General Information of Disease (ID: DISAM7J2)

Disease Name Bipolar disorder
Synonyms
manic-depressive illness; bipolar affective disorder; depressive-manic psych.; major bipolar affective disorder; manic-depressive psychosis; MAFD; manic depression; manic bipolar affective disorder; manic depressive disorder; mixed bipolar disorder; bipolar depression; bipolar disorder manic phase; manic disorder; manic bipolar I disorder; bipolar disorder; manic-depression; major affective disorder
Disease Class 6A60: Bipolar disorder
Definition
A disorder of the brain that causes unusual shifts in mood, energy, activity levels and the ability to carry out day-to-day tasks. Often these moods range and shift from periods of elation and energized behavior to those of hopelessness and depression.
Disease Hierarchy
DISLVMWO: Mood disorder
DISAM7J2: Bipolar disorder
ICD Code
ICD-11
ICD-11: 6A60
ICD-10
ICD-10: F31
Disease Identifiers
MONDO ID
MONDO_0004985
MESH ID
D001714
UMLS CUI
C0005586
MedGen ID
2649
HPO ID
HP:0007302
SNOMED CT ID
13746004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 13 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Acetophenazine DMZV2PJ Approved Small molecular drug [1]
Aripiprazole DM3NUMH Approved Small molecular drug [2]
Cariprazine DMJYDVK Approved Small molecular drug [3]
DP-VPA DMGOXPQ Approved NA [4]
Ketamine DMT5HA4 Approved Small molecular drug [5]
Lamotrigine DM8SXYG Approved Small molecular drug [6]
Levomepromazine DMIKFEL Approved Small molecular drug [7]
Lithium Citrate DMXAVX5 Approved Small molecular drug [8]
Loxapine DM8AI9U Approved Small molecular drug [9]
Modafinil DMYILBE Approved Small molecular drug [10]
Quetiapine DM1N62C Approved Small molecular drug [11]
Ziprasidone DMM58JY Approved Small molecular drug [12]
Zonisamide DM0DTF7 Approved Small molecular drug [13]
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⏷ Show the Full List of 13 Drug(s)
This Disease is Treated as An Indication in 15 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
esamisulpride DMJ5DAB Phase 3 Small molecule [14]
TG-4010 DMWE3GB Phase 2/3 NA [15]
MEM-1003 DMYZU6G Phase 2a Small molecular drug [16]
BIIB074 DMLV1ET Phase 2 NA [17]
Lithium DMZ3OU6 Phase 2 Small molecular drug [18]
Lu-AA39959 DM34FWR Phase 2 NA [19]
RP5063 DMKUE8O Phase 2 NA [2]
SEP--4199 DMA12HB Phase 2 Small molecular drug [20]
AZD-4451 DMJL7F2 Phase 1 NA [21]
Elpetrigine DMIV04R Phase 1 Small molecular drug [22]
LY-2979165 DM16IX2 Phase 1 Small molecular drug [23]
PF-4455242 DMYR7XP Phase 1 Small molecular drug [24]
SEP-378608 DMLIK6F Phase 1 NA [25]
SKL-PSY DM8YNI6 Phase 1 NA [26]
SPN-802 DMPON9E Phase 1 NA [27]
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⏷ Show the Full List of 15 Drug(s)
This Disease is Treated as An Indication in 3 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Licarbazepine DMWUS8N Discontinued in Phase 3 Small molecular drug [16]
PF-217830 DMBDPN2 Discontinued in Phase 2 Small molecular drug [28]
ABS-103 DMIIWRT Terminated NA [30]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
PGX-5188 DMJLR9W Preclinical NA [29]
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This Disease is Treated as An Indication in 5 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CRD-103 DM47LFH Investigative NA [31]
KP-303 DM11MRQ Investigative NA [31]
NP-07 DM47JH3 Investigative NA [31]
NRX-1050 DMFZU4V Investigative NA [31]
PF-03800130 DM5NBVG Investigative NA [32]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 243 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AMD1 TTBFROQ Limited Altered Expression [33]
CAMKK2 TTV298Y Limited Genetic Variation [34]
CD40 TT1ERKL Limited Genetic Variation [35]
EBI3 TTJF68X Limited Biomarker [36]
FAT1 TTGUJYV Limited Biomarker [37]
GRB2 TTEYRJ9 Limited Genetic Variation [38]
GRN TT0LWE3 Limited Biomarker [39]
IGF1 TTT6LOU Limited Biomarker [40]
KMO TTIY56R Limited Altered Expression [41]
MTNR1B TT32JK8 Limited Biomarker [42]
NCAM1 TTVXPHT Limited Altered Expression [43]
NR4A2 TT9HKN3 Limited Altered Expression [44]
NR4A3 TTJQB49 Limited Genetic Variation [45]
P2RX1 TTJW7B3 Limited Biomarker [46]
P2RX3 TT2THBD Limited Biomarker [46]
P2RX4 TT1NLOA Limited Biomarker [46]
P2RY1 TTA93TL Limited Biomarker [46]
P2RY2 TTOZHQC Limited Biomarker [46]
PBRM1 TTH8ZRL Limited Genetic Variation [47]
PDE3B TTN34SQ Limited Genetic Variation [48]
PGC TT7K6AD Limited Genetic Variation [49]
PLCB1 TTLPGU7 Limited Biomarker [50]
ROR1 TTDEJAU Limited Biomarker [50]
RORA TT1TYN7 Limited Genetic Variation [51]
S100B TTQ0V86 Limited Biomarker [52]
SCN11A TTN9VTF Limited Altered Expression [53]
SLC25A4 TTU5A6Q Limited Genetic Variation [54]
TLR1 TTW14D0 Limited Altered Expression [55]
BPI TTXCSDR Disputed Biomarker [56]
ADCY1 TTV1ZSQ moderate Genetic Variation [57]
ALAS1 TTG1FXO moderate Genetic Variation [58]
CDC25B TTR0SWN moderate Genetic Variation [59]
CRP TTWRN6M moderate Altered Expression [60]
CTSF TTJOKD1 moderate Genetic Variation [61]
CUBN TT9YLCR moderate Genetic Variation [62]
DEPTOR TTLYP6D moderate Genetic Variation [63]
GSS TTVEWR4 moderate Genetic Variation [64]
HDAC9 TT8M4E1 moderate Genetic Variation [65]
HTR1E TTCPG9S moderate Genetic Variation [66]
NEK7 TTJ5SWP moderate Genetic Variation [67]
PDE10A TTJW4LU moderate Genetic Variation [68]
RXRG TTH029C moderate Genetic Variation [69]
SLC12A6 TT8DFHE moderate Biomarker [70]
TCF3 TTULOD8 moderate Genetic Variation [71]
TCF7L2 TT80QAL moderate Genetic Variation [72]
THRA TTTSEPU moderate Biomarker [73]
ABCG1 TTMWDGU Strong Genetic Variation [74]
ADCY2 TTBQ9IM Strong Biomarker [48]
ADCYAP1R1 TT5OREU Strong Biomarker [75]
ADGRL3 TTQST3U Strong Genetic Variation [76]
ADM TTV14YH Strong Biomarker [77]
ADRA1A TTNGILX Strong Biomarker [78]
ADRA2C TT2NUT5 Strong Genetic Variation [79]
AGRP TT4DE1O Strong Altered Expression [80]
AGT TT5C0UB Strong Biomarker [81]
AKT1 TTWTSCV Strong Biomarker [82]
AKT2 TTH24WI Strong Biomarker [83]
ALOX12 TT12ABZ Strong Genetic Variation [84]
APP TTE4KHA Strong Biomarker [85]
ARRB2 TT8SO2I Strong Biomarker [86]
ASIC2 TTVMWLP Strong Genetic Variation [87]
ATF4 TTQCKWT Strong Biomarker [88]
ATP1A1 TTWK8D0 Strong Biomarker [89]
ATP1A2 TT5B6HJ Strong Genetic Variation [90]
AVP TTJ8EWH Strong Altered Expression [91]
BCHE TT3MSAO Strong Biomarker [92]
BDKRB2 TTGY8IW Strong Biomarker [93]
BRCA2 TTUARD6 Strong Biomarker [94]
BRD1 TTT09OB Strong Biomarker [95]
CA5A TT75WPO Strong Genetic Variation [96]
CACNA1A TTX4QDJ Strong Biomarker [97]
CACNA1B TT4FDG6 Strong Biomarker [98]
CACNA1D TT7RGTM Strong Biomarker [99]
CALR TTUZ7OA Strong Biomarker [100]
CASP8 TT6SZNG Strong Altered Expression [101]
CBS TTVZJ7G Strong Genetic Variation [102]
CCKAR TTCG0AL Strong Biomarker [103]
CD47 TT28S46 Strong Biomarker [48]
CFP TTLA0VS Strong Biomarker [104]
CHRM2 TTYEG6Q Strong Genetic Variation [105]
CHRNA2 TTF4E0J Strong Biomarker [106]
CIT TT3BKTU Strong Genetic Variation [107]
CRHR2 TTIY658 Strong Biomarker [108]
CRY2 TTAO58M Strong Biomarker [109]
CSNK1E TTA8PLI Strong Genetic Variation [110]
CTLA4 TTI2S1D Strong Biomarker [111]
DBH TTYIP79 Strong Biomarker [112]
DCLK1 TTOHTCY Strong Biomarker [113]
DLG4 TT9PB26 Strong Biomarker [114]
DNMT1 TT6S2FE Strong Biomarker [115]
DPP10 TTOVUPC Strong Genetic Variation [116]
DRD1 TTZFYLI Strong Biomarker [117]
EIF4EBP1 TTKGEBL Strong Biomarker [118]
ERBB3 TTSINU2 Strong Biomarker [119]
ERBB4 TTWALCO Strong Genetic Variation [120]
ESR1 TTZAYWL Strong Biomarker [121]
FADS2 TTT2VDU Strong Genetic Variation [48]
FGFR1 TTRLW2X Strong Biomarker [119]
FGFR2 TTGJVQM Strong Biomarker [122]
FOXP3 TT1X3QF Strong Biomarker [123]
FUT3 TTUPAD7 Strong Biomarker [124]
FZD7 TTUQMO5 Strong Altered Expression [125]
G6PD TTKN8W0 Strong Altered Expression [126]
GABRA1 TT1MPAY Strong Biomarker [127]
GABRA3 TT37EDJ Strong Biomarker [128]
GABRA5 TTNZPQ1 Strong Biomarker [129]
GABRB2 TTZA1NY Strong Biomarker [130]
GABRR1 TT6XFEU Strong Biomarker [131]
GABRR2 TTQMXLS Strong Biomarker [131]
GAD1 TTKGEP3 Strong Genetic Variation [132]
GAD2 TT7UY6K Strong Biomarker [133]
GAL TTXZAJ5 Strong Biomarker [134]
GALC TT5IZRB Strong Altered Expression [135]
GAP43 TTSGLN5 Strong Biomarker [136]
GLO1 TTV9A7R Strong Biomarker [137]
GPRC5D TTHRAPJ Strong Biomarker [138]
GRIK1 TT0MYE2 Strong Biomarker [93]
GRIK2 TT0K5RG Strong Genetic Variation [139]
GRIK4 TTQV6BO Strong Genetic Variation [140]
GRIK5 TTO6LI7 Strong Biomarker [93]
GRM1 TTVBPDM Strong Genetic Variation [141]
GRM4 TTICZ1O Strong Biomarker [142]
GSK3A TTQWAU1 Strong Biomarker [143]
HBA2 TTQO71U Strong Biomarker [144]
HCAR3 TT8WFXV Strong Biomarker [145]
HDAC5 TTUELN5 Strong Biomarker [48]
HIF1A TTSN6QU Strong Biomarker [146]
HLA-A TTHONFT Strong Genetic Variation [147]
HLA-DRB1 TTUXSTW Strong Genetic Variation [147]
HPGDS TTCYE56 Strong Genetic Variation [148]
HPN TT25MVL Strong Genetic Variation [149]
HSP90B1 TTFPKXQ Strong Biomarker [100]
HSPE1 TTWYMFE Strong Biomarker [150]
HTR4 TT07C3Y Strong Biomarker [151]
HTR6 TTJS8PY Strong Genetic Variation [152]
IL2RB TT9721Y Strong Biomarker [153]
IL6 TTT1V78 Strong Altered Expression [60]
INPP1 TTW0PHM Strong Biomarker [154]
INS TTZOPHG Strong Biomarker [155]
ITGAM TTB69FJ Strong Biomarker [156]
ITPR3 TTH1769 Strong Genetic Variation [157]
KLK8 TTH5MRS Strong Genetic Variation [158]
LDHA TTW76JE Strong Biomarker [146]
MAD1L1 TTNE9U7 Strong Genetic Variation [159]
MAPK1 TT4TQBX Strong Altered Expression [160]
MARCKS TTHRM39 Strong Biomarker [161]
MBL2 TTMQDZ5 Strong Genetic Variation [162]
MCHR1 TTX4RTB Strong Biomarker [145]
MCHR2 TTS17MG Strong Biomarker [163]
MECP2 TTTAU9R Strong Altered Expression [164]
MFGE8 TT1GLAJ Strong Altered Expression [44]
MMP10 TTXLEG7 Strong Biomarker [165]
MMP16 TTNP4CU Strong Genetic Variation [166]
MSMB TTYH1ZK Strong Biomarker [167]
MTR TTUTO39 Strong Genetic Variation [168]
MUSK TT6SA0X Strong Genetic Variation [169]
NEDD4 TT1QU6G Strong Biomarker [170]
NISCH TT789FN Strong Biomarker [171]
NOD2 TTYPUHA Strong Genetic Variation [172]
NR1D1 TTAD1O8 Strong Genetic Variation [173]
NR3C1 TTOZRK6 Strong Biomarker [174]
NRN1 TTS05MJ Strong Biomarker [175]
NTRK1 TTTDVOJ Strong Biomarker [176]
NTRK2 TTKN7QR Strong Biomarker [63]
OXTR TTSCIUP Strong Altered Expression [177]
P2RX7 TT473XN Strong Genetic Variation [178]
PDE11A TTTWC79 Strong Biomarker [179]
PDE2A TTJGW1Z Strong Biomarker [180]
PDE4A TTZ97H5 Strong Biomarker [181]
PDE4B TTVIAT9 Strong Biomarker [182]
PDE9A TTZOEBC Strong Biomarker [183]
PFKFB3 TTTHMQJ Strong Biomarker [146]
PLCG1 TT6T4JI Strong Biomarker [184]
PMEL TT8MK59 Strong Biomarker [35]
PNPLA3 TTEUAEH Strong Biomarker [185]
POMC TT21AKM Strong Biomarker [186]
POR TTOQ9GZ Strong Biomarker [187]
PPARD TT2JWF6 Strong Biomarker [188]
PPID TTNAFOU Strong Biomarker [189]
PRKCZ TTBSN0L Strong Biomarker [190]
PROKR2 TTM67AX Strong Genetic Variation [191]
PROM1 TTXMZ81 Strong Genetic Variation [192]
QPCT TTJ7YTV Strong Genetic Variation [193]
RACK1 TTJ10AL Strong Biomarker [194]
REN TTB2MXP Strong Biomarker [195]
RIPK2 TTCQ2E5 Strong Genetic Variation [166]
RORB TTGB2LZ Strong Genetic Variation [173]
RPS6KA2 TT0ZW9O Strong Biomarker [48]
S1PR1 TT9JZCK Strong Biomarker [196]
SCN2A TTLJTUF Strong Genetic Variation [48]
SCN8A TT54ERL Strong Biomarker [197]
SERPINA1 TTA7UJC Strong Altered Expression [198]
SGCG TTSMT9W Strong Biomarker [199]
SIGMAR1 TT5TPI6 Strong Biomarker [200]
SLC1A1 TTG2A6F Strong Biomarker [201]
SLC1A2 TT2F078 Strong Genetic Variation [202]
SLC1A6 TT6KMPN Strong Biomarker [201]
SNAP25 TTYQWA0 Strong Biomarker [203]
SREBF2 TTRQ4AP Strong Biomarker [204]
SRPK2 TTCZEJ9 Strong Biomarker [48]
SSTR5 TT2BC4G Strong Biomarker [205]
STAB1 TTJFEOC Strong Biomarker [206]
STAR TTEI40H Strong Biomarker [207]
STK4 TTCPLVN Strong Biomarker [48]
TACR1 TTZPO1L Strong Biomarker [208]
TGM2 TT2F4OL Strong Biomarker [121]
TLR2 TTY7ZHS Strong Altered Expression [55]
TLR4 TTISGCA Strong Genetic Variation [209]
TLR6 TTWRI8V Strong Biomarker [55]
TNF TTF8CQI Strong Biomarker [210]
TNFSF12 TTBTDM1 Strong Altered Expression [211]
TPO TT52XDZ Strong Biomarker [212]
TRPC3 TTNVC34 Strong Biomarker [213]
TRPC7 TT06GRA Strong Altered Expression [214]
TRPM2 TTEBMN7 Strong Biomarker [215]
TRPV6 TTBK14N Strong Biomarker [216]
TSPO TTPTXIN Strong Altered Expression [217]
UBC TTBP3XA Strong Genetic Variation [218]
UTS2 TTERU0T Strong Biomarker [219]
UTS2R TTW5UDX Strong Biomarker [220]
VDR TTK59TV Strong Genetic Variation [221]
VIPR2 TT4O5P0 Strong Biomarker [222]
YWHAH TTADIOY Strong Biomarker [223]
ZUP1 TTZC0KV Strong Genetic Variation [94]
ADRB2 TTG8ZWP Definitive Biomarker [224]
CNR2 TTMSFAW Definitive Biomarker [225]
DNAJB1 TTPXAWS Definitive Biomarker [226]
FYN TT2B9KF Definitive Biomarker [227]
GRIA3 TT82EZV Definitive Biomarker [228]
GRM5 TTHS256 Definitive Biomarker [229]
HLA-G TTLKFB3 Definitive Biomarker [230]
HSPA5 TTW26OG Definitive Altered Expression [231]
HTR5A TTRUFDT Definitive Biomarker [232]
IL1RN TT6GSR3 Definitive Biomarker [233]
ITPR1 TT5HWAT Definitive Biomarker [234]
KCNQ2 TTPXI3S Definitive Biomarker [235]
KCNQ3 TTIVDM3 Definitive Altered Expression [235]
MC2R TTPWFDX Definitive Biomarker [236]
SLC18A2 TTNZRI3 Definitive Biomarker [237]
SLC1A3 TT8WRDA Definitive Biomarker [202]
SOD2 TT9O4C5 Definitive Biomarker [238]
SST TTWF7UG Definitive Altered Expression [239]
VIP TTGTWLF Definitive Biomarker [240]
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⏷ Show the Full List of 243 DTT(s)
This Disease Is Related to 12 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC25A17 DTYR5U7 Limited Genetic Variation [48]
CACNG2 DTRL7OG Disputed Biomarker [241]
CACNB2 DTBZWL4 moderate Biomarker [242]
SLC25A26 DT8HR5O moderate Genetic Variation [62]
SLC4A10 DT7RYVF moderate Genetic Variation [69]
SLC14A2 DT8QC7K Strong Biomarker [220]
SLC17A6 DT5LHCR Strong Altered Expression [243]
SLC18A1 DTM953D Strong Biomarker [244]
SLC25A6 DTLMGFJ Strong Genetic Variation [245]
SLC39A3 DTH08M7 Strong Biomarker [246]
SLC5A3 DT8ACN1 Strong Biomarker [247]
SLC6A13 DTX8KP0 Strong Biomarker [205]
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⏷ Show the Full List of 12 DTP(s)
This Disease Is Related to 16 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
THOP1 DE95LJC Limited Genetic Variation [248]
AKR1C4 DEAJN47 Strong Biomarker [249]
AS3MT DE9KJP3 Strong Genetic Variation [250]
CHDH DEAHED0 Strong Altered Expression [251]
FADS1 DE05S8C Strong Genetic Variation [48]
GSTZ1 DEQPEMB Strong Genetic Variation [252]
HINT1 DEWJATF Strong Biomarker [253]
LARS2 DEP7BTH Strong Genetic Variation [254]
NNMT DECVGJ3 Strong Biomarker [255]
NT5C2 DE1DOKJ Strong Genetic Variation [250]
PTGDS DER3H9C Strong Biomarker [256]
SPR DEJVDAT Strong Genetic Variation [257]
ASMT DEHGR57 Definitive Genetic Variation [258]
GSTM1 DEYZEJA Definitive Genetic Variation [148]
GSTT1 DE3PKUG Definitive Genetic Variation [148]
SAT1 DEMWO83 Definitive Biomarker [259]
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⏷ Show the Full List of 16 DME(s)
This Disease Is Related to 449 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACACA OT5CQPZY Limited Altered Expression [260]
ACSL4 OTI71MUJ Limited Biomarker [261]
AKAP6 OTN59BZS Limited Genetic Variation [48]
ANKS1B OT26DGM9 Limited Genetic Variation [48]
ARHGEF7 OT9BPJCL Limited Genetic Variation [35]
ASAP2 OTGEXULW Limited Genetic Variation [48]
ASCC1 OTH4VAP9 Limited Genetic Variation [35]
ATP2B2 OT1NPZ9T Limited Genetic Variation [48]
BABAM2 OTOY7FNT Limited Genetic Variation [48]
BCL11B OT8KKCVJ Limited Genetic Variation [48]
BICC1 OTYRKIJ1 Limited Biomarker [262]
BMS1 OTEGQ8ZO Limited Altered Expression [260]
CADM2 OT45PVKC Limited Genetic Variation [48]
CDAN1 OTCVZRG6 Limited Genetic Variation [48]
COL9A3 OTCUJOEK Limited Biomarker [263]
CUL4A OTTBV70J Limited Genetic Variation [48]
DCBLD1 OTA702JK Limited Genetic Variation [48]
DGCR2 OTEGL17Z Limited Biomarker [263]
DRP2 OTWR7WGU Limited Genetic Variation [264]
FASTK OTTHFZMP Limited Biomarker [265]
GPR50 OT0EJBM4 Limited Genetic Variation [138]
GSDME OT1ZWY32 Limited Genetic Variation [48]
HDGFL3 OTNN7WYH Limited Biomarker [266]
HLF OTTRK9XN Limited Genetic Variation [48]
HOMER1 OTWFD3SI Limited Genetic Variation [267]
IL18R1 OT83XMPQ Limited Biomarker [36]
IQCH OTEYWCIW Limited Genetic Variation [48]
JADE2 OTVG2MYF Limited Genetic Variation [48]
KDM3B OTZU5J5S Limited Genetic Variation [48]
KIF15 OTJRJEXL Limited Genetic Variation [48]
MACROD1 OTWFEVRW Limited Genetic Variation [48]
MINDY2 OTQYW1J3 Limited Biomarker [268]
MRPL33 OTA3YDH0 Limited Genetic Variation [48]
P2RX2 OT0LF34A Limited Biomarker [46]
P2RX5 OTLBR20R Limited Biomarker [46]
P2RX6 OT1FNTXA Limited Biomarker [46]
PARP10 OTILI1DU Limited Genetic Variation [48]
PDLIM7 OTAZVODU Limited Biomarker [269]
PIK3C2A OTFBU4GD Limited Genetic Variation [270]
PRPF6 OT3U0ABN Limited Genetic Variation [54]
RBKS OTDG01Y9 Limited Genetic Variation [48]
SNU13 OTH56TIH Limited Genetic Variation [271]
SNX7 OTO8J1D0 Limited Altered Expression [272]
SYNGR1 OT0MBUK5 Limited Autosomal dominant [273]
SYNJ1 OTTE02XC Limited Biomarker [274]
TENM4 OT91K3FC Limited Genetic Variation [159]
TIMELESS OTD8DCBJ Limited Genetic Variation [110]
TLCD4 OT7411EE Limited Genetic Variation [48]
TSBP1 OT5GE8IO Limited Genetic Variation [48]
TTLL6 OTHBM3DX Limited Genetic Variation [270]
GPRC5C OT45AJT3 Disputed Biomarker [138]
ACTL7A OT840164 moderate Genetic Variation [275]
AMPD3 OT5SP1KJ moderate Genetic Variation [276]
ARHGAP8 OT19H5Q9 moderate Genetic Variation [62]
ARHGEF10L OTUAMHIZ moderate Genetic Variation [275]
ARHGEF15 OTGHDJFP moderate Genetic Variation [159]
ATP6V1E2 OTNNHL6G moderate Genetic Variation [275]
C11orf21 OTJGXDHK moderate Genetic Variation [275]
CABLES1 OTMN4XSX moderate Genetic Variation [275]
CCDC102B OTVDZVD0 moderate Genetic Variation [275]
CEP85L OTSHJFOT moderate Genetic Variation [69]
CFAP57 OT0P6D3O moderate Genetic Variation [277]
CGNL1 OTRE9DGT moderate Genetic Variation [278]
CNTN5 OTWU5FLZ moderate Biomarker [279]
CPNE8 OTO6U97G moderate Genetic Variation [159]
CSMD1 OTIVDSC4 moderate Biomarker [280]
CSMD2 OT541Z3W moderate Genetic Variation [65]
DDN OTM52ZF5 moderate Genetic Variation [281]
EBNA1BP2 OTBRVMZH moderate Genetic Variation [277]
FAM177A1 OTXTA14N moderate Genetic Variation [57]
FAM178B OT8HMHFD moderate Genetic Variation [57]
FBLN1 OT5MHHOP moderate Genetic Variation [282]
GFRA2 OT34CXNN moderate Genetic Variation [65]
GLT8D1 OTG14TPO moderate Genetic Variation [47]
GNL3 OTILGYO4 moderate Genetic Variation [47]
GRAMD1B OTCG1GX2 moderate Genetic Variation [57]
IGSF9B OTNOMYYQ moderate Genetic Variation [159]
INTS7 OT7ZG99E moderate Genetic Variation [282]
IPO8 OTBHGNKT moderate Genetic Variation [275]
KCNMB2 OTBXUQGK moderate Genetic Variation [283]
KCTD7 OTRU3EOK moderate Biomarker [284]
KMT2D OTTVHCLY moderate Genetic Variation [159]
KSR2 OTSMUL59 moderate Genetic Variation [275]
LHFPL3 OTG1EI22 moderate Genetic Variation [65]
LMO7 OTDLY6TC moderate Genetic Variation [275]
LTN1 OTIW2HTX moderate Genetic Variation [275]
MACROD2 OTNQCHC6 moderate Genetic Variation [47]
MAU2 OTALDF8Q moderate Genetic Variation [285]
MCTP1 OTSFI0HS moderate Genetic Variation [61]
MGAT4A OT0ZW5FM moderate Genetic Variation [67]
NFIA OTDHQ9CG moderate Genetic Variation [286]
NFIX OT1DPZAE moderate Genetic Variation [159]
NFYC OTZVVEV7 moderate Genetic Variation [63]
NUMB OTMB586Q moderate Genetic Variation [287]
PCDH12 OT2VANLI moderate Genetic Variation [275]
PGAP3 OTH9A75E moderate Genetic Variation [281]
PHF7 OTDRYXSD moderate Genetic Variation [47]
PLCB4 OTPA0QHW moderate Genetic Variation [275]
PRSS35 OT09H6WH moderate Genetic Variation [287]
PTPRG OT9N2WOF moderate Genetic Variation [69]
PTS OTTYWQXR moderate Genetic Variation [71]
RAB40B OTCA9ZF5 moderate Genetic Variation [288]
RASAL2 OTGMMX6W moderate Genetic Variation [159]
RASIP1 OTCRY2AN moderate Genetic Variation [64]
RBMS3 OTFSC9MR moderate Genetic Variation [289]
RNLS OTVP2WJM moderate Genetic Variation [63]
RPN2 OTJ1SKOA moderate Genetic Variation [275]
SDCCAG8 OTV2ZGV9 moderate Genetic Variation [290]
SH2B1 OTJZO2CI moderate Genetic Variation [58]
SLC35F4 OTTYQZ3F moderate Genetic Variation [59]
SLIT1 OT35RBNT moderate Genetic Variation [159]
SMIM8 OTCNLUXF moderate Genetic Variation [63]
SPCS1 OTUHQ4UC moderate Genetic Variation [47]
SPG11 OTZ7LJX4 moderate CausalMutation [291]
SPTLC1 OTN0Z98K moderate Genetic Variation [283]
STX2 OTO2IDDR moderate Genetic Variation [275]
TLE4 OT4QEH6T moderate Genetic Variation [59]
TMEM132C OT3297S6 moderate Genetic Variation [292]
TMPRSS5 OTERB7Z4 moderate Genetic Variation [275]
TRANK1 OT7DH5H4 moderate Biomarker [48]
TRIM42 OT7STGWH moderate Genetic Variation [277]
TRPC4AP OTNJ9IFS moderate Genetic Variation [64]
TSPAN8 OT1F68WQ moderate Altered Expression [293]
ABCA13 OTTHTUQN Strong Biomarker [294]
ACADS OTGFANYQ Strong Biomarker [295]
ACP1 OTJ9CKLU Strong Genetic Variation [296]
ACTB OT1MCP2F Strong Biomarker [297]
ADAMTS16 OTTKUH99 Strong Genetic Variation [207]
ADCY3 OTGOQM6B Strong Biomarker [134]
ADCY9 OT1IZT5K Strong Genetic Variation [298]
ADD3 OTDRSHAZ Strong Biomarker [48]
AFG1L OTQ9VV5T Strong Genetic Variation [299]
AKAP10 OTPNFTOU Strong Biomarker [300]
AMPH OTWPGWZX Strong Biomarker [301]
ANKRD12 OTK16BL9 Strong Biomarker [302]
APOD OTT77XW8 Strong Biomarker [303]
ARHGEF10 OTHJ1Y4I Strong Biomarker [106]
ARHGEF5 OTUVGFT9 Strong Biomarker [304]
ARID3B OTUP9MS4 Strong Genetic Variation [305]
ASCC2 OT3B204T Strong Biomarker [35]
ASTN1 OT23FQIB Strong Biomarker [306]
ASTN2 OTF0W2FJ Strong Biomarker [131]
ATF5 OT03QCLM Strong Genetic Variation [307]
ATF7IP OTU6ZA7F Strong Genetic Variation [265]
BCL9 OTRBIPR4 Strong Biomarker [308]
BFAR OTTBG0V7 Strong Genetic Variation [309]
BHLHE40 OTITX14U Strong Biomarker [310]
BHLHE41 OTY9GJ1Y Strong Biomarker [222]
BID OTOSHSHU Strong Biomarker [311]
BIVM OTQEJWSA Strong Biomarker [312]
BPIFA2 OTLFSDZD Strong Biomarker [167]
BRAP OTB7BAFQ Strong Biomarker [313]
C14orf28 OTMAF0NU Strong Biomarker [194]
CACNB3 OTP30DIU Strong Biomarker [314]
CACNG5 OTN4PGI5 Strong Biomarker [98]
CALM2 OTNYA92F Strong Biomarker [315]
CAMK2A OTJGX19T Strong Biomarker [316]
CAMKMT OTLJBRUW Strong Genetic Variation [67]
CAP2 OTC1WFNO Strong Genetic Variation [317]
CARF OTWE0T6Q Strong Genetic Variation [318]
CAV2 OT1FGRQX Strong Genetic Variation [96]
CBLIF OTNE20WU Strong Biomarker [319]
CCDC170 OTNQOJ6S Strong Genetic Variation [318]
CDH17 OT9EV2XK Strong Biomarker [37]
CDH7 OTQEXCKU Strong Biomarker [320]
CDSN OTQW4HV6 Strong Altered Expression [321]
CEBPZ OT11BATG Strong Biomarker [322]
CHL1 OT6E6E8P Strong Genetic Variation [51]
CHRNA6 OTT6W86V Strong Biomarker [323]
CINP OTZ31XOT Strong Biomarker [324]
CKAP2L OT4T73GG Strong Genetic Variation [325]
CLEC10A OTD8HQT6 Strong Biomarker [326]
CLOCK OTNEOJY7 Strong Posttranslational Modification [327]
CNNM2 OTZHO8WU Strong Genetic Variation [166]
CNTN4 OTULXVE0 Strong Biomarker [328]
CNTN6 OTXVGVOR Strong Biomarker [279]
CNTNAP2 OT48T2ZP Strong Biomarker [131]
COMMD10 OT1ANQLQ Strong Genetic Variation [318]
COPE OTBKHBT7 Strong Biomarker [329]
CPLX1 OT7UIGTP Strong Biomarker [176]
CPLX2 OTU5QWFH Strong Biomarker [176]
CSRP1 OTUS7RM2 Strong Biomarker [330]
CYTH4 OTOR82ID Strong Biomarker [331]
DAZAP1 OTWLY0UE Strong Biomarker [332]
DBN1 OTZVKG8A Strong Biomarker [333]
DBNL OTT2OQOV Strong Biomarker [333]
DCTN5 OTESGJ1N Strong Biomarker [334]
DEFB1 OT5SV0E4 Strong Genetic Variation [335]
DGKB OTTT9SZJ Strong Biomarker [336]
DGKH OTYNPJ4B Strong Genetic Variation [76]
DHH OT3B7721 Strong Genetic Variation [337]
DIO2 OTGPNSLH Strong Biomarker [338]
DIXDC1 OT87DXEG Strong Biomarker [339]
DKK4 OTWCCVF6 Strong Biomarker [106]
DLG2 OTQ3BD8U Strong Biomarker [340]
DLG3 OTH591WK Strong Altered Expression [114]
DLX1 OT7BH057 Strong Altered Expression [341]
DLX4 OTLWVCN4 Strong Biomarker [118]
DMTF1 OTDKO9OO Strong Genetic Variation [342]
DNAH8 OTGES2OU Strong Biomarker [343]
DNTT OTFSEF12 Strong Biomarker [344]
DOCK4 OTH3XY8B Strong Genetic Variation [345]
DOCK9 OT84H8AD Strong Biomarker [346]
DOK5 OT2XWUPN Strong Biomarker [347]
DPYS OTLTUIVL Strong Genetic Variation [348]
DSCAM OTL7PRMK Strong Biomarker [349]
DTNBP1 OT9UQT2S Strong Altered Expression [350]
DTWD1 OT95QT6P Strong Biomarker [351]
DUSP2 OTH54FMR Strong Biomarker [75]
EHHADH OTBAAHL5 Strong Biomarker [153]
ENDOV OTX2GXXX Strong Genetic Variation [352]
ERVW-1 OTWV8DXJ Strong Biomarker [353]
ETNPPL OTSXO9P6 Strong Biomarker [354]
ETV5 OTE2OBM4 Strong Genetic Variation [58]
EVC OTRVYMXJ Strong Genetic Variation [355]
FBXL3 OTDQ1QKV Strong Biomarker [356]
FBXO32 OTUE978R Strong Genetic Variation [357]
FER1L6 OTII95GE Strong Genetic Variation [318]
FGF17 OTAQSFZ2 Strong Biomarker [106]
FGF20 OTJIQ8YZ Strong Biomarker [106]
FLAD1 OTY8R02L Strong Genetic Variation [169]
FNDC3A OTUX3S2I Strong Genetic Variation [358]
FSTL5 OT18C29S Strong Biomarker [48]
FXR1 OTEMQ1SR Strong Biomarker [359]
FZD4 OTGLZIE0 Strong Biomarker [360]
GABRB1 OT4L2SSB Strong Biomarker [361]
GABRB3 OT80C3D4 Strong Biomarker [129]
GABRG1 OT1NGUYY Strong Biomarker [130]
GADL1 OTJM4A0R Strong Altered Expression [362]
GDF10 OTEVXGJ7 Strong Altered Expression [231]
GLYAT OT3WWYXD Strong Biomarker [363]
GNAZ OTLTDTR8 Strong Genetic Variation [364]
GNB1L OTXSUD8R Strong Biomarker [365]
GNB3 OTA6HYBA Strong Biomarker [366]
GOLGA6A OTHU9MRX Strong Genetic Variation [367]
GPR78 OT8TKE6F Strong Biomarker [368]
GRID1 OTJ3WIKC Strong Biomarker [369]
GRIN3A OTQS9GYY Strong Biomarker [370]
GRIP1 OT958HK1 Strong Genetic Variation [192]
GRTP1 OT8HORRZ Strong Genetic Variation [318]
GTF2A1 OTWW4PN0 Strong Genetic Variation [174]
HBA1 OTW2BQF4 Strong Genetic Variation [144]
HIP1R OTIPKEJC Strong Biomarker [371]
HLA-DMB OT17HGXJ Strong Genetic Variation [250]
HLA-DRA OT7KZMP2 Strong Biomarker [372]
HLA-DRB4 OTNXIHQU Strong Biomarker [373]
HLA-E OTX1CTFB Strong Biomarker [374]
HMGXB4 OTB1QT9U Strong Genetic Variation [375]
HSPA1L OTC2V1K6 Strong Biomarker [174]
IDH3A OT5QQB5L Strong Biomarker [376]
IFNA1 OTPMKY0L Strong Biomarker [319]
IFT27 OT3NY6O6 Strong Biomarker [377]
IL17C OTKXIVNQ Strong Altered Expression [378]
IMPA1 OTBUVW1Z Strong Biomarker [379]
IMPACT OTQ923OB Strong Biomarker [380]
ITGA9 OTHN1IKA Strong Biomarker [381]
ITGB5 OT21MF51 Strong Genetic Variation [382]
ITIH1 OTSXJGQF Strong Biomarker [48]
ITIH3 OT4SLMLY Strong Genetic Variation [383]
ITIH4 OT460OO1 Strong Biomarker [206]
ITSN2 OT8S0OO8 Strong Altered Expression [384]
KANK4 OT5WC0Q8 Strong Genetic Variation [317]
KAT5 OTL7257A Strong Biomarker [385]
KCTD12 OTPYKT4Z Strong Biomarker [386]
KIF22 OTY6X6BL Strong Biomarker [387]
KLHL23 OT2UVSD2 Strong Genetic Variation [318]
LAMP3 OTN0XL3W Strong Genetic Variation [71]
LBX1 OTQJHICM Strong Biomarker [341]
LHX5 OT8DF1WF Strong Biomarker [388]
LITAF OTT5JX1F Strong Genetic Variation [389]
LMAN2L OTJ9FAWS Strong Biomarker [48]
LMX1A OTEEYD5L Strong Biomarker [390]
LRRC4C OT5QI5EP Strong Biomarker [391]
LRRC57 OTOXZQ4K Strong Altered Expression [392]
MAGEE1 OTOQQO2X Strong Biomarker [393]
MAGI1 OTMV4ASV Strong Biomarker [394]
MAGI2 OTXDDKZS Strong Biomarker [395]
MAP2 OT6UYT3X Strong Biomarker [396]
MAPK8IP3 OT0X8ACY Strong Biomarker [397]
MBD5 OTFHT4MO Strong Biomarker [398]
MCPH1 OTYT3TT5 Strong Genetic Variation [116]
ME2 OTO4LL76 Strong Biomarker [399]
MIXL1 OT584VOQ Strong Genetic Variation [400]
MKLN1 OTHMIMH6 Strong Biomarker [401]
MLLT3 OTXH4DDG Strong Biomarker [194]
MPPE1 OTINBJVE Strong Biomarker [402]
MRPS33 OTM44AZ1 Strong Biomarker [48]
MTA2 OTCCYIQJ Strong Genetic Variation [403]
MTERF4 OT50CTOJ Strong Genetic Variation [345]
MTHFD1 OTMKHVWC Strong Biomarker [168]
MUCL3 OTGAD3I0 Strong Genetic Variation [250]
MXD1 OTS5CTHX Strong Biomarker [404]
MYO5B OTCKL3W3 Strong Biomarker [405]
NANOS3 OTGX9IQU Strong Genetic Variation [406]
NCAN OT8OO6ZE Strong Biomarker [48]
ND1 OTCLGIXV Strong Altered Expression [407]
ND4 OT4RQVAA Strong Biomarker [407]
NDEL1 OTAGFML5 Strong Biomarker [408]
NDUFA6 OTEOIIOL Strong Biomarker [409]
NDUFS1 OTTIZDFR Strong Genetic Variation [410]
NDUFV1 OTEVK4WW Strong Genetic Variation [410]
NDUFV2 OTSZF7D6 Strong Genetic Variation [410]
NDUFV3 OTSCYB9P Strong Biomarker [183]
NEFL OTQESJV4 Strong Biomarker [340]
NEFM OT8VCBNF Strong Biomarker [106]
NEK4 OTOB8366 Strong Biomarker [206]
NFATC3 OTYOORME Strong Altered Expression [125]
NLGN1 OTGHRRFQ Strong Genetic Variation [69]
NOS1AP OTDFOBRU Strong Biomarker [411]
NPAS3 OT8D1ILB Strong Biomarker [412]
NPTX1 OTKVHCV0 Strong Biomarker [352]
NR2E1 OTW47GKM Strong Biomarker [413]
NRGN OTVGE10W Strong Genetic Variation [414]
NTNG1 OTF48IID Strong Altered Expression [415]
NUFIP2 OTZBZ224 Strong Genetic Variation [141]
OAS3 OT6E5FYS Strong Biomarker [35]
OBP2A OTBIJ5TI Strong Biomarker [387]
OPN5 OTCYGHDA Strong Genetic Variation [158]
OR10A4 OTYYB8SY Strong Genetic Variation [416]
OTUD7A OT3GCY98 Strong Genetic Variation [318]
OTX2 OTTV05B1 Strong Genetic Variation [417]
PACC1 OTKBS8CC Strong Biomarker [418]
PACS1 OT9TMQL3 Strong Biomarker [48]
PALB2 OT6DNDBG Strong Genetic Variation [59]
PARP9 OT7K4494 Strong Genetic Variation [419]
PC OT6O0V51 Strong Biomarker [48]
PCDH15 OTU9C2EH Strong Genetic Variation [318]
PCDH17 OTRK0M05 Strong Altered Expression [420]
PCDHA1 OT65E2NU Strong Genetic Variation [421]
PCLO OTXJZZ98 Strong Biomarker [422]
PCNT OTW4Z65J Strong Biomarker [423]
PDLIM4 OT23LZYY Strong Biomarker [330]
PENK OT8P3HMP Strong Biomarker [424]
PER3 OTVKYVJA Strong Genetic Variation [425]
PGAM1 OTZ5DB06 Strong Biomarker [426]
PHETA1 OT4IMC0X Strong Biomarker [427]
PIK3C3 OTLUM9L7 Strong Biomarker [428]
PIP4K2C OTHRWR93 Strong Biomarker [429]
PKP4 OTQHOF8L Strong Biomarker [430]
PLCXD3 OTJNSWMU Strong Biomarker [431]
PLEKHO1 OTMVUQ9W Strong Biomarker [48]
PMCH OT3D9SA4 Strong Biomarker [432]
POGLUT2 OT5G79NO Strong Biomarker [312]
POLG OTDUCT04 Strong CausalMutation [433]
POU3F1 OTYARA94 Strong Biomarker [434]
POU3F2 OT30NFOC Strong Biomarker [435]
PPIE OTIE5OAD Strong Posttranslational Modification [436]
PPM1K OTNZ4N4E Strong Genetic Variation [305]
PPP1R1B OTSIJMQ9 Strong Altered Expression [437]
PPP1R9A OTJL2TOC Strong Biomarker [161]
PPP2R2C OTXK0SDM Strong Biomarker [196]
PPP3CB OTEGNEHW Strong Biomarker [438]
PPP3CC OT0AQD93 Strong Biomarker [106]
PROK2 OT70IFEZ Strong Biomarker [191]
PSD OTUZIXUZ Strong Biomarker [114]
PSMG1 OTZ5I6UM Strong Biomarker [75]
PSPH OTV1PVAX Strong Biomarker [167]
PTOV1 OT94WT5X Strong Biomarker [439]
PTPN5 OT2H1KDK Strong Altered Expression [440]
PVALB OTZW1WVQ Strong Altered Expression [441]
RAPGEF5 OT53VS75 Strong Biomarker [442]
RAPSN OTGMSWDQ Strong Genetic Variation [169]
RARRES2 OT1BJE8K Strong Genetic Variation [192]
RASGRF1 OTNWJ7EN Strong Biomarker [442]
RASGRF2 OT67DAGF Strong Genetic Variation [443]
RBM3 OTAJ7R31 Strong Biomarker [444]
RCBTB1 OTAYELI8 Strong Genetic Variation [367]
RELN OTLKMW1O Strong Altered Expression [445]
REM1 OTUXL0HC Strong Biomarker [446]
RERE OT3G4GBZ Strong Genetic Variation [250]
RFESD OTLYAJIB Strong Genetic Variation [345]
RIDA OTW4098I Strong Biomarker [167]
RIMS1 OT10T7CK Strong Biomarker [48]
RIT2 OTSNYG0D Strong Genetic Variation [447]
RNF41 OTN1DQOY Strong Altered Expression [448]
RPGRIP1L OT6Z069I Strong Genetic Variation [59]
RPL29 OTUFIBJL Strong Biomarker [449]
RPRD2 OTPPH601 Strong Genetic Variation [383]
RPS23 OTAJMUPF Strong Altered Expression [450]
S100A11 OTI57KDN Strong Altered Expression [198]
SART3 OTC1AM7S Strong Biomarker [35]
SEC11A OT06L834 Strong Genetic Variation [443]
SEC24C OTMTJBQ1 Strong Biomarker [451]
SEPTIN11 OTX2O0ZX Strong Biomarker [452]
SESTD1 OTHH06X8 Strong Genetic Variation [71]
SEZ6L OT5Z9CUA Strong Biomarker [453]
SFRP1 OT0U9G41 Strong Biomarker [106]
SFTA2 OTVRIUIV Strong Genetic Variation [250]
SHANK2 OTSQTPFQ Strong Biomarker [48]
SHC4 OTQ0H76H Strong Biomarker [454]
SLITRK2 OTPVI22J Strong Biomarker [455]
SMS OT8JYKNH Strong Biomarker [436]
SND1 OTT734JN Strong Biomarker [35]
SNED1 OTBQVXY5 Strong Genetic Variation [345]
SOCS5 OTN1ABYR Strong Altered Expression [456]
SORL1 OTQ8FFNS Strong Biomarker [457]
SOSTDC1 OTAKDNSM Strong Biomarker [458]
SP4 OTWB30IZ Strong Genetic Variation [48]
SP8 OTLCMPKH Strong Biomarker [459]
SRRT OTMYPSWV Strong Biomarker [451]
SRSF3 OTOFT707 Strong Biomarker [460]
SS18L1 OT9ZEGV7 Strong Biomarker [461]
SSBP2 OTYG1G80 Strong Biomarker [48]
ST13 OTNML6UP Strong Biomarker [449]
ST3GAL1 OTFCO8QX Strong Biomarker [462]
ST3GAL3 OTOORKUE Strong Biomarker [171]
ST8SIA2 OTRBBBD8 Strong Genetic Variation [463]
STARD9 OTZ5CIXU Strong Genetic Variation [48]
STT3A OTDPS6AV Strong Genetic Variation [250]
STXBP3 OTTTYMAQ Strong Biomarker [167]
SVEP1 OTOBICRD Strong Genetic Variation [464]
SYN3 OTSGYNA5 Strong Genetic Variation [465]
TAC1 OTM842YW Strong Biomarker [466]
TAF15 OTNE038N Strong Biomarker [174]
TBC1D22A OTP3JJLW Strong Genetic Variation [268]
THSD7A OT7249HH Strong Biomarker [48]
TLL2 OTHZ4TBL Strong Biomarker [467]
TMPRSS13 OTMAOAP3 Strong Biomarker [468]
TMSB10 OTLVZ13T Strong Biomarker [469]
TOM1 OT30QA56 Strong Genetic Variation [375]
TPI1 OT14KP4B Strong Biomarker [304]
TPSG1 OTDESHKT Strong Genetic Variation [470]
TRIM26 OTS0DJIP Strong Genetic Variation [250]
TSHB OTFDI39D Strong Biomarker [471]
TSNAX OTZ9SGWB Strong Biomarker [472]
ADCY8 OTR1WCZX Definitive Biomarker [473]
ANKK1 OT0OM1O0 Definitive Biomarker [474]
BAG1 OTRQNIA4 Definitive Biomarker [475]
BCR OTCN76C1 Definitive Genetic Variation [476]
CHRNB3 OTE5XENW Definitive Biomarker [477]
CUX2 OTDJTQAJ Definitive Biomarker [427]
EGR2 OTAVQ78J Definitive Biomarker [478]
EGR3 OTGPJIRA Definitive Biomarker [479]
FABP7 OTRE2H4G Definitive Biomarker [480]
GNAL OTESDTEU Definitive Altered Expression [481]
HSPA4 OT5HR0AR Definitive Altered Expression [482]
MDGA1 OTVXEF85 Definitive Biomarker [199]
NAPG OTY4WS64 Definitive Biomarker [483]
NCS1 OT6JHAWM Definitive Biomarker [484]
NDST3 OT8TWYOG Definitive Biomarker [485]
NPAS2 OTMRT2TS Definitive Biomarker [486]
NRXN1 OTJN1JQA Definitive Biomarker [63]
PER2 OTU2B1DJ Definitive Biomarker [314]
PFKL OTVHGAT7 Definitive Genetic Variation [487]
PGP OT6QQ7OR Definitive Biomarker [488]
PTPA OTRGFOI7 Definitive Altered Expression [489]
RASGRP1 OTX9WN2E Definitive Biomarker [180]
RFX4 OTYFRHPA Definitive Biomarker [490]
SORCS2 OTBF3DYK Definitive Biomarker [63]
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References

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2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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5 Ketamine FDA Label
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8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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12 Ziprasidone FDA Label
13 Zonisamide FDA Label
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249 Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder.Eur Neuropsychopharmacol. 2012 Sep;22(9):632-40. doi: 10.1016/j.euroneuro.2012.01.007. Epub 2012 Feb 21.
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316 Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder.J Psychiatr Res. 2019 Aug;115:165-175. doi: 10.1016/j.jpsychires.2019.05.024. Epub 2019 May 25.
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318 GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores.Am J Psychiatry. 2019 Aug 1;176(8):651-660. doi: 10.1176/appi.ajp.2019.18080957. Epub 2019 Jun 5.
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320 Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population.Behav Genet. 2014 Mar;44(2):97-101. doi: 10.1007/s10519-014-9645-y. Epub 2014 Feb 20.
321 Stimulatory G-protein alpha-subunit mRNA levels are not increased in autopsied cerebral cortex from patients with bipolar disorder.Brain Res Mol Brain Res. 1996 Nov;42(1):45-50. doi: 10.1016/s0169-328x(96)00112-x.
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326 Influence of antipsychotic drugs on human endogenous retrovirus (HERV) transcription in brain cells.PLoS One. 2012;7(1):e30054. doi: 10.1371/journal.pone.0030054. Epub 2012 Jan 11.
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332 Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring.PLoS One. 2013;8(2):e56967. doi: 10.1371/journal.pone.0056967. Epub 2013 Feb 22.
333 Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients.Transl Psychiatry. 2012 Jul 3;2(7):e132. doi: 10.1038/tp.2012.55.
334 Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro.Mol Cell Neurosci. 2011 Jun;47(2):93-9. doi: 10.1016/j.mcn.2010.12.014. Epub 2011 Mar 30.
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336 Diacylglycerol kinase knockout mice exhibit lithium-sensitive behavioral abnormalities.PLoS One. 2010 Oct 18;5(10):e13447. doi: 10.1371/journal.pone.0013447.
337 A genetic variant in 12q13, a possible risk factor for bipolar disorder, is associated with depressive state, accounting for stressful life events.PLoS One. 2014 Dec 17;9(12):e115135. doi: 10.1371/journal.pone.0115135. eCollection 2014.
338 Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population.Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 31;33(6):986-90. doi: 10.1016/j.pnpbp.2009.05.003. Epub 2009 May 7.
339 DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/-catenin signaling.Mol Psychiatry. 2018 Feb;23(2):467-475. doi: 10.1038/mp.2016.184. Epub 2016 Oct 18.
340 Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder.Brain Res. 2007 Jan 5;1127(1):108-18. doi: 10.1016/j.brainres.2006.09.011. Epub 2006 Nov 17.
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349 Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder.Psychiatr Genet. 2008 Feb;18(1):1-10. doi: 10.1097/YPG.0b013e3281ac238e.
350 Antipsychotic drugs attenuate aberrant DNA methylation of DTNBP1 (dysbindin) promoter in saliva and post-mortem brain of patients with schizophrenia and Psychotic bipolar disorder.Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):687-96. doi: 10.1002/ajmg.b.32361. Epub 2015 Aug 18.
351 Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder.Eur Neuropsychopharmacol. 2019 Jan;29(1):156-170. doi: 10.1016/j.euroneuro.2018.10.005. Epub 2018 Nov 29.
352 Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.Bipolar Disord. 2015 Mar;17(2):205-11. doi: 10.1111/bdi.12239. Epub 2014 Jul 23.
353 Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder.Transl Psychiatry. 2012 Dec 4;2(12):e201. doi: 10.1038/tp.2012.125.
354 Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.J Biol Chem. 2012 Mar 2;287(10):7246-55. doi: 10.1074/jbc.M111.323485. Epub 2012 Jan 12.
355 Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.Mol Psychiatry. 2015 Oct;20(10):1212-8. doi: 10.1038/mp.2014.118. Epub 2014 Oct 14.
356 Reduced anxiety and depression-like behaviours in the circadian period mutant mouse afterhours.PLoS One. 2012;7(6):e38263. doi: 10.1371/journal.pone.0038263. Epub 2012 Jun 15.
357 Fine-mapping scan of bipolar disorder susceptibility loci in Latino pedigrees.Am J Med Genet B Neuropsychiatr Genet. 2019 Apr;180(3):213-222. doi: 10.1002/ajmg.b.32715. Epub 2019 Feb 19.
358 Association analysis of the dopamine transporter (DAT1)-67A/T polymorphism in bipolar disorder.Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):47-9. doi: 10.1002/ajmg.b.30174.
359 Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3 Are Modulators of Anxiety and Glutamatergic Neurotransmission.Front Mol Neurosci. 2018 Apr 12;11:119. doi: 10.3389/fnmol.2018.00119. eCollection 2018.
360 Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.Mol Psychiatry. 2005 May;10(5):470-8. doi: 10.1038/sj.mp.4001593.
361 Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.Mol Psychiatry. 2010 Feb;15(2):146-53. doi: 10.1038/mp.2008.66. Epub 2008 Jul 1.
362 Lithium response in bipolar disorder: No difference in GADL1 gene expression between cell lines from excellent-responders and non-responders.Psychiatry Res. 2017 May;251:217-220. doi: 10.1016/j.psychres.2017.02.022. Epub 2017 Feb 14.
363 Polymorphisms and haplotypes in the YWHAE gene increase susceptibility to bipolar disorder in Chinese Han population.J Clin Psychiatry. 2012 Oct;73(10):e1276-82. doi: 10.4088/JCP.12m07824.
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366 C825T polymorphism of the GNB3 gene on valproate-related metabolic abnormalities in bipolar disorder patients.J Clin Psychopharmacol. 2010 Oct;30(5):512-7. doi: 10.1097/JCP.0b013e3181f03f50.
367 Targeted lipidomics reveal derangement of ceramides in major depression and bipolar disorder.Metabolism. 2019 Jun;95:65-76. doi: 10.1016/j.metabol.2019.04.002. Epub 2019 Apr 5.
368 Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia.Mol Psychiatry. 2006 Apr;11(4):384-94. doi: 10.1038/sj.mp.4001786.
369 Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.PLoS One. 2012;7(3):e32969. doi: 10.1371/journal.pone.0032969. Epub 2012 Mar 7.
370 NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder.Schizophr Res. 2004 Dec 1;71(2-3):361-70. doi: 10.1016/j.schres.2004.02.016.
371 Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: implications for oligodendrocyte viability.Neurochem Int. 2007 Feb;50(3):461-90. doi: 10.1016/j.neuint.2006.11.009. Epub 2007 Jan 18.
372 Genes involved in pruning and inflammation are enriched in a large mega-sample of patients affected by Schizophrenia and Bipolar Disorder and controls.Psychiatry Res. 2015 Aug 30;228(3):945-9. doi: 10.1016/j.psychres.2015.06.013. Epub 2015 Jun 26.
373 Human leukocyte antigen alleles in patients with bipolar disorder in the Korean population.Psychiatry Clin Neurosci. 2002 Aug;56(4):453-7. doi: 10.1046/j.1440-1819.2002.01035.x.
374 Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries.Hum Mol Genet. 2011 Jan 15;20(2):387-91. doi: 10.1093/hmg/ddq471. Epub 2010 Oct 29.
375 Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1.Am J Med Genet B Neuropsychiatr Genet. 2008 Jan 5;147B(1):59-67. doi: 10.1002/ajmg.b.30574.
376 Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.Mol Psychiatry. 2016 Nov;21(11):1504-1510. doi: 10.1038/mp.2015.217. Epub 2016 Jan 19.
377 Evidence for association of bipolar disorder to haplotypes in the 22q12.3 region near the genes stargazin, IFT27 and parvalbumin.Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):941-50. doi: 10.1002/ajmg.b.32099. Epub 2012 Oct 4.
378 Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs.Mol Psychiatry. 2000 Jul;5(4):425-32. doi: 10.1038/sj.mp.4000741.
379 A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability. Mol Psychiatry. 2016 Aug;21(8):1125-9. doi: 10.1038/mp.2015.150. Epub 2015 Sep 29.
380 Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder.Mol Psychiatry. 2001 Jan;6(1):87-91. doi: 10.1038/sj.mp.4000799.
381 Refinement of chromosome 3p22.3 region and identification of a susceptibility gene for bipolar affective disorder.Am J Med Genet B Neuropsychiatr Genet. 2013 Mar;162B(2):163-8. doi: 10.1002/ajmg.b.32127. Epub 2012 Dec 31.
382 A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds.Eur J Hum Genet. 2020 Apr;28(4):499-507. doi: 10.1038/s41431-019-0526-y. Epub 2019 Nov 6.
383 Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression.Mol Psychiatry. 2020 Jul;25(7):1420-1429. doi: 10.1038/s41380-018-0336-6. Epub 2019 Jan 9.
384 You'll feel better in the morning: slow wave activity and overnight mood regulation in interepisode bipolar disorder.Psychol Med. 2018 Jan;48(2):249-260. doi: 10.1017/S0033291717001581. Epub 2017 Jun 19.
385 Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients.Mol Psychiatry. 2011 Apr;16(4):419-28. doi: 10.1038/mp.2009.137. Epub 2009 Dec 29.
386 Altered emotionality and neuronal excitability in mice lacking KCTD12, an auxiliary subunit of GABAB receptors associated with mood disorders.Transl Psychiatry. 2015 Feb 17;5(2):e510. doi: 10.1038/tp.2015.8.
387 White matter - emotion processing activity relationships in youth offspring of bipolar parents.J Affect Disord. 2019 Jan 15;243:153-164. doi: 10.1016/j.jad.2018.09.010. Epub 2018 Sep 11.
388 Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5.Psychiatr Genet. 2003 Jun;13(2):97-101. doi: 10.1097/01.ypg.0000057882.80011.9e.
389 Is a SIMPLe smartphone application capable of improving biological rhythms in bipolar disorder?.J Affect Disord. 2017 Dec 1;223:10-16. doi: 10.1016/j.jad.2017.07.028. Epub 2017 Jul 10.
390 Polymorphisms of dopamine pathway genes NRG1 and LMX1A are associated with cognitive performance in bipolar disorder.Bipolar Disord. 2015 Dec;17(8):859-68. doi: 10.1111/bdi.12347. Epub 2015 Nov 3.
391 NGL-1/LRRC4C-Mutant Mice Display Hyperactivity and Anxiolytic-Like Behavior Associated With Widespread Suppression of Neuronal Activity.Front Mol Neurosci. 2019 Oct 11;12:250. doi: 10.3389/fnmol.2019.00250. eCollection 2019.
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393 Increased DNA and RNA damage by oxidation in patients with bipolar I disorder.Transl Psychiatry. 2016 Aug 9;6(8):e867. doi: 10.1038/tp.2016.141.
394 Investigating the genetic variation underlying episodicity in major depressive disorder: suggestive evidence for a bipolar contribution.J Affect Disord. 2014 Feb;155:81-9. doi: 10.1016/j.jad.2013.10.027. Epub 2013 Oct 29.
395 MAGI1 copy number variation in bipolar affective disorder and schizophrenia.Biol Psychiatry. 2012 May 15;71(10):922-30. doi: 10.1016/j.biopsych.2012.01.020. Epub 2012 Feb 28.
396 Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines.Am J Psychiatry. 2004 Oct;161(10):1848-55. doi: 10.1176/ajp.161.10.1848.
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398 Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities.Mol Psychiatry. 2014 Mar;19(3):368-79. doi: 10.1038/mp.2013.42. Epub 2013 Apr 16.
399 Malic enzyme 2 and susceptibility to psychosis and mania.Psychiatry Res. 2007 Feb 28;150(1):1-11. doi: 10.1016/j.psychres.2006.06.001. Epub 2007 Jan 29.
400 Aggressiveness in depression: a neglected symptom possibly associated with bipolarity and mixed features.Acta Psychiatr Scand. 2017 Oct;136(4):362-372. doi: 10.1111/acps.12777. Epub 2017 Jul 25.
401 A genome wide association study suggests the association of muskelin with early onset bipolar disorder: Implications for a GABAergic epileptogenic neurogenesis model.J Affect Disord. 2017 Jan 15;208:120-129. doi: 10.1016/j.jad.2016.09.049. Epub 2016 Sep 30.
402 Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder.Am J Med Genet B Neuropsychiatr Genet. 2010 Apr 5;153B(3):830-6. doi: 10.1002/ajmg.b.31042.
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405 Myosin Vb gene is associated with schizophrenia in Chinese Han population.Psychiatry Res. 2013 May 15;207(1-2):13-8. doi: 10.1016/j.psychres.2013.02.026. Epub 2013 Apr 3.
406 A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder.Int J Neuropsychopharmacol. 2006 Feb;9(1):13-20. doi: 10.1017/S1461145705005560. Epub 2005 Jun 21.
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409 Decreased AKT1/mTOR pathway mRNA expression in short-term bipolar disorder.Eur Neuropsychopharmacol. 2015 Apr;25(4):468-73. doi: 10.1016/j.euroneuro.2015.02.002. Epub 2015 Feb 16.
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415 Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.Neuropsychopharmacology. 2008 Mar;33(4):933-45. doi: 10.1038/sj.npp.1301457. Epub 2007 May 16.
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