General Information of Drug (ID: DMHEYOK)

Drug Name
(1'H-Phenothiazin-1'-yl)(piperidin-1-yl)methanone
Synonyms
CHEMBL589252; Phenothiazin-10-yl-piperidin-1-yl-methanone; AC1LE3IL; ChemDiv3_004237; Oprea1_668518; ZINC91249; MolPort-001-995-166; HMS1485A13; STK004206; BDBM50308415; AKOS000643159; CCG-113845; MCULE-9139922844; IDI1_022147; BAS 04087808; phenothiazin-10-yl(piperidin-1-yl)methanone; SR-01000506180; 10H-phenothiazin-10-yl(piperidin-1-yl)methanone; SR-01000506180-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 310.4
Logarithm of the Partition Coefficient (xlogp) 3.8
Rotatable Bond Count (rotbonds) 0
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 2
Chemical Identifiers
Formula
C18H18N2OS
IUPAC Name
phenothiazin-10-yl(piperidin-1-yl)methanone
Canonical SMILES
C1CCN(CC1)C(=O)N2C3=CC=CC=C3SC4=CC=CC=C42
InChI
InChI=1S/C18H18N2OS/c21-18(19-12-6-1-7-13-19)20-14-8-2-4-10-16(14)22-17-11-5-3-9-15(17)20/h2-5,8-11H,1,6-7,12-13H2
InChIKey
ZYAXTAFPNAMCKA-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
705775
TTD ID
D09OPL

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholinesterase (BCHE) TTEB0GD CHLE_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants. Bioorg Med Chem. 2010 Mar 15;18(6):2232-2244.