Details of the Drug

General Information of Drug (ID: DMKMCP8)

Drug Name

LEO 43204

Synonyms

ingenol disoxate; Ingenol disoxate; UNII-3B100VJ4ZW; 3B100VJ4ZW; 1383547-60-1; Ingenol disoxate [INN]; Ingenol disoxate [USAN:INN]; SCHEMBL16153426; CHEMBL3989918; LEO43204; 4-Isoxazolecarboxylic acid, 3,5-diethyl-, (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta(a)cyclopropa(E)cyclodecen-6-yl ester

Indication

Disease Entry	ICD 11	Status	REF
Squamous cell carcinoma	2B60-2D01	Phase 3	[1]
Acne vulgaris	ED80	Phase 2	[2]
Actinic keratosis	EK90.0	Phase 2	[2]
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Structure

3D MOL

2D MOL

Chemical Identifiers

Formula: C28H37NO7
Canonical SMILES: CCC1=C(C(=NO1)CC)C(=O)OC2C(=CC34C2(C(C(=CC(C3=O)C5C(C5(C)C)CC4C)CO)O)O)C
InChI: 1S/C28H37NO7/c1-7-18-20(19(8-2)36-29-18)25(33)35-24-13(3)11-27-14(4)9-17-21(26(17,5)6)16(23(27)32)10-15(12-30)22(31)28(24,27)34/h10-11,14,16-17,21-22,24,30-31,34H,7-9,12H2,1-6H3/t14-,16+,17-,21+,22-,24+,27+,28+/m1/s1
InChIKey: GLIUZQUNUNICGS-XUBYYPQFSA-N

Cross-matching ID

PubChem CID: 57410862
CAS Number: 1383547-60-1
TTD ID: D02ZZG

Repurposed Drugs (RPD)

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)