Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHETPI)

Drug Name
ISIS-FXI Drug Info
Indication
Disease Entry ICD 11 Status REF
Coagulation defect 3B10.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DMHETPI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Factor XI messenger RNA (F11 mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BMS-986177 DM4QHZS Cerebral ischemia 8B11 Phase 2 [3]
IONIS-416858 DM5F0QY Thrombosis DB61-GB90 Phase 2 [4]
alpha-ketothiazole analogue 36 DMN2I3P Alzheimer disease 8A20 Clinical trial [5]
FXI-AS1 DMAZ1NW Thrombosis DB61-GB90 Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Factor XI messenger RNA (F11 mRNA) TTDM4ZU FA11_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT01713361) Active Comparator-Controlled Study to Assess Safety and Efficacy of ISIS-FXIRx in Total Knee Arthroplasty. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
3 Discovery methods of coagulation-inhibiting drugs. Expert Opin Drug Discov. 2017 Dec;12(12):1195-1205.
4 Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
5 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15;16(4):1562-95.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2360).