General Information of Disease (ID: DISTCP41)

Disease Name Atopic dermatitis
Synonyms Besnier's prurigo; Atopic neurodermatitis; allergic; atopic eczema; allergic form of dermatitis; eczema; eczematous dermatitis; Atopic dermatitis; allergic dermatitis
Disease Class EA80: Atopic eczema
Definition
A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
Disease Hierarchy
DIS48ZAP: Allergy
DISY5SZC: Dermatitis
DISSCALK: Hereditary skin disorder
DISTCP41: Atopic dermatitis
ICD Code
ICD-11
ICD-11: EA80
ICD-10
ICD-10: L20
Disease Identifiers
MONDO ID
MONDO_0004980
MESH ID
D003876
UMLS CUI
C0011615
OMIM ID
603165
MedGen ID
41502
HPO ID
HP:0001047
SNOMED CT ID
200775004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 15 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Abrocitinib DM8J29L Approved NA [1]
Anapsos DMV96ZH Approved NA [2]
cortisone DMU5QZX Approved Small molecular drug [3]
crisaborole DMNVKU6 Approved Small molecular drug [4]
Cromolyn sodium DMXXSEA Approved Small molecular drug [5]
Desonide DMTP2NJ Approved Small molecular drug [6]
Dupilumab DMOAD2Y Approved Antibody [7]
Pimecrolimus DMZLGRB Approved Small molecular drug [8]
Prednisone DM2HG4X Approved Small molecular drug [9]
Roflumilast DMPGHY8 Approved Small molecular drug [10]
Ruxolitinib DM7Q98D Approved Small molecular drug [9]
Secukinumab DMYXT2U Approved Monoclonal antibody [11]
Tapinarof DMRPI2Q Approved NA [12]
Tralokinumab DM6ENSJ Approved Monoclonal antibody [13]
Upadacitinib DM32B5U Approved NA [9]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 Drug(s)
This Disease is Treated as An Indication in 68 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ARQ-151 DML61S4 Phase 3 Small molecular drug [14]
CBP-201 DMWYNN1 Phase 3 Antibody [15]
Dupixent DMH0W9R Phase 3 NA [9]
IDP-124 DM2OH0S Phase 3 NA [9]
Lebrikizumab DMQP0X5 Phase 3 Monoclonal antibody [9]
LY-686017 DM7WORZ Phase 3 Small molecular drug [9]
MABp1 DM8D13S Phase 3 NA [9]
Nemolizumab DMH9EUA Phase 3 NA [16]
Omiganan DM7UF9M Phase 3 NA [9]
Rocatinlimab DMG1U5K Phase 3 Monoclonal antibody [17]
SAR231893 DMHFBOG Phase 3 NA [18]
Bimosiamose DM0TH9A Phase 2a Small molecular drug [19]
ADX-914 DMYM6FU Phase 2 Monoclonal antibody [20]
ALX-101 DMCAFXM Phase 2 NA [9]
Amlitelimab DMKR3BQ Phase 2 Antibody [21]
AN-2898 DMDK7CL Phase 2 NA [22]
AN0128 DMT3S10 Phase 2 Small molecular drug [23]
ANB-020 DM7UF6D Phase 2 NA [9]
ASB17061 DMNVU28 Phase 2 NA [24]
ATI-502 DM8NODR Phase 2 Small molecular drug [25]
BMX-010 DM6CJ12 Phase 2 NA [9]
BRT-FC-83C DMAOIU6 Phase 2 NA [26]
Cerdulatinib DMSCR2H Phase 2 NA [9]
Cis-urocanic acid DMPODP6 Phase 2 Small molecular drug [27]
DMT210 DMK9PMK Phase 2 Small molecular drug [9]
DPK-060 DM059CZ Phase 2 NA [28]
E6005 DM1S489 Phase 2 Small molecular drug [29]
GBR 830 DM2VO9T Phase 2 NA [9]
GW-870086-X DM489FT Phase 2 NA [30]
HL-009 DMK2RZI Phase 2 NA [31]
JNJ-26113100 DMUVQDC Phase 2 NA [32]
K-201 DMZCVD7 Phase 2 Small molecular drug [33]
LAS-41004 DMQ02M9 Phase 2 NA [34]
LEO-29102 DM6LGF9 Phase 2 NA [35]
MM36 DM6VPIO Phase 2 Small molecular drug [9]
NCX 1022 DM4W28K Phase 2 NA [36]
PAC-14028 DM3816P Phase 2 NA [37]
PF-07038124 DMI4RUI Phase 2 Small molecule [38]
PF-3893787 DMC2FAL Phase 2 Small molecular drug [9]
PMX-53 DMZUAJ4 Phase 2 Small molecular drug [39]
PRO22 DMMEL6B Phase 2 NA [9]
Q-301 DMLRBXM Phase 2 NA [9]
Q301 DME71WA Phase 2 Small molecular drug [40]
RVT-505 DM3C9F8 Phase 2 NA [9]
S-777469 DMZGNOJ Phase 2 NA [41]
Santalum DMM9KK9 Phase 2 NA [9]
SAR 444727 DMWPMN2 Phase 2 Small molecule [42]
SRD-441 DM5GAC4 Phase 2 NA [43]
TA-7906 DMZTAJL Phase 2 NA [44]
TS-022 DMMNXIW Phase 2 NA [45]
UCB1381 DMV7AWN Phase 2 NA [46]
VTB-38543 DMNY3J0 Phase 2 NA [9]
Zabedosertib DMEZGWP Phase 2 Small molecule [47]
KP-413 DM9CSWK Phase 1/2 NA [48]
REGN-846 DM81MAE Phase 1/2 NA [49]
ZPL521 DMPZE2G Phase 1/2 NA [9]
EDP1066 DMPUE9M Phase 1 NA [9]
KPL-716 DMYBHER Phase 1 NA [9]
PF-06817024 DMSJOTL Phase 1 NA [9]
PF-07242813 DMFC0ZB Phase 1 Small molecule [50]
PF-07264660 DM0GI2H Phase 1 Antibody [51]
PF-07275315 DMHRVUY Phase 1 Antibody [52]
PF-07295324 DMBE63K Phase 1 Small molecule [53]
SAR444656 DMIF2OL Phase 1 Nanobody [54]
SB414 DMB834E Phase 1 NA [9]
SNA-125 DM8L1GJ Phase 1 NA [9]
STMC-103H DMPX83E Phase 1 Live biotherapeutic product [55]
UCB9741 DMJZB5E Phase 1 NA [56]
------------------------------------------------------------------------------------
⏷ Show the Full List of 68 Drug(s)
This Disease is Treated as An Indication in 2 Patented Agent(s)
Drug Name Drug ID Highest Status Drug Type REF
Piperazine derivative 5 DMDFUBH Patented Small molecular drug [57]
Quinazoline derivative 13 DMFU6OD Patented Small molecular drug [57]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 5 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
P-1 DMFNLDY Discontinued in Phase 3 Small molecular drug [58]
AVAC DMHLR34 Discontinued in Phase 2 NA [59]
Dermolastin DM6WSU2 Discontinued in Phase 2 Small molecular drug [60]
GW842470X DMLC154 Discontinued in Phase 2 NA [41]
CD-581 DMOCBQW Discontinued in Phase 1 NA [61]
------------------------------------------------------------------------------------
This Disease is Treated as An Indication in 12 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AP-1189 DMRZMKT Investigative NA [62]
C-0333158 DM6X6P9 Investigative NA [63]
DM-107 DMRYQVJ Investigative NA [64]
DPS-201 DMAP3QG Investigative NA [63]
J-555Y DMC3A9V Investigative NA [63]
KF-66490 DMOUW0A Investigative Small molecular drug [65]
MLR-1130 DMGQQOR Investigative NA [63]
PBI-1308 DM025CX Investigative NA [63]
RESP-6000 DMMU3S3 Investigative NA [63]
RTU-1096 DMWVBD9 Investigative NA [66]
SWT-01113 DMLQEDI Investigative NA [63]
SWT-05141 DMBNWK4 Investigative NA [63]
------------------------------------------------------------------------------------
⏷ Show the Full List of 12 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 142 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CA2 TTANPDJ Limited Altered Expression [67]
CCR8 TTE836A Limited Biomarker [68]
CD1A TTBGTFN Limited Altered Expression [69]
CLDN4 TTMTS9H Limited Altered Expression [70]
CXCL2 TTZF0K2 Limited Altered Expression [71]
CYP24A1 TT82UI1 Limited Genetic Variation [72]
FCER1G TTDGEC0 Limited Altered Expression [73]
FCER2 TTCH6MU Limited Altered Expression [74]
HNMT TT2B6EV Limited Biomarker [75]
IL12B TTGW72V Limited Biomarker [76]
IL13RA1 TTNEAMG Limited Genetic Variation [77]
IL13RA2 TTMPZ7V Limited Altered Expression [78]
IL33 TT5MD4P Limited Biomarker [79]
KIR2DS1 TTVWAGF Limited Biomarker [80]
LANCL1 TTZW8NS Limited Biomarker [81]
MGMT TTJ8DV7 Limited Genetic Variation [82]
NLRP1 TTQX29T Limited Biomarker [83]
NPSR1 TTV1C0Z Limited Genetic Variation [84]
NTSR1 TTTUMEP Limited Biomarker [85]
ORAI1 TTE76YK Limited Biomarker [86]
PLA2G1B TT9V5JH Limited Biomarker [87]
PSEN2 TTWN3F4 Limited Biomarker [88]
PTGDR TTNVEIR Limited Biomarker [89]
SMPD2 TTE5VI6 Limited Genetic Variation [90]
TAP1 TT7JZI8 Limited Biomarker [91]
TBXA2R TT2O84V Limited Genetic Variation [92]
TNFSF14 TTKVENM Limited Biomarker [93]
TRPM8 TTXDKTO Limited Biomarker [94]
IL21 TT9QEJ6 Disputed Biomarker [95]
BACH1 TT2ME4S moderate Biomarker [96]
CCR3 TTD3XFU moderate Biomarker [97]
COL6A3 TT5WCAH moderate Biomarker [98]
CXCR3 TT1UCIJ moderate Biomarker [99]
IL20 TTNZMY2 moderate Biomarker [100]
MAPK8 TT0K6EO moderate Biomarker [101]
ACKR1 TTKY2NS Strong Biomarker [93]
ADAM17 TT6AZXG Strong Altered Expression [102]
ADAM33 TTQICM2 Strong Genetic Variation [103]
ADM2 TTM642F Strong Altered Expression [104]
ALOX12B TTQ4QQH Strong Altered Expression [105]
AQP3 TTLDNMQ Strong Altered Expression [106]
BMX TTN2I9E Strong Biomarker [107]
CAMP TTULOB6 Strong Biomarker [108]
CASP1 TTCQIBE Strong Altered Expression [109]
CASP8 TT6SZNG Strong Biomarker [110]
CCL20 TT2XAZY Strong Biomarker [111]
CCL22 TTBTWI1 Strong Altered Expression [112]
CCL23 TTHAPJK Strong Biomarker [113]
CCL3 TT8I4WB Strong Altered Expression [114]
CCL5 TT9DWLC Strong Biomarker [115]
CCR5 TTJIH8Q Strong Biomarker [116]
CD28 TTQ13FT Strong Altered Expression [117]
CMA1 TT8VUE0 Strong Genetic Variation [118]
CTSE TTLXC4Q Strong Biomarker [119]
CTSH TT3G406 Strong Altered Expression [120]
CTSV TTSD9T1 Strong Altered Expression [121]
CXCL9 TTWE5PB Strong Altered Expression [122]
CYSLTR1 TTGKOY9 Strong Genetic Variation [123]
DEFB4A TTIVY12 Strong Biomarker [108]
ERAP1 TT60XFL Strong Genetic Variation [80]
ERAP2 TTVGS1C Strong Genetic Variation [80]
F2RL1 TTQR74A Strong Biomarker [124]
FOXQ1 TTEJZOL Strong Altered Expression [125]
GATA3 TT45KOB Strong Biomarker [126]
HLA-DRB1 TTUXSTW Strong Biomarker [127]
HRH4 TTXJ178 Strong Biomarker [128]
HTR1A TTSQIFT Strong Biomarker [129]
ICOSLG TTB9Z8R Strong Altered Expression [130]
IFNL3 TTRF4Q2 Strong Biomarker [131]
IKZF3 TTCZVFZ Strong Genetic Variation [132]
IL10RB TTJTRMK Strong Altered Expression [133]
IL12RB2 TT4SWR8 Strong Genetic Variation [134]
IL15RA TTGN89I Strong Biomarker [135]
IL1R1 TTWOTEA Strong Genetic Variation [136]
IL1RL1 TT4GZA4 Strong Genetic Variation [137]
IL21R TTZO9B0 Strong Biomarker [138]
IL22 TTLDX4N Strong Biomarker [139]
IL25 TTVMO5W Strong Biomarker [140]
IL31 TT1RJXK Strong Biomarker [141]
IL31RA TT9HPX0 Strong Altered Expression [142]
IL32 TTD4G7L Strong Altered Expression [143]
IL36G TT8SLDN Strong Altered Expression [144]
IL37 TTQTX98 Strong Altered Expression [145]
IL4R TTDWHC3 Strong Biomarker [146]
IL6 TTT1V78 Strong Genetic Variation [147]
IL9 TT0JTFD Strong Biomarker [148]
ITCH TT5SEWD Strong Biomarker [149]
ITK TT3C80U Strong Biomarker [150]
JAK1 TT6DM01 Strong Biomarker [151]
KLK5 TTULSEW Strong Altered Expression [152]
KLK6 TTLPF4X Strong Biomarker [153]
KLK7 TTE6GTB Strong Genetic Variation [154]
KRT17 TTKV0EC Strong Biomarker [155]
KYNU TTWQM3J Strong Biomarker [156]
LRRC32 TT0FAYT Strong Genetic Variation [157]
LTB TTHQ6US Strong Biomarker [158]
LTB4R TTN53ZF Strong Biomarker [158]
LTF TTSZDQU Strong Biomarker [159]
MAOB TTGP7BY Strong Biomarker [160]
MAS1 TTOISYB Strong Genetic Variation [161]
MGLL TTZ963I Strong Biomarker [162]
MUSK TT6SA0X Strong Genetic Variation [163]
NAAA TTMN4HY Strong Biomarker [164]
NFKBIA TTSHAEB Strong Biomarker [165]
NR1I2 TT7LCTF Strong Altered Expression [166]
NTF4 TTIM2WO Strong Biomarker [167]
PCSK7 TTD30LY Strong Biomarker [168]
PDE4A TTZ97H5 Strong Biomarker [169]
PDE4B TTVIAT9 Strong Biomarker [170]
PDE7A TT1BC3A Strong Biomarker [171]
PDZK1 TTDTBLM Strong Biomarker [172]
POSTN TT8ALTZ Strong Altered Expression [173]
PPARA TTJ584C Strong Biomarker [174]
PTGDR2 TTQDMX5 Strong Biomarker [89]
QPCT TTJ7YTV Strong Biomarker [175]
RBPJ TT72D4Z Strong Genetic Variation [176]
REL TT1ZCTH Strong Genetic Variation [177]
S100A8 TT4AF6N Strong Biomarker [178]
SCGB1A1 TTONPVW Strong Biomarker [179]
SELE TT1PL7M Strong Biomarker [180]
SELP TTE5VG0 Strong Altered Expression [181]
SERPINB3 TT6QLPX Strong Biomarker [182]
SLC27A4 TT20AYF Strong Biomarker [183]
SLC6A4 TT3ROYC Strong Genetic Variation [184]
SOCS3 TTI0ME6 Strong Biomarker [185]
SRR TTZFUY6 Strong Biomarker [186]
STAT6 TTWOE1T Strong Biomarker [187]
SYK TT2HUPM Strong Biomarker [188]
TBX21 TTNF9PH Strong Biomarker [189]
TGM1 TT7A949 Strong Genetic Variation [190]
TLR2 TTY7ZHS Strong Genetic Variation [191]
TLR6 TTWRI8V Strong Genetic Variation [192]
TNFRSF14 TTWGTC1 Strong Biomarker [93]
TNFRSF18 TTG6LA7 Strong Biomarker [193]
TNFSF12 TTBTDM1 Strong Biomarker [194]
TRPA1 TTELV3W Strong Biomarker [195]
TRPV1 TTMI6F5 Strong Biomarker [196]
TRPV3 TT946IA Strong Biomarker [197]
TSLP TTHMW3T Strong Biomarker [198]
VIPR2 TT4O5P0 Strong Altered Expression [199]
CXCL10 TTQOVYA Definitive Biomarker [111]
IL19 TT87RWS Definitive Altered Expression [200]
------------------------------------------------------------------------------------
⏷ Show the Full List of 142 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC11A1 DT650XW Strong Biomarker [201]
SLC2A2 DTUJPOL Strong Altered Expression [202]
SLC52A1 DT7NOKR Strong Altered Expression [166]
------------------------------------------------------------------------------------
This Disease Is Related to 9 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP27A1 DEBS639 Limited Genetic Variation [203]
PGM3 DER0EN5 Limited Genetic Variation [204]
PTGDS DER3H9C Limited Altered Expression [205]
TGM3 DEOEB3Q Limited Biomarker [206]
BLMH DECH1VP Strong Biomarker [207]
CHST3 DEQIZP2 Strong Biomarker [208]
TGM5 DEW8QEH Strong Genetic Variation [190]
UBASH3B DE10BJ5 Strong Biomarker [209]
UGT1A9 DE85D2P Strong Genetic Variation [210]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 DME(s)
This Disease Is Related to 227 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADAM11 OTPTVW5W Limited Biomarker [211]
ANXA6 OT9KIQ0Y Limited Biomarker [209]
APOC1 OTA58CED Limited Biomarker [212]
ARHGEF2 OTBQTFRT Limited Biomarker [81]
ARHGEF40 OTFSKXG9 Limited Biomarker [213]
ARMH1 OTTJC0D6 Limited Biomarker [81]
BCL3 OT1M5B95 Limited Biomarker [214]
CARD11 OTRCTLYC Limited Genetic Variation [215]
CCL26 OT2B7HR9 Limited Altered Expression [216]
CCL8 OTCTWYN8 Limited Biomarker [217]
CCR10 OT7ZWSSD Limited Altered Expression [130]
CD1C OT4XINUJ Limited Biomarker [218]
CHGA OTXYX5JH Limited Altered Expression [219]
CHST8 OTQT4TKR Limited Genetic Variation [82]
CLDN23 OTN5RV40 Limited Biomarker [220]
CLDN8 OT7IIWXG Limited Biomarker [221]
CNGB1 OTA5DE38 Limited Biomarker [222]
CRABP2 OTY01V9G Limited Biomarker [223]
DSG1 OT11HC3A Limited Altered Expression [224]
EBNA1BP2 OTBRVMZH Limited Biomarker [81]
ELOVL3 OTH70U4Z Limited Altered Expression [168]
ELOVL6 OTB26UJJ Limited Altered Expression [168]
FCER1A OTIRUOHF Limited Genetic Variation [225]
FLNB OTPCOYL6 Limited Genetic Variation [91]
HAS3 OTPM8IL8 Limited Biomarker [226]
HAVCR1 OT184CRZ Limited Genetic Variation [227]
HLA-DOA OTZE5Q7R Limited Altered Expression [228]
IL18R1 OT83XMPQ Limited Genetic Variation [136]
IL6R OTCQL07Z Limited Genetic Variation [147]
KRT1 OTIOJWA4 Limited Altered Expression [223]
LELP1 OTOQIVV0 Limited Altered Expression [229]
LORICRIN OTFRPVEO Limited Altered Expression [230]
MFN2 OTPYN8A3 Limited Genetic Variation [82]
MS4A2 OTMCAS2D Limited Biomarker [231]
MYT1L OTV45MAS Limited Genetic Variation [82]
NELL2 OTS4MJZ7 Limited Biomarker [232]
NXF1 OTEFHXG6 Limited Genetic Variation [91]
OVOL1 OTFJ62UI Limited Biomarker [233]
PACC1 OTKBS8CC Limited Biomarker [196]
PLB1 OTZ6TTYV Limited Biomarker [87]
PSMD7 OT7PZZ4K Limited Biomarker [81]
PTPRN2 OTL6SH28 Limited Genetic Variation [82]
RABEPK OTCZSREH Limited Biomarker [81]
RASIP1 OTCRY2AN Limited Genetic Variation [82]
RBP2 OTR8QG5V Limited Biomarker [223]
RNASE2 OT8Z4FNE Limited Biomarker [234]
SEC14L2 OTJST64D Limited Genetic Variation [91]
SELENOS OTUEWIU9 Limited Genetic Variation [235]
SESTD1 OTHH06X8 Limited Biomarker [213]
SPRR1A OTJMI34A Limited Altered Expression [229]
TFIP11 OT7NVSWU Limited Biomarker [85]
TMEM232 OTHUG6HO Limited Genetic Variation [127]
TNFRSF6B OTKAN9G7 Limited Genetic Variation [82]
TNXB OTVBWAV5 Limited Genetic Variation [82]
COL6A2 OTQC6PPO moderate Genetic Variation [98]
S100A11 OTI57KDN moderate Altered Expression [133]
ACTL9 OTDOBD9M Strong Genetic Variation [236]
ADAMTS2 OTTK22NO Strong Biomarker [237]
ADSS2 OTW26XXB Strong Biomarker [238]
ALDH7A1 OTV57BZD Strong Altered Expression [239]
AMELX OTIN26MM Strong Biomarker [240]
ANOS1 OTZJT4KN Strong Biomarker [241]
ANP32B OT3SQMLU Strong Altered Expression [242]
ARHGEF5 OTUVGFT9 Strong Genetic Variation [227]
ASTN1 OT23FQIB Strong Biomarker [243]
BCL11B OT8KKCVJ Strong Biomarker [244]
C1QL1 OTNQ0G3E Strong Biomarker [245]
C2orf49 OTIR8URJ Strong Genetic Variation [246]
CABIN1 OT4G5CIK Strong Biomarker [247]
CASP14 OTKY93H9 Strong Altered Expression [248]
CCDC80 OTOZSYEM Strong Biomarker [249]
CCL1 OT23NON8 Strong Biomarker [68]
CCL13 OTNX0JD0 Strong Biomarker [111]
CCL18 OT7JYSK9 Strong Altered Expression [218]
CCL24 OT9LGHV0 Strong Biomarker [116]
CCL27 OTUZYC61 Strong Biomarker [250]
CCL7 OTDIS99H Strong Biomarker [111]
CD207 OTI9RUDN Strong Biomarker [251]
CD48 OT83ZNPP Strong Biomarker [252]
CD79A OTOJC8DV Strong Biomarker [253]
CDKAL1 OTA0SGNE Strong Genetic Variation [254]
CERS3 OTKCEPYQ Strong Altered Expression [255]
CERS4 OTV5ENAX Strong Altered Expression [256]
CETN1 OTGQ8JOZ Strong Altered Expression [257]
CKLF OTHLPHA0 Strong Altered Expression [258]
CLDN1 OT27KV99 Strong Biomarker [221]
CLDN3 OT71MN9S Strong Altered Expression [259]
CLDN7 OTNE0XHQ Strong Biomarker [221]
CLEC10A OTD8HQT6 Strong Biomarker [162]
CLEC16A OTLGV5SV Strong Genetic Variation [136]
CLEC7A OTRTBH27 Strong Biomarker [260]
COL6A5 OTJT8O80 Strong Biomarker [261]
COL6A6 OT4MVGRW Strong Genetic Variation [262]
COLQ OT4BHUGQ Strong Genetic Variation [263]
CRISPLD2 OTVSFHTL Strong Biomarker [183]
CRNN OTAORBR4 Strong Altered Expression [264]
CST6 OTZVHJTF Strong Altered Expression [121]
CSTA OT1K68KE Strong Genetic Variation [265]
CTRL OTB6NA5O Strong Genetic Variation [266]
DCD OTV5PBGJ Strong Altered Expression [267]
DDX39B OTEVCFVU Strong Genetic Variation [268]
DEFB1 OT5SV0E4 Strong Genetic Variation [269]
DEFB103B OT8RWY64 Strong Altered Expression [270]
DESI1 OTFNIW98 Strong Biomarker [271]
DMKN OTRIGZMK Strong Biomarker [272]
DSC1 OTNII6GZ Strong Biomarker [273]
EFHC1 OTS9IBNE Strong Genetic Variation [132]
EFHD2 OTM9VMN3 Strong Altered Expression [274]
EGR2 OTAVQ78J Strong Altered Expression [275]
EMCN OTS03CZC Strong Altered Expression [276]
EMSY OTBQ3KQE Strong Biomarker [157]
FA2H OT8HA13U Strong Altered Expression [277]
FAF2 OTE8CE2E Strong Altered Expression [278]
FAM177A1 OTXTA14N Strong Genetic Variation [136]
FAR1 OTLHTYIE Strong Genetic Variation [279]
FAR2 OTRYY709 Strong Biomarker [280]
FIP1L1 OTF91GTL Strong Biomarker [281]
FLAD1 OTY8R02L Strong Genetic Variation [163]
FLG2 OTIIKCFS Strong Altered Expression [229]
FLVCR1 OT9XCFOC Strong Biomarker [282]
FOSB OTW6C05J Strong Altered Expression [283]
HCLS1 OTX7WGYN Strong Altered Expression [284]
HRNR OT560QR5 Strong Altered Expression [285]
IFITM2 OTAT6TI6 Strong Altered Expression [217]
IFNGR1 OTCTQBWW Strong Genetic Variation [286]
IL10RA OTOX3D1D Strong Altered Expression [287]
IL12RB1 OTM1IJO2 Strong Biomarker [178]
IL26 OT2WYCW4 Strong Biomarker [288]
IL9R OTILCLXA Strong Altered Expression [289]
IRF2 OTAZRUW3 Strong Genetic Variation [290]
ITLN1 OT7ZLJVV Strong Altered Expression [291]
IVL OT4VPNGY Strong Altered Expression [292]
JCHAIN OTR8M5TX Strong Altered Expression [293]
JUNB OTG2JXV5 Strong Altered Expression [283]
JUND OTNKACJD Strong Altered Expression [283]
KIDINS220 OTLBH2MA Strong Genetic Variation [294]
KIF3A OTMUBSSK Strong Genetic Variation [132]
KLK11 OT5PKX7Y Strong Altered Expression [295]
KPRP OTRJF3OY Strong Biomarker [296]
KRT10 OTSVRD3Q Strong Altered Expression [297]
KRT14 OTUVZ1DW Strong Biomarker [298]
KRT16 OTGA0EQN Strong Genetic Variation [299]
LXN OTZQ2M6Y Strong Biomarker [300]
MARCO OT0NW2Q0 Strong Altered Expression [301]
MCUB OTXLLSIZ Strong Altered Expression [217]
MYDGF OT9HRPL6 Strong Biomarker [140]
NAP1L2 OT8QI4GF Strong Biomarker [302]
NAT9 OT4ZKCRS Strong Genetic Variation [303]
NEUROD1 OTZQ7QJ2 Strong Biomarker [101]
NFKBIZ OTU728KS Strong Biomarker [304]
NLRP10 OTDNZDA0 Strong Genetic Variation [249]
NPL OTA7P0TO Strong Genetic Variation [305]
NPNT OTFZAO1G Strong Genetic Variation [306]
NPTN OTAQKSAU Strong Biomarker [307]
OAS2 OT64CCTM Strong Altered Expression [308]
OGA OT7ZBWT1 Strong Biomarker [309]
ORM1 OTZKSBRE Strong Biomarker [83]
PCDH1 OT7KDEL3 Strong Genetic Variation [310]
PDC OT1UUVYY Strong Biomarker [311]
PDZK1IP1 OTWA6M5K Strong Biomarker [172]
PFDN4 OT5NRHER Strong Genetic Variation [249]
PHF11 OT5F6LUP Strong Genetic Variation [312]
PI3 OT47MTC3 Strong Biomarker [313]
PIAS1 OTZVAHZI Strong Altered Expression [314]
PKP2 OTJOVF68 Strong Genetic Variation [315]
PLA2G4D OTKBAB0F Strong Altered Expression [316]
PLCB3 OT0OMDEM Strong Altered Expression [317]
PLD3 OTL07SP2 Strong Biomarker [318]
PLXNB2 OT56I2VD Strong Altered Expression [319]
PPBP OT1FHGQS Strong Altered Expression [320]
PPP2R3C OT7E6V9B Strong Genetic Variation [136]
PRKAG2 OTHTAM54 Strong Genetic Variation [321]
PRKRA OTUTVZZU Strong Genetic Variation [82]
PRPF40A OT6EXJZN Strong Genetic Variation [322]
PRR5L OTQ1Z0OU Strong Genetic Variation [136]
PRSS3 OTN3S5YB Strong Genetic Variation [154]
PSENEN OTJ7M7G9 Strong Biomarker [302]
PTPRD OTZPJ3GX Strong Genetic Variation [323]
PUS10 OTFFJWZX Strong Genetic Variation [136]
RAB31 OTMLXQZ0 Strong Genetic Variation [217]
RAD50 OTYMU9G1 Strong Genetic Variation [324]
RAPSN OTGMSWDQ Strong Genetic Variation [163]
RELB OTU3QYEF Strong Biomarker [325]
RGCC OTYJMLWM Strong Altered Expression [326]
RHCE OTS18IZ5 Strong Biomarker [281]
RNASE3 OTVE2XD1 Strong Biomarker [234]
RNASE7 OTIXO0Z4 Strong Altered Expression [327]
RNF111 OTO3QT6Q Strong Genetic Variation [328]
RPS20 OTI8052R Strong Biomarker [329]
RPTN OTOAA25U Strong Altered Expression [264]
RTEL1 OTI3PJCT Strong Genetic Variation [136]
S100A7 OTJFVJRF Strong Altered Expression [327]
SAA2 OTYAVJWG Strong Altered Expression [330]
SBSN OT89RKJH Strong Biomarker [331]
SDF4 OTQ7WFYW Strong Altered Expression [257]
SEMA4A OT8901H3 Strong Biomarker [332]
SERPINB4 OT88LHZ8 Strong Biomarker [333]
SETBP1 OTKGCOSR Strong Biomarker [334]
SH2B1 OTJZO2CI Strong Altered Expression [314]
SHARPIN OTU1J2KH Strong Biomarker [335]
SIGLEC7 OTNDLURR Strong Altered Expression [284]
SLC35G1 OTKZUA8O Strong Biomarker [271]
SMIM10L2B OT04IG2N Strong Biomarker [336]
SOCS5 OTN1ABYR Strong Altered Expression [337]
SOSTDC1 OTAKDNSM Strong Biomarker [338]
SPINK6 OTYKZANJ Strong Altered Expression [339]
SPRR3 OTN9QJKG Strong Biomarker [229]
SRL OT7IEBWZ Strong Altered Expression [150]
TAC1 OTM842YW Strong Altered Expression [340]
TBC1D4 OTK66C40 Strong Altered Expression [341]
TBCA OTCCWMGK Strong Genetic Variation [342]
TCHH OT4J7EFT Strong Genetic Variation [268]
TCN1 OTW6A49Y Strong Biomarker [300]
TIMD4 OTGGC20G Strong Biomarker [227]
TLCD3B OTM6EPUS Strong Biomarker [343]
TMEM79 OTEC6EFU Strong Genetic Variation [344]
TNFSF18 OT3ANRX1 Strong Biomarker [193]
TNFSF8 OTDYGDJ3 Strong Biomarker [345]
TNIP1 OTRAOTEW Strong Genetic Variation [82]
TOX OTE8BL5Z Strong Biomarker [346]
TRAF3IP2 OTLLZERL Strong Biomarker [347]
TRAT1 OTMPUNPD Strong Altered Expression [348]
TRIM32 OTJOV0PG Strong Biomarker [348]
TSBP1 OT5GE8IO Strong Genetic Variation [249]
CXCL17 OTRCEVIZ Definitive Altered Expression [349]
IL17C OTKXIVNQ Definitive Biomarker [350]
PLA2G2E OTGJ5XJR Definitive Altered Expression [351]
------------------------------------------------------------------------------------
⏷ Show the Full List of 227 DOT(s)

References

1 FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 213871.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5171).
4 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
5 ClinicalTrials.gov (NCT00745199) Evaluating the Effect of Cromolyn Sodium in Uremic Pruritus. U.S. National Institutes of Health.
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7066).
7 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
8 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6783).
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
10 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6962).
11 ClinicalTrials.gov (NCT01359943) Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate
12 ClinicalTrials.gov (NCT02564042) A Dose-Finding Study of GSK2894512 Cream in Subjects With Plaque Psoriasis.
13 FDA Approved Drug Products from FDA Official Website. 2021. Application Number: 761180.
14 ClinicalTrials.gov (NCT04804605) Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-OLE). U.S. National Institutes of Health.
15 ClinicalTrials.gov (NCT05614817) A Randomized, Double-blind, Placebo-controlled Phase 3 Trial to Evaluate the Efficacy and Safety of CBP-201 Monotherapy in Patients With Moderate-To-Severe Atopic Dermatitis Who Are Candidates for Systemic Therapy. U.S.National Institutes of Health.
16 ClinicalTrials.gov (NCT03989206) Long-term Safety and Efficacy of Nemolizumab With Moderate-to-severe Atopic Dermatitis. U.S. National Institutes of Health.
17 ClinicalTrials.gov (NCT05633355) A Phase 3, Open-label, 52-week Study to Assess the Safety, Tolerability, and Efficacy of Rocatinlimab (AMG 451) in Adolescent Subjects Aged >= 12 to < 18 Years With Moderate-to-severe Atopic Dermatitis (AD) (ROCKET-Orbit). U.S.National Institutes of Health.
18 ClinicalTrials.gov (NCT02134028) Long-Term Safety Evaluation of Dupilumab in Patients With Asthma. U.S. National Institutes of Health.
19 Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.
20 ClinicalTrials.gov (NCT05509023) A Randomized, Double-Blind, Placebo-Controlled Phase 2a Proof-of-Concept Study Evaluating the Safety and Efficacy of ADX-914 in Subjects With Moderate to Severe Atopic Dermatitis. U.S.National Institutes of Health.
21 OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis-Focus on Rocatinlimab and Amlitelimab. Pharmaceutics. 2022 Dec 8;14(12):2753.
22 ClinicalTrials.gov (NCT01301508) Efficacy and Safety of AN2898 and AN2728 Topical Ointments to Treat Mild-to-Moderate Atopic Dermatitis. U.S. National Institutes of Health.
23 Clinical pipeline report, company report or official report of Anacor Pharmaceuticals.
24 ClinicalTrials.gov (NCT01756898) A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of ASB17061 Capsules in Adult Subjects With Atopic Dermatitis. U.S. National Institutes of Health.
25 ClinicalTrials.gov (NCT03759340) ATI-502 Topical Solution for the Treatment of Alopecia Areata (AA), Alopecia Universalis (AU) and Alopecia Totalis (AT). U.S. National Institutes of Health.
26 ClinicalTrials.gov (NCT00883311) A Study of BRT-FC-83C for the Treatment of Atopic Dermatitis. U.S. National Institutes of Health.
27 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024035)
28 ClinicalTrials.gov (NCT01447017) A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis. U.S. National Institutes of Health.
29 ClinicalTrials.gov (NCT01461941) A Phase 2 Study of E6005 in Patients With Atopic Dermatitis. U.S. National Institutes of Health.
30 ClinicalTrials.gov (NCT01299610) A Study to Test the Effect of 2 Different Doses of Topical GW870086X on Atopic Dermatitis Also Including a Postive Control and a Placebo. U.S. National Institutes of Health.
31 ClinicalTrials.gov (NCT01568489) Phase 2 Study of HL-009 Liposomal Gel to Treat Mild to Moderate Atopic Dermatitis. U.S. National Institutes of Health.
32 ClinicalTrials.gov (NCT00455429) An Efficacy and Safety Study of JNJ-26113100 in the Treatment of Adult Atopic Dermatitis. U.S. National Institutes of Health.
33 ClinicalTrials.gov (NCT01067833) Phase 2 Study of Oral K201 for Prevention of AF Recurrence. U.S. National Institutes of Health.
34 ClinicalTrials.gov (NCT01119339) Study to Investigate Dose-related Efficacy of LAS41004 in the Treatment of Psoriasis. U.S. National Institutes of Health.
35 ClinicalTrials.gov (NCT01037881) LEO 29102 Cream in the Treatment of Atopic Dermatitis. U.S. National Institutes of Health.
36 Clinical pipeline report, company report or official report of NicOx SA.
37 ClinicalTrials.gov (NCT02052531) Efficacy and Safety Study of PAC-14028 Cream in Dermal Pruritus. U.S. National Institutes of Health.
38 ClinicalTrials.gov (NCT05375955) A PHASE 2B, RANDOMIZED, DOUBLE BLIND, VEHICLE CONTROLLED, PARALLEL GROUP STUDY TO ASSESS THE EFFICACY, SAFETY, TOLERABILITY AND PHARMACOKINETICS OF MULTIPLE DOSE LEVELS OF PF-07038124 OINTMENT FOR 12 WEEKS IN PARTICIPANTS 12 YEARS AND OLDER AND WITH MILD-TO-MODERATE ATOPIC DERMATITIS OR MILD-TO-SEVERE PLAQUE PSORIASIS. U.S.National Institutes of Health.
39 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 579).
40 ClinicalTrials.gov (NCT03571620) Safety and Efficacy Study of Q301 in Mild to Moderate Adolescents and Adults Atopic Dermatitis Patients. U.S. National Institutes of Health.
41 Emerging drugs for atopic dermatitis. Expert Opin Emerg Drugs. 2009 Mar;14(1):165-79.
42 ClinicalTrials.gov (NCT04992546) A Randomized, Intra-patient, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Topically Administered PRN473 (SAR444727) in Patients With Mild to Moderate Atopic Dermatitis. U.S.National Institutes of Health.
43 ClinicalTrials.gov (NCT00882245) Safety and Efficacy of SRD441 Ointment in Patients With Atopic Dermatitis. U.S. National Institutes of Health.
44 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024588)
45 ClinicalTrials.gov (NCT00914186) Study of TS-022 in Adult Patients With Atopic Dermatitis With Pruritus (POC). U.S. National Institutes of Health.
46 ClinicalTrials.gov (NCT05277571) A Phase 1/2A, Randomized, Placebo-Controlled, Single-Ascending Dose (Part A, Participant- and Investigator-Blind) and Repeat-Dose (Part B, Participant-, Investigator-, and Sponsor-Blind) Study to Investigate the Safety, Pharmacokinetics, and Efficacy (Part B Only) of UCB1381 in Healthy Study Participants (Part A) and in Study Participants With Moderate to Severe Atopic Dermatitis (Part B). U.S.National Institutes of Health.
47 ClinicalTrials.gov (NCT05656911) A Randomized, Placebo-controlled, Double-blind, Parallel-group, Multicenter Phase 2a Study to Investigate Efficacy and Safety of Zabedosertib (BAY 1834845) for the Treatment of Adult Patients With Moderate-to-severe Atopic Dermatitis. U.S.National Institutes of Health.
48 ClinicalTrials.gov (NCT00932074) A Study to Determine the Safety, Tolerability and Efficacy of KP 13 in Subjects With Atopic Dermatitis(AD). U.S. National Institutes of Health.
49 ClinicalTrials.gov (NCT01605708) Study to Assess the Clinical Activity of a Sequential Dose of REGN846 on Refractory Pruritus in Patients With Atopic Dermatitis. U.S. National Institutes of Health.
50 ClinicalTrials.gov (NCT04668066) A PHASE 1 FIRST IN HUMAN, RANDOMIZED, DOUBLE BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, SINGLE- AND MULTIPLE DOSE ESCALATION, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF PF 07242813 IN HEALTHY PARTICIPANTS AND PARTICIPANTS WITH ATOPIC DERMATITIS. U.S.National Institutes of Health.
51 ClinicalTrials.gov (NCT05496738) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, DOSE-ESCALATING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SINGLE AND MULTIPLE INTRAVENOUS AND SUBCUTANEOUS DOSES OF PF-07264660 IN HEALTHY PARTICIPANTS. U.S.National Institutes of Health.
52 ClinicalTrials.gov (NCT05411588) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR OPEN, PLACEBO-CONTROLLED, DOSE ESCALATING STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF SINGLE AND MULTIPLE INTRAVENOUS AND SUBCUTANEOUS DOSES OF PF-07275315 IN HEALTHY PARTICIPANTS. U.S.National Institutes of Health.
53 ClinicalTrials.gov (NCT05206604) A PHASE 1, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, VEHICLE-CONTROLLED, FIRST-IN-HUMAN, MULTIPLE-DOSE STUDY, TO INVESTIGATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS, OF TOPICALLY ADMINISTERED PF-07295324 AND PF-07259955, IN HEALTHY ADULT PARTICIPANTS. U.S.National Institutes of Health.
54 Clinical pipeline report, company report or official report of Sanofi
55 Clinical pipeline report, company report or official report of Siolta Therapeutics.
56 ClinicalTrials.gov (NCT04643457) A Phase I/IIA, Randomized, Placebo-Controlled, Single-Ascending Dose (Part A, Participant- and Investigator-Blind) and Repeated-Dose (Part B, Participant-, Investigator-, and Sponsor-Blind) Study to Investigate the Safety, Pharmacokinetics, and Efficacy of UCB9741 in Healthy Study Participants (Part A) and in Study Participants With Moderate-to-Severe Atopic Dermatitis (Part B). U.S.National Institutes of Health.
57 Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).Expert Opin Ther Pat. 2016;26(4):471-83.
58 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006996)
59 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014452)
60 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018071)
61 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008118)
62 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 282).
63 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
64 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2372).
65 Effect of orally administered KF66490, a phosphodiesterase 4 inhibitor, on dermatitis in mouse models. Int Immunopharmacol. 2009 Jan;9(1):55-62.
66 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767).
67 Methyl--cyclodextrin treatment combined to incubation with interleukin-4 reproduces major features of atopic dermatitis in a 3D-culture model.Arch Dermatol Res. 2017 Jan;309(1):63-69. doi: 10.1007/s00403-016-1699-7. Epub 2016 Nov 11.
68 A Molluscum contagiosum fusion protein inhibits CCL1-induced chemotaxis of cells expressing CCR8 and penetrates human neonatal foreskins: clinical applications proposed.Arch Dermatol Res. 2015 Apr;307(3):275-80. doi: 10.1007/s00403-014-1516-0. Epub 2014 Nov 11.
69 CD1a presentation of endogenous antigens by group 2 innate lymphoid cells.Sci Immunol. 2017 Dec 22;2(18):eaan5918. doi: 10.1126/sciimmunol.aan5918.
70 Regulation of claudin-4 via p63 in human epithelial cells.Ann N Y Acad Sci. 2017 Oct;1405(1):25-31. doi: 10.1111/nyas.13456. Epub 2017 Aug 30.
71 Human Adipose Tissue-Derived Mesenchymal Stem Cells Attenuate Atopic Dermatitis by Regulating the Expression of MIP-2, miR-122a-SOCS1 Axis, and Th1/Th2 Responses.Front Pharmacol. 2018 Nov 6;9:1175. doi: 10.3389/fphar.2018.01175. eCollection 2018.
72 A Promoter Polymorphism of the Vitamin D Metabolism Gene Cyp24a1 is Associated with Severe Atopic Dermatitis in Adults.Acta Derm Venereol. 2016 Feb;96(2):169-72. doi: 10.2340/00015555-2226.
73 Thymic stromal lymphopoietin epigenetically upregulates Fc receptor subunit-related receptors on antigen-presenting cells and induces T(H)2/T(H)17 polarization through dectin-2.J Allergy Clin Immunol. 2019 Oct;144(4):1025-1035.e7. doi: 10.1016/j.jaci.2019.06.011. Epub 2019 Jun 25.
74 Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis.J Invest Dermatol. 2002 Oct;119(4):870-5. doi: 10.1046/j.1523-1747.2002.00191.x.
75 MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase.Cell Mol Biol (Noisy-le-grand). 2018 Feb 28;64(3):103-107. doi: 10.14715/cmb/2018.64.3.17.
76 Disparity of innate immunity-related gene effects on asthma and allergy on Karelia.Pediatr Allergy Immunol. 2011 Sep;22(6):621-30. doi: 10.1111/j.1399-3038.2011.01186.x. Epub 2011 Jul 13.
77 Association of polymorphisms in genes encoding IL-4, IL-13 and their receptors with atopic dermatitis in a Korean population.Exp Dermatol. 2011 Nov;20(11):915-9. doi: 10.1111/j.1600-0625.2011.01357.x. Epub 2011 Sep 14.
78 Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13R2 in Keratinocytes.Int J Mol Sci. 2019 Jul 6;20(13):3324. doi: 10.3390/ijms20133324.
79 Interleukin-33 serum levels in postmenopausal women with osteoporosis.Sci Rep. 2019 Mar 7;9(1):3786. doi: 10.1038/s41598-019-40212-6.
80 Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro.J Eur Acad Dermatol Venereol. 2019 May;33(5):906-911. doi: 10.1111/jdv.15449. Epub 2019 Mar 4.
81 Ustekinumab treatment in severe atopic dermatitis: Down-regulation of T-helper 2/22 expression.J Am Acad Dermatol. 2017 Jan;76(1):91-97.e3. doi: 10.1016/j.jaad.2016.07.047. Epub 2016 Oct 13.
82 Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.Am J Hum Genet. 2015 Jan 8;96(1):104-20. doi: 10.1016/j.ajhg.2014.12.004.
83 Vaccinia virus-specific molecular signature in atopic dermatitis skin.J Allergy Clin Immunol. 2010 Jan;125(1):153-159.e28. doi: 10.1016/j.jaci.2009.10.024.
84 Interaction of NPSR1 genotypes and probiotics in the manifestation of atopic eczema in early childhood.Allergol Immunopathol (Madr). 2014 Nov-Dec;42(6):560-7. doi: 10.1016/j.aller.2013.10.001. Epub 2014 Jan 14.
85 Neurotensin serum levels and skin gene expression are increased in atopic dermatitis.Br J Dermatol. 2013 Sep;169(3):695-9. doi: 10.1111/bjd.12413.
86 Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation.Pharm Biol. 2017 Dec;55(1):1324-1329. doi: 10.1080/13880209.2017.1300819.
87 Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor.Toxins (Basel). 2018 Apr 2;10(4):146. doi: 10.3390/toxins10040146.
88 Usefulness of a global clinical ichthyosis vulgaris scoring system for predicting common FLG null mutations in an adult caucasian population.Br J Dermatol. 2012 Nov;167(5):1165-9. doi: 10.1111/j.1365-2133.2012.11062.x. Epub 2012 Sep 7.
89 PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.PLoS One. 2012;7(3):e33329. doi: 10.1371/journal.pone.0033329. Epub 2012 Mar 19.
90 Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans.J Dermatol Sci. 2007 May;46(2):143-6. doi: 10.1016/j.jdermsci.2006.12.001. Epub 2007 Jan 8.
91 Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis.J Allergy Clin Immunol. 1995 Dec;96(6 Pt 2):1051-60. doi: 10.1016/s0091-6749(95)70190-7.
92 Association of thromboxane A2 receptor (TBXA2R) gene polymorphism in patients with aspirin-intolerant acute urticaria.Clin Exp Allergy. 2011 Feb;41(2):179-85. doi: 10.1111/j.1365-2222.2010.03642.x. Epub 2010 Nov 11.
93 LIGHT-HVEM signaling in keratinocytes controls development of dermatitis.J Exp Med. 2018 Feb 5;215(2):415-422. doi: 10.1084/jem.20170536. Epub 2018 Jan 16.
94 The Immunosuppressant Macrolide Tacrolimus Activates Cold-Sensing TRPM8 Channels.J Neurosci. 2019 Feb 6;39(6):949-969. doi: 10.1523/JNEUROSCI.1726-18.2018. Epub 2018 Dec 13.
95 Serum IL-21 levels are elevated in atopic dermatitis patients with acute skin lesions.Allergol Int. 2017 Jul;66(3):440-444. doi: 10.1016/j.alit.2016.10.010. Epub 2016 Nov 22.
96 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
97 Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis.Immunopharmacol Immunotoxicol. 2018 Oct;40(5):401-407. doi: 10.1080/08923973.2018.1510964. Epub 2018 Sep 5.
98 Expression of the collagen VI 5 and 6 chains in normal human skin and in skin of patients with collagen VI-related myopathies.J Invest Dermatol. 2011 Jan;131(1):99-107. doi: 10.1038/jid.2010.284. Epub 2010 Sep 30.
99 Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis.Elife. 2019 Oct 21;8:e48448. doi: 10.7554/eLife.48448.
100 Signaling via the IL-20 receptor inhibits cutaneous production of IL-1 and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus.Nat Immunol. 2013 Aug;14(8):804-11. doi: 10.1038/ni.2637. Epub 2013 Jun 23.
101 Activation of RhoA, Smad2, c-Src, PKC-II/ and JNK in atopic dermatitis.Australas J Dermatol. 2018 Nov;59(4):e258-e261. doi: 10.1111/ajd.12801. Epub 2018 Mar 2.
102 ZAG Regulates the Skin Barrier and Immunity in Atopic Dermatitis.J Invest Dermatol. 2019 Aug;139(8):1648-1657.e7. doi: 10.1016/j.jid.2019.01.023. Epub 2019 Feb 6.
103 ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children.Clin Biochem. 2009 Apr;42(6):477-83. doi: 10.1016/j.clinbiochem.2008.12.014. Epub 2008 Dec 31.
104 Intermedin: a skin peptide that is downregulated in atopic dermatitis.J Invest Dermatol. 2007 Mar;127(3):605-13. doi: 10.1038/sj.jid.5700576. Epub 2006 Sep 28.
105 Transcriptomic and lipidomic profiling of eicosanoid/docosanoid signalling in affected and non-affected skin of human atopic dermatitis patients.Exp Dermatol. 2019 Feb;28(2):177-189. doi: 10.1111/exd.13867.
106 An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammation.PLoS One. 2013 Nov 8;8(11):e80179. doi: 10.1371/journal.pone.0080179. eCollection 2013.
107 Nonclinical Safety and Toxicokinetics of MnTE-2-PyP (BMX-010), a Topical Agent in Phase 2 Trials for Psoriasis and Atopic Dermatitis.Int J Toxicol. 2019 Jul/Aug;38(4):291-302. doi: 10.1177/1091581819852325.
108 Glyoxal-induced exacerbation of pruritus and dermatitis is associated with staphylococcus aureus colonization in the skin of a rat model of atopic dermatitis.J Dermatol Sci. 2018 Jun;90(3):276-283. doi: 10.1016/j.jdermsci.2018.02.012. Epub 2018 Feb 21.
109 Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin.Molecules. 2019 Apr 15;24(8):1484. doi: 10.3390/molecules24081484.
110 Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8.Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22249-54. doi: 10.1073/pnas.1009751108. Epub 2010 Dec 6.
111 Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis.Ann Allergy Asthma Immunol. 2020 Jan;124(1):70-78. doi: 10.1016/j.anai.2019.10.013. Epub 2019 Oct 14.
112 Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients.Ann Allergy Asthma Immunol. 2019 Mar;122(3):318-330.e3. doi: 10.1016/j.anai.2018.11.025. Epub 2018 Dec 1.
113 CCL23 expression is induced by IL-4 in a STAT6-dependent fashion.J Immunol. 2007 Apr 1;178(7):4335-41. doi: 10.4049/jimmunol.178.7.4335.
114 Investigation of Immune-Regulatory Effects of Mageumsan Hot Spring via Protein Microarray In Vitro.Ann Dermatol. 2018 Jun;30(3):322-330. doi: 10.5021/ad.2018.30.3.322. Epub 2018 Apr 23.
115 RANTES gene polymorphisms are not associated with rheumatoid arthritis and atopic dermatitis: a meta-analysis.Int Rev Immunol. 2015;34(6):500-8. doi: 10.3109/08830185.2014.994815. Epub 2015 Jan 21.
116 Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.J Allergy Clin Immunol. 2008 Apr;121(4):962-8.e6. doi: 10.1016/j.jaci.2007.12.1165. Epub 2008 Feb 4.
117 The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis.J Allergy Clin Immunol. 2008 Apr;121(4):1013-9. doi: 10.1016/j.jaci.2007.11.029. Epub 2008 Jan 30.
118 Association study of mast cell chymase polymorphisms with atopy.Allergy. 2005 Oct;60(10):1256-61. doi: 10.1111/j.1398-9995.2005.00879.x.
119 Association of cathepsin E deficiency with development of atopic dermatitis.J Biochem. 2003 Dec;134(6):893-902. doi: 10.1093/jb/mvg216.
120 A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis.J Allergy Clin Immunol. 2017 Apr;139(4):1228-1241. doi: 10.1016/j.jaci.2016.09.052. Epub 2016 Nov 29.
121 The cystatin M/E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis.Br J Dermatol. 2009 Aug;161(2):253-64. doi: 10.1111/j.1365-2133.2009.09156.x. Epub 2009 Apr 24.
122 Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis.J Invest Dermatol. 2008 Jan;128(1):67-78. doi: 10.1038/sj.jid.5700945. Epub 2007 Aug 16.
123 927T>C polymorphism of the cysteinyl-leukotriene type-1 receptor (CYSLTR1) gene in children with asthma and atopic dermatitis.Pediatr Allergy Immunol. 2006 Aug;17(5):323-8. doi: 10.1111/j.1399-3038.2006.00416.x.
124 Update on protease-activated receptor 2 in cutaneous barrier, differentiation, tumorigenesis and pigmentation, and its role in related dermatologic diseases.Exp Dermatol. 2019 Aug;28(8):877-885. doi: 10.1111/exd.13936. Epub 2019 May 15.
125 IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.Sci Rep. 2017 Dec 4;7(1):16847. doi: 10.1038/s41598-017-17307-z.
126 GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.Sci Rep. 2017 Sep 19;7(1):11847. doi: 10.1038/s41598-017-10252-x.
127 Association of Genetic Polymorphisms with Atopic Dermatitis, Clinical Severity and Total IgE: A Replication and Extended Study.Allergy Asthma Immunol Res. 2018 Jul;10(4):397-405. doi: 10.4168/aair.2018.10.4.397.
128 Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis.J Med Chem. 2018 Apr 12;61(7):2949-2961. doi: 10.1021/acs.jmedchem.7b01855. Epub 2018 Apr 3.
129 Neuroimmune mechanisms in patients with atopic dermatitis during chronic stress.J Eur Acad Dermatol Venereol. 2008 Jan;22(1):11-8. doi: 10.1111/j.1468-3083.2007.02202.x.
130 T helper 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of inducible T-cell costimulator.Br J Dermatol. 2020 Mar;182(3):648-657. doi: 10.1111/bjd.18040. Epub 2019 Aug 19.
131 Genetic variations in IL28B and allergic disease in children.PLoS One. 2012;7(1):e30607. doi: 10.1371/journal.pone.0030607. Epub 2012 Jan 25.
132 Meta-analysis identifies seven susceptibility loci involved in the atopic march.Nat Commun. 2015 Nov 6;6:8804. doi: 10.1038/ncomms9804.
133 Inhibition of S100A11 gene expression impairs keratinocyte response against vaccinia virus through downregulation of the IL-10 receptor 2 chain.J Allergy Clin Immunol. 2009 Aug;124(2):270-7, 277.e1. doi: 10.1016/j.jaci.2009.05.002. Epub 2009 Jul 3.
134 Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans.J Dermatol Sci. 2010 Mar;57(3):199-206. doi: 10.1016/j.jdermsci.2009.12.003. Epub 2010 Jan 8.
135 The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins.Sci Rep. 2017 Aug 18;7(1):8707. doi: 10.1038/s41598-017-09207-z.
136 Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.Nat Genet. 2015 Dec;47(12):1449-1456. doi: 10.1038/ng.3424. Epub 2015 Oct 19.
137 Genome-wide association studies of allergic diseases.Allergol Int. 2013 Mar;62(1):21-8. doi: 10.2332/allergolint.13-RAI-0539.
138 IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice.J Clin Invest. 2009 Jan;119(1):47-60. doi: 10.1172/JCI32310. Epub 2008 Dec 15.
139 Pathophysiology of atopic dermatitis: Clinical implications.Allergy Asthma Proc. 2019 Mar 1;40(2):84-92. doi: 10.2500/aap.2019.40.4202.
140 Eupatilin, an activator of PPAR, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.Biochem Biophys Res Commun. 2018 Feb 5;496(2):508-514. doi: 10.1016/j.bbrc.2018.01.098. Epub 2018 Jan 17.
141 Phase 2B randomized study of nemolizumab in adults with moderate-to-severe atopic dermatitis and severe pruritus.J Allergy Clin Immunol. 2020 Jan;145(1):173-182. doi: 10.1016/j.jaci.2019.08.013. Epub 2019 Aug 23.
142 IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis.Int J Mol Sci. 2019 Aug 20;20(16):4053. doi: 10.3390/ijms20164053.
143 Interleukin-32 is highly expressed in lesions of hidradenitis suppurativa.Br J Dermatol. 2017 Nov;177(5):1358-1366. doi: 10.1111/bjd.15458. Epub 2017 Sep 27.
144 Increased interleukin-36 expression in skin and sera of patients with atopic dermatitis and mycosis fungoides/Szary syndrome.J Dermatol. 2018 Apr;45(4):468-471. doi: 10.1111/1346-8138.14198. Epub 2018 Jan 3.
145 Insight into interleukin-37: The potential therapeutic target in allergic diseases.Cytokine Growth Factor Rev. 2019 Oct;49:32-41. doi: 10.1016/j.cytogfr.2019.10.003. Epub 2019 Oct 18.
146 Inflammatory alopecia in patients on dupilumab: a retrospective cohort study at an academic institution.J Eur Acad Dermatol Venereol. 2020 Apr;34(4):e159-e161. doi: 10.1111/jdv.16094. Epub 2019 Dec 20.
147 Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.J Allergy Clin Immunol. 2020 Apr;145(4):1208-1218. doi: 10.1016/j.jaci.2019.10.030. Epub 2019 Nov 9.
148 Th9 Cells in Allergic Disease.Curr Allergy Asthma Rep. 2019 Mar 26;19(5):29. doi: 10.1007/s11882-019-0860-8.
149 Itch gene polymorphisms in healthy population and in patients affected by rheumatoid arthritis and atopic dermatitis.Cell Cycle. 2008 Nov 15;7(22):3607-9. doi: 10.4161/cc.7.22.6968. Epub 2008 Nov 9.
150 Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis.Int Arch Allergy Immunol. 2002 Dec;129(4):327-40. doi: 10.1159/000067589.
151 Treatment of atopic dermatitis with ruxolitinib cream (JAK1/JAK2 inhibitor) or triamcinolone cream.J Allergy Clin Immunol. 2020 Feb;145(2):572-582. doi: 10.1016/j.jaci.2019.08.042. Epub 2019 Oct 17.
152 Superoxide Dismutase 3 Inhibits LL-37/KLK-5-Mediated Skin Inflammation through Modulation of EGFR and Associated Inflammatory Cascades.J Invest Dermatol. 2020 Mar;140(3):656-665.e8. doi: 10.1016/j.jid.2019.08.434. Epub 2019 Aug 26.
153 A proinflammatory role of KLK6 protease in Netherton syndrome.J Dermatol Sci. 2019 Jul;95(1):28-35. doi: 10.1016/j.jdermsci.2019.06.004. Epub 2019 Jun 16.
154 Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation.Allergy. 2020 Feb;75(2):403-411. doi: 10.1111/all.14018. Epub 2019 Sep 9.
155 Screening for key genes associated with atopic dermatitis with DNA microarrays.Mol Med Rep. 2014 Mar;9(3):1049-55. doi: 10.3892/mmr.2014.1908. Epub 2014 Jan 21.
156 Identification of unique proteomic signatures in allergic and non-allergic skin disease.Clin Exp Allergy. 2017 Nov;47(11):1456-1467. doi: 10.1111/cea.12979. Epub 2017 Aug 11.
157 EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis.J Allergy Clin Immunol. 2019 Aug;144(2):470-481. doi: 10.1016/j.jaci.2019.05.024. Epub 2019 May 31.
158 The role of leukotriene B(4) in allergic diseases.Allergol Int. 2008 Dec;57(4):291-8. doi: 10.2332/allergolint.08-RAI-0019. Epub 2008 Dec 1.
159 Lactoferricin/verbascoside topical emulsion: a possible alternative treatment for atopic dermatitis in dogs.Nat Prod Res. 2018 Sep;32(17):2107-2110. doi: 10.1080/14786419.2017.1365066. Epub 2017 Aug 28.
160 The Wiskott-Aldrich syndrome gene as a candidate gene for atopic dermatitis.Acta Derm Venereol. 2001 Oct-Nov;81(5):340-2. doi: 10.1080/000155501317140043.
161 An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90).J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):167-70. doi: 10.1067/mai.2000.107935.
162 Different hypersensitivities against homologous proteins of MGL_1304 in patients with atopic dermatitis.Allergol Int. 2018 Jan;67(1):103-108. doi: 10.1016/j.alit.2017.05.009. Epub 2017 Jun 24.
163 Single Nucleotide Polymorphisms in the FADS Gene Cluster but not the ELOVL2 Gene are Associated with Serum Polyunsaturated Fatty Acid Composition and Development of Allergy (in a Swedish Birth Cohort).Nutrients. 2015 Dec 3;7(12):10100-15. doi: 10.3390/nu7125521.
164 The N-Acylethanolamine Acid Amidase Inhibitor ARN077 Suppresses Inflammation and Pruritus in a Mouse Model of AllergicDermatitis.J Invest Dermatol. 2018 Mar;138(3):562-569. doi: 10.1016/j.jid.2017.07.853. Epub 2017 Oct 18.
165 IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.Mol Cell Biol. 1996 May;16(5):2341-9. doi: 10.1128/MCB.16.5.2341.
166 Targeting PAR2 with Pepducins.J Invest Dermatol. 2019 Feb;139(2):282-284. doi: 10.1016/j.jid.2018.09.008. Epub 2018 Nov 22.
167 Neurotrophin-4 production by human epidermal keratinocytes: increased expression in atopic dermatitis.J Invest Dermatol. 2000 Jun;114(6):1108-12. doi: 10.1046/j.1523-1747.2000.00974.x.
168 Lipid abnormalities in atopic skin are driven by type 2 cytokines.JCI Insight. 2018 Feb 22;3(4):e98006. doi: 10.1172/jci.insight.98006. eCollection 2018 Feb 22.
169 Evaluating crisaborole as a treatment option for atopic dermatitis.Expert Opin Pharmacother. 2019 Jun;20(9):1057-1063. doi: 10.1080/14656566.2019.1604688. Epub 2019 Apr 19.
170 A Novel Catecholopyrimidine Based Small Molecule PDE4B Inhibitor Suppresses Inflammatory Cytokines in Atopic Mice.Front Pharmacol. 2018 May 11;9:485. doi: 10.3389/fphar.2018.00485. eCollection 2018.
171 Phosphodiesterase 7A: a new therapeutic target for alleviating chronic inflammation?.Curr Pharm Des. 2006;12(25):3207-20. doi: 10.2174/138161206778194123.
172 MAP17 is associated with the T-helper cell cytokine-induced down-regulation of filaggrin transcription in human keratinocytes.Exp Dermatol. 2010 Apr;19(4):355-62. doi: 10.1111/j.1600-0625.2009.00902.x. Epub 2009 Jul 8.
173 Evaluation of periostin level for predicting severity and chronicity of childhood atopic dermatitis.Postepy Dermatol Alergol. 2019 Oct;36(5):616-619. doi: 10.5114/ada.2018.79728. Epub 2019 Nov 12.
174 Protective role of peroxisome proliferator-activated receptor agonists in skin barrier and inflammation.Immunobiology. 2018 Mar;223(3):327-330. doi: 10.1016/j.imbio.2017.10.047. Epub 2017 Oct 27.
175 Association of vitamin D receptor gene polymorphisms with severe atopic dermatitis in adults.Br J Dermatol. 2013 Apr;168(4):855-8. doi: 10.1111/bjd.12077. Epub 2013 Mar 13.
176 Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.PLoS One. 2010 Feb 18;5(2):e9258. doi: 10.1371/journal.pone.0009258.
177 Deficient translocation of c-Rel is associated with impaired Th1 cytokine production in T cells from atopic dermatitis patients.Exp Dermatol. 2005 Jan;14(1):17-25. doi: 10.1111/j.0906-6705.2005.00241.x.
178 Atopic dermatitis in African American patients is T(H)2/T(H)22-skewed with T(H)1/T(H)17 attenuation.Ann Allergy Asthma Immunol. 2019 Jan;122(1):99-110.e6. doi: 10.1016/j.anai.2018.08.024. Epub 2018 Sep 14.
179 Association between asthma-related phenotypes and the CC16 A38G polymorphism in an unselected population of young adult Danes.Immunogenetics. 2005 Apr;57(1-2):25-32. doi: 10.1007/s00251-005-0778-2. Epub 2005 Mar 3.
180 Contribution of selectin ligands to eosinophil recruitment into the skin of patients with atopic dermatitis.Eur J Immunol. 2002 May;32(5):1274-81. doi: 10.1002/1521-4141(200205)32:5<1274::AID-IMMU1274>3.0.CO;2-Q.
181 STAT-6-mediated control of P-selectin by substance P and interleukin-4 in human dermal endothelial cells.Am J Pathol. 2006 Aug;169(2):697-707. doi: 10.2353/ajpath.2006.051211.
182 Association of Key Genes and Pathways with Atopic Dermatitis by Bioinformatics Analysis.Med Sci Monit. 2019 Jun 11;25:4353-4361. doi: 10.12659/MSM.916525.
183 Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis.J Allergy Clin Immunol. 2014 Oct;134(4):781-791.e1. doi: 10.1016/j.jaci.2014.05.048. Epub 2014 Aug 15.
184 Association between serotonin transporter gene polymorphisms and childhood asthma.J Asthma. 2013 Dec;50(10):1031-5. doi: 10.3109/02770903.2013.834503. Epub 2013 Sep 25.
185 Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells.Exp Dermatol. 2007 Aug;16(8):661-70. doi: 10.1111/j.1600-0625.2007.00581.x.
186 Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis.J Cell Mol Med. 2018 Jun;22(6):3133-3138. doi: 10.1111/jcmm.13592. Epub 2018 Mar 22.
187 Glyteer, Soybean Tar, Impairs IL-4/Stat6 Signaling in Murine Bone Marrow-Derived Dendritic Cells: The Basis of Its Therapeutic Effect on Atopic Dermatitis.Int J Mol Sci. 2018 Apr 12;19(4):1169. doi: 10.3390/ijms19041169.
188 The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study.Br J Dermatol. 2019 Oct;181(4):733-742. doi: 10.1111/bjd.17932. Epub 2019 May 6.
189 DNA methylation of Th2 lineage determination genes at birth is associated with allergic outcomes in childhood.Clin Exp Allergy. 2017 Dec;47(12):1599-1608. doi: 10.1111/cea.12988. Epub 2017 Aug 31.
190 Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis.PLoS One. 2012;7(11):e49694. doi: 10.1371/journal.pone.0049694. Epub 2012 Nov 26.
191 Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk.Immunol Invest. 2019 Feb;48(2):169-180. doi: 10.1080/08820139.2018.1508228. Epub 2018 Oct 1.
192 The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.Pediatr Infect Dis J. 2014 May;33(5):463-6. doi: 10.1097/INF.0000000000000253.
193 Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis.Acta Derm Venereol. 2006;86(5):393-8. doi: 10.2340/00015555-0118.
194 TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis.Nat Commun. 2017 May 22;8:15395. doi: 10.1038/ncomms15395.
195 Nonhistaminergic and mechanical itch sensitization in atopic dermatitis.Pain. 2017 Sep;158(9):1780-1791. doi: 10.1097/j.pain.0000000000000980.
196 Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase IIb randomized trial.Br J Dermatol. 2019 May;180(5):1030-1038. doi: 10.1111/bjd.17455. Epub 2019 Jan 8.
197 Inhibition of the Warm Temperature-Activated Ca(2+)-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis.Mol Pharmacol. 2019 Sep;96(3):393-400. doi: 10.1124/mol.119.116962. Epub 2019 Jul 15.
198 Development of a new eczema-like reconstructed skin equivalent for testing child atopic dermatitis-relieving cosmetics.J Cosmet Dermatol. 2020 Mar;19(3):752-757. doi: 10.1111/jocd.13069. Epub 2019 Jul 17.
199 Down-regulation of vasoactive intestinal polypeptide receptor expression in atopic dermatitis.J Allergy Clin Immunol. 2003 May;111(5):1099-105. doi: 10.1067/mai.2003.1477.
200 Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay.Sci Rep. 2019 Mar 26;9(1):5211. doi: 10.1038/s41598-019-41609-z.
201 Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.Clin Sci (Lond). 2006 May;110(5):503-24. doi: 10.1042/CS20050273.
202 Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment.PLoS One. 2018 Apr 20;13(4):e0195960. doi: 10.1371/journal.pone.0195960. eCollection 2018.
203 A rare variant in CYP27A1 and its association with atopic dermatitis with high serum total IgE.Allergy. 2016 Oct;71(10):1486-9. doi: 10.1111/all.12950. Epub 2016 Aug 3.
204 Glycoproteomic studies of IgE from a novel hyper IgE syndrome linked to PGM3 mutation.Glycoconj J. 2016 Jun;33(3):447-56. doi: 10.1007/s10719-015-9638-y. Epub 2015 Dec 19.
205 Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis.J Invest Dermatol. 2012 Apr;132(4):1103-10. doi: 10.1038/jid.2011.412. Epub 2011 Dec 15.
206 Transglutaminase 3 Promotes Skin Inflammation in Atopic Dermatitis by Activating Monocyte-Derived Dendritic Cells via DC-SIGN.J Invest Dermatol. 2020 Feb;140(2):370-379.e8. doi: 10.1016/j.jid.2019.07.703. Epub 2019 Aug 16.
207 Bleomycin hydrolase is regulated biphasically in a differentiation- and cytokine-dependent manner: relevance to atopic dermatitis. J Biol Chem. 2011 Mar 11;286(10):8204-12.
208 Sweat lipid mediator profiling: a noninvasive approach for cutaneous research.J Lipid Res. 2017 Jan;58(1):188-195. doi: 10.1194/jlr.M071738. Epub 2016 Nov 8.
209 Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation.J Pharmacol Sci. 2018 Jan;136(1):9-15. doi: 10.1016/j.jphs.2017.11.002. Epub 2017 Nov 10.
210 Predicting therapy response to mycophenolic acid using UGT1A9 genotyping: towards personalized medicine in atopic dermatitis.J Dermatolog Treat. 2017 May;28(3):242-245. doi: 10.1080/09546634.2016.1227420. Epub 2016 Sep 13.
211 Apamin inhibits TNF-- and IFN--induced inflammatory cytokines and chemokines via suppressions of NF-B signaling pathway and STAT in human keratinocytes.Pharmacol Rep. 2017 Oct;69(5):1030-1035. doi: 10.1016/j.pharep.2017.04.006. Epub 2017 Apr 18.
212 Lactobacillus plantarum NCIMB8826 ameliorates inflammation of colon and skin in human APOC1 transgenic mice.Benef Microbes. 2016;7(2):215-25. doi: 10.3920/BM2015.0074. Epub 2015 Dec 21.
213 Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2.J Dermatolog Treat. 2020 Sep;31(6):606-614. doi: 10.1080/09546634.2019.1612836. Epub 2019 Jun 9.
214 Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.J Invest Dermatol. 2009 Sep;129(9):2148-55. doi: 10.1038/jid.2009.49. Epub 2009 Mar 12.
215 CARD11 is dispensable for homeostatic responses and suppressive activity of peripherally induced FOXP3(+) regulatory T cells.Immunol Cell Biol. 2019 Sep;97(8):740-752. doi: 10.1111/imcb.12268. Epub 2019 Jun 26.
216 IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.Mol Immunol. 2012 Feb;50(1-2):91-7. doi: 10.1016/j.molimm.2011.12.008. Epub 2012 Jan 5.
217 Mechanisms of IFN--induced apoptosis of human skin keratinocytes in patients with atopic dermatitis.J Allergy Clin Immunol. 2012 May;129(5):1297-306. doi: 10.1016/j.jaci.2012.02.020. Epub 2012 Mar 24.
218 CD1c+ Blood Dendritic Cells in Atopic Dermatitis are Premature and Can Produce Disease-specific Chemokines.Acta Derm Venereol. 2017 Mar 10;97(3):325-331. doi: 10.2340/00015555-2540.
219 Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition.J Dermatol. 2018 May;45(5):554-559. doi: 10.1111/1346-8138.14277. Epub 2018 Mar 3.
220 Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis.J Allergy Clin Immunol. 2019 Oct;144(4):1011-1024. doi: 10.1016/j.jaci.2019.07.013. Epub 2019 Jul 26.
221 Oral treatment with Aloe polysaccharide ameliorates ovalbumin-induced atopic dermatitis by restoring tight junctions in skin.Scand J Immunol. 2020 Mar;91(3):e12856. doi: 10.1111/sji.12856. Epub 2019 Dec 19.
222 Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis.J Invest Dermatol. 2016 Dec;136(12):2340-2341. doi: 10.1016/j.jid.2016.08.020.
223 Differential expression of CRABP II, psoriasin and cytokeratin 1 mRNA in human skin diseases.Arch Dermatol Res. 1996 Jul;288(8):426-30. doi: 10.1007/BF02505229.
224 Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.J Allergy Clin Immunol. 2017 Nov;140(5):1310-1322.e5. doi: 10.1016/j.jaci.2017.01.025. Epub 2017 Feb 24.
225 Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population.Hum Immunol. 2012 Mar;73(3):301-5. doi: 10.1016/j.humimm.2011.12.001. Epub 2011 Dec 11.
226 miR-10a-5p is increased in atopic dermatitis and has capacity to inhibit keratinocyte proliferation.Allergy. 2019 Nov;74(11):2146-2156. doi: 10.1111/all.13849. Epub 2019 Jun 6.
227 Genetic association studies between the T cell immunoglobulin mucin (TIM) gene locus and childhood atopic dermatitis.Int Arch Allergy Immunol. 2006;141(4):331-6. doi: 10.1159/000095459. Epub 2006 Aug 29.
228 The Major Orphan Forms of Ichthyosis Are Characterized by Systemic T-Cell Activation and Th-17/Tc-17/Th-22/Tc-22 Polarization in Blood.J Invest Dermatol. 2018 Oct;138(10):2157-2167. doi: 10.1016/j.jid.2018.03.1523. Epub 2018 Apr 14.
229 Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.Acta Derm Venereol. 2017 Jan 4;97(1):36-41. doi: 10.2340/00015555-2482.
230 Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.Clin Immunol. 2008 Mar;126(3):332-7. doi: 10.1016/j.clim.2007.11.006. Epub 2007 Dec 31.
231 Prediction of atopic dermatitis in 2-yr-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy.Pediatr Allergy Immunol. 2011 Nov;22(7):695-703. doi: 10.1111/j.1399-3038.2011.01177.x. Epub 2011 May 4.
232 Type 2 helper T-cell cytokines induce morphologic and molecular characteristics of atopic dermatitis in human skin equivalent.Am J Pathol. 2011 May;178(5):2091-9. doi: 10.1016/j.ajpath.2011.01.037.
233 The IL-13-OVOL1-FLG axis in atopic dermatitis.Immunology. 2019 Dec;158(4):281-286. doi: 10.1111/imm.13120. Epub 2019 Oct 1.
234 Eosinophil-derived neurotoxin as a biomarker for disease severity and relapse in recalcitrant atopic dermatitis.Ann Allergy Asthma Immunol. 2017 Nov;119(5):441-445. doi: 10.1016/j.anai.2017.06.022. Epub 2017 Aug 31.
235 Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.Diabetes Metab Res Rev. 2011 Nov;27(8):838-43. doi: 10.1002/dmrr.1259.
236 Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.Gene. 2015 Oct 25;571(2):249-51. doi: 10.1016/j.gene.2015.06.068. Epub 2015 Jun 27.
237 Spontaneous atopic dermatitis due to immune dysregulation in mice lacking Adamts2 and 14.Matrix Biol. 2018 Sep;70:140-157. doi: 10.1016/j.matbio.2018.04.002. Epub 2018 Apr 9.
238 Atopic dermatitis complicated by eczema herpeticum is associated with HLA B7 and reduced interferon--producing CD8+ T cells.Br J Dermatol. 2013 Sep;169(3):700-3. doi: 10.1111/bjd.12382.
239 Phosphodiesterase 4 Inhibitor Therapies for Atopic Dermatitis: Progress and Outlook.Drugs. 2017 Sep;77(13):1389-1397. doi: 10.1007/s40265-017-0784-3.
240 Tezepelumab, an anti-thymic stromal lymphopoietin monoclonal antibody, in the treatment of moderate to severe atopic dermatitis: A randomized phase 2a clinical trial.J Am Acad Dermatol. 2019 Apr;80(4):1013-1021. doi: 10.1016/j.jaad.2018.11.059. Epub 2018 Dec 12.
241 Keratinocyte-derived anosmin-1, an extracellular glycoprotein encoded by the X-linked Kallmann syndrome gene, is involved in modulation of epidermal nerve density in atopic dermatitis.J Dermatol Sci. 2010 Apr;58(1):64-71. doi: 10.1016/j.jdermsci.2010.02.010. Epub 2010 Feb 20.
242 The expression of BAFF, APRIL and TWEAK is altered in eczema skin but not in the circulation of atopic and seborrheic eczema patients.PLoS One. 2011;6(7):e22202. doi: 10.1371/journal.pone.0022202. Epub 2011 Jul 13.
243 Protein tyrosine phosphatase conjugated with a novel transdermal delivery peptide, astrotactin 1-derived peptide recombinant protein tyrosine phosphatase (AP-rPTP), alleviates both atopic dermatitis-like and psoriasis-like dermatitis.J Allergy Clin Immunol. 2018 Jan;141(1):137-151. doi: 10.1016/j.jaci.2017.04.007. Epub 2017 Apr 26.
244 Selective ablation of Ctip2/Bcl11b in epidermal keratinocytes triggers atopic dermatitis-like skin inflammatory responses in adult mice.PLoS One. 2012;7(12):e51262. doi: 10.1371/journal.pone.0051262. Epub 2012 Dec 20.
245 Association between Stress and the HPA Axis in the Atopic Dermatitis.Int J Mol Sci. 2017 Oct 12;18(10):2131. doi: 10.3390/ijms18102131.
246 Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African-American children with severe atopic dermatitis.Exp Dermatol. 2018 Sep;27(9):989-992. doi: 10.1111/exd.13691. Epub 2018 Jun 28.
247 Off-label Uses of Topical Pimecrolimus.J Cutan Med Surg. 2019 Jul/Aug;23(4):442-448. doi: 10.1177/1203475419847950. Epub 2019 May 3.
248 Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis.J Dermatol Sci. 2014 Dec;76(3):231-9. doi: 10.1016/j.jdermsci.2014.09.004. Epub 2014 Sep 30.
249 Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.Nat Genet. 2012 Nov;44(11):1222-6. doi: 10.1038/ng.2438. Epub 2012 Oct 7.
250 Ionizing radiation promotes CCL27 secretion from keratinocytes through the cross talk between TNF- and ROS.J Biochem Mol Toxicol. 2017 Mar;31(3). doi: 10.1002/jbt.21868. Epub 2016 Nov 23.
251 Toll-like receptor 4 attenuates a murine model of atopic dermatitis through inhibition of langerin-positive DCs migration.Exp Dermatol. 2018 Sep;27(9):1015-1022. doi: 10.1111/exd.13698. Epub 2018 Jul 20.
252 The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation.Clin Exp Allergy. 2014 Nov;44(11):1335-46. doi: 10.1111/cea.12422.
253 Temperature-controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open-label, proof-of-concept study.Clin Exp Allergy. 2018 May;48(5):594-603. doi: 10.1111/cea.13105. Epub 2018 Mar 13.
254 Association of CDKAL1 Polymorphisms with Early-Onset Atopic Dermatitis in Koreans.Ann Dermatol. 2018 Jun;30(3):276-283. doi: 10.5021/ad.2018.30.3.276. Epub 2018 Apr 23.
255 IFN- Reduces Epidermal Barrier Function by Affecting Fatty Acid Composition of Ceramide in a Mouse Atopic Dermatitis Model.J Immunol Res. 2019 Jan 29;2019:3030268. doi: 10.1155/2019/3030268. eCollection 2019.
256 Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis.J Eur Acad Dermatol Venereol. 2017 Jan;31(1):135-141. doi: 10.1111/jdv.13777. Epub 2016 Jun 29.
257 Human S100A15 splice variants are differentially expressed in inflammatory skin diseases and regulated through Th1 cytokines and calcium.Exp Dermatol. 2007 Aug;16(8):685-91. doi: 10.1111/j.1600-0625.2007.00587.x.
258 Chemokine-like factor 1 (CLFK1) is over-expressed in patients with atopic dermatitis.Int J Biol Sci. 2013 Aug 13;9(8):759-65. doi: 10.7150/ijbs.6291. eCollection 2013.
259 Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis.J Invest Dermatol. 2018 Jun;138(6):1279-1287. doi: 10.1016/j.jid.2017.11.040. Epub 2017 Dec 23.
260 A comprehensive analysis of pattern recognition receptors in normal and inflamed human epidermis: upregulation of dectin-1 in psoriasis.J Invest Dermatol. 2010 Nov;130(11):2611-20. doi: 10.1038/jid.2010.196. Epub 2010 Jul 15.
261 Atopic Eczema: Genetic Analysis of COL6A5, COL8A1, and COL10A1 in Mediterranean Populations.Biomed Res Int. 2019 Jun 4;2019:3457898. doi: 10.1155/2019/3457898. eCollection 2019.
262 Identification of novel candidate variants including COL6A6 polymorphisms in early-onset atopic dermatitis using whole-exome sequencing.BMC Med Genet. 2017 Jan 26;18(1):8. doi: 10.1186/s12881-017-0368-9.
263 Investigation of the eotaxin gene -426C-->T, -384A-->G and 67G-->a single-nucleotide polymorphisms and atopic dermatitis in Italian children using family-based association methods.Clin Exp Dermatol. 2008 May;33(3):316-21. doi: 10.1111/j.1365-2230.2007.02672.x. Epub 2008 Feb 28.
264 Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.Int Arch Allergy Immunol. 2017;172(1):11-19. doi: 10.1159/000453452. Epub 2017 Feb 21.
265 A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.Allergy. 2007 May;62(5):514-9. doi: 10.1111/j.1398-9995.2007.01350.x.
266 No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses.Hum Hered. 1998 Sep-Oct;48(5):271-4. doi: 10.1159/000022815.
267 Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo.J Immunol. 2005 Jun 15;174(12):8003-10. doi: 10.4049/jimmunol.174.12.8003.
268 A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.Hum Mol Genet. 2013 Dec 1;22(23):4841-56. doi: 10.1093/hmg/ddt317. Epub 2013 Jul 25.
269 Hint for association of single nucleotide polymorphisms and haplotype in SPINK5 gene with atopic dermatitis in Koreans.Exp Dermatol. 2010 Dec;19(12):1048-53. doi: 10.1111/j.1600-0625.2010.01142.x.
270 Activity, expression and genetic variation of canine -defensin 103: a multifunctional antimicrobial peptide in the skin of domestic dogs.J Innate Immun. 2012;4(3):248-59. doi: 10.1159/000334566. Epub 2012 Jan 19.
271 Topical Application of Josamycin Inhibits Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.J Pharm Pharm Sci. 2017;20:38-47. doi: 10.18433/J3GW3D.
272 Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.J Invest Dermatol. 2020 Apr;140(4):838-849.e9. doi: 10.1016/j.jid.2019.09.011. Epub 2019 Oct 25.
273 Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis.Eur J Dermatol. 2017 Jun 1;27(3):247-253. doi: 10.1684/ejd.2017.2985.
274 Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway.J Cell Biochem. 2009 Oct 15;108(3):705-15. doi: 10.1002/jcb.22307.
275 Staphylococcal enterotoxins modulate the effector CD4(+) T cell response by reshaping the gene expression profile in adults with atopic dermatitis.Sci Rep. 2019 Sep 11;9(1):13082. doi: 10.1038/s41598-019-49421-5.
276 Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin.J Invest Dermatol. 2002 Dec;119(6):1388-93. doi: 10.1046/j.1523-1747.2002.19647.x.
277 Early-onset pediatric atopic dermatitis is characterized by T(H)2/T(H)17/T(H)22-centered inflammation and lipid alterations.J Allergy Clin Immunol. 2018 Jun;141(6):2094-2106. doi: 10.1016/j.jaci.2018.02.040. Epub 2018 May 3.
278 Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.Biochem Biophys Res Commun. 2002 Oct 11;297(5):1282-90. doi: 10.1016/s0006-291x(02)02380-x.
279 Supplemental feeding of phospholipid-enriched alkyl phospholipid from krill relieves spontaneous atopic dermatitis and strengthens skin intercellular lipid barriers in NC/Nga mice.Biosci Biotechnol Biochem. 2019 Apr;83(4):717-727. doi: 10.1080/09168451.2018.1559024. Epub 2018 Dec 20.
280 Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways.BMC Med Genomics. 2015 Oct 12;8:60. doi: 10.1186/s12920-015-0133-x.
281 IL-1 induces thymic stromal lymphopoietin and an atopic dermatitis-like phenotype in reconstructed healthy human epidermis.J Pathol. 2017 Jun;242(2):234-245. doi: 10.1002/path.4887. Epub 2017 Apr 6.
282 Insight into the redox status of inflammatory skin equivalents as determined by EPR spectroscopy.Chem Biol Interact. 2019 Sep 1;310:108752. doi: 10.1016/j.cbi.2019.108752. Epub 2019 Jul 19.
283 The potential role of impaired Notch signalling in atopic dermatitis.Acta Derm Venereol. 2015 Jan;95(1):5-11. doi: 10.2340/00015555-1898.
284 Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions.J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1211-20. doi: 10.1067/mai.2000.107039.
285 Transient epidermal barrier deficiency and lowered allergic threshold in filaggrin-hornerin (FlgHrnr(-/-) ) double-deficient mice.Allergy. 2019 Jul;74(7):1327-1339. doi: 10.1111/all.13756. Epub 2019 Apr 15.
286 Targeted deep sequencing identifies rare loss-of-function variants in IFNGR1 for risk of atopic dermatitis complicated by eczema herpeticum.J Allergy Clin Immunol. 2015 Dec;136(6):1591-1600. doi: 10.1016/j.jaci.2015.06.047. Epub 2015 Sep 3.
287 Differential IL-10 receptor gene expression in acute versus chronic atopic eczema. Modulation by immunosuppressive drugs and cytokines in normal cultured keratinocytes.Inflamm Res. 1999 Oct;48(10):539-43. doi: 10.1007/s000110050500.
288 Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in AtopicDermatitis.J Invest Dermatol. 2020 Mar;140(3):636-644.e2. doi: 10.1016/j.jid.2019.07.713. Epub 2019 Aug 26.
289 IL-9 induces VEGF secretion from human mast cells and IL-9/IL-9 receptor genes are overexpressed in atopic dermatitis.PLoS One. 2012;7(3):e33271. doi: 10.1371/journal.pone.0033271. Epub 2012 Mar 8.
290 Genetic variants in interferon regulatory factor 2 (IRF2) are associated with atopic dermatitis and eczema herpeticum.J Invest Dermatol. 2012 Mar;132(3 Pt 1):650-7. doi: 10.1038/jid.2011.374. Epub 2011 Nov 24.
291 Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis.Mucosal Immunol. 2017 Nov;10(6):1491-1503. doi: 10.1038/mi.2017.10. Epub 2017 Feb 22.
292 Atopic Dermatitis-like Graft-versus-host Disease and Lichen Planus-like Graft-versus-host Disease: Alterations in Skin Barrier Function and Related Molecules.Chin Med J (Engl). 2017 Jun 20;130(12):1459-1466. doi: 10.4103/0366-6999.207475.
293 Early cutaneous gene transcription changes in adult atopic dermatitis and potential clinical implications.Exp Dermatol. 2007 Jan;16(1):28-36. doi: 10.1111/j.1600-0625.2006.00504.x.
294 Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis.Pediatr Allergy Immunol. 2006 Dec;17(8):578-82. doi: 10.1111/j.1399-3038.2006.00468.x.
295 Osthole attenuates mouse atopic dermatitis by inhibiting thymic stromal lymphopoietin production from keratinocytes.Exp Dermatol. 2019 May;28(5):561-567. doi: 10.1111/exd.13910.
296 Keratinocyte Proline-Rich Protein DeficiencyinAtopic Dermatitis Leads to Barrier Disruption.J Invest Dermatol. 2019 Sep;139(9):1867-1875.e7. doi: 10.1016/j.jid.2019.02.030. Epub 2019 Mar 21.
297 Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro.Cell Tissue Res. 2015 Sep;361(3):789-97. doi: 10.1007/s00441-015-2162-3. Epub 2015 Mar 18.
298 IL-33-Induced Atopic Dermatitis-Like Inflammation in Mice Is Mediated by Group 2 Innate Lymphoid Cells in Concert with Basophils.J Invest Dermatol. 2019 Oct;139(10):2185-2194.e3. doi: 10.1016/j.jid.2019.04.016. Epub 2019 May 21.
299 An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease.J Invest Dermatol. 2017 Mar;137(3):603-613. doi: 10.1016/j.jid.2016.09.037. Epub 2016 Nov 4.
300 The effects of season and weather on healthcare utilization among patients with atopic dermatitis.J Eur Acad Dermatol Venereol. 2018 Oct;32(10):1745-1753. doi: 10.1111/jdv.15023. Epub 2018 May 31.
301 Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes.J Invest Dermatol. 2015 Jan;135(1):142-150. doi: 10.1038/jid.2014.330. Epub 2014 Aug 4.
302 Identification of candidate genes in atopic dermatitis based on bioinformatic methods.Int J Dermatol. 2016 Jul;55(7):791-800. doi: 10.1111/ijd.13291. Epub 2016 Mar 9.
303 Investigation of the chromosome 17q25 PSORS2 locus in atopic dermatitis.J Invest Dermatol. 2006 Mar;126(3):603-6. doi: 10.1038/sj.jid.5700108.
304 Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease.J Biol Chem. 2004 Dec 31;279(53):55493-8. doi: 10.1074/jbc.M409770200. Epub 2004 Oct 18.
305 Linkage and association to candidate regions in Swedish atopic dermatitis families.Hum Genet. 2001 Aug;109(2):129-35. doi: 10.1007/s004390100556.
306 Is there an association between indoor allergens and the severity of atopic dermatitis?.Int J Dermatol. 2019 Apr;58(4):433-439. doi: 10.1111/ijd.14281. Epub 2018 Nov 23.
307 Neuroplastin- mediates S100A8/A9-induced lung cancer disseminative progression.Mol Carcinog. 2019 Jun;58(6):980-995. doi: 10.1002/mc.22987. Epub 2019 Feb 27.
308 Specificity protein 1 is pivotal in the skin's antiviral response.J Allergy Clin Immunol. 2011 Feb;127(2):430-438.e1-2. doi: 10.1016/j.jaci.2010.11.013. Epub 2011 Jan 5.
309 Amphiphilic Triazine Polymer Derivatives as Antibacterial And Anti-atopic Agents in Mice Model.Sci Rep. 2019 Oct 22;9(1):15161. doi: 10.1038/s41598-019-51561-7.
310 The PCDH1 gene and asthma in early childhood.Eur Respir J. 2014 Mar;43(3):792-800. doi: 10.1183/09031936.00021613. Epub 2013 Aug 29.
311 Hypoxia inhibits TNF--induced TSLP expression in keratinocytes.PLoS One. 2019 Nov 4;14(11):e0224705. doi: 10.1371/journal.pone.0224705. eCollection 2019.
312 Functional characterization of the atopy-associated gene PHF11.J Allergy Clin Immunol. 2008 May;121(5):1148-1154.e3. doi: 10.1016/j.jaci.2008.02.028. Epub 2008 Apr 11.
313 The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease.J Am Acad Dermatol. 2019 Aug;81(2):510-519. doi: 10.1016/j.jaad.2019.04.036. Epub 2019 Apr 19.
314 Phosphodiesterase 4D, miR-203 and selected cytokines in the peripheral blood are associated with canine atopic dermatitis.PLoS One. 2019 Jun 21;14(6):e0218670. doi: 10.1371/journal.pone.0218670. eCollection 2019.
315 Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs.BMC Genet. 2016 Jun 29;17(1):97. doi: 10.1186/s12863-016-0404-3.
316 Cloning of a gene for a novel epithelium-specific cytosolic phospholipase A2, cPLA2delta, induced in psoriatic skin.J Biol Chem. 2004 Mar 26;279(13):12890-7. doi: 10.1074/jbc.M305801200. Epub 2004 Jan 6.
317 Critical role for mast cell Stat5 activity in skin inflammation.Cell Rep. 2014 Jan 30;6(2):366-76. doi: 10.1016/j.celrep.2013.12.029. Epub 2014 Jan 9.
318 Increasing severity of atopic dermatitis is associated with a negative impact on work productivity among adults with atopic dermatitis in France, Germany, the U.K. and the U.S.A.Br J Dermatol. 2020 Apr;182(4):1007-1016. doi: 10.1111/bjd.18296. Epub 2019 Sep 8.
319 CD100-Plexin-B2 Promotes the Inflammation in Psoriasis by Activating NF-B and the Inflammasome inKeratinocytes.J Invest Dermatol. 2018 Feb;138(2):375-383. doi: 10.1016/j.jid.2017.09.005. Epub 2017 Sep 18.
320 Elevated platelet activation in patients with atopic dermatitis and psoriasis: increased plasma levels of beta-thromboglobulin and platelet factor 4.Allergol Int. 2008 Dec;57(4):391-6. doi: 10.2332/allergolint.O-08-537. Epub 2008 Dec 1.
321 Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.Nat Genet. 2011 Jun 12;43(7):690-4. doi: 10.1038/ng.851.
322 Association of Single-Nucleotide Polymorphisms of the MBL2 with Atopic Dermatitis in Korean Patients.Ann Dermatol. 2017 Oct;29(5):571-577. doi: 10.5021/ad.2017.29.5.571. Epub 2017 Aug 25.
323 The effect of autophagy-enhancing peptide in moisturizer on atopic dermatitis: a randomized controlled trial.J Dermatolog Treat. 2019 Sep;30(6):558-564. doi: 10.1080/09546634.2018.1544407. Epub 2018 Dec 2.
324 Association analyses identify two susceptibility loci 5q31 and 5q22.1 for atopic dermatitis in Chinese Han population.Asian Pac J Allergy Immunol. 2017 Dec;35(4):196-202. doi: 10.12932/AP0869.
325 Mice lacking the transcription factor RelB develop T cell-dependent skin lesions similar to human atopic dermatitis.Eur J Immunol. 2000 Aug;30(8):2323-32. doi: 10.1002/1521-4141(2000)30:8<2323::AID-IMMU2323>3.0.CO;2-H.
326 Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome.Clin Exp Immunol. 2005 Jun;140(3):524-31. doi: 10.1111/j.1365-2249.2005.02805.x.
327 Unique profile of antimicrobial peptide expression in polymorphic light eruption lesions compared to healthy skin, atopic dermatitis, and psoriasis.Photodermatol Photoimmunol Photomed. 2018 Mar;34(2):137-144. doi: 10.1111/phpp.12355. Epub 2017 Nov 13.
328 A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.J Allergy Clin Immunol. 2015 Sep;136(3):802-6. doi: 10.1016/j.jaci.2015.01.047. Epub 2015 Apr 10.
329 Burden of Atopic Dermatitis in the United States: Analysis of Healthcare Claims Data in the Commercial, Medicare, and Medi-Cal Databases.Adv Ther. 2017 Aug;34(8):1989-2006. doi: 10.1007/s12325-017-0582-z. Epub 2017 Jul 13.
330 Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis.PLoS One. 2017 Jul 14;12(7):e0181486. doi: 10.1371/journal.pone.0181486. eCollection 2017.
331 Decreased expression of suprabasin induces aberrant differentiation and apoptosis of epidermal keratinocytes: Possible role for atopic dermatitis.J Dermatol Sci. 2019 Sep;95(3):107-112. doi: 10.1016/j.jdermsci.2019.07.009. Epub 2019 Jul 27.
332 An inhibitory role for Sema4A in antigen-specific allergic asthma.J Clin Immunol. 2013 Jan;33(1):200-9. doi: 10.1007/s10875-012-9798-5. Epub 2012 Sep 25.
333 Serum squamous cell carcinoma antigen (SCCA)-2 correlates with clinical severity of pediatric atopic dermatitis in Ishigaki cohort.J Dermatol Sci. 2019 Aug;95(2):70-75. doi: 10.1016/j.jdermsci.2019.07.005. Epub 2019 Jul 24.
334 The role of Staphylococcus aureus in atopic dermatitis: microbiological and immunological implications.Postepy Dermatol Alergol. 2019 Aug;36(4):485-491. doi: 10.5114/ada.2018.77056. Epub 2019 Aug 30.
335 Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers.PLoS One. 2018 Apr 26;13(4):e0196595. doi: 10.1371/journal.pone.0196595. eCollection 2018.
336 Irradiation with 310 nm and 340 nm ultraviolet light-emitting-diodes can improve atopic dermatitis-like skin lesions in NC/Nga mice.Photochem Photobiol Sci. 2018 Aug 8;17(8):1127-1135. doi: 10.1039/c8pp00063h.
337 Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis.Clin Exp Immunol. 2004 Mar;135(3):505-10. doi: 10.1111/j.1365-2249.2004.02405.x.
338 The history of atopic dermatitis.Clin Dermatol. 2017 Jul-Aug;35(4):344-348. doi: 10.1016/j.clindermatol.2017.03.005. Epub 2017 Mar 23.
339 Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases.J Biol Chem. 2010 Oct 15;285(42):32174-81. doi: 10.1074/jbc.M109.091850. Epub 2010 Jul 28.
340 Skin neurogenic inflammation.Semin Immunopathol. 2018 May;40(3):249-259. doi: 10.1007/s00281-018-0675-z. Epub 2018 Apr 30.
341 Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.FEBS Lett. 2004 Aug 13;572(1-3):135-40. doi: 10.1016/j.febslet.2004.07.023.
342 Genome-wide analysis in German shepherd dogs reveals association of a locus on CFA 27 with atopic dermatitis.PLoS Genet. 2013 May;9(5):e1003475. doi: 10.1371/journal.pgen.1003475. Epub 2013 May 9.
343 Interferon- decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis.J Invest Dermatol. 2014 Mar;134(3):712-718. doi: 10.1038/jid.2013.364. Epub 2013 Sep 5.
344 Atopic Eczema: Genetic Associations and Potential Links to Developmental Exposures.Int J Toxicol. 2017 May/Jun;36(3):187-198. doi: 10.1177/1091581817701075. Epub 2017 Mar 30.
345 Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion.J Clin Invest. 2006 Oct;116(10):2748-56. doi: 10.1172/JCI24274. Epub 2006 Sep 7.
346 TOX expression in different subtypes of cutaneous lymphoma.Arch Dermatol Res. 2014 Nov;306(9):843-9. doi: 10.1007/s00403-014-1501-7. Epub 2014 Sep 13.
347 An atopic dermatitis-like skin disease with hyper-IgE-emia develops in mice carrying a spontaneous recessive point mutation in the Traf3ip2 (Act1/CIKS) gene.J Immunol. 2010 Aug 15;185(4):2340-9. doi: 10.4049/jimmunol.0900694. Epub 2010 Jul 21.
348 Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis.J Invest Dermatol. 2017 Feb;137(2):359-366. doi: 10.1016/j.jid.2016.09.020. Epub 2016 Oct 5.
349 CXCL17 Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation by Recruiting Myeloid-Derived Suppressor Cells and Regulatory T Cells.J Immunol. 2017 May 15;198(10):3897-3908. doi: 10.4049/jimmunol.1601607. Epub 2017 Apr 7.
350 IL-17C amplifies epithelial inflammation in human psoriasis and atopic eczema.J Eur Acad Dermatol Venereol. 2020 Apr;34(4):800-809. doi: 10.1111/jdv.16126. Epub 2020 Jan 19.
351 Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).Biochem Biophys Res Commun. 2002 Apr 5;292(3):689-96. doi: 10.1006/bbrc.2002.6716.