General Information of Drug (ID: DMNG9B2)

Drug Name
Cis-2-Fluoro-2-(4-methoxyphenyl)cyclopropylamine
Synonyms CHEMBL468854; cis-2-Fluoro-2-(4-methoxyphenyl)cyclopropylamine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 181.21
Logarithm of the Partition Coefficient (xlogp) 1.2
Rotatable Bond Count (rotbonds) 2
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 3
Chemical Identifiers
Formula
C10H12FNO
IUPAC Name
(1R,2S)-2-fluoro-2-(4-methoxyphenyl)cyclopropan-1-amine
Canonical SMILES
COC1=CC=C(C=C1)[C@]2(C[C@H]2N)F
InChI
InChI=1S/C10H12FNO/c1-13-8-4-2-7(3-5-8)10(11)6-9(10)12/h2-5,9H,6,12H2,1H3/t9-,10+/m1/s1
InChIKey
IFVJHRWUMHINNO-ZJUUUORDSA-N
Cross-matching ID
PubChem CID
44577747
TTD ID
D0B2TV

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 2.65E-02 1.12E-02 0.07
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases... Bioorg Med Chem. 2008 Aug 1;16(15):7148-66.