Details of the Drug

General Information of Drug (ID: DMNZA4L)

Drug Name

Griffithsin

Synonyms

GRFT

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Phase 1	[1]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[2]
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Therapeutic Class

Antiviral Agents

Drug Type

Protein/peptide drug

Sequence

SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDAIIIDGVHHGGSGGNLSPTFTFGSGEYISN
MTIRSGDYINISFETNMGRRFGPTYGGSGGSANTLSNVKVIQINGSAGDYLDSLDIYYEQ
Y

Cross-matching ID

Repurposed Drugs (RPD)

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SARS-CoV spike glycoprotein (S)	TTTL19V	SPIKE_CVHSA	Blocker	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	ClinicalTrials.gov (NCT02875119) Study to Evaluate the Safety of Griffithsin in a Carrageenan Gel in Healthy Women
2	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.