Details of the Drug

General Information of Drug (ID: DMDXM2A)

• Drug Name: Naphthalen-2-yl cyclohexylcarbamate
• Synonyms: naphthalen-2-yl cyclohexylcarbamate; CHEMBL77250; NSC204269; AC1L796V; SCHEMBL1690685; ZINC1738803; BDBM50128573; naphthalen-2-yl N-cyclohexylcarbamate; NSC-204269; Cyclohexyl-carbamic acid naphthalen-2-yl ester; US8815951, 110

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 269.34
  Logarithm of the Partition Coefficient (xlogp); 4.4
  Rotatable Bond Count (rotbonds); 3
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 2
• Chemical Identifiers:
  Formula: C17H19NO2
  IUPAC Name: naphthalen-2-yl N-cyclohexylcarbamate
  Canonical SMILES: C1CCC(CC1)NC(=O)OC2=CC3=CC=CC=C3C=C2
  InChI: InChI=1S/C17H19NO2/c19-17(18-15-8-2-1-3-9-15)20-16-11-10-13-6-4-5-7-14(13)12-16/h4-7,10-12,15H,1-3,8-9H2,(H,18,19)
  InChIKey: ZYHUWMGJJOBBCF-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 306585
  TTD ID: D0K5EI

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid amide hydrolase (FAAH)	TTDP1UC	NOUNIPROTAC	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fatty acid amide hydrolase (FAAH)	DTT	NO-GeName	2.65E-01	0.02	0.1

References

• [1] Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors. J Med Chem. 2008 Dec 11;51(23):7327-43.