):164-72. doi: 10.3109/13506129.2013.814046. Epub 2013 Jul 5.
|
| 200 |
Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain.J Neurosci. 2006 Dec 6;26(49):12735-47. doi: 10.1523/JNEUROSCI.0575-06.2006.
|
| 201 |
Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?.Neurosci Biobehav Rev. 2019 May;100:180-207. doi: 10.1016/j.neubiorev.2019.02.014. Epub 2019 Feb 25.
|
| 202 |
Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms.Mol Med. 2008 May-Jun;14(5-6):318-26. doi: 10.2119/2008-00010.Kestler.
|
| 203 |
Antagonistic Activity of Naphthoquinone-Based Hybrids toward Amyloids Associated with Alzheimer's Disease and Type-2 Diabetes.ACS Chem Neurosci. 2019 Aug 21;10(8):3510-3520. doi: 10.1021/acschemneuro.9b00123. Epub 2019 Jul 8.
|
| 204 |
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects.Trends Genet. 2010 Feb;26(2):84-93. doi: 10.1016/j.tig.2009.12.004. Epub 2010 Jan 18.
|
| 205 |
V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function.Neurobiol Dis. 2019 Sep;129:182-194. doi: 10.1016/j.nbd.2019.05.015. Epub 2019 May 20.
|
| 206 |
Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease.J Neurosci. 2013 Jun 19;33(25):10512-25. doi: 10.1523/JNEUROSCI.5183-12.2013.
|
| 207 |
Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of -amyloid pathology.Neuropharmacology. 2019 Jan;144:377-387. doi: 10.1016/j.neuropharm.2018.11.002. Epub 2018 Nov 11.
|
| 208 |
Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease.Mol Psychiatry. 2020 Dec;25(12):3380-3398. doi: 10.1038/s41380-019-0483-4. Epub 2019 Aug 20.
|
| 209 |
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated A is induced by pyroglutamate-A formation.J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011.
|
| 210 |
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of -amyloid production.Cell Rep. 2013 Dec 26;5(6):1536-51. doi: 10.1016/j.celrep.2013.12.005.
|
| 211 |
Rab21, a Novel PS1 Interactor, Regulates -Secretase Activity via PS1 Subcellular Distribution.Mol Neurobiol. 2018 May;55(5):3841-3855. doi: 10.1007/s12035-017-0606-3. Epub 2017 May 25.
|
| 212 |
Diabetic microcirculatory disturbances and pathologic erythropoiesis are provoked by deposition of amyloid-forming amylin in red blood cells and capillaries.Kidney Int. 2020 Jan;97(1):143-155. doi: 10.1016/j.kint.2019.07.028. Epub 2019 Sep 5.
|
| 213 |
Effects of altered RTN3 expression on BACE1 activity and Alzheimer's neuritic plaques.Rev Neurosci. 2017 Feb 1;28(2):145-154. doi: 10.1515/revneuro-2016-0054.
|
| 214 |
AA amyloidosis associated with a mutated serum amyloid A4 protein.Amyloid. 2009;16(2):84-8. doi: 10.1080/13506120902879905.
|
| 215 |
Bacterial Amyloids: Biogenesis and Biomaterials.Adv Exp Med Biol. 2019;1174:113-159. doi: 10.1007/978-981-13-9791-2_4.
|
| 216 |
Seminal Tract Amyloidosis: Synchronous Amyloidosis of the Seminal Vesicles, Deferent Ducts and Ejaculatory Ducts.Pathol Oncol Res. 2017 Oct;23(4):811-814. doi: 10.1007/s12253-017-0193-7. Epub 2017 Jan 17.
|
| 217 |
Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.CNS Drugs. 2018 Sep;32(9):849-861. doi: 10.1007/s40263-018-0554-0.
|
| 218 |
SH2B1 is Involved in the Accumulation of Amyloid-42 in Alzheimer's Disease.J Alzheimers Dis. 2017;55(2):835-847. doi: 10.3233/JAD-160233.
|
| 219 |
Alkaptonuria is a novel human secondary amyloidogenic disease.Biochim Biophys Acta. 2012 Nov;1822(11):1682-91. doi: 10.1016/j.bbadis.2012.07.011. Epub 2012 Jul 28.
|
| 220 |
Up-regulation of NSP3 by Oligomeric A Accelerates Neuronal Death Through Cas-independent Rap1A Activation.Neuroscience. 2018 Aug 21;386:182-193. doi: 10.1016/j.neuroscience.2018.06.035. Epub 2018 Jun 30.
|
| 221 |
Endophilin 1 knockdown prevents synaptic dysfunction induced by oligomeric amyloid .Mol Med Rep. 2019 Jun;19(6):4897-4905. doi: 10.3892/mmr.2019.10158. Epub 2019 Apr 12.
|
| 222 |
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30.
|
| 223 |
SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates A Accumulation and Memory Deficits in an AD Mouse.Front Cell Neurosci. 2019 Sep 6;13:410. doi: 10.3389/fncel.2019.00410. eCollection 2019.
|
| 224 |
Impact of SORL1 genetic variations on MRI markers in non-demented elders.Oncotarget. 2016 May 31;7(22):31689-98. doi: 10.18632/oncotarget.9300.
|
| 225 |
Amyloid- peptide alteration of tau exon-10 splicing via the GSK3-SC35 pathway.Neurobiol Dis. 2010 Nov;40(2):378-85. doi: 10.1016/j.nbd.2010.06.013. Epub 2010 Jul 6.
|
| 226 |
The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases.Front Neurosci. 2017 May 16;11:254. doi: 10.3389/fnins.2017.00254. eCollection 2017.
|
| 227 |
Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.J Clin Endocrinol Metab. 2006 Aug;91(8):3138-43. doi: 10.1210/jc.2006-0206. Epub 2006 May 30.
|
| 228 |
Synapsin 1 promotes A generation via BACE1 modulation.PLoS One. 2019 Dec 12;14(12):e0226368. doi: 10.1371/journal.pone.0226368. eCollection 2019.
|
| 229 |
Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease.ASN Neuro. 2010 Jul 12;2(3):e00037. doi: 10.1042/AN20100010.
|
| 230 |
TOM1 Regulates Neuronal Accumulation of Amyloid- Oligomers by FcRIIb2 Variant in Alzheimer's Disease.J Neurosci. 2018 Oct 17;38(42):9001-9018. doi: 10.1523/JNEUROSCI.1996-17.2018. Epub 2018 Sep 5.
|
| 231 |
Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer's disease.Toxicol Lett. 2018 Jan 5;282:100-108. doi: 10.1016/j.toxlet.2017.10.021. Epub 2017 Oct 31.
|
| 232 |
Amyloid-, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data.Front Aging Neurosci. 2018 Jun 25;10:193. doi: 10.3389/fnagi.2018.00193. eCollection 2018.
|
| 233 |
Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study.Ann Neurol. 2013 Apr;73(4):529-36. doi: 10.1002/ana.23830. Epub 2013 Feb 19.
|
|
|
|
|
|
|
