Details of the Drug

General Information of Drug (ID: DMGVJBD)

Drug Name
N-Phenyl-5-phenylimidazo[1,5-a]pyrazin-8-amine
Synonyms
CHEMBL426903; 849199-96-8; imidazo[1,5-a]pyrazin-8-amine,n,5-diphenyl-; N-Phenyl-5-phenylimidazo[1,5-a]pyrazin-8-amine; CTK3C9676; DTXSID80658947; BDBM50198371; ZINC28642119; KB-273858; Imidazo[1,5-a]pyrazin-8-amine, N,5-diphenyl-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 286.3
Logarithm of the Partition Coefficient (xlogp) 4.3
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C18H14N4
IUPAC Name
N,5-diphenylimidazo[1,5-a]pyrazin-8-amine
Canonical SMILES
C1=CC=C(C=C1)C2=CN=C(C3=CN=CN32)NC4=CC=CC=C4
InChI
InChI=1S/C18H14N4/c1-3-7-14(8-4-1)16-12-20-18(17-11-19-13-22(16)17)21-15-9-5-2-6-10-15/h1-13H,(H,20,21)
InChIKey
BJCBFPYPEDWTTE-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
44422490
CAS Number
849199-96-8
TTD ID
D0S3FW

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Src (SRC) TT6PKBN SRC_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene c-Src (SRC) DTT SRC 6.45E-01 -0.08 -0.58
Proto-oncogene c-Src (SRC) DTT SRC 2.08E-03 -0.52 -1.62
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke. Bioorg Med Chem. 2007 Jan 15;15(2):868-85.