Details of the Drug

General Information of Drug (ID: DMMC4BY)

• Drug Name: Brominide tartrate
• Synonyms: BRIMONIDINE TARTRATE; 70359-46-5; Brimonidine tartarate; Alphagan; Brimonidine D-tartrate; UNII-4S9CL2DY2H; Brimonidinne tartrate; C11H10BrN5.C4H6O6; Brimonidine L-Tartrate; Brimonidine (tartrate); Brimonidine D-tartarate; 79570-19-7; 4S9CL2DY2H; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine (2R,3R)-2,3-dihydroxysuccinate; UK-14304-18; Qoliana; brimonidine Purite; Brimonidine tartrate [USAN]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 1:
  Molecular Weight; 442.22
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 5
  Hydrogen Bond Donor Count; 6
  Hydrogen Bond Acceptor Count; 9
• Chemical Identifiers:
  Formula: C15H16BrN5O6
  IUPAC Name: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine;(2R,3R)-2,3-dihydroxybutanedioic acid
  Canonical SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O
  InChI: InChI=1S/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
  InChIKey: QZHBYNSSDLTCRG-LREBCSMRSA-N
• Cross-matching ID:
  PubChem CID: 54405
  CAS Number: 70359-46-5
  TTD ID: D00ARM
  ACDINA ID: D00893

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor Alpha-2 (ADRA2)	TTQ8AFT	NOUNIPROTAC	Agonist	[1]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Kyselina citronova	E00014	311	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Potassium chloride	E00074	4873	Tonicity agent
Sodium citrate anhydrous	E00102	6224	Alkalizing agent; Buffering agent; Complexing agent; Emulsifying agent
Benzalkonium chloride	E00536	21988052	Antimicrobial preservative; Penetration agent; Solubilizing agent; Surfactant
Calcium chloride	E00474	5284359	Antimicrobial preservative; Desiccant
Glycerin	E00026	753	Antimicrobial preservative; Emollient; Flavoring agent; Humectant; Lubricant; Plasticizing agent; Solvent; Suppository base; Tonicity agent; Viscosity-controlling agent
Polyvinyl alcohol	E00666	Not Available	Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Sodium chloride	E00077	5234	Diluent; Tonicity agent
Water	E00035	962	Solvent
Boric acid	E00152	7628	Antimicrobial preservative; Buffering agent
Magnesium chloride	E00479	5360315	Viscosity-controlling agent
Sodium borate	E00511	11954323	Alkalizing agent; Antimicrobial preservative; Buffering agent; Emulsifying agent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Brimonidine Tartrate 0.2% solution	0.20%	Solution	Ophthalmic
Brimonidine Tartrate 0.15% solution	0.15%	Solution	Ophthalmic
Brimonidine Tartrate 0.025% solution	0.03%	Solution	Ophthalmic

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] Alpha(2A)-adrenoceptor: G(alphai1) protein-mediated pertussis toxin-resistant attenuation of G(s) coupling to the cyclic AMP pathway. Biochem Pharmacol. 2000 Jun 15;59(12):1531-8.