Details of the Drug

General Information of Drug (ID: DMIV04R)

• Drug Name: Elpetrigine
• Synonyms: ELPETRIGINE; 212778-82-0; JZP-4; 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine; UNII-1X64S9H3ZS; 1X64S9H3ZS; 2,6-DIAMINO-3-(2,3,5-TRICHLOROPHENYL)PYRAZINE; 2,6-DIAMINO-3-(2,3,5-TRICHLOROPHENYL)-PYRAZINE; JZP4; Elpetrigine [USAN:INN]; Elpetrigine (USAN/INN); CHEMBL29919; SCHEMBL978547; ZINC9967; CTK0J9586; NNXUYJFHOVCRSM-UHFFFAOYSA-N; AKOS015966238; AN-29755; ACM212778820; D09609; 778D820; 2,6-Diamino-3-(2,3,5-trichlorophenyl) pyrazine; 2,6-Pyrazinediamine, 3-(2,3,5-trichlorophenyl)-; 2,6-Diamino-3- (2,3,5-trichlorophenyl) pyrazin

Indication

Disease Entry	ICD 11	Status	REF
Bipolar disorder	6A60	Phase 1	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 289.5
  Logarithm of the Partition Coefficient (xlogp); 2.6
  Rotatable Bond Count (rotbonds); 1
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 4
• Chemical Identifiers:
  Formula: C10H7Cl3N4
  IUPAC Name: 3-(2,3,5-trichlorophenyl)pyrazine-2,6-diamine
  Canonical SMILES: C1=C(C=C(C(=C1C2=NC=C(N=C2N)N)Cl)Cl)Cl
  InChI: InChI=1S/C10H7Cl3N4/c11-4-1-5(8(13)6(12)2-4)9-10(15)17-7(14)3-16-9/h1-3H,(H4,14,15,17)
  InChIKey: NNXUYJFHOVCRSM-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 9926001
  CAS Number: 212778-82-0
  TTD ID: D04MGD

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium channel unspecific (CaC)	TT5HONZ	NOUNIPROTAC	Blocker	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027454)
• [2] Clinical pipeline report, company report or official report of Jazz Pharmaceuticals.