Details of the Drug

General Information of Drug (ID: DMKP3SJ)

Drug Name

F-351

Synonyms

Liver cirrhosis, Gene Networks International; Liver cirrhosis, Shanghai; Liver fibrosis therapy, Shanghai Genomics; Liver fibrosis, Gene Networks International; Liver fibrosis, Shanghai

Indication

Disease Entry	ICD 11	Status	REF
Liver disease	DB90-BD99	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

201.22

Logarithm of the Partition Coefficient (xlogp)

1.5

Rotatable Bond Count (rotbonds)

1

Hydrogen Bond Donor Count (hbonddonor)

1

Hydrogen Bond Acceptor Count (hbondacc)

2

Chemical Identifiers

Formula: C12H11NO2
IUPAC Name: 1-(4-hydroxyphenyl)-5-methylpyridin-2-one
Canonical SMILES: CC1=CN(C(=O)C=C1)C2=CC=C(C=C2)O
InChI: InChI=1S/C12H11NO2/c1-9-2-7-12(15)13(8-9)10-3-5-11(14)6-4-10/h2-8,14H,1H3
InChIKey: NETTXQJYJRFTFS-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 11217901
CAS Number: 851518-71-3
TTD ID: D00AKV

Combinatorial Drugs (CBD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aminotransferase (AT)	TTRAXK5	NOUNIPROTAC	Inhibitor	[2]

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Molecular Interaction Atlas (MIA)

MIA Detail

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020436)
2	Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus. J Bacteriol. 2000 Jul;182(14):4087-95.