General Information of Drug (ID: DMKA7H3)

Drug Name
Cresemba
Synonyms
Isavuconazonium sulfate; 946075-13-4; BAL-8557-002; Isavuconazonium sulfate [USAN]; CHEBI:85977; Isavuconazonium sulfate (USAN); UNII-31Q44514JV; BAL8557-002; 31Q44514JV; CHEMBL3137333; MolPort-044-559-915; AKOS030527357; Glycine, N-methyl-, (2-(((1-(1-((2R,3R)-3-(4-(4-cyanophenyl)-2-thiazolyl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4H-1,2,4-triazolium-4-yl)ethoxy)carbonyl)methylamino)-3-pyridinyl)methyl ester, sulfate (1:1); AS-35043; SC-12899; 1-((2R,3R)-3-(4-(4-Cyanophenyl)-1,3-thiazol-2-yl)-2-(2,5-difluorophe
Indication
Disease Entry ICD 11 Status REF
Invasive aspergillosis 1F20.0 Phase 3 [1]
Haematological malignancy 2B33.Y Phase 1 [2]
Structure
3D MOL 2D MOL
Chemical Identifiers
Formula
C35H36F2N8O9S2
Canonical SMILES
CC(C1=NC(=CS1)C2=CC=C(C=C2)C#N)C(CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O.OS(=O)(=O)[O-]
InChI
1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
InChIKey
LWXUIUUOMSMZKJ-KLFWAVJMSA-M
Cross-matching ID
PubChem CID
72196309
ChEBI ID
CHEBI:85977
CAS Number
946075-13-4
TTD ID
D0DD4P
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

References

1 ClinicalTrials.gov (NCT03471988) Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)