Details of the Drug

General Information of Drug (ID: DMHETPI)

Drug Name

ISIS-FXI

Indication

Disease Entry	ICD 11	Status	REF
Coagulation defect	3B10.0	Phase 2	[1]
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Drug Type

Antisense drug

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Factor XI messenger RNA (F11 mRNA)	TTDM4ZU	FA11_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

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Molecular Expression Atlas of This Drug

The Studied Disease

Coagulation defect

ICD Disease Classification

3B10.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Factor XI messenger RNA (F11 mRNA)	DTT	F11	8.24E-01	-3.39E-03	-0.04

Molecular Expression Atlas (MEA)

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References

1	ClinicalTrials.gov (NCT01713361) Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).