Details of the Drug

General Information of Drug (ID: DMNVKU6)

• Drug Name: crisaborole
• Synonyms: Crisaborole ointment 2%; PF-06930164

Indication

Disease Entry	ICD 11	Status	REF
Atopic dermatitis	EA80	Approved	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight; 251.05
  Logarithm of the Partition Coefficient; Not Available
  Rotatable Bond Count; 2
  Hydrogen Bond Donor Count; 1
  Hydrogen Bond Acceptor Count; 4
• ADMET Property: Metabolism: The drug is metabolized via the hydrolysis []
• Chemical Identifiers:
  Formula: C14H10BNO3
  IUPAC Name: 4-[(1-hydroxy-3H-2,1-benzoxaborol-5-yl)oxy]benzonitrile
  Canonical SMILES: B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O
  InChI: InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
  InChIKey: USZAGAREISWJDP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 44591583
  ChEBI ID: CHEBI:134677
  CAS Number: 906673-24-3
  DrugBank ID: DB05219
  TTD ID: D08NWF
  ACDINA ID: D00968

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4 (PDE4)	TTV5CGO	NOUNIPROTAC	Modulator	[1]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Butylated hydroxytoluene	E00336	31404	Antioxidant
Glyceryl monostearate	E00310	24699	Emollient; Emulsifying agent; Emulsion stabilizing agent; Solubilizing agent; Surfactant; Viscosity-controlling agent
Edetate calcium disodium	E00487	6093170	Complexing agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Crisaborole 2% ointment	2%	Ointment	Topical

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.