Details of Disease

General Information of Disease (ID: DISAI029)

• Disease Name: Invasive aspergillosis
• Disease Class: 1F20: Aspergillosis
• Definition: An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.
• Disease Hierarchy:
  DISCZVAA: Pulmonary aspergilloma
  DISAI029: Invasive aspergillosis
• ICD Code:
  ICD-11: ICD-11: 1F20.0
  ICD-10: ICD-10: B44.0, B44.8
  ICD-9: ICD-9: 117.3
  Expand ICD-11: '1F20.0
  Expand ICD-10: 'B44.0; 'B44.8
  Expand ICD-9: 117.3
• Disease Identifiers:
  MONDO ID: MONDO_0000240
  UMLS CUI: C0238013
  MedGen ID: 922866
  SNOMED CT ID: 721798004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Micafungin	DM6Y3AN	Approved	Small molecular drug	[1]
Voriconazole	DMAOL2S	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cresemba	DMKA7H3	Phase 3	NA	[3]
Isavuconazole	DMSV12M	Phase 3	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CEL	TTTRNQW	Limited	Biomarker	[5]
SCT	TTOBVIN	Limited	Biomarker	[6]
CDC37	TT5SOEU	Strong	Biomarker	[7]
CYP51A1	TT67TDP	Strong	Genetic Variation	[8]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC27A5	DT0TQS3	Limited	Biomarker	[5]

This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLEC7A	OTRTBH27	Limited	Genetic Variation	[9]
ETFA	OTXX61VZ	Limited	Biomarker	[10]
PARP9	OT7K4494	Limited	Biomarker	[5]
CARTPT	OTTE4V9S	Strong	Genetic Variation	[11]
FBXO15	OTJHEFE5	Strong	Altered Expression	[12]
KAT2A	OTN0W2SW	Strong	Biomarker	[13]
MAEA	OTPA2FDE	Strong	Biomarker	[14]
PTX3	OTPXHRKU	Strong	Genetic Variation	[15]
SPTA1	OT1YMP65	Strong	Biomarker	[16]

References

• [1] Micafungin FDA Label
• [2] Disk diffusion test and E-test with enriched Mueller-Hinton agar for determining susceptibility of Candida species to voriconazole and fluconazole. J Microbiol Immunol Infect. 2009 Apr;42(2):148-53.
• [3] ClinicalTrials.gov (NCT03471988) Clinical Study of AK1820 (Isavuconazonium Sulfate) for the Treatment of Deep Mycosis. U.S. National Institutes of Health.
• [4] ClinicalTrials.gov (NCT00634049) Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi. U.S. National Institutes of Health.
• [5] Performance of the AsperGenius PCR assay for detecting azole resistant Aspergillus fumigatus in BAL fluids from allogeneic HSCT recipients: A prospective cohort study from Essen, West Germany.Med Mycol. 2020 Feb 1;58(2):268-271. doi: 10.1093/mmy/myz050.
• [6] Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes.Curr Res Transl Med. 2017 Apr-Jun;65(2):77-81. doi: 10.1016/j.retram.2017.05.003. Epub 2017 Jul 5.
• [7] Serum IgG responses against Aspergillus proteins before hematopoietic stem cell transplantation or chemotherapy identify patients who develop invasive aspergillosis.Biol Blood Marrow Transplant. 2012 Dec;18(12):1927-34. doi: 10.1016/j.bbmt.2012.07.013. Epub 2012 Jul 21.
• [8] Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013.PLoS One. 2014 Jul 29;9(7):e103113. doi: 10.1371/journal.pone.0103113. eCollection 2014.
• [9] Association between polymorphisms in the genes encoding toll-like receptors and dectin-1 and susceptibility to invasive aspergillosis: a systematic review.Rev Soc Bras Med Trop. 2018 Nov-Dec;51(6):725-730. doi: 10.1590/0037-8682-0314-2018.
• [10] Isavuconazole: A new broad-spectrum azole. Part 2: pharmacokinetics and clinical activity.J Mycol Med. 2018 Mar;28(1):15-22. doi: 10.1016/j.mycmed.2018.02.002. Epub 2018 Mar 16.
• [11] Value of serial quantification of fungal DNA by a real-time PCR-based technique for early diagnosis of invasive Aspergillosis in patients with febrile neutropenia.J Clin Microbiol. 2009 Feb;47(2):379-84. doi: 10.1128/JCM.01716-08. Epub 2008 Dec 24.
• [12] SCF Ubiquitin Ligase F-box Protein Fbx15 Controls Nuclear Co-repressor Localization, Stress Response and Virulence of the Human Pathogen Aspergillus fumigatus.PLoS Pathog. 2016 Sep 20;12(9):e1005899. doi: 10.1371/journal.ppat.1005899. eCollection 2016 Sep.
• [13] The histone acetyltransferase GcnE regulates conidiation and biofilm formation in Aspergillus fumigatus.Med Mycol. 2020 Feb 1;58(2):248-259. doi: 10.1093/mmy/myz043.
• [14] Treating invasive aspergillosis in patients with hematologic malignancy: diagnostic-driven approach versus empiric therapies.BMC Infect Dis. 2018 Dec 13;18(1):656. doi: 10.1186/s12879-018-3584-9.
• [15] Pentraxin 3 Gene Polymorphisms and Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Patients.Clin Infect Dis. 2018 Jan 6;66(2):261-267. doi: 10.1093/cid/cix749.
• [16] Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases.J Biol Chem. 2019 Jul 12;294(28):10760-10772. doi: 10.1074/jbc.RA119.008511. Epub 2019 Jun 5.