Details of the Drug Excipient

General Information of Drug Inactive Ingredient (DIG) (ID: E00014)

DIG Name
Kyselina citronova
Synonyms
citric acid; 77-92-9; 2-hydroxypropane-1,2,3-tricarboxylic acid; Citric acid, anhydrous; Anhydrous citric acid; Citro; Citretten; Aciletten; Chemfill; Hydrocerol A; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-; Kyselina citronova; 2-hydroxy-1,2,3-propanetricarboxylic acid; 2-Hydroxytricarballylic acid; Citric acid anhydrous; Caswell No. 221C; F 0001 (polycarboxylic acid); 3-Carboxy-3-hydroxypentane-1,5-dioic acid; 2-Hydroxypropanetricarboxylic acid; FEMA No. 2306; FEMA Number 2306; K-Lyte; Kyselina citronova [Czech]; K-Lyte DS; CCRIS 3292; HSDB 911; EPA Pesticide Chemical Code 021801; Uro-trainer; AI3-06286; UNII-XF417D3PSL; Suby G; MFCD00011669; NSC 30279; NSC 626579; BRN 0782061; CHEMBL1261; XF417D3PSL; Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]; Kyselina 2-hydroxy-1,2,3-propantrikarbonova; CHEBI:30769; .beta.-Hydroxytricarballylic acid; citr; NSC30279; NSC-30279; NSC626579; NSC-626579; Citric acid, 99%; NCGC00090954-03; E330; DSSTox_CID_332; E 330; beta-Hydroxytricarballylic acid; CITRATE ANION; DSSTox_RID_75520; DSSTox_GSID_20332; citric-acid; Citric acid, 99%, pure, anhydrous; 2-hydroxy-1,2,3-propanetricarboxylic; Citric acid [USAN:JAN]; CAS-77-92-9; 1,3-Propanetricarboxylic acid, 2-hydroxy-; Citric acid, 99.5%, for analysis, anhydrous; NSC-112226; EINECS 201-069-1; Citraclean; Citronensaeure; Anhydrous citrate; citric acid group; 2fwp; 4aci; 4nrm; H3cit; Citric acid, anhydrous [USP:JAN]; Citric Acid,(S); Citric acid,anhydrous; Citric acid (8CI); K-Lyte (Salt/Mix); PubChem20283; 1i2s; 1o4l; 1rq2; 1y4a; 2bo4; 2c4v; 2fw6; 4to8; Citraclean (Salt/Mix); ACMC-209pcr; Citric acid-[13C6]; Citric Acid (Anhydrous); 10402-15-0; Spectrum3_001850; WLN: QV1XQVQ1VQ; beta-Hydroxytricarballylate; cid_311; K-Lyte/Cl (Salt/Mix); K-Lyte DS (Salt/Mix); bmse000076; HOC(CH2COOH)2COOH; EC 201-069-1; NCIStruc1_000057; NCIStruc2_000099; NCIOpen2_004062; NCIOpen2_004502; Oprea1_502996; BSPBio_003240; Citric acid anhydrous (JAN); 4-03-00-01272 (Beilstein Handbook Reference); Citric Acid, anhydrous, USP; MLS001066346; citric acid (Fragrance Grade); Citric acid, anhydrous (USP); Anhydrous citric acid (JP17); GTPL2478; INS NO.330; Citric Acid (Industrial Grade); Citric acid, analytical standard; DTXSID3020332; BDBM14672; Citric acid, p.a., 99.5%; KBio3_002740; INS-330; 4o61; Citric acid 5% solution in water; Citric acid, Electrophoresis Grade; HMS1787N01; HMS2268B04; Pharmakon1600-01300013; ZINC895081; Citric acid 10% solution in water; Citric acid 50% solution in water; HY-N1428; STR12052; 1,2,3-Tricarboxy-2-hydroxypropane; Tox21_113436; Tox21_202405; Tox21_300124; ANW-37129; ANW-44011; BBL002530; NSC759606; s5761; SBB008922; STK286098; AKOS000119911; Citric acid, LR, anhydrous, >=99%; 2-hydroxy-1,2,3-propanetricarboxylate; CS-6965; DB04272; MCULE-7981253226; NE10694; NSC-759606; 3-Carboxy-3-hydroxypentane-1,5-dioate; Citric acid, >=99.5%, FCC, FG; Citric acid, ACS reagent, >=99.5%; Citric Acid, anhydrous powder, A.C.S.; 2-Hydroxy-1,3-propanetricarboxylic acid; NCGC00090954-01; NCGC00090954-02; NCGC00090954-04; NCGC00090954-05; NCGC00254055-01; NCGC00259954-01; AK116143; BP-31028; Citric Acid, anhydrous granular, A.C.S.; NCI60_022579; SMR000471840; 2-hydroxy-1,2,3-propanetricarboxyic acid; SBI-0206765.P001; Citric acid, SAJ first grade, >=99.5%; 2-Hydroxy-1,2,3-propane tricarboxylic acid; 2-Hydroxy-1,2,3-propanenetricarboxylic acid; B7297; C1949; Citric Acid, Aqueous Solution (Food Grade); Citric acid, Vetec(TM) reagent grade, 99%; E-330; FT-0623957; FT-0665073; FT-0728530; ST50308093; T8019; Citric acid, 99.6%, ACS reagent, anhydrous; 1466-EP2269610A2; 1466-EP2269986A1; 1466-EP2269988A2; 1466-EP2269989A1; 1466-EP2269990A1; 1466-EP2270002A1; 1466-EP2270003A1; 1466-EP2270006A1; 1466-EP2270008A1; 1466-EP2270011A1; 1466-EP2270017A1; 1466-EP2270505A1; 1466-EP2272516A2; 1466-EP2272537A2; 1466-EP2272817A1; 1466-EP2272822A1; 1466-EP2272825A2; 1466-EP2272827A1; 1466-EP2272832A1; 1466-EP2272834A1; 1466-EP2272841A1; 1466-EP2272843A1; 1466-EP2275102A1; 1466-EP2275105A1; 1466-EP2275401A1; 1466-EP2275403A1; 1466-EP2275404A1; 1466-EP2275410A1; 1466-EP2275411A2; 1466-EP2275412A1; 1466-EP2275413A1; 1466-EP2275414A1; 1466-EP2277507A1; 1466-EP2277848A1; 1466-EP2277858A1; 1466-EP2277866A1; 1466-EP2277867A2; 1466-EP2280000A1; 1466-EP2280001A1; 1466-EP2280003A2; 1466-EP2280004A1; 1466-EP2280009A1; 1466-EP2280010A2; 1466-EP2280012A2; 1466-EP2280020A1; 1466-EP2280021A1; 1466-EP2281559A1; 1466-EP2281563A1; 1466-EP2281813A1; 1466-EP2281816A1; 1466-EP2281817A1; 1466-EP2281818A1; 1466-EP2281819A1; 1466-EP2281820A2; 1466-EP2281823A2; 1466-EP2284149A1; 1466-EP2284160A1; 1466-EP2284169A1; 1466-EP2284178A2; 1466-EP2284179A2; 1466-EP2286795A1; 1466-EP2286811A1; 1466-EP2287153A1; 1466-EP2287155A1; 1466-EP2287156A1; 1466-EP2287160A1; 1466-EP2287161A1; 1466-EP2287162A1; 1466-EP2287165A2; 1466-EP2287166A2; 1466-EP2287167A1; 1466-EP2289509A2; 1466-EP2289510A1; 1466-EP2289518A1; 1466-EP2289876A1; 1466-EP2289879A1; 1466-EP2289883A1; 1466-EP2289887A2; 1466-EP2289888A2; 1466-EP2289890A1; 1466-EP2289893A1; 1466-EP2292227A2; 1466-EP2292228A1; 1466-EP2292231A1; 1466-EP2292233A2; 1466-EP2292234A1; 1466-EP2292592A1; 1466-EP2292593A2; 1466-EP2292611A1; 1466-EP2292612A2; 1466-EP2292615A1; 1466-EP2292617A1; 1466-EP2292619A1; 1466-EP2292620A2; 1466-EP2292621A1; 1466-EP2292622A1; 1466-EP2292628A2; 1466-EP2295053A1; 1466-EP2295401A2; 1466-EP2295402A2; 1466-EP2295406A1; 1466-EP2295407A1; 1466-EP2295408A1; 1466-EP2295410A1; 1466-EP2295412A1; 1466-EP2295413A1; 1466-EP2295414A1; 1466-EP2295415A1; 1466-EP2295416A2; 1466-EP2295418A1; 1466-EP2295424A1; 1466-EP2295426A1; 1466-EP2295427A1; 1466-EP2295432A1; 1466-EP2295433A2; 1466-EP2295437A1; 1466-EP2298731A1; 1466-EP2298734A2; 1466-EP2298735A1; 1466-EP2298736A1; 1466-EP2298742A1; 1466-EP2298744A2; 1466-EP2298746A1; 1466-EP2298747A1; 1466-EP2298748A2; 1466-EP2298750A1; 1466-EP2298751A2; 1466-EP2298754A1; 1466-EP2298755A1; 1466-EP2298757A2; 1466-EP2298758A1; 1466-EP2298759A1; 1466-EP2298767A1; 1466-EP2298768A1; 1466-EP2298772A1; 1466-EP2298775A1; 1466-EP2298776A1; 1466-EP2298778A1; 1466-EP2298779A1; 1466-EP2301536A1; 1466-EP2301538A1; 1466-EP2301544A1; 1466-EP2301922A1; 1466-EP2301923A1; 1466-EP2301925A1; 1466-EP2301928A1; 1466-EP2301929A1; 1466-EP2301930A1; 1466-EP2301931A1; 1466-EP2301933A1; 1466-EP2301934A1; 1466-EP2301935A1; 1466-EP2301936A1; 1466-EP2301937A1; 1466-EP2301939A1; 1466-EP2301940A1; 1466-EP2301941A1; 1466-EP2305219A1; 1466-EP2305248A1; 1466-EP2305250A1; 1466-EP2305257A1; 1466-EP2305633A1; 1466-EP2305636A1; 1466-EP2305641A1; 1466-EP2305646A1; 1466-EP2305651A1; 1466-EP2305652A2; 1466-EP2305653A1; 1466-EP2305655A2; 1466-EP2305657A2; 1466-EP2305659A1; 1466-EP2305663A1; 1466-EP2305664A1; 1466-EP2305666A1; 1466-EP2305668A1; 1466-EP2305672A1; 1466-EP2305673A1; 1466-EP2305674A1; 1466-EP2305675A1; 1466-EP2305682A1; 1466-EP2305683A1; 1466-EP2305684A1; 1466-EP2305687A1; 1466-EP2305808A1; 1466-EP2308479A2; 1466-EP2308492A1; 1466-EP2308510A1; 1466-EP2308562A2; 1466-EP2308812A2; 1466-EP2308828A2; 1466-EP2308838A1; 1466-EP2308839A1; 1466-EP2308849A1; 1466-EP2308850A1; 1466-EP2308851A1; 1466-EP2308854A1; 1466-EP2308857A1; 1466-EP2308861A1; 1466-EP2308869A1; 1466-EP2308871A1; 1466-EP2308872A1; 1466-EP2308873A1; 1466-EP2308875A1; 1466-EP2308877A1; 1466-EP2308879A1; 1466-EP2311455A1; 1466-EP2311494A1; 1466-EP2311807A1; 1466-EP2311808A1; 1466-EP2311809A1; 1466-EP2311810A1; 1466-EP2311811A1; 1466-EP2311814A1; 1466-EP2311818A1; 1466-EP2311820A1; 1466-EP2311821A1; 1466-EP2311822A1; 1466-EP2311823A1; 1466-EP2311824A1; 1466-EP2311827A1; 1466-EP2311829A1; 1466-EP2311830A1; 1466-EP2311831A1; 1466-EP2311834A1; 1466-EP2311837A1; 1466-EP2311839A1; 1466-EP2311840A1; 1466-EP2311842A2; 1466-EP2311850A1; 1466-EP2314574A1; 1466-EP2314575A1; 1466-EP2314576A1; 1466-EP2314577A1; 1466-EP2314584A1; 1466-EP2314585A1; 1466-EP2314586A1; 1466-EP2314587A1; 1466-EP2314589A1; 1466-EP2314593A1; 1466-EP2316457A1; 1466-EP2316458A1; 1466-EP2316459A1; 1466-EP2316470A2; 1466-EP2316824A1; 1466-EP2316825A1; 1466-EP2316826A1; 1466-EP2316827A1; 1466-EP2316828A1; 1466-EP2316829A1; 1466-EP2316831A1; 1466-EP2316832A1; 1466-EP2316833A1; 1466-EP2316834A1; 1466-EP2316835A1; 1466-EP2316836A1; 1466-EP2316837A1; 1466-EP2316974A1; 1466-EP2371799A1; 1466-EP2371802A1; 1466-EP2371811A2; 1466-EP2371814A1; 1466-EP2372017A1; 1466-EP2374454A1; 1466-EP2374526A1; 1466-EP2374780A1; 1466-EP2374781A1; 1466-EP2374790A1; 1466-EP2374895A1; 1466-EP2377510A1; 1466-EP2377848A1; 1466-EP2380568A1; C00158; D00037; 111855-EP2295439A1; 111855-EP2298761A1; AE-562/40806920; Citric acid, BioUltra, anhydrous, >=99.5% (T); Q159683; J-520099; 1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI); Z56754862; Citric acid, certified reference material, TraceCERT(R); Citric acid, meets USP testing specifications, anhydrous; F2191-0222; 8F5D336A-442D-434A-9FB0-E400FF74E343; Citrate standard for IC, 1000 mg/L, analytical standard; 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID); Citric acid, United States Pharmacopeia (USP) Reference Standard; Citric acid, anhydrous, cell culture tested, plant cell culture tested; Citric acid, anhydrous, European Pharmacopoeia (EP) Reference Standard; Citric acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.5%; Citric acid, for molecular biology, anhydrous, Rnase and Protease free; Citric acid, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material; Citric acid, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance)
DIG Function
Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Formula
C6H8O7
Canonical SMILES
C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI
1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChIKey
KRKNYBCHXYNGOX-UHFFFAOYSA-N
Physicochemical Properties Molecular Weight 192.12 Topological Polar Surface Area 132
XlogP -1.7 Complexity 227
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7

Full List of Drug(s) Co-administrated with This DIG

68 Approved Drug(s) Co-administrated with This DIG
Drug Name Drug ID Indication Formulation Name Formulation ID
Acetaminophen DMUIE76 Allergic rhinitis [CA08.0] Acetaminophen 500 mg tablet F00459
Alendronate DMY2KX9 Bone Paget disease [] Alendronic acid 70 mg tablet F00642
Amcinonide DMM1JL9 Exanthem [] Amcinonide 0.1% ointment F23618
Atenolol DMNKG1Z Angina pectoris [BA40] Atenolol 100 mg tablet F01840
BAY 80-6946 DMLOS5R Follicular lymphoma [2A80] Copanlisib 60 mg For Injection F23120
Benzocaine DMI18HW Anaesthesia [9A78.6] Benzocaine 6 mg tablet F02345
Betamethasone DMAHJEF Acute adrenal insufficiency [] Betamethasone Valerate 0.12% aerosol F23643
Buprenorphine DMPRI8G Opioid dependence [6C43.2Z] Buprenorphine 2 mg tablet F02767
Cannabidiol DM0659E Dravet syndrome [8A61.11] Cannabidiol 1.938 g/100 ml spray F23665
Carfilzomib DM48K0X Multiple myeloma [2A83] Carfilzomib 60mg/vial powder F24030
Cetirizine DMOMP9U Allergic rhinitis [CA08.0] Cetirizine 10 mg tablet F03872
Chloroquine DMSI5CB Malaria [1F40-1F45] Chloroquine 250 mg tablet F04001
CHLOROXINE DMFZBMQ Erythema [ME64.0] Chloroxine 4% solution F23114
Clarithromycin DM4M1SG Acute maxillary sinusitis [] Clarithromycin 500 mg tablet F04448
Clofazimine DMEBOFW Crohn disease [DD70] Clofazimine 100mg capsule F23118
Dacarbazine DMNPZL4 Adenocarcinoma [2D40] Dacarbazine 200mg/vial injectable F23123
Desloratadine DM56YN7 Allergic rhinitis [CA08.0] Desloratadine 2.5 mg tablet F05382
Desonide DMTP2NJ Allergic rhinitis [CA08.0] Desonide 0.05% lotion F23703
Desoximetasone DM4PXF6 Exanthem [] Desoximetasone 0.05% ointment F23707
Dexlansoprazole DM1DBV5 Erosive esophagitis [DA25.0] Dexlansoprazole 30 mg tablet F05486
Dextromethorphan DMUDJZM Allergic rhinitis [CA08.0] Dextromethorphan 15mg/5ml Syrup F23419
Dimenhydrinate DM264B3 Meniere disease [AB31.0] Dimenhydrinate 50 mg tablet F06208
Diphenhydramine DMKQTBA Hyperemesis gravidarum [] Diphenhydramine 12.5 mg tablet F06240
Dopamine DMPGUCF Acromegaly [5A60.0] Dopamine Hydrochloride 40mg/ml injectable F23434
Dutasteride DMQ4TJK Benign prostatic hyperplasia [GA90] Dutasteride 0.5 mg capsule F07168
Efinaconazole DMFA9MV Fungal infection [1F29-1F2F] Efinaconazole 10% solution F23148
Erythromycin DM4K7GQ Acne vulgaris [ED80] Erythromycin 400 mg tablet F07382
Esomeprazole DM7BN0X Cystic fibrosis [CA25] Esomeprazole 20 mg capsule F07502
Etoposide DMNH3PG Acute myelogenous leukaemia [2A41] Etoposide 50 mg capsule F07800
Famotidine DMRL3AB Gastric ulcer [DA60] Famotidine 40mg/5ml for suspension F23511
Fentanyl DM8WAHT Analgesia [MB40.8] Fentanyl 0.1 mg tablet F08097
Fexofenadine DM17ONX Allergic rhinitis [CA08.0] Fexofenadine 30 mg tablet F08173
Fluconazole DMOWZ6B Cryptococcal meningitis [] Fluconazole 100 mg tablet F08322
Fluocinonide DM65KL8 Exanthem [] Fluocinonide 0.05% solution F23749
Flurbiprofen DMGN4BY Osteoarthritis [FA00-FA05] Flurbiprofen Sodium 0.03% solution F23344
Granisetron DMIUW25 Malignant glioma [2A00.0] Granisetron Hydrochloride eq 1mg base/ml injectable F23544
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia [2A20.0] Hydroxyurea 500 mg capsule F09899
Ibuprofen DM8VCBE Dysmenorrhea [GA34.3] Ibuprofen 100 mg tablet F10471
Isoproterenol DMK7MEY Atrioventricular block [] Isoproterenol 1mg/5ml solution F23794
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite [1F6B] Ivermectin 3 mg tablet F10913
Labetalol DMK8U72 Hypertension [BA00-BA04] Labetalol Hydrochloride 5mg/ml injectable F23470
Larotrectinib DM26CQR Solid tumour/cancer [2A00-2F9Z] Larotrectinib 20 mg/ml solution F24272
Lefamulin DME6G97 Community-acquired pneumonia [CA40.Z] Lefamulin 150 mg Injection F23803
Lofexidine DM1WXA6 Heroin and opiate withdrawal [6C43] Lofexidine 0.18 mg tablet F23214
Loratadine DMF3AN7 Allergy [4A80-4A85] Loratadine 10 mg tablet F12496
Mefenamic acid DMK7HFI Dysmenorrhea [GA34.3] Mefenamic acid 250 mg capsule F12842
Mesalazine DMOL5IU Diverticulitis [] Mesalamine 375 mg capsule F13051
Methyldopa DM5I621 Hypertension [BA00-BA04] Methyldopa 500 mg tablet F13518
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder [6A05.Z] Methylphenidate 10 mg tablet F13536
Mirtazapine DML53ZJ Depression [6A70-6A7Z] Mirtazapine 15 mg tablet F14194
Nadolol DMW6GVL Angina pectoris [BA40] Nadolol 80 mg tablet F14848
Naproxen DMZ5RGV Bursitis [] Naproxen 750 mg tablet F14979
Nateglinide DMLK2QH Diabetic complication [5A2Y] Nateglinide 120 mg tablet F15106
Oxymetazoline DM8ZXT6 Arrhythmia [BC9Z] Oxymetazoline 1% cream F23856
Permethrin DMZ0Q1G Pediculus capitis infestation [1G00.0] Permethrin 1% lotion F23867
Pralsetinib DMWU0I2 Non-small-cell lung cancer [2C25.Y] Pralsetinib 100 mg capsule F23262
Prednisolone DMQ8FR2 Acute adrenal insufficiency [] Prednisolone 20 mg tablet F17746
Quetiapine DM1N62C Anorexia nervosa cachexia [6B80] Quetiapine 25 mg tablet F18417
Ranitidine DM0GUSX Gastric ulcer [DA60] Ranitidine Hydrochloride eq 25 mg base/mL injectable F23535
Revefenacin DMMP5SI Chronic obstructive pulmonary disease [CA22] Revefenacin 175 mcg/3 ml solution F23271
Selegiline DM6034S Major depressive disorder [6A70.3] Selegiline 5 mg capsule F19740
Simvastatin DM30SGU Arteriosclerosis [BD40] Simvastatin 20 mg tablet F20076
Streptozocin DMOF7AT Pancreatic cancer [2C10] Streptozocin 1gm/vial injectable F23292
Taxol DMUOT9V Breast cancer [2C60-2C65] Paclitaxel 6mg/ml injectable F23859
Temozolomide DMKECZD Adenocarcinoma [2D40] Temozolomide 20 mg capsule F20866
Temsirolimus DMS104F Renal cell carcinoma [2C90] Temsirolimus 25mg/ml solution F23303
Tranylcypromine DMGB5RE Major depressive disorder [6A70.3] Tranylcypromine 10 mg tablet F21589
Zolmitriptan DM1IB4Q Migraine [8A80] Zolmitriptan 2.5 mg tablet F22867
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⏷ Show the Full List of 68 Approved Drug(s)
3 Clinical Trial Drug(s) Co-administrated with This DIG
Drug Name Drug ID Indication Formulation Name Formulation ID
ABT-492 DMJFD2I Bacterial infection [1A00-1C4Z] Delafloxacin 450 mg tablet F05288
PHN-131 DM1SV8I Pain [MG30-MG3Z] Nalbuphine Hydrochloride 10mg/ml injectable F23236
Impoyz DMB1N6P Scalp dermatosis [] Clobetasol Propionate 0.05% aerosol F23047
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2 Investigative Drug(s) Co-administrated with This DIG
Drug Name Drug ID Indication Formulation Name Formulation ID
Brominide tartrate DMMC4BY Discovery agent [N.A.] Brimonidine Tartrate 0.2% solution F23653
Oxybutynine DMJPBAX Obsolete neurogenic bladder [] Oxybutynin 5mg/5ml Syrup F23501
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