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ClinicalTrials.gov (NCT04680637) A Phase 2b Dose Ranging Study to Evaluate the Efficacy and Safety of Efavaleukin Alfa in Subjects With Active Systemic Lupus Erythematosus With Inadequate Response to Standard of Care Therapy. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01777256) An Adaptive Phase II Study to Evaluate the Efficacy, Pharmacodynamics, Safety and Tolerability of GSK2586184. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT04433585) A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of LY3471851 (NKTR-358) in Adults With Systemic Lupus Erythematosus. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT01405196) Subcutaneous Treatment In Randomized Subjects To Evaluate Safety And Efficacy In Generalized Lupus Erythematosus. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03334851) A PHASE 1, RANDOMIZED, MULTI-CENTER, DOUBLE-BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE DOSE-ESCALATION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF-06835375 IN SUBJECTS WITH SEROPOSITIVE SYSTEMIC LUPUS ERYTHEMATOSUS OR RHEUMATOID ARTHRITIS. U.S.National Institutes of Health.
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ClinicalTrials.gov (NCT02437890) A Phase II Study to Evaluate Safety and Efficacy of ALX-0061 in Subjects With Systemic Lupus Erythematosus. U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT00960362) An Investigation of AGS-009 in Patients With Systemic Lupus Erythematosus (SLE). U.S. National Institutes of Health.
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ClinicalTrials.gov (NCT03030976) A Study of CD19 Redirected Autologous T Cells for CD19 Positive Systemic Lupus Erythematosus (SLE)
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Human recombinant relaxin-2 does not attenuate hypertension or renal injury but exacerbates vascular dysfunction in a female mouse model of SLE.Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H234-H242. doi: 10.1152/ajpheart.00174.2019. Epub 2019 May 24.
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The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.PLoS Pathog. 2017 Mar 8;13(3):e1006264. doi: 10.1371/journal.ppat.1006264. eCollection 2017 Mar.
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The -675 4G/5G PAI-1 polymorphism confers genetic susceptibility to systemic lupus erythematosus, its clinical manifestations, and comorbidities in Mexican-Mestizo population.Autoimmunity. 2020 Mar;53(2):71-77. doi: 10.1080/08916934.2019.1700957. Epub 2019 Dec 12.
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Defective DNA double-strand break repair in pediatric systemic lupus erythematosus.Arthritis Rheum. 2012 Feb;64(2):568-78. doi: 10.1002/art.33334.
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Pathways of impending disease flare in African-American systemic lupus erythematosus patients.J Autoimmun. 2017 Mar;78:70-78. doi: 10.1016/j.jaut.2016.12.005. Epub 2017 Feb 2.
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Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3551-6. doi: 10.1073/pnas.0306267101. Epub 2004 Feb 26.
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STAT signaling as a marker of SLE disease severity and implications for clinical therapy.Autoimmun Rev. 2019 Feb;18(2):144-154. doi: 10.1016/j.autrev.2018.08.010. Epub 2018 Dec 18.
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The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients.Clin Exp Med. 2008 Dec;8(4):179-85. doi: 10.1007/s10238-008-0006-0. Epub 2008 Sep 27.
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Association of a functional polymorphism in the 3'-untranslated region of SPI1 with systemic lupus erythematosus.Arthritis Rheum. 2011 Mar;63(3):755-63. doi: 10.1002/art.30188.
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Autoantibodies to alpha-fodrin in primary Sjgren's syndrome and SLE detected by an in vitro transcription and translation assay.Clin Exp Rheumatol. 2003 Jan-Feb;21(1):49-56.
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Novel Autoantibodies Related to Cell Death and DNA Repair Pathways in Systemic Lupus Erythematosus.Genomics Proteomics Bioinformatics. 2019 Jun;17(3):248-259. doi: 10.1016/j.gpb.2018.11.004. Epub 2019 Sep 5.
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Altered Homeostasis of Regulatory T Lymphocytes and Differential Regulation of STAT1/STAT5 in CD4+ T Lymphocytes in Childhood-onset Systemic Lupus Erythematosus.J Rheumatol. 2020 Apr;47(4):557-566. doi: 10.3899/jrheum.181418. Epub 2019 Jul 1.
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Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus.Clin Immunol. 2016 Aug;169:1-7. doi: 10.1016/j.clim.2016.06.003. Epub 2016 Jun 6.
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Promoter polymorphisms of the TIM-4 gene are correlated with disease activity in patients with systemic lupus erythematosus.Int J Immunogenet. 2017 Jun;44(3):122-128. doi: 10.1111/iji.12316. Epub 2017 Mar 31.
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Association of novel polymorphisms in TMEM39A gene with systemic lupus erythematosus in a Chinese Han population.BMC Med Genet. 2017 Apr 20;18(1):43. doi: 10.1186/s12881-017-0405-8.
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Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.Clin Immunol. 2009 Dec;133(3):422-7. doi: 10.1016/j.clim.2009.08.014. Epub 2009 Sep 12.
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DcR3 mutations in patients with juvenile-onset systemic lupus erythematosus lead to enhanced lymphocyte proliferation.J Rheumatol. 2013 Aug;40(8):1316-26. doi: 10.3899/jrheum.121285. Epub 2013 Jun 1.
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An Allele-Specific Functional SNP Associated with Two Systemic Autoimmune Diseases Modulates IRF5 Expression by Long-Range Chromatin Loop Formation.J Invest Dermatol. 2020 Feb;140(2):348-360.e11. doi: 10.1016/j.jid.2019.06.147. Epub 2019 Aug 15.
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Genetic Alleles Associated with SLE Susceptibility and Clinical Manifestations in Hispanic Patients from the Dominican Republic.Curr Mol Med. 2019;19(3):164-171. doi: 10.2174/1566524019666190424130809.
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TRAF3IP2 gene and systemic lupus erythematosus: association with disease susceptibility and pericarditis development.Immunogenetics. 2013 Oct;65(10):703-9. doi: 10.1007/s00251-013-0717-6. Epub 2013 Jul 9.
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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.Nat Immunol. 2015 May;16(5):495-504. doi: 10.1038/ni.3143. Epub 2015 Apr 6.
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Association of an IRF5 gene functional polymorphism with Sjgren's syndrome.Arthritis Rheum. 2007 Dec;56(12):3989-94. doi: 10.1002/art.23142.
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SS-56, a novel cellular target of autoantibody responses in Sjgren syndrome and systemic lupus erythematosus.J Clin Invest. 2001 Sep;108(6):861-9. doi: 10.1172/JCI13469.
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Could GILZ Be the Answer to Glucocorticoid Toxicity in Lupus?.Front Immunol. 2019 Jul 17;10:1684. doi: 10.3389/fimmu.2019.01684. eCollection 2019.
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TSGA10 - A target for autoantibodies in autoimmune polyendocrine syndrome type 1 and systemic lupus erythematosus.Scand J Immunol. 2011 Feb;73(2):147-53. doi: 10.1111/j.1365-3083.2010.02486.x.
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TSPAN33 is a novel marker of activated and malignant B cells.Clin Immunol. 2013 Dec;149(3):388-99. doi: 10.1016/j.clim.2013.08.005. Epub 2013 Aug 15.
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Association of the RAVER2 gene with increased susceptibility for ulcerative colitis.Hum Immunol. 2012 Jul;73(7):732-5. doi: 10.1016/j.humimm.2012.04.018. Epub 2012 May 2.
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