Details of Disease

General Information of Disease (ID: DIS2OMMF)

Disease Name	Liver disease
Synonyms	liver disease or disorder; disease or disorder of liver; liver and intrahepatic bile duct disorder; liver disease; liver disorder; disease of liver; hepatic disorder; disorder of liver; hepatic disease
Disease Class	DB90-DB9Z: Liver disease
Definition	A disease involving the liver.
Disease Hierarchy	DISRGY2N: Endocrine disease DISEW817: Hepatobiliary disorder DISWD40R: Disease DIS2OMMF: Liver disease
ICD Code	ICD-11 ICD-11: DB90-BD99 Expand ICD-11 'DB9Z Expand ICD-10 'K70-K77; 'K77; 'K77.0; 'K77.8 Expand ICD-9 5.71E+14
Disease Identifiers	MONDO ID MONDO_0005154 UMLS CUI C4021780 MedGen ID 893061 HPO ID HP:0001392

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetylcysteine	DMWSXI4	Approved	Small molecular drug	[1]
BAY-86-4884	DMTGJQ2	Approved	NA	[1]
Ferumoxides	DMIWY08	Approved	Small molecular drug	[1]
Lactitol	DMEDMTJ	Approved	Small molecular drug	[1]
Lusutrombopag	DMH6IKO	Approved	NA	[2]
Silyman DD	DML7G8G	Approved	NA	[1]
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This Disease is Treated as An Indication in 8 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ASP1941	DMGQ1TV	Phase 3	Small molecular drug	[3]
DDB-S	DMA7296	Phase 2	NA	[4]
F-351	DMKP3SJ	Phase 2	Small molecular drug	[5]
IdB-1016	DMPREQF	Phase 2	NA	[6]
PF-04457845	DMPRYU1	Phase 2	Small molecular drug	[7]
Picroliv	DMT9OEZ	Phase 2	NA	[8]
Cryopreserved human liver cells	DMJ1OVW	Phase 1	NA	[9]
Hepapoietin	DMM7VOB	Phase 1	NA	[10]
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⏷ Show the Full List of 8 Drug(s)

This Disease is Treated as An Indication in 3 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LIMAZOCIC	DM4X385	Discontinued in Phase 2	Small molecular drug	[11]
AMI-HS	DMAJP97	Discontinued in Phase 1	NA	[12]
DV-7021	DM19U50	Terminated	NA	[13]
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This Disease is Treated as An Indication in 6 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Cirrhosis	DMQPXQX	Investigative	NA	[14]
GAI-122	DMUWVOS	Investigative	NA	[14]
Human embryonic stem cell-derived hepatocytes	DMG4HGD	Investigative	NA	[14]
Human liver-engrafting cells	DMGI23B	Investigative	NA	[14]
JKB-119	DMLAZBI	Investigative	NA	[14]
PP-202	DMOEOSY	Investigative	NA	[14]
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⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SERPINA1	TTA7UJC	Strong	CausalMutation	[15]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCDC47	OTUIN61P	Strong	Biomarker	[16]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	ClinicalTrials.gov (NCT01054443) A Study to Investigate the Efficacy and Safety of S-888711 Tablets Administered to Adult Subjects With Immune Thrombocytopenia (ITP). U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT01054092) A Study to Assess the Long-term Safety and Efficacy of ASP1941 in Japanese Diabetic Patients. U.S. National Institutes of Health.
4	Comparative Hepatitis, Olaf Weber, lrike Protzer. Page(370).
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020436)
6	ClinicalTrials.gov (NCT00443079) A Study of Siliphos in Adults With Non-alcoholic Steatohepatitis (NASH). U.S. National Institutes of Health.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6694).
8	Clinical pipeline report, company report or official report of CSIR-Central Drug Research Institute.
9	Clinical pipeline report, company report or official report of Vesta Therapeutics.
10	Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. Aliment Pharmacol Ther. 2002 Feb;16(2):235-42.
11	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003050)
12	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005766)
13	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005272)
14	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
15	The deficient alpha-I-antitrypsin phenotype PI P is associated with an A-to-T transversion in exon III of the gene.Am J Hum Genet. 1989 Jul;45(1):161-3.
16	Bi-allelic CCDC47 Variants Cause a Disorder Characterized by Woolly Hair, Liver Dysfunction, Dysmorphic Features, and Global Developmental Delay. Am J Hum Genet. 2018 Nov 1;103(5):794-807. doi: 10.1016/j.ajhg.2018.09.014. Epub 2018 Oct 25.